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Timothy T Hla, Ph.D.

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Fellow of the AAAS
MD(honoris causa), Goethe University
Outstanding achievement award, Eicosanoid research foundation
Siegel award for outstanding medical research, Weill Cornell Medical College
Honorary Member, Japanese Biochemical Society
Established Investigator, AHA
1988 - 1991
Postdoctoral fellowship award, Arthritis Foundation

Tim Hla's laboratory has been investigating the role of lipid mediators, sphingosine 1-phosphate (S1P) and prostanoids in vascular biology and disease. In the 1990s, we cloned the inducible cyclooxygenase (COX-2) and the first S1P receptor. Our work defined how the COX-2 pathway regulates angiogenesis, cancer and inflammatory disease. Recently, we are examining molecular mechanisms by which prostanoids interact with other lipid signaling systems to protect the vascular system and maintain health. Secondly, since our discovery of the S1P receptor, we have been working on how this novel signaling pathway regulates vascular development, homeostasis and is dysregulated in vascular diseases. In addition, our work contributed to the development of S1P receptor inhibitors, which are being used for the treatment of a number of autoimmune diseases. Recently, we discovered that HDL-bound S1P activates vascular S1P receptors to inhibit vascular injury and disease. We also showed that proteins that bind to S1P, such as the HDL-bound apolipoprotein M (ApoM), direct specific biological functions of S1P by activating S1P receptors in unique ways. This mode of signaling, termed as, chaperone-dependent S1P signaling, may be a general mechanism for lipid mediators that are poorly soluble in water. We are also examining novel mechanisms of S1P metabolism, export into the extracellular environment, capture and signaling by novel chaperones, receptor-dependent signaling mechanisms and cross-talk with other cytokine, growth factor signaling pathways. Such mechanistic information is useful not only to achieve a deeper understanding of vascular health and disease but also to develop new therapeutic entities. In fact, our laboratory is developing novel small molecules as well as protein biotherapeutics to modulate heart disease, stroke, autoimmune diseases, eye disease and cancer.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01EY031715 (HLA, TIMOTHY TUN) May 1, 2021 - Mar 31, 2026
    G protein-coupled receptor regulation of transcriptional mechanisms in the retinal vasculature.
    Role: Principal Investigator
  2. R56AG069825 (HLA, TIMOTHY TUN) Sep 15, 2020 - Aug 31, 2021
    Sphingolipid signaling in age-associated vascular pathology
    Role: Principal Investigator
  3. R35HL135821 (HLA, TIMOTHY TUN) Jan 18, 2017 - Dec 31, 2023
    Mechanisms of sphingolipid signaling in vascular health and disease
    Role: Principal Investigator
  4. Transatlantic Network Grant (Hla/ Betsholtz) Sep 1, 2014 - Aug 30, 2019
    Fondation Leducq
    Sphingolipid mediators in neurovascular biology and disease
    Role: Principle investigator
  5. R13HL117380 (HLA, TIMOTHY TUN) Jan 22, 2013 - Jan 21, 2014
    2013 Vascular Cell Biology Gordon Research Conference
    Role: Principal Investigator

Featured Content

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Levesque MV, Hla T. Signal Transduction and Gene Regulation in the Endothelium. Cold Spring Harb Perspect Med. 2023 Jan 03; 13(1). PMID: 35667710; PMCID: PMC9722983.
    Citations:    Fields:    
  2. Kuo A, Checa A, Niaudet C, Jung B, Fu Z, Wheelock CE, Singh SA, Aikawa M, Smith LE, Proia RL, Hla T. Murine endothelial serine palmitoyltransferase 1 (SPTLC1) is required for vascular development and systemic sphingolipid homeostasis. Elife. 2022 Oct 05; 11. PMID: 36197001; PMCID: PMC9578713.
    Citations:    Fields:    Translation:AnimalsCells
  3. Subbaramaiah K, Howe LR, Bhardwaj P, Du B, Gravaghi C, Yantiss RK, Zhou XK, Blaho VA, Hla T, Yang P, Kopelovich L, Hudis CA, Dannenberg AJ. Retraction: Obesity Is Associated With Inflammation and Elevated Aromatase Expression in the Mouse Mammary Gland. Cancer Prev Res (Phila). 2022 06 02; 15(6):413. PMID: 35652231; PMCID: PMC9272560.
