Harvard Catalyst Profiles

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Xiangkun Han, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Zhang W, Gao Y, Li P, Shi Z, Guo T, Li F, Han X, Feng Y, Zheng C, Wang Z, Li F, Chen H, Zhou Z, Zhang L, Ji H. Author Corrections: VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex. Cell Res. 2021 Oct; 31(10):1137. PMID: 34381184; PMCID: PMC8486769.
    Citations: 1     Fields:    
  2. Wang X, Wang Y, Fang Z, Wang H, Zhang J, Zhang L, Huang H, Jiang Z, Jin Y, Han X, Hou S, Zhou B, Meng F, Chen L, Wong KK, Liu J, Zhang Z, Zhang X, Chen H, Sun Y, Hu L, Ji H. Targeting HSPA1A in ARID2-deficient lung adenocarcinoma. Natl Sci Rev. 2021 Oct; 8(10):nwab014. PMID: 34858604.
    Citations: 3     
  3. Yao S, Huang HY, Han X, Ye Y, Qin Z, Zhao G, Li F, Hu G, Hu L, Ji H. Keratin 14-high subpopulation mediates lung cancer metastasis potentially through Gkn1 upregulation. Oncogene. 2019 09; 38(36):6354-6369. PMID: 31320708.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  4. Chen H, Liu T, Holt WV, Yang P, Zhang L, Zhang L, Han X, Bian X, Chen Q. Advances in understanding mechanisms of long-term sperm storage-the soft-shelled turtle model. Histol Histopathol. 2020 Jan; 35(1):1-23. PMID: 31290136.
    Citations:    Fields:    Translation:AnimalsCells
  5. Wang Y, Zhang J, Ren S, Sun D, Huang HY, Wang H, Jin Y, Li F, Zheng C, Yang L, Deng L, Jiang Z, Jiang T, Han X, Hou S, Guo C, Li F, Gao D, Qin J, Gao D, Chen L, Lin SH, Wong KK, Li C, Hu L, Zhou C, Ji H. Branched-Chain Amino Acid Metabolic Reprogramming Orchestrates Drug Resistance to EGFR Tyrosine Kinase Inhibitors. Cell Rep. 2019 07 09; 28(2):512-525.e6. PMID: 31291585.
    Citations: 34     Fields:    Translation:Humans
  6. Hou S, Zhou S, Qin Z, Yang L, Han X, Yao S, Ji H. Evidence, Mechanism, and Clinical Relevance of the Transdifferentiation from Lung Adenocarcinoma to Squamous Cell Carcinoma. Am J Pathol. 2017 May; 187(5):954-962. PMID: 28284717.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  7. Xue Y, Hou S, Ji H, Han X. Evolution from genetics to phenotype: reinterpretation of NSCLC plasticity, heterogeneity, and drug resistance. Protein Cell. 2017 03; 8(3):178-190. PMID: 27757846.
    Citations: 10     Fields:    Translation:Humans
  8. Li F, Fang Z, Zhang J, Li C, Liu H, Xia J, Zhu H, Guo C, Qin Z, Li F, Han X, Wang Y, Feng Y, Wang Y, Zhang W, Wang Z, Jin Y, Sun Y, Wei W, Zeng R, Chen H, Ji H. Identification of TRA2B-DNAH5 fusion as a novel oncogenic driver in human lung squamous cell carcinoma. Cell Res. 2016 Oct; 26(10):1149-1164. PMID: 27670699; PMCID: PMC5113306.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  9. Hou S, Han X, Ji H. Squamous Transition of Lung Adenocarcinoma and Drug Resistance. Trends Cancer. 2016 09; 2(9):463-466. PMID: 28741476.
    Citations: 12     Fields:    Translation:HumansAnimals
  10. Zhang W, Gao Y, Li F, Tong X, Ren Y, Han X, Yao S, Long F, Yang Z, Fan H, Zhang L, Ji H. YAP promotes malignant progression of Lkb1-deficient lung adenocarcinoma through downstream regulation of survivin. Cancer Res. 2015 Nov 01; 75(21):4450-7. PMID: 26363011.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  11. Li F, Han X, Li F, Wang R, Wang H, Gao Y, Wang X, Fang Z, Zhang W, Yao S, Tong X, Wang Y, Feng Y, Sun Y, Li Y, Wong KK, Zhai Q, Chen H, Ji H. LKB1 Inactivation Elicits a Redox Imbalance to Modulate Non-small Cell Lung Cancer Plasticity and Therapeutic Response. Cancer Cell. 2015 May 11; 27(5):698-711. PMID: 25936644; PMCID: PMC4746728.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  12. Gao Y, Zhang W, Han X, Li F, Wang X, Wang R, Fang Z, Tong X, Yao S, Li F, Feng Y, Sun Y, Hou Y, Yang Z, Guan K, Chen H, Zhang L, Ji H. YAP inhibits squamous transdifferentiation of Lkb1-deficient lung adenocarcinoma through ZEB2-dependent DNp63 repression. Nat Commun. 2014 Aug 13; 5:4629. PMID: 25115923.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  13. Fang R, Zheng C, Sun Y, Han X, Gao B, Li C, Liu H, Wong KK, Liu XY, Chen H, Ji H. Integrative genomic analysis reveals a high frequency of LKB1 genetic alteration in Chinese lung adenocarcinomas. J Thorac Oncol. 2014 Feb; 9(2):254-8. PMID: 24419424.
