Harvard Catalyst Profiles

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Onur Dagliyan, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Pastore F, Battistoni M, Sollazzo R, Renna P, Paciello F, Li Puma DD, Barone E, Dagliyan O, Ripoli C, Grassi C. A Bioengineering Strategy to Control ADAM10 Activity in Living Cells. Int J Mol Sci. 2023 Jan 04; 24(2). PMID: 36674432; PMCID: PMC9863580.
    Citations:    Fields:    Translation:HumansAnimals
  2. Renna P, Ripoli C, Dagliyan O, Pastore F, Rinaudo M, Re A, Paciello F, Grassi C. Engineering a switchable single-chain TEV protease to control protein maturation in living neurons. Bioeng Transl Med. 2022 May; 7(2):e10292. PMID: 35600650; PMCID: PMC9115699.
    Citations: 3     
  3. Cakir B, Tanaka Y, Kiral FR, Xiang Y, Dagliyan O, Wang J, Lee M, Greaney AM, Yang WS, duBoulay C, Kural MH, Patterson B, Zhong M, Kim J, Bai Y, Min W, Niklason LE, Patra P, Park IH. Expression of the transcription factor PU.1 induces the generation of microglia-like cells in human cortical organoids. Nat Commun. 2022 01 20; 13(1):430. PMID: 35058453; PMCID: PMC8776770.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  4. Liu B, Stone OJ, Pablo M, Herron JC, Nogueira AT, Dagliyan O, Grimm JB, Lavis LD, Elston TC, Hahn KM. Biosensors based on peptide exposure show single molecule conformations in live cells. Cell. 2021 10 28; 184(22):5670-5685.e23. PMID: 34637702; PMCID: PMC8556369.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  5. Yap EL, Pettit NL, Davis CP, Nagy MA, Harmin DA, Golden E, Dagliyan O, Lin C, Rudolph S, Sharma N, Griffith EC, Harvey CD, Greenberg ME. Bidirectional perisomatic inhibitory plasticity of a Fos neuronal network. Nature. 2021 02; 590(7844):115-121. PMID: 33299180; PMCID: PMC7864877.
    Citations: 16     Fields:    Translation:AnimalsCells
  6. Wu HD, Kikuchi M, Dagliyan O, Aragaki AK, Nakamura H, Dokholyan NV, Umehara T, Inoue T. Rational design and implementation of a chemically inducible heterotrimerization system. Nat Methods. 2020 09; 17(9):928-936. PMID: 32747768; PMCID: PMC9936427.
    Citations: 8     Fields:    Translation:HumansCells
  7. Ozkan-Dagliyan I, Diehl JN, George SD, Schaefer A, Papke B, Klotz-Noack K, Waters AM, Goodwin CM, Gautam P, Pierobon M, Peng S, Gilbert TSK, Lin KH, Dagliyan O, Wennerberg K, Petricoin EF, Tran NL, Bhagwat SV, Tiu RV, Peng SB, Herring LE, Graves LM, Sers C, Wood KC, Cox AD, Der CJ. Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers. Cell Rep. 2020 06 16; 31(11):107764. PMID: 32553168.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  8. Dagliyan O, Dokholyan NV, Hahn KM. Engineering proteins for allosteric control by light or ligands. Nat Protoc. 2019 06; 14(6):1863-1883. PMID: 31076662.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  9. Dagliyan O, Hahn KM. Controlling protein conformation with light. Curr Opin Struct Biol. 2019 08; 57:17-22. PMID: 30849716; PMCID: PMC6697613.
    Citations: 9     Fields:    Translation:Cells
  10. Dagliyan O, Krokhotin A, Ozkan-Dagliyan I, Deiters A, Der CJ, Hahn KM, Dokholyan NV. Computational design of chemogenetic and optogenetic split proteins. Nat Commun. 2018 10 02; 9(1):4042. PMID: 30279442.
    Citations: 38     Fields:    
  11. Ma X, Dagliyan O, Hahn KM, Danuser G. Profiling cellular morphodynamics by spatiotemporal spectrum decomposition. PLoS Comput Biol. 2018 08; 14(8):e1006321. PMID: 30071020; PMCID: PMC6091976.
    Citations: 17     Fields:    Translation:AnimalsCells
  12. Dagliyan O, Karginov AV, Yagishita S, Gale ME, Wang H, DerMardirossian C, Wells CM, Dokholyan NV, Kasai H, Hahn KM. Engineering Pak1 Allosteric Switches. ACS Synth Biol. 2017 07 21; 6(7):1257-1262. PMID: 28365983.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  13. Dagliyan O, Tarnawski M, Chu PH, Shirvanyants D, Schlichting I, Dokholyan NV, Hahn KM. Engineering extrinsic disorder to control protein activity in living cells. Science. 2016 12 16; 354(6318):1441-1444. PMID: 27980211.
