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profileWojciech Stec, Ph.D.

TitleResearch Fellow in Anaesthesia (EXT)
InstitutionMassachusetts General Hospital
DepartmentAnaesthesia
AddressMassachusetts General Hospital
55 Fruit St
Boston MA 02114
Phone617/726-3030
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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Peciak J, Stec WJ, Treda C, Ksiazkiewicz M, Janik K, Popeda M, Smolarz M, Rosiak K, Hulas-Bigoszewska K, Och W, Rieske P, Stoczynska-Fidelus E. Low Incidence along with Low mRNA Levels of EGFRvIII in Prostate and Colorectal Cancers Compared to Glioblastoma. J Cancer. 2017; 8(1):146-151. PMID: 28123609.
    View in: PubMed
  2. Pawlowska R, Korczynski D, Nawrot B, Stec WJ, Chworos A. The a-thio and/or ß-?-hypophosphate analogs of ATP as cofactors of T4 DNA ligase. Bioorg Chem. 2016 Aug; 67:110-5. PMID: 27337226.
    View in: PubMed
  3. Stec WJ, Rosiak K, Siejka P, Peciak J, Popeda M, Banaszczyk M, Pawlowska R, Treda C, Hulas-Bigoszewska K, Piaskowski S, Stoczynska-Fidelus E, Rieske P. Cell line with endogenous EGFRvIII expression is a suitable model for research and drug development purposes. Oncotarget. 2016 May 31; 7(22):31907-25. PMID: 27004406.
    View in: PubMed
  4. Rosiak K, Smolarz M, Stec WJ, Peciak J, Grzela D, Winiecka-Klimek M, Stoczynska-Fidelus E, Krynska B, Piaskowski S, Rieske P. IDH1R132H in Neural Stem Cells: Differentiation Impaired by Increased Apoptosis. PLoS One. 2016; 11(5):e0154726. PMID: 27145078; PMCID: PMC4856348.
  5. Fisher KH, Stec W, Brown S, Zeidler MP. Mechanisms of JAK/STAT pathway negative regulation by the short coreceptor Eye Transformer/Latran. Mol Biol Cell. 2016 Feb 01; 27(3):434-41. PMID: 26658615; PMCID: PMC4751595.
  6. Krakowiak A, Pawlowska R, Kocon-Rebowska B, Dolot R, Stec WJ. Interactions of cellular histidine triad nucleotide binding protein 1 with nucleosides 5'-O-monophosphorothioate and their derivatives - Implication for desulfuration process in the cell. Biochim Biophys Acta. 2014 Dec; 1840(12):3357-66. PMID: 25199874.
    View in: PubMed
  7. Stec W, Vidal O, Zeidler MP. Drosophila SOCS36E negatively regulates JAK/STAT pathway signaling via two separable mechanisms. Mol Biol Cell. 2013 Sep; 24(18):3000-9. PMID: 23885117; PMCID: PMC3771960.
  8. Stec WJ, Zeidler MP. Drosophila SOCS Proteins. J Signal Transduct. 2011; 2011:894510. PMID: 22203896; PMCID: PMC3238392.
  9. Krakowiak A, Pecherzewska R, Kaczmarek R, Tomaszewska A, Nawrot B, Stec WJ. Evaluation of influence of Ap4A analogues on Fhit-positive HEK293T cells; cytotoxicity and ability to induce apoptosis. Bioorg Med Chem. 2011 Aug 15; 19(16):5053-60. PMID: 21757356.
    View in: PubMed
  10. Kulik K, Radzikowska E, Kaczmarek R, Baraniak J, Stec WJ, De Clercq E, Balzarini J, Pannecouque C. Synthesis and an antiviral activity evaluation of nucleoside 5´-O-(N-acyl) phosphoramidates. Antivir Chem Chemother. 2011; 21(3):143-50. PMID: 21233535.
    View in: PubMed
  11. Blaziak D, Guga P, Jagiello A, Korczynski D, Maciaszek A, Nowicka A, Pietkiewicz A, Stec WJ. Stereoselective formation of a P-P bond in the reaction of 2-alkoxy-2-thio-1,3,2-oxathiaphospholanes with O,O-dialkyl H-phosphonates and H-thiophosphonates. Org Biomol Chem. 2010 Dec 21; 8(24):5505-10. PMID: 20944857.
    View in: PubMed
  12. Tomaszewska A, Guga P, Stec WJ. Diastereomerically pure nucleoside-5'-O-(2-thio-4,4-pentamethylene-1,3,2-oxathiaphospholane)s--substrates for synthesis of P-chiral derivatives of nucleoside-5'-O-phosphorothioates. Chirality. 2011 Mar; 23(3):237-44. PMID: 20928893.