    Citations: 11     Fields:    Translation:Humans
  14. Zhang W, Gao Y, Li P, Shi Z, Guo T, Li F, Han X, Feng Y, Zheng C, Wang Z, Li F, Chen H, Zhou Z, Zhang L, Ji H. VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex. Cell Res. 2014 Mar; 24(3):331-43. PMID: 24458094; PMCID: PMC3945886.
    Citations: 134     Fields:    Translation:HumansAnimalsCells
  15. Han X, Li F, Fang Z, Gao Y, Li F, Fang R, Yao S, Sun Y, Li L, Zhang W, Ma H, Xiao Q, Ge G, Fang J, Wang H, Zhang L, Wong KK, Chen H, Hou Y, Ji H. Transdifferentiation of lung adenocarcinoma in mice with Lkb1 deficiency to squamous cell carcinoma. Nat Commun. 2014; 5:3261. PMID: 24531128; PMCID: PMC3929783.
    Citations: 83     Fields:    Translation:HumansAnimalsCells
  16. Li F, Feng Y, Fang R, Fang Z, Xia J, Han X, Liu XY, Chen H, Liu H, Ji H. Identification of RET gene fusion by exon array analyses in "pan-negative" lung cancer from never smokers. Cell Res. 2012 May; 22(5):928-31. PMID: 22349463.
    Citations: 33     Fields:    Translation:Humans
  17. Li C, Sun Y, Fang R, Han X, Luo X, Wang R, Pan Y, Hu H, Zhang Y, Pao W, Shen L, Ji H, Chen H. Lung adenocarcinomas with HER2-activating mutations are associated with distinct clinical features and HER2/EGFR copy number gains. J Thorac Oncol. 2012 Jan; 7(1):85-9. PMID: 22071781.
    Citations: 37     Fields:    Translation:Humans
  18. Li C, Fang R, Sun Y, Han X, Li F, Gao B, Iafrate AJ, Liu XY, Pao W, Chen H, Ji H. Spectrum of oncogenic driver mutations in lung adenocarcinomas from East Asian never smokers. PLoS One. 2011; 6(11):e28204. PMID: 22140546; PMCID: PMC3227646.
    Citations: 92     Fields:    Translation:HumansCells
  19. Li C, Sun Y, Fang Z, Han X, Fang R, Zhang Y, Pan Y, Zhang W, Ren Y, Ji H, Chen H. Comprehensive analysis of epidermal growth factor receptor gene status in lung adenocarcinoma. J Thorac Oncol. 2011 Jun; 6(6):1016-21. PMID: 21532505.
    Citations: 4     Fields:    Translation:Humans
  20. Gao Y, Xiao Q, Ma H, Li L, Liu J, Feng Y, Fang Z, Wu J, Han X, Zhang J, Sun Y, Wu G, Padera R, Chen H, Wong KK, Ge G, Ji H. LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling. Proc Natl Acad Sci U S A. 2010 Nov 02; 107(44):18892-7. PMID: 20956321; PMCID: PMC2973865.
    Citations: 97     Fields:    Translation:HumansAnimalsCells
  21. Sun Y, Ren Y, Fang Z, Li C, Fang R, Gao B, Han X, Tian W, Pao W, Chen H, Ji H. Lung adenocarcinoma from East Asian never-smokers is a disease largely defined by targetable oncogenic mutant kinases. J Clin Oncol. 2010 Oct 20; 28(30):4616-20. PMID: 20855837; PMCID: PMC2974342.
    Citations: 158     Fields:    Translation:Humans
  22. Gao B, Sun Y, Zhang J, Ren Y, Fang R, Han X, Shen L, Liu XY, Pao W, Chen H, Ji H. Spectrum of LKB1, EGFR, and KRAS mutations in chinese lung adenocarcinomas. J Thorac Oncol. 2010 Aug; 5(8):1130-5. PMID: 20559149; PMCID: PMC4009449.
    Citations: 42     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.