Harvard Catalyst Profiles

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Giorgio Enrico Maria Melloni, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Marston NA, Pirruccello JP, Melloni GEM, Koyama S, Kamanu FK, Weng LC, Roselli C, Kamatani Y, Komuro I, Aragam KG, Butterworth AS, Ito K, Lubitz SA, Ellinor PT, Sabatine MS, Ruff CT. Predictive Utility of a Coronary Artery Disease Polygenic Risk Score in Primary Prevention. JAMA Cardiol. 2023 02 01; 8(2):130-137. PMID: 36576811; PMCID: PMC9857431.
    Citations:    Fields:    Translation:HumansPHPublic Health
  2. Halford JL, Morrill VN, Choi SH, Jurgens SJ, Melloni G, Marston NA, Weng LC, Nauffal V, Hall AW, Gunn S, Austin-Tse CA, Pirruccello JP, Khurshid S, Rehm HL, Benjamin EJ, Boerwinkle E, Brody JA, Correa A, Fornwalt BK, Gupta N, Haggerty CM, Harris S, Heckbert SR, Hong CC, Kooperberg C, Lin HJ, Loos RJF, Mitchell BD, Morrison AC, Post W, Psaty BM, Redline S, Rice KM, Rich SS, Rotter JI, Schnatz PF, Soliman EZ, Sotoodehnia N, Wong EK, Sabatine MS, Ruff CT, Lunetta KL, Ellinor PT, Lubitz SA. Publisher Correction: Endophenotype effect sizes support variant pathogenicity in monogenic disease susceptibility genes. Nat Commun. 2022 Sep 30; 13(1):5767. PMID: 36180445; PMCID: PMC9525665.
    Citations:    Fields:    
  3. Halford JL, Morrill VN, Choi SH, Jurgens SJ, Melloni G, Marston NA, Weng LC, Nauffal V, Hall AW, Gunn S, Austin-Tse CA, Pirruccello JP, Khurshid S, Rehm HL, Benjamin EJ, Boerwinkle E, Brody JA, Correa A, Fornwalt BK, Gupta N, Haggerty CM, Harris S, Heckbert SR, Hong CC, Kooperberg C, Lin HJ, Loos RJF, Mitchell BD, Morrison AC, Post W, Psaty BM, Redline S, Rice KM, Rich SS, Rotter JI, Schnatz PF, Soliman EZ, Sotoodehnia N, Wong EK, Sabatine MS, Ruff CT, Lunetta KL, Ellinor PT, Lubitz SA. Endophenotype effect sizes support variant pathogenicity in monogenic disease susceptibility genes. Nat Commun. 2022 08 30; 13(1):5106. PMID: 36042188; PMCID: PMC9427940.
    Citations:    Fields:    Translation:Humans
  4. Marston NA, Giugliano RP, Melloni GEM, Park JG, Morrill V, Blazing MA, Ference B, Stein E, Stroes ES, Braunwald E, Ellinor PT, Lubitz SA, Ruff CT, Sabatine MS. Association of Apolipoprotein B-Containing Lipoproteins and Risk of Myocardial Infarction in Individuals With and Without Atherosclerosis: Distinguishing Between Particle Concentration, Type, and Content. JAMA Cardiol. 2022 Mar 01; 7(3):250-256. PMID: 34773460; PMCID: PMC8590731.
    Citations: 13     Fields:    Translation:Humans
  5. Cook JH, Melloni GEM, Gulhan DC, Park PJ, Haigis KM. The origins and genetic interactions of KRAS mutations are allele- and tissue-specific. Nat Commun. 2021 03 22; 12(1):1808. PMID: 33753749; PMCID: PMC7985210.
    Citations: 35     Fields:    Translation:Humans
  6. Marston NA, Melloni GEM, Gurmu Y, Bonaca MP, Kamanu FK, Roselli C, Lee C, Cavallari I, Giugliano RP, Scirica BM, Bhatt DL, Steg PG, Cohen M, Storey RF, Keech AC, Raz I, Mosenzon O, Braunwald E, Lubitz SA, Ellinor PT, Sabatine MS, Ruff CT. Genetic Risk Score to Identify Risk of Venous Thromboembolism in Patients With Cardiometabolic Disease. Circ Genom Precis Med. 2021 02; 14(1):e003006. PMID: 33434447; PMCID: PMC7887088.
