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Aya Nambu, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Jasenosky LD, Nambu A, Tsytsykova AV, Ranjbar S, Haridas V, Kruidenier L, Tough DF, Goldfeld AE. Identification of a Distal Locus Enhancer Element That Controls Cell Type-Specific TNF and LTA Gene Expression in Human T Cells. J Immunol. 2020 11 01; 205(9):2479-2488. PMID: 32978279.
    Citations:    Fields:    Translation:HumansCells
  2. Yoshizaki T, Itoh S, Yamaguchi S, Numata T, Nambu A, Kimura N, Suto H, Okumura K, Sudo K, Yamaguchi A, Nakae S. IL-25 exacerbates autoimmune aortitis in IL-1 receptor antagonist-deficient mice. Sci Rep. 2019 11 19; 9(1):17067. PMID: 31745167.
    Citations:    Fields:    Translation:AnimalsCells
  3. Ranjbar S, Haridas V, Nambu A, Jasenosky LD, Sadhukhan S, Ebert TS, Hornung V, Cassell GH, Falvo JV, Goldfeld AE. Cytoplasmic RNA Sensor Pathways and Nitazoxanide Broadly Inhibit Intracellular Mycobacterium tuberculosis Growth. iScience. 2019 Dec 20; 22:299-313. PMID: 31805434.
    Citations: 8     
  4. Langston PK, Nambu A, Jung J, Shibata M, Aksoylar HI, Lei J, Xu P, Doan MT, Jiang H, MacArthur MR, Gao X, Kong Y, Chouchani ET, Locasale JW, Snyder NW, Horng T. Author Correction: Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses. Nat Immunol. 2019 Nov; 20(11):1555. PMID: 31551573.
    Citations: 1     Fields:    
  5. Jasenosky LD, Cadena C, Mire CE, Borisevich V, Haridas V, Ranjbar S, Nambu A, Bavari S, Soloveva V, Sadukhan S, Cassell GH, Geisbert TW, Hur S, Goldfeld AE. The FDA-Approved Oral Drug Nitazoxanide Amplifies Host Antiviral Responses and Inhibits Ebola Virus. iScience. 2019 Sep 27; 19:1279-1290. PMID: 31402258.
    Citations: 33     
  6. Langston PK, Nambu A, Jung J, Shibata M, Aksoylar HI, Lei J, Xu P, Doan MT, Jiang H, MacArthur MR, Gao X, Kong Y, Chouchani ET, Locasale JW, Snyder NW, Horng T. Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses. Nat Immunol. 2019 09; 20(9):1186-1195. PMID: 31384058.
    Citations: 29     Fields:    Translation:AnimalsCells
  7. Hiraishi Y, Yamaguchi S, Yoshizaki T, Nambu A, Shimura E, Takamori A, Narushima S, Nakanishi W, Asada Y, Numata T, Suzukawa M, Yamauchi Y, Matsuda A, Arae K, Morita H, Hoshino T, Suto H, Okumura K, Matsumoto K, Saito H, Sudo K, Iikura M, Nagase T, Nakae S. IL-33, IL-25 and TSLP contribute to development of fungal-associated protease-induced innate-type airway inflammation. Sci Rep. 2018 12 21; 8(1):18052. PMID: 30575775.
    Citations: 7     Fields:    Translation:Animals
  8. Kim J, Ishiguro KI, Nambu A, Akiyoshi B, Yokobayashi S, Kagami A, Ishiguro T, Pendas AM, Takeda N, Sakakibara Y, Kitajima TS, Tanno Y, Sakuno T, Watanabe Y. Author Correction: Meikin is a conserved regulator of meiosis-I-specific kinetochore function. Nature. 2018 11; 563(7731):E23. PMID: 30275477.
    Citations:    Fields:    
  9. Yamaguchi S, Nambu A, Numata T, Yoshizaki T, Narushima S, Shimura E, Hiraishi Y, Arae K, Morita H, Matsumoto K, Hisatome I, Sudo K, Nakae S. The roles of IL-17C in T cell-dependent and -independent inflammatory diseases. Sci Rep. 2018 10 24; 8(1):15750. PMID: 30356086.