    Citations:    Fields:    
  4. Burg N, Salmon JE, Hla T. Sphingosine 1-phosphate receptor-targeted therapeutics in rheumatic diseases. Nat Rev Rheumatol. 2022 06; 18(6):335-351. PMID: 35508810; PMCID: PMC9641499.
    Citations: 1     Fields:    Translation:HumansCells
  5. Shia X, Wang W, Li J, Wang T, Lin Y, Huang S, Kuver A, Chen C, Hla T, Li X, Dai K. Corrigendum to "Sphingosine 1-phosphate receptor 1 regulates cell-surface localization of membrane proteins in endothelial cells" [Biochim Biophys Acta Gen Subj. volume 1863 (6) (2019) 1079-1087]. Biochim Biophys Acta Gen Subj. 2022 Aug; 1866(8):130138. PMID: 35501212.
    Citations:    Fields:    
  6. Yazbeck P, Cullere X, Bennett P, Yajnik V, Wang H, Kawada K, Davis VM, Parikh A, Kuo A, Mysore V, Hla T, Milstone DS, Mayadas TN. DOCK4 Regulation of Rho GTPases Mediates Pulmonary Vascular Barrier Function. Arterioscler Thromb Vasc Biol. 2022 07; 42(7):886-902. PMID: 35477279; PMCID: PMC9233130.
    Citations:    Fields:    Translation:AnimalsCells
  7. Knipe RS, Spinney JJ, Abe EA, Probst CK, Franklin A, Logue A, Giacona F, Drummond M, Griffith J, Brazee PL, Hariri LP, Montesi SB, Black KE, Hla T, Kuo A, Cartier A, Engelbrecht E, Christoffersen C, Shea BS, Tager AM, Medoff BD. Endothelial-Specific Loss of Sphingosine-1-Phosphate Receptor 1 Increases Vascular Permeability and Exacerbates Bleomycin-induced Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2022 01; 66(1):38-52. PMID: 34343038; PMCID: PMC8803357.
    Citations: 1     Fields:    Translation:AnimalsCells
  8. Diebel LN, Liberati DM, Hla T, Swendeman S. Plasma components to protect the endothelial barrier after shock: A role for sphingosine 1-phosphate. Surgery. 2022 03; 171(3):825-832. PMID: 34865862.
    Citations:    Fields:    Translation:HumansCells
  9. Kano K, Aoki J, Hla T. Lysophospholipid Mediators in Health and Disease. Annu Rev Pathol. 2022 01 24; 17:459-483. PMID: 34813354; PMCID: PMC9641500.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  10. Del Gaudio I, Rubinelli L, Sasset L, Wadsack C, Hla T, Di Lorenzo A. Endothelial Spns2 and ApoM Regulation of Vascular Tone and Hypertension Via Sphingosine-1-Phosphate. J Am Heart Assoc. 2021 07 20; 10(14):e021261. PMID: 34240614.
    Citations: 6     Fields:    Translation:Animals
  11. Mao Y, Kleinjan ML, Jilishitz I, Swaminathan B, Obinata H, Komarova YA, Bayless KJ, Hla T, Kitajewski JK. CLIC1 and CLIC4 mediate endothelial S1P receptor signaling to facilitate Rac1 and RhoA activity and function. Sci Signal. 2021 04 20; 14(679). PMID: 33879602; PMCID: PMC8722429.
