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Timothy T Hla, Ph.D.

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Biography
2016
Fellow of the AAAS
2015
MD(honoris causa), Goethe University
2015
Outstanding achievement award
2014
Siegel award for outstanding medical research, Weill Cornell Medical College
2007
Honorary Member, Japanese Biochemical Society
2006
MERIT award, NHLBI, NIH
1999
Established Investigator, AHA
1988 - 1991
Postdoctoral fellowship award, Arthritis Foundation

Overview
Tim Hla's laboratory has been investigating the role of lipid mediators, sphingosine 1-phosphate (S1P) and prostanoids in vascular biology and disease. In the 1990s, we cloned the inducible cyclooxygenase (COX-2) and the first S1P receptor. Our work defined how the COX-2 pathway regulates angiogenesis, cancer and inflammatory disease. Recently, we are examining molecular mechanisms by which prostanoids interact with other lipid signaling systems to protect the vascular system and maintain health. Secondly, since our discovery of the S1P receptor, we have been working on how this novel signaling pathway regulates vascular development, homeostasis and is dysregulated in vascular diseases. In addition, our work contributed to the development of S1P receptor inhibitors, which are being used for the treatment of a number of autoimmune diseases. Recently, we discovered that HDL-bound S1P activates vascular S1P receptors to inhibit vascular injury and disease. We also showed that proteins that bind to S1P, such as the HDL-bound apolipoprotein M (ApoM), direct specific biological functions of S1P by activating S1P receptors in unique ways. This mode of signaling, termed as, chaperone-dependent S1P signaling, may be a general mechanism for lipid mediators that are poorly soluble in water. We are also examining novel mechanisms of S1P metabolism, export into the extracellular environment, capture and signaling by novel chaperones, receptor-dependent signaling mechanisms and cross-talk with other cytokine, growth factor signaling pathways. Such mechanistic information is useful not only to achieve a deeper understanding of vascular health and disease but also to develop new therapeutic entities. In fact, our laboratory is developing novel small molecules as well as protein biotherapeutics to modulate heart disease, stroke, autoimmune diseases, eye disease and cancer.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. 1R35HL135821 (Hla, Timothy) Jan 18, 2017 - Dec 31, 2023
    NIH/ NHLBI
    Mechanisms of sphingolipid signaling in vascular health and disease
    Role Description: Endothelial injury is a key event in cardiovascular disease, which is accelerated in autoimmune diseases such as systemic lupus erythematosus. This project will investigate a sphingosine 1-phosphate receptor on endothelial cells which is activated by normal blood flow as well as high density lipoproteins, with the aim of better understanding vascular diseases and to develop new therapies.
    Role: Pinciple Investigator
  2. R35HL135821 (HLA, TIMOTHY TUN) Jan 18, 2017 - Dec 31, 2023
    NIH/NHLBI
    Mechanisms of sphingolipid signaling in vascular health and disease
    Role: Principal Investigator
  3. Transatlantic Network Grant (Hla/ Betsholtz) Sep 1, 2014 - Aug 30, 2019
    Fondation Leducq
    Sphingolipid mediators in neurovascular biology and disease
    Role: Principle investigator
  4. P01CA077839 (DUBOIS, RAYMOND NELSON) Apr 7, 1999 - May 31, 2017
    NIH/NCI
    The Role of Bioactive Lipids in Inflammation and Cancer
    Role: Co-Investigator

Featured Content

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Engelbrecht E, Levesque MV, He L, Vanlandewijck M, Nitzsche A, Niazi H, Kuo A, Singh SA, Aikawa M, Holton K, Proia RL, Kono M, Pu WT, Camerer E, Betsholtz C, Hla T. Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta. Elife. 2020 Feb 24; 9. PMID: 32091396.
    Citations:    
  2. Yanagida K, Engelbrecht E, Niaudet C, Jung B, Gaengel K, Holton K, Swendeman S, Liu CH, Levesque MV, Kuo A, Fu Z, Smith LEH, Betsholtz C, Hla T. Sphingosine 1-Phosphate Receptor Signaling Establishes AP-1 Gradients to Allow for Retinal Endothelial Cell Specialization. Dev Cell. 2020 Mar 23; 52(6):779-793.e7. PMID: 32059774.
    Citations:    
  3. Cartier A, Leigh T, Liu CH, Hla T. Endothelial sphingosine 1-phosphate receptors promote vascular normalization and antitumor therapy. Proc Natl Acad Sci U S A. 2020 Feb 11; 117(6):3157-3166. PMID: 31988136.
    Citations:    
  4. Pandey S, Banks KM, Kumar R, Kuo A, Wen D, Hla T, Evans T. Sphingosine kinases protect murine embryonic stem cells from sphingosine-induced cell cycle arrest. Stem Cells. 2020 Jan 09. PMID: 31916656.
    Citations:    
  5. Subbaramaiah K, Hudis C, Chang SH, Hla T, Dannenberg AJ. Withdrawal: EP2 and EP4 receptors regulate aromatase expression in human adipocytes and breast cancer cells: Evidence of a BRCA1 and p300 exchange. J Biol Chem. 2020 01 03; 295(1):295. PMID: 31900377.
    Citations:    
  6. Poganik JR, Long MJC, Disare MT, Liu X, Chang SH, Hla T, Aye Y. Post-transcriptional regulation of Nrf2-mRNA by the mRNA-binding proteins HuR and AUF1. FASEB J. 2019 Dec; 33(12):14636-14652. PMID: 31665914.
    Citations:    
  7. Cartier A, Hla T. Sphingosine 1-phosphate: Lipid signaling in pathology and therapy. Science. 2019 10 18; 366(6463). PMID: 31624181.
    Citations:    
  8. Singh RK, Haka AS, Asmal A, Barbosa-Lorenzi VC, Grosheva I, Chin HF, Xiong Y, Hla T, Maxfield FR. TLR4 (Toll-Like Receptor 4)-Dependent Signaling Drives Extracellular Catabolism of LDL (Low-Density Lipoprotein) Aggregates. Arterioscler Thromb Vasc Biol. 2020 Jan; 40(1):86-102. PMID: 31597445.
    Citations:    
  9. Obinata H, Kuo A, Wada Y, Swendeman S, Liu CH, Blaho VA, Nagumo R, Satoh K, Izumi T, Hla T. Identification of ApoA4 as a sphingosine 1-phosphate chaperone in ApoM- and albumin-deficient mice. J Lipid Res. 2019 Nov; 60(11):1912-1921. PMID: 31462513.
    Citations:    
  10. Obinata H, Hla T. Sphingosine 1-phosphate and inflammation. Int Immunol. 2019 08 23; 31(9):617-625. PMID: 31049553.
    Citations:    
  11. Tsai HC, Nguyen K, Hashemi E, Engleman E, Hla T, Han MH. Myeloid sphingosine-1-phosphate receptor 1 is important for CNS autoimmunity and neuroinflammation. J Autoimmun. 2019 Dec; 105:102290. PMID: 31202617.
    Citations:    
  12. Inoue T, Kohno M, Nagahara H, Murakami K, Sagawa T, Kasahara A, Kaneshita S, Kida T, Fujioka K, Wada M, Nakada H, Hla T, Kawahito Y. Upregulation of sphingosine-1-phosphate receptor 3 on fibroblast-like synoviocytes is associated with the development of collagen-induced arthritis via increased interleukin-6 production. PLoS One. 2019; 14(6):e0218090. PMID: 31173610.
