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Yiheng Tu, Ph.D.

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The University of Hong Kong, Hong KongPhD08/2016Biomedical Engineering

My research to-date has focused on studying the neurologic signatures of brain diseases using neuroimaging techniques including EEG, MEG, and fMRI, and subsequently helping in clinical diagnosis for doctors. I am also interested in investigating the neural mechanisms of human pain perception and developing objective pain measurements using neuroimaging techniques.

In contrast to conventional neuroimaging studies which test hypotheses about structure-function associations in the brain, my work concentrates on using multivariate, data-driven methods to provide a basis for reconceptualizing diagnostic categories that are useful for clinical decision-making and identifying neuropathological features for therapeutic development. Therefore, my focus is not on whether there are any effects in one or more brain regions, but on whether the effects are large enough to have clinical utility.

I have substantial experiences in bridging the state-of-the-art machine learning techniques and neuroimaging applications to study neuroscience and clinical problems.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Cao J, Tu Y, Lang C, Vangel M, Park J, Liu J, Wilson G, Gollub R, Orr S, Kong J. Daily Caffeine Consumption Does Not Influence Acupuncture Analgesia in Healthy Individuals: A Preliminary Study. Anesth Analg. 2021 01 01; 132(1):e6-e9. PMID: 30585904.
    Citations:    Fields:    Translation:Humans
  2. Tu Y, Bi Y, Zhang L, Wei H, Hu L. Mesocorticolimbic Pathways Encode Cue-Based Expectancy Effects on Pain. J Neurosci. 2020 01 08; 40(2):382-394. PMID: 31694965.
    Citations: 3     Fields:    Translation:Humans
  3. Liu J, Chen L, Tu Y, Chen X, Hu K, Tu Y, Lin M, Xie G, Chen S, Huang J, Liu W, Wu J, Xiao T, Wilson G, Lang C, Park J, Tao J, Kong J. Different exercise modalities relieve pain syndrome in patients with knee osteoarthritis and modulate the dorsolateral prefrontal cortex: A multiple mode MRI study. Brain Behav Immun. 2019 Nov; 82:253-263. PMID: 31472246.
    Citations: 3     Fields:    Translation:Humans
  4. Tu Y, Zhang B, Cao J, Wilson G, Zhang Z, Kong J. Identifying inter-individual differences in pain threshold using brain connectome: a test-retest reproducible study. Neuroimage. 2019 11 15; 202:116049. PMID: 31349067.
    Citations: 7     Fields:    Translation:Humans
  5. Cao J, Tu Y, Orr SP, Lang C, Park J, Vangel M, Chen L, Gollub R, Kong J. Analgesic Effects Evoked by Real and Imagined Acupuncture: A Neuroimaging Study. Cereb Cortex. 2019 07 22; 29(8):3220-3231. PMID: 30137262.
    Citations: 8     Fields:    Translation:Humans
  6. Tu Y, Jung M, Gollub RL, Napadow V, Gerber J, Ortiz A, Lang C, Mawla I, Shen W, Chan ST, Wasan AD, Edwards RR, Kaptchuk TJ, Rosen B, Kong J. Abnormal medial prefrontal cortex functional connectivity and its association with clinical symptoms in chronic low back pain. Pain. 2019 06; 160(6):1308-1318. PMID: 31107712.
    Citations: 15     Fields:    Translation:Humans
  7. Jung M, Tu Y, Park J, Jorgenson K, Lang C, Song W, Kong J. Surface-based shared and distinct resting functional connectivity in attention-deficit hyperactivity disorder and autism spectrum disorder. Br J Psychiatry. 2019 06; 214(6):339-344. PMID: 31088591.
    Citations: 8     Fields:    Translation:Humans
  8. Tu Y, Fu Z, Maleki N. When does the youthfulness of the female brain emerge? Proc Natl Acad Sci U S A. 2019 05 28; 116(22):10632-10633. PMID: 31138714.
    Citations: 2     Fields:    Translation:Humans
  9. Tu Y, Ortiz A, Gollub RL, Cao J, Gerber J, Lang C, Park J, Wilson G, Shen W, Chan ST, Wasan AD, Edwards RR, Napadow V, Kaptchuk TJ, Rosen B, Kong J. Multivariate resting-state functional connectivity predicts responses to real and sham acupuncture treatment in chronic low back pain. Neuroimage Clin. 2019; 23:101885. PMID: 31176295.
    Citations: 12     Fields:    Translation:Humans
  10. Tu Y, Fu Z, Zeng F, Maleki N, Lan L, Li Z, Park J, Wilson G, Gao Y, Liu M, Calhoun V, Liang F, Kong J. Abnormal thalamocortical network dynamics in migraine. Neurology. 2019 06 04; 92(23):e2706-e2716. PMID: 31076535.
