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Ravindra Uppaluri, M.D.

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Biography
University of Minnesota, MinneapolisPhD1995Genetics
University of Minnesota, MinneapolisMD1995Medicine

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U01DE029188 (UPPALURI, RAVINDRA) Sep 24, 2019 - Aug 31, 2024
    NIH
    Defining mechanisms of immunotherapy resistance in head and neck squamous cell carcinomas
    Role: Principal Investigator
  2. R01DE027736 (UPPALURI, RAVINDRA) Apr 11, 2018 - Mar 31, 2023
    NIH
    Immunotherapeutic responses to neoantigens in head and neck cancer
    Role: Principal Investigator
  3. R01DE024403 (UPPALURI, RAVINDRA) Jul 20, 2014 - Jun 30, 2020
    NIH
    GENOMIC INSIGHTS AND THERAPEUTIC TARGETING OF ORAL CANCER TUMOR INITIATING CELLS
    Role: Principal Investigator
  4. K08CA090403 (UPPALURI, RAVINDRA) Feb 14, 2002 - Jan 31, 2008
    NIH
    IFN Gamma Induced Angiostatic Chemokines
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Arbab M, Chen YH, Tishler RB, Gunasti L, Glass J, Fugazzotto JA, Killoran JH, Sethi R, Rettig E, Annino D, Goguen L, Uppaluri R, Hsu C, Burke E, Hanna GJ, Lorch J, Haddad RI, Margalit DN, Schoenfeld JD. Association between radiation dose to organs at risk and acute patient reported outcome during radiation treatment for head and neck cancers. Head Neck. 2022 Mar 31. PMID: 35355358.
    Citations:    Fields:    
  2. Rettig EM, Faden DL, Sandhu S, Wong K, Faquin WC, Warinner C, Stephens P, Kumar S, Kuperwasser C, Richmon JD, Uppaluri R, Varvares M, Sethi R, Hanna GJ, Sroussi H. Detection of circulating tumor human papillomavirus DNA before diagnosis of HPV-positive head and neck cancer. Int J Cancer. 2022 Mar 09. PMID: 35262203.
    Citations:    Fields:    
  3. Obradovic A, Graves D, Korrer M, Wang Y, Roy S, Naveed A, Xu Y, Luginbuhl A, Curry J, Gibson M, Idrees K, Hurley P, Jiang P, Liu XS, Uppaluri R, Drake CG, Califano A, Kim YJ. Immunostimulatory cancer-associated fibroblast subpopulations can predict immunotherapy response in head and neck cancer. Clin Cancer Res. 2022 Mar 09. PMID: 35262677.
    Citations:    Fields:    
  4. Egloff AM, Uppaluri R. Preoperative immunotherapy for head and neck cancers: state of art. Curr Opin Oncol. 2022 Mar 07. PMID: 35256551.
    Citations:    Fields:    
  5. Shah H, Wang Y, Cheng SC, Gunasti L, Chen YH, Lako A, Guenette J, Rodig S, Jo VY, Uppaluri R, Haddad R, Schoenfeld JD, Jacene HA. Use of Fluoro-[18F]-Deoxy-2-D-Glucose Positron Emission Tomography/Computed Tomography to Predict Immunotherapy Treatment Response in Patients With Squamous Cell Oral Cavity Cancers. JAMA Otolaryngol Head Neck Surg. 2022 Mar 01; 148(3):268-276. PMID: 35050348.
    Citations:    Fields:    
  6. Zeng Z, Wong CJ, Yang L, Ouardaoui N, Li D, Zhang W, Gu S, Zhang Y, Liu Y, Wang X, Fu J, Zhou L, Zhang B, Kim S, Yates KB, Brown M, Freeman GJ, Uppaluri R, Manguso R, Liu XS. TISMO: syngeneic mouse tumor database to model tumor immunity and immunotherapy response. Nucleic Acids Res. 2022 01 07; 50(D1):D1391-D1397. PMID: 34534350.
    Citations: 1     Fields:    Translation:HumansAnimals
  7. Zhou L, Zeng Z, Egloff AM, Zhang F, Guo F, Campbell KM, Du P, Fu J, Zolkind P, Ma X, Zhang Z, Zhang Y, Wang X, Gu S, Riley R, Nakahori Y, Keegan J, Haddad R, Schoenfeld JD, Griffith O, Manguso RT, Lederer JA, Liu XS, Uppaluri R. Checkpoint blockade-induced CD8+ T cell differentiation in head and neck cancer responders. J Immunother Cancer. 2022 01; 10(1). PMID: 35058328.
    Citations:    Fields:    
  8. Mishra S, Suh CH, Bergmark RW, Jo VY, Miyawaki EK, Schoenfeld JD, Uppaluri R, Guenette JP. Imaging features, therapies, and outcomes of fibrosing inflammatory pseudotumor of the nasopharynx: A systematic review. J Neuroimaging. 2022 Mar; 32(2):223-229. PMID: 34879175.
