Harvard Catalyst Profiles

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Arun Sharma, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Toepfer CN, Sharma A, Cicconet M, Garfinkel AC, Mücke M, Neyazi M, Willcox JAL, Agarwal R, Schmid M, Rao J, Ewoldt J, Pourquié O, Chopra A, Chen CS, Seidman JG, Seidman CE. SarcTrack. Circ Res. 2019 Apr 12; 124(8):1172-1183. PMID: 30700234.
    Citations:    Fields:    
  2. Kitani T, Ong SG, Lam CK, Rhee JW, Zhang JZ, Oikonomopoulos A, Ma N, Tian L, Lee J, Telli ML, Witteles RM, Sharma A, Sayed N, Wu JC. Human Induced Pluripotent Stem Cell Model of Trastuzumab-Induced Cardiac Dysfunction in Breast Cancer Patients. Circulation. 2019 03 14. PMID: 30866650.
  3. Sharma A, McKeithan WL, Serrano R, Kitani T, Burridge PW, Del Álamo JC, Mercola M, Wu JC. Use of human induced pluripotent stem cell-derived cardiomyocytes to assess drug cardiotoxicity. Nat Protoc. 2018 12; 13(12):3018-3041. PMID: 30413796.
    Citations:    Fields:    
  4. Churko JM, Garg P, Treutlein B, Venkatasubramanian M, Wu H, Lee J, Wessells QN, Chen SY, Chen WY, Chetal K, Mantalas G, Neff N, Jabart E, Sharma A, Nolan GP, Salomonis N, Wu JC. Defining human cardiac transcription factor hierarchies using integrated single-cell heterogeneity analysis. Nat Commun. 2018 11 21; 9(1):4906. PMID: 30464173.
    Citations:    Fields:    Translation:HumansCells
  5. Sharma A, Zhang Y, Buikema JW, Serpooshan V, Chirikian O, Kosaric N, Churko JM, Dzilic E, Shieh A, Burridge PW, Wu JC, Wu SM. Stage-specific Effects of Bioactive Lipids on Human iPSC Cardiac Differentiation and Cardiomyocyte Proliferation. Sci Rep. 2018 Apr 26; 8(1):6618. PMID: 29700394.
    Citations:    Fields:    
  6. Sharma A, Mücke M, Seidman CE. Human Induced Pluripotent Stem Cell Production and Expansion from Blood using a Non-Integrating Viral Reprogramming Vector. Curr Protoc Mol Biol. 2018 04; 122(1):e58. PMID: 29851250.
    Citations:    Fields:    
  7. Sharma A, Toepfer CN, Ward T, Wasson L, Agarwal R, Conner DA, Hu JH, Seidman CE. CRISPR/Cas9-Mediated Fluorescent Tagging of Endogenous Proteins in Human Pluripotent Stem Cells. Curr Protoc Hum Genet. 2018 01 24; 96:21.11.1-21.11.20. PMID: 29364519.
    Citations: 1     Fields:    
  8. Sharma A, Toepfer CN, Schmid M, Garfinkel AC, Seidman CE. Differentiation and Contractile Analysis of GFP-Sarcomere Reporter hiPSC-Cardiomyocytes. Curr Protoc Hum Genet. 2018 01 24; 96:21.12.1-21.12.12. PMID: 29364522.
    Citations: 1     Fields:    
  9. Serpooshan V, Chen P, Wu H, Lee S, Sharma A, Hu DA, Venkatraman S, Ganesan AV, Usta OB, Yarmush M, Yang F, Wu JC, Demirci U, Wu SM. Bioacoustic-enabled patterning of human iPSC-derived cardiomyocytes into 3D cardiac tissue. Biomaterials. 2017 07; 131:47-57. PMID: 28376365.
    Citations: 1     Fields:    Translation:HumansCells
  10. Chuang W, Sharma A, Shukla P, Li G, Mall M, Rajarajan K, Abilez OJ, Hamaguchi R, Wu JC, Wernig M, Wu SM. Partial Reprogramming of Pluripotent Stem Cell-Derived Cardiomyocytes into Neurons. Sci Rep. 2017 03 22; 7:44840. PMID: 28327614.
    Citations: 1     Fields:    Translation:AnimalsCells
  11. Sharma A, Burridge PW, McKeithan WL, Serrano R, Shukla P, Sayed N, Churko JM, Kitani T, Wu H, Holmström A, Matsa E, Zhang Y, Kumar A, Fan AC, Del Álamo JC, Wu SM, Moslehi JJ, Mercola M, Wu JC. High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells. Sci Transl Med. 2017 02 15; 9(377). PMID: 28202772.