    Citations:    
  13. Hisano Y, Kono M, Cartier A, Engelbrecht E, Kano K, Kawakami K, Xiong Y, Piao W, Galvani S, Yanagida K, Kuo A, Ono Y, Ishida S, Aoki J, Proia RL, Bromberg JS, Inoue A, Hla T. Lysolipid receptor cross-talk regulates lymphatic endothelial junctions in lymph nodes. J Exp Med. 2019 Jul 01; 216(7):1582-1598. PMID: 31147448.
    Citations:    
  14. Shi X, Wang W, Li J, Wang T, Lin Y, Huang S, Kuver A, Chen C, Hla T, Li X, Dai K. Sphingosine 1-phosphate receptor 1 regulates cell-surface localization of membrane proteins in endothelial cells. Biochim Biophys Acta Gen Subj. 2019 06; 1863(6):1079-1087. PMID: 30954526.
    Citations:    
  15. Ban Y, Dong W, Zhang L, Zhou T, Altiti AS, Ali K, Mootoo DR, Blaho VA, Hla T, Ren Y, Ma X. Abrogation of Endogenous Glycolipid Antigen Presentation on Myelin-Laden Macrophages by D-Sphingosine Ameliorates the Pathogenesis of Experimental Autoimmune Encephalomyelitis. Front Immunol. 2019; 10:404. PMID: 30941120.
    Citations:    
  16. Xiong Y, Piao W, Brinkman CC, Li L, Kulinski JM, Olivera A, Cartier A, Hla T, Hippen KL, Blazar BR, Schwab SR, Bromberg JS. CD4 T cell sphingosine 1-phosphate receptor (S1PR)1 and S1PR4 and endothelial S1PR2 regulate afferent lymphatic migration. Sci Immunol. 2019 03 15; 4(33). PMID: 30877143.
    Citations:    
  17. Swendeman SL, Hla T. Lipid Mediators, M2 Macrophages, and Pathological Neovascularization. Trends Mol Med. 2018 12; 24(12):977-978. PMID: 30448396.
    Citations:    Fields:    
  18. Burg N, Swendeman S, Worgall S, Hla T, Salmon JE. Sphingosine 1-Phosphate Receptor 1 Signaling Maintains Endothelial Cell Barrier Function and Protects Against Immune Complex-Induced Vascular Injury. Arthritis Rheumatol. 2018 11; 70(11):1879-1889. PMID: 29781582.
    Citations:    Fields:    
  19. Montrose DC, Zhou XK, McNally EM, Sue E, Wang H, Nishiguchi R, Verma A, Elemento O, Simpson KW, Yang P, Hla T, Dannenberg AJ. Colonoscopic-Guided Pinch Biopsies in Mice as a Useful Model for Evaluating the Roles of Host and Luminal Factors in Colonic Inflammation. Am J Pathol. 2018 12; 188(12):2811-2825. PMID: 30273600.
    Citations:    Fields:    
  20. Hisano Y, Hla T. Bioactive lysolipids in cancer and angiogenesis. Pharmacol Ther. 2019 01; 193:91-98. PMID: 30048709.
    Citations:    Fields:    
  21. Ghosh M, Thangada S, Dasgupta O, Khanna KM, Yamase HT, Kashgarian M, Hla T, Shapiro LH, Ferrer FA. Cell-intrinsic sphingosine kinase 2 promotes macrophage polarization and renal inflammation in response to unilateral ureteral obstruction. PLoS One. 2018; 13(3):e0194053. PMID: 29518138.
    Citations: 1     Fields:    Translation:AnimalsCells
  22. Yanagida K, Hla T. A dark side to omega-3 fatty acids. Nature. 2017 12 14; 552(7684):180-181. PMID: 29239390.
    Citations:    Fields:    Translation:Humans
  23. Yanagida K, Hla T. A dark side to omega-3 fatty acids. Nature. 2017 Dec; 552(7684):180-181. PMID: 32080455.
    Citations:    
  24. Kono M, Conlon EG, Lux SY, Yanagida K, Hla T, Proia RL. Bioluminescence imaging of G protein-coupled receptor activation in living mice. Nat Commun. 2017 10 27; 8(1):1163. PMID: 29079828.
    Citations: 1     Fields:    Translation:AnimalsCells
  25. Mendelson K, Pandey S, Hisano Y, Carellini F, Das BC, Hla T, Evans T. The ceramide synthase 2b gene mediates genomic sensing and regulation of sphingosine levels during zebrafish embryogenesis. Elife. 2017 09 28; 6. PMID: 28956531.
    Citations: 1     Fields:    Translation:Animals
  26. Singh RK, Haka AS, Brumfield A, Grosheva I, Bhardwaj P, Chin HF, Xiong Y, Hla T, Maxfield FR. Ceramide activation of RhoA/Rho kinase impairs actin polymerization during aggregated LDL catabolism. J Lipid Res. 2017 10; 58(10):1977-1987. PMID: 28814641.
    Citations:    Fields:    Translation:AnimalsCells
  27. Swendeman SL, Xiong Y, Cantalupo A, Yuan H, Burg N, Hisano Y, Cartier A, Liu CH, Engelbrecht E, Blaho V, Zhang Y, Yanagida K, Galvani S, Obinata H, Salmon JE, Sanchez T, Di Lorenzo A, Hla T. An engineered S1P chaperone attenuates hypertension and ischemic injury. Sci Signal. 2017 Aug 15; 10(492). PMID: 28811382.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  28. Etemadi N, Chopin M, Anderton H, Tanzer MC, Rickard JA, Abeysekera W, Hall C, Spall SK, Wang B, Xiong Y, Hla T, Pitson SM, Bonder CS, Wong WW, Ernst M, Smyth GK, Vaux DL, Nutt SL, Nachbur U, Silke J. Correction: TRAF2 regulates TNF and NF-?B signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1. Elife. 2017 06 27; 6. PMID: 28654421.
    Citations: 1     Fields:    
  29. Cantalupo A, Gargiulo A, Dautaj E, Liu C, Zhang Y, Hla T, Di Lorenzo A. S1PR1 (Sphingosine-1-Phosphate Receptor 1) Signaling Regulates Blood Flow and Pressure. Hypertension. 2017 08; 70(2):426-434. PMID: 28607130.
    Citations: 1     Fields:    Translation:AnimalsCells
  30. Galvani S, Hla T. Quality Versus Quantity: Making HDL Great Again. Arterioscler Thromb Vasc Biol. 2017 06; 37(6):1018-1019. PMID: 28539490.
    Citations: 1     Fields:    
  31. Mendoza A, Fang V, Chen C, Serasinghe M, Verma A, Muller J, Chaluvadi VS, Dustin ML, Hla T, Elemento O, Chipuk JE, Schwab SR. Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells. Nature. 2017 06 01; 546(7656):158-161. PMID: 28538737.
    Citations: 11     Fields:    Translation:AnimalsCells
  32. Yanagida K, Liu CH, Faraco G, Galvani S, Smith HK, Burg N, Anrather J, Sanchez T, Iadecola C, Hla T. Size-selective opening of the blood-brain barrier by targeting endothelial sphingosine 1-phosphate receptor 1. Proc Natl Acad Sci U S A. 2017 04 25; 114(17):4531-4536. PMID: 28396408.