    Citations:    Fields:    
  9. Hanna GJ, O'Neill A, Shin KY, Wong K, Jo VY, Quinn CT, Cutler JM, Flynn M, Lizotte PH, Annino DJ, Goguen LA, Kass JI, Rettig EM, Sethi RKV, Lorch JH, Schoenfeld JD, Margalit DN, Tishler RB, Everett PC, Desai AM, Cavanaugh ME, Paweletz CP, Egloff AM, Uppaluri R, Haddad RI. Neoadjuvant and Adjuvant Nivolumab and Lirilumab in Patients with Recurrent, Resectable Squamous Cell Carcinoma of the Head and Neck. Clin Cancer Res. 2022 02 01; 28(3):468-478. PMID: 34667025.
    Citations: 1     Fields:    Translation:CTClinical Trials
  10. Shibata H, Saito S, Uppaluri R. Immunotherapy for Head and Neck Cancer: A Paradigm Shift From Induction Chemotherapy to Neoadjuvant Immunotherapy. Front Oncol. 2021; 11:727433. PMID: 34552878.
    Citations:    
  11. Shibata H, Xu N, Saito S, Zhou L, Ozgenc I, Webb J, Fu C, Zolkind P, Egloff AM, Uppaluri R. Integrating CD4+ T cell help for therapeutic cancer vaccination in a preclinical head and neck cancer model. Oncoimmunology. 2021; 10(1):1958589. PMID: 34408919.
    Citations: 1     Fields:    Translation:AnimalsCellsPHPublic Health
  12. Miller AL, Holcomb AJ, Parikh AS, Richards JM, Rathi VK, Goldfarb JW, Remenschneider AK, Bergmark RW, Annino DJ, Goguen LA, Rettig EM, Deschler DG, Emerick KS, Lin DT, Richmon JD, Chan CL, Min LC, Uppaluri R, Varvares MA. Assessment of Preoperative Functional Status Prior to Major Head and Neck Surgery: A Pilot Study. Otolaryngol Head Neck Surg. 2022 Apr; 166(4):688-695. PMID: 34154446.
    Citations:    Fields:    
  13. Bauman JE, Harris J, Uppaluri R, Yao M, Ferris RL, Chen J, Jordan RC, Joshi NP, Jujjuvaparu S, Blakaj DM, Henson C, Sheqwara J, Mell LK, Sen N, Clump DA, Garg MK, Yilmaz E, Torres-Saavedra P, Le QT. NRG-HN003: Phase I and Expansion Cohort Study of Adjuvant Pembrolizumab, Cisplatin and Radiation Therapy in Pathologically High-Risk Head and Neck Cancer. Cancers (Basel). 2021 Jun 09; 13(12). PMID: 34207599.
    Citations:    
  14. Lonardi S, Missale F, Calza S, Bugatti M, Vescovi R, Debora B, Uppaluri R, Egloff AM, Mattavelli D, Lombardi D, Benerini Gatta L, Marini O, Tamassia N, Gardiman E, Cassatella MA, Scapini P, Nicolai P, Vermi W. Tumor-associated neutrophils (TANs) in human carcinoma-draining lymph nodes: a novel TAN compartment. Clin Transl Immunology. 2021; 10(2):e1252. PMID: 33643653.
    Citations: 3     
  15. Mudianto T, Campbell KM, Webb J, Zolkind P, Skidmore ZL, Riley R, Barnell EK, Ozgenc I, Giri T, Dunn GP, Adkins DR, Griffith M, Egloff AM, Griffith OL, Uppaluri R. Yap1 Mediates Trametinib Resistance in Head and Neck Squamous Cell Carcinomas. Clin Cancer Res. 2021 04 15; 27(8):2326-2339. PMID: 33547198.
    Citations: 1     Fields:    Translation:CTClinical Trials
  16. Schoenfeld JD, Uppaluri R, Haddad RI. Clinical Decision-making About Neoadjuvant Nivolumab Plus Ipilimumab-Reply. JAMA Oncol. 2021 02 01; 7(2):309-310. PMID: 33355594.
    Citations:    Fields:    Translation:Humans
  17. Shibata H, Zhou L, Xu N, Egloff AM, Uppaluri R. Personalized cancer vaccination in head and neck cancer. Cancer Sci. 2021 Mar; 112(3):978-988. PMID: 33368875.
    Citations: 3     Fields:    Translation:Humans
  18. Zhou L, Xu N, Shibata H, Saloura V, Uppaluri R. Epigenetic modulation of immunotherapy and implications in head and neck cancer. Cancer Metastasis Rev. 2021 03; 40(1):141-152. PMID: 33403469.
