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Jaya Rajaiya, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01EY021558 (RAJAIYA, JAYA) Sep 30, 2011 - Jun 30, 2021
    Endocytosis in Adenoviral Ocular Pathogenesis
    Role: Principal Investigator
  2. R01EY013124 (CHODOSH, JAMES) Jul 1, 2000 - Mar 31, 2021
    Immunopathogenesis of Adenovirus Keratitis
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Ismail AM, Lee JS, Lee JY, Singh G, Dyer DW, Seto D, Chodosh J, Rajaiya J. Adenoviromics: Mining the Human Adenovirus Species D Genome. Front Microbiol. 2018; 9:2178. PMID: 30254627.
    View in: PubMed
  2. Lee JY, Lee JS, Materne EC, Rajala R, Ismail AM, Seto D, Dyer DW, Rajaiya J, Chodosh J. Bacterial RecA Protein Promotes Adenoviral Recombination during In Vitro Infection. mSphere. 2018 06 27; 3(3). PMID: 29925671.
    View in: PubMed
  3. Uchino Y, Woodward AM, Mauris J, Peterson K, Verma P, Nilsson UJ, Rajaiya J, Argüeso P. Galectin-3 is an amplifier of the interleukin-1ß-mediated inflammatory response in corneal keratinocytes. Immunology. 2018 Jul; 154(3):490-499. PMID: 29359328.
    View in: PubMed
  4. Ismail AM, Cui T, Dommaraju K, Singh G, Dehghan S, Seto J, Shrivastava S, Fedorova NB, Gupta N, Stockwell TB, Madupu R, Heim A, Kajon AE, Romanowski EG, Kowalski RP, Malathi J, Therese KL, Madhavan HN, Zhang Q, Ferreyra LJ, Jones MS, Rajaiya J, Dyer DW, Chodosh J, Seto D. Genomic analysis of a large set of currently-and historically-important human adenovirus pathogens. Emerg Microbes Infect. 2018 Feb 07; 7(1):10. PMID: 29410402.
    View in: PubMed
  5. Ramke M, Lee JY, Dyer DW, Seto D, Rajaiya J, Chodosh J. The 5'UTR in human adenoviruses: leader diversity in late gene expression. Sci Rep. 2017 04 04; 7(1):618. PMID: 28377580.
    View in: PubMed
  6. Ismail AM, Lee JS, Dyer DW, Seto D, Rajaiya J, Chodosh J. Selection Pressure in the Human Adenovirus Fiber Knob Drives Cell Specificity in Epidemic Keratoconjunctivitis. J Virol. 2016 Nov 01; 90(21):9598-9607. PMID: 27512073.
    View in: PubMed
  7. Yousuf MA, Lee JS, Zhou X, Ramke M, Lee JY, Chodosh J, Rajaiya J. Protein kinase C Signaling in Adenoviral Infection. Biochemistry. 2016 Oct 04. PMID: 27700064.
    View in: PubMed
  8. Zhou X, Ramke M, Chintakuntlawar AV, Lee JY, Rajaiya J, Chodosh J. Role of MyD88 in adenovirus keratitis. Immunol Cell Biol. 2017 01; 95(1):108-116. PMID: 27528076.
    View in: PubMed
  9. Ramke M, Zhou X, Materne EC, Rajaiya J, Chodosh J. Resident corneal c-fms(+) macrophages and dendritic cells mediate early cellular infiltration in adenovirus keratitis. Exp Eye Res. 2016 06; 147:144-147. PMID: 27185163.
    View in: PubMed
  10. Menon BB, Zhou X, Spurr-Michaud S, Rajaiya J, Chodosh J, Gipson IK. Epidemic Keratoconjunctivitis-Causing Adenoviruses Induce MUC16 Ectodomain Release To Infect Ocular Surface Epithelial Cells. mSphere. 2016 Jan-Feb; 1(1). PMID: 27303700; PMCID: PMC4863608.
  11. Singh G, Zhou X, Lee JY, Yousuf MA, Ramke M, Ismail AM, Lee JS, Robinson CM, Seto D, Dyer DW, Jones MS, Rajaiya J, Chodosh J. Recombination of the epsilon determinant and corneal tropism: Human adenovirus species D types 15, 29, 56, and 69. Virology. 2015 Nov; 485:452-9. PMID: 26343864; PMCID: PMC4619159 [Available on 11/01/16].
  12. Rajaiya J, Zhou X, Barequet I, Gilmore MS, Chodosh J. Novel model of innate immunity in corneal infection. In Vitro Cell Dev Biol Anim. 2015 Sep; 51(8):827-34. PMID: 25977076.
    View in: PubMed
  13. Mukherjee S, Zhou X, Rajaiya J, Chodosh J. Ultrastructure of adenovirus keratitis. Invest Ophthalmol Vis Sci. 2015 Jan 06; 56(1):472-7. PMID: 25564451; PMCID: PMC4299469.