    Citations: 4     Fields:    Translation:AnimalsCells
  33. Ding BS, Liu CH, Sun Y, Chen Y, Swendeman SL, Jung B, Chavez D, Cao Z, Christoffersen C, Nielsen LB, Schwab SR, Rafii S, Hla T. HDL activation of endothelial sphingosine-1-phosphate receptor-1 (S1P1) promotes regeneration and suppresses fibrosis in the liver. JCI Insight. 2016 Dec 22; 1(21):e87058. PMID: 28018969.
    Citations: 8     Fields:    
  34. Yanagida K, Hla T. Vascular and Immunobiology of the Circulatory Sphingosine 1-Phosphate Gradient. Annu Rev Physiol. 2017 02 10; 79:67-91. PMID: 27813829.
    Citations: 8     Fields:    Translation:HumansAnimals
  35. Gazit SL, Mariko B, Thérond P, Decouture B, Xiong Y, Couty L, Bonnin P, Baudrie V, Le Gall SM, Dizier B, Zoghdani N, Ransinan J, Hamilton JR, Gaussem P, Tharaux PL, Chun J, Coughlin SR, Bachelot-Loza C, Hla T, Ho-Tin-Noé B, Camerer E. Platelet and Erythrocyte Sources of S1P Are Redundant for Vascular Development and Homeostasis, but Both Rendered Essential After Plasma S1P Depletion in Anaphylactic Shock. Circ Res. 2016 Sep 30; 119(8):e110-26. PMID: 27582371.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  36. Xiong Y, Lee HJ, Mariko B, Lu YC, Dannenberg AJ, Haka AS, Maxfield FR, Camerer E, Proia RL, Hla T. Sphingosine kinases are not required for inflammatory responses in macrophages. J Biol Chem. 2016 May 20; 291(21):11465. PMID: 27226645.
    Citations: 2     Fields:    
  37. Christensen PM, Liu CH, Swendeman SL, Obinata H, Qvortrup K, Nielsen LB, Hla T, Di Lorenzo A, Christoffersen C. Impaired endothelial barrier function in apolipoprotein M-deficient mice is dependent on sphingosine-1-phosphate receptor 1. FASEB J. 2016 06; 30(6):2351-9. PMID: 26956418.
    Citations: 9     Fields:    Translation:Animals
  38. Etemadi N, Chopin M, Anderton H, Tanzer MC, Rickard JA, Abeysekera W, Hall C, Spall SK, Wang B, Xiong Y, Hla T, Pitson SM, Bonder CS, Wong WW, Ernst M, Smyth GK, Vaux DL, Nutt SL, Nachbur U, Silke J. TRAF2 regulates TNF and NF-?B signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1. Elife. 2015 Dec 23; 4. PMID: 26701909.
    Citations: 15     Fields:    Translation:AnimalsCells
  39. Wagschal A, Najafi-Shoushtari SH, Wang L, Goedeke L, Sinha S, deLemos AS, Black JC, Ramírez CM, Li Y, Tewhey R, Hatoum I, Shah N, Lu Y, Kristo F, Psychogios N, Vrbanac V, Lu YC, Hla T, de Cabo R, Tsang JS, Schadt E, Sabeti PC, Kathiresan S, Cohen DE, Whetstine J, Chung RT, Fernández-Hernando C, Kaplan LM, Bernards A, Gerszten RE, Näär AM. Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis. Nat Med. 2015 Nov; 21(11):1290-7. PMID: 26501192.
    Citations: 36     Fields:    Translation:HumansAnimals
  40. Cantalupo A, Zhang Y, Kothiya M, Galvani S, Obinata H, Bucci M, Giordano FJ, Jiang XC, Hla T, Di Lorenzo A. Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure. Nat Med. 2015 Sep; 21(9):1028-1037. PMID: 26301690.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  41. Galvani S, Sanson M, Blaho VA, Swendeman SL, Obinata H, Conger H, Dahlbäck B, Kono M, Proia RL, Smith JD, Hla T. HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1 to limit vascular inflammation. Sci Signal. 2015 Aug 11; 8(389):ra79. PMID: 26268607.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  42. Mendelson K, Lan Y, Hla T, Evans T. Maternal or zygotic sphingosine kinase is required to regulate zebrafish cardiogenesis. Dev Dyn. 2015 Aug; 244(8):948-54. PMID: 25997406.
    Citations: 3     Fields:    Translation:Animals
  43. Li MH, Swenson R, Harel M, Jana S, Stolarzewicz E, Hla T, Shapiro LH, Ferrer F. Antitumor Activity of a Novel Sphingosine-1-Phosphate 2 Antagonist, AB1, in Neuroblastoma. J Pharmacol Exp Ther. 2015 Sep; 354(3):261-8. PMID: 26105954.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  44. Blaho VA, Galvani S, Engelbrecht E, Liu C, Swendeman SL, Kono M, Proia RL, Steinman L, Han MH, Hla T. HDL-bound sphingosine-1-phosphate restrains lymphopoiesis and neuroinflammation. Nature. 2015 Jul 16; 523(7560):342-6. PMID: 26053123.
    Citations: 31     Fields:    Translation:AnimalsCells
  45. Proia RL, Hla T. Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy. J Clin Invest. 2015 Apr; 125(4):1379-87. PMID: 25831442.
    Citations: 75     Fields:    Translation:HumansAnimals
  46. Lu YC, Chang SH, Hafner M, Li X, Tuschl T, Elemento O, Hla T. ELAVL1 modulates transcriptome-wide miRNA binding in murine macrophages. Cell Rep. 2014 Dec 24; 9(6):2330-43. PMID: 25533351.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  47. Chang SH, Elemento O, Zhang J, Zhuang ZW, Simons M, Hla T. ELAVL1 regulates alternative splicing of eIF4E transporter to promote postnatal angiogenesis. Proc Natl Acad Sci U S A. 2014 Dec 23; 111(51):18309-14. PMID: 25422430.
    Citations: 7     Fields:    Translation:AnimalsCells
  48. Hla T, Kolesnick R. C16:0-ceramide signals insulin resistance. Cell Metab. 2014 Nov 04; 20(5):703-705. PMID: 25440051.
    Citations: 15     Fields:    Translation:HumansAnimals
  49. Obinata H, Gutkind S, Stitham J, Okuno T, Yokomizo T, Hwa J, Hla T. Individual variation of human S1P1 coding sequence leads to heterogeneity in receptor function and drug interactions. J Lipid Res. 2014 Dec; 55(12):2665-75. PMID: 25293589.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  50. Xiong Y, Yang P, Proia RL, Hla T. Erythrocyte-derived sphingosine 1-phosphate is essential for vascular development. J Clin Invest. 2014 Nov; 124(11):4823-8. PMID: 25250575.
    Citations: 18     Fields:    Translation:AnimalsCells
  51. Murakami K, Kohno M, Kadoya M, Nagahara H, Fujii W, Seno T, Yamamoto A, Oda R, Fujiwara H, Kubo T, Morita S, Nakada H, Hla T, Kawahito Y. Knock out of S1P3 receptor signaling attenuates inflammation and fibrosis in bleomycin-induced lung injury mice model. PLoS One. 2014; 9(9):e106792. PMID: 25198418.