    Citations: 7     Fields:    Translation:Humans
  19. Uppaluri R, Campbell KM, Egloff AM, Zolkind P, Skidmore ZL, Nussenbaum B, Paniello RC, Rich JT, Jackson R, Pipkorn P, Michel LS, Ley J, Oppelt P, Dunn GP, Barnell EK, Spies NC, Lin T, Li T, Mulder DT, Hanna Y, Cirlan I, Pugh TJ, Mudianto T, Riley R, Zhou L, Jo VY, Stachler MD, Hanna GJ, Kass J, Haddad R, Schoenfeld JD, Gjini E, Lako A, Thorstad W, Gay HA, Daly M, Rodig SJ, Hagemann IS, Kallogjeri D, Piccirillo JF, Chernock RD, Griffith M, Griffith OL, Adkins DR. Correction: Neoadjuvant and Adjuvant Pembrolizumab in Resectable Locally Advanced, Human Papillomavirus-unrelated Head and Neck Cancer: A Multicenter, Phase II Trial. Clin Cancer Res. 2021 Jan 01; 27(1):357. PMID: 33397681.
    Citations: 1     Fields:    
  20. Hanna GJ, Rettig EM, Park JC, Varvares MA, Lorch JH, Margalit DN, Schoenfeld JD, Tishler RB, Goguen LA, Annino DJ, Haddad RI, Uppaluri R. Hospitalization rates and 30-day all-cause mortality among head and neck cancer patients and survivors with COVID-19. Oral Oncol. 2021 01; 112:105087. PMID: 33190021.
    Citations: 1     Fields:    Translation:HumansCells
  21. Schoenfeld JD, Hanna GJ, Jo VY, Rawal B, Chen YH, Catalano PS, Lako A, Ciantra Z, Weirather JL, Criscitiello S, Luoma A, Chau N, Lorch J, Kass JI, Annino D, Goguen L, Desai A, Ross B, Shah HJ, Jacene HA, Margalit DN, Tishler RB, Wucherpfennig KW, Rodig SJ, Uppaluri R, Haddad RI. Neoadjuvant Nivolumab or Nivolumab Plus Ipilimumab in Untreated Oral Cavity Squamous Cell Carcinoma: A Phase 2 Open-Label Randomized Clinical Trial. JAMA Oncol. 2020 10 01; 6(10):1563-1570. PMID: 32852531.
    Citations: 32     Fields:    Translation:HumansCTClinical Trials
  22. Uppaluri R, Campbell KM, Egloff AM, Zolkind P, Skidmore ZL, Nussenbaum B, Paniello RC, Rich JT, Jackson R, Pipkorn P, Michel LS, Ley J, Oppelt P, Dunn GP, Barnell EK, Spies NC, Lin T, Li T, Mulder DT, Hanna Y, Cirlan I, Pugh TJ, Mudianto T, Riley R, Zhou L, Jo VY, Stachler MD, Hanna GJ, Kass J, Haddad R, Schoenfeld JD, Gjini E, Lako A, Thorstad W, Gay HA, Daly M, Rodig SJ, Hagemann IS, Kallogjeri D, Piccirillo JF, Chernock RD, Griffith M, Griffith OL, Adkins DR. Neoadjuvant and Adjuvant Pembrolizumab in Resectable Locally Advanced, Human Papillomavirus-Unrelated Head and Neck Cancer: A Multicenter, Phase II Trial. Clin Cancer Res. 2020 10 01; 26(19):5140-5152. PMID: 32665297.
    Citations: 34     Fields:    Translation:HumansCellsCTClinical Trials
  23. Mehanna H, Hardman JC, Shenson JA, Abou-Foul AK, Topf MC, AlFalasi M, Chan JYK, Chaturvedi P, Chow VLY, Dietz A, Fagan JJ, Godballe C, Golusinski W, Homma A, Hosal S, Iyer NG, Kerawala C, Koh YW, Konney A, Kowalski LP, Kraus D, Kuriakose MA, Kyrodimos E, Lai SY, Leemans CR, Lennon P, Licitra L, Lou PJ, Lyons B, Mirghani H, Nichols AC, Paleri V, Panizza BJ, Parente Arias P, Patel MR, Piazza C, Rischin D, Sanabria A, Takes RP, Thomson DJ, Uppaluri R, Wang Y, Yom SS, Zhu YM, Porceddu SV, de Almeida JR, Simon C, Holsinger FC. Recommendations for head and neck surgical oncology practice in a setting of acute severe resource constraint during the COVID-19 pandemic: an international consensus. Lancet Oncol. 2020 07; 21(7):e350-e359. PMID: 32534633.
    Citations: 31     Fields:    Translation:HumansCellsPHPublic Health
  24. Fu Y, Liu CJ, Kobayashi DK, Johanns TM, Bowman-Kirigin JA, Schaettler MO, Mao DD, Bender D, Kelley DG, Uppaluri R, Bi WL, Dunn IF, Tao Y, Luo J, Kim AH, Dunn GP. GATA2 Regulates Constitutive PD-L1 and PD-L2 Expression in Brain Tumors. Sci Rep. 2020 06 03; 10(1):9027. PMID: 32493985.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  25. Caulley L, Uppaluri R, Dunn IF. Perioperative nasal and paranasal sinus considerations in transsphenoidal surgery for pituitary disease. Br J Neurosurg. 2020 Jun; 34(3):246-252. PMID: 32098510.
