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Sina Sharifi, Ph.D.

Title
Institution
Department
Address

Biography
University of Connecticut, StorrsPhD2016Chemistry
Amirkabir University, TehranMSc2003Chemistry
Tabriz University, TabrizBSc2001Chemistry

Overview
Dr. Sina Sharifi is currently an NIH Pathway to Independence (K99/R00) Fellow. He received his Ph.D. in Chemistry from the University of Connecticut, focusing on the self-assembly of surfactants around single-walled carbon nanotubes (SWNTs), where he developed a new method to quantify and control surfactant-SWNTs interactions. Dr. Sharifi also holds an M.Sc. degree in Chemistry from Amirkabir University (Iran), centered on synthesizing fluoroquinolones in the aqueous media. His research led to the invention of optimized conditions for large-scale production of fluoroquinolones in the aqueous media. Before his Ph.D., Dr. Sharifi worked as a research instructor in a chemistry research institute in Iran on various organic chemistry projects while mentoring M.Sc. students.
As an interdisciplinary scientist, Dr. Sharifi aims to integrate chemistry, polymer and materials sciences, nanomaterials, biomaterials, and ophthalmology to engineer biodevices such as the artificial cornea and study their interaction with biological entities and their functionalities. Since joining HMS, he developed several approaches to enhance biocompatibility (through covalent surface functionalization or sputtering) and the shelf-life of current Boston-Keratoprosthesis (B-KPro) or corneal tissue (through gamma or electron-beam irradiation). Dr. Sharifi also designed a methodology to crosslink corneal tissues through a combination of ionizing irradiation and media’s polarity. Moreover, he engineered a gelatin-based biomaterial, which can function as a corneal filler, adhesive, or stand-alone corneal graft. He also developed a new strategy to in situ exfoliate graphite to graphene sheets and then covalently integrate them with hydrogel with the aim of generating a suturable artificial corneal scaffold. He is currently working on the development a cost-effective, suturable, biodegradable, synthetic artificial cornea that can be used as a corneal substitute in Penetrating Keratoplasty (PK), Deep Anterior Lamellar Keratoplasty (DALK), or as a carrier for B-KPro surgeries.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K99EY030553 (SHARIFI, SINA) Apr 1, 2020 - Mar 31, 2022
    NIH
    Generation of suturable artificial cornea from the integration of exfoliated graphene with gelatin glycidyl methacrylate
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Sharifi S, Sharifi H. Electrospun-Reinforced Suturable Biodegradable Artificial Cornea. ACS Appl Bio Mater. 2022 Dec 19; 5(12):5716-5727. PMID: 36416454.
    Citations:    Fields:    Translation:HumansCells
  2. Akbari A, Bigham A, Rahimkhoei V, Sharifi S, Jabbari E. Antiviral Polymers: A Review. Polymers (Basel). 2022 Apr 19; 14(9). PMID: 35566804; PMCID: PMC9101550.
    Citations:    
  3. Ali Aminkhani, Sina Sharifi. Solvent-Free Synthesis of Pyrrolo [2, 1-a] Isoquinolines via One-Pot Four-Component Reaction. Letters in Organic Chemistry. 2022; 19(3):244-249. View Publication.
  4. Ashkan Bigham, Vahid Rahimkhoei, Payam Abasian, Masoud Delfi, Jamal Naderi, Matineh Ghomi, Farnaz Dabbagh Moghaddam, Tayyab Waqar, Yavuz Nuri Ertas, Sina Sharifi, Navid Rabiee, Sezgin Ersoy, Aziz Maleki, Ehsan Nazarzadeh Zare, Esmaeel Sharifi, Esmaiel Jabbari, Pooyan Makvandi, Ali Akbari. Advances in tannic acid-incorporated biomaterials: Infection treatment, regenerative medicine, cancer therapy, and biosensing. Chemical Engineering Journal. 2021; 432:134146. View Publication.