    Citations: 7     Fields:    Translation:AnimalsCells
  10. Takamori A, Nambu A, Sato K, Yamaguchi S, Matsuda K, Numata T, Sugawara T, Yoshizaki T, Arae K, Morita H, Matsumoto K, Sudo K, Okumura K, Kitaura J, Matsuda H, Nakae S. IL-31 is crucial for induction of pruritus, but not inflammation, in contact hypersensitivity. Sci Rep. 2018 04 27; 8(1):6639. PMID: 29703903.
    Citations: 12     Fields:    Translation:AnimalsCells
  11. Suto H, Nambu A, Morita H, Yamaguchi S, Numata T, Yoshizaki T, Shimura E, Arae K, Asada Y, Motomura K, Kaneko M, Abe T, Matsuda A, Iwakura Y, Okumura K, Saito H, Matsumoto K, Sudo K, Nakae S. IL-25 enhances TH17 cell-mediated contact dermatitis by promoting IL-1ß production by dermal dendritic cells. J Allergy Clin Immunol. 2018 11; 142(5):1500-1509.e10. PMID: 29522843.
    Citations: 5     Fields:    Translation:AnimalsCells
  12. Kim JH, Lee E, Friedline RH, Suk S, Jung DY, Dagdeviren S, Hu X, Inashima K, Noh HL, Kwon JY, Nambu A, Huh JR, Han MS, Davis RJ, Lee AS, Lee KW, Kim JK. Endoplasmic reticulum chaperone GRP78 regulates macrophage function and insulin resistance in diet-induced obesity. FASEB J. 2018 04; 32(4):2292-2304. PMID: 29242277.
    Citations: 10     Fields:    Translation:AnimalsCells
  13. Abe Y, Nambu A, Yamaguchi S, Takamori A, Suto H, Hirose S, Yokosuka T, Nakae S, Sudo K. Role of interleukin-25 in development of spontaneous arthritis in interleukin-1 receptor antagonist-deficient mice. Biochem Biophys Rep. 2017 Dec; 12:62-65. PMID: 28955793.
  14. Hiraishi Y, Nambu A, Shibui A, Nakanishi W, Yamaguchi S, Morita H, Iikura M, McKenzie AN, Matsumoto K, Sudo K, Yamasoba T, Nagase T, Nakae S. TIM-3 is not essential for development of airway inflammation induced by house dust mite antigens. Allergol Int. 2016 Oct; 65(4):459-465. PMID: 27209052.
    Citations: 2     Fields:    Translation:AnimalsCells
  15. Shibui A, Takamori A, Tolba MEM, Nambu A, Shimura E, Yamaguchi S, Sanjoba C, Suto H, Sudo K, Okumura K, Sugano S, Morita H, Saito H, Matsumoto K, Nakae S. IL-25, IL-33 and TSLP receptor are not critical for development of experimental murine malaria. Biochem Biophys Rep. 2016 Mar; 5:191-195. PMID: 28955823.
    Citations: 5     
  16. Morita H, Arae K, Unno H, Miyauchi K, Toyama S, Nambu A, Oboki K, Ohno T, Motomura K, Matsuda A, Yamaguchi S, Narushima S, Kajiwara N, Iikura M, Suto H, McKenzie AN, Takahashi T, Karasuyama H, Okumura K, Azuma M, Moro K, Akdis CA, Galli SJ, Koyasu S, Kubo M, Sudo K, Saito H, Matsumoto K, Nakae S. An Interleukin-33-Mast Cell-Interleukin-2 Axis Suppresses Papain-Induced Allergic Inflammation by Promoting Regulatory T Cell Numbers. Immunity. 2015 Jul 21; 43(1):175-86. PMID: 26200013.
