Harvard Catalyst Profiles

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Vladimir Seplyarskiy, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Seplyarskiy VB, Sunyaev S. Author Correction: The origin of human mutation in light of genomic data. Nat Rev Genet. 2021 Oct; 22(10):687. PMID: 34376821.
    Citations:    Fields:    
  2. Seplyarskiy VB, Soldatov RA, Koch E, McGinty RJ, Goldmann JM, Hernandez RD, Barnes K, Correa A, Burchard EG, Ellinor PT, McGarvey ST, Mitchell BD, Vasan RS, Redline S, Silverman E, Weiss ST, Arnett DK, Blangero J, Boerwinkle E, He J, Montgomery C, Rao DC, Rotter JI, Taylor KD, Brody JA, Chen YI, de Las Fuentes L, Hwu CM, Rich SS, Manichaikul AW, Mychaleckyj JC, Palmer ND, Smith JA, Kardia SLR, Peyser PA, Bielak LF, O'Connor TD, Emery LS, Gilissen C, Wong WSW, Kharchenko PV, Sunyaev S. Population sequencing data reveal a compendium of mutational processes in the human germ line. Science. 2021 08 27; 373(6558):1030-1035. PMID: 34385354; PMCID: PMC9217108.
    Citations: 10     Fields:    Translation:HumansCells
  3. Goldmann JM, Seplyarskiy VB, Wong WSW, Vilboux T, Neerincx PB, Bodian DL, Solomon BD, Veltman JA, Deeken JF, Gilissen C, Niederhuber JE. Publisher Correction: Germline de novo mutation clusters arise during oocyte aging in genomic regions with high double-strand-break incidence. Nat Genet. 2021 Aug; 53(8):1270. PMID: 34302146.
    Citations:    Fields:    
  4. Seplyarskiy VB, Sunyaev S. The origin of human mutation in light of genomic data. Nat Rev Genet. 2021 10; 22(10):672-686. PMID: 34163020.
    Citations: 5     Fields:    Translation:HumansCells
  5. Seplyarskiy VB, Akkuratov EE, Akkuratova N, Andrianova MA, Nikolaev SI, Bazykin GA, Adameyko I, Sunyaev SR. Error-prone bypass of DNA lesions during lagging-strand replication is a common source of germline and cancer mutations. Nat Genet. 2019 01; 51(1):36-41. PMID: 30510240; PMCID: PMC6317876.
    Citations: 14     Fields:    Translation:HumansCells
  6. Goldmann JM, Seplyarskiy VB, Wong WSW, Vilboux T, Neerincx PB, Bodian DL, Solomon BD, Veltman JA, Deeken JF, Gilissen C, Niederhuber JE. Germline de novo mutation clusters arise during oocyte aging in genomic regions with high double-strand-break incidence. Nat Genet. 2018 04; 50(4):487-492. PMID: 29507425.
    Citations: 28     Fields:    Translation:HumansCells
  7. Andrianova MA, Chetan GK, Sibin MK, Mckee T, Merkler D, Narasinga RK, Ribaux P, Blouin JL, Makrythanasis P, Seplyarskiy VB, Antonarakis SE, Nikolaev SI. Germline PMS2 and somatic POLE exonuclease mutations cause hypermutability of the leading DNA strand in biallelic mismatch repair deficiency syndrome brain tumours. J Pathol. 2017 11; 243(3):331-341. PMID: 28805995.
    Citations: 8     Fields:    Translation:HumansCells
  8. Andrianova MA, Bazykin GA, Nikolaev SI, Seplyarskiy VB. Human mismatch repair system balances mutation rates between strands by removing more mismatches from the lagging strand. Genome Res. 2017 08; 27(8):1336-1343. PMID: 28512192; PMCID: PMC5538550.