    Citations: 1     Fields:    Translation:Humans
  26. Nambiar DK, Aguilera T, Cao H, Kwok S, Kong C, Bloomstein J, Wang Z, Rangan VS, Jiang D, von Eyben R, Liang R, Agarwal S, Colevas AD, Korman A, Allen CT, Uppaluri R, Koong AC, Giaccia A, Le QT. Galectin-1-driven T cell exclusion in the tumor endothelium promotes immunotherapy resistance. J Clin Invest. 2019 12 02; 129(12):5553-5567. PMID: 31710313.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  27. Friedman J, Moore EC, Zolkind P, Robbins Y, Clavijo PE, Sun L, Greene S, Morisada MV, Mydlarz WK, Schmitt N, Hodge JW, Schreiber H, Van Waes C, Uppaluri R, Allen C. Neoadjuvant PD-1 Immune Checkpoint Blockade Reverses Functional Immunodominance among Tumor Antigen-Specific T Cells. Clin Cancer Res. 2020 02 01; 26(3):679-689. PMID: 31645352.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  28. Barnell EK, Waalkes A, Mosior MC, Penewit K, Cotto KC, Danos AM, Sheta LM, Campbell KM, Krysiak K, Rieke D, Spies NC, Skidmore ZL, Pritchard CC, Fehniger TA, Uppaluri R, Govindan R, Griffith M, Salipante SJ, Griffith OL. Open-Sourced CIViC Annotation Pipeline to Identify and Annotate Clinically Relevant Variants Using Single-Molecule Molecular Inversion Probes. JCO Clin Cancer Inform. 2019 10; 3:1-12. PMID: 31618044.
    Citations: 1     Fields:    Translation:Humans
  29. Zhou L, Mudianto T, Ma X, Riley R, Uppaluri R. Targeting EZH2 Enhances Antigen Presentation, Antitumor Immunity, and Circumvents Anti-PD-1 Resistance in Head and Neck Cancer. Clin Cancer Res. 2020 01 01; 26(1):290-300. PMID: 31562203.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  30. Gupta A, Sonis S, Uppaluri R, Bergmark RW, Villa A. Disparities in Oral Cancer Screening Among Dental Professionals: NHANES 2011-2016. Am J Prev Med. 2019 10; 57(4):447-457. PMID: 31443957.
    Citations: 4     Fields:    Translation:Humans
  31. Cohen EEW, Bell RB, Bifulco CB, Burtness B, Gillison ML, Harrington KJ, Le QT, Lee NY, Leidner R, Lewis RL, Licitra L, Mehanna H, Mell LK, Raben A, Sikora AG, Uppaluri R, Whitworth F, Zandberg DP, Ferris RL. The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC). J Immunother Cancer. 2019 07 15; 7(1):184. PMID: 31307547.
    Citations: 133     Fields:    Translation:HumansCTClinical Trials
  32. Hundal J, Kiwala S, Feng YY, Liu CJ, Govindan R, Chapman WC, Uppaluri R, Swamidass SJ, Griffith OL, Mardis ER, Griffith M. Accounting for proximal variants improves neoantigen prediction. Nat Genet. 2019 01; 51(1):175-179. PMID: 30510237.
    Citations: 16     Fields:    Translation:Humans
  33. Ainscough BJ, Barnell EK, Ronning P, Campbell KM, Wagner AH, Fehniger TA, Dunn GP, Uppaluri R, Govindan R, Rohan TE, Griffith M, Mardis ER, Swamidass SJ, Griffith OL. A deep learning approach to automate refinement of somatic variant calling from cancer sequencing data. Nat Genet. 2018 12; 50(12):1735-1743. PMID: 30397337.
    Citations: 16     Fields:    Translation:Humans
  34. Hanna GJ, Kacew A, Chau NG, Shivdasani P, Lorch JH, Uppaluri R, Haddad RI, MacConaill LE. Improved outcomes in PI3K-pathway-altered metastatic HPV oropharyngeal cancer. JCI Insight. 2018 09 06; 3(17). PMID: 30185662.
    Citations: 7     Fields:    Translation:HumansCells
  35. Campbell KM, Lin T, Zolkind P, Barnell EK, Skidmore ZL, Winkler AE, Law JH, Mardis ER, Wartman LD, Adkins DR, Chernock RD, Griffith M, Uppaluri R, Griffith OL. Oral Cavity Squamous Cell Carcinoma Xenografts Retain Complex Genotypes and Intertumor Molecular Heterogeneity. Cell Rep. 2018 08 21; 24(8):2167-2178. PMID: 30134176.