  5. Mehdi Hassanpour, Hessam Jafari, Sina Sharifi, Jafar Rezaie, Zohreh Mehri Lighvan, Gholam Reza Mahdavinia, Gholamreza Gohari, Ali Akbari. Salicylic acid-loaded chitosan nanoparticles (SA/CTS NPs) for breast cancer targeting: Synthesis, characterization and controlled release kinetics. Journal of Molecular Structure. 2021; 1245:131040. View Publication.
  6. Sharifi S, Sharifi H, Akbari A, Chodosh J. Systematic optimization of visible light-induced crosslinking conditions of gelatin methacryloyl (GelMA). Sci Rep. 2021 12 02; 11(1):23276. PMID: 34857867; PMCID: PMC8640009.
    Citations: 2     Fields:    Translation:Cells
  7. Sharifi S, Sharifi H, Akbari A, Dohlman CH, Paschalis EI, Gonzalez-Andrades M, Kong J, Chodosh J. Graphene-Lined Porous Gelatin Glycidyl Methacrylate Hydrogels: Implications for Tissue Engineering. ACS Appl Nano Mater. 2021 Nov 26; 4(11):12650-12662. PMID: 35252778; PMCID: PMC8897984.
    Citations: 1     
  8. Sharifi S, Sharifi H, Akbari A, Lei F, Dohlman CH, Gonzalez-Andrades M, Guild C, Paschalis EI, Chodosh J. Critical media attributes in E-beam sterilization of corneal tissue. Acta Biomater. 2022 01 15; 138:218-227. PMID: 34755604; PMCID: PMC8738149.
    Citations:    Fields:    Translation:PHPublic Health
  9. Roholah Sharifi, Miguel Gonzalez Andrades, James Chodosh. Light activated adhesive scaffold. 2021. View Publication.
  10. Sharifi S, Sharifi H, Akbari A, Koza D, Dohlman CH, Paschalis EI, Chodosh J. Photo-cross-linked Gelatin Glycidyl Methacrylate/N-Vinylpyrrolidone Copolymeric Hydrogel with Tunable Mechanical Properties for Ocular Tissue Engineering Applications. ACS Appl Bio Mater. 2021 10 18; 4(10):7682-7691. PMID: 35006715; PMCID: PMC8855968.
    Citations: 3     Fields:    Translation:Humans
  11. Aminkhani A, Sharifi S, Hosseinzadeh P. Chemical Constituent, Antimicrobial Activity, and Synergistic Effect of the Stem, Leaf, and Flower Essential Oil of the Artemisia fragrans Willd. from Khoy. Chem Biodivers. 2021 Aug; 18(8):e2100241. PMID: 34081830.
    Citations:    Fields:    Translation:AnimalsCells
  12. Yuan A, Ma K, Sharifi S, Pineda R. Biomechanical Testing of Flanged Polypropylene Sutures in Scleral Fixation. Am J Ophthalmol. 2021 10; 230:134-142. PMID: 33945819.
    Citations:    Fields:    Translation:Humans
  13. Sharifi S, Islam MM, Sharifi H, Islam R, Koza D, Reyes-Ortega F, Alba-Molina D, Nilsson PH, Dohlman CH, Mollnes TE, Chodosh J, Gonzalez-Andrades M. Tuning gelatin-based hydrogel towards bioadhesive ocular tissue engineering applications. Bioact Mater. 2021 Nov; 6(11):3947-3961. PMID: 33937594.
    Citations: 12     
  14. Sharifi S, Sharifi H, Guild C, Islam MM, Tran KD, Patzer C, Dohlman CH, Paschalis EI, Gonzalez-Andrades M, Chodosh J. Toward electron-beam sterilization of a pre-assembled Boston keratoprosthesis. Ocul Surf. 2021 04; 20:176-184. PMID: 33667673; PMCID: PMC8113118.