    View in: PubMed
  13. Vidal OM, Stec W, Bausek N, Smythe E, Zeidler MP. Negative regulation of Drosophila JAK-STAT signalling by endocytic trafficking. J Cell Sci. 2010 Oct 15; 123(Pt 20):3457-66. PMID: 20841381; PMCID: PMC2951467.
  14. Wojcik M, Stec WJ. The effect of divalent cations on the catalytic activity of the human plasma 3'-exonuclease. Biometals. 2010 Dec; 23(6):1113-21. PMID: 20589414.
    View in: PubMed
  15. Wang P, Chun BK, Rachakonda S, Du J, Khan N, Shi J, Stec W, Cleary D, Ross BS, Sofia MJ. An efficient and diastereoselective synthesis of PSI-6130: a clinically efficacious inhibitor of HCV NS5B polymerase. J Org Chem. 2009 Sep 04; 74(17):6819-24. PMID: 19642660.
    View in: PubMed
  16. Olesiak M, Stec WJ, Okruszek A. The synthesis of di- and oligo-nucleotides containing a phosphorodithioate internucleotide linkage with one of the sulfur atoms in a 5'-bridging position. Org Biomol Chem. 2009 May 21; 7(10):2162-9. PMID: 19421455.
    View in: PubMed
  17. Nawrot B, Paul N, Rebowska B, Stec WJ. Significance of stereochemistry of 3'-terminal phosphorothioate-modified primer in DNA polymerase-mediated chain extension. Mol Biotechnol. 2008 Oct; 40(2):119-26. PMID: 18769882.
    View in: PubMed
  18. Guranowski A, Wojdyla AM, Pietrowska-Borek M, Bieganowski P, Khurs EN, Cliff MJ, Blackburn GM, Blaziak D, Stec WJ. Fhit proteins can also recognize substrates other than dinucleoside polyphosphates. FEBS Lett. 2008 Sep 03; 582(20):3152-8. PMID: 18694747.
    View in: PubMed
  19. Wozniak LA, Góra M, Stec WJ. Chemoselective activation of nucleoside 3'-O-methylphosphonothioates with 1,3,5-triazinyl morpholinium salts. J Org Chem. 2007 Oct 26; 72(22):8584-7. PMID: 17915929.
    View in: PubMed
  20. Krakowiak A, Kaczmarek R, Baraniak J, Wieczorek M, Stec WJ. Stereochemistry of rHint1 hydrolase assisted cleavage of P-N bond in nucleoside 5'-O-phosphoramidothioates. Chem Commun (Camb). 2007 Jun 07; (21):2163-5. PMID: 17520123.
    View in: PubMed
  21. Nawrot B, Widera K, Wojcik M, Rebowska B, Nowak G, Stec WJ. Mapping of the functional phosphate groups in the catalytic core of deoxyribozyme 10-23. FEBS J. 2007 Feb; 274(4):1062-72. PMID: 17250742.
    View in: PubMed
  22. Guga P, Boczkowska M, Janicka M, Maciaszek A, Kuberski S, Stec WJ. Unusual thermal stability of RNA/[RP-PS]-DNA/RNA triplexes containing a homopurine DNA strand. Biophys J. 2007 Apr 01; 92(7):2507-15. PMID: 17218459; PMCID: PMC1864848.
  23. Wójcik M, Cieslak M, Stec WJ, Goding JW, Koziolkiewicz M. Nucleotide pyrophosphatase/phosphodiesterase 1 is responsible for degradation of antisense phosphorothioate oligonucleotides. Oligonucleotides. 2007; 17(1):134-45. PMID: 17461770.
    View in: PubMed
  24. Nawrot B, Sobczak M, Wójcik M, Janicka M, Nowak M, Cypryk M, Stec WJ. A novel class of DNA analogs bearing 5'-C-phosphonothymidine units: synthesis and physicochemical and biochemical properties. Oligonucleotides. 2006; 16(1):68-82. PMID: 16584296.
    View in: PubMed
  25. Guga P, Maciaszek A, Stec WJ. Oxathiaphospholane approach to the synthesis of oligodeoxyribonucleotides containing stereodefined internucleotide phosphoroselenoate function. Org Lett. 2005 Sep 01; 7(18):3901-4. PMID: 16119927.
    View in: PubMed
  26. Nagarajan R, Kwon K, Nawrot B, Stec WJ, Stivers JT. Catalytic phosphoryl interactions of topoisomerase IB. Biochemistry. 2005 Aug 30; 44(34):11476-85. PMID: 16114884.
