Harvard Catalyst Profiles

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Steven Swendeman, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Niaudet C, Jung B, Kuo A, Swendeman S, Bull E, Seno T, Crocker R, Fu Z, Smith LEH, Hla T. Therapeutic activation of endothelial sphingosine-1-phosphate receptor 1 by chaperone-bound S1P suppresses proliferative retinal neovascularization. EMBO Mol Med. 2023 Mar 13; e16645. PMID: 36912000.
    Citations:    Fields:    
  2. Diebel LN, Liberati DM, Hla T, Swendeman S. Plasma components to protect the endothelial barrier after shock: A role for sphingosine 1-phosphate. Surgery. 2022 03; 171(3):825-832. PMID: 34865862.
    Citations: 1     Fields:    Translation:HumansCells
  3. Ding BS, Yang D, Swendeman SL, Christoffersen C, Nielsen LB, Friedman SL, Powell CA, Hla T, Cao Z. Aging Suppresses Sphingosine-1-Phosphate Chaperone ApoM in Circulation Resulting in Maladaptive Organ Repair. Dev Cell. 2020 06 22; 53(6):677-690.e4. PMID: 32544390.
    Citations: 14     Fields:    Translation:AnimalsCells
  4. Weskamp G, Tüshaus J, Li D, Feederle R, Maretzky T, Swendemann S, Falck-Pedersen E, McIlwain DR, Mak TW, Salmon JE, Lichtenthaler SF, Blobel CP. ADAM17 stabilizes its interacting partner inactive Rhomboid 2 (iRhom2) but not inactive Rhomboid 1 (iRhom1). J Biol Chem. 2020 03 27; 295(13):4350-4358. PMID: 32060096.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  5. Yanagida K, Engelbrecht E, Niaudet C, Jung B, Gaengel K, Holton K, Swendeman S, Liu CH, Levesque MV, Kuo A, Fu Z, Smith LEH, Betsholtz C, Hla T. Sphingosine 1-Phosphate Receptor Signaling Establishes AP-1 Gradients to Allow for Retinal Endothelial Cell Specialization. Dev Cell. 2020 03 23; 52(6):779-793.e7. PMID: 32059774.
    Citations: 19     Fields:    Translation:AnimalsCells
  6. Obinata H, Kuo A, Wada Y, Swendeman S, Liu CH, Blaho VA, Nagumo R, Satoh K, Izumi T, Hla T. Identification of ApoA4 as a sphingosine 1-phosphate chaperone in ApoM- and albumin-deficient mice. J Lipid Res. 2019 11; 60(11):1912-1921. PMID: 31462513.
    Citations: 20     Fields:    Translation:AnimalsCells
  7. Swendeman SL, Hla T. Lipid Mediators, M2 Macrophages, and Pathological Neovascularization. Trends Mol Med. 2018 12; 24(12):977-978. PMID: 30448396; PMCID: PMC6876743.
    Citations:    Fields:    Translation:HumansAnimalsCells
  8. Burg N, Swendeman S, Worgall S, Hla T, Salmon JE. Sphingosine 1-Phosphate Receptor 1 Signaling Maintains Endothelial Cell Barrier Function and Protects Against Immune Complex-Induced Vascular Injury. Arthritis Rheumatol. 2018 11; 70(11):1879-1889. PMID: 29781582; PMCID: PMC6734184.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  9. Swendeman SL, Xiong Y, Cantalupo A, Yuan H, Burg N, Hisano Y, Cartier A, Liu CH, Engelbrecht E, Blaho V, Zhang Y, Yanagida K, Galvani S, Obinata H, Salmon JE, Sanchez T, Di Lorenzo A, Hla T. An engineered S1P chaperone attenuates hypertension and ischemic injury. Sci Signal. 2017 Aug 15; 10(492). PMID: 28811382.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  10. Maretzky T, Swendeman S, Mogollon E, Weskamp G, Sahin U, Reiss K, Blobel CP. Characterization of the catalytic properties of the membrane-anchored metalloproteinase ADAM9 in cell-based assays. Biochem J. 2017 04 13; 474(9):1467-1479. PMID: 28264989.
