Harvard Catalyst Profiles

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Jean-Christophe Delpech, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Clayton K, Delpech JC, Herron S, Iwahara N, Ericsson M, Saito T, Saido TC, Ikezu S, Ikezu T. Correction to: Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model. Mol Neurodegener. 2021 Apr 14; 16(1):24. PMID: 33853665.
    Citations:    Fields:    
  2. Clayton K, Delpech JC, Herron S, Iwahara N, Ericsson M, Saito T, Saido TC, Ikezu S, Ikezu T. Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model. Mol Neurodegener. 2021 03 22; 16(1):18. PMID: 33752701.
    Citations: 1     Fields:    
  3. Ruan Z, Delpech JC, Venkatesan Kalavai S, Van Enoo AA, Hu J, Ikezu S, Ikezu T. P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice. Mol Neurodegener. 2020 08 18; 15(1):47. PMID: 32811520.
    Citations: 1     Fields:    
  4. Ikezu S, Yeh H, Delpech JC, Woodbury ME, Van Enoo AA, Ruan Z, Sivakumaran S, You Y, Holland C, Guillamon-Vivancos T, Yoshii-Kitahara A, Botros MB, Madore C, Chao PH, Desani A, Manimaran S, Kalavai SV, Johnson WE, Butovsky O, Medalla M, Luebke JI, Ikezu T. Inhibition of colony stimulating factor 1 receptor corrects maternal inflammation-induced microglial and synaptic dysfunction and behavioral abnormalities. Mol Psychiatry. 2020 Feb 18. PMID: 32071385.
    Citations: 4     Fields:    
  5. You Y, Botros MB, Enoo AAV, Bockmiller A, Herron S, Delpech JC, Ikezu T. Cre-inducible Adeno Associated Virus-mediated Expression of P301L Mutant Tau Causes Motor Deficits and Neuronal Degeneration in the Substantia Nigra. Neuroscience. 2019 12 01; 422:65-74. PMID: 31689387.
    Citations: 2     Fields:    Translation:AnimalsCells
  6. Delpech JC, Herron S, Botros MB, Ikezu T. Neuroimmune Crosstalk through Extracellular Vesicles in Health and Disease. Trends Neurosci. 2019 05; 42(5):361-372. PMID: 30926143.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  7. Graham EM, Everett AD, Delpech JC, Northington FJ. Blood biomarkers for evaluation of perinatal encephalopathy: state of the art. Curr Opin Pediatr. 2018 04; 30(2):199-203. PMID: 29346139.
    Citations: 18     Fields:    Translation:HumansAnimals
  8. Johnson FK, Delpech JC, Thompson GJ, Wei L, Hao J, Herman P, Hyder F, Kaffman A. Amygdala hyper-connectivity in a mouse model of unpredictable early life stress. Transl Psychiatry. 2018 02 21; 8(1):49. PMID: 29463821.
    Citations: 19     Fields:    Translation:Animals
  9. Villéga F, Delpech JC, Griton M, André C, Franconi JM, Miraux S, Konsman JP. Circulating bacterial lipopolysaccharide-induced inflammation reduces flow in brain-irrigating arteries independently from cerebrovascular prostaglandin production. Neuroscience. 2017 03 27; 346:160-172. PMID: 28126368.
    Citations: 1     Fields:    Translation:Animals
  10. Delpech JC, Wei L, Hao J, Yu X, Madore C, Butovsky O, Kaffman A. Early life stress perturbs the maturation of microglia in the developing hippocampus. Brain Behav Immun. 2016 Oct; 57:79-93. PMID: 27301858.
    Citations: 36     Fields:    Translation:AnimalsCells
  11. Wohleb ES, Delpech JC. Dynamic cross-talk between microglia and peripheral monocytes underlies stress-induced neuroinflammation and behavioral consequences. Prog Neuropsychopharmacol Biol Psychiatry. 2017 10 03; 79(Pt A):40-48. PMID: 27154755.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  12. Delpech JC, Thomazeau A, Madore C, Bosch-Bouju C, Larrieu T, Lacabanne C, Remus-Borel J, Aubert A, Joffre C, Nadjar A, Layé S. Dietary n-3 PUFAs Deficiency Increases Vulnerability to Inflammation-Induced Spatial Memory Impairment. Neuropsychopharmacology. 2015 Nov; 40(12):2774-87. PMID: 25948102.
    Citations: 15     Fields:    Translation:AnimalsCells
  13. Delpech JC, Saucisse N, Parkes SL, Lacabanne C, Aubert A, Casenave F, Coutureau E, Sans N, Layé S, Ferreira G, Nadjar A. Microglial activation enhances associative taste memory through purinergic modulation of glutamatergic neurotransmission. J Neurosci. 2015 Feb 18; 35(7):3022-33. PMID: 25698740.
    Citations: 5     Fields:    Translation:AnimalsCells
  14. Delpech JC, Madore C, Nadjar A, Joffre C, Wohleb ES, Layé S. Microglia in neuronal plasticity: Influence of stress. Neuropharmacology. 2015 Sep; 96(Pt A):19-28. PMID: 25582288.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  15. Delpech JC, Madore C, Joffre C, Aubert A, Kang JX, Nadjar A, Layé S. Transgenic increase in n-3/n-6 fatty acid ratio protects against cognitive deficits induced by an immune challenge through decrease of neuroinflammation. Neuropsychopharmacology. 2015 Feb; 40(3):525-36. PMID: 25228141.
    Citations: 20     Fields:    Translation:AnimalsCells
  16. Madore C, Nadjar A, Delpech JC, Sere A, Aubert A, Portal C, Joffre C, Layé S. Nutritional n-3 PUFAs deficiency during perinatal periods alters brain innate immune system and neuronal plasticity-associated genes. Brain Behav Immun. 2014 Oct; 41:22-31. PMID: 24735929.
    Citations: 37     Fields:    Translation:AnimalsCells
  17. Sauvant J, Delpech JC, Palin K, De Mota N, Dudit J, Aubert A, Orcel H, Roux P, Layé S, Moos F, Llorens-Cortes C, Nadjar A. Mechanisms involved in dual vasopressin/apelin neuron dysfunction during aging. PLoS One. 2014; 9(2):e87421. PMID: 24505289.
    Citations: 8     Fields:    Translation:AnimalsCells
  18. Moranis A, Delpech JC, De Smedt-Peyrusse V, Aubert A, Guesnet P, Lavialle M, Joffre C, Layé S. Long term adequate n-3 polyunsaturated fatty acid diet protects from depressive-like behavior but not from working memory disruption and brain cytokine expression in aged mice. Brain Behav Immun. 2012 Jul; 26(5):721-31. PMID: 22085587.
    Citations: 23     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.