    Citations: 4     Fields:    Translation:HumansPHPublic Health
  15. Sharifi S, Islam MM, Sharifi H, Islam R, Huq TN, Nilsson PH, Mollnes TE, Tran KD, Patzer C, Dohlman CH, Patra HK, Paschalis EI, Gonzalez-Andrades M, Chodosh J. Electron Beam Sterilization of Poly(Methyl Methacrylate)-Physicochemical and Biological Aspects. Macromol Biosci. 2021 04; 21(4):e2000379. PMID: 33624923.
    Citations: 5     Fields:    Translation:HumansCellsPHPublic Health
  16. Ma KK, Yuan A, Sharifi S, Pineda R. A Biomechanical Study of Flanged Intrascleral Haptic Fixation of Three-Piece Intraocular Lenses. Am J Ophthalmol. 2021 07; 227:45-52. PMID: 33626366.
    Citations: 1     Fields:    Translation:Humans
  17. Sina Sharifi, Hannah Sharifi, Darrell Koza, Ali Aminkhani. Disproportionation of aliphatic and aromatic aldehydes through Cannizzaro, Tishchenko, and Meerwein–Ponndorf–Verley reactions. Monatshefte für Chemie-Chemical Monthly. 2021; 152:803-808. View Publication.
  18. Sharifi S, Islam MM, Sharifi H, Islam R, Nilsson PH, Dohlman CH, Mollnes TE, Paschalis EI, Chodosh J. Sputter Deposition of Titanium on Poly(Methyl Methacrylate) Enhances Corneal Biocompatibility. Transl Vis Sci Technol. 2020 12; 9(13):41. PMID: 33442495.
    Citations: 7     Fields:    Translation:Humans
  19. Rahimkhoei V, Jabbari N, Nourani A, Sharifi S, Akbari A. Potential small-molecule drugs as available weapons to fight novel coronavirus (2019-nCoV): A review. Cell Biochem Funct. 2021 Jan; 39(1):4-9. PMID: 32803762; PMCID: PMC7461398.
    Citations: 6     Fields:    Translation:HumansCells
  20. Amir Nasajpour, Azadeh Mostafavi, Adrian Chlanda, Chiara Rinoldi, Sina Sharifi, Matthew S Ji, Matthew Ye, Steven J Jonas, Wojciech Swieszkowski, Paul S Weiss, Ali Khademhosseini, Ali Tamayol. Cholesteryl ester liquid crystal nanofibers for tissue engineering applications. ACS Materials Letters. 2020; 2(9):1067-1073. View Publication.
  21. Ali Aminkhani, Roholah Sharifi, Reza Dorosti. Chemical Composition and Antimicrobial Activity of Achillea tenuifolia Lam. Essential Oil at Different Phenological Stages from Khoy. Chemistry & Biodiversity. 2020; 16(12):e1900289. View Publication.
  22. Aminkhani A, Sharifi S, Ekhtiyari S. Achillea filipendulina Lam.: Chemical Constituents and Antimicrobial Activities of Essential Oil of Stem, Leaf, and Flower. Chem Biodivers. 2020 May; 17(5):e2000133. PMID: 32239617.
    Citations:    Fields:    Translation:AnimalsCells
  23. Roholah Sharifi, Soudabe Mahmoudzadeh, Mohammad Mirazul Islam, Darrell Koza, Claes H Dohlman, James Chodosh, Miguel Gonzalez-Andrades. Covalent Functionalization of PMMA Surface with L-3, 4-Dihydroxyphenylalanine (L-DOPA) to Enhance its Biocompatibility and Adhesion to Corneal Tissue. Advanced Materials Interfaces. 2020; 7(1):1900767. View Publication.
  24. Ali Aminkhani, Roholah Sharifi, Elaheh Ranjbar, Firouzeh Chalabian, Fatemeh Katouzian. Antimicrobial activities and chemical constituents of essential oil extracted from stem, leaf, and flower of Thymus fedtschenkoi from Khoy, Iran. Journal of Food Processing and Preservation. 2019; 43(10):e14149. View Publication.