    Citations: 18     Fields:    Translation:Humans
  11. Maleki N, Cheng YC, Tu Y, Locascio JJ. Longitudinal course of vasomotor symptoms in perimenopausal migraineurs. Ann Neurol. 2019 06; 85(6):865-874. PMID: 30937949.
    Citations: 2     Fields:    Translation:Humans
  12. Zhang B, Jung M, Tu Y, Gollub R, Lang C, Ortiz A, Park J, Wilson G, Gerber J, Mawla I, Chan ST, Wasan A, Edwards R, Lee J, Napadow V, Kaptchuk T, Rosen B, Kong J. Identifying brain regions associated with the neuropathology of chronic low back pain: a resting-state amplitude of low-frequency fluctuation study. Br J Anaesth. 2019 Aug; 123(2):e303-e311. PMID: 30948036.
    Citations: 13     Fields:    Translation:Humans
  13. Shen W, Tu Y, Gollub RL, Ortiz A, Napadow V, Yu S, Wilson G, Park J, Lang C, Jung M, Gerber J, Mawla I, Chan ST, Wasan AD, Edwards RR, Kaptchuk T, Li S, Rosen B, Kong J. Visual network alterations in brain functional connectivity in chronic low back pain: A resting state functional connectivity and machine learning study. Neuroimage Clin. 2019; 22:101775. PMID: 30927604.
    Citations: 13     Fields:    Translation:Humans
  14. Liu J, Tao J, Liu W, Huang J, Xue X, Li M, Yang M, Zhu J, Lang C, Park J, Tu Y, Wilson G, Chen L, Kong J. Different modulation effects of Tai Chi Chuan and Baduanjin on resting-state functional connectivity of the default mode network in older adults. Soc Cogn Affect Neurosci. 2019 02 13; 14(2):217-224. PMID: 30690554.
    Citations: 10     Fields:    Translation:Humans
  15. Wan G, Kong X, Sun B, Yu S, Tu Y, Park J, Lang C, Koh M, Wei Z, Feng Z, Lin Y, Kong J. Applying Eye Tracking to Identify Autism Spectrum Disorder in Children. J Autism Dev Disord. 2019 Jan; 49(1):209-215. PMID: 30097760.
    Citations: 5     Fields:    Translation:Humans
  16. Chen J, Wang Z, Tu Y, Liu X, Jorgenson K, Ye G, Lin C, Liu J, Park J, Lang C, Liu B, Kong J. Regional Homogeneity and Multivariate Pattern Analysis of Cervical Spondylosis Neck Pain and the Modulation Effect of Treatment. Front Neurosci. 2018; 12:900. PMID: 30574062.
    Citations: 3     
  17. Tu Y, Park J, Ahlfors SP, Khan S, Egorova N, Lang C, Cao J, Kong J. A neural mechanism of direct and observational conditioning for placebo and nocebo responses. Neuroimage. 2019 01 01; 184:954-963. PMID: 30296557.
    Citations: 6     Fields:    Translation:Humans
  18. Wang Y, Fang J, Song P, Bao Y, Song W, Liu J, Lang C, Jorgenson K, Jung M, Shen D, Li S, Sun R, Ding X, Yang J, Meng X, Wang N, Yan Z, Yan Y, Kong Q, Dong Y, Cui F, Tu Y, Cui B, Kong J. The Dysfunction of the Cerebellum and Its Cerebellum-Reward-Sensorimotor Loops in Chronic Spontaneous Urticaria. Cerebellum. 2018 Oct; 17(5):507-516. PMID: 29574551.
    Citations: 2     Fields:    Translation:Humans
  19. Fu Z, Tu Y, Di X, Du Y, Sui J, Biswal BB, Zhang Z, de Lacy N, Calhoun VD. Transient increased thalamic-sensory connectivity and decreased whole-brain dynamism in autism. Neuroimage. 2019 04 15; 190:191-204. PMID: 29883735.
    Citations: 25     Fields:    Translation:Humans
  20. Tu Y, Fang J, Cao J, Wang Z, Park J, Jorgenson K, Lang C, Liu J, Zhang G, Zhao Y, Zhu B, Rong P, Kong J. A distinct biomarker of continuous transcutaneous vagus nerve stimulation treatment in major depressive disorder. Brain Stimul. 2018 May - Jun; 11(3):501-508. PMID: 29398576.
    Citations: 13     Fields:    Translation:Humans
  21. Tu Y, Fu Z, Tan A, Huang G, Hu L, Hung YS, Zhang Z. A novel and effective fMRI decoding approach based on sliced inverse regression and its application to pain prediction. Neurocomputing. 2018; 273:373-384. View Publication.