    Citations: 5     Fields:    Translation:AnimalsCells
  52. Huang C, Gonzalez DG, Cote CM, Jiang Y, Hatzi K, Teater M, Dai K, Hla T, Haberman AM, Melnick A. The BCL6 RD2 domain governs commitment of activated B cells to form germinal centers. Cell Rep. 2014 Sep 11; 8(5):1497-508. PMID: 25176650.
    Citations: 11     Fields:    Translation:AnimalsCells
  53. Giammanco A, Blanc V, Montenegro G, Klos C, Xie Y, Kennedy S, Luo J, Chang SH, Hla T, Nalbantoglu I, Dharmarajan S, Davidson NO. Intestinal epithelial HuR modulates distinct pathways of proliferation and apoptosis and attenuates small intestinal and colonic tumor development. Cancer Res. 2014 Sep 15; 74(18):5322-35. PMID: 25085247.
    Citations: 9     Fields:    Translation:Animals
  54. Camm J, Hla T, Bakshi R, Brinkmann V. Cardiac and vascular effects of fingolimod: mechanistic basis and clinical implications. Am Heart J. 2014 Nov; 168(5):632-44. PMID: 25440790.
    Citations: 30     Fields:    Translation:HumansCells
  55. Garris CS, Blaho VA, Hla T, Han MH. Sphingosine-1-phosphate receptor 1 signalling in T cells: trafficking and beyond. Immunology. 2014 Jul; 142(3):347-53. PMID: 24597601.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  56. Li MH, Harel M, Hla T, Ferrer F. Induction of chemokine (C-C motif) ligand 2 by sphingosine-1-phosphate signaling in neuroblastoma. J Pediatr Surg. 2014 Aug; 49(8):1286-91. PMID: 25092091.
    Citations: 2     Fields:    Translation:HumansCells
  57. Chang SH, Hla T. Post-transcriptional gene regulation by HuR and microRNAs in angiogenesis. Curr Opin Hematol. 2014 May; 21(3):235-40. PMID: 24714527.
    Citations: 14     Fields:    Translation:Humans
  58. Thangada S, Shapiro LH, Silva C, Yamase H, Hla T, Ferrer FA. Treatment with the immunomodulator FTY720 (fingolimod) significantly reduces renal inflammation in murine unilateral ureteral obstruction. J Urol. 2014 May; 191(5 Suppl):1508-16. PMID: 24679864.
    Citations: 4     Fields:    Translation:Animals
  59. Blaho VA, Hla T. An update on the biology of sphingosine 1-phosphate receptors. J Lipid Res. 2014 Aug; 55(8):1596-608. PMID: 24459205.
    Citations: 75     Fields:    Translation:HumansAnimalsCells
  60. Li X, Lu YC, Dai K, Torregroza I, Hla T, Evans T. Elavl1a regulates zebrafish erythropoiesis via posttranscriptional control of gata1. Blood. 2014 Feb 27; 123(9):1384-92. PMID: 24425803.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  61. Xiong Y, Hla T. S1P control of endothelial integrity. Curr Top Microbiol Immunol. 2014; 378:85-105. PMID: 24728594.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  62. Mendelson K, Evans T, Hla T. Sphingosine 1-phosphate signalling. Development. 2014 Jan; 141(1):5-9. PMID: 24346695.
    Citations: 46     Fields:    Translation:HumansCells
  63. Xiong Y, Lee HJ, Mariko B, Lu YC, Dannenberg AJ, Haka AS, Maxfield FR, Camerer E, Proia RL, Hla T. Sphingosine kinases are not required for inflammatory responses in macrophages. J Biol Chem. 2013 Nov 08; 288(45):32563-73. PMID: 24081141.
    Citations: 24     Fields:    Translation:AnimalsCells
  64. Garris CS, Wu L, Acharya S, Arac A, Blaho VA, Huang Y, Moon BS, Axtell RC, Ho PP, Steinberg GK, Lewis DB, Sobel RA, Han DK, Steinman L, Snyder MP, Hla T, Han MH. Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation. Nat Immunol. 2013 Nov; 14(11):1166-72. PMID: 24076635.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  65. Li MH, Hla T, Ferrer F. FTY720 inhibits tumor growth and enhances the tumor-suppressive effect of topotecan in neuroblastoma by interfering with the sphingolipid signaling pathway. Pediatr Blood Cancer. 2013 Sep; 60(9):1418-23. PMID: 23704073.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  66. Howe LR, Subbaramaiah K, Kent CV, Zhou XK, Chang SH, Hla T, Jakobsson PJ, Hudis CA, Dannenberg AJ. Genetic deletion of microsomal prostaglandin E synthase-1 suppresses mouse mammary tumor growth and angiogenesis. Prostaglandins Other Lipid Mediat. 2013 Oct; 106:99-105. PMID: 23624019.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  67. Montrose DC, Scherl EJ, Bosworth BP, Zhou XK, Jung B, Dannenberg AJ, Hla T. S1P1 localizes to the colonic vasculature in ulcerative colitis and maintains blood vessel integrity. J Lipid Res. 2013 Mar; 54(3):843-51. PMID: 23296878.
    Citations: 12     Fields:    Translation:HumansAnimals
  68. Mendelson K, Zygmunt T, Torres-Vázquez J, Evans T, Hla T. Sphingosine 1-phosphate receptor signaling regulates proper embryonic vascular patterning. J Biol Chem. 2013 Jan 25; 288(4):2143-56. PMID: 23229546.
    Citations: 21     Fields:    Translation:AnimalsCells
  69. Chang SH, Lu YC, Li X, Hsieh WY, Xiong Y, Ghosh M, Evans T, Elemento O, Hla T. Antagonistic function of the RNA-binding protein HuR and miR-200b in post-transcriptional regulation of vascular endothelial growth factor-A expression and angiogenesis. J Biol Chem. 2013 Feb 15; 288(7):4908-21. PMID: 23223443.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  70. Hla T, Galvani S, Rafii S, Nachman R. S1P and the birth of platelets. J Exp Med. 2012 Nov 19; 209(12):2137-40. PMID: 23166370.
    Citations: 6     Fields:    Translation:Cells
  71. Torregroza I, Holtzinger A, Mendelson K, Liu TC, Hla T, Evans T. Regulation of a vascular plexus by gata4 is mediated in zebrafish through the chemokine sdf1a. PLoS One. 2012; 7(10):e46844. PMID: 23056483.
    Citations: 4     Fields:    Translation:AnimalsCells
  72. Obinata H, Hla T. Fine-tuning S1P therapeutics. Chem Biol. 2012 Sep 21; 19(9):1080-2. PMID: 22999874.
    Citations: 6     Fields:    
  73. Hla T, Dannenberg AJ. Sphingolipid signaling in metabolic disorders. Cell Metab. 2012 Oct 03; 16(4):420-34. PMID: 22982021.
    Citations: 44     Fields:    Translation:HumansCells
  74. Jung B, Obinata H, Galvani S, Mendelson K, Ding BS, Skoura A, Kinzel B, Brinkmann V, Rafii S, Evans T, Hla T. Flow-regulated endothelial S1P receptor-1 signaling sustains vascular development. Dev Cell. 2012 Sep 11; 23(3):600-10. PMID: 22975328.
