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Dario Lemos, Ph.D.

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Biography
University of British Columbia, Canada01/2015Tissue regeneration
Oregon Health and Science University, USPh.D.11/2008Molecular physiology
Biogen, US10/2016Tissue injury and regeneration
2004 - 2005
Fogarty International Scholarship
2001 - 2002
Undergraduate Student Research Scholarship
2019 - 2019
Department of Medicine Chair's Research Award

Overview
Biomedical researcher with expertise in mechanisms of tissue regeneration and adult tissue somatic stem cell biology

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK124301 (LEMOS, DARIO) Apr 9, 2020 - Mar 31, 2023
    NIH
    Inflammatory Signaling in Kidney Stromal Cells Driving Interstitial Fibrosis
    Role: Principal Investigator
  2. R21AG058159 (LEMOS, DARIO) Jul 1, 2018 - Mar 31, 2020
    NIH
    Detection of aging mechanisms of nephron degeneration using nanoscale pathology
    Role Description: The goal of this project is to test, in collaboration with the MIT Media Lab, the use of Expansion Microscopy for the early detection of aging-associated changes in the nephron microenvironment in relation to the adoption of a secretory senescent phenotype in epithelial cells of the proximal tubule
    Role: Principal Investigator
  3. (Dario R. Lemos) May 18, 2018 - Nov 29, 2019
    Astellas Pharma US
    Bioengineered tissues for kidney regeneration in acute and chronic kidney injury
    Role Description: The goal of these studies is to test a series of procedures for the establishment of a kidney regeneration protocol using progenitor cells derived from human pluripotent stem cells.
    Role: Principal Investigator
  4. (Fabio M. V. Rossi) Sep 1, 2012 - Sep 1, 2015
    Heart and Stroke Foundation of Canada
    Characterization and therapeutic potential of fibroadipogenic progenitors
    Role Description: The main goal was to study the interactions between adipocyte progenitors and inflammatory innate immune cells in the context of metabolic syndrome. Specifically, the aim to study how secretion of TGF? by anti-inflammatory macrophages could regulate adipose depot growth by stimulating the proliferation of progenitor cells, supporting hyperplasia over hypertrophy, and therefore exerting a beneficial effect. The results were published in the journals Nature Medicine and Stem Cells.
    Role: Co-Investigator (Co-author)
  5. (Dario Lemos) Jul 1, 2010 - Jul 1, 2011
    Canadian Institutes of Health Research
    Effect of Imatinib mesylate (Gleevec®) on sarcopenia-associated fibrofatty muscle degeneration
    Role Description: The goal of the study was to explore the effect of Gleevec treatment on aging-associated ectopic intramuscular connective tissue accumulation in mice. The results were published in the journal Stem Cell Research.
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Soliman H, Paylor B, Scott RW, Lemos DR, Chang C, Arostegui M, Low M, Lee C, Fiore D, Braghetta P, Pospichalova V, Barkauskas CE, Korinek V, Rampazzo A, MacLeod K, Underhill TM, Rossi FMV. Pathogenic Potential of Hic1-Expressing Cardiac Stromal Progenitors. Cell Stem Cell. 2020 Mar 05; 26(3):459-461. PMID: 32142665.
    Citations:    
  2. Soliman H, Paylor B, Scott RW, Lemos DR, Chang C, Arostegui M, Low M, Lee C, Fiore D, Braghetta P, Pospichalova V, Barkauskas CE, Korinek V, Rampazzo A, MacLeod K, Underhill TM, Rossi FMV. Pathogenic Potential of Hic1-Expressing Cardiac Stromal Progenitors. Cell Stem Cell. 2020 Feb 06; 26(2):205-220.e8. PMID: 31978365.
    Citations:    
  3. Sobral-Reyes MF, Lemos DR. Recapitulating human tissue damage, repair, and fibrosis with human pluripotent stem cell-derived organoids. Stem Cells. 2020 Mar; 38(3):318-329. PMID: 31778256.
    Citations:    
  4. Yu KH, Miron O, Palmer N, Lemos DR, Fox K, Kou SC, Sahin M, Kohane IS. Data-driven analyses revealed the comorbidity landscape of tuberous sclerosis complex. Neurology. 2018 11 20; 91(21):974-976. PMID: 30333165.
    Citations:    
  5. Lemos DR, McMurdo M, Karaca G, Wilflingseder J, Leaf IA, Gupta N, Miyoshi T, Susa K, Johnson BG, Soliman K, Wang G, Morizane R, Bonventre JV, Duffield JS. Interleukin-1ß Activates a MYC-Dependent Metabolic Switch in Kidney Stromal Cells Necessary for Progressive Tubulointerstitial Fibrosis. J Am Soc Nephrol. 2018 06; 29(6):1690-1705. PMID: 29739813.
    Citations:    Fields:    
  6. Lemos DR, Duffield JS. Tissue-resident mesenchymal stromal cells: Implications for tissue-specific antifibrotic therapies. Sci Transl Med. 2018 01 31; 10(426). PMID: 29386358.
    Citations: 2     Fields:    
  7. Fiore D, Judson RN, Low M, Lee S, Zhang E, Hopkins C, Xu P, Lenzi A, Rossi FM, Lemos DR. Pharmacological blockage of fibro/adipogenic progenitor expansion and suppression of regenerative fibrogenesis is associated with impaired skeletal muscle regeneration. Stem Cell Res. 2016 07; 17(1):161-9. PMID: 27376715.
