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Maria Martinez-Lage Alvarez, M.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Bale TA, Jordan JT, Rapalino O, Ramamurthy N, Jessop N, DeWitt JC, Nardi V, Alvarez MM, Frosch M, Batchelor TT, Louis DN, Iafrate AJ, Cahill DP, Lennerz JK. Financially effective test algorithm to identify an aggressive, EGFR-amplified variant of IDH-wildtype, lower-grade diffuse glioma. Neuro Oncol. 2019 May 06; 21(5):596-605. PMID: 30496526.
    Citations:    Fields:    
  2. El-Jawahri AR, Schaefer PW, El Khoury JB, Martinez-Lage M. Case 5-2018: A 63-Year-Old Man with Confusion after Stem-Cell Transplantation. N Engl J Med. 2018 Feb 15; 378(7):659-669. PMID: 29443669.
    Citations:    Fields:    Translation:HumansCells
  3. Talos DM, Jacobs LM, Gourmaud S, Coto CA, Sun H, Lim KC, Lucas TH, Davis KA, Martinez-Lage M, Jensen FE. Mechanistic target of rapamycin complex 1 and 2 in human temporal lobe epilepsy. Ann Neurol. 2018 02; 83(2):311-327. PMID: 29331082.
    Citations: 2     Fields:    Translation:HumansCells
  4. Juratli TA, Thiede C, Koerner MVA, Tummala SS, Daubner D, Shankar GM, Williams EA, Martinez-Lage M, Soucek S, Robel K, Penson T, Krause M, Appold S, Meinhardt M, Pinzer T, Miller JJ, Krex D, Ely HA, Silverman IM, Christiansen J, Schackert G, Wakimoto H, Kirsch M, Brastianos PK, Cahill DP. Intratumoral heterogeneity and TERT promoter mutations in progressive/higher-grade meningiomas. Oncotarget. 2017 Dec 12; 8(65):109228-109237. PMID: 29312603.
    Citations: 2     Fields:    
  5. Lee JYK, Cho SS, Zeh R, Pierce JT, Martinez-Lage M, Adappa ND, Palmer JN, Newman JG, Learned KO, White C, Kharlip J, Snyder P, Low PS, Singhal S, Grady MS. Folate receptor overexpression can be visualized in real time during pituitary adenoma endoscopic transsphenoidal surgery with near-infrared imaging. J Neurosurg. 2018 Aug; 129(2):390-403. PMID: 28841122.
    Citations: 3     Fields:    
  6. O'Rourke DM, Nasrallah MP, Desai A, Melenhorst JJ, Mansfield K, Morrissette JJD, Martinez-Lage M, Brem S, Maloney E, Shen A, Isaacs R, Mohan S, Plesa G, Lacey SF, Navenot JM, Zheng Z, Levine BL, Okada H, June CH, Brogdon JL, Maus MV. A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma. Sci Transl Med. 2017 07 19; 9(399). PMID: 28724573.
    Citations: 36     Fields:    Translation:HumansCTClinical Trials
  7. Nasrallah MP, Nasrallah IM, Prelack MS, Johnson MO, Lewis TB, Rubenstein M, Minturn JE, Desai A, Marcotte P, Santi M, Martinez-Lage M. 19-Year-Old Male with Headaches and a Possible Seizure. Brain Pathol. 2017 07; 27(4):557-558. PMID: 28585383.
    Citations:    Fields:    Translation:Humans
  8. Bakas S, Akbari H, Pisapia J, Martinez-Lage M, Rozycki M, Rathore S, Dahmane N, O'Rourke DM, Davatzikos C. In Vivo Detection of EGFRvIII in Glioblastoma via Perfusion Magnetic Resonance Imaging Signature Consistent with Deep Peritumoral Infiltration: The f-Index. Clin Cancer Res. 2017 Aug 15; 23(16):4724-4734. PMID: 28428190.