    Citations: 71     Fields:    Translation:AnimalsCells
  75. Takeshita H, Kitano M, Iwasaki T, Kitano S, Tsunemi S, Sato C, Sekiguchi M, Azuma N, Miyazawa K, Hla T, Sano H. Sphingosine 1-phosphate (S1P)/S1P receptor 1 signaling regulates receptor activator of NF-?B ligand (RANKL) expression in rheumatoid arthritis. Biochem Biophys Res Commun. 2012 Mar 09; 419(2):154-9. PMID: 22326262.
    Citations: 9     Fields:    Translation:HumansCells
  76. Moolenaar WH, Hla T. SnapShot: Bioactive lysophospholipids. Cell. 2012 Jan 20; 148(1-2):378-378.e2. PMID: 22265422.
    Citations: 11     Fields:    Translation:HumansAnimals
  77. Obinata H, Hla T. Assessment of sphingosine-1-phosphate activity in biological samples by receptor internalization and adherens junction formation. Methods Mol Biol. 2012; 874:69-76. PMID: 22528440.
    Citations: 3     Fields:    Translation:HumansCells
  78. Blaho VA, Hla T. Regulation of mammalian physiology, development, and disease by the sphingosine 1-phosphate and lysophosphatidic acid receptors. Chem Rev. 2011 Oct 12; 111(10):6299-320. PMID: 21939239.
    Citations: 50     Fields:    Translation:Animals
  79. Obinata H, Hla T. Sphingosine 1-phosphate in coagulation and inflammation. Semin Immunopathol. 2012 Jan; 34(1):73-91. PMID: 21805322.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  80. Chang SH, Hla T. Gene regulation by RNA binding proteins and microRNAs in angiogenesis. Trends Mol Med. 2011 Nov; 17(11):650-8. PMID: 21802991.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  81. Christoffersen C, Obinata H, Kumaraswamy SB, Galvani S, Ahnström J, Sevvana M, Egerer-Sieber C, Muller YA, Hla T, Nielsen LB, Dahlbäck B. Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M. Proc Natl Acad Sci U S A. 2011 Jun 07; 108(23):9613-8. PMID: 21606363.
    Citations: 124     Fields:    Translation:HumansAnimalsCells
  82. Li MH, Hla T, Ferrer F. Sphingolipid modulation of angiogenic factor expression in neuroblastoma. Cancer Prev Res (Phila). 2011 Aug; 4(8):1325-32. PMID: 21576349.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  83. Oo ML, Chang SH, Thangada S, Wu MT, Rezaul K, Blaho V, Hwang SI, Han DK, Hla T. Engagement of S1P1-degradative mechanisms leads to vascular leak in mice. J Clin Invest. 2011 Jun; 121(6):2290-300. PMID: 21555855.
    Citations: 62     Fields:    Translation:AnimalsCells
  84. Subbaramaiah K, Howe LR, Bhardwaj P, Du B, Gravaghi C, Yantiss RK, Zhou XK, Blaho VA, Hla T, Yang P, Kopelovich L, Hudis CA, Dannenberg AJ. Obesity is associated with inflammation and elevated aromatase expression in the mouse mammary gland. Cancer Prev Res (Phila). 2011 Mar; 4(3):329-46. PMID: 21372033.
    Citations: 129     Fields:    Translation:HumansAnimalsCells
  85. Hla T, Brinkmann V. Sphingosine 1-phosphate (S1P): Physiology and the effects of S1P receptor modulation. Neurology. 2011 Feb 22; 76(8 Suppl 3):S3-8. PMID: 21339489.
    Citations: 64     Fields:    Translation:HumansAnimals
  86. Chun J, Hla T, Lynch KR, Spiegel S, Moolenaar WH. International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature. Pharmacol Rev. 2010 Dec; 62(4):579-87. PMID: 21079037.
    Citations: 81     Fields:    Translation:HumansAnimals
  87. Skoura A, Michaud J, Im DS, Thangada S, Xiong Y, Smith JD, Hla T. Sphingosine-1-phosphate receptor-2 function in myeloid cells regulates vascular inflammation and atherosclerosis. Arterioscler Thromb Vasc Biol. 2011 Jan; 31(1):81-5. PMID: 20947824.
    Citations: 44     Fields:    Translation:AnimalsCells
  88. Thangada S, Khanna KM, Blaho VA, Oo ML, Im DS, Guo C, Lefrancois L, Hla T. Cell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics. J Exp Med. 2010 Jul 05; 207(7):1475-83. PMID: 20584883.
    Citations: 62     Fields:    Translation:AnimalsCells
  89. Habrukowich C, Han DK, Le A, Rezaul K, Pan W, Ghosh M, Li Z, Dodge-Kafka K, Jiang X, Bittman R, Hla T. Sphingosine interaction with acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) regulates PP2A activity and cyclooxygenase (COX)-2 expression in human endothelial cells. J Biol Chem. 2010 Aug 27; 285(35):26825-31. PMID: 20558741.
    Citations: 17     Fields:    Translation:HumansCells
  90. Michaud J, Im DS, Hla T. Inhibitory role of sphingosine 1-phosphate receptor 2 in macrophage recruitment during inflammation. J Immunol. 2010 Feb 01; 184(3):1475-83. PMID: 20042570.
    Citations: 47     Fields:    Translation:AnimalsCells
  91. Hla T, Oo ML. Ramping up RANTES in the acute response to arterial injury. J Clin Invest. 2010 Jan; 120(1):90-2. PMID: 20038805.
    Citations: 2     Fields:    Translation:AnimalsCells
  92. Ghosh M, Aguila HL, Michaud J, Ai Y, Wu MT, Hemmes A, Ristimaki A, Guo C, Furneaux H, Hla T. Essential role of the RNA-binding protein HuR in progenitor cell survival in mice. J Clin Invest. 2009 Dec; 119(12):3530-43. PMID: 19884656.
    Citations: 62     Fields:    Translation:AnimalsCells
  93. Hla T. Plugging vascular leak by sphingosine kinase from bone marrow progenitor cells. Circ Res. 2009 Sep 25; 105(7):614-6. PMID: 19797192.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  94. ter Braak M, Danneberg K, Lichte K, Liphardt K, Ktistakis NT, Pitson SM, Hla T, Jakobs KH, Meyer zu Heringdorf D. Galpha(q)-mediated plasma membrane translocation of sphingosine kinase-1 and cross-activation of S1P receptors. Biochim Biophys Acta. 2009 May; 1791(5):357-70. PMID: 19830907.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  95. Skoura A, Hla T. Regulation of vascular physiology and pathology by the S1P2 receptor subtype. Cardiovasc Res. 2009 May 01; 82(2):221-8. PMID: 19287048.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  96. Hla T, Im DS. Cell biology. The ABCs of lipophile transport. Science. 2009 Feb 13; 323(5916):883-4. PMID: 19213902.
    Citations: 2     Fields:    Translation:AnimalsCells
  97. Li MH, Sanchez T, Milne GL, Morrow JD, Hla T, Ferrer F. S1P/S1P2 signaling induces cyclooxygenase-2 expression in Wilms tumor. J Urol. 2009 Mar; 181(3):1347-52. PMID: 19157443.
    Citations: 12     Fields:    Translation:HumansCells
  98. Li MH, Sanchez T, Yamase H, Hla T, Oo ML, Pappalardo A, Lynch KR, Lin CY, Ferrer F. S1P/S1P1 signaling stimulates cell migration and invasion in Wilms tumor. Cancer Lett. 2009 Apr 18; 276(2):171-9. PMID: 19131156.
