Harvard Catalyst Profiles

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Aabida Saferali, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K01HL157613 (SAFERALI, AABIDA) Apr 1, 2021 - Mar 31, 2026
    Integrative 'Omics of Transcriptome Complexity in COPD
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Biggs CM, Cordeiro-Santanach A, Prykhozhij SV, Deveau AP, Lin Y, Del Bel KL, Orben F, Ragotte RJ, Saferali A, Mostafavi S, Dinh L, Dai D, Weinacht KG, Dobbs K, Ott de Bruin L, Sharma M, Tsai K, Priatel JJ, Schreiber RA, Rozmus J, Hosking MC, Shopsowitz KE, McKinnon ML, Vercauteren S, Seear M, Notarangelo LD, Lynn FC, Berman JN, Turvey SE. Human JAK1 gain of function causes dysregulated myelopoeisis and severe allergic inflammation. JCI Insight. 2022 12 22; 7(24). PMID: 36546480.
    Citations:    Fields:    Translation:HumansAnimalsCells
  2. Saferali A, Qiao D, Kim W, Raraigh K, Levy H, Diaz AA, Cutting GR, Cho MH, Hersh CP. CFTR variants are associated with chronic bronchitis in smokers. Eur Respir J. 2022 08; 60(2). PMID: 34996830; PMCID: PMC9840463.
    Citations:    Fields:    
  3. Gregory A, Xu Z, Pratte K, Lee S, Liu C, Chase R, Yun J, Saferali A, Hersh CP, Bowler R, Silverman E, Castaldi PJ, Boueiz A. Clustering-based COPD subtypes have distinct longitudinal outcomes and multi-omics biomarkers. BMJ Open Respir Res. 2022 08; 9(1). PMID: 35999035; PMCID: PMC9403129.
    Citations: 1     Translation:HumansCTClinical Trials
  4. Saferali A, Hersh CP. Genetic Determinants in Airways Obstructive Diseases: The Case of Asthma Chronic Obstructive Pulmonary Disease Overlap. Immunol Allergy Clin North Am. 2022 08; 42(3):559-573. PMID: 35965045.
    Citations:    Fields:    Translation:Humans
  5. Yun JH, Lee S, Srinivasa P, Morrow J, Chase R, Saferali A, Xu Z, Cho M, Castaldi P, Hersh CP. An interferon-inducible signature of airway disease from blood gene expression profiling. Eur Respir J. 2022 05; 59(5). PMID: 34649980; PMCID: PMC9245457.
    Citations:    Fields:    Translation:Humans
  6. Ghosh AJ, Hobbs BD, Yun JH, Saferali A, Moll M, Xu Z, Chase RP, Morrow J, Ziniti J, Sciurba F, Barwick L, Limper AH, Flaherty K, Criner G, Brown KK, Wise R, Martinez FJ, McGoldrick D, Cho MH, DeMeo DL, Silverman EK, Castaldi PJ, Hersh CP. Lung tissue shows divergent gene expression between chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. Respir Res. 2022 Apr 21; 23(1):97. PMID: 35449067; PMCID: PMC9026726.
    Citations:    Fields:    Translation:HumansCells
  7. Ghosh AJ, Hobbs BD, Moll M, Saferali A, Boueiz A, Yun JH, Sciurba F, Barwick L, Limper AH, Flaherty K, Criner G, Brown KK, Wise R, Martinez FJ, Lomas D, Castaldi PJ, Carey VJ, DeMeo DL, Cho MH, Silverman EK, Hersh CP. Alpha-1 Antitrypsin MZ Heterozygosity Is an Endotype of Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2022 02 01; 205(3):313-323. PMID: 34762809; PMCID: PMC8886988.
    Citations: 3     Fields:    Translation:Humans
  8. Moll M, Boueiz A, Ghosh AJ, Saferali A, Lee S, Xu Z, Yun JH, Hobbs BD, Hersh CP, Sin DD, Tal-Singer R, Silverman EK, Cho MH, Castaldi PJ. Development of a Blood-based Transcriptional Risk Score for Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2022 01 15; 205(2):161-170. PMID: 34739356; PMCID: PMC8787248.
    Citations: 2     Fields:    Translation:Humans
  9. Sun L, Liu Y, Liu X, Wang R, Gong J, Saferali A, Gao W, Ma A, Ma H, Turvey SE, Fung SY, Yang H. Nano-Enabled Reposition of Proton Pump Inhibitors for TLR Inhibition: Toward A New Targeted Nanotherapy for Acute Lung Injury. Adv Sci (Weinh). 2022 01; 9(3):e2104051. PMID: 34816630; PMCID: PMC8787384.