    Citations: 2     Fields:    Translation:Humans
  7. Marston NA, Gurmu Y, Melloni GEM, Bonaca M, Gencer B, Sever PS, Pedersen TR, Keech AC, Roselli C, Lubitz SA, Ellinor PT, O'Donoghue ML, Giugliano RP, Ruff CT, Sabatine MS. The Effect of PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) Inhibition on the Risk of Venous Thromboembolism. Circulation. 2020 05 19; 141(20):1600-1607. PMID: 32223429; PMCID: PMC7469753.
    Citations: 27     Fields:    Translation:Humans
  8. Dellino GI, Palluzzi F, Chiariello AM, Piccioni R, Bianco S, Furia L, De Conti G, Bouwman BAM, Melloni G, Guido D, Giacò L, Luzi L, Cittaro D, Faretta M, Nicodemi M, Crosetto N, Pelicci PG. Release of paused RNA polymerase II at specific loci favors DNA double-strand-break formation and promotes cancer translocations. Nat Genet. 2019 06; 51(6):1011-1023. PMID: 31110352.
    Citations: 43     Fields:    Translation:AnimalsCells
  9. Gulhan DC, Lee JJ, Melloni GEM, Cortés-Ciriano I, Park PJ. Detecting the mutational signature of homologous recombination deficiency in clinical samples. Nat Genet. 2019 05; 51(5):912-919. PMID: 30988514.
    Citations: 95     Fields:    Translation:HumansCells
  10. Melloni GEM, Guida A, Curigliano G, Botteri E, Esposito A, Kamal M, Le Tourneau C, Riva L, Magi A, de Maria R, Pelicci P, Mazzarella L. Precision Trial Drawer, a Computational Tool to Assist Planning of Genomics-Driven Trials in Oncology. JCO Precis Oncol. 2018 Nov; 2:1-16. PMID: 35135136.
    Citations:    Fields:    
  11. Richichi C, Fornasari L, Melloni GEM, Brescia P, Patanè M, Del Bene M, Mustafa DAM, Kros JM, Pollo B, Pruneri G, Sciandivasci A, Munzone E, DiMeco F, Pelicci PG, Riva L, Pelicci G. Mutations targeting the coagulation pathway are enriched in brain metastases. Sci Rep. 2017 07 26; 7(1):6573. PMID: 28747664.
    Citations: 6     Fields:    Translation:Humans
  12. Melloni GEM, Mazzarella L, Bernard L, Bodini M, Russo A, Luzi L, Pelicci PG, Riva L. A knowledge-based framework for the discovery of cancer-predisposing variants using large-scale sequencing breast cancer data. Breast Cancer Res. 2017 05 31; 19(1):63. PMID: 28569218; PMCID: PMC5452392.
    Citations: 1     Fields:    Translation:Humans
  13. Melloni GE, de Pretis S, Riva L, Pelizzola M, Céol A, Costanza J, Müller H, Zammataro L. LowMACA: exploiting protein family analysis for the identification of rare driver mutations in cancer. BMC Bioinformatics. 2016 Feb 09; 17:80. PMID: 26860319; PMCID: PMC4748640.
    Citations: 6     Fields:    Translation:Humans
  14. de Pretis S, Kress T, Morelli MJ, Melloni GE, Riva L, Amati B, Pelizzola M. INSPEcT: a computational tool to infer mRNA synthesis, processing and degradation dynamics from RNA- and 4sU-seq time course experiments. Bioinformatics. 2015 Sep 01; 31(17):2829-35. PMID: 25957348.
    Citations: 30     Fields:    Translation:AnimalsCells
  15. Bodini M, Ronchini C, Giacò L, Russo A, Melloni GE, Luzi L, Sardella D, Volorio S, Hasan SK, Ottone T, Lavorgna S, Lo-Coco F, Candoni A, Fanin R, Toffoletti E, Iacobucci I, Martinelli G, Cignetti A, Tarella C, Bernard L, Pelicci PG, Riva L. The hidden genomic landscape of acute myeloid leukemia: subclonal structure revealed by undetected mutations. Blood. 2015 Jan 22; 125(4):600-5. PMID: 25499761; PMCID: PMC4304104.
    Citations: 11     Fields:    Translation:Humans
  16. Melloni GE, Ogier AG, de Pretis S, Mazzarella L, Pelizzola M, Pelicci PG, Riva L. DOTS-Finder: a comprehensive tool for assessing driver genes in cancer genomes. Genome Med. 2014; 6(6):44. PMID: 25690659.
    Citations: 12     Fields:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.