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Jaya Rajaiya, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01EY021558 (RAJAIYA, JAYA) Sep 30, 2011 - Jun 30, 2021
    NIH/NEI
    Endocytosis in Adenoviral Ocular Pathogenesis
    Role: Principal Investigator
  2. R01EY013124 (CHODOSH, JAMES) Jul 1, 2000 - Mar 31, 2021
    NIH/NEI
    Immunopathogenesis of Adenovirus Keratitis
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Singh G, Ismail AM, Lee JY, Ramke M, Lee JS, Dyer DW, Seto D, Rajaiya J, Chodosh J. Divergent Evolution of E1A CR3 in Human Adenovirus Species D. Viruses. 2019 Feb 08; 11(2). PMID: 30744049.
    Citations:    
  2. Lee JS, Ismail AM, Lee JY, Zhou X, Materne EC, Chodosh J, Rajaiya J. Impact of dynamin 2 on adenovirus nuclear entry. Virology. 2019 Mar; 529:43-56. PMID: 30660774.
    Citations:    Fields:    
  3. Ismail AM, Cui T, Dommaraju K, Singh G, Dehghan S, Seto J, Shrivastava S, Fedorova NB, Gupta N, Stockwell TB, Halpin R, Madupu R, Heim A, Kajon AE, Romanowski EG, Kowalski RP, Malathi J, Therese KL, Madhavan HN, Zhang Q, Ferreyra LJ, Jones MS, Rajaiya J, Dyer DW, Chodosh J, Seto D. Author Correction: Genomic analysis of a large set of currently-and historically-important human adenovirus pathogens. Emerg Microbes Infect. 2018 Dec 08; 7(1):208. PMID: 30532034.
    Citations:    Fields:    
  4. Ismail AM, Lee JS, Lee JY, Singh G, Dyer DW, Seto D, Chodosh J, Rajaiya J. Corrigendum: Adenoviromics: Mining the Human Adenovirus Species D Genome. Front Microbiol. 2018; 9:3005. PMID: 30555456.
    Citations:    
  5. Pan H, Yan Y, Zhang J, Zhao S, Feng L, Ou J, Cao N, Li M, Zhao W, Wan C, Ismail AM, Rajaiya J, Chodosh J, Zhang Q. Rapid Construction of a Replication-Competent Infectious Clone of Human Adenovirus Type 14 by Gibson Assembly. Viruses. 2018 10 18; 10(10). PMID: 30340336.
    Citations:    Fields:    Translation:HumansCells
  6. Ismail AM, Lee JS, Lee JY, Singh G, Dyer DW, Seto D, Chodosh J, Rajaiya J. Adenoviromics: Mining the Human Adenovirus Species D Genome. Front Microbiol. 2018; 9:2178. PMID: 30254627.
    Citations:    
  7. Lee JY, Lee JS, Materne EC, Rajala R, Ismail AM, Seto D, Dyer DW, Rajaiya J, Chodosh J. Bacterial RecA Protein Promotes Adenoviral Recombination during In Vitro Infection. mSphere. 2018 06 27; 3(3). PMID: 29925671.
    Citations:    Translation:HumansCells
  8. Uchino Y, Woodward AM, Mauris J, Peterson K, Verma P, Nilsson UJ, Rajaiya J, Argüeso P. Galectin-3 is an amplifier of the interleukin-1ß-mediated inflammatory response in corneal keratinocytes. Immunology. 2018 Jul; 154(3):490-499. PMID: 29359328.
    Citations: 2     Fields:    
  9. Ismail AM, Cui T, Dommaraju K, Singh G, Dehghan S, Seto J, Shrivastava S, Fedorova NB, Gupta N, Stockwell TB, Halpin R, Madupu R, Heim A, Kajon AE, Romanowski EG, Kowalski RP, Malathi J, Therese KL, Madhavan HN, Zhang Q, Ferreyra LJ, Jones MS, Rajaiya J, Dyer DW, Chodosh J, Seto D. Genomic analysis of a large set of currently-and historically-important human adenovirus pathogens. Emerg Microbes Infect. 2018 Feb 07; 7(1):10. PMID: 29410402.