    Citations: 1     Fields:    Translation:HumansAnimals
  10. Fung SY, Lu HY, Sharma M, Sharma AA, Saferali A, Jia A, Abraham L, Klein T, Gold MR, Noterangelo LD, Overall CM, Turvey SE. MALT1-Dependent Cleavage of HOIL1 Modulates Canonical NF-?B Signaling and Inflammatory Responsiveness. Front Immunol. 2021; 12:749794. PMID: 34721419; PMCID: PMC8552041.
    Citations:    Fields:    Translation:HumansCells
  11. Ghosh AJ, Saferali A, Lee S, Chase R, Moll M, Morrow J, Yun J, Castaldi PJ, Hersh CP. Blood RNA sequencing shows overlapping gene expression across COPD phenotype domains. Thorax. 2022 02; 77(2):115-122. PMID: 34168019; PMCID: PMC8711128.
    Citations: 3     Fields:    Translation:Humans
  12. Saferali A, Yun JH, Lee S, Chase RP, Bowler RP, Castaldi PJ, Hersh CP. Transcriptomic Signature of Asthma-Chronic Obstructive Pulmonary Disease Overlap in Whole Blood. Am J Respir Cell Mol Biol. 2021 02; 64(2):268-271. PMID: 33522883; PMCID: PMC7874396.
    Citations: 1     Fields:    Translation:HumansCells
  13. Saferali A, Xu Z, Sheynkman GM, Hersh CP, Cho MH, Silverman EK, Laederach A, Vollmers C, Castaldi PJ. Characterization of a COPD-Associated NPNT Functional Splicing Genetic Variant in Human Lung Tissue via Long-Read Sequencing. medRxiv. 2020 Nov 03. PMID: 33173926.
  14. Saferali A, Tang AC, Strug LJ, Quon BS, Zlosnik J, Sandford AJ, Turvey SE. Immunomodulatory function of the cystic fibrosis modifier gene BPIFA1. PLoS One. 2020; 15(1):e0227067. PMID: 31931521.
    Citations: 5     Fields:    Translation:HumansCells
  15. Parker MM, Chase RP, Lamb A, Reyes A, Saferali A, Yun JH, Himes BE, Silverman EK, Hersh CP, Castaldi PJ. Correction to: RNA sequencing identifies novel non-coding RNA and exon-specific effects associated with cigarette smoking. BMC Med Genomics. 2019 11 18; 12(1):166. PMID: 31739789.
    Citations:    Fields:    
  16. Yun JH, Chase R, Parker MM, Saferali A, Castaldi PJ, Silverman EK, Hersh CP. Peripheral Blood Gene Expression Signatures of Eosinophilic Chronic Obstructive Pulmonary Disease. Am J Respir Cell Mol Biol. 2019 09; 61(3):398-401. PMID: 31469299; PMCID: PMC6839929.
    Citations: 2     Fields:    Translation:HumansCells
  17. Saferali A, Yun JH, Parker MM, Sakornsakolpat P, Chase RP, Lamb A, Hobbs BD, Boezen MH, Dai X, de Jong K, Beaty TH, Wei W, Zhou X, Silverman EK, Cho MH, Castaldi PJ, Hersh CP. Analysis of genetically driven alternative splicing identifies FBXO38 as a novel COPD susceptibility gene. PLoS Genet. 2019 07; 15(7):e1008229. PMID: 31269066.
    Citations: 9     Fields:    Translation:HumansCells
  18. Sandford AJ, Ha A, Ngan DA, Akhabir L, Saferali A, Fox N, Hirsch Allen AJ, Warby SC, van Eeden SF, Ayas NT. Adhesion molecule gene variants and plasma protein levels in patients with suspected obstructive sleep apnea. PLoS One. 2019; 14(1):e0210732. PMID: 30653588; PMCID: PMC6336279.
    Citations: 5     Fields:    Translation:Humans
  19. Seo M, Qiu W, Bailey W, Criner GJ, Dransfield MT, Fuhlbrigge AL, Reilly JJ, Scholand MB, Castaldi P, Chase R, Parker M, Saferali A, Yun JH, Crapo JD, Cho MH, Beaty TH, Silverman EK, Hersh CP. Genomics and response to long-term oxygen therapy in chronic obstructive pulmonary disease. J Mol Med (Berl). 2018 12; 96(12):1375-1385. PMID: 30353303; PMCID: PMC6240374.
    Citations: 5     Fields:    Translation:Humans
  20. Yun JH, Lamb A, Chase R, Singh D, Parker MM, Saferali A, Vestbo J, Tal-Singer R, Castaldi PJ, Silverman EK, Hersh CP. Blood eosinophil count thresholds and exacerbations in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol. 2018 06; 141(6):2037-2047.e10. PMID: 29709670.
