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Kun-Hsing Yu, Ph.D., M.D.

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Biography
Stanford University, Stanford, CAPh.D.09/2016Biomedical Informatics
Stanford University, Stanford, CAPh.D. Minor09/2016Computer Science
National Taiwan University, Taipei, TaiwanM.D.06/2011Medicine
2018 - 2019
Schlager Family Award for Early Stage Digital Health Innovations
2017 - 2019
Harvard Data Science Fellowship
2017 - 2017
Pacific Symposium on Biocomputing (PSB) Rigorous Secondary Data Analysis Award
2015 - 2016
Howard Hughes Medical Institute (HHMI) Fellowship
2012 - 2016
Winston Chen Stanford Graduate Fellow
2011 - 2011
Undergraduate Research Award, National Taiwan University College of Medicine
2010 - 2011
Best Intern Award, National Taiwan University Hospital

Overview
Kun-Hsing "Kun" Yu received his PhD in Biomedical Informatics and PhD Minor in Computer Science from Stanford University, and he obtained his MD from National Taiwan University, Taiwan. His research focuses on the integration of quantitative histopathology image patterns with multi-omics (genomics, epigenomics, transcriptomics, and proteomics) profiles to advance cancer research and clinical practice. His team has developed fully-automated algorithms to analyze whole-slide histopathology images at scale, discovered the molecular mechanisms underpinning the microscopic phenotypes of tumor cells, and identified novel cellular morphologies for patient prognosis. His research interests include quantitative pathology, machine learning, and translational bioinformatics.

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Marostica E, Barber R, Denize T, Kohane IS, Signoretti S, Golden JA, Yu KH. Development of a Histopathology Informatics Pipeline for Classification and Prediction of Clinical Outcomes in Subtypes of Renal Cell Carcinoma. Clin Cancer Res. 2021 Mar 15. PMID: 33722896.
    Citations:    Fields:    
  2. Kalinich M, Murphy W, Wongvibulsin S, Pahalyants V, Yu KH, Lu C, Wang F, Zubiri L, Naranbhai V, Gusev A, Kwatra SG, Reynolds KL, Semenov YR. Prediction of severe immune-related adverse events requiring hospital admission in patients on immune checkpoint inhibitors: study of a population level insurance claims database from the USA. J Immunother Cancer. 2021 Mar; 9(3). PMID: 33789879.
    Citations:    Fields:    
  3. Yuan W, Beaulieu-Jones BK, Yu KH, Lipnick SL, Palmer N, Loscalzo J, Cai T, Kohane IS. Temporal bias in case-control design: preventing reliable predictions of the future. Nat Commun. 2021 02 17; 12(1):1107. PMID: 33597541.
    Citations:    Fields:    Translation:Humans
  4. Marostica E, Yu KH. Deep decision support for lymph node metastatic risk evaluation. EBioMedicine. 2020 Dec; 62:103105. PMID: 33160208.
    Citations:    Fields:    
  5. Miron O, Delgado RE, Delgado CF, Simpson EA, Yu KH, Gutierrez A, Zeng G, Gerstenberger JN, Kohane IS. Prolonged Auditory Brainstem Response in Universal Hearing Screening of Newborns with Autism Spectrum Disorder. Autism Res. 2021 01; 14(1):46-52. PMID: 33140578.
    Citations: 1     Fields:    
  6. Yu KH, Hu V, Wang F, Matulonis UA, Mutter GL, Golden JA, Kohane IS. Deciphering serous ovarian carcinoma histopathology and platinum response by convolutional neural networks. BMC Med. 2020 08 18; 18(1):236. PMID: 32807164.
    Citations: 1     Fields:    Translation:Humans
  7. Yu KH, Lee TM, Yen MH, Kou SC, Rosen B, Chiang JH, Kohane IS. Reproducible Machine Learning Methods for Lung Cancer Detection Using Computed Tomography Images: Algorithm Development and Validation. J Med Internet Res. 2020 08 05; 22(8):e16709. PMID: 32755895.