    Citations: 14     Fields:    Translation:AnimalsCells
  11. Ding BS, Liu CH, Sun Y, Chen Y, Swendeman SL, Jung B, Chavez D, Cao Z, Christoffersen C, Nielsen LB, Schwab SR, Rafii S, Hla T. HDL activation of endothelial sphingosine-1-phosphate receptor-1 (S1P1) promotes regeneration and suppresses fibrosis in the liver. JCI Insight. 2016 Dec 22; 1(21):e87058. PMID: 28018969; PMCID: PMC5161208.
    Citations: 27     Fields:    
  12. Christensen PM, Liu CH, Swendeman SL, Obinata H, Qvortrup K, Nielsen LB, Hla T, Di Lorenzo A, Christoffersen C. Impaired endothelial barrier function in apolipoprotein M-deficient mice is dependent on sphingosine-1-phosphate receptor 1. FASEB J. 2016 06; 30(6):2351-9. PMID: 26956418; PMCID: PMC4871798.
    Citations: 45     Fields:    Translation:Animals
  13. Galvani S, Sanson M, Blaho VA, Swendeman SL, Obinata H, Conger H, Dahlbäck B, Kono M, Proia RL, Smith JD, Hla T. HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1 to limit vascular inflammation. Sci Signal. 2015 Aug 11; 8(389):ra79. PMID: 26268607.
    Citations: 127     Fields:    Translation:HumansAnimalsCells
  14. Blaho VA, Galvani S, Engelbrecht E, Liu C, Swendeman SL, Kono M, Proia RL, Steinman L, Han MH, Hla T. HDL-bound sphingosine-1-phosphate restrains lymphopoiesis and neuroinflammation. Nature. 2015 Jul 16; 523(7560):342-6. PMID: 26053123.
    Citations: 103     Fields:    Translation:AnimalsCells
  15. Hewing NJ, Weskamp G, Vermaat J, Farage E, Glomski K, Swendeman S, Chan RV, Chiang MF, Khokha R, Anand-Apte B, Blobel CP. Intravitreal injection of TIMP3 or the EGFR inhibitor erlotinib offers protection from oxygen-induced retinopathy in mice. Invest Ophthalmol Vis Sci. 2013 Jan 30; 54(1):864-70. PMID: 23299479; PMCID: PMC3562132.
    Citations: 15     Fields:    Translation:AnimalsCells
  16. Issuree PD, Maretzky T, McIlwain DR, Monette S, Qing X, Lang PA, Swendeman SL, Park-Min KH, Binder N, Kalliolias GD, Yarilina A, Horiuchi K, Ivashkiv LB, Mak TW, Salmon JE, Blobel CP. iRHOM2 is a critical pathogenic mediator of inflammatory arthritis. J Clin Invest. 2013 Feb; 123(2):928-32. PMID: 23348744; PMCID: PMC3561822.
    Citations: 83     Fields:    Translation:HumansAnimalsCells
  17. Maretzky T, Evers A, Zhou W, Swendeman SL, Wong PM, Rafii S, Reiss K, Blobel CP. Migration of growth factor-stimulated epithelial and endothelial cells depends on EGFR transactivation by ADAM17. Nat Commun. 2011; 2:229. PMID: 21407195.
    Citations: 73     Fields:    Translation:HumansAnimalsCells
  18. Mendelson K, Swendeman S, Saftig P, Blobel CP. Stimulation of platelet-derived growth factor receptor beta (PDGFRbeta) activates ADAM17 and promotes metalloproteinase-dependent cross-talk between the PDGFRbeta and epidermal growth factor receptor (EGFR) signaling pathways. J Biol Chem. 2010 Aug 06; 285(32):25024-32. PMID: 20529858.
    Citations: 29     Fields:    Translation:AnimalsCells
  19. Guaiquil VH, Swendeman S, Zhou W, Guaiquil P, Weskamp G, Bartsch JW, Blobel CP. ADAM8 is a negative regulator of retinal neovascularization and of the growth of heterotopically injected tumor cells in mice. J Mol Med (Berl). 2010 May; 88(5):497-505. PMID: 20119708.