    Citations: 24     Fields:    Translation:HumansCells
  99. Ghosh M, Ai Y, Narko K, Wang Z, Peters JM, Hla T. PPARdelta is pro-tumorigenic in a mouse model of COX-2-induced mammary cancer. Prostaglandins Other Lipid Mediat. 2009 Apr; 88(3-4):97-100. PMID: 19101649.
    Citations: 13     Fields:    Translation:Animals
  100. Skoura A, Hla T. Lysophospholipid receptors in vertebrate development, physiology, and pathology. J Lipid Res. 2009 Apr; 50 Suppl:S293-8. PMID: 19065000.
    Citations: 32     Fields:    Translation:HumansAnimals
  101. Li MH, Sanchez T, Pappalardo A, Lynch KR, Hla T, Ferrer F. Induction of antiproliferative connective tissue growth factor expression in Wilms' tumor cells by sphingosine-1-phosphate receptor 2. Mol Cancer Res. 2008 Oct; 6(10):1649-56. PMID: 18922980.
    Citations: 22     Fields:    Translation:HumansCells
  102. Estrada R, Zeng Q, Lu H, Sarojini H, Lee JF, Mathis SP, Sanchez T, Wang E, Kontos CD, Lin CY, Hla T, Haribabu B, Lee MJ. Up-regulating sphingosine 1-phosphate receptor-2 signaling impairs chemotactic, wound-healing, and morphogenetic responses in senescent endothelial cells. J Biol Chem. 2008 Oct 31; 283(44):30363-75. PMID: 18765664.
    Citations: 24     Fields:    Translation:HumansCells
  103. Hla T, Venkataraman K, Michaud J. The vascular S1P gradient-cellular sources and biological significance. Biochim Biophys Acta. 2008 Sep; 1781(9):477-82. PMID: 18674637.
    Citations: 63     Fields:    Translation:HumansAnimals
  104. Venkataraman K, Lee YM, Michaud J, Thangada S, Ai Y, Bonkovsky HL, Parikh NS, Habrukowich C, Hla T. Vascular endothelium as a contributor of plasma sphingosine 1-phosphate. Circ Res. 2008 Mar 28; 102(6):669-76. PMID: 18258856.
    Citations: 153     Fields:    Translation:HumansAnimalsCells
  105. Sekiguchi M, Iwasaki T, Kitano M, Kuno H, Hashimoto N, Kawahito Y, Azuma M, Hla T, Sano H. Role of sphingosine 1-phosphate in the pathogenesis of Sjögren's syndrome. J Immunol. 2008 Feb 01; 180(3):1921-8. PMID: 18209090.
    Citations: 9     Fields:    Translation:HumansCells
  106. Wang Z, Liu B, Wang P, Dong X, Fernandez-Hernando C, Li Z, Hla T, Li Z, Claffey K, Smith JD, Wu D. Phospholipase C beta3 deficiency leads to macrophage hypersensitivity to apoptotic induction and reduction of atherosclerosis in mice. J Clin Invest. 2008 Jan; 118(1):195-204. PMID: 18079968.
    Citations: 24     Fields:    Translation:AnimalsCells
  107. Subbaramaiah K, Hudis C, Chang SH, Hla T, Dannenberg AJ. EP2 and EP4 receptors regulate aromatase expression in human adipocytes and breast cancer cells. Evidence of a BRCA1 and p300 exchange. J Biol Chem. 2008 Feb 08; 283(6):3433-44. PMID: 18083712.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  108. Skoura A, Sanchez T, Claffey K, Mandala SM, Proia RL, Hla T. Essential role of sphingosine 1-phosphate receptor 2 in pathological angiogenesis of the mouse retina. J Clin Invest. 2007 Sep; 117(9):2506-16. PMID: 17710232.
    Citations: 75     Fields:    Translation:HumansAnimalsCells
  109. Ghosh M, Wang H, Ai Y, Romeo E, Luyendyk JP, Peters JM, Mackman N, Dey SK, Hla T. COX-2 suppresses tissue factor expression via endocannabinoid-directed PPARdelta activation. J Exp Med. 2007 Sep 03; 204(9):2053-61. PMID: 17724132.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  110. Lee YM, Venkataraman K, Hwang SI, Han DK, Hla T. A novel method to quantify sphingosine 1-phosphate by immobilized metal affinity chromatography (IMAC). Prostaglandins Other Lipid Mediat. 2007 Nov; 84(3-4):154-62. PMID: 17991617.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  111. Soldi R, Mandinova A, Venkataraman K, Hla T, Vadas M, Pitson S, Duarte M, Graziani I, Kolev V, Kacer D, Kirov A, Maciag T, Prudovsky I. Sphingosine kinase 1 is a critical component of the copper-dependent FGF1 export pathway. Exp Cell Res. 2007 Sep 10; 313(15):3308-18. PMID: 17643421.
    Citations: 13     Fields:    Translation:AnimalsCells
  112. Sanchez T, Skoura A, Wu MT, Casserly B, Harrington EO, Hla T. Induction of vascular permeability by the sphingosine-1-phosphate receptor-2 (S1P2R) and its downstream effectors ROCK and PTEN. Arterioscler Thromb Vasc Biol. 2007 Jun; 27(6):1312-8. PMID: 17431187.
    Citations: 95     Fields:    Translation:HumansAnimalsCells
  113. Kono M, Belyantseva IA, Skoura A, Frolenkov GI, Starost MF, Dreier JL, Lidington D, Bolz SS, Friedman TB, Hla T, Proia RL. Deafness and stria vascularis defects in S1P2 receptor-null mice. J Biol Chem. 2007 Apr 06; 282(14):10690-6. PMID: 17284444.
    Citations: 66     Fields:    Translation:AnimalsCells
  114. Oo ML, Thangada S, Wu MT, Liu CH, Macdonald TL, Lynch KR, Lin CY, Hla T. Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor. J Biol Chem. 2007 Mar 23; 282(12):9082-9. PMID: 17237497.
    Citations: 135     Fields:    Translation:HumansCells
  115. Gonzalez-Cabrera PJ, Hla T, Rosen H. Mapping pathways downstream of sphingosine 1-phosphate subtype 1 by differential chemical perturbation and proteomics. J Biol Chem. 2007 Mar 09; 282(10):7254-64. PMID: 17218309.
    Citations: 33     Fields:    Translation:HumansCells
  116. Hla T, Feinmark SJ. A festschrift for J. Martyn Bailey, a biochemist extraordinaire. Prostaglandins Other Lipid Mediat. 2007 Feb; 83(1-2):154-7. PMID: 17259082.
    Citations:    Fields:    
  117. Kohno M, Momoi M, Oo ML, Paik JH, Lee YM, Venkataraman K, Ai Y, Ristimaki AP, Fyrst H, Sano H, Rosenberg D, Saba JD, Proia RL, Hla T. Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation. Mol Cell Biol. 2006 Oct; 26(19):7211-23. PMID: 16980623.
    Citations: 94     Fields:    Translation:HumansAnimalsCells
  118. Lee JF, Zeng Q, Ozaki H, Wang L, Hand AR, Hla T, Wang E, Lee MJ. Dual roles of tight junction-associated protein, zonula occludens-1, in sphingosine 1-phosphate-mediated endothelial chemotaxis and barrier integrity. J Biol Chem. 2006 Sep 29; 281(39):29190-200. PMID: 16891661.