    Citations: 9     Fields:    Translation:HumansAnimals
  36. Sridharan V, Rahman RM, Huang RY, Chau NG, Lorch JH, Uppaluri R, Haddad RI, Hanna GJ, Schoenfeld JD. Radiologic predictors of immune checkpoint inhibitor response in advanced head and neck squamous cell carcinoma. Oral Oncol. 2018 10; 85:29-34. PMID: 30220316.
    Citations: 5     Fields:    Translation:Humans
  37. Cañadas I, Thummalapalli R, Kim JW, Kitajima S, Jenkins RW, Christensen CL, Campisi M, Kuang Y, Zhang Y, Gjini E, Zhang G, Tian T, Sen DR, Miao D, Imamura Y, Thai T, Piel B, Terai H, Aref AR, Hagan T, Koyama S, Watanabe M, Baba H, Adeni AE, Lydon CA, Tamayo P, Wei Z, Herlyn M, Barbie TU, Uppaluri R, Sholl LM, Sicinska E, Sands J, Rodig S, Wong KK, Paweletz CP, Watanabe H, Barbie DA. Tumor innate immunity primed by specific interferon-stimulated endogenous retroviruses. Nat Med. 2018 08; 24(8):1143-1150. PMID: 30038220.
    Citations: 94     Fields:    Translation:HumansAnimalsCells
  38. Schoenfeld JD, Gjini E, Rodig SJ, Tishler RB, Rawal B, Catalano PJ, Uppaluri R, Haddad RI, Hanna GJ, Chau NG, Rabinowits G, Lorch J, Jo VY, Krane JF, Goguen LA, Annino DJ, Abdelrahman S, Lipschitz M, Margalit DN. Evaluating the PD-1 Axis and Immune Effector Cell Infiltration in Oropharyngeal Squamous Cell Carcinoma. Int J Radiat Oncol Biol Phys. 2018 09 01; 102(1):137-145. PMID: 29960819.
    Citations: 9     Fields:    Translation:HumansCells
  39. Hanna GJ, Kofman ER, Shazib MA, Woo SB, Reardon B, Treister NS, Haddad RI, Cutler CS, Antin JH, Van Allen EM, Uppaluri R, Soiffer RJ. Integrated genomic characterization of oral carcinomas in post-hematopoietic stem cell transplantation survivors. Oral Oncol. 2018 06; 81:1-9. PMID: 29884406.
    Citations: 3     Fields:    Translation:Humans
  40. Hanna GJ, Lizotte P, Cavanaugh M, Kuo FC, Shivdasani P, Frieden A, Chau NG, Schoenfeld JD, Lorch JH, Uppaluri R, MacConaill LE, Haddad RI. Frameshift events predict anti-PD-1/L1 response in head and neck cancer. JCI Insight. 2018 02 22; 3(4). PMID: 29467336.
    Citations: 70     Fields:    Translation:Humans
  41. Redlich N, Robinson AM, Nickel KP, Stein AP, Wheeler DL, Adkins DR, Uppaluri R, Kimple RJ, Van Tine BA, Michel LS. Anti-Trop2 blockade enhances the therapeutic efficacy of ErbB3 inhibition in head and neck squamous cell carcinoma. Cell Death Dis. 2018 01 05; 9(1):5. PMID: 29305574.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  42. Zolkind P, Przybylski D, Marjanovic N, Nguyen L, Lin T, Johanns T, Alexandrov A, Zhou L, Allen CT, Miceli AP, Schreiber RD, Artyomov M, Dunn GP, Uppaluri R. Cancer immunogenomic approach to neoantigen discovery in a checkpoint blockade responsive murine model of oral cavity squamous cell carcinoma. Oncotarget. 2018 Jan 09; 9(3):4109-4119. PMID: 29423108.
    Citations: 16     Fields:    
  43. Chung MK, Jung YH, Lee JK, Cho SY, Murillo-Sauca O, Uppaluri R, Shin JH, Sunwoo JB. CD271 Confers an Invasive and Metastatic Phenotype of Head and Neck Squamous Cell Carcinoma through the Upregulation of Slug. Clin Cancer Res. 2018 02 01; 24(3):674-683. PMID: 29208672.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  44. Zolkind P, Uppaluri R. Checkpoint immunotherapy in head and neck cancers. Cancer Metastasis Rev. 2017 09; 36(3):475-489. PMID: 28836124.
    Citations: 15     Fields:    Translation:HumansAnimals
  45. Hanna GJ, Adkins DR, Zolkind P, Uppaluri R. Rationale for neoadjuvant immunotherapy in head and neck squamous cell carcinoma. Oral Oncol. 2017 10; 73:65-69. PMID: 28939078.
    Citations: 16     Fields:    Translation:Humans
  46. Graboyes EM, Aranake-Chrisinger J, Uppaluri R. Retropharyngeal Mass. JAMA Otolaryngol Head Neck Surg. 2017 04 01; 143(4):421-422. PMID: 27978561.
