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Hiroshi Saito, Ph.D., M.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Clerin V, Saito H, Filipski KJ, Nguyen AH, Garren J, Kisucka J, Reyes M, Jüppner H. Selective pharmacological inhibition of the sodium-dependent phosphate cotransporter NPT2a promotes phosphate excretion. J Clin Invest. 2020 Nov 09. PMID: 32853180.
    Citations:    Fields:    
  2. Zwischenberger BA, Balasuriya BK, Harris DD, Nataraj N, Owen AM, Bruno MEC, Mukherjee S, Ortiz-Soriano V, O'Connor W, Ke C, Stromberg AJ, Chang PK, Neyra JA, Saito H, Starr ME. Adipose-Derived Inflammatory and Coagulant Mediators in Patients with Sepsis. Shock. 2020 Jun 02. PMID: 32496420.
    Citations:    Fields:    
  3. Owen AM, Patel SP, Smith JD, Balasuriya BK, Mori SF, Hawk GS, Stromberg AJ, Kuriyama N, Kaneki M, Rabchevsky AG, Butterfield TA, Esser KA, Peterson CA, Starr ME, Saito H. Chronic muscle weakness and mitochondrial dysfunction in the absence of sustained atrophy in a preclinical sepsis model. Elife. 2019 12 03; 8. PMID: 31793435.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  4. Saito H, Noda H, Gatault P, Bockenhauer D, Loke KY, Hiort O, Silve C, Sharwood E, Martin RM, Dillon MJ, Gillis D, Harris M, Rao SD, Pauli RM, Gardella TJ, Jüppner H. Progression of Mineral Ion Abnormalities in Patients With Jansen Metaphyseal Chondrodysplasia. J Clin Endocrinol Metab. 2018 07 01; 103(7):2660-2669. PMID: 29788189.
    Citations: 1     Fields:    Translation:HumansCells
  5. Steele AM, Starr ME, Saito H. Late Therapeutic Intervention with Antibiotics and Fluid Resuscitation Allows for a Prolonged Disease Course with High Survival in a Severe Murine Model of Sepsis. Shock. 2017 06; 47(6):726-734. PMID: 27879561.
    Citations: 8     Fields:    Translation:Animals
  6. Chen TH, Yen AM, Fann JC, Gordon P, Chen SL, Chiu SY, Hsu CY, Chang KJ, Lee WC, Yeoh KG, Saito H, Promthet S, Hamashima C, Maidin A, Robinson F, Zhao LZ. Clarifying the debate on population-based screening for breast cancer with mammography: A systematic review of randomized controlled trials on mammography with Bayesian meta-analysis and causal model. Medicine (Baltimore). 2017 Jan; 96(3):e5684. PMID: 28099330.
    Citations: 4     Fields:    Translation:HumansPHPublic Health
  7. Starr ME, Steele AM, Cohen DA, Saito H. Short-Term Dietary Restriction Rescues Mice From Lethal Abdominal Sepsis and Endotoxemia and Reduces the Inflammatory/Coagulant Potential of Adipose Tissue. Crit Care Med. 2016 07; 44(7):e509-19. PMID: 26646465.
    Citations: 9     Fields:    Translation:Animals
  8. Starr ME, Steele AM, Saito M, Hacker BJ, Evers BM, Saito H. A new cecal slurry preparation protocol with improved long-term reproducibility for animal models of sepsis. PLoS One. 2014; 9(12):e115705. PMID: 25531402.
    Citations: 22     Fields:    Translation:Animals
  9. Shinozaki S, Chang K, Sakai M, Shimizu N, Yamada M, Tanaka T, Nakazawa H, Ichinose F, Yamada Y, Ishigami A, Ito H, Ouchi Y, Starr ME, Saito H, Shimokado K, Stamler JS, Kaneki M. Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65. Sci Signal. 2014 Nov 11; 7(351):ra106. PMID: 25389371.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  10. Starr ME, Takahashi H, Okamura D, Zwischenberger BA, Mrazek AA, Ueda J, Stromberg AJ, Evers BM, Esmon CT, Saito H. Increased coagulation and suppressed generation of activated protein C in aged mice during intra-abdominal sepsis. . 2015 Jan 15; 308(2):H83-91. PMID: 25380813.
    Citations: 6     Translation:Animals
  11. Starr ME, Saito M, Evers BM, Saito H. Age-Associated Increase in Cytokine Production During Systemic Inflammation-II: The Role of IL-1ß in Age-Dependent IL-6 Upregulation in Adipose Tissue. J Gerontol A Biol Sci Med Sci. 2015 Dec; 70(12):1508-15. PMID: 25344820.
    Citations: 21     Fields:    Translation:AnimalsCells
  12. Starr ME, Saito H. Sepsis in old age: review of human and animal studies. Aging Dis. 2014 Apr; 5(2):126-36. PMID: 24729938.
