Harvard Catalyst Profiles

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Michael Wheeler, Ph.D.

Title
Institution
Department
Address
Profile Picture

Biography
education and training
Johns Hopkins University, Baltimore, MDB.A.12/2010Neuroscience, Philosophy
University of Virginia, Charlottesville, VAPhD05/2016Neuroscience
Brigham and Women's Hospital, Boston, MAPostdoc10/2020Neuroimmunology
Brigham and Women's Hospital, Boston, MAInstructor11/2022Neuroimmunology

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
Most Recent  |  List All
  1. R00NS114111 (WHEELER, MICHAEL ALEX) Feb 1, 2023 - Jan 31, 2026
    NIH
    Molecular Control of Astrocytes in CNS Inflammation
    Role: Principal Investigator
  2. R01MH130458 (WHEELER, MICHAEL ALEX) Aug 15, 2022 - Jul 30, 2027
    NIH
    Control of extracellular matrix remodeling by CD29+ astrocytes
    Role: Principal Investigator
  3. K99NS114111 (WHEELER, MICHAEL ALEX) Aug 15, 2020 - Jul 30, 2022
    NIH
    Molecular Control of Astrocytes in CNS Inflammation
    Role: Principal Investigator
  4. F32NS101790 (WHEELER, MICHAEL ALEX) Dec 1, 2017 - Sep 30, 2019
    NIH
    The role of the IFNAR1/AhR signaling axis in astrocyte regulation and remediation of multiple sclerosis pathogenesis
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Wheeler MA, Clark IC, Lee HG, Li Z, Linnerbauer M, Rone JM, Blain M, Akl CF, Piester G, Giovannoni F, Charabati M, Lee JH, Kye YC, Choi J, Sanmarco LM, Srun L, Chung EN, Flausino LE, Andersen BM, Rothhammer V, Yano H, Illouz T, Zandee SEJ, Daniel C, Artis D, Prinz M, Abate AR, Kuchroo VK, Antel JP, Prat A, Quintana FJ. Droplet-based forward genetic screening of astrocyte-microglia cross-talk. Science. 2023 03 10; 379(6636):1023-1030. PMID: 36893254.
    Citations:    Fields:    
  2. Clark IC, Mudvari P, Thaploo S, Smith S, Abu-Laban M, Hamouda M, Theberge M, Shah S, Ko SH, Pérez L, Bunis DG, Lee JS, Kilam D, Zakaria S, Choi S, Darko S, Henry AR, Wheeler MA, Hoh R, Butrus S, Deeks SG, Quintana FJ, Douek DC, Abate AR, Boritz EA. HIV silencing and cell survival signatures in infected T cell reservoirs. Nature. 2023 Feb; 614(7947):318-325. PMID: 36599978; PMCID: PMC9908556.
    Citations:    Fields:    Translation:HumansCells
  3. Clark IC, Wheeler MA, Lee HG, Li Z, Sanmarco LM, Thaploo S, Polonio CM, Shin SW, Scalisi G, Henry AR, Rone JM, Giovannoni F, Charabati M, Akl CF, Aleman DM, Zandee SEJ, Prat A, Douek DC, Boritz EA, Quintana FJ, Abate AR. Identification of astrocyte regulators by nucleic acid cytometry. Nature. 2023 Feb; 614(7947):326-333. PMID: 36599367; PMCID: PMC9980163.
    Citations:    Fields:    Translation:HumansAnimalsCells
  4. Sanmarco LM, Chao CC, Wang YC, Kenison JE, Li Z, Rone JM, Rejano-Gordillo CM, Polonio CM, Gutierrez-Vazquez C, Piester G, Plasencia A, Li L, Giovannoni F, Lee HG, Faust Akl C, Wheeler MA, Mascanfroni I, Jaronen M, Alsuwailm M, Hewson P, Yeste A, Andersen BM, Franks DG, Huang CJ, Ekwudo M, Tjon EC, Rothhammer V, Takenaka M, de Lima KA, Linnerbauer M, Guo L, Covacu R, Queva H, Fonseca-Castro PH, Bladi MA, Cox LM, Hodgetts KJ, Hahn ME, Mildner A, Korzenik J, Hauser R, Snapper SB, Quintana FJ. Identification of environmental factors that promote intestinal inflammation. Nature. 2022 11; 611(7937):801-809. PMID: 36266581; PMCID: PMC9898826.