    Citations: 1     Fields:    Translation:Humans
  47. Hanna GJ, Liu H, Jones RE, Bacay AF, Lizotte PH, Ivanova EV, Bittinger MA, Cavanaugh ME, Rode AJ, Schoenfeld JD, Chau NG, Haddad RI, Lorch JH, Wong KK, Uppaluri R, Hammerman PS. Defining an inflamed tumor immunophenotype in recurrent, metastatic squamous cell carcinoma of the head and neck. Oral Oncol. 2017 04; 67:61-69. PMID: 28351582.
    Citations: 25     Fields:    Translation:Humans
  48. Uppaluri R, Winkler AE, Lin T, Law JH, Haughey BH, Nussenbaum B, Paniello RC, Rich JT, Diaz JA, Michel LP, Wildes T, Dunn GP, Zolkind P, Kallogjeri D, Piccirillo JF, Dehdashti F, Siegel BA, Chernock RD, Lewis JS, Adkins DR. Biomarker and Tumor Responses of Oral Cavity Squamous Cell Carcinoma to Trametinib: A Phase II Neoadjuvant Window-of-Opportunity Clinical Trial. Clin Cancer Res. 2017 May 01; 23(9):2186-2194. PMID: 28151720.
    Citations: 15     Fields:    Translation:HumansCellsCTClinical Trials
  49. Zolkind P, Dunn GP, Lin T, Griffith M, Griffith OL, Uppaluri R. Neoantigens in immunotherapy and personalized vaccines: Implications for head and neck squamous cell carcinoma. Oral Oncol. 2017 08; 71:169-176. PMID: 27751760.
    Citations: 9     Fields:    Translation:Humans
  50. Johanns TM, Miller CA, Dorward IG, Tsien C, Chang E, Perry A, Uppaluri R, Ferguson C, Schmidt RE, Dahiya S, Ansstas G, Mardis ER, Dunn GP. Immunogenomics of Hypermutated Glioblastoma: A Patient with Germline POLE Deficiency Treated with Checkpoint Blockade Immunotherapy. Cancer Discov. 2016 11; 6(11):1230-1236. PMID: 27683556.
    Citations: 131     Fields:    Translation:Humans
  51. Adkins D, Ley J, Michel L, Wildes TM, Thorstad W, Gay HA, Daly M, Rich J, Paniello R, Uppaluri R, Jackson R, Trinkaus K, Nussenbaum B. nab-Paclitaxel, cisplatin, and 5-fluorouracil followed by concurrent cisplatin and radiation for head and neck squamous cell carcinoma. Oral Oncol. 2016 10; 61:1-7. PMID: 27688097.
    Citations: 7     Fields:    Translation:HumansCTClinical Trials
  52. Uppaluri R, Bell RB, Sunwoo JB. Head and neck cancer immunology and immunotherapeutics: Basic concepts to clinical translational approaches. Oral Oncol. 2016 07; 58:49-51. PMID: 27238227.
    Citations:    Fields:    Translation:Humans
  53. Vermeer DW, Coppock JD, Zeng E, Lee KM, Spanos WC, Onken MD, Uppaluri R, Lee JH, Vermeer PD. Metastatic model of HPV+ oropharyngeal squamous cell carcinoma demonstrates heterogeneity in tumor metastasis. Oncotarget. 2016 Apr 26; 7(17):24194-207. PMID: 27013584.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  54. Moore EC, Cash HA, Caruso AM, Uppaluri R, Hodge JW, Van Waes C, Allen CT. Enhanced Tumor Control with Combination mTOR and PD-L1 Inhibition in Syngeneic Oral Cavity Cancers. Cancer Immunol Res. 2016 07; 4(7):611-20. PMID: 27076449.
    Citations: 42     Fields:    Translation:AnimalsCells
  55. Sylvester PT, Moran CJ, Derdeyn CP, Cross DT, Dacey RG, Zipfel GJ, Kim AH, Uppaluri R, Haughey BH, Tempelhoff R, Rich KM, Schneider J, Chole RA, Chicoine MR. Endovascular management of internal carotid artery injuries secondary to endonasal surgery: case series and review of the literature. J Neurosurg. 2016 11; 125(5):1256-1276. PMID: 26771847.
    Citations: 15     Fields:    Translation:Humans
  56. Cash H, Shah S, Moore E, Caruso A, Uppaluri R, Van Waes C, Allen C. mTOR and MEK1/2 inhibition differentially modulate tumor growth and the immune microenvironment in syngeneic models of oral cavity cancer. Oncotarget. 2015 Nov 03; 6(34):36400-17. PMID: 26506415.
    Citations: 28     Fields:    Translation:AnimalsCells
  57. Stepan KO, Sharma A, Chicoine MR, Uppaluri R, Dahiya S. Juvenile xanthogranuloma of supra-sellar region: a rare presentation. Clin Neuropathol. 2015 Nov-Dec; 34(6):368-70. PMID: 26308252.