  25. Islam MM, Sharifi R, Mamodaly S, Islam R, Nahra D, Abusamra DB, Hui PC, Adibnia Y, Goulamaly M, Paschalis EI, Cruzat A, Kong J, Nilsson PH, Argüeso P, Mollnes TE, Chodosh J, Dohlman CH, Gonzalez-Andrades M. Effects of gamma radiation sterilization on the structural and biological properties of decellularized corneal xenografts. Acta Biomater. 2019 09 15; 96:330-344. PMID: 31284096.
    Citations: 18     Fields:    Translation:HumansAnimalsPHPublic Health
  26. Ali Aminkhani, Mina Talati, Roholah Sharifi, Firouzeh Chalabian, Fatemeh Katouzian. Highly Efficient One-Pot Three-Component Synthesis and Antimicrobial Activity of 2-Amino-4H-chromene Derivatives. Journal of Heterocyclic Chemistry. 2019; 76:1812-1819. View Publication.
  27. Mohammad Mirazul Islam, Roholah Sharifi, and Miguel Gonzalez-Andrades. Corneal Regeneration: Therapy and Surgery. Corneal Tissue Engineering. 2019; 23-40. View Publication.
  28. Sharifi R, Yang Y, Adibnia Y, Dohlman CH, Chodosh J, Gonzalez-Andrades M. Finding an Optimal Corneal Xenograft Using Comparative Analysis of Corneal Matrix Proteins Across Species. Sci Rep. 2019 02 12; 9(1):1876. PMID: 30755666.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  29. Trujillo-de Santiago G, Sharifi R, Yue K, Sani ES, Kashaf SS, Alvarez MM, Leijten J, Khademhosseini A, Dana R, Annabi N. Ocular adhesives: Design, chemistry, crosslinking mechanisms, and applications. Biomaterials. 2019 03; 197:345-367. PMID: 30690421.
    Citations: 21     Fields:    Translation:HumansAnimals
  30. Gonzalez-Andrades M, Sharifi R, Islam MM, Divoux T, Haist M, Paschalis EI, Gelfand L, Mamodaly S, Di Cecilia L, Cruzat A, Ulm FJ, Chodosh J, Delori F, Dohlman CH. Improving the practicality and safety of artificial corneas: Pre-assembly and gamma-rays sterilization of the Boston Keratoprosthesis. Ocul Surf. 2018 07; 16(3):322-330. PMID: 29627599.
    Citations: 11     Fields:    Translation:HumansPHPublic Health
  31. Nasajpour A, Mandla S, Shree S, Mostafavi E, Sharifi R, Khalilpour A, Saghazadeh S, Hassan S, Mitchell MJ, Leijten J, Hou X, Moshaverinia A, Annabi N, Adelung R, Mishra YK, Shin SR, Tamayol A, Khademhosseini A. Nanostructured Fibrous Membranes with Rose Spike-Like Architecture. Nano Lett. 2017 10 11; 17(10):6235-6240. PMID: 28819978; PMCID: PMC5683165.
    Citations: 17     Fields:    Translation:HumansCells
  32. Leijten J, Seo J, Yue K, Santiago GT, Tamayol A, Ruiz-Esparza GU, Shin SR, Sharifi R, Noshadi I, Álvarez MM, Zhang YS, Khademhosseini A. Spatially and Temporally Controlled Hydrogels for Tissue Engineering. Mater Sci Eng R Rep. 2017 Sep; 119:1-35. PMID: 29200661; PMCID: PMC5708586.
    Citations: 50     
  33. Sharifi R, Samaraweera M, Gascón JA, Papadimitrakopoulos F. Thermodynamics of the quasi-epitaxial flavin assembly around various-chirality carbon nanotubes. J Am Chem Soc. 2014 May 21; 136(20):7452-63. PMID: 24821307.
    Citations: 4     Fields:    Translation:Cells
  34. R Sharifi, DC Abanulo, F Papadimitrakopoulos. Isotopically Induced Variation in the Stability of FMN-Wrapped Carbon Nanotubes. Langmuir. 2013; 29(24):7209-7215. View Publication.