    Citations: 2     Fields:    Translation:Humans
  9. Lee JYK, Pierce JT, Thawani JP, Zeh R, Nie S, Martinez-Lage M, Singhal S. Near-infrared fluorescent image-guided surgery for intracranial meningioma. J Neurosurg. 2018 Feb; 128(2):380-390. PMID: 28387632.
    Citations: 3     Fields:    
  10. Lee JY, Thawani JP, Pierce J, Zeh R, Martinez-Lage M, Chanin M, Venegas O, Nims S, Learned K, Keating J, Singhal S. Intraoperative Near-Infrared Optical Imaging Can Localize Gadolinium-Enhancing Gliomas During Surgery. Neurosurgery. 2016 Dec; 79(6):856-871. PMID: 27741220.
    Citations: 6     Fields:    Translation:Humans
  11. Guttenberg KB, Mayson SE, Sawan C, Kharlip J, Lee JY, Martinez-Lage M, Loevner LA, Ewanichak J, Grady MS, Snyder PJ. Prevalence of clinically silent corticotroph macroadenomas. Clin Endocrinol (Oxf). 2016 Dec; 85(6):874-880. PMID: 27346850.
    Citations: 1     Fields:    Translation:Humans
  12. Akbari H, Macyszyn L, Da X, Bilello M, Wolf RL, Martinez-Lage M, Biros G, Alonso-Basanta M, O'Rourke DM, Davatzikos C. Imaging Surrogates of Infiltration Obtained Via Multiparametric Imaging Pattern Analysis Predict Subsequent Location of Recurrence of Glioblastoma. Neurosurgery. 2016 Apr; 78(4):572-80. PMID: 26813856.
    Citations: 10     Fields:    Translation:Humans
  13. Bilello M, Akbari H, Da X, Pisapia JM, Mohan S, Wolf RL, O'Rourke DM, Martinez-Lage M, Davatzikos C. Population-based MRI atlases of spatial distribution are specific to patient and tumor characteristics in glioblastoma. Neuroimage Clin. 2016; 12:34-40. PMID: 27358767.
    Citations: 3     Fields:    Translation:Humans
  14. Nayak NR, Richard CE, Martinez-Lage M, Smith H, Malhotra NR. Synovial-type giant cell tumors of the axial spine. J Neurosurg Sci. 2017 02; 61(1):106-109. PMID: 26868266.
    Citations:    Fields:    Translation:Humans
  15. Lee AM, Bai HX, Zou Y, Qiu D, Zhou J, Martinez-Lage Alvarez M, Zhang P, Tao Y, Tang X, Xiao B, Yang L. Safety and diagnostic value of brain biopsy in HIV patients: a case series and meta-analysis of 1209 patients. J Neurol Neurosurg Psychiatry. 2016 Jul; 87(7):722-33. PMID: 26758989.
    Citations: 2     Fields:    Translation:Humans
  16. Evans SM, Putt M, Yang XY, Lustig RA, Martinez-Lage M, Williams D, Desai A, Wolf R, Brem S, Koch CJ. Initial evidence that blood-borne microvesicles are biomarkers for recurrence and survival in newly diagnosed glioblastoma patients. J Neurooncol. 2016 Apr; 127(2):391-400. PMID: 26746692.
    Citations: 5     Fields:    Translation:HumansCells
  17. Wang S, Martinez-Lage M, Sakai Y, Chawla S, Kim SG, Alonso-Basanta M, Lustig RA, Brem S, Mohan S, Wolf RL, Desai A, Poptani H. Differentiating Tumor Progression from Pseudoprogression in Patients with Glioblastomas Using Diffusion Tensor Imaging and Dynamic Susceptibility Contrast MRI. AJNR Am J Neuroradiol. 2016 Jan; 37(1):28-36. PMID: 26450533.