    Citations: 5     Fields:    Translation:AnimalsCells
  5. Lee HG, Wheeler MA, Quintana FJ. Function and therapeutic value of astrocytes in neurological diseases. Nat Rev Drug Discov. 2022 05; 21(5):339-358. PMID: 35173313; PMCID: PMC9081171.
    Citations: 27     Fields:    Translation:HumansCells
  6. Jaronen M, Wheeler MA, Quintana FJ. Protocol for inducing inflammation and acute myelin degeneration in larval zebrafish. STAR Protoc. 2022 03 18; 3(1):101134. PMID: 35128477; PMCID: PMC8808285.
    Citations: 1     Fields:    Translation:AnimalsCells
  7. Andersen BM, Faust Akl C, Wheeler MA, Chiocca EA, Reardon DA, Quintana FJ. Glial and myeloid heterogeneity in the brain tumour microenvironment. Nat Rev Cancer. 2021 12; 21(12):786-802. PMID: 34584243; PMCID: PMC8616823.
    Citations: 24     Fields:    Translation:HumansCells
  8. Sanmarco LM, Polonio CM, Wheeler MA, Quintana FJ. Functional immune cell-astrocyte interactions. J Exp Med. 2021 09 06; 218(9). PMID: 34292315; PMCID: PMC8302447.
    Citations: 14     Fields:    Translation:HumansCells
  9. Clark IC, Gutiérrez-Vázquez C, Wheeler MA, Li Z, Rothhammer V, Linnerbauer M, Sanmarco LM, Guo L, Blain M, Zandee SEJ, Chao CC, Batterman KV, Schwabenland M, Lotfy P, Tejeda-Velarde A, Hewson P, Manganeli Polonio C, Shultis MW, Salem Y, Tjon EC, Fonseca-Castro PH, Borucki DM, Alves de Lima K, Plasencia A, Abate AR, Rosene DL, Hodgetts KJ, Prinz M, Antel JP, Prat A, Quintana FJ. Barcoded viral tracing of single-cell interactions in central nervous system inflammation. Science. 2021 04 23; 372(6540). PMID: 33888612; PMCID: PMC8157482.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  10. Prinz M, Masuda T, Wheeler MA, Quintana FJ. Microglia and Central Nervous System-Associated Macrophages-From Origin to Disease Modulation. Annu Rev Immunol. 2021 04 26; 39:251-277. PMID: 33556248.
    Citations: 77     Fields:    Translation:HumansAnimalsCells
  11. Sanmarco LM, Wheeler MA, Gutiérrez-Vázquez C, Polonio CM, Linnerbauer M, Pinho-Ribeiro FA, Li Z, Giovannoni F, Batterman KV, Scalisi G, Zandee SEJ, Heck ES, Alsuwailm M, Rosene DL, Becher B, Chiu IM, Prat A, Quintana FJ. Gut-licensed IFN?+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes. Nature. 2021 02; 590(7846):473-479. PMID: 33408417; PMCID: PMC8039910.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  12. Giovannoni F, Bosch I, Polonio CM, Torti MF, Wheeler MA, Li Z, Romorini L, Rodriguez Varela MS, Rothhammer V, Barroso A, Tjon EC, Sanmarco LM, Takenaka MC, Modaresi SMS, Gutiérrez-Vázquez C, Zanluqui NG, Dos Santos NB, Munhoz CD, Wang Z, Damonte EB, Sherr D, Gehrke L, Peron JPS, Garcia CC, Quintana FJ. Author Correction: AHR is a Zika virus host factor and a candidate target for antiviral therapy. Nat Neurosci. 2020 Oct; 23(10):1307. PMID: 32778795.