    Citations: 2     Fields:    Translation:AnimalsCells
  12. Hla T. Support Myanmar's embattled scientists and students. Nature. 2021 04; 592(7855):507. PMID: 33879888.
    Citations:    Fields:    Translation:Humans
  13. Engelbrecht E, MacRae CA, Hla T. Lysolipids in Vascular Development, Biology, and Disease. Arterioscler Thromb Vasc Biol. 2021 02; 41(2):564-584. PMID: 33327749; PMCID: PMC8105276.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  14. Nitzsche A, Poittevin M, Benarab A, Bonnin P, Faraco G, Uchida H, Favre J, Garcia-Bonilla L, Garcia MCL, Léger PL, Thérond P, Mathivet T, Autret G, Baudrie V, Couty L, Kono M, Chevallier A, Niazi H, Tharaux PL, Chun J, Schwab SR, Eichmann A, Tavitian B, Proia RL, Charriaut-Marlangue C, Sanchez T, Kubis N, Henrion D, Iadecola C, Hla T, Camerer E. Endothelial S1P1 Signaling Counteracts Infarct Expansion in Ischemic Stroke. Circ Res. 2021 02 05; 128(3):363-382. PMID: 33301355; PMCID: PMC7874503.
    Citations: 15     Fields:    Translation:AnimalsCells
  15. Geng X, Yanagida K, Akwii RG, Choi D, Chen L, Ho Y, Cha B, Mahamud MR, Berman de Ruiz K, Ichise H, Chen H, Wythe JD, Mikelis CM, Hla T, Srinivasan RS. S1PR1 regulates the quiescence of lymphatic vessels by inhibiting laminar shear stress-dependent VEGF-C signaling. JCI Insight. 2020 07 23; 5(14). PMID: 32544090; PMCID: PMC7453895.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  16. Ding BS, Yang D, Swendeman SL, Christoffersen C, Nielsen LB, Friedman SL, Powell CA, Hla T, Cao Z. Aging Suppresses Sphingosine-1-Phosphate Chaperone ApoM in Circulation Resulting in Maladaptive Organ Repair. Dev Cell. 2020 06 22; 53(6):677-690.e4. PMID: 32544390.
    Citations: 12     Fields:    Translation:AnimalsCells
  17. Engelbrecht E, Levesque MV, He L, Vanlandewijck M, Nitzsche A, Niazi H, Kuo A, Singh SA, Aikawa M, Holton K, Proia RL, Kono M, Pu WT, Camerer E, Betsholtz C, Hla T. Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta. Elife. 2020 02 24; 9. PMID: 32091396.
    Citations: 15     Fields:    Translation:AnimalsCells
  18. Yanagida K, Engelbrecht E, Niaudet C, Jung B, Gaengel K, Holton K, Swendeman S, Liu CH, Levesque MV, Kuo A, Fu Z, Smith LEH, Betsholtz C, Hla T. Sphingosine 1-Phosphate Receptor Signaling Establishes AP-1 Gradients to Allow for Retinal Endothelial Cell Specialization. Dev Cell. 2020 03 23; 52(6):779-793.e7. PMID: 32059774.
    Citations: 16     Fields:    Translation:AnimalsCells
  19. Pandey S, Banks KM, Kumar R, Kuo A, Wen D, Hla T, Evans T. Sphingosine kinases protect murine embryonic stem cells from sphingosine-induced cell cycle arrest. Stem Cells. 2020 05; 38(5):613-623. PMID: 31916656.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  20. Cartier A, Leigh T, Liu CH, Hla T. Endothelial sphingosine 1-phosphate receptors promote vascular normalization and antitumor therapy. Proc Natl Acad Sci U S A. 2020 02 11; 117(6):3157-3166. PMID: 31988136; PMCID: PMC7022165.
    Citations: 25     Fields:    Translation:AnimalsCells
  21. Subbaramaiah K, Hudis C, Chang SH, Hla T, Dannenberg AJ. Withdrawal: EP2 and EP4 receptors regulate aromatase expression in human adipocytes and breast cancer cells: Evidence of a BRCA1 and p300 exchange. J Biol Chem. 2020 01 03; 295(1):295. PMID: 31900377.
    Citations:    Fields:    
  22. Subbaramaiah K, Hudis C, Chang SH, Hla T, Dannenberg AJ. Withdrawal: EP2 and EP4 receptors regulate aromatase expression in human adipocytes and breast cancer cells: Evidence of a BRCA1 and p300 exchange. J Biol Chem. 2020 Jan 03; 295(1):295. PMID: 33518006.