    Citations: 18     Fields:    Translation:Humans
  18. Chen HI, Bohman LE, Emery L, Martinez-Lage M, Richardson AG, Davis KA, Pollard JR, Litt B, Gausas RE, Lucas TH. Lateral Transorbital Endoscopic Access to the Hippocampus, Amygdala, and Entorhinal Cortex: Initial Clinical Experience. ORL J Otorhinolaryngol Relat Spec. 2015; 77(6):321-32. PMID: 26418017.
    Citations: 1     Fields:    Translation:Humans
  19. Macyszyn L, Akbari H, Pisapia JM, Da X, Attiah M, Pigrish V, Bi Y, Pal S, Davuluri RV, Roccograndi L, Dahmane N, Martinez-Lage M, Biros G, Wolf RL, Bilello M, O'Rourke DM, Davatzikos C. Imaging patterns predict patient survival and molecular subtype in glioblastoma via machine learning techniques. Neuro Oncol. 2016 Mar; 18(3):417-25. PMID: 26188015.
    Citations: 21     Fields:    Translation:Humans
  20. Abdullah KG, Ramayya A, Thawani JP, Macyszyn L, Martinez-Lage M, O'Rourke DM, Brem S. Factors associated with increased survival after surgical resection of glioblastoma in octogenarians. PLoS One. 2015; 10(5):e0127202. PMID: 25978638.
    Citations: 1     Fields:    Translation:Humans
  21. Kovatch KJ, Purkey MT, Martinez-Lage M, Gausas RE, Loevner LA, Grady MS, O'Malley BW, Rassekh CH. Management of an expansile orbital mass: Plexiform neurofibroma decompression by orbitozygomatic approach. Laryngoscope. 2015 Nov; 125(11):2457-60. PMID: 25960281.
    Citations:    Fields:    Translation:Humans
  22. Walsh AM, Kapoor GS, Buonato JM, Mathew LK, Bi Y, Davuluri RV, Martinez-Lage M, Simon MC, O'Rourke DM, Lazzara MJ. Sprouty2 Drives Drug Resistance and Proliferation in Glioblastoma. Mol Cancer Res. 2015 Aug; 13(8):1227-37. PMID: 25934697.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  23. Koch CJ, Lustig RA, Yang XY, Jenkins WT, Wolf RL, Martinez-Lage M, Desai A, Williams D, Evans SM. Microvesicles as a Biomarker for Tumor Progression versus Treatment Effect in Radiation/Temozolomide-Treated Glioblastoma Patients. Transl Oncol. 2014 Dec; 7(6):752-8. PMID: 25500085.
    Citations: 5     
  24. Brastianos PK, Taylor-Weiner A, Manley PE, Jones RT, Dias-Santagata D, Thorner AR, Lawrence MS, Rodriguez FJ, Bernardo LA, Schubert L, Sunkavalli A, Shillingford N, Calicchio ML, Lidov HG, Taha H, Martinez-Lage M, Santi M, Storm PB, Lee JY, Palmer JN, Adappa ND, Scott RM, Dunn IF, Laws ER, Stewart C, Ligon KL, Hoang MP, Van Hummelen P, Hahn WC, Louis DN, Resnick AC, Kieran MW, Getz G, Santagata S. Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas. Nat Genet. 2014 Feb; 46(2):161-5. PMID: 24413733.
    Citations: 63     Fields:    Translation:HumansCells
  25. Khaji A, Zhang L, Kowey P, Martinez-Lage M, Kocovic D. Mega-epsilon waves on 12-lead ECG--just another case of arrhythmogenic right ventricular dysplasia/cardiomyopathy? J Electrocardiol. 2013 Nov-Dec; 46(6):524-7. PMID: 24016846.
    Citations: 2     Fields:    Translation:Humans
  26. Busch JI, Martinez-Lage M, Ashbridge E, Grossman M, Van Deerlin VM, Hu F, Lee VM, Trojanowski JQ, Chen-Plotkin AS. Expression of TMEM106B, the frontotemporal lobar degeneration-associated protein, in normal and diseased human brain. Acta Neuropathol Commun. 2013 Jul 11; 1:36. PMID: 24252750.