    Citations: 1     Fields:    Translation:Humans
  8. Yu KH, Wang F, Berry GJ, Ré C, Altman RB, Snyder M, Kohane IS. Classifying non-small cell lung cancer types and transcriptomic subtypes using convolutional neural networks. J Am Med Inform Assoc. 2020 05 01; 27(5):757-769. PMID: 32364237.
    Citations: 6     Fields:    Translation:HumansCells
  9. Sánchez Fernández I, Yang E, Calvachi P, Amengual-Gual M, Wu JY, Krueger D, Northrup H, Bebin ME, Sahin M, Yu KH, Peters JM. Deep learning in rare disease. Detection of tubers in tuberous sclerosis complex. PLoS One. 2020; 15(4):e0232376. PMID: 32348367.
    Citations:    Fields:    Translation:Humans
  10. Beaulieu-Jones BK, Finlayson SG, Yuan W, Altman RB, Kohane IS, Prasad V, Yu KH. Examining the Use of Real-World Evidence in the Regulatory Process. Clin Pharmacol Ther. 2020 04; 107(4):843-852. PMID: 31562770.
    Citations: 2     Fields:    Translation:Humans
  11. Yang S, Yu KH, Palmer N, Fox K, Kou SC, Kohane IS. Autoimmune Effects of Lung Cancer Immunotherapy Revealed by Data-Driven Analysis on a Nationwide Cohort. Clin Pharmacol Ther. 2020 02; 107(2):388-396. PMID: 31356677.
    Citations: 2     Fields:    Translation:Humans
  12. Miron O, Yu KH, Wilf-Miron R, Kohane IS. Suicide Rates Among Adolescents and Young Adults in the United States, 2000-2017. JAMA. 2019 06 18; 321(23):2362-2364. PMID: 31211337.
    Citations: 22     Fields:    Translation:Humans
  13. Yu KH. Evaluation of Taroni et al.: Understanding Rare Diseases by MultiPLIER. Cell Syst. 2019 05 22; 8(5):359-360. PMID: 31121113.
    Citations:    Fields:    Translation:HumansCells
  14. Yuan W, Yu KH, Palmer N, Stanford FC, Kohane I. Evaluation of the association of bariatric surgery with subsequent depression. Int J Obes (Lond). 2019 12; 43(12):2528-2535. PMID: 31040396.
    Citations: 1     Fields:    Translation:Humans
  15. Yu KH, Miron O, Palmer N, Lemos DR, Fox K, Kou SC, Sahin M, Kohane IS. Data-driven analyses revealed the comorbidity landscape of tuberous sclerosis complex. Neurology. 2018 11 20; 91(21):974-976. PMID: 30333165.
    Citations: 1     Fields:    Translation:Humans
  16. Yu KH, Beam AL, Kohane IS. Artificial intelligence in healthcare. Nat Biomed Eng. 2018 10; 2(10):719-731. PMID: 31015651.
    Citations: 98     Fields:    Translation:Humans
  17. Yu KH, Beam AL, Kohane IS. Artificial intelligence in healthcare. Nat Biomed Eng. 2018; 2:719-731. View Publication.
  18. Yu KH, Kohane IS. Framing the challenges of artificial intelligence in medicine. BMJ Qual Saf. 2019 03; 28(3):238-241. PMID: 30291179.
    Citations: 17     Fields:    Translation:Humans
  19. Yu KH, Lee TM, Chen YJ, Ré C, Kou SC, Chiang JH, Snyder M, Kohane IS. A Cloud-Based Metabolite and Chemical Prioritization System for the Biology/Disease-Driven Human Proteome Project. J Proteome Res. 2018 12 07; 17(12):4345-4357. PMID: 30094994.