  14. Yousuf MA, Zhou X, Mukherjee S, Chintakuntlawar AV, Lee JY, Ramke M, Chodosh J, Rajaiya J. Caveolin-1 associated adenovirus entry into human corneal cells. PLoS One. 2013; 8(10):e77462. PMID: 24147000; PMCID: PMC3795695.
  15. Robinson CM, Zhou X, Rajaiya J, Yousuf MA, Singh G, DeSerres JJ, Walsh MP, Wong S, Seto D, Dyer DW, Chodosh J, Jones MS. Predicting the next eye pathogen: analysis of a novel adenovirus. MBio. 2013 Apr 09; 4(2):e00595-12. PMID: 23572555; PMCID: PMC3622935.
  16. Robinson CM, Singh G, Lee JY, Dehghan S, Rajaiya J, Liu EB, Yousuf MA, Betensky RA, Jones MS, Dyer DW, Seto D, Chodosh J. Molecular evolution of human adenoviruses. Sci Rep. 2013; 3:1812. PMID: 23657240; PMCID: PMC3648800.
  17. Rajaiya J, Yousuf MA, Singh G, Stanish H, Chodosh J. Heat shock protein 27 mediated signaling in viral infection. Biochemistry. 2012 Jul 17; 51(28):5695-702. PMID: 22734719; PMCID: PMC3680509.
  18. Zhou X, Robinson CM, Rajaiya J, Dehghan S, Seto D, Jones MS, Dyer DW, Chodosh J. Analysis of human adenovirus type 19 associated with epidemic keratoconjunctivitis and its reclassification as adenovirus type 64. Invest Ophthalmol Vis Sci. 2012 May 14; 53(6):2804-11. PMID: 22467570; PMCID: PMC3367469.
  19. Robinson CM, Rajaiya J, Zhou X, Singh G, Dyer DW, Chodosh J. The E3 CR1-gamma gene in human adenoviruses associated with epidemic keratoconjunctivitis. Virus Res. 2011 Sep; 160(1-2):120-7. PMID: 21683743; PMCID: PMC3163711.
  20. Chintakuntlawar AV, Zhou X, Rajaiya J, Chodosh J. Viral capsid is a pathogen-associated molecular pattern in adenovirus keratitis. PLoS Pathog. 2010 Apr 15; 6(4):e1000841. PMID: 20419141; PMCID: PMC2855317.
  21. Rajaiya J, Sadeghi N, Chodosh J. Specific NFkappaB subunit activation and kinetics of cytokine induction in adenoviral keratitis. Mol Vis. 2009 Dec 25; 15:2879-89. PMID: 20038977; PMCID: PMC2797044.
  22. Robinson CM, Rajaiya J, Walsh MP, Seto D, Dyer DW, Jones MS, Chodosh J. Computational analysis of human adenovirus type 22 provides evidence for recombination among species D human adenoviruses in the penton base gene. J Virol. 2009 Sep; 83(17):8980-5. PMID: 19553309; PMCID: PMC2738150.
  23. Rajaiya J, Xiao J, Rajala RV, Chodosh J. Human adenovirus type 19 infection of corneal cells induces p38 MAPK-dependent interleukin-8 expression. Virol J. 2008 Jan 25; 5:17. PMID: 18221537; PMCID: PMC2265692.
  24. Rajaiya J, Chodosh J. New paradigms in infectious eye disease: adenoviral keratoconjunctivitis. Arch Soc Esp Oftalmol. 2006 Sep; 81(9):493-8. PMID: 17016780.
    View in: PubMed
  25. Rajaiya J, Nixon JC, Ayers N, Desgranges ZP, Roy AL, Webb CF. Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-I. Mol Cell Biol. 2006 Jun; 26(12):4758-68. PMID: 16738337; PMCID: PMC1489113.
  26. Rajaiya J, Hatfield M, Nixon JC, Rawlings DJ, Webb CF. Bruton's tyrosine kinase regulates immunoglobulin promoter activation in association with the transcription factor Bright. Mol Cell Biol. 2005 Mar; 25(6):2073-84. PMID: 15743806; PMCID: PMC1061591.
  27. Nixon JC, Rajaiya J, Webb CF. Mutations in the DNA-binding domain of the transcription factor Bright act as dominant negative proteins and interfere with immunoglobulin transactivation. J Biol Chem. 2004 Dec 10; 279(50):52465-72. PMID: 15456761.
    View in: PubMed
  28. Nixon JC, Rajaiya JB, Ayers N, Evetts S, Webb CF. The transcription factor, Bright, is not expressed in all human B lymphocyte subpopulations. Cell Immunol. 2004 Mar; 228(1):42-53. PMID: 15203319.
    View in: PubMed
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.