  22. Gollub RL, Kirsch I, Maleki N, Wasan AD, Edwards RR, Tu Y, Kaptchuk TJ, Kong J. A Functional Neuroimaging Study of Expectancy Effects on Pain Response in Patients With Knee Osteoarthritis. J Pain. 2018 05; 19(5):515-527. PMID: 29325883.
    Citations: 13     Fields:    Translation:Humans
  23. Fu Z, Tu Y, Di X, Biswal BB, Calhoun VD, Zhang Z. Associations between Functional Connectivity Dynamics and BOLD Dynamics Are Heterogeneous Across Brain Networks. Front Hum Neurosci. 2017; 11:593. PMID: 29375335.
    Citations: 2     
  24. Fu Z, Tu Y, Di X, Du Y, Pearlson GD, Turner JA, Biswal BB, Zhang Z, Calhoun VD. Characterizing dynamic amplitude of low-frequency fluctuation and its relationship with dynamic functional connectivity: An application to schizophrenia. Neuroimage. 2018 10 15; 180(Pt B):619-631. PMID: 28939432.
    Citations: 41     Fields:    Translation:Humans
  25. Jung M, Tu Y, Lang CA, Ortiz A, Park J, Jorgenson K, Kong XJ, Kong J. Decreased structural connectivity and resting-state brain activity in the lateral occipital cortex is associated with social communication deficits in boys with autism spectrum disorder. Neuroimage. 2019 04 15; 190:205-212. PMID: 28927730.
    Citations: 11     Fields:    Translation:Humans
  26. Tan A, Hu L, Tu Y, Chen R, Hung YS, Zhang Z. N1 Magnitude of Auditory Evoked Potentials and Spontaneous Functional Connectivity Between Bilateral Heschl's Gyrus Are Coupled at Interindividual Level. Brain Connect. 2016 07; 6(6):496-504. PMID: 27105665.
    Citations: 2     Fields:    Translation:Humans
  27. Tu Y, Tan A, Bai Y, Hung YS, Zhang Z. Decoding Subjective Intensity of Nociceptive Pain from Pre-stimulus and Post-stimulus Brain Activities. Front Comput Neurosci. 2016; 10:32. PMID: 27148029.
    Citations: 13     
  28. Bai Y, Huang G, Tu Y, Tan A, Hung YS, Zhang Z. Normalization of Pain-Evoked Neural Responses Using Spontaneous EEG Improves the Performance of EEG-Based Cross-Individual Pain Prediction. Front Comput Neurosci. 2016; 10:31. PMID: 27148028.
    Citations: 4     
  29. Tu Y, Zhang Z, Tan A, Peng W, Hung YS, Moayedi M, Iannetti GD, Hu L. Alpha and gamma oscillation amplitudes synergistically predict the perception of forthcoming nociceptive stimuli. Hum Brain Mapp. 2016 Feb; 37(2):501-14. PMID: 26523484.
    Citations: 31     Fields:    Translation:Humans
  30. Supervised nonlinear dimension reduction of functional magnetic resonance imaging data using Sliced Inverse Regression. Annu Int Conf IEEE Eng Med Biol Soc. 2015 Aug; 2015:2641-4. PMID: 26736834.
    Citations: 3     
  31. L0-regularized time-varying sparse inverse covariance estimation for tracking dynamic fMRI brain networks. Annu Int Conf IEEE Eng Med Biol Soc. 2015 Aug; 2015:1496-9. PMID: 26736554.
    Citations: 1     
  32. Joint collaborative representation based sleep stage classification with multi-channel EEG signals. Annu Int Conf IEEE Eng Med Biol Soc. 2015 Aug; 2015:590-3. PMID: 26736331.
    Citations:    Translation:Humans
  33. Tan A, Fu Z, Tu Y, Hung YS, Zhang Z. Joint source separation of simultaneous EEG-fMRI recording in two experimental conditions using common spatial patterns. Annu Int Conf IEEE Eng Med Biol Soc. 2015; 2015:2633-6. PMID: 26736832.
    Citations:    Translation:Humans
  34. Tu Y, Hung YS, Hu L, Huang G, Hu Y, Zhang Z. An automated and fast approach to detect single-trial visual evoked potentials with application to brain-computer interface. Clin Neurophysiol. 2014 Dec; 125(12):2372-83. PMID: 24794514.
    Citations: 3     Fields:    Translation:Humans
  35. Tu Y, Huang G, Hung YS, Hu L, Hu Y, Zhang Z. Single-trial detection of visual evoked potentials by common spatial patterns and wavelet filtering for brain-computer interface. Annu Int Conf IEEE Eng Med Biol Soc. 2013; 2013:2882-5. PMID: 24110329.
    Citations: 1     Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.