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Kun-Hsing Yu, M.D.,Ph.D.

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Biography
Stanford University, Stanford, CAPh.D.09/2016Biomedical Informatics
Stanford University, Stanford, CAPh.D. Minor09/2016Computer Science
National Taiwan University, Taipei, TaiwanM.D.06/2011Medicine
2018 - 2019
Schlager Family Award for Early Stage Digital Health Innovations
2017 - 2019
Harvard Data Science Fellowship
2017 - 2017
Pacific Symposium on Biocomputing (PSB) Rigorous Secondary Data Analysis Award
2016 - 2016
American Thoracic Society (ATS) Student Scholar
2015 - 2016
Howard Hughes Medical Institute (HHMI) International Student Research Fellow
2012 - 2016
Winston Chen Stanford Graduate Fellow
2011 - 2011
Undergraduate Research Award, National Taiwan University College of Medicine
2010 - 2011
Best Intern Award, National Taiwan University Hospital

Overview
Kun-Hsing Yu received his PhD in Biomedical Informatics and PhD Minor in Computer Science from Stanford University under the supervision of Professors Michael Snyder and Russ B. Altman. His doctoral research integrated lung cancer patients' omics (genomics, epigenomics, transcriptomics, and proteomics) profiles with quantitative histopathology patterns to predict their clinical phenotypes. He developed a fully-automated algorithm to extract thousands of features from whole-slide histopathology images, discovered the molecular mechanisms underpinning the microscopic phenotypes of tumor cells, and successfully identified previously unknown cellular morphologies associated with patient prognosis. Prior to joining Stanford, he obtained his MD from National Taiwan University and designed a bioinformatics framework to identify protein markers of colorectal cancer in Academia Sinica. Yu's current research interests include translational bioinformatics, machine learning, integrative studies on omics and medical images, biomarker discovery for complex diseases, and precision medicine.