    Citations: 85     Fields:    Translation:HumansCells
  14. Hodgson L, Spiering D, Sabouri-Ghomi M, Dagliyan O, DerMardirossian C, Danuser G, Hahn KM. FRET binding antenna reports spatiotemporal dynamics of GDI-Cdc42 GTPase interactions. Nat Chem Biol. 2016 10; 12(10):802-809. PMID: 27501396; PMCID: PMC5030135.
    Citations: 23     Fields:    Translation:HumansCells
  15. Shobair M, Dagliyan O, Kota P, Dang YL, He H, Stutts MJ, Dokholyan NV. Gain-of-Function Mutation W493R in the Epithelial Sodium Channel Allosterically Reconfigures Intersubunit Coupling. J Biol Chem. 2016 Feb 19; 291(8):3682-92. PMID: 26668308.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  16. Chu PH, Tsygankov D, Berginski ME, Dagliyan O, Gomez SM, Elston TC, Karginov AV, Hahn KM. Engineered kinase activation reveals unique morphodynamic phenotypes and associated trafficking for Src family isoforms. Proc Natl Acad Sci U S A. 2014 Aug 26; 111(34):12420-5. PMID: 25118278.
    Citations: 29     Fields:    Translation:AnimalsCells
  17. Furukawa Y, Teraguchi S, Ikegami T, Dagliyan O, Jin L, Hall D, Dokholyan NV, Namba K, Akira S, Kurosaki T, Baba Y, Standley DM. Intrinsic disorder mediates cooperative signal transduction in STIM1. J Mol Biol. 2014 May 15; 426(10):2082-97. PMID: 24650897.
    Citations: 10     Fields:    Translation:AnimalsCells
  18. Redler RL, Shirvanyants D, Dagliyan O, Ding F, Kim DN, Kota P, Proctor EA, Ramachandran S, Tandon A, Dokholyan NV. Computational approaches to understanding protein aggregation in neurodegeneration. J Mol Cell Biol. 2014 Apr; 6(2):104-15. PMID: 24620031.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  19. Freeman TC, Black JL, Bray HG, Dagliyan O, Wu YI, Tripathy A, Dokholyan NV, Leisner TM, Parise LV. Identification of novel integrin binding partners for calcium and integrin binding protein 1 (CIB1): structural and thermodynamic basis of CIB1 promiscuity. Biochemistry. 2013 Oct 08; 52(40):7082-90. PMID: 24011356.
    Citations: 12     Fields:    Translation:Cells
  20. Kummer L, Hsu CW, Dagliyan O, MacNevin C, Kaufholz M, Zimmermann B, Dokholyan NV, Hahn KM, Plückthun A. Knowledge-based design of a biosensor to quantify localized ERK activation in living cells. Chem Biol. 2013 Jun 20; 20(6):847-56. PMID: 23790495.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  21. Dagliyan O, Shirvanyants D, Karginov AV, Ding F, Fee L, Chandrasekaran SN, Freisinger CM, Smolen GA, Huttenlocher A, Hahn KM, Dokholyan NV. Rational design of a ligand-controlled protein conformational switch. Proc Natl Acad Sci U S A. 2013 Apr 23; 110(17):6800-4. PMID: 23569285.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  22. Çakir B, Dagliyan O, Dagyildiz E, Baris I, Kavakli IH, Kizilel S, Türkay M. Structure based discovery of small molecules to regulate the activity of human insulin degrading enzyme. PLoS One. 2012; 7(2):e31787. PMID: 22355395.
    Citations: 9     Fields:    Translation:HumansCells
  23. Dagliyan O, Proctor EA, D'Auria KM, Ding F, Dokholyan NV. Structural and dynamic determinants of protein-peptide recognition. Structure. 2011 Dec 07; 19(12):1837-45. PMID: 22153506.
    Citations: 39     Fields:    Translation:Cells
  24. Dagliyan O, Uney-Yuksektepe F, Kavakli IH, Turkay M. Optimization based tumor classification from microarray gene expression data. PLoS One. 2011 Feb 04; 6(2):e14579. PMID: 21326602.
    Citations: 19     Fields:    Translation:Humans
  25. Dagliyan O, Kavakli IH, Turkay M. Classification of cytochrome P450 inhibitors with respect to binding free energy and pIC50 using common molecular descriptors. J Chem Inf Model. 2009 Oct; 49(10):2403-11. PMID: 19777996.
    Citations: 6     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.