    Citations: 6     Fields:    Translation:HumansCells
  27. Abedalthagafi M, Phillips JJ, Kim GE, Mueller S, Haas-Kogen DA, Marshall RE, Croul SE, Santi MR, Cheng J, Zhou S, Sullivan LM, Martinez-Lage M, Judkins AR, Perry A. The alternative lengthening of telomere phenotype is significantly associated with loss of ATRX expression in high-grade pediatric and adult astrocytomas: a multi-institutional study of 214 astrocytomas. Mod Pathol. 2013 Nov; 26(11):1425-32. PMID: 23765250.
    Citations: 22     Fields:    Translation:HumansCells
  28. Phillips JJ, Aranda D, Ellison DW, Judkins AR, Croul SE, Brat DJ, Ligon KL, Horbinski C, Venneti S, Zadeh G, Santi M, Zhou S, Appin CL, Sioletic S, Sullivan LM, Martinez-Lage M, Robinson AE, Yong WH, Cloughesy T, Lai A, Phillips HS, Marshall R, Mueller S, Haas-Kogan DA, Molinaro AM, Perry A. PDGFRA amplification is common in pediatric and adult high-grade astrocytomas and identifies a poor prognostic group in IDH1 mutant glioblastoma. Brain Pathol. 2013 Sep; 23(5):565-73. PMID: 23438035.
    Citations: 21     Fields:    Translation:Humans
  29. Martinez-Lage M, Molina-Porcel L, Falcone D, McCluskey L, Lee VM, Van Deerlin VM, Trojanowski JQ. TDP-43 pathology in a case of hereditary spastic paraplegia with a NIPA1/SPG6 mutation. Acta Neuropathol. 2012 Aug; 124(2):285-91. PMID: 22302102.
    Citations: 5     Fields:    Translation:HumansCells
  30. Becker DA, Ingala EE, Martinez-Lage M, Price RS, Galetta SL. Dry Beriberi and Wernicke's encephalopathy following gastric lap band surgery. J Clin Neurosci. 2012 Jul; 19(7):1050-2. PMID: 22525460.
    Citations: 5     Fields:    Translation:Humans
  31. Jean S, Tanyi JL, Montone K, McGrath C, Lage-Alvarez MM, Chu CS. Papillary thyroid cancer arising in struma ovarii. J Obstet Gynaecol. 2012 Apr; 32(3):222-6. PMID: 22369392.
    Citations: 7     Fields:    Translation:Humans
  32. Martinez-Hernandez E, Horvath J, Shiloh-Malawsky Y, Sangha N, Martinez-Lage M, Dalmau J. Analysis of complement and plasma cells in the brain of patients with anti-NMDAR encephalitis. Neurology. 2011 Aug 09; 77(6):589-93. PMID: 21795662.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  33. Chen-Plotkin AS, Martinez-Lage M, Sleiman PM, Hu W, Greene R, Wood EM, Bing S, Grossman M, Schellenberg GD, Hatanpaa KJ, Weiner MF, White CL, Brooks WS, Halliday GM, Kril JJ, Gearing M, Beach TG, Graff-Radford NR, Dickson DW, Rademakers R, Boeve BF, Pickering-Brown SM, Snowden J, van Swieten JC, Heutink P, Seelaar H, Murrell JR, Ghetti B, Spina S, Grafman J, Kaye JA, Woltjer RL, Mesulam M, Bigio E, Lladó A, Miller BL, Alzualde A, Moreno F, Rohrer JD, Mackenzie IR, Feldman HH, Hamilton RL, Cruts M, Engelborghs S, De Deyn PP, Van Broeckhoven C, Bird TD, Cairns NJ, Goate A, Frosch MP, Riederer PF, Bogdanovic N, Lee VM, Trojanowski JQ, Van Deerlin VM. Genetic and clinical features of progranulin-associated frontotemporal lobar degeneration. Arch Neurol. 2011 Apr; 68(4):488-97. PMID: 21482928.