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Yu KH, Miron O, Palmer N, Lemos DR, Fox K, Kou SC, Sahin M, Kohane IS. Data-driven analyses revealed the comorbidity landscape of tuberous sclerosis complex. Neurology. 2018 Nov 20; 91(21):974-976. PMID: 30333165.
    Citations:    
  2. Yu KH, Beam AL, Kohane IS. Artificial intelligence in healthcare. Nat Biomed Eng. 2018; 2:719-731. View Publication.
  3. Yu KH, Kohane IS. Framing the challenges of artificial intelligence in medicine. BMJ Qual Saf. 2019 Mar; 28(3):238-241. PMID: 30291179.
    Citations:    Fields:    
  4. Yu KH, Lee TM, Chen YJ, Ré C, Kou SC, Chiang JH, Snyder M, Kohane IS. A Cloud-Based Metabolite and Chemical Prioritization System for the Biology/Disease-Driven Human Proteome Project. J Proteome Res. 2018 Aug 21. PMID: 30094994.
    Citations:    Fields:    
  5. Pietrzak B, Ward A, Cheung MK, Schwendimann BA, Mollaoglu G, Duong MT, Ulltveit-Moe N, Allareddy V, Dutton-Regester K, Zhang J, Scult MA, Naz S, Singh PC, Yan HY, Isaacson K, Dennis AF, Al-Humaidan EI, Beardsley FR, Lo C, Sood P, Jones T, Nieuwenhuis R, Ali BA, Yu KH, Arthur PK, Kumar B, Chen A, Buschke F, Cingl L, Zaidi SS, O'Mullane AP, Coetzee V, Konstantinides N. Education for the future. Science. 2018 06 29; 360(6396):1409-1412. PMID: 29954971.
    Citations:    Fields:    
  6. Yu KH, Lee TM, Wang CS, Chen YJ, Ré C, Kou SC, Chiang JH, Kohane IS, Snyder M. Systematic Protein Prioritization for Targeted Proteomics Studies through Literature Mining. J Proteome Res. 2018 04 06; 17(4):1383-1396. PMID: 29505266.
    Citations:    Fields:    
  7. Yu KH, Berry GJ, Rubin DL, Ré C, Altman RB, Snyder M. Association of Omics Features with Histopathology Patterns in Lung Adenocarcinoma. Cell Syst. 2017 Dec 27; 5(6):620-627.e3. PMID: 29153840.
    Citations: 2     Fields:    
  8. Segal L, Chow RD, Kumar B, Nguyen J, Yu KH, Chen J, Polat EO, Porter KE, Kelly-Irving M, Bimpe I, Winter KA, Zeng R, Ahmed M, Saalman DR, James JI, Kosinski M, White ER, Oda FS, Bretscher H, Hamel P, Negi S, Jawaid A. Promoting human rights through science. Science. 2017 10 06; 358(6359):34-37. PMID: 28983033.
    Citations: 2     Fields:    
  9. Yu KH, Fitzpatrick MR, Pappas L, Chan W, Kung J, Snyder M. Omics AnalySIs System for PRecision Oncology (OASISPRO): A Web-based Omics Analysis Tool for Clinical Phenotype Prediction. Bioinformatics. 2017 09 12. PMID: 28968749.
    Citations:    Fields:    
  10. Musib M, Wang F, Tarselli MA, Yoho R, Yu KH, Andrés RM, Greenwald NF, Pan X, Lee CH, Zhang J, Dutton-Regester K, Johnston JW, Sharafeldin IM. Artificial intelligence in research. Science. 2017 Jul 07; 357(6346):28-30. PMID: 28684488.
    Citations:    Fields:    
  11. Roberts K, Boland MR, Pruinelli L, Dcruz J, Berry A, Georgsson M, Hazen R, Sarmiento RF, Backonja U, Yu KH, Jiang Y, Brennan PF. Biomedical informatics advancing the national health agenda: the AMIA 2015 year-in-review in clinical and consumer informatics. J Am Med Inform Assoc. 2017 Apr 01; 24(e1):e185-e190. PMID: 27497798.
    Citations: 2     Fields:    Translation:Humans
  12. Yu KH, Hart SN, Goldfeder R, Zhang QC, Parker SCJ, Snyder M. HARNESSING BIG DATA FOR PRECISION MEDICINE: INFRASTRUCTURES AND APPLICATIONS. Pac Symp Biocomput. 2017; 22:635-639. PMID: 27897013.
    Citations:    Fields:    Translation:Humans
  13. Yu KH. A survival guide for interdisciplinary PhD students. Nat Biotechnol. 2016 09 08; 34(9):993-4. PMID: 27606461.
    Citations:    Fields:    
  14. Matsa E, Burridge PW, Yu KH, Ahrens JH, Termglinchan V, Wu H, Liu C, Shukla P, Sayed N, Churko JM, Shao N, Woo NA, Chao AS, Gold JD, Karakikes I, Snyder MP, Wu JC. Transcriptome Profiling of Patient-Specific Human iPSC-Cardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro. Cell Stem Cell. 2016 09 01; 19(3):311-25. PMID: 27545504.
    Citations: 10     Fields:    Translation:HumansCells
  15. Yu KH, Zhang C, Berry GJ, Altman RB, Ré C, Rubin DL, Snyder M. Predicting non-small cell lung cancer prognosis by fully automated microscopic pathology image features. Nat Commun. 2016 08 16; 7:12474. PMID: 27527408.
    Citations: 34     Fields:    Translation:Humans
  16. Yu KH, Levine DA, Zhang H, Chan DW, Zhang Z, Snyder M. Predicting Ovarian Cancer Patients' Clinical Response to Platinum-Based Chemotherapy by Their Tumor Proteomic Signatures. J Proteome Res. 2016 08 05; 15(8):2455-65. PMID: 27312948.
    Citations:    Fields:    Translation:Humans
  17. Zhang H, Liu T, Zhang Z, Payne SH, Zhang B, McDermott JE, Zhou JY, Petyuk VA, Chen L, Ray D, Sun S, Yang F, Chen L, Wang J, Shah P, Cha SW, Aiyetan P, Woo S, Tian Y, Gritsenko MA, Clauss TR, Choi C, Monroe ME, Thomas S, Nie S, Wu C, Moore RJ, Yu KH, Tabb DL, Fenyö D, Bafna V, Wang Y, Rodriguez H, Boja ES, Hiltke T, Rivers RC, Sokoll L, Zhu H, Shih IM, Cope L, Pandey A, Zhang B, Snyder MP, Levine DA, Smith RD, Chan DW, Rodland KD. Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer. Cell. 2016 Jul 28; 166(3):755-765. PMID: 27372738.
    Citations: 86     Fields:    Translation:HumansCells
  18. Yu KH, Li J, Snyder M, Shaw GM, O'Brodovich HM. The genetic predisposition to bronchopulmonary dysplasia. Curr Opin Pediatr. 2016 06; 28(3):318-23. PMID: 26963946.
    Citations: 6     Fields:    Translation:Humans
  19. Yu KH, Snyder M. Omics Profiling in Precision Oncology. Mol Cell Proteomics. 2016 08; 15(8):2525-36. PMID: 27099341; PMCID: PMC4974334.
    Citations: 10     Fields:    Translation:Humans
  20. Li J, Yu KH, Oehlert J, Jeliffe-Pawlowski LL, Gould JB, Stevenson DK, Snyder M, Shaw GM, O'Brodovich HM. Exome Sequencing of Neonatal Blood Spots and the Identification of Genes Implicated in Bronchopulmonary Dysplasia. Am J Respir Crit Care Med. 2015 Sep 01; 192(5):589-96. PMID: 26030808; PMCID: PMC4595691.
    Citations: 10     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  21. Ho MJ, Yu KH, Pan H, Norris JL, Liang YS, Li JN, Hirsh D. A tale of two cities: understanding the differences in medical professionalism between two Chinese cultural contexts. Acad Med. 2014 Jun; 89(6):944-50. PMID: 24871248.
    Citations: 5     Fields:    Translation:Humans
  22. Chiang SC, Han CL, Yu KH, Chen YJ, Wu KP. Prioritization of cancer marker candidates based on the immunohistochemistry staining images deposited in the human protein atlas. PLoS One. 2013; 8(11):e81079. PMID: 24303032; PMCID: PMC3841220.
    Citations: 3     Fields:    Translation:Humans
  23. Ho MJ, Yu KH, Hirsh D, Huang TS, Yang PC. Does one size fit all? Building a framework for medical professionalism. Acad Med. 2011 Nov; 86(11):1407-14. PMID: 21971298.
    Citations: 14     Fields:    Translation:Humans
  24. Han CL, Chen JS, Chan EC, Wu CP, Yu KH, Chen KT, Tsou CC, Tsai CF, Chien CW, Kuo YB, Lin PY, Yu JS, Hsueh C, Chen MC, Chan CC, Chang YS, Chen YJ. An informatics-assisted label-free approach for personalized tissue membrane proteomics: case study on colorectal cancer. Mol Cell Proteomics. 2011 Apr; 10(4):M110.003087. PMID: 21209152; PMCID: PMC3069341.
    Citations: 15     Fields:    Translation:HumansCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.