    Citations: 30     
  13. Katakami N, Kunikane H, Takeda K, Takayama K, Sawa T, Saito H, Harada M, Yokota S, Ando K, Saito Y, Yokota I, Ohashi Y, Eguchi K. Prospective study on the incidence of bone metastasis (BM) and skeletal-related events (SREs) in patients (pts) with stage IIIB and IV lung cancer-CSP-HOR 13. J Thorac Oncol. 2014 Feb; 9(2):231-8. PMID: 24419421.
    Citations: 11     Fields:    Translation:Humans
  14. Mustain WC, Starr ME, Valentino JD, Cohen DA, Okamura D, Wang C, Evers BM, Saito H. Inflammatory cytokine gene expression in mesenteric adipose tissue during acute experimental colitis. PLoS One. 2013; 8(12):e83693. PMID: 24386254.
    Citations: 4     Fields:    Translation:Animals
  15. Starr ME, Hu Y, Stromberg AJ, Carmical JR, Wood TG, Evers BM, Saito H. Gene expression profile of mouse white adipose tissue during inflammatory stress: age-dependent upregulation of major procoagulant factors. Aging Cell. 2013 Apr; 12(2):194-206. PMID: 23279636.
    Citations: 21     Fields:    Translation:AnimalsCells
  16. Tucsek Z, Gautam T, Sonntag WE, Toth P, Saito H, Salomao R, Szabo C, Csiszar A, Ungvari Z. Aging exacerbates microvascular endothelial damage induced by circulating factors present in the serum of septic patients. J Gerontol A Biol Sci Med Sci. 2013 Jun; 68(6):652-60. PMID: 23183901.
    Citations: 22     Fields:    Translation:HumansAnimals
  17. Okamura D, Starr ME, Lee EY, Stromberg AJ, Evers BM, Saito H. Age-dependent vulnerability to experimental acute pancreatitis is associated with increased systemic inflammation and thrombosis. Aging Cell. 2012 Oct; 11(5):760-9. PMID: 22672542.
    Citations: 12     Fields:    Translation:Animals
  18. Starr ME, Saito H. Age-related increase in food spilling by laboratory mice may lead to significant overestimation of actual food consumption: implications for studies on dietary restriction, metabolism, and dose calculations. J Gerontol A Biol Sci Med Sci. 2012 Oct; 67(10):1043-8. PMID: 22451471.
    Citations: 5     Fields:    Translation:HumansAnimals
  19. Takahashi H, Okamura D, Starr ME, Saito H, Evers BM. Age-dependent reduction of the PI3K regulatory subunit p85a suppresses pancreatic acinar cell proliferation. Aging Cell. 2012 Apr; 11(2):305-14. PMID: 22212451.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  20. Starr ME, Ueda J, Yamamoto S, Evers BM, Saito H. The effects of aging on pulmonary oxidative damage, protein nitration, and extracellular superoxide dismutase down-regulation during systemic inflammation. Free Radic Biol Med. 2011 Jan 15; 50(2):371-80. PMID: 21092756.
    Citations: 28     Fields:    Translation:AnimalsCells
  21. Starr ME, Ueda J, Takahashi H, Weiler H, Esmon CT, Evers BM, Saito H. Age-dependent vulnerability to endotoxemia is associated with reduction of anticoagulant factors activated protein C and thrombomodulin. Blood. 2010 Jun 10; 115(23):4886-93. PMID: 20348393.
    Citations: 23     Fields:    Translation:Animals
  22. Starr ME, Evers BM, Saito H. Age-associated increase in cytokine production during systemic inflammation: adipose tissue as a major source of IL-6. J Gerontol A Biol Sci Med Sci. 2009 Jul; 64(7):723-30. PMID: 19377014.
    Citations: 45     Fields:    Translation:AnimalsCells
  23. Ueda J, Starr ME, Takahashi H, Du J, Chang LY, Crapo JD, Evers BM, Saito H. Decreased pulmonary extracellular superoxide dismutase during systemic inflammation. Free Radic Biol Med. 2008 Sep 15; 45(6):897-904. PMID: 18640266.
    Citations: 21     Fields:    Translation:AnimalsCells
  24. Ishige K, Tanaka M, Arakawa M, Saito H, Ito Y. Distinct nuclear factor-kappaB/Rel proteins have opposing modulatory effects in glutamate-induced cell death in HT22 cells. Neurochem Int. 2005 Dec; 47(8):545-55. PMID: 16183169.
    Citations: 5     Fields:    Translation:AnimalsCells
  25. Taniyama M, Tanabe M, Saito H, Ban Y, Nawata H, Yanase T. Subtle 17alpha-hydroxylase/17,20-lyase deficiency with homozygous Y201N mutation in an infertile woman. J Clin Endocrinol Metab. 2005 May; 90(5):2508-11. PMID: 15713706.
    Citations: 1     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.