Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Last Name

profileJi-Kyung Choi, PH.D.

TitleInstructor in Radiology
InstitutionMassachusetts General Hospital
AddressMassachusetts General Hospital
Room 2301, NMR Center
149 13th Street
Charlestown MA 02129
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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R21NS059644     (CHOI, JI-KYUNG)May 15, 2009 - Jan 30, 2012
Functional and Chemical Markers for ALS Progression
Role: Principal Investigator

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Jenkins BG, Zhu A, Poutiainen P, Choi JK, Kil KE, Zhang Z, Kuruppu D, Aytan N, Dedeoglu A, Brownell AL. Functional modulation of G-protein coupled receptors during Parkinson disease-like neurodegeneration. Neuropharmacology. 2016 Sep; 108:462-73. PMID: 26581500; PMCID: PMC4896842 [Available on 09/01/17].
  2. Kil KE, Poutiainen P, Zhang Z, Zhu A, Kuruppu D, Prabhakar S, Choi JK, Tannous BA, Brownell AL. Synthesis and evaluation of N-(methylthiophenyl)picolinamide derivatives as PET radioligands for metabotropic glutamate receptor subtype 4. Bioorg Med Chem Lett. 2016 Jan 01; 26(1):133-9. PMID: 26602273; PMCID: PMC4684791 [Available on 01/01/17].
  3. Arsenault D, Coulombe K, Zhu A, Gong C, Kil KE, Choi JK, Poutiainen P, Brownell AL. Loss of Metabotropic Glutamate Receptor 5 Function on Peripheral Benzodiazepine Receptor in Mice Prenatally Exposed to LPS. PLoS One. 2015; 10(11):e0142093. PMID: 26536027; PMCID: PMC4633140.
  4. Choi JK, Zhu A, Jenkins BG, Hattori S, Kil KE, Takagi T, Ishii S, Miyakawa T, Brownell AL. Combined behavioral studies and in vivo imaging of inflammatory response and expression of mGlu5 receptors in schnurri-2 knockout mice. Neurosci Lett. 2015 Nov 16; 609:159-64. PMID: 26483320.
    View in: PubMed
  5. Zhang Z, Kil KE, Poutiainen P, Choi JK, Kang HJ, Huang XP, Roth BL, Brownell AL. Re-exploring the N-phenylpicolinamide derivatives to develop mGlu4 ligands with improved affinity and in vitro microsomal stability. Bioorg Med Chem Lett. 2015 Sep 15; 25(18):3956-60. PMID: 26231155; PMCID: PMC4539532.
  6. Kil KE, Poutiainen P, Zhang Z, Zhu A, Choi JK, Jokivarsi K, Brownell AL. Radiosynthesis and evaluation of an 18F-labeled positron emission tomography (PET) radioligand for metabotropic glutamate receptor subtype 4 (mGlu4). J Med Chem. 2014 Nov 13; 57(21):9130-8. PMID: 25330258; PMCID: PMC4230996.
  7. Choi JK, Carreras I, Aytan N, Jenkins-Sahlin E, Dedeoglu A, Jenkins BG. The effects of aging, housing and ibuprofen treatment on brain neurochemistry in a triple transgene Alzheimer's disease mouse model using magnetic resonance spectroscopy and imaging. Brain Res. 2014 Nov 24; 1590:85-96. PMID: 25301691; PMCID: PMC4274938.
  8. Kil KE, Zhu A, Zhang Z, Choi JK, Kura S, Gong C, Brownell AL. Development of [(123)I]IPEB and [(123)I]IMPEB as SPECT Radioligands for Metabotropic Glutamate Receptor Subtype 5. ACS Med Chem Lett. 2014 Jun 12; 5(6):652-6. PMID: 24944738; PMCID: PMC4060925.
  9. Arsenault D, Zhu A, Gong C, Kil KE, Kura S, Choi JK, Brownell AL. Hypo-anxious phenotype of adolescent offspring prenatally exposed to LPS is associated with reduced mGluR5 expression in hippocampus. Open J Med Psychol. 2014 Apr; 3(3):202-211. PMID: 25419490.
    View in: PubMed
  10. Korkmaz OT, Aytan N, Carreras I, Choi JK, Kowall NW, Jenkins BG, Dedeoglu A. 7,8-Dihydroxyflavone improves motor performance and enhances lower motor neuronal survival in a mouse model of amyotrophic lateral sclerosis. Neurosci Lett. 2014 Apr 30; 566:286-91. PMID: 24637017.