    Citations:    Fields:    
  23. Poganik JR, Long MJC, Disare MT, Liu X, Chang SH, Hla T, Aye Y. Post-transcriptional regulation of Nrf2-mRNA by the mRNA-binding proteins HuR and AUF1. FASEB J. 2019 12; 33(12):14636-14652. PMID: 31665914; PMCID: PMC6993928.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  24. Cartier A, Hla T. Sphingosine 1-phosphate: Lipid signaling in pathology and therapy. Science. 2019 10 18; 366(6463). PMID: 31624181.
    Citations: 107     Fields:    Translation:HumansAnimalsCells
  25. Singh RK, Haka AS, Asmal A, Barbosa-Lorenzi VC, Grosheva I, Chin HF, Xiong Y, Hla T, Maxfield FR. TLR4 (Toll-Like Receptor 4)-Dependent Signaling Drives Extracellular Catabolism of LDL (Low-Density Lipoprotein) Aggregates. Arterioscler Thromb Vasc Biol. 2020 01; 40(1):86-102. PMID: 31597445.
    Citations: 18     Fields:    Translation:AnimalsCells
  26. Obinata H, Kuo A, Wada Y, Swendeman S, Liu CH, Blaho VA, Nagumo R, Satoh K, Izumi T, Hla T. Identification of ApoA4 as a sphingosine 1-phosphate chaperone in ApoM- and albumin-deficient mice. J Lipid Res. 2019 11; 60(11):1912-1921. PMID: 31462513.
    Citations: 17     Fields:    Translation:AnimalsCells
  27. Obinata H, Hla T. Sphingosine 1-phosphate and inflammation. Int Immunol. 2019 08 23; 31(9):617-625. PMID: 31049553; PMCID: PMC6939830.
    Citations: 65     Fields:    Translation:HumansAnimalsCells
  28. Tsai HC, Nguyen K, Hashemi E, Engleman E, Hla T, Han MH. Myeloid sphingosine-1-phosphate receptor 1 is important for CNS autoimmunity and neuroinflammation. J Autoimmun. 2019 12; 105:102290. PMID: 31202617.
    Citations: 10     Fields:    Translation:AnimalsCells
  29. Inoue T, Kohno M, Nagahara H, Murakami K, Sagawa T, Kasahara A, Kaneshita S, Kida T, Fujioka K, Wada M, Nakada H, Hla T, Kawahito Y. Upregulation of sphingosine-1-phosphate receptor 3 on fibroblast-like synoviocytes is associated with the development of collagen-induced arthritis via increased interleukin-6 production. PLoS One. 2019; 14(6):e0218090. PMID: 31173610; PMCID: PMC6555509.
    Citations: 10     Fields:    Translation:AnimalsCells
  30. Hisano Y, Kono M, Cartier A, Engelbrecht E, Kano K, Kawakami K, Xiong Y, Piao W, Galvani S, Yanagida K, Kuo A, Ono Y, Ishida S, Aoki J, Proia RL, Bromberg JS, Inoue A, Hla T. Lysolipid receptor cross-talk regulates lymphatic endothelial junctions in lymph nodes. J Exp Med. 2019 07 01; 216(7):1582-1598. PMID: 31147448; PMCID: PMC6605750.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  31. Shi X, Wang W, Li J, Wang T, Lin Y, Huang S, Kuver A, Chen C, Hla T, Li X, Dai K. Sphingosine 1-phosphate receptor 1 regulates cell-surface localization of membrane proteins in endothelial cells. Biochim Biophys Acta Gen Subj. 2019 06; 1863(6):1079-1087. PMID: 30954526.
    Citations: 4     Fields:    Translation:AnimalsCells
  32. Ban Y, Dong W, Zhang L, Zhou T, Altiti AS, Ali K, Mootoo DR, Blaho VA, Hla T, Ren Y, Ma X. Abrogation of Endogenous Glycolipid Antigen Presentation on Myelin-Laden Macrophages by D-Sphingosine Ameliorates the Pathogenesis of Experimental Autoimmune Encephalomyelitis. Front Immunol. 2019; 10:404. PMID: 30941120.