    Citations: 26     Fields:    Translation:Humans
  34. Johnson JO, Mandrioli J, Benatar M, Abramzon Y, Van Deerlin VM, Trojanowski JQ, Gibbs JR, Brunetti M, Gronka S, Wuu J, Ding J, McCluskey L, Martinez-Lage M, Falcone D, Hernandez DG, Arepalli S, Chong S, Schymick JC, Rothstein J, Landi F, Wang YD, Calvo A, Mora G, Sabatelli M, Monsurrò MR, Battistini S, Salvi F, Spataro R, Sola P, Borghero G, Galassi G, Scholz SW, Taylor JP, Restagno G, Chiò A, Traynor BJ. Exome sequencing reveals VCP mutations as a cause of familial ALS. Neuron. 2010 Dec 09; 68(5):857-64. PMID: 21145000.
    Citations: 364     Fields:    Translation:HumansCells
  35. Van Deerlin VM, Sleiman PM, Martinez-Lage M, Chen-Plotkin A, Wang LS, Graff-Radford NR, Dickson DW, Rademakers R, Boeve BF, Grossman M, Arnold SE, Mann DM, Pickering-Brown SM, Seelaar H, Heutink P, van Swieten JC, Murrell JR, Ghetti B, Spina S, Grafman J, Hodges J, Spillantini MG, Gilman S, Lieberman AP, Kaye JA, Woltjer RL, Bigio EH, Mesulam M, Al-Sarraj S, Troakes C, Rosenberg RN, White CL, Ferrer I, Lladó A, Neumann M, Kretzschmar HA, Hulette CM, Welsh-Bohmer KA, Miller BL, Alzualde A, Lopez de Munain A, McKee AC, Gearing M, Levey AI, Lah JJ, Hardy J, Rohrer JD, Lashley T, Mackenzie IR, Feldman HH, Hamilton RL, Dekosky ST, van der Zee J, Kumar-Singh S, Van Broeckhoven C, Mayeux R, Vonsattel JP, Troncoso JC, Kril JJ, Kwok JB, Halliday GM, Bird TD, Ince PG, Shaw PJ, Cairns NJ, Morris JC, McLean CA, DeCarli C, Ellis WG, Freeman SH, Frosch MP, Growdon JH, Perl DP, Sano M, Bennett DA, Schneider JA, Beach TG, Reiman EM, Woodruff BK, Cummings J, Vinters HV, Miller CA, Chui HC, Alafuzoff I, Hartikainen P, Seilhean D, Galasko D, Masliah E, Cotman CW, Tuñón MT, Martínez MC, Munoz DG, Carroll SL, Marson D, Riederer PF, Bogdanovic N, Schellenberg GD, Hakonarson H, Trojanowski JQ, Lee VM. Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nat Genet. 2010 Mar; 42(3):234-9. PMID: 20154673.
    Citations: 157     Fields:    Translation:HumansCells
  36. Chen-Plotkin AS, Xiao J, Geser F, Martinez-Lage M, Grossman M, Unger T, Wood EM, Van Deerlin VM, Trojanowski JQ, Lee VM. Brain progranulin expression in GRN-associated frontotemporal lobar degeneration. Acta Neuropathol. 2010 Jan; 119(1):111-22. PMID: 19649643.
    Citations: 25     Fields:    Translation:HumansCells
  37. Geser F, Martinez-Lage M, Kwong LK, Lee VM, Trojanowski JQ. Amyotrophic lateral sclerosis, frontotemporal dementia and beyond: the TDP-43 diseases. J Neurol. 2009 Aug; 256(8):1205-14. PMID: 19271105.