    Citations: 58     Fields:    Translation:HumansCells
  119. Venkataraman K, Thangada S, Michaud J, Oo ML, Ai Y, Lee YM, Wu M, Parikh NS, Khan F, Proia RL, Hla T. Extracellular export of sphingosine kinase-1a contributes to the vascular S1P gradient. Biochem J. 2006 Aug 01; 397(3):461-71. PMID: 16623665.
    Citations: 77     Fields:    Translation:HumansAnimalsCells
  120. Michaud J, Kohno M, Proia RL, Hla T. Normal acute and chronic inflammatory responses in sphingosine kinase 1 knockout mice. FEBS Lett. 2006 Aug 21; 580(19):4607-12. PMID: 16876794.
    Citations: 29     Fields:    Translation:AnimalsCells
  121. Thompson B, Ancellin N, Fernandez SM, Hla T, Sha'afi RI. Protein kinase Calpha and sphingosine 1-phosphate-dependent signaling in endothelial cell. Prostaglandins Other Lipid Mediat. 2006 Jul; 80(1-2):15-27. PMID: 16846783.
    Citations: 3     Fields:    Translation:HumansCells
  122. Subbaramaiah K, Howe LR, Port ER, Brogi E, Fishman J, Liu CH, Hla T, Hudis C, Dannenberg AJ. HER-2/neu status is a determinant of mammary aromatase activity in vivo: evidence for a cyclooxygenase-2-dependent mechanism. Cancer Res. 2006 May 15; 66(10):5504-11. PMID: 16707480.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  123. Kitano M, Hla T, Sekiguchi M, Kawahito Y, Yoshimura R, Miyazawa K, Iwasaki T, Sano H, Saba JD, Tam YY. Sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 signaling in rheumatoid synovium: regulation of synovial proliferation and inflammatory gene expression. Arthritis Rheum. 2006 Mar; 54(3):742-53. PMID: 16508938.
    Citations: 59     Fields:    Translation:HumansCells
  124. Lee JF, Ozaki H, Zhan X, Wang E, Hla T, Lee MJ. Sphingosine-1-phosphate signaling regulates lamellipodia localization of cortactin complexes in endothelial cells. Histochem Cell Biol. 2006 Sep; 126(3):297-304. PMID: 16416022.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  125. LaMontagne K, Littlewood-Evans A, Schnell C, O'Reilly T, Wyder L, Sanchez T, Probst B, Butler J, Wood A, Liau G, Billy E, Theuer A, Hla T, Wood J. Antagonism of sphingosine-1-phosphate receptors by FTY720 inhibits angiogenesis and tumor vascularization. Cancer Res. 2006 Jan 01; 66(1):221-31. PMID: 16397235.
    Citations: 86     Fields:    Translation:HumansAnimalsCells
  126. Howe LR, Chang SH, Tolle KC, Dillon R, Young LJ, Cardiff RD, Newman RA, Yang P, Thaler HT, Muller WJ, Hudis C, Brown AM, Hla T, Subbaramaiah K, Dannenberg AJ. HER2/neu-induced mammary tumorigenesis and angiogenesis are reduced in cyclooxygenase-2 knockout mice. Cancer Res. 2005 Nov 01; 65(21):10113-9. PMID: 16267038.
    Citations: 46     Fields:    Translation:Animals
  127. Hla T. Immunology. Dietary factors and immunological consequences. Science. 2005 Sep 09; 309(5741):1682-3. PMID: 16150998.
    Citations: 5     Fields:    Translation:AnimalsCells
  128. Rapaka RS, Hla T, Dey SK. The dawn of lipidomics. Prostaglandins Other Lipid Mediat. 2005 Sep; 77(1-4):1-3. PMID: 16099385.
    Citations:    Fields:    Translation:HumansAnimals
  129. Hla T. Genomic insights into mediator lipidomics. Prostaglandins Other Lipid Mediat. 2005 Sep; 77(1-4):197-209. PMID: 16099404.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  130. Jo E, Sanna MG, Gonzalez-Cabrera PJ, Thangada S, Tigyi G, Osborne DA, Hla T, Parrill AL, Rosen H. S1P1-selective in vivo-active agonists from high-throughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate. Chem Biol. 2005 Jun; 12(6):703-15. PMID: 15975516.
    Citations: 83     Fields:    Translation:HumansAnimalsCells
  131. Chang SH, Ai Y, Breyer RM, Lane TF, Hla T. The prostaglandin E2 receptor EP2 is required for cyclooxygenase 2-mediated mammary hyperplasia. Cancer Res. 2005 Jun 01; 65(11):4496-9. PMID: 15930264.
    Citations: 36     Fields:    Translation:AnimalsCells
  132. Lepley D, Paik JH, Hla T, Ferrer F. The G protein-coupled receptor S1P2 regulates Rho/Rho kinase pathway to inhibit tumor cell migration. Cancer Res. 2005 May 01; 65(9):3788-95. PMID: 15867375.
    Citations: 56     Fields:    Translation:HumansCells
  133. Narko K, Zweifel B, Trifan O, Ristimäki A, Lane TF, Hla T. COX-2 inhibitors and genetic background reduce mammary tumorigenesis in cyclooxygenase-2 transgenic mice. Prostaglandins Other Lipid Mediat. 2005 May; 76(1-4):86-94. PMID: 15967164.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  134. Chang SH, Liu CH, Wu MT, Hla T. Regulation of vascular endothelial cell growth factor expression in mouse mammary tumor cells by the EP2 subtype of the prostaglandin E2 receptor. Prostaglandins Other Lipid Mediat. 2005 May; 76(1-4):48-58. PMID: 15967161.
    Citations: 13     Fields:    Translation:AnimalsCells
  135. Heinonen M, Bono P, Narko K, Chang SH, Lundin J, Joensuu H, Furneaux H, Hla T, Haglund C, Ristimäki A. Cytoplasmic HuR expression is a prognostic factor in invasive ductal breast carcinoma. Cancer Res. 2005 Mar 15; 65(6):2157-61. PMID: 15781626.
    Citations: 95     Fields:    Translation:HumansAnimalsCells
  136. Sanchez T, Thangada S, Wu MT, Kontos CD, Wu D, Wu H, Hla T. PTEN as an effector in the signaling of antimigratory G protein-coupled receptor. Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12):4312-7. PMID: 15764699.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  137. Chae SS, Hla T. Inhibition of gene expression in vivo using multiplex siRNA. Methods Mol Biol. 2005; 309:197-203. PMID: 15990401.
    Citations: 1     Fields:    Translation:HumansAnimals
  138. Knostman KA, Cho JY, Ryu KY, Lin X, McCubrey JA, Hla T, Liu CH, Di Carlo E, Keri R, Zhang M, Hwang DY, Kisseberth WC, Capen CC, Jhiang SM. Signaling through 3',5'-cyclic adenosine monophosphate and phosphoinositide-3 kinase induces sodium/iodide symporter expression in breast cancer. J Clin Endocrinol Metab. 2004 Oct; 89(10):5196-203. PMID: 15472226.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  139. Hla T. Physiological and pathological actions of sphingosine 1-phosphate. Semin Cell Dev Biol. 2004 Oct; 15(5):513-20. PMID: 15271296.
    Citations: 120     Fields:    Translation:HumansAnimals
  140. Chae SS, Paik JH, Furneaux H, Hla T. Requirement for sphingosine 1-phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference. J Clin Invest. 2004 Oct; 114(8):1082-9. PMID: 15489955.