    Citations: 2     Fields:    Translation:Humans
  20. Pietrzak B, Ward A, Cheung MK, Schwendimann BA, Mollaoglu G, Duong MT, Ulltveit-Moe N, Allareddy V, Dutton-Regester K, Zhang J, Scult MA, Naz S, Singh PC, Yan HY, Isaacson K, Dennis AF, Al-Humaidan EI, Beardsley FR, Lo C, Sood P, Jones T, Nieuwenhuis R, Ali BA, Yu KH, Arthur PK, Kumar B, Chen A, Buschke F, Cingl L, Zaidi SS, O'Mullane AP, Coetzee V, Konstantinides N. Education for the future. Science. 2018 06 29; 360(6396):1409-1412. PMID: 29954971.
    Citations: 2     Fields:    
  21. Yu KH, Lee TM, Wang CS, Chen YJ, Ré C, Kou SC, Chiang JH, Kohane IS, Snyder M. Systematic Protein Prioritization for Targeted Proteomics Studies through Literature Mining. J Proteome Res. 2018 04 06; 17(4):1383-1396. PMID: 29505266.
    Citations: 4     Fields:    Translation:HumansAnimals
  22. Yu KH, Fitzpatrick MR, Pappas L, Chan W, Kung J, Snyder M. Omics AnalySIs System for PRecision Oncology (OASISPRO): a web-based omics analysis tool for clinical phenotype prediction. Bioinformatics. 2018 Jan 15; 34(2):319-320. PMID: 28968749.
    Citations: 4     Fields:    
  23. Yu KH, Berry GJ, Rubin DL, Ré C, Altman RB, Snyder M. Association of Omics Features with Histopathology Patterns in Lung Adenocarcinoma. Cell Syst. 2017 12 27; 5(6):620-627.e3. PMID: 29153840.
    Citations: 20     Fields:    Translation:HumansCells
  24. Segal L, Chow RD, Kumar B, Nguyen J, Yu KH, Chen J, Polat EO, Porter KE, Kelly-Irving M, Bimpe I, Winter KA, Zeng R, Ahmed M, Saalman DR, James JI, Kosinski M, White ER, Oda FS, Bretscher H, Hamel P, Negi S, Jawaid A. Promoting human rights through science. Science. 2017 10 06; 358(6359):34-37. PMID: 28983033.
    Citations: 2     Fields:    
  25. Musib M, Wang F, Tarselli MA, Yoho R, Yu KH, Andrés RM, Greenwald NF, Pan X, Lee CH, Zhang J, Dutton-Regester K, Johnston JW, Sharafeldin IM. Artificial intelligence in research. Science. 2017 Jul 07; 357(6346):28-30. PMID: 28684488.
    Citations: 4     Fields:    
  26. Roberts K, Boland MR, Pruinelli L, Dcruz J, Berry A, Georgsson M, Hazen R, Sarmiento RF, Backonja U, Yu KH, Jiang Y, Brennan PF. Biomedical informatics advancing the national health agenda: the AMIA 2015 year-in-review in clinical and consumer informatics. J Am Med Inform Assoc. 2017 Apr 01; 24(e1):e185-e190. PMID: 27497798.
    Citations: 5     Fields:    Translation:Humans
  27. Yu KH, Hart SN, Goldfeder R, Zhang QC, Parker SCJ, Snyder M. HARNESSING BIG DATA FOR PRECISION MEDICINE: INFRASTRUCTURES AND APPLICATIONS. Pac Symp Biocomput. 2017; 22:635-639. PMID: 27897013.
    Citations:    Fields:    Translation:Humans
  28. Yu KH. A survival guide for interdisciplinary PhD students. Nat Biotechnol. 2016 09 08; 34(9):993-4. PMID: 27606461.
    Citations:    Fields:    
  29. Matsa E, Burridge PW, Yu KH, Ahrens JH, Termglinchan V, Wu H, Liu C, Shukla P, Sayed N, Churko JM, Shao N, Woo NA, Chao AS, Gold JD, Karakikes I, Snyder MP, Wu JC. Transcriptome Profiling of Patient-Specific Human iPSC-Cardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro. Cell Stem Cell. 2016 09 01; 19(3):311-25. PMID: 27545504.
