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Alexander Fischer

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Fischer AW, Behrens J, Sass F, Schlein C, Heine M, Pertzborn P, Scheja L, Heeren J. Brown adipose tissue lipoprotein and glucose disposal is not determined by thermogenesis in UCP1- deficient mice. J Lipid Res. 2020 Aug 07. PMID: 32769145.
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  2. Cannon B, de Jong JMA, Fischer AW, Nedergaard J, Petrovic N. Human brown adipose tissue: Classical brown rather than brite/beige? Exp Physiol. 2020 May 07. PMID: 32378255.
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  3. Fischer AW, Cannon B, Nedergaard J. Leptin: Is It Thermogenic? Endocr Rev. 2020 Apr 01; 41(2). PMID: 31774114.
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  4. Fischer AW, Cannon B, Nedergaard J. No insulating effect of obesity, neither in mice nor in humans. Am J Physiol Endocrinol Metab. 2019 11 01; 317(5):E952-E953. PMID: 31697209.
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  5. de Jong JMA, Sun W, Pires ND, Frontini A, Balaz M, Jespersen NZ, Feizi A, Petrovic K, Fischer AW, Bokhari MH, Niemi T, Nuutila P, Cinti S, Nielsen S, Scheele C, Virtanen K, Cannon B, Nedergaard J, Wolfrum C, Petrovic N. Author Correction: Human brown adipose tissue is phenocopied by classical brown adipose tissue in physiologically humanized mice. Nat Metab. 2019 Sep; 1(9):927. PMID: 32747808.
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  6. de Jong JMA, Sun W, Pires ND, Frontini A, Balaz M, Jespersen NZ, Feizi A, Petrovic K, Fischer AW, Bokhari MH, Niemi T, Nuutila P, Cinti S, Nielsen S, Scheele C, Virtanen K, Cannon B, Nedergaard J, Wolfrum C, Petrovic N. Human brown adipose tissue is phenocopied by classical brown adipose tissue in physiologically humanized mice. Nat Metab. 2019 Aug; 1(8):830-843. PMID: 32694768.
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  7. Jasper M. A. de Jong, Wenfei Sun, Nuno D. Pires, Andrea Frontini, Miroslav Balaz, Naja Z. Jespersen, Amir Feizi, Katarina Petrovic, Alexander W. Fischer, Muhammad Hamza Bokhari, Tarja Niemi, Pirjo Nuutila, Saverio Cinti, Søren Nielsen, Camilla Scheele, Kirsi Virtanen, Barbara Cannon, Jan Nedergaard, Christian Wolfrum , Natasa Petrovic. Human brown adipose tissue is phenocopied by classical brown adipose tissue in physiologically humanized mice. Nature Metabolism. 2019; 1:830–843. View Publication.
  8. Johann K, Cremer AL, Fischer AW, Heine M, Pensado ER, Resch J, Nock S, Virtue S, Harder L, Oelkrug R, Astiz M, Brabant G, Warner A, Vidal-Puig A, Oster H, Boelen A, López M, Heeren J, Dalley JW, Backes H, Mittag J. Thyroid-Hormone-Induced Browning of White Adipose Tissue Does Not Contribute to Thermogenesis and Glucose Consumption. Cell Rep. 2019 06 11; 27(11):3385-3400.e3. PMID: 31189119.
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  9. Fischer AW, Cannon B, Nedergaard J. The answer to the question "What is the best housing temperature to translate mouse experiments to humans?" is: thermoneutrality. Mol Metab. 2019 08; 26:1-3. PMID: 31155502.
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  10. Luijten IHN, Brooks K, Boulet N, Shabalina IG, Jaiprakash A, Carlsson B, Fischer AW, Cannon B, Nedergaard J. Glucocorticoid-Induced Obesity Develops Independently of UCP1. Cell Rep. 2019 05 07; 27(6):1686-1698.e5. PMID: 31067456.
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  11. Pauter AM, Fischer AW, Bengtsson T, Asadi A, Talamonti E, Jacobsson A. Synergistic Effects of DHA and Sucrose on Body Weight Gain in PUFA-Deficient Elovl2 -/- Mice. Nutrients. 2019 Apr 15; 11(4). PMID: 30991731.
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  12. Schulze ML, Lemoine MD, Fischer AW, Scherschel K, David R, Riecken K, Hansen A, Eschenhagen T, Ulmer BM. Dissecting hiPSC-CM pacemaker function in a cardiac organoid model. Biomaterials. 2019 06; 206:133-145. PMID: 30933775.
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  13. Fischer AW, Albers K, Schlein C, Sass F, Krott LM, Schmale H, Gordts PLSM, Scheja L, Heeren J. PID1 regulates insulin-dependent glucose uptake by controlling intracellular sorting of GLUT4-storage vesicles. Biochim Biophys Acta Mol Basis Dis. 2019 06 01; 1865(6):1592-1603. PMID: 30904610.
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  14. Fischer AW, Schlein C, Cannon B, Heeren J, Nedergaard J. Intact innervation is essential for diet-induced recruitment of brown adipose tissue. Am J Physiol Endocrinol Metab. 2019 03 01; 316(3):E487-E503. PMID: 30576247.
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  15. Cairns R, Fischer AW, Blanco-Munoz P, Alvarez-Guaita A, Meneses-Salas E, Egert A, Buechler C, Hoy AJ, Heeren J, Enrich C, Rentero C, Grewal T. Altered hepatic glucose homeostasis in AnxA6-KO mice fed a high-fat diet. PLoS One. 2018; 13(8):e0201310. PMID: 30110341.
