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Leilah K. Grant, Ph.D.

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Biography
Monash University, AustraliaBSc (Hons)10/2013Psychology
Monash University, AustraliaPhD07/2018Psychological Medicine
2017
Abstract Excellence Award - Australian Chronobiology Society
2019
Certificate of Distinction in Teaching - Derek Bok Center, Harvard University
2020
Abstract Merit Award - Society for Research on Biological Rhythms
2020
Research Excellence Award - Brigham Research Institute
2021
Outstanding Abstract Award - Endocrine Society

Overview
Dr. Grant is an Associate Physiologist in the Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, and an Instructor in Medicine, Harvard Medical School. Her research focuses on the effects of sleep, the circadian system and light on behavioral, metabolic, and endocrine outcomes in humans.

Sleep and circadian rhythms in women’s health
A primary focus of Dr. Grant’s research is understanding sleep and circadian control of metabolism, reproduction, and cognition in women. This work has examined menstrual cycle regulation of 1) vulnerability to neurobehavioral impairment associated with sleep loss and adverse circadian timing; and 2) circadian and diurnal rhythms in female sex hormones in premenopausal women. In ongoing work, she is exploring the effects of menopause-related sleep and hormone changes on metabolism (nutrient utilization and energy expenditure) and cognition.

Shift work and metabolism
While light is the primary time cue for entraining central circadian rhythms, such as melatonin, peripheral metabolic rhythms may be more responsive to other time cues, for example food. Dr. Grant’s recent work has shown that 1) eating at night, as many shift workers do, acutely effects lipid levels in addition to causing internal desynchrony in the timing of lipid rhythms, and 2) lipid and hepatic rhythms show differential resetting compared to melatonin in response to simulated shift work paradigms, suggesting that light may not be the primary time cue for resetting some metabolic rhythms. Her ongoing work is examining how acute metabolic responses to food change with circadian phase.

Non-visual effects of light
In addition to allowing us to see, light has a number of ‘non-visual’ benefits including improved alertness, sleep and mood. Dr. Grant has studied the acute alerting effects of light 1) as a countermeasure to mitigate vulnerability to performance impairment overnight in the follicular phase of the menstrual cycle, and 2) to improve alertness, performance and learning in moderately sleep restricted college-aged adults. Currently, she is examining whether supplementing sub-optimal ambient lighting with a task lamp can improve alertness, mood, and cognition.

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Grant LK, St Hilaire MA, Brainard GC, Czeisler CA, Lockley SW, Rahman SA. Endogenous circadian regulation and phase resetting of clinical metabolic biomarkers. J Pineal Res. 2021 Jun 12; e12752. PMID: 34118084.
    Citations:    Fields:    
  2. Grant LK, Czeisler CA, Lockley SW, Rahman SA. Time-of-day and Meal Size Effects on Clinical Lipid Markers. J Clin Endocrinol Metab. 2021 Mar 08; 106(3):e1373-e1379. PMID: 33051649.
    Citations:    Fields:    
  3. Grant LK, Kent BA, Mayer MD, Stickgold R, Lockley SW, Rahman SA. Daytime Exposure to Short Wavelength-Enriched Light Improves Cognitive Performance in Sleep-Restricted College-Aged Adults. Front Neurol. 2021; 12:624217. PMID: 33692742.
    Citations:    
  4. Grant LK, Gooley JJ, St Hilaire MA, Rajaratnam SMW, Brainard GC, Czeisler CA, Lockley SW, Rahman SA. Menstrual phase-dependent differences in neurobehavioral performance: the role of temperature and the progesterone/estradiol ratio. Sleep. 2020 02 13; 43(2). PMID: 31670824.
    Citations: 1     Fields:    Translation:Humans
  5. Rahman SA, Grant LK, Gooley JJ, Rajaratnam SMW, Czeisler CA, Lockley SW. Endogenous Circadian Regulation of Female Reproductive Hormones. J Clin Endocrinol Metab. 2019 12 01; 104(12):6049-6059. PMID: 31415086.
    Citations: 6     Fields:    Translation:Humans
  6. Grant LK, Ftouni S, Nijagal B, De Souza DP, Tull D, McConville MJ, Rajaratnam SMW, Lockley SW, Anderson C. Circadian and wake-dependent changes in human plasma polar metabolites during prolonged wakefulness: A preliminary analysis. Sci Rep. 2019 03 14; 9(1):4428. PMID: 30872634.
    Citations: 9     Fields:    Translation:Humans
  7. Grant LK, Cain SW, Chang AM, Saxena R, Czeisler CA, Anderson C. Impaired cognitive flexibility during sleep deprivation among carriers of the Brain Derived Neurotrophic Factor (BDNF) Val66Met allele. Behav Brain Res. 2018 02 15; 338:51-55. PMID: 28947280.
    Citations: 2     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.