    Citations: 35     Fields:    Translation:HumansCells
  30. Yu KH, Zhang C, Berry GJ, Altman RB, Ré C, Rubin DL, Snyder M. Predicting non-small cell lung cancer prognosis by fully automated microscopic pathology image features. Nat Commun. 2016 08 16; 7:12474. PMID: 27527408.
    Citations: 151     Fields:    Translation:Humans
  31. Yu KH, Levine DA, Zhang H, Chan DW, Zhang Z, Snyder M. Predicting Ovarian Cancer Patients' Clinical Response to Platinum-Based Chemotherapy by Their Tumor Proteomic Signatures. J Proteome Res. 2016 08 05; 15(8):2455-65. PMID: 27312948.
    Citations: 9     Fields:    Translation:Humans
  32. Zhang H, Liu T, Zhang Z, Payne SH, Zhang B, McDermott JE, Zhou JY, Petyuk VA, Chen L, Ray D, Sun S, Yang F, Chen L, Wang J, Shah P, Cha SW, Aiyetan P, Woo S, Tian Y, Gritsenko MA, Clauss TR, Choi C, Monroe ME, Thomas S, Nie S, Wu C, Moore RJ, Yu KH, Tabb DL, Fenyö D, Bafna V, Wang Y, Rodriguez H, Boja ES, Hiltke T, Rivers RC, Sokoll L, Zhu H, Shih IM, Cope L, Pandey A, Zhang B, Snyder MP, Levine DA, Smith RD, Chan DW, Rodland KD. Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer. Cell. 2016 Jul 28; 166(3):755-765. PMID: 27372738.
    Citations: 236     Fields:    Translation:HumansCells
  33. Yu KH, Li J, Snyder M, Shaw GM, O'Brodovich HM. The genetic predisposition to bronchopulmonary dysplasia. Curr Opin Pediatr. 2016 06; 28(3):318-23. PMID: 26963946.
    Citations: 7     Fields:    Translation:Humans
  34. Yu KH, Snyder M. Omics Profiling in Precision Oncology. Mol Cell Proteomics. 2016 08; 15(8):2525-36. PMID: 27099341.
    Citations: 20     Fields:    Translation:Humans
  35. Li J, Yu KH, Oehlert J, Jeliffe-Pawlowski LL, Gould JB, Stevenson DK, Snyder M, Shaw GM, O'Brodovich HM. Exome Sequencing of Neonatal Blood Spots and the Identification of Genes Implicated in Bronchopulmonary Dysplasia. Am J Respir Crit Care Med. 2015 Sep 01; 192(5):589-96. PMID: 26030808.
    Citations: 21     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  36. Ho MJ, Yu KH, Pan H, Norris JL, Liang YS, Li JN, Hirsh D. A tale of two cities: understanding the differences in medical professionalism between two Chinese cultural contexts. Acad Med. 2014 Jun; 89(6):944-50. PMID: 24871248.
    Citations: 8     Fields:    Translation:Humans
  37. Chiang SC, Han CL, Yu KH, Chen YJ, Wu KP. Prioritization of cancer marker candidates based on the immunohistochemistry staining images deposited in the human protein atlas. PLoS One. 2013; 8(11):e81079. PMID: 24303032.
    Citations: 3     Fields:    Translation:Humans
  38. Ho MJ, Yu KH, Hirsh D, Huang TS, Yang PC. Does one size fit all? Building a framework for medical professionalism. Acad Med. 2011 Nov; 86(11):1407-14. PMID: 21971298.
    Citations: 21     Fields:    Translation:Humans
  39. Han CL, Chen JS, Chan EC, Wu CP, Yu KH, Chen KT, Tsou CC, Tsai CF, Chien CW, Kuo YB, Lin PY, Yu JS, Hsueh C, Chen MC, Chan CC, Chang YS, Chen YJ. An informatics-assisted label-free approach for personalized tissue membrane proteomics: case study on colorectal cancer. Mol Cell Proteomics. 2011 Apr; 10(4):M110.003087. PMID: 21209152.
    Citations: 16     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.