    Citations: 58     Fields:    Translation:HumansCells
  21. Parker MM, Chase RP, Lamb A, Reyes A, Saferali A, Yun JH, Himes BE, Silverman EK, Hersh CP, Castaldi PJ. RNA sequencing identifies novel non-coding RNA and exon-specific effects associated with cigarette smoking. BMC Med Genomics. 2017 10 06; 10(1):58. PMID: 28985737.
    Citations: 32     Fields:    Translation:Humans
  22. Del Bel KL, Ragotte RJ, Saferali A, Lee S, Vercauteren SM, Mostafavi SA, Schreiber RA, Prendiville JS, Phang MS, Halparin J, Au N, Dean JM, Priatel JJ, Jewels E, Junker AK, Rogers PC, Seear M, McKinnon ML, Turvey SE. JAK1 gain-of-function causes an autosomal dominant immune dysregulatory and hypereosinophilic syndrome. J Allergy Clin Immunol. 2017 06; 139(6):2016-2020.e5. PMID: 28111307.
    Citations: 33     Fields:    Translation:Humans
  23. Tang AC, Saferali A, He G, Sandford AJ, Strug LJ, Turvey SE. Endoplasmic Reticulum Stress and Chemokine Production in Cystic Fibrosis Airway Cells: Regulation by STAT3 Modulation. J Infect Dis. 2017 01 15; 215(2):293-302. PMID: 27799352.
    Citations: 12     Fields:    Translation:HumansCells
  24. Yang H, Kozicky L, Saferali A, Fung SY, Afacan N, Cai B, Falsafi R, Gill E, Liu M, Kollmann TR, Hancock RE, Sly LM, Turvey SE. Endosomal pH modulation by peptide-gold nanoparticle hybrids enables potent anti-inflammatory activity in phagocytic immune cells. Biomaterials. 2016 12; 111:90-102. PMID: 27728817.
    Citations: 17     Fields:    Translation:HumansCells
  25. Saferali A, Obeidat M, Bérubé JC, Lamontagne M, Bossé Y, Laviolette M, Hao K, Nickle DC, Timens W, Sin DD, Postma DS, Strug LJ, Gallins PJ, Paré PD, Bingle CD, Sandford AJ. Polymorphisms associated with expression of BPIFA1/BPIFB1 and lung disease severity in cystic fibrosis. Am J Respir Cell Mol Biol. 2015 Nov; 53(5):607-14. PMID: 25574903.
    Citations: 13     Fields:    Translation:HumansCells
  26. Martinez ME, Charalambous M, Saferali A, Fiering S, Naumova AK, St Germain D, Ferguson-Smith AC, Hernandez A. Genomic imprinting variations in the mouse type 3 deiodinase gene between tissues and brain regions. Mol Endocrinol. 2014 Nov; 28(11):1875-86. PMID: 25232934; PMCID: PMC4213365.
    Citations: 14     Fields:    Translation:AnimalsCells
  27. Saferali A, Lee J, Sin DD, Rouhani FN, Brantly ML, Sandford AJ. Longer telomere length in COPD patients with a1-antitrypsin deficiency independent of lung function. PLoS One. 2014; 9(4):e95600. PMID: 24763308.
    Citations: 17     Fields:    Translation:HumansCells
  28. Aminuddin F, Hackett TL, Stefanowicz D, Saferali A, Paré PD, Gulsvik A, Bakke P, Cho MH, Litonjua A, Lomas DA, Anderson WH, Beaty TH, Silverman EK, Sandford AJ. Nitric oxide synthase polymorphisms, gene expression and lung function in chronic obstructive pulmonary disease. BMC Pulm Med. 2013 Nov 06; 13:64. PMID: 24192154; PMCID: PMC3827989.
    Citations: 2     Fields:    Translation:Humans
  29. Saferali A, Moussette S, Chan D, Trasler J, Chen T, Rozen R, Naumova AK. DNA methyltransferase 1 (Dnmt1) mutation affects Snrpn imprinting in the mouse male germ line. Genome. 2012 Sep; 55(9):673-82. PMID: 22967183.
    Citations: 2     Fields:    Translation:AnimalsCells
  30. Saferali A, Berlivet S, Schimenti J, Bartolomei MS, Taketo T, Naumova AK. Defective imprint resetting in carriers of Robertsonian translocation Rb (8.12). Mamm Genome. 2010 Aug; 21(7-8):377-87. PMID: 20577743.
    Citations: 6     Fields:    Translation:AnimalsCells
  31. Saferali A, Grundberg E, Berlivet S, Beauchemin H, Morcos L, Polychronakos C, Pastinen T, Graham J, McNeney B, Naumova AK. Cell culture-induced aberrant methylation of the imprinted IG DMR in human lymphoblastoid cell lines. Epigenetics. 2010 Jan 01; 5(1):50-60. PMID: 20026906.
    Citations: 19     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.