    View in: PubMed
  11. Carreras I, McKee AC, Choi JK, Aytan N, Kowall NW, Jenkins BG, Dedeoglu A. R-flurbiprofen improves tau, but not Aß pathology in a triple transgenic model of Alzheimer's disease. Brain Res. 2013 Dec 06; 1541:115-27. PMID: 24161403; PMCID: PMC3863610.
  12. Aytan N, Choi JK, Carreras I, Kowall NW, Jenkins BG, Dedeoglu A. Combination therapy in a transgenic model of Alzheimer's disease. Exp Neurol. 2013 Dec; 250:228-238. PMID: 24120437; PMCID: PMC3926203.
  13. Satpute AB, Wager TD, Cohen-Adad J, Bianciardi M, Choi JK, Buhle JT, Wald LL, Barrett LF. Identification of discrete functional subregions of the human periaqueductal gray. Proc Natl Acad Sci U S A. 2013 Oct 15; 110(42):17101-6. PMID: 24082116; PMCID: PMC3801046.
  14. Kil KE, Zhang Z, Jokivarsi K, Gong C, Choi JK, Kura S, Brownell AL. Radiosynthesis of N-(4-chloro-3-[(11)C]methoxyphenyl)-2-picolinamide ([(11)C]ML128) as a PET radiotracer for metabotropic glutamate receptor subtype 4 (mGlu4). Bioorg Med Chem. 2013 Oct 01; 21(19):5955-62. PMID: 23978356; PMCID: PMC3811911.
  15. Chen YI, Famous K, Xu H, Choi JK, Mandeville JB, Schmidt HD, Pierce RC, Jenkins BG. Cocaine self-administration leads to alterations in temporal responses to cocaine challenge in limbic and motor circuitry. Eur J Neurosci. 2011 Sep; 34(5):800-15. PMID: 21896062; PMCID: PMC3172610.
  16. Mandeville JB, Choi JK, Jarraya B, Rosen BR, Jenkins BG, Vanduffel W. fMRI of cocaine self-administration in macaques reveals functional inhibition of basal ganglia. Neuropsychopharmacology. 2011 May; 36(6):1187-98. PMID: 21307843; PMCID: PMC3079280.
  17. Choi JK, Mandeville JB, Chen YI, Grundt P, Sarkar SK, Newman AH, Jenkins BG. Imaging brain regional and cortical laminar effects of selective D3 agonists and antagonists. Psychopharmacology (Berl). 2010 Sep; 212(1):59-72. PMID: 20628733; PMCID: PMC3822611.
  18. Chen YI, Choi JK, Xu H, Ren J, Andersen SL, Jenkins BG. Pharmacologic neuroimaging of the ontogeny of dopamine receptor function. Dev Neurosci. 2010 Jul; 32(2):125-38. PMID: 20523024; PMCID: PMC2919511.
  19. Choi JK, Carreras I, Dedeoglu A, Jenkins BG. Detection of increased scyllo-inositol in brain with magnetic resonance spectroscopy after dietary supplementation in Alzheimer's disease mouse models. Neuropharmacology. 2010 Sep-Oct; 59(4-5):353-7. PMID: 20399219; PMCID: PMC2926267.
  20. Choi JK, Dedeoglu A, Jenkins BG. Longitudinal monitoring of motor neuron circuitry in FALS rats using in-vivo phMRI. Neuroreport. 2010 Feb 17; 21(3):157-62. PMID: 20118741; PMCID: PMC2848450.
  21. Carreras I, Yuruker S, Aytan N, Hossain L, Choi JK, Jenkins BG, Kowall NW, Dedeoglu A. Moderate exercise delays the motor performance decline in a transgenic model of ALS. Brain Res. 2010 Feb 08; 1313:192-201. PMID: 19968977; PMCID: PMC2892864.
  22. Choi JK, Küstermann E, Dedeoglu A, Jenkins BG. Magnetic resonance spectroscopy of regional brain metabolite markers in FALS mice and the effects of dietary creatine supplementation. Eur J Neurosci. 2009 Dec; 30(11):2143-50. PMID: 19930399; PMCID: PMC2846694.
  23. Ren J, Xu H, Choi JK, Jenkins BG, Chen YI. Dopaminergic response to graded dopamine concentration elicited by four amphetamine doses. Synapse. 2009 Sep; 63(9):764-72. PMID: 19484725; PMCID: PMC2758079.
  24. Choi JK, Jenkins BG, Carreras I, Kaymakcalan S, Cormier K, Kowall NW, Dedeoglu A. Anti-inflammatory treatment in AD mice protects against neuronal pathology. Exp Neurol. 2010 Jun; 223(2):377-84. PMID: 19679126; PMCID: PMC2864355.