    Citations: 87     Fields:    Translation:HumansAnimalsCells
  17. Kim J, Ishiguro K, Nambu A, Akiyoshi B, Yokobayashi S, Kagami A, Ishiguro T, Pendas AM, Takeda N, Sakakibara Y, Kitajima TS, Tanno Y, Sakuno T, Watanabe Y. Meikin is a conserved regulator of meiosis-I-specific kinetochore function. Nature. 2015 Jan 22; 517(7535):466-71. PMID: 25533956.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  18. Shimura E, Shibui A, Narushima S, Nambu A, Yamaguchi S, Akitsu A, Leonard WJ, Iwakura Y, Matsumoto K, Suto H, Okumura K, Sudo K, Nakae S. Potential role of myeloid cell/eosinophil-derived IL-17 in LPS-induced endotoxin shock. Biochem Biophys Res Commun. 2014 Oct 10; 453(1):1-6. PMID: 25204502.
    Citations: 7     Fields:    Translation:AnimalsCells
  19. Nakanishi W, Yamaguchi S, Matsuda A, Suzukawa M, Shibui A, Nambu A, Kondo K, Suto H, Saito H, Matsumoto K, Yamasoba T, Nakae S. IL-33, but not IL-25, is crucial for the development of house dust mite antigen-induced allergic rhinitis. PLoS One. 2013; 8(10):e78099. PMID: 24205109.
    Citations: 22     Fields:    Translation:Animals
  20. Suzukawa M, Morita H, Nambu A, Arae K, Shimura E, Shibui A, Yamaguchi S, Suzukawa K, Nakanishi W, Oboki K, Kajiwara N, Ohno T, Ishii A, Körner H, Cua DJ, Suto H, Yoshimoto T, Iwakura Y, Yamasoba T, Ohta K, Sudo K, Saito H, Okumura K, Broide DH, Matsumoto K, Nakae S. Epithelial cell-derived IL-25, but not Th17 cell-derived IL-17 or IL-17F, is crucial for murine asthma. J Immunol. 2012 Oct 01; 189(7):3641-52. PMID: 22942422.
    Citations: 36     Fields:    Translation:AnimalsCells
  21. Shibui A, Shimura E, Nambu A, Yamaguchi S, Leonard WJ, Okumura K, Sugano S, Sudo K, Nakae S. Th17 cell-derived IL-17 is dispensable for B cell antibody production. Cytokine. 2012 Jul; 59(1):108-14. PMID: 22503615.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  22. Itoh S, Kimura N, Axtell RC, Velotta JB, Gong Y, Wang X, Kajiwara N, Nambu A, Shimura E, Adachi H, Iwakura Y, Saito H, Okumura K, Sudo K, Steinman L, Robbins RC, Nakae S, Fischbein MP. Interleukin-17 accelerates allograft rejection by suppressing regulatory T cell expansion. Circulation. 2011 Sep 13; 124(11 Suppl):S187-96. PMID: 21911812.
    Citations: 32     Fields:    Translation:AnimalsCells
  23. Shibui A, Nambu A, Shimura E, Yamaguchi S, Shiraishi C, Sato Y, Okumura K, Sugano S, Hozumi N, Nakae S. Alteration of immune responses by N-acetylglucosaminyltransferase V during allergic airway inflammation. Allergol Int. 2011 Sep; 60(3):345-54. PMID: 21502802.
    Citations:    Fields:    Translation:AnimalsCells
  24. Oboki K, Ohno T, Kajiwara N, Arae K, Morita H, Ishii A, Nambu A, Abe T, Kiyonari H, Matsumoto K, Sudo K, Okumura K, Saito H, Nakae S. IL-33 is a crucial amplifier of innate rather than acquired immunity. Proc Natl Acad Sci U S A. 2010 Oct 26; 107(43):18581-6. PMID: 20937871.
    Citations: 241     Fields:    Translation:Animals
  25. Ishii A, Oboki K, Nambu A, Morita H, Ohno T, Kajiwara N, Arae K, Sudo H, Okumura K, Saito H, Nakae S. Development of IL-17-mediated delayed-type hypersensitivity is not affected by down-regulation of IL-25 expression. Allergol Int. 2010 Dec; 59(4):399-408. PMID: 20864797.