  35. M Saeed Abaee, Elahe Akbarzadeh, Roholah Sharifi, Mohammad M Mojtahedi. Environmentally friendly transesterification and transacylation reactions under LiBr catalysis. Monatshefte für Chemie-Chemical Monthly. 2010; 141(7):757-761. View Publication.
  36. M Saeed Abaee, Mohammad M Mojtahedi, Soudabeh Forghani, Nafiseh M Ghandchi, Mehdi Forouzani, Roholah Sharifi, Behnam Chaharnazm. A green, inexpensive and efficient organocatalyzed procedure for aqueous aldol condensations. Journal of the Brazilian Chemical Society. 2009; 20:1895-1900. View Publication.
  37. MS Abaee, MM Mojtahedi, R Sharifi, AW Mesbah, W Massa. Lithium bromide mediated synthesis and X-Ray analysis of bisarylmethylidenes of piperidinone system. Chem Listy. 2008; 102:s956-s958.
  38. M Saeed Abaee, Mohammad M Mojtahedi, Roholah Sharifi, Mohammad M Zahedi, A Wahid Mesbah, Werner Massa. Synthesis and X-ray crystallographic analysis of a bis (arylmethylidene) pyranone structure. Journal of Chemical Research. 2008; 2008(7):388. View Publication.
  39. M Saeed Abaee, Mohammad M Mojtahedi, M Mehdi Zahedi, Roholah Sharifi, Hamidreza Khavasi. Efficient synthesis of novel 3-substituted thiopyran-4-ones. Synthesis. 2007; 21:3339-3344. View Publication.
  40. RM. Saeed Abaee,* Mohammad M. Mojtahedi, Roholah Sharifi, M. Mehdi Zahedi . A Highly Efficient Method for Solvent-Free Synthesis of Bis(arylmethylidene)piperidinones. J. Heterocyclic Chem. 2007; 44:1497.
  41. M Saeed Abaee, Mohammad M Mojtahedi, M Mehdi Zahedi, Roholah Sharifi, A Wahid Mesbah, Werner Massa. Synthesis and structural elucidation of novel bisarylmethylidenes of cyclic enones. Synthetic Communications . 2007; 37(17):2949-2957. View Publication.
  42. Mojtahedi MM, Akbarzadeh E, Sharifi R, Abaee MS. Lithium bromide as a flexible, mild, and recyclable reagent for solvent-free Cannizzaro, Tishchenko, and Meerwein-Ponndorf-Verley reactions. Org Lett. 2007 Jul 19; 9(15):2791-3. PMID: 17580879.
    Citations: 7     Fields:    
  43. M Saeed Abaee, Mohammad M Mojtahedi, M Mehdi Zahedi, Roholah Sharifi. A highly efficient method for solvent-free synthesis of bisarylmethylidenes of pyranones and thiopyranones. Heteroatom Chemistry. 2007; 18(1):44-49. View Publication.
  44. MS Abaee, MM Mojtahedi, R Sharifi, MM Zahedi, H Abbasi, K Tabar-Heida. Facile synthesis of bis (arylmethylidene) cycloalkanones mediated by lithium perchlorate under solvent-free conditions. Journal of the Iranian Chemical Society. 2006; 3(3):293-296. View Publication.
  45. Abaee MS, Sharifi R, Mojtahedi MM. Room-temperature Cannizzaro reaction under mild conditions facilitated by magnesium bromide ethyl etherate and triethylamine. Org Lett. 2005 Dec 22; 7(26):5893-5. PMID: 16354093.
    Citations: 1     Fields:    
  46. M Saeed Abaee, Roholah Sharifi, Shahin Borhani, Majid Heravi, Hossein Motahari. Convenient one pot synthesis of some fluoroquinolones in aqueous media. Convenient one pot synthesis of some fluoroquinolones in aqueous media. 2005; 11(5):415-418. View Publication.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.