    Citations: 59     Fields:    Translation:Humans
  38. Geser F, Martinez-Lage M, Robinson J, Uryu K, Neumann M, Brandmeir NJ, Xie SX, Kwong LK, Elman L, McCluskey L, Clark CM, Malunda J, Miller BL, Zimmerman EA, Qian J, Van Deerlin V, Grossman M, Lee VM, Trojanowski JQ. Clinical and pathological continuum of multisystem TDP-43 proteinopathies. Arch Neurol. 2009 Feb; 66(2):180-9. PMID: 19204154.
    Citations: 84     Fields:    Translation:HumansCells
  39. McCluskey LF, Elman LB, Martinez-Lage M, Van Deerlin V, Yuan W, Clay D, Siderowf A, Trojanowski JQ. Amyotrophic lateral sclerosis-plus syndrome with TAR DNA-binding protein-43 pathology. Arch Neurol. 2009 Jan; 66(1):121-4. PMID: 19139310.
    Citations: 23     Fields:    Translation:HumansCells
  40. Geser F, Brandmeir NJ, Kwong LK, Martinez-Lage M, Elman L, McCluskey L, Xie SX, Lee VM, Trojanowski JQ. Evidence of multisystem disorder in whole-brain map of pathological TDP-43 in amyotrophic lateral sclerosis. Arch Neurol. 2008 May; 65(5):636-41. PMID: 18474740.
    Citations: 90     Fields:    Translation:HumansCells
  41. Van Deerlin VM, Leverenz JB, Bekris LM, Bird TD, Yuan W, Elman LB, Clay D, Wood EM, Chen-Plotkin AS, Martinez-Lage M, Steinbart E, McCluskey L, Grossman M, Neumann M, Wu IL, Yang WS, Kalb R, Galasko DR, Montine TJ, Trojanowski JQ, Lee VM, Schellenberg GD, Yu CE. TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis. Lancet Neurol. 2008 May; 7(5):409-16. PMID: 18396105.
    Citations: 222     Fields:    Translation:Humans
  42. Molina-Porcel L, Lladó A, Rey MJ, Molinuevo JL, Martinez-Lage M, Esteve FX, Ferrer I, Tolosa E, Blesa R. Clinical and pathological heterogeneity of neuronal intermediate filament inclusion disease. Arch Neurol. 2008 Feb; 65(2):272-5. PMID: 18268200.
    Citations: 7     Fields:    Translation:HumansCells
  43. Rojas-Garcia R, Martinez-Lage M, Gallardo E, de Luna N, Marti-Vilalta JL, Diaz-Manera J, Juarez C, Blesa R, Illa I. A novel antiganglioside specificity against terminal NeuNAc(alfa 2-3)Gal in acute bulbar palsy. J Neuroimmunol. 2006 Jul; 176(1-2):219-22. PMID: 16707165.
    Citations: 1     Fields:    Translation:Humans
  44. Cocho D, Belvís R, Martí-Fàbregas J, Bravo Y, Aleu A, Pagonabarraga J, Molina-Porcel L, Díaz-Manera J, San Roman L, Martínez-Lage M, Martínez A, Moreno M, Martí-Vilalta JL. Does thrombolysis benefit patients with lacunar syndrome? Eur Neurol. 2006; 55(2):70-3. PMID: 16534209.
    Citations: 10     Fields:    Translation:Humans
  45. Cocho D, Borrell M, Martí-Fàbregas J, Montaner J, Castellanos M, Bravo Y, Molina-Porcel L, Belvís R, Díaz-Manera JA, Martínez-Domeño A, Martínez-Lage M, Millán M, Fontcuberta J, Martí-Vilalta JL. Pretreatment hemostatic markers of symptomatic intracerebral hemorrhage in patients treated with tissue plasminogen activator. Stroke. 2006 Apr; 37(4):996-9. PMID: 16497981.
    Citations: 10     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.