    Citations: 19     Fields:    Translation:HumansCells
  9. Terekhanova NV, Seplyarskiy VB, Soldatov RA, Bazykin GA. Evolution of Local Mutation Rate and Its Determinants. Mol Biol Evol. 2017 05 01; 34(5):1100-1109. PMID: 28138076; PMCID: PMC5850301.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  10. Seplyarskiy VB, Andrianova MA, Bazykin GA. APOBEC3A/B-induced mutagenesis is responsible for 20% of heritable mutations in the TpCpW context. Genome Res. 2017 02; 27(2):175-184. PMID: 27940951; PMCID: PMC5287224.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  11. Bonilla X, Parmentier L, King B, Bezrukov F, Kaya G, Zoete V, Seplyarskiy VB, Sharpe HJ, McKee T, Letourneau A, Ribaux PG, Popadin K, Basset-Seguin N, Ben Chaabene R, Santoni FA, Andrianova MA, Guipponi M, Garieri M, Verdan C, Grosdemange K, Sumara O, Eilers M, Aifantis I, Michielin O, de Sauvage FJ, Antonarakis SE, Nikolaev SI. Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma. Nat Genet. 2016 Apr; 48(4):398-406. PMID: 26950094.
    Citations: 178     Fields:    Translation:HumansCells
  12. Seplyarskiy VB, Soldatov RA, Popadin KY, Antonarakis SE, Bazykin GA, Nikolaev SI. APOBEC-induced mutations in human cancers are strongly enriched on the lagging DNA strand during replication. Genome Res. 2016 Feb; 26(2):174-82. PMID: 26755635; PMCID: PMC4728370.
    Citations: 92     Fields:    Translation:HumansCells
  13. Seplyarskiy VB, Bazykin GA, Soldatov RA. Polymerase ? Activity Is Linked to Replication Timing in Humans: Evidence from Mutational Signatures. Mol Biol Evol. 2015 Dec; 32(12):3158-72. PMID: 26376651.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  14. Baranova MA, Logacheva MD, Penin AA, Seplyarskiy VB, Safonova YY, Naumenko SA, Klepikova AV, Gerasimov ES, Bazykin GA, James TY, Kondrashov AS. Extraordinary Genetic Diversity in a Wood Decay Mushroom. Mol Biol Evol. 2015 Oct; 32(10):2775-83. PMID: 26163667; PMCID: PMC4576712.
    Citations: 19     Fields:    Translation:Animals
  15. Popadin KY, Gutierrez-Arcelus M, Lappalainen T, Buil A, Steinberg J, Nikolaev SI, Lukowski SW, Bazykin GA, Seplyarskiy VB, Ioannidis P, Zdobnov EM, Dermitzakis ET, Antonarakis SE. Gene age predicts the strength of purifying selection acting on gene expression variation in humans. Am J Hum Genet. 2014 Dec 04; 95(6):660-74. PMID: 25480033; PMCID: PMC4259975.
    Citations: 21     Fields:    Translation:HumansCells
  16. Seplyarskiy VB, Logacheva MD, Penin AA, Baranova MA, Leushkin EV, Demidenko NV, Klepikova AV, Kondrashov FA, Kondrashov AS, James TY. Crossing-over in a hypervariable species preferentially occurs in regions of high local similarity. Mol Biol Evol. 2014 Nov; 31(11):3016-25. PMID: 25135947.
    Citations: 7     Fields:    Translation:AnimalsCells
  17. Terekhanova NV, Bazykin GA, Neverov A, Kondrashov AS, Seplyarskiy VB. Prevalence of multinucleotide replacements in evolution of primates and Drosophila. Mol Biol Evol. 2013 Jun; 30(6):1315-25. PMID: 23447710.
    Citations: 13     Fields:    Translation:HumansAnimals
  18. Seplyarskiy VB, Kharchenko P, Kondrashov AS, Bazykin GA. Heterogeneity of the transition/transversion ratio in Drosophila and Hominidae genomes. Mol Biol Evol. 2012 Aug; 29(8):1943-55. PMID: 22337862.
    Citations: 16     Fields:    Translation:HumansAnimals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.