    Citations: 66     Fields:    Translation:AnimalsCells
  141. Paik JH, Skoura A, Chae SS, Cowan AE, Han DK, Proia RL, Hla T. Sphingosine 1-phosphate receptor regulation of N-cadherin mediates vascular stabilization. Genes Dev. 2004 Oct 01; 18(19):2392-403. PMID: 15371328.
    Citations: 89     Fields:    Translation:AnimalsCells
  142. Sanchez T, Hla T. Structural and functional characteristics of S1P receptors. J Cell Biochem. 2004 Aug 01; 92(5):913-22. PMID: 15258915.
    Citations: 153     Fields:    Translation:HumansAnimalsCells
  143. Brinkmann V, Cyster JG, Hla T. FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function. Am J Transplant. 2004 Jul; 4(7):1019-25. PMID: 15196057.
    Citations: 116     Fields:    Translation:HumansAnimalsCells
  144. Chae SS, Paik JH, Allende ML, Proia RL, Hla T. Regulation of limb development by the sphingosine 1-phosphate receptor S1p1/EDG-1 occurs via the hypoxia/VEGF axis. Dev Biol. 2004 Apr 15; 268(2):441-7. PMID: 15063179.
    Citations: 17     Fields:    Translation:Animals
  145. Saba JD, Hla T. Point-counterpoint of sphingosine 1-phosphate metabolism. Circ Res. 2004 Apr 02; 94(6):724-34. PMID: 15059942.
    Citations: 83     Fields:    Translation:HumansAnimalsCells
  146. Jang BC, Kim DH, Park JW, Kwon TK, Kim SP, Song DK, Park JG, Bae JH, Mun KC, Baek WK, Suh MH, Hla T, Suh SI. Induction of cyclooxygenase-2 in macrophages by catalase: role of NF-kappaB and PI3K signaling pathways. Biochem Biophys Res Commun. 2004 Apr 02; 316(2):398-406. PMID: 15020231.
    Citations: 4     Fields:    Translation:AnimalsCells
  147. Hla T. Prostaglandins & other lipid mediators: a new phase, a new team. Prostaglandins Other Lipid Mediat. 2004 Jan; 73(1-2):1-2. PMID: 15165026.
    Citations: 2     Fields:    
  148. Chae SS, Proia RL, Hla T. Constitutive expression of the S1P1 receptor in adult tissues. Prostaglandins Other Lipid Mediat. 2004 Jan; 73(1-2):141-50. PMID: 15165038.
    Citations: 34     Fields:    Translation:AnimalsCells
  149. Chang SH, Liu CH, Conway R, Han DK, Nithipatikom K, Trifan OC, Lane TF, Hla T. Role of prostaglandin E2-dependent angiogenic switch in cyclooxygenase 2-induced breast cancer progression. Proc Natl Acad Sci U S A. 2004 Jan 13; 101(2):591-6. PMID: 14688410.
    Citations: 109     Fields:    Translation:Animals
  150. Erkinheimo TL, Lassus H, Sivula A, Sengupta S, Furneaux H, Hla T, Haglund C, Butzow R, Ristimäki A. Cytoplasmic HuR expression correlates with poor outcome and with cyclooxygenase 2 expression in serous ovarian carcinoma. Cancer Res. 2003 Nov 15; 63(22):7591-4. PMID: 14633672.
    Citations: 58     Fields:    Translation:HumansCells
  151. Sanchez T, Estrada-Hernandez T, Paik JH, Wu MT, Venkataraman K, Brinkmann V, Claffey K, Hla T. Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability. J Biol Chem. 2003 Nov 21; 278(47):47281-90. PMID: 12954648.
    Citations: 124     Fields:    Translation:HumansAnimalsCells
  152. Hla T. Signaling and biological actions of sphingosine 1-phosphate. Pharmacol Res. 2003 May; 47(5):401-7. PMID: 12676514.
    Citations: 75     Fields:    Translation:AnimalsCells
  153. Sengupta S, Jang BC, Wu MT, Paik JH, Furneaux H, Hla T. The RNA-binding protein HuR regulates the expression of cyclooxygenase-2. J Biol Chem. 2003 Jul 04; 278(27):25227-33. PMID: 12704185.
    Citations: 51     Fields:    Translation:HumansCells
  154. Inaba T, Sano H, Kawahito Y, Hla T, Akita K, Toda M, Yamashina I, Inoue M, Nakada H. Induction of cyclooxygenase-2 in monocyte/macrophage by mucins secreted from colon cancer cells. Proc Natl Acad Sci U S A. 2003 Mar 04; 100(5):2736-41. PMID: 12598658.
    Citations: 18     Fields:    Translation:HumansCells
  155. Donohue PJ, Richards CM, Brown SA, Hanscom HN, Buschman J, Thangada S, Hla T, Williams MS, Winkles JA. TWEAK is an endothelial cell growth and chemotactic factor that also potentiates FGF-2 and VEGF-A mitogenic activity. Arterioscler Thromb Vasc Biol. 2003 Apr 01; 23(4):594-600. PMID: 12615668.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  156. Kluk MJ, Colmont C, Wu MT, Hla T. Platelet-derived growth factor (PDGF)-induced chemotaxis does not require the G protein-coupled receptor S1P1 in murine embryonic fibroblasts and vascular smooth muscle cells. FEBS Lett. 2003 Jan 02; 533(1-3):25-8. PMID: 12505153.
    Citations: 8     Fields:    Translation:AnimalsCells
  157. Ozaki H, Hla T, Lee MJ. Sphingosine-1-phosphate signaling in endothelial activation. J Atheroscler Thromb. 2003; 10(3):125-31. PMID: 14564080.
    Citations: 20     Fields:    Translation:HumansCells
  158. Jang BC, Muñoz-Najar U, Paik JH, Claffey K, Yoshida M, Hla T. Leptomycin B, an inhibitor of the nuclear export receptor CRM1, inhibits COX-2 expression. J Biol Chem. 2003 Jan 31; 278(5):2773-6. PMID: 12468543.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  159. Bishop-Bailey D, Hla T, Warner TD. Intimal smooth muscle cells as a target for peroxisome proliferator-activated receptor-gamma ligand therapy. Circ Res. 2002 Aug 09; 91(3):210-7. PMID: 12169646.
    Citations: 12     Fields:    Translation:AnimalsCells
  160. Chun J, Goetzl EJ, Hla T, Igarashi Y, Lynch KR, Moolenaar W, Pyne S, Tigyi G. International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclature. Pharmacol Rev. 2002 Jun; 54(2):265-9. PMID: 12037142.
    Citations: 128     Fields:    Translation:HumansAnimals
  161. Kluk MJ, Hla T. Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors. Biochim Biophys Acta. 2002 May 23; 1582(1-3):72-80. PMID: 12069812.
    Citations: 67     Fields:    Translation:HumansAnimals
  162. Ancellin N, Colmont C, Su J, Li Q, Mittereder N, Chae SS, Stefansson S, Liau G, Hla T. Extracellular export of sphingosine kinase-1 enzyme. Sphingosine 1-phosphate generation and the induction of angiogenic vascular maturation. J Biol Chem. 2002 Feb 22; 277(8):6667-75. PMID: 11741921.
    Citations: 79     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.