    Citations: 1     Fields:    Translation:AnimalsCells
  33. Xiong Y, Piao W, Brinkman CC, Li L, Kulinski JM, Olivera A, Cartier A, Hla T, Hippen KL, Blazar BR, Schwab SR, Bromberg JS. CD4 T cell sphingosine 1-phosphate receptor (S1PR)1 and S1PR4 and endothelial S1PR2 regulate afferent lymphatic migration. Sci Immunol. 2019 03 15; 4(33). PMID: 30877143.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  34. Swendeman SL, Hla T. Lipid Mediators, M2 Macrophages, and Pathological Neovascularization. Trends Mol Med. 2018 12; 24(12):977-978. PMID: 30448396; PMCID: PMC6876743.
    Citations:    Fields:    Translation:HumansAnimalsCells
  35. Burg N, Swendeman S, Worgall S, Hla T, Salmon JE. Sphingosine 1-Phosphate Receptor 1 Signaling Maintains Endothelial Cell Barrier Function and Protects Against Immune Complex-Induced Vascular Injury. Arthritis Rheumatol. 2018 11; 70(11):1879-1889. PMID: 29781582; PMCID: PMC6734184.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  36. Montrose DC, Zhou XK, McNally EM, Sue E, Wang H, Nishiguchi R, Verma A, Elemento O, Simpson KW, Yang P, Hla T, Dannenberg AJ. Colonoscopic-Guided Pinch Biopsies in Mice as a Useful Model for Evaluating the Roles of Host and Luminal Factors in Colonic Inflammation. Am J Pathol. 2018 12; 188(12):2811-2825. PMID: 30273600; PMCID: PMC6334259.
    Citations: 1     Fields:    Translation:AnimalsCells
  37. Hisano Y, Hla T. Bioactive lysolipids in cancer and angiogenesis. Pharmacol Ther. 2019 01; 193:91-98. PMID: 30048709; PMCID: PMC6309747.
    Citations: 33     Fields:    Translation:HumansAnimals
  38. Ghosh M, Thangada S, Dasgupta O, Khanna KM, Yamase HT, Kashgarian M, Hla T, Shapiro LH, Ferrer FA. Cell-intrinsic sphingosine kinase 2 promotes macrophage polarization and renal inflammation in response to unilateral ureteral obstruction. PLoS One. 2018; 13(3):e0194053. PMID: 29518138.
    Citations: 13     Fields:    Translation:AnimalsCells
  39. Yanagida K, Hla T. A dark side to omega-3 fatty acids. Nature. 2017 12 14; 552(7684):180-181. PMID: 29239390; PMCID: PMC6239194.
    Citations: 3     Fields:    Translation:Humans
  40. Yanagida K, Hla T. A dark side to omega-3 fatty acids. Nature. 2017 Dec; 552(7684):180-181. PMID: 32080455.
    Citations:    Fields:    
  41. Kono M, Conlon EG, Lux SY, Yanagida K, Hla T, Proia RL. Bioluminescence imaging of G protein-coupled receptor activation in living mice. Nat Commun. 2017 10 27; 8(1):1163. PMID: 29079828.
    Citations: 16     Fields:    Translation:AnimalsCells
  42. Mendelson K, Pandey S, Hisano Y, Carellini F, Das BC, Hla T, Evans T. The ceramide synthase 2b gene mediates genomic sensing and regulation of sphingosine levels during zebrafish embryogenesis. Elife. 2017 09 28; 6. PMID: 28956531.
    Citations: 5     Fields:    Translation:Animals
  43. Singh RK, Haka AS, Brumfield A, Grosheva I, Bhardwaj P, Chin HF, Xiong Y, Hla T, Maxfield FR. Ceramide activation of RhoA/Rho kinase impairs actin polymerization during aggregated LDL catabolism. J Lipid Res. 2017 10; 58(10):1977-1987. PMID: 28814641.
    Citations: 7     Fields:    Translation:AnimalsCells
  44. Swendeman SL, Xiong Y, Cantalupo A, Yuan H, Burg N, Hisano Y, Cartier A, Liu CH, Engelbrecht E, Blaho V, Zhang Y, Yanagida K, Galvani S, Obinata H, Salmon JE, Sanchez T, Di Lorenzo A, Hla T. An engineered S1P chaperone attenuates hypertension and ischemic injury. Sci Signal. 2017 Aug 15; 10(492). PMID: 28811382.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  45. Etemadi N, Chopin M, Anderton H, Tanzer MC, Rickard JA, Abeysekera W, Hall C, Spall SK, Wang B, Xiong Y, Hla T, Pitson SM, Bonder CS, Wong WW, Ernst M, Smyth GK, Vaux DL, Nutt SL, Nachbur U, Silke J. Correction: TRAF2 regulates TNF and NF-?B signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1. Elife. 2017 06 27; 6. PMID: 28654421.