    Citations:    Fields:    
  13. Badimon A, Strasburger HJ, Ayata P, Chen X, Nair A, Ikegami A, Hwang P, Chan AT, Graves SM, Uweru JO, Ledderose C, Kutlu MG, Wheeler MA, Kahan A, Ishikawa M, Wang YC, Loh YE, Jiang JX, Surmeier DJ, Robson SC, Junger WG, Sebra R, Calipari ES, Kenny PJ, Eyo UB, Colonna M, Quintana FJ, Wake H, Gradinaru V, Schaefer A. Negative feedback control of neuronal activity by microglia. Nature. 2020 10; 586(7829):417-423. PMID: 32999463; PMCID: PMC7577179.
    Citations: 201     Fields:    Translation:HumansAnimalsCells
  14. Linnerbauer M, Wheeler MA, Quintana FJ. Astrocyte Crosstalk in CNS Inflammation. Neuron. 2020 11 25; 108(4):608-622. PMID: 32898475.
    Citations: 174     Fields:    Translation:HumansAnimalsCells
  15. Giovannoni F, Bosch I, Polonio CM, Torti MF, Wheeler MA, Li Z, Romorini L, Rodriguez Varela MS, Rothhammer V, Barroso A, Tjon EC, Sanmarco LM, Takenaka MC, Modaresi SMS, Gutiérrez-Vázquez C, Zanluqui NG, Dos Santos NB, Munhoz CD, Wang Z, Damonte EB, Sherr D, Gehrke L, Peron JPS, Garcia CC, Quintana FJ. AHR is a Zika virus host factor and a candidate target for antiviral therapy. Nat Neurosci. 2020 08; 23(8):939-951. PMID: 32690969; PMCID: PMC7897397.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  16. Alaamery M, Albesher N, Aljawini N, Alsuwailm M, Massadeh S, Wheeler MA, Chao CC, Quintana FJ. Role of sphingolipid metabolism in neurodegeneration. J Neurochem. 2021 07; 158(1):25-35. PMID: 32402091; PMCID: PMC7665988.
    Citations: 20     Fields:    Translation:HumansAnimals
  17. Wheeler MA, Clark IC, Tjon EC, Li Z, Zandee SEJ, Couturier CP, Watson BR, Scalisi G, Alkwai S, Rothhammer V, Rotem A, Heyman JA, Thaploo S, Sanmarco LM, Ragoussis J, Weitz DA, Petrecca K, Moffitt JR, Becher B, Antel JP, Prat A, Quintana FJ. MAFG-driven astrocytes promote CNS inflammation. Nature. 2020 02; 578(7796):593-599. PMID: 32051591; PMCID: PMC8049843.
    Citations: 123     Fields:    Translation:HumansAnimalsCells
  18. Chao CC, Gutiérrez-Vázquez C, Rothhammer V, Mayo L, Wheeler MA, Tjon EC, Zandee SEJ, Blain M, de Lima KA, Takenaka MC, Avila-Pacheco J, Hewson P, Liu L, Sanmarco LM, Borucki DM, Lipof GZ, Trauger SA, Clish CB, Antel JP, Prat A, Quintana FJ. Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS. Cell. 2019 12 12; 179(7):1483-1498.e22. PMID: 31813625.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  19. Takenaka MC, Gabriely G, Rothhammer V, Mascanfroni ID, Wheeler MA, Chao CC, Gutiérrez-Vázquez C, Kenison J, Tjon EC, Barroso A, Vandeventer T, de Lima KA, Rothweiler S, Mayo L, Ghannam S, Zandee S, Healy L, Sherr D, Farez MF, Prat A, Antel J, Reardon DA, Zhang H, Robson SC, Getz G, Weiner HL, Quintana FJ. Author Correction: Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39. Nat Neurosci. 2019 Sep; 22(9):1533. PMID: 31197266; PMCID: PMC9811951.