    View in: PubMed
  27. Clark JL, Hollecker L, Mason JC, Stuyver LJ, Tharnish PM, Lostia S, McBrayer TR, Schinazi RF, Watanabe KA, Otto MJ, Furman PA, Stec WJ, Patterson SE, Pankiewicz KW. Design, synthesis, and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methylcytidine, a potent inhibitor of hepatitis C virus replication. J Med Chem. 2005 Aug 25; 48(17):5504-8. PMID: 16107149.
    View in: PubMed
  28. Misiura K, Szymanowicz D, Stec WJ. Synthesis of nucleoside alpha-thiotriphosphates via an oxathiaphospholane approach. Org Lett. 2005 May 26; 7(11):2217-20. PMID: 15901173.
    View in: PubMed
  29. Nawrot B, Michalak O, De Clercq E, Stec WJ. Analogues of acyclic nucleosides derived from tris-(hydroxymethyl)phosphine oxide or bis-(hydroxymethyl)phosphinic acid coupled to DNA nucleobases. Antivir Chem Chemother. 2004 Nov; 15(6):319-28. PMID: 15646645.
    View in: PubMed
  30. Kurpiewski MR, Engler LE, Wozniak LA, Kobylanska A, Koziolkiewicz M, Stec WJ, Jen-Jacobson L. Mechanisms of coupling between DNA recognition specificity and catalysis in EcoRI endonuclease. Structure. 2004 Oct; 12(10):1775-88. PMID: 15458627.
    View in: PubMed
  31. Zmudzka K, Nawrot B, Chojnacki T, Stec WJ. An oxathiaphospholane approach to one-pot phosphorothioylation of isoprenoid alcohols. Org Lett. 2004 Apr 29; 6(9):1385-7. PMID: 15101748.
    View in: PubMed
  32. Krakowiak A, Pace HC, Blackburn GM, Adams M, Mekhalfia A, Kaczmarek R, Baraniak J, Stec WJ, Brenner C. Biochemical, crystallographic, and mutagenic characterization of hint, the AMP-lysine hydrolase, with novel substrates and inhibitors. J Biol Chem. 2004 Apr 30; 279(18):18711-6. PMID: 14982931; PMCID: PMC2556070.
  33. Nawrot B, Antoszczyk S, Maszewska M, Kuwabara T, Warashina M, Taira K, Stec WJ. Efficient inhibition of beta-secretase gene expression in HEK293 cells by tRNAVal-driven and CTE-helicase associated hammerhead ribozymes. Eur J Biochem. 2003 Oct; 270(19):3962-70. PMID: 14511378.
    View in: PubMed
  34. Tonelli M, Ulyanov NB, Billeci TM, Karwowski B, Guga P, Stec WJ, James TL. Dynamic NMR structures of [Rp]- and [Sp]-phosphorothioated DNA-RNA hybrids: is flexibility required for RNase H recognition? Biophys J. 2003 Oct; 85(4):2525-38. PMID: 14507715; PMCID: PMC1303476.
  35. Guga P, Stec WJ. Synthesis of phosphorothioate oligonucleotides with stereodefined phosphorothioate linkages. Curr Protoc Nucleic Acid Chem. 2003 Oct; Chapter 4:Unit 4.17. PMID: 18428907.
    View in: PubMed
  36. Guranowski A, Starzynska E, McLennan AG, Baraniak J, Stec WJ. Adenosine-5'-O-phosphorylated and adenosine-5'-O-phosphorothioylated polyols as strong inhibitors of (symmetrical) and (asymmetrical) dinucleoside tetraphosphatases. Biochem J. 2003 Jul 15; 373(Pt 2):635-40. PMID: 12697025; PMCID: PMC1223503.
  37. Owczarek A, Kaczmarek R, Mikolajczyk B, Wasilewska E, Korczynski D, Baraniak J, Koziolkiewicz M, Stec WJ, Brenner C. Stereochemical analysis of diastereomeric 1,3-bis(adenosine-5'-O-phosphorothioyl)glycerols. Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug; 22(5-8):797-9. PMID: 14565281.
    View in: PubMed
  38. Krieg AM, Guga P, Stec W. P-chirality-dependent immune activation by phosphorothioate CpG oligodeoxynucleotides. Oligonucleotides. 2003; 13(6):491-9. PMID: 15025915.
    View in: PubMed
  39. Krakowiak A, Owczarek A, Koziolkiewicz M, Stec WJ. Stereochemical course of Escherichia coli RNase H. Chembiochem. 2002 Dec 02; 3(12):1242-50. PMID: 12465033.
    View in: PubMed
  40. Boczkowska M, Guga P, Stec WJ. Stereodefined phosphorothioate analogues of DNA: relative thermodynamic stability of the model PS-DNA/DNA and PS-DNA/RNA complexes. Biochemistry. 2002 Oct 15; 41(41):12483-7. PMID: 12369839.