    Citations: 2     Fields:    
  46. Cantalupo A, Gargiulo A, Dautaj E, Liu C, Zhang Y, Hla T, Di Lorenzo A. S1PR1 (Sphingosine-1-Phosphate Receptor 1) Signaling Regulates Blood Flow and Pressure. Hypertension. 2017 08; 70(2):426-434. PMID: 28607130.
    Citations: 33     Fields:    Translation:AnimalsCells
  47. Galvani S, Hla T. Quality Versus Quantity: Making HDL Great Again. Arterioscler Thromb Vasc Biol. 2017 06; 37(6):1018-1019. PMID: 28539490; PMCID: PMC5498076.
    Citations: 5     Fields:    Translation:Humans
  48. Mendoza A, Fang V, Chen C, Serasinghe M, Verma A, Muller J, Chaluvadi VS, Dustin ML, Hla T, Elemento O, Chipuk JE, Schwab SR. Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells. Nature. 2017 06 01; 546(7656):158-161. PMID: 28538737.
    Citations: 68     Fields:    Translation:AnimalsCells
  49. Yanagida K, Liu CH, Faraco G, Galvani S, Smith HK, Burg N, Anrather J, Sanchez T, Iadecola C, Hla T. Size-selective opening of the blood-brain barrier by targeting endothelial sphingosine 1-phosphate receptor 1. Proc Natl Acad Sci U S A. 2017 04 25; 114(17):4531-4536. PMID: 28396408; PMCID: PMC5410849.
    Citations: 78     Fields:    Translation:AnimalsCells
  50. Ding BS, Liu CH, Sun Y, Chen Y, Swendeman SL, Jung B, Chavez D, Cao Z, Christoffersen C, Nielsen LB, Schwab SR, Rafii S, Hla T. HDL activation of endothelial sphingosine-1-phosphate receptor-1 (S1P1) promotes regeneration and suppresses fibrosis in the liver. JCI Insight. 2016 Dec 22; 1(21):e87058. PMID: 28018969; PMCID: PMC5161208.
    Citations: 23     Fields:    
  51. Yanagida K, Hla T. Vascular and Immunobiology of the Circulatory Sphingosine 1-Phosphate Gradient. Annu Rev Physiol. 2017 02 10; 79:67-91. PMID: 27813829; PMCID: PMC5500220.
    Citations: 40     Fields:    Translation:HumansAnimals
  52. Gazit SL, Mariko B, Thérond P, Decouture B, Xiong Y, Couty L, Bonnin P, Baudrie V, Le Gall SM, Dizier B, Zoghdani N, Ransinan J, Hamilton JR, Gaussem P, Tharaux PL, Chun J, Coughlin SR, Bachelot-Loza C, Hla T, Ho-Tin-Noé B, Camerer E. Platelet and Erythrocyte Sources of S1P Are Redundant for Vascular Development and Homeostasis, but Both Rendered Essential After Plasma S1P Depletion in Anaphylactic Shock. Circ Res. 2016 Sep 30; 119(8):e110-26. PMID: 27582371; PMCID: PMC5064286.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  53. Xiong Y, Lee HJ, Mariko B, Lu YC, Dannenberg AJ, Haka AS, Maxfield FR, Camerer E, Proia RL, Hla T. Sphingosine kinases are not required for inflammatory responses in macrophages. J Biol Chem. 2016 May 20; 291(21):11465. PMID: 27226645; PMCID: PMC4900292.
    Citations: 4     Fields:    
  54. Christensen PM, Liu CH, Swendeman SL, Obinata H, Qvortrup K, Nielsen LB, Hla T, Di Lorenzo A, Christoffersen C. Impaired endothelial barrier function in apolipoprotein M-deficient mice is dependent on sphingosine-1-phosphate receptor 1. FASEB J. 2016 06; 30(6):2351-9. PMID: 26956418; PMCID: PMC4871798.
