Instructor in Ophthalmology
Massachusetts Eye and Ear Infirmary
Schepens Eye Research Institute
20 Staniford St
Boston MA 02114
|University of Connecticut, Storrs||PhD||2016||Chemistry|
|Amirkabir University, Tehran||MSc||2003||Chemistry|
|Tabriz University, Tabriz||BSc||2001||Chemistry|
Dr. Sina Sharifi is currently an NIH Pathway to Independence (K99/R00) Fellow. He received his Ph.D. in Chemistry from the University of Connecticut, focusing on the self-assembly of surfactants around single-walled carbon nanotubes (SWNTs), where he developed a new method to quantify and control surfactant-SWNTs interactions. Dr. Sharifi also holds an M.Sc. degree in Chemistry from Amirkabir University (Iran), centered on synthesizing fluoroquinolones in the aqueous media. His research led to the invention of optimized conditions for large-scale production of fluoroquinolones in the aqueous media. Before his Ph.D., Dr. Sharifi worked as a research instructor in a chemistry research institute in Iran on various organic chemistry projects while mentoring M.Sc. students.
As an interdisciplinary scientist, Dr. Sharifi aims to integrate chemistry, polymer and materials sciences, nanomaterials, biomaterials, and ophthalmology to engineer biodevices such as the artificial cornea and study their interaction with biological entities and their functionalities. Since joining HMS, he developed several approaches to enhance biocompatibility (through covalent surface functionalization or sputtering) and the shelf-life of current Boston-Keratoprosthesis (B-KPro) or corneal tissue (through gamma or electron-beam irradiation). Dr. Sharifi also designed a methodology to crosslink corneal tissues through a combination of ionizing irradiation and media’s polarity. Moreover, he engineered a gelatin-based biomaterial, which can function as a corneal filler, adhesive, or stand-alone corneal graft. He also developed a new strategy to in situ exfoliate graphite to graphene sheets and then covalently integrate them with hydrogel with the aim of generating a suturable artificial corneal scaffold. He is currently working on the development a cost-effective, suturable, biodegradable, synthetic artificial cornea that can be used as a corneal substitute in Penetrating Keratoplasty (PK), Deep Anterior Lamellar Keratoplasty (DALK), or as a carrier for B-KPro surgeries.
The research activities and funding listed below are automatically derived from
NIH ExPORTER and other sources, which might result in incorrect or missing items.
to make corrections and additions.
Apr 1, 2020 - Mar 31, 2022
Generation of suturable artificial cornea from the integration of exfoliated graphene with gelatin glycidyl methacrylate
Role: Principal Investigator
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