    View in: PubMed
  41. Inagawa T, Nakashima H, Karwowski B, Guga P, Stec WJ, Takeuchi H, Takaku H. Inhibition of human immunodeficiency virus type 1 replication by P-stereodefined oligo(nucleoside phosphorothioate)s in a long-term infection model. FEBS Lett. 2002 Sep 25; 528(1-3):48-52. PMID: 12297278.
    View in: PubMed
  42. Walkowiak B, Baraniak J, Cierniewski CS, Stec W. Inhibition of ADP-triggered blood platelet aggregation by diadenosine polyphosphate analogues. Bioorg Med Chem Lett. 2002 Aug 05; 12(15):1959-62. PMID: 12113818.
    View in: PubMed
  43. Koziolkiewicz M, Owczarek A, Wójcik M, Domanski K, Guga P, Stec WJ. Retention of configuration in the action of human plasma 3'-exonuclease on oligo(deoxynucleoside phosphorothioate). A new method for assignment of absolute configuration at phosphorus in isotopomeric deoxyadenosine 5'-O-[(18)O]phosphorothioate. J Am Chem Soc. 2002 May 01; 124(17):4623-7. PMID: 11971710.
    View in: PubMed
  44. Chworos A, Wozniak LA, Stec WJ. New examples of mixed seleno-sulfides; reactions with triphenylphosphine. Chem Commun (Camb). 2002 Mar 07; (5):518-9. PMID: 12120569.
    View in: PubMed
  45. Da Costa CP, Krajewska D, Okruszek A, Stec WJ, Sigel H. Stabilities of lead(II) complexes formed in aqueous solution with methyl thiophosphate (MeOPS(2-)), uridine 5'- O-thiomonophosphate (UMPS(2-)) or adenosine 5'- O-thiomonophosphate (AMPS(2-)). J Biol Inorg Chem. 2002 Apr; 7(4-5):405-15. PMID: 11941498.
    View in: PubMed
  46. Nawrot B, Antoszczyk S, Maszewska M, Rebowski G, Kuwabara T, Warashina M, Taira K, Stec WJ. Modulation of beta-secretase gene expression by action of catalytic nucleic acids. Nucleic Acids Res Suppl. 2002; (2):105-6. PMID: 12903127.
    View in: PubMed
  47. Cieslak M, Niewiarowska J, Nawrot M, Koziolkiewicz M, Stec WJ, Cierniewski CS. DNAzymes to beta 1 and beta 3 mRNA down-regulate expression of the targeted integrins and inhibit endothelial cell capillary tube formation in fibrin and matrigel. J Biol Chem. 2002 Mar 01; 277(9):6779-87. PMID: 11675378.
    View in: PubMed
  48. Guga P, Domański K, Stec WJ. Oxathiaphospholane Approach to the Synthesis of P-Chiral, Isotopomeric Deoxy(ribonucleoside phosphorothioate)s and Phosphates Labeled with an Oxygen Isotope This work was financially supported by the State Committee for Scientific Research (KBN, Poland, Grant 4P05F00617, to W.J.S.), and, in part, by the Human Science Promotion Foundation (Japan, to H. Takaku and W.J.S.). Angew Chem Int Ed Engl. 2001 Feb 02; 40(3):610-613. PMID: 11180387.
    View in: PubMed
  49. Varnum JM, Baraniak J, Kaczmarek R, Stec WJ, Brenner C. Di-, tri- and tetra-5'-O-phosphorothioadenosyl substituted polyols as inhibitors of Fhit: Importance of the alpha-beta bridging oxygen and beta phosphorus replacement. BMC Chem Biol. 2001; 1(1):3. PMID: 11701096.
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  50. Yang XB, Sierzchala A, Misiura K, Niewiarowski W, Sochacki M, Stec WJ, Wieczorek MW. The First Stereocontrolled Solid-Phase Synthesis of Di-, Tri-, and Tetra[adenosine (2',5') phosphorothioate]s. J Org Chem. 1998 Oct 02; 63(20):7097-7100. PMID: 11672339.
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  51. Okruszek A, Olesiak M, Krajewska D, Stec WJ. Efficient One-Pot Synthesis of 2'-Deoxyribonucleoside 3'-O- and 5'-O-Phosphorodithioates. J Org Chem. 1997 Apr 04; 62(7):2269-2272. PMID: 11671541.
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  52. Sierzchala A, Okruszek A, Stec WJ. Oxathiaphospholane Method of Stereocontrolled Synthesis of Diribonucleoside 3',5'-Phosphorothioates. J Org Chem. 1996 Sep 20; 61(19):6713-6716. PMID: 11667545.
    View in: PubMed
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