    Citations: 43     Fields:    Translation:Animals
  55. Etemadi N, Chopin M, Anderton H, Tanzer MC, Rickard JA, Abeysekera W, Hall C, Spall SK, Wang B, Xiong Y, Hla T, Pitson SM, Bonder CS, Wong WW, Ernst M, Smyth GK, Vaux DL, Nutt SL, Nachbur U, Silke J. TRAF2 regulates TNF and NF-?B signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1. Elife. 2015 Dec 23; 4. PMID: 26701909.
    Citations: 36     Fields:    Translation:AnimalsCells
  56. Wagschal A, Najafi-Shoushtari SH, Wang L, Goedeke L, Sinha S, deLemos AS, Black JC, Ramírez CM, Li Y, Tewhey R, Hatoum I, Shah N, Lu Y, Kristo F, Psychogios N, Vrbanac V, Lu YC, Hla T, de Cabo R, Tsang JS, Schadt E, Sabeti PC, Kathiresan S, Cohen DE, Whetstine J, Chung RT, Fernández-Hernando C, Kaplan LM, Bernards A, Gerszten RE, Näär AM. Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis. Nat Med. 2015 Nov; 21(11):1290-7. PMID: 26501192; PMCID: PMC4993048.
    Citations: 113     Fields:    Translation:HumansAnimals
  57. Cantalupo A, Zhang Y, Kothiya M, Galvani S, Obinata H, Bucci M, Giordano FJ, Jiang XC, Hla T, Di Lorenzo A. Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure. Nat Med. 2015 Sep; 21(9):1028-1037. PMID: 26301690; PMCID: PMC4692717.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  58. Galvani S, Sanson M, Blaho VA, Swendeman SL, Obinata H, Conger H, Dahlbäck B, Kono M, Proia RL, Smith JD, Hla T. HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1 to limit vascular inflammation. Sci Signal. 2015 Aug 11; 8(389):ra79. PMID: 26268607.
    Citations: 116     Fields:    Translation:HumansAnimalsCells
  59. Mendelson K, Lan Y, Hla T, Evans T. Maternal or zygotic sphingosine kinase is required to regulate zebrafish cardiogenesis. Dev Dyn. 2015 Aug; 244(8):948-54. PMID: 25997406; PMCID: PMC4520754.
    Citations: 7     Fields:    Translation:Animals
  60. Li MH, Swenson R, Harel M, Jana S, Stolarzewicz E, Hla T, Shapiro LH, Ferrer F. Antitumor Activity of a Novel Sphingosine-1-Phosphate 2 Antagonist, AB1, in Neuroblastoma. J Pharmacol Exp Ther. 2015 Sep; 354(3):261-8. PMID: 26105954; PMCID: PMC4538871.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  61. Blaho VA, Galvani S, Engelbrecht E, Liu C, Swendeman SL, Kono M, Proia RL, Steinman L, Han MH, Hla T. HDL-bound sphingosine-1-phosphate restrains lymphopoiesis and neuroinflammation. Nature. 2015 Jul 16; 523(7560):342-6. PMID: 26053123.
    Citations: 99     Fields:    Translation:AnimalsCells
  62. Proia RL, Hla T. Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy. J Clin Invest. 2015 Apr; 125(4):1379-87. PMID: 25831442; PMCID: PMC4409021.
    Citations: 220     Fields:    Translation:HumansAnimals
  63. Lu YC, Chang SH, Hafner M, Li X, Tuschl T, Elemento O, Hla T. ELAVL1 modulates transcriptome-wide miRNA binding in murine macrophages. Cell Rep. 2014 Dec 24; 9(6):2330-43. PMID: 25533351.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  64. Chang SH, Elemento O, Zhang J, Zhuang ZW, Simons M, Hla T. ELAVL1 regulates alternative splicing of eIF4E transporter to promote postnatal angiogenesis. Proc Natl Acad Sci U S A. 2014 Dec 23; 111(51):18309-14. PMID: 25422430; PMCID: PMC4280608.