    Citations: 4     Fields:    
  20. Takenaka MC, Gabriely G, Rothhammer V, Mascanfroni ID, Wheeler MA, Chao CC, Gutiérrez-Vázquez C, Kenison J, Tjon EC, Barroso A, Vandeventer T, de Lima KA, Rothweiler S, Mayo L, Ghannam S, Zandee S, Healy L, Sherr D, Farez MF, Prat A, Antel J, Reardon DA, Zhang H, Robson SC, Getz G, Weiner HL, Quintana FJ. Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39. Nat Neurosci. 2019 05; 22(5):729-740. PMID: 30962630; PMCID: PMC8052632.
    Citations: 183     Fields:    Translation:HumansAnimalsCells
  21. Wheeler MA, Jaronen M, Covacu R, Zandee SEJ, Scalisi G, Rothhammer V, Tjon EC, Chao CC, Kenison JE, Blain M, Rao VTS, Hewson P, Barroso A, Gutiérrez-Vázquez C, Prat A, Antel JP, Hauser R, Quintana FJ. Environmental Control of Astrocyte Pathogenic Activities in CNS Inflammation. Cell. 2019 01 24; 176(3):581-596.e18. PMID: 30661753; PMCID: PMC6440749.
    Citations: 59     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  22. Wheeler MA, Quintana FJ. Regulation of Astrocyte Functions in Multiple Sclerosis. Cold Spring Harb Perspect Med. 2019 01 02; 9(1). PMID: 29358321.
    Citations: 45     Fields:    Translation:HumansCells
  23. Rothhammer V, Borucki DM, Tjon EC, Takenaka MC, Chao CC, Ardura-Fabregat A, de Lima KA, Gutiérrez-Vázquez C, Hewson P, Staszewski O, Blain M, Healy L, Neziraj T, Borio M, Wheeler M, Dragin LL, Laplaud DA, Antel J, Alvarez JI, Prinz M, Quintana FJ. Microglial control of astrocytes in response to microbial metabolites. Nature. 2018 05; 557(7707):724-728. PMID: 29769726.
    Citations: 341     Fields:    Translation:HumansAnimalsCells
  24. Wheeler MA, Rothhammer V, Quintana FJ. Control of immune-mediated pathology via the aryl hydrocarbon receptor. J Biol Chem. 2017 07 28; 292(30):12383-12389. PMID: 28615443.
    Citations: 39     Fields:    Translation:HumansAnimals
  25. Smith CJ, Wheeler MA, Marjoram L, Bagnat M, Deppmann CD, Kucenas S. TNFa/TNFR2 signaling is required for glial ensheathment at the dorsal root entry zone. PLoS Genet. 2017 04; 13(4):e1006712. PMID: 28379965; PMCID: PMC5397050.
    Citations: 10     Fields:    Translation:AnimalsCells
  26. Gabriely G, Wheeler MA, Takenaka MC, Quintana FJ. Role of AHR and HIF-1a in Glioblastoma Metabolism. Trends Endocrinol Metab. 2017 06; 28(6):428-436. PMID: 28318896; PMCID: PMC5438779.
    Citations: 44     Fields:    Translation:Humans
  27. Wheeler MA, Smith CJ, Ottolini M, Barker BS, Purohit AM, Grippo RM, Gaykema RP, Spano AJ, Beenhakker MP, Kucenas S, Patel MK, Deppmann CD, Güler AD. Genetically targeted magnetic control of the nervous system. Nat Neurosci. 2016 05; 19(5):756-761. PMID: 26950006.
    Citations: 79     Fields:    Translation:HumansAnimalsCells
  28. Wheeler MA, Heffner DL, Kim S, Espy SM, Spano AJ, Cleland CL, Deppmann CD. TNF-a/TNFR1 signaling is required for the development and function of primary nociceptors. Neuron. 2014 May 07; 82(3):587-602. PMID: 24811380.
    Citations: 39     Fields:    Translation:AnimalsCells
  29. Bonaguidi MA, Wheeler MA, Shapiro JS, Stadel RP, Sun GJ, Ming GL, Song H. In vivo clonal analysis reveals self-renewing and multipotent adult neural stem cell characteristics. Cell. 2011 Jun 24; 145(7):1142-55. PMID: 21664664.
    Citations: 403     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.