    Citations: 1     Fields:    Translation:Humans
  58. Yang Z, Uppaluri R, Lewis JS. Ethmoid sinus mass. Sinonasal teratocarcinosarcoma. JAMA Otolaryngol Head Neck Surg. 2015 Apr; 141(4):389-90. PMID: 25695742.
    Citations: 1     Fields:    Translation:Humans
  59. Chalivendra V, Kanchi KL, Onken MD, Winkler AE, Mardis E, Uppaluri R. Genomic analysis to define molecular basis of aggressiveness in a mouse model of oral cancer. Genom Data. 2015 Mar 01; 3:61-62. PMID: 25729643.
    Citations: 5     
  60. Sylvester PT, Evans JA, Zipfel GJ, Chole RA, Uppaluri R, Haughey BH, Getz AE, Silverstein J, Rich KM, Kim AH, Dacey RG, Chicoine MR. Combined high-field intraoperative magnetic resonance imaging and endoscopy increase extent of resection and progression-free survival for pituitary adenomas. Pituitary. 2015 Feb; 18(1):72-85. PMID: 24599833.
    Citations: 17     Fields:    Translation:Humans
  61. Murillo-Sauca O, Chung MK, Shin JH, Karamboulas C, Kwok S, Jung YH, Oakley R, Tysome JR, Farnebo LO, Kaplan MJ, Sirjani D, Divi V, Holsinger FC, Tomeh C, Nichols A, Le QT, Colevas AD, Kong CS, Uppaluri R, Lewis JS, Ailles LE, Sunwoo JB. CD271 is a functional and targetable marker of tumor-initiating cells in head and neck squamous cell carcinoma. Oncotarget. 2014 Aug 30; 5(16):6854-66. PMID: 25149537.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  62. Onken MD, Winkler AE, Kanchi KL, Chalivendra V, Law JH, Rickert CG, Kallogjeri D, Judd NP, Dunn GP, Piccirillo JF, Lewis JS, Mardis ER, Uppaluri R. A surprising cross-species conservation in the genomic landscape of mouse and human oral cancer identifies a transcriptional signature predicting metastatic disease. Clin Cancer Res. 2014 Jun 01; 20(11):2873-84. PMID: 24668645.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  63. Lee SH, Carrero JA, Uppaluri R, White JM, Archambault JM, Lai KS, Chan SR, Sheehan KC, Unanue ER, Schreiber RD. Identifying the initiating events of anti-Listeria responses using mice with conditional loss of IFN-? receptor subunit 1 (IFNGR1). J Immunol. 2013 Oct 15; 191(8):4223-34. PMID: 24048899.
    Citations: 20     Fields:    Translation:AnimalsCells
  64. Allen CT, Law JH, Dunn GP, Uppaluri R. Emerging insights into head and neck cancer metastasis. Head Neck. 2013 Nov; 35(11):1669-78. PMID: 23280716.
    Citations: 21     Fields:    Translation:Humans
  65. O'Sullivan T, Saddawi-Konefka R, Vermi W, Koebel CM, Arthur C, White JM, Uppaluri R, Andrews DM, Ngiow SF, Teng MW, Smyth MJ, Schreiber RD, Bui JD. Cancer immunoediting by the innate immune system in the absence of adaptive immunity. J Exp Med. 2012 Sep 24; 209(10):1869-82. PMID: 22927549.
    Citations: 152     Fields:    Translation:AnimalsCells
  66. Judd NP, Allen CT, Winkler AE, Uppaluri R. Comparative analysis of tumor-infiltrating lymphocytes in a syngeneic mouse model of oral cancer. Otolaryngol Head Neck Surg. 2012 Sep; 147(3):493-500. PMID: 22434099.
    Citations: 31     Fields:    Translation:AnimalsCells
  67. Matsushita H, Vesely MD, Koboldt DC, Rickert CG, Uppaluri R, Magrini VJ, Arthur CD, White JM, Chen YS, Shea LK, Hundal J, Wendl MC, Demeter R, Wylie T, Allison JP, Smyth MJ, Old LJ, Mardis ER, Schreiber RD. Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting. Nature. 2012 Feb 08; 482(7385):400-4. PMID: 22318521.
    Citations: 527     Fields:    Translation:HumansAnimalsCells
  68. Allen CT, Judd NP, Bui JD, Uppaluri R. The clinical implications of antitumor immunity in head and neck cancer. Laryngoscope. 2012 Jan; 122(1):144-57. PMID: 22183634.
    Citations: 22     Fields:    Translation:Humans
  69. Judd NP, Winkler AE, Murillo-Sauca O, Brotman JJ, Law JH, Lewis JS, Dunn GP, Bui JD, Sunwoo JB, Uppaluri R. ERK1/2 regulation of CD44 modulates oral cancer aggressiveness. Cancer Res. 2012 Jan 01; 72(1):365-74. PMID: 22086849.