    Citations: 23     Fields:    Translation:HumansCells
  12. Liang P, Sallam K, Wu H, Li Y, Itzhaki I, Garg P, Zhang Y, Vermglinchan V, Lan F, Gu M, Gong T, Zhuge Y, He C, Ebert AD, Sanchez-Freire V, Churko J, Hu S, Sharma A, Lam CK, Scheinman MM, Bers DM, Wu JC. Patient-Specific and Genome-Edited Induced Pluripotent Stem Cell-Derived Cardiomyocytes Elucidate Single-Cell Phenotype of Brugada Syndrome. J Am Coll Cardiol. 2016 11 08; 68(19):2086-2096. PMID: 27810048.
    Citations: 18     Fields:    Translation:HumansCells
  13. Burridge PW, Li YF, Matsa E, Wu H, Ong SG, Sharma A, Holmström A, Chang AC, Coronado MJ, Ebert AD, Knowles JW, Telli ML, Witteles RM, Blau HM, Bernstein D, Altman RB, Wu JC. Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity. Nat Med. 2016 05; 22(5):547-56. PMID: 27089514.
    Citations: 58     Fields:    Translation:HumansCells
  14. Burridge PW, Diecke S, Matsa E, Sharma A, Wu H, Wu JC. Modeling Cardiovascular Diseases with Patient-Specific Human Pluripotent Stem Cell-Derived Cardiomyocytes. Methods Mol Biol. 2016; 1353:119-30. PMID: 25690476.
    Citations: 8     Fields:    Translation:HumansCells
  15. Sharma A, Sebastiano V, Scott CT, Magnus D, Koyano-Nakagawa N, Garry DJ, Witte ON, Nakauchi H, Wu JC, Weissman IL, Wu SM. Lift NIH restrictions on chimera research. Science. 2015 Nov 06; 350(6261):640. PMID: 26542560.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  16. Sharma A, Zhang Y, Wu SM. Harnessing the Induction of Cardiomyocyte Proliferation for Cardiac Regenerative Medicine. Curr Treat Options Cardiovasc Med. 2015 Oct; 17(10):404. PMID: 26324824.
    Citations: 4     
  17. Sharma A, Wu SM. Members Only: Hypoxia-Induced Cell-Cycle Activation in Cardiomyocytes. Cell Metab. 2015 Sep 01; 22(3):365-6. PMID: 26331604.
    Citations: 2     Fields:    Translation:AnimalsCells
  18. Wu H, Lee J, Vincent LG, Wang Q, Gu M, Lan F, Churko JM, Sallam KI, Matsa E, Sharma A, Gold JD, Engler AJ, Xiang YK, Bers DM, Wu JC. Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised ß-Adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy. Cell Stem Cell. 2015 Jul 02; 17(1):89-100. PMID: 26095046.
    Citations: 30     Fields:    Translation:HumansCells
  19. Sharma A, Scott CT. The ethics of publishing human germline research. Nat Biotechnol. 2015 Jun; 33(6):590-2. PMID: 26057973.
    Citations: 3     Fields:    Translation:HumansCells
  20. Sturzu AC, Rajarajan K, Passer D, Plonowska K, Riley A, Tan TC, Sharma A, Xu AF, Engels MC, Feistritzer R, Li G, Selig MK, Geissler R, Robertson KD, Scherrer-Crosbie M, Domian IJ, Wu SM. Fetal Mammalian Heart Generates a Robust Compensatory Response to Cell Loss. Circulation. 2015 Jul 14; 132(2):109-21. PMID: 25995316.
    Citations: 21     Fields:    Translation:AnimalsCells
  21. Sharma A, Li G, Rajarajan K, Hamaguchi R, Burridge PW, Wu SM. Derivation of highly purified cardiomyocytes from human induced pluripotent stem cells using small molecule-modulated differentiation and subsequent glucose starvation. J Vis Exp. 2015 Mar 18; (97). PMID: 25867738.
    Citations: 7     Fields:    Translation:HumansCells
  22. Diecke S, Lu J, Lee J, Termglinchan V, Kooreman NG, Burridge PW, Ebert AD, Churko JM, Sharma A, Kay MA, Wu JC. Novel codon-optimized mini-intronic plasmid for efficient, inexpensive, and xeno-free induction of pluripotency. Sci Rep. 2015 Jan 28; 5:8081. PMID: 25628230.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  23. Burridge PW, Sharma A, Wu JC. Genetic and Epigenetic Regulation of Human Cardiac Reprogramming and Differentiation in Regenerative Medicine. Annu Rev Genet. 2015; 49:461-84. PMID: 26631515.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  24. Sharma A, Marceau C, Hamaguchi R, Burridge PW, Rajarajan K, Churko