    Citations: 1     Fields:    Translation:HumansCells
  10. Ramke M, Lee JY, Dyer DW, Seto D, Rajaiya J, Chodosh J. The 5'UTR in human adenoviruses: leader diversity in late gene expression. Sci Rep. 2017 04 04; 7(1):618. PMID: 28377580.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  11. Ismail AM, Lee JS, Dyer DW, Seto D, Rajaiya J, Chodosh J. Selection Pressure in the Human Adenovirus Fiber Knob Drives Cell Specificity in Epidemic Keratoconjunctivitis. J Virol. 2016 Nov 01; 90(21):9598-9607. PMID: 27512073.
    Citations: 1     Fields:    Translation:HumansCells
  12. Yousuf MA, Lee JS, Zhou X, Ramke M, Lee JY, Chodosh J, Rajaiya J. Protein Kinase C Signaling in Adenoviral Infection. Biochemistry. 2016 Oct 25; 55(42):5938-5946. PMID: 27700064.
    Citations: 1     Fields:    
  13. Zhou X, Ramke M, Chintakuntlawar AV, Lee JY, Rajaiya J, Chodosh J. Role of MyD88 in adenovirus keratitis. Immunol Cell Biol. 2017 01; 95(1):108-116. PMID: 27528076.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  14. Ramke M, Zhou X, Materne EC, Rajaiya J, Chodosh J. Resident corneal c-fms(+) macrophages and dendritic cells mediate early cellular infiltration in adenovirus keratitis. Exp Eye Res. 2016 06; 147:144-147. PMID: 27185163.
    Citations: 2     Fields:    Translation:AnimalsCells
  15. Menon BB, Zhou X, Spurr-Michaud S, Rajaiya J, Chodosh J, Gipson IK. Epidemic Keratoconjunctivitis-Causing Adenoviruses Induce MUC16 Ectodomain Release To Infect Ocular Surface Epithelial Cells. mSphere. 2016 Jan-Feb; 1(1). PMID: 27303700; PMCID: PMC4863608.
    Citations: 2     
  16. Singh G, Zhou X, Lee JY, Yousuf MA, Ramke M, Ismail AM, Lee JS, Robinson CM, Seto D, Dyer DW, Jones MS, Rajaiya J, Chodosh J. Recombination of the epsilon determinant and corneal tropism: Human adenovirus species D types 15, 29, 56, and 69. Virology. 2015 Nov; 485:452-9. PMID: 26343864; PMCID: PMC4619159.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  17. Rajaiya J, Zhou X, Barequet I, Gilmore MS, Chodosh J. Novel model of innate immunity in corneal infection. In Vitro Cell Dev Biol Anim. 2015 Sep; 51(8):827-34. PMID: 25977076.
    Citations: 3     Fields:    Translation:HumansCells
  18. Mukherjee S, Zhou X, Rajaiya J, Chodosh J. Ultrastructure of adenovirus keratitis. Invest Ophthalmol Vis Sci. 2015 Jan 06; 56(1):472-7. PMID: 25564451; PMCID: PMC4299469.
    Citations: 4     Fields:    Translation:AnimalsCells
  19. Yousuf MA, Zhou X, Mukherjee S, Chintakuntlawar AV, Lee JY, Ramke M, Chodosh J, Rajaiya J. Caveolin-1 associated adenovirus entry into human corneal cells. PLoS One. 2013; 8(10):e77462. PMID: 24147000.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  20. Robinson CM, Zhou X, Rajaiya J, Yousuf MA, Singh G, DeSerres JJ, Walsh MP, Wong S, Seto D, Dyer DW, Chodosh J, Jones MS. Predicting the next eye pathogen: analysis of a novel adenovirus. MBio. 2013 Apr 09; 4(2):e00595-12. PMID: 23572555; PMCID: PMC3622935.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  21. Robinson CM, Singh G, Lee JY, Dehghan S, Rajaiya J, Liu EB, Yousuf MA, Betensky RA, Jones MS, Dyer DW, Seto D, Chodosh J. Molecular evolution of human adenoviruses. Sci Rep. 2013; 3:1812. PMID: 23657240; PMCID: PMC3648800.