    Citations: 7     Fields:    Translation:AnimalsCells
  8. Lemos DR, Marsh G, Huang A, Campanholle G, Aburatani T, Dang L, Gomez I, Fisher K, Ligresti G, Peti-Peterdi J, Duffield JS. Maintenance of vascular integrity by pericytes is essential for normal kidney function. Am J Physiol Renal Physiol. 2016 12 01; 311(6):F1230-F1242. PMID: 27335372.
    Citations: 7     Fields:    Translation:AnimalsCells
  9. Lemos DR, Eisner C, Hopkins CI, Rossi FMV. Skeletal muscle-resident MSCs and bone formation. Bone. 2015 Nov; 80:19-23. PMID: 26103092.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  10. Lemos DR, Babaeijandaghi F, Low M, Chang CK, Lee ST, Fiore D, Zhang RH, Natarajan A, Nedospasov SA, Rossi FM. Nilotinib reduces muscle fibrosis in chronic muscle injury by promoting TNF-mediated apoptosis of fibro/adipogenic progenitors. Nat Med. 2015 Jul; 21(7):786-94. PMID: 26053624.
    Citations: 60     Fields:    Translation:AnimalsCells
  11. Paylor B, Joe AW, Rossi FM, Lemos DR. In vivo characterization of neural crest-derived fibro/adipogenic progenitor cells as a likely cellular substrate for craniofacial fibrofatty infiltrating disorders. Biochem Biophys Res Commun. 2014 Aug 15; 451(1):148-51. PMID: 25073114.
    Citations: 2     Fields:    Translation:AnimalsCells
  12. Pretheeban T, Lemos DR, Paylor B, Zhang RH, Rossi FM. Role of stem/progenitor cells in reparative disorders. Fibrogenesis Tissue Repair. 2012 Dec 27; 5(1):20. PMID: 23270300.
    Citations: 10     
  13. Lemos DR, Paylor B, Chang C, Sampaio A, Underhill TM, Rossi FM. Functionally convergent white adipogenic progenitors of different lineages participate in a diffused system supporting tissue regeneration. Stem Cells. 2012 Jun; 30(6):1152-62. PMID: 22415977.
    Citations: 15     Fields:    Translation:AnimalsCells
  14. Natarajan A, Lemos DR, Rossi FM. Fibro/adipogenic progenitors: a double-edged sword in skeletal muscle regeneration. Cell Cycle. 2010 Jun 01; 9(11):2045-6. PMID: 20505371.
    Citations: 20     Fields:    Translation:AnimalsCells
  15. Urbanski HF, Noriega NC, Lemos DR, Kohama SG. Gene expression profiling in the rhesus macaque: experimental design considerations. Methods. 2009 Sep; 49(1):26-31. PMID: 19467336.
    Citations: 8     Fields:    Translation:Animals
  16. Lemos DR, Downs JL, Raitiere MN, Urbanski HF. Photoperiodic modulation of adrenal gland function in the rhesus macaque: effect on 24-h plasma cortisol and dehydroepiandrosterone sulfate rhythms and adrenal gland gene expression. J Endocrinol. 2009 May; 201(2):275-85. PMID: 19223397.
    Citations: 8     Fields:    Translation:Animals
  17. Sitzmann BD, Lemos DR, Ottinger MA, Urbanski HF. Effects of age on clock gene expression in the rhesus macaque pituitary gland. Neurobiol Aging. 2010 Apr; 31(4):696-705. PMID: 18614257.
    Citations: 12     Fields:    Translation:AnimalsCells
  18. Lemos DR, Goodspeed L, Tonelli L, Antoch MP, Ojeda SR, Urbanski HF. Evidence for circadian regulation of activating transcription factor 5 but not tyrosine hydroxylase by the chromaffin cell clock. Endocrinology. 2007 Dec; 148(12):5811-21. PMID: 17823250.
    Citations: 8     Fields:    Translation:AnimalsCells
  19. Carla Famá M, Raden D, Zacchi N, Lemos DR, Robinson AS, Silberstein S. The Saccharomyces cerevisiae YFR041C/ERJ5 gene encoding a type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum. Biochim Biophys Acta. 2007 Feb; 1773(2):232-42. PMID: 17157937.
    Citations:    
  20. Garyfallou VT, Lemos D, Urbanski HF. Expression profiling of genes encoding glutamate and GABA receptor subunits in three immortalized GnRH cell lines. Brain Res. 2006 May 01; 1086(1):50-4. PMID: 16626661.
    Citations: 4     Fields:    Translation:AnimalsCells
  21. Lemos DR, Downs JL, Urbanski HF. Twenty-four-hour rhythmic gene expression in the rhesus macaque adrenal gland. Mol Endocrinol. 2006 May; 20(5):1164-76. PMID: 16439464.
    Citations: 30     Fields:    Translation:AnimalsCells
  22. Airaldi MG, Alonso-Romanowski S, Ambrosio A, Bessone JB, Bibiloni AG, Castro EA, Cravero C, Debenedetti SL, De Filippo J, Denzoin LA, Fernández Lahore M, Fiamberti H, Fossati CA, Franchi AM, Furnari JC, Gadaleta P, Gaggioli N, García AP, Ghilarducci A, Gubertini MT, Hajos S, Hermida EB, Hozbor D, Ielpi L, Iriondo M, Isturiz MA, Jasnis MA, Kochen S, Landoni MF, Lemos DR, Manghi M, Milana JP, Nonzioli AC, Otero AM, Palermo M, Pérez O, Ravelo A, Rearte B, Recavarren MI, Rodríguez ME, Rofman A, Sadir AM, Sasiain MC, Schattner M, Stumpo R, Yantorno O. [Vaccine production in Argentina: a decision that cannot be postponed]. Medicina (B Aires). 2003; 63(5):457-8. PMID: 14628659.
    Citations:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.