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  16. Fischer AW, Albers K, Krott LM, Hoffzimmer B, Heine M, Schmale H, Scheja L, Gordts PLSM, Heeren J. The adaptor protein PID1 regulates receptor-dependent endocytosis of postprandial triglyceride-rich lipoproteins. Mol Metab. 2018 10; 16:88-99. PMID: 30100244.
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  17. Heine M, Fischer AW, Schlein C, Jung C, Straub LG, Gottschling K, Mangels N, Yuan Y, Nilsson SK, Liebscher G, Chen O, Schreiber R, Zechner R, Scheja L, Heeren J. Lipolysis Triggers a Systemic Insulin Response Essential for Efficient Energy Replenishment of Activated Brown Adipose Tissue in Mice. Cell Metab. 2018 10 02; 28(4):644-655.e4. PMID: 30033199.
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  18. Jayson CBK, Arlt H, Fischer AW, Lai ZW, Farese RV, Walther TC. Rab18 is not necessary for lipid droplet biogenesis or turnover in human mammary carcinoma cells. Mol Biol Cell. 2018 08 15; 29(17):2045-2054. PMID: 29949452.
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  19. Lee SX, Heine M, Schlein C, Ramakrishnan R, Liu J, Belnavis G, Haimi I, Fischer AW, Ginsberg HN, Heeren J, Rinninger F, Haeusler RA. FoxO transcription factors are required for hepatic HDL cholesterol clearance. J Clin Invest. 2018 04 02; 128(4):1615-1626. PMID: 29408809.
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  20. Bartelt A, Widenmaier SB, Schlein C, Johann K, Goncalves RLS, Eguchi K, Fischer AW, Parlakgül G, Snyder NA, Nguyen TB, Bruns OT, Franke D, Bawendi MG, Lynes MD, Leiria LO, Tseng YH, Inouye KE, Arruda AP, Hotamisligil GS. Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity. Nat Med. 2018 03; 24(3):292-303. PMID: 29400713.
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  21. Fischer AW, Cannon B, Nedergaard J. Optimal housing temperatures for mice to mimic the thermal environment of humans: An experimental study. Mol Metab. 2018 01; 7:161-170. PMID: 29122558.
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  22. Talamonti E, Pauter AM, Asadi A, Fischer AW, Chiurchiù V, Jacobsson A. Impairment of systemic DHA synthesis affects macrophage plasticity and polarization: implications for DHA supplementation during inflammation. Cell Mol Life Sci. 2017 08; 74(15):2815-2826. PMID: 28299384.
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  23. Fischer AW, Shabalina IG, Mattsson CL, Abreu-Vieira G, Cannon B, Nedergaard J, Petrovic N. UCP1 inhibition in Cidea-overexpressing mice is physiologically counteracted by brown adipose tissue hyperrecruitment. Am J Physiol Endocrinol Metab. 2017 01 01; 312(1):E72-E87. PMID: 27923808.
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  24. Fischer AW, Cannon B, Nedergaard J. Leptin-deficient mice are not hypothermic, they are anapyrexic. Mol Metab. 2017 02; 6(2):173. PMID: 28180058.
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  25. Fischer AW, Csikasz RI, von Essen G, Cannon B, Nedergaard J. Reply to letter to the editor: at thermoneutrality, neither the lean nor the obese freeze. Am J Physiol Endocrinol Metab. 2016 09 01; 311(3):E639. PMID: 27619918.
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  26. Abreu-Vieira G, Fischer AW, Mattsson C, de Jong JMA, Shabalina IG, Rydén M, Laurencikiene J, Arner P, Cannon B, Nedergaard J, Petrovic N. Corrigendum: Cidea improves the metabolic profile through expansion of adipose tissue. Nat Commun. 2016 08 04; 7:12395. PMID: 27488677.
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  27. Fischer AW, Csikasz RI, von Essen G, Cannon B, Nedergaard J. No insulating effect of obesity. Am J Physiol Endocrinol Metab. 2016 Jul 01; 311(1):E202-13. PMID: 27189935.
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  28. Fischer AW, Hoefig CS, Abreu-Vieira G, de Jong JMA, Petrovic N, Mittag J, Cannon B, Nedergaard J. Leptin Raises Defended Body Temperature without Activating Thermogenesis. Cell Rep. 2016 Feb 23; 14(7):1621-1631. PMID: 26876182.
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  29. Schlein C, Talukdar S, Heine M, Fischer AW, Krott LM, Nilsson SK, Brenner MB, Heeren J, Scheja L. FGF21 Lowers Plasma Triglycerides by Accelerating Lipoprotein Catabolism in White and Brown Adipose Tissues. Cell Metab. 2016 Mar 08; 23(3):441-53. PMID: 26853749.
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  30. Abreu-Vieira G, Fischer AW, Mattsson C, de Jong JM, Shabalina IG, Rydén M, Laurencikiene J, Arner P, Cannon B, Nedergaard J, Petrovic N. Cidea improves the metabolic profile through expansion of adipose tissue. Nat Commun. 2015 Jun 29; 6:7433. PMID: 26118629.
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  31. Hoffmann LS, Etzrodt J, Willkomm L, Sanyal A, Scheja L, Fischer AWC, Stasch JP, Bloch W, Friebe A, Heeren J, Pfeifer A. Stimulation of soluble guanylyl cyclase protects against obesity by recruiting brown adipose tissue. Nat Commun. 2015 May 26; 6:7235. PMID: 26011238.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.