    Citations: 39     Fields:    Translation:HumansCells
  22. Rajaiya J, Yousuf MA, Singh G, Stanish H, Chodosh J. Heat shock protein 27 mediated signaling in viral infection. Biochemistry. 2012 Jul 17; 51(28):5695-702. PMID: 22734719; PMCID: PMC3680509.
    Citations: 3     Fields:    Translation:HumansCells
  23. Zhou X, Robinson CM, Rajaiya J, Dehghan S, Seto D, Jones MS, Dyer DW, Chodosh J. Analysis of human adenovirus type 19 associated with epidemic keratoconjunctivitis and its reclassification as adenovirus type 64. Invest Ophthalmol Vis Sci. 2012 May 14; 53(6):2804-11. PMID: 22467570; PMCID: PMC3367469.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  24. Robinson CM, Rajaiya J, Zhou X, Singh G, Dyer DW, Chodosh J. The E3 CR1-gamma gene in human adenoviruses associated with epidemic keratoconjunctivitis. Virus Res. 2011 Sep; 160(1-2):120-7. PMID: 21683743; PMCID: PMC3163711.
    Citations: 6     Fields:    Translation:HumansCells
  25. Chintakuntlawar AV, Zhou X, Rajaiya J, Chodosh J. Viral capsid is a pathogen-associated molecular pattern in adenovirus keratitis. PLoS Pathog. 2010 Apr 15; 6(4):e1000841. PMID: 20419141; PMCID: PMC2855317.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  26. Rajaiya J, Sadeghi N, Chodosh J. Specific NFkappaB subunit activation and kinetics of cytokine induction in adenoviral keratitis. Mol Vis. 2009 Dec 25; 15:2879-89. PMID: 20038977; PMCID: PMC2797044.
    Citations: 12     Fields:    Translation:HumansCells
  27. Robinson CM, Rajaiya J, Walsh MP, Seto D, Dyer DW, Jones MS, Chodosh J. Computational analysis of human adenovirus type 22 provides evidence for recombination among species D human adenoviruses in the penton base gene. J Virol. 2009 Sep; 83(17):8980-5. PMID: 19553309; PMCID: PMC2738150.
    Citations: 29     Fields:    Translation:HumansCells
  28. Rajaiya J, Xiao J, Rajala RV, Chodosh J. Human adenovirus type 19 infection of corneal cells induces p38 MAPK-dependent interleukin-8 expression. Virol J. 2008 Jan 25; 5:17. PMID: 18221537; PMCID: PMC2265692.
    Citations: 20     Fields:    Translation:HumansCells
  29. Rajaiya J, Chodosh J. New paradigms in infectious eye disease: adenoviral keratoconjunctivitis. Arch Soc Esp Oftalmol. 2006 Sep; 81(9):493-8. PMID: 17016780.
    Citations: 3     Fields:    Translation:Humans
  30. Rajaiya J, Nixon JC, Ayers N, Desgranges ZP, Roy AL, Webb CF. Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-I. Mol Cell Biol. 2006 Jun; 26(12):4758-68. PMID: 16738337; PMCID: PMC1489113.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  31. Rajaiya J, Hatfield M, Nixon JC, Rawlings DJ, Webb CF. Bruton's tyrosine kinase regulates immunoglobulin promoter activation in association with the transcription factor Bright. Mol Cell Biol. 2005 Mar; 25(6):2073-84. PMID: 15743806; PMCID: PMC1061591.
    Citations: 18     Fields:    Translation:AnimalsCells
  32. Nixon JC, Rajaiya J, Webb CF. Mutations in the DNA-binding domain of the transcription factor Bright act as dominant negative proteins and interfere with immunoglobulin transactivation. J Biol Chem. 2004 Dec 10; 279(50):52465-72. PMID: 15456761.
    Citations: 15     Fields:    Translation:AnimalsCells
  33. Nixon JC, Rajaiya JB, Ayers N, Evetts S, Webb CF. The transcription factor, Bright, is not expressed in all human B lymphocyte subpopulations. Cell Immunol. 2004 Mar; 228(1):42-53. PMID: 15203319.
    Citations: 12     Fields:    Translation:HumansCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.