    Citations: 21     Fields:    Translation:AnimalsCells
  20. Weskamp G, Mendelson K, Swendeman S, Le Gall S, Ma Y, Lyman S, Hinoki A, Eguchi S, Guaiquil V, Horiuchi K, Blobel CP. Pathological neovascularization is reduced by inactivation of ADAM17 in endothelial cells but not in pericytes. Circ Res. 2010 Mar 19; 106(5):932-40. PMID: 20110534.
    Citations: 71     Fields:    Translation:AnimalsCells
  21. Parry DA, Toomes C, Bida L, Danciger M, Towns KV, McKibbin M, Jacobson SG, Logan CV, Ali M, Bond J, Chance R, Swendeman S, Daniele LL, Springell K, Adams M, Johnson CA, Booth AP, Jafri H, Rashid Y, Banin E, Strom TM, Farber DB, Sharon D, Blobel CP, Pugh EN, Pierce EA, Inglehearn CF. Loss of the metalloprotease ADAM9 leads to cone-rod dystrophy in humans and retinal degeneration in mice. Am J Hum Genet. 2009 May; 84(5):683-91. PMID: 19409519.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  22. Guaiquil V, Swendeman S, Yoshida T, Chavala S, Campochiaro PA, Blobel CP. ADAM9 is involved in pathological retinal neovascularization. Mol Cell Biol. 2009 May; 29(10):2694-703. PMID: 19273593.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  23. Swendeman S, Mendelson K, Weskamp G, Horiuchi K, Deutsch U, Scherle P, Hooper A, Rafii S, Blobel CP. VEGF-A stimulates ADAM17-dependent shedding of VEGFR2 and crosstalk between VEGFR2 and ERK signaling. Circ Res. 2008 Oct 24; 103(9):916-8. PMID: 18818406; PMCID: PMC2574836.
    Citations: 80     Fields:    Translation:HumansAnimalsCells
  24. Weskamp G, Ford JW, Sturgill J, Martin S, Docherty AJ, Swendeman S, Broadway N, Hartmann D, Saftig P, Umland S, Sehara-Fujisawa A, Black RA, Ludwig A, Becherer JD, Conrad DH, Blobel CP. ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23. Nat Immunol. 2006 Dec; 7(12):1293-8. PMID: 17072319.
    Citations: 103     Fields:    Translation:HumansAnimalsCells
  25. Pearse RN, Swendeman SL, Li Y, Rafii D, Hempstead BL. A neurotrophin axis in myeloma: TrkB and BDNF promote tumor-cell survival. Blood. 2005 Jun 01; 105(11):4429-36. PMID: 15657181.
    Citations: 57     Fields:    Translation:HumansCells
  26. Wisniewski D, Strife A, Swendeman S, Erdjument-Bromage H, Geromanos S, Kavanaugh WM, Tempst P, Clarkson B. A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells. Blood. 1999 Apr 15; 93(8):2707-20. PMID: 10194451.
    Citations: 31     Fields:    Translation:HumansCells
  27. Zhong F, Swendeman SL, Popik W, Pitha PM, Sheffery M. Evidence that levels of the dimeric cellular transcription factor CP2 play little role in the activation of the HIV-1 long terminal repeat in vivo or following superinfection with herpes simplex virus type 1. J Biol Chem. 1994 Aug 19; 269(33):21269-76. PMID: 8063751.
    Citations: 13     Fields:    Translation:Cells
  28. Swendeman SL, Spielholz C, Jenkins NA, Gilbert DJ, Copeland NG, Sheffery M. Characterization of the genomic structure, chromosomal location, promoter, and development expression of the alpha-globin transcription factor CP2. J Biol Chem. 1994 Apr 15; 269(15):11663-71. PMID: 8157699.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  29. Lim LC, Fang L, Swendeman SL, Sheffery M. Characterization of the molecularly cloned murine alpha-globin transcription factor CP2. J Biol Chem. 1993 Aug 25; 268(24):18008-17. PMID: 8349681.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.