  25. Astradsson A, Jenkins BG, Choi JK, Hallett PJ, Levesque MA, McDowell JS, Brownell AL, Spealman RD, Isacson O. The blood-brain barrier is intact after levodopa-induced dyskinesias in parkinsonian primates--evidence from in vivo neuroimaging studies. Neurobiol Dis. 2009 Sep; 35(3):348-51. PMID: 19501164; PMCID: PMC3319396.
  26. Grundt P, Prevatt KM, Cao J, Taylor M, Floresca CZ, Choi JK, Jenkins BG, Luedtke RR, Newman AH. Heterocyclic analogues of N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)arylcarboxamides with functionalized linking chains as novel dopamine D3 receptor ligands: potential substance abuse therapeutic agents. J Med Chem. 2007 Aug 23; 50(17):4135-46. PMID: 17672446.
    View in: PubMed
  27. Sánchez-Pernaute R, Jenkins BG, Choi JK, Iris Chen YC, Isacson O. In vivo evidence of D3 dopamine receptor sensitization in parkinsonian primates and rodents with l-DOPA-induced dyskinesias. Neurobiol Dis. 2007 Aug; 27(2):220-7. PMID: 17588764; PMCID: PMC2674779.
  28. Choi JK, Dedeoglu A, Jenkins BG. Application of MRS to mouse models of neurodegenerative illness. NMR Biomed. 2007 May; 20(3):216-37. PMID: 17451183.
    View in: PubMed
  29. Choi JK, Mandeville JB, Chen YI, Kim YR, Jenkins BG. High resolution spatial mapping of nicotine action using pharmacologic magnetic resonance imaging. Synapse. 2006 Aug; 60(2):152-7. PMID: 16715493.
    View in: PubMed
  30. Choi JK, Chen YI, Hamel E, Jenkins BG. Brain hemodynamic changes mediated by dopamine receptors: Role of the cerebral microvasculature in dopamine-mediated neurovascular coupling. Neuroimage. 2006 Apr 15; 30(3):700-12. PMID: 16459104.
    View in: PubMed
  31. Chen YC, Choi JK, Andersen SL, Rosen BR, Jenkins BG. Mapping dopamine D2/D3 receptor function using pharmacological magnetic resonance imaging. Psychopharmacology (Berl). 2005 Aug; 180(4):705-15. PMID: 15536545.
    View in: PubMed
  32. Chen YI, Choi JK, Jenkins BG. Mapping interactions between dopamine and adenosine A2a receptors using pharmacologic MRI. Synapse. 2005 Feb; 55(2):80-8. PMID: 15529335.
    View in: PubMed
  33. Mandeville JB, Jenkins BG, Chen YC, Choi JK, Kim YR, Belen D, Liu C, Kosofsky BE, Marota JJ. Exogenous contrast agent improves sensitivity of gradient-echo functional magnetic resonance imaging at 9.4 T. Magn Reson Med. 2004 Dec; 52(6):1272-81. PMID: 15562489.
    View in: PubMed
  34. Dedeoglu A, Choi JK, Cormier K, Kowall NW, Jenkins BG. Magnetic resonance spectroscopic analysis of Alzheimer's disease mouse brain that express mutant human APP shows altered neurochemical profile. Brain Res. 2004 Jun 25; 1012(1-2):60-5. PMID: 15158161.
    View in: PubMed
  35. Blood AJ, Flaherty AW, Choi JK, Hochberg FH, Greve DN, Bonmassar G, Rosen BR, Jenkins BG. Basal ganglia activity remains elevated after movement in focal hand dystonia. Ann Neurol. 2004 May; 55(5):744-8. PMID: 15122718.
    View in: PubMed
  36. Choi JK, Ho J, Curry S, Qin D, Bittman R, Hamilton JA. Interactions of very long-chain saturated fatty acids with serum albumin. J Lipid Res. 2002 Jul; 43(7):1000-10. PMID: 12091483.
    View in: PubMed
  37. Guo W, Choi JK, Kirkland JL, Corkey BE, Hamilton JA. Esterification of free fatty acids in adipocytes: a comparison between octanoate and oleate. Biochem J. 2000 Jul 15; 349(Pt 2):463-71. PMID: 10880345; PMCID: PMC1221169.
  38. Guo W, Choi JK, Kirkland JL, Corkey BE, Hamilton JA. Incorporation of [1-13C]oleate into cellular triglycerides in differentiating 3T3L1 cells. Lipids. 1999 Aug; 34(8):825-31. PMID: 10529093.
    View in: PubMed
  39. Straub JE, Choi JK . Extracting the energy barrier distribution of a disordered system from the instantaneous normal mode density of states and its application to peptides and proteins. J Phys Chem. 1994; 98:10978-10987.
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