    Citations: 89     Fields:    Translation:AnimalsCells
  70. Winkler AE, Brotman JJ, Pittman ME, Judd NP, Lewis JS, Schreiber RD, Uppaluri R. CXCR3 enhances a T-cell-dependent epidermal proliferative response and promotes skin tumorigenesis. Cancer Res. 2011 Sep 01; 71(17):5707-16. PMID: 21734014.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  71. Hackman T, Rickert CG, Getz AE, Uppaluri R. Endoscopic surgical management of vidian nerve schwannoma. Laryngoscope. 2011 Feb; 121(2):241-4. PMID: 21271568.
    Citations: 4     Fields:    Translation:Humans
  72. Conforti R, Ma Y, Morel Y, Paturel C, Terme M, Viaud S, Ryffel B, Ferrantini M, Uppaluri R, Schreiber R, Combadière C, Chaput N, André F, Kroemer G, Zitvogel L. Opposing effects of toll-like receptor (TLR3) signaling in tumors can be therapeutically uncoupled to optimize the anticancer efficacy of TLR3 ligands. Cancer Res. 2010 Jan 15; 70(2):490-500. PMID: 20068181.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  73. Hackman T, Chicoine MR, Uppaluri R. Novel application of the palatal island flap for endoscopic skull base reconstruction. Laryngoscope. 2009 Aug; 119(8):1463-6. PMID: 19507226.
    Citations: 4     Fields:    Translation:Humans
  74. Uppaluri R, Dunn GP, Lewis JS. Focus on TILs: prognostic significance of tumor infiltrating lymphocytes in head and neck cancers. Cancer Immun. 2008 Dec 04; 8:16. PMID: 19053167.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  75. Uppaluri R, Sheehan KC, Wang L, Bui JD, Brotman JJ, Lu B, Gerard C, Hancock WW, Schreiber RD. Prolongation of cardiac and islet allograft survival by a blocking hamster anti-mouse CXCR3 monoclonal antibody. Transplantation. 2008 Jul 15; 86(1):137-47. PMID: 18622291.
    Citations: 37     Fields:    Translation:AnimalsCells
  76. Brenner MJ, Perrin RJ, Uppaluri R, Zipfel GJ, Lewis JS. Pathology quiz case 2. Atypical meningioma with clear cell features (World Health Organization [WHO] grade II). Arch Otolaryngol Head Neck Surg. 2008 Apr; 134(4):447-9. PMID: 18427017.
    Citations:    Fields:    Translation:Humans
  77. Dunn GP, Lewis JS, Sunwoo JB, Uppaluri R. Spontaneous regression of cutaneous head and neck melanoma: implications for the immunologic control of neoplasia. Head Neck. 2008 Feb; 30(2):267-72. PMID: 17657794.
    Citations: 4     Fields:    Translation:Humans
  78. Dunn GP, Uppaluri R, Hessler JL, Layland MK, Derdeyn CP, Sunwoo JB. Mycotic pseudoaneurysm of the internal maxillary artery: case report and review of the literature. Arch Otolaryngol Head Neck Surg. 2007 Apr; 133(4):402-6. PMID: 17438257.
    Citations: 2     Fields:    Translation:Humans
  79. Bui JD, Uppaluri R, Hsieh CS, Schreiber RD. Comparative analysis of regulatory and effector T cells in progressively growing versus rejecting tumors of similar origins. Cancer Res. 2006 Jul 15; 66(14):7301-9. PMID: 16849580.
    Citations: 49     Fields:    Translation:AnimalsCells
  80. Lieu JE, Muthappan PG, Uppaluri R. Association of reflux with otitis media in children. Otolaryngol Head Neck Surg. 2005 Sep; 133(3):357-61. PMID: 16143181.
    Citations: 11     Fields:    Translation:Humans
  81. Dunn GP, Bruce AT, Sheehan KC, Shankaran V, Uppaluri R, Bui JD, Diamond MS, Koebel CM, Arthur C, White JM, Schreiber RD. A critical function for type I interferons in cancer immunoediting. Nat Immunol. 2005 Jul; 6(7):722-9. PMID: 15951814.
    Citations: 224     Fields:    Translation:Animals
  82. Dunn GP, Ikeda H, Bruce AT, Koebel C, Uppaluri R, Bui J, Chan R, Diamond M, White JM, Sheehan KC, Schreiber RD. Interferon-gamma and cancer immunoediting. Immunol Res. 2005; 32(1-3):231-45. PMID: 16106075.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  83. Krug A, Uppaluri R, Facchetti F, Dorner BG, Sheehan KC, Schreiber RD, Cella M, Colonna M. IFN-producing cells respond to CXCR3 ligands in the presence of CXCL12 and secrete inflammatory chemokines upon activation. J Immunol. 2002 Dec 01; 169(11):6079-83. PMID: 12444109.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  84. Sun PC, Uppaluri R, Schmidt AP, Pashia ME, Quant EC, Sunwoo JB, Gollin SM, Scholnick SB. Transcript map of the 8p23 putative tumor suppressor region. Genomics. 2001 Jul; 75(1-3):17-25. PMID: 11472063.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.