    Citations: 30     Fields:    Translation:AnimalsCells
  65. Hla T, Kolesnick R. C16:0-ceramide signals insulin resistance. Cell Metab. 2014 Nov 04; 20(5):703-705. PMID: 25440051; PMCID: PMC4393079.
    Citations: 35     Fields:    Translation:HumansAnimals
  66. Obinata H, Gutkind S, Stitham J, Okuno T, Yokomizo T, Hwa J, Hla T. Individual variation of human S1P1 coding sequence leads to heterogeneity in receptor function and drug interactions. J Lipid Res. 2014 Dec; 55(12):2665-75. PMID: 25293589.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  67. Xiong Y, Yang P, Proia RL, Hla T. Erythrocyte-derived sphingosine 1-phosphate is essential for vascular development. J Clin Invest. 2014 Nov; 124(11):4823-8. PMID: 25250575; PMCID: PMC4347220.
    Citations: 47     Fields:    Translation:AnimalsCells
  68. Murakami K, Kohno M, Kadoya M, Nagahara H, Fujii W, Seno T, Yamamoto A, Oda R, Fujiwara H, Kubo T, Morita S, Nakada H, Hla T, Kawahito Y. Knock out of S1P3 receptor signaling attenuates inflammation and fibrosis in bleomycin-induced lung injury mice model. PLoS One. 2014; 9(9):e106792. PMID: 25198418.
    Citations: 21     Fields:    Translation:AnimalsCells
  69. Huang C, Gonzalez DG, Cote CM, Jiang Y, Hatzi K, Teater M, Dai K, Hla T, Haberman AM, Melnick A. The BCL6 RD2 domain governs commitment of activated B cells to form germinal centers. Cell Rep. 2014 Sep 11; 8(5):1497-508. PMID: 25176650.
    Citations: 26     Fields:    Translation:AnimalsCells
  70. Giammanco A, Blanc V, Montenegro G, Klos C, Xie Y, Kennedy S, Luo J, Chang SH, Hla T, Nalbantoglu I, Dharmarajan S, Davidson NO. Intestinal epithelial HuR modulates distinct pathways of proliferation and apoptosis and attenuates small intestinal and colonic tumor development. Cancer Res. 2014 Sep 15; 74(18):5322-35. PMID: 25085247.
    Citations: 29     Fields:    Translation:Animals
  71. Camm J, Hla T, Bakshi R, Brinkmann V. Cardiac and vascular effects of fingolimod: mechanistic basis and clinical implications. Am Heart J. 2014 Nov; 168(5):632-44. PMID: 25440790.
    Citations: 72     Fields:    Translation:HumansCells
  72. Garris CS, Blaho VA, Hla T, Han MH. Sphingosine-1-phosphate receptor 1 signalling in T cells: trafficking and beyond. Immunology. 2014 Jul; 142(3):347-53. PMID: 24597601.
    Citations: 65     Fields:    Translation:HumansAnimalsCells
  73. Li MH, Harel M, Hla T, Ferrer F. Induction of chemokine (C-C motif) ligand 2 by sphingosine-1-phosphate signaling in neuroblastoma. J Pediatr Surg. 2014 Aug; 49(8):1286-91. PMID: 25092091.
    Citations: 5     Fields:    Translation:HumansCells
  74. Chang SH, Hla T. Post-transcriptional gene regulation by HuR and microRNAs in angiogenesis. Curr Opin Hematol. 2014 May; 21(3):235-40. PMID: 24714527.
    Citations: 24     Fields:    Translation:Humans
  75. Thangada S, Shapiro LH, Silva C, Yamase H, Hla T, Ferrer FA. Treatment with the immunomodulator FTY720 (fingolimod) significantly reduces renal inflammation in murine unilateral ureteral obstruction. J Urol. 2014 May; 191(5 Suppl):1508-16. PMID: 24679864.
    Citations: 8     Fields:    Translation:Animals
  76. Blaho VA, Hla T. An update on the biology of sphingosine 1-phosphate receptors. J Lipid Res. 2014 Aug; 55(8):1596-608. PMID: 24459205.