    Citations: 14     Fields:    Translation:AnimalsCellsPHPublic Health
  26. Nambu A, Nakae S. IL-1 and Allergy. Allergol Int. 2010 Jun; 59(2):125-35. PMID: 20414049.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  27. Ishigame H, Kakuta S, Nagai T, Kadoki M, Nambu A, Komiyama Y, Fujikado N, Tanahashi Y, Akitsu A, Kotaki H, Sudo K, Nakae S, Sasakawa C, Iwakura Y. Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses. Immunity. 2009 Jan 16; 30(1):108-19. PMID: 19144317.
    Citations: 405     Fields:    Translation:AnimalsCells
  28. Zhao Z, Satsu H, Fujisawa M, Hori M, Ishimoto Y, Totsuka M, Nambu A, Kakuta S, Ozaki H, Shimizu M. Attenuation by dietary taurine of dextran sulfate sodium-induced colitis in mice and of THP-1-induced damage to intestinal Caco-2 cell monolayers. Amino Acids. 2008 Jun; 35(1):217-24. PMID: 17619120.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  29. Komiyama Y, Nakae S, Matsuki T, Nambu A, Ishigame H, Kakuta S, Sudo K, Iwakura Y. IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis. J Immunol. 2006 Jul 01; 177(1):566-73. PMID: 16785554.
    Citations: 620     Fields:    Translation:AnimalsCells
  30. Nambu A, Nakae S, Iwakura Y. IL-1beta, but not IL-1alpha, is required for antigen-specific T cell activation and the induction of local inflammation in the delayed-type hypersensitivity responses. Int Immunol. 2006 May; 18(5):701-12. PMID: 16569679.
    Citations: 24     Fields:    Translation:AnimalsCells
  31. Horai R, Nakajima A, Habiro K, Kotani M, Nakae S, Matsuki T, Nambu A, Saijo S, Kotaki H, Sudo K, Okahara A, Tanioka H, Ikuse T, Ishii N, Schwartzberg PL, Abe R, Iwakura Y. TNF-alpha is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice. J Clin Invest. 2004 Dec; 114(11):1603-11. PMID: 15578092.
    Citations: 39     Fields:    Translation:AnimalsCells
  32. Kagiwada K, Chida D, Sakatani T, Asano M, Nambu A, Kakuta S, Iwakura Y. Interleukin (IL)-6, but not IL-1, induction in the brain downstream of cyclooxygenase-2 is essential for the induction of febrile response against peripheral IL-1alpha. Endocrinology. 2004 Nov; 145(11):5044-8. PMID: 15271886.
    Citations: 8     Fields:    Translation:AnimalsCells
  33. Nakae S, Nambu A, Sudo K, Iwakura Y. Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice. J Immunol. 2003 Dec 01; 171(11):6173-7. PMID: 14634133.
    Citations: 486     Fields:    Translation:AnimalsCells
  34. Asano M, Nakae S, Kotani N, Shirafuji N, Nambu A, Hashimoto N, Kawashima H, Hirose M, Miyasaka M, Takasaki S, Iwakura Y. Impaired selectin-ligand biosynthesis and reduced inflammatory responses in beta-1,4-galactosyltransferase-I-deficient mice. Blood. 2003 Sep 01; 102(5):1678-85. PMID: 12714507.
    Citations: 45     Fields:    Translation:AnimalsCells
  35. Nakae S, Komiyama Y, Yokoyama H, Nambu A, Umeda M, Iwase M, Homma I, Sudo K, Horai R, Asano M, Iwakura Y. IL-1 is required for allergen-specific Th2 cell activation and the development of airway hypersensitivity response. Int Immunol. 2003 Apr; 15(4):483-90. PMID: 12663678.
    Citations: 47     Fields:    Translation:AnimalsCells
  36. Nakae S, Komiyama Y, Nambu A, Sudo K, Iwase M, Homma I, Sekikawa K, Asano M, Iwakura Y. Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses. Immunity. 2002 Sep; 17(3):375-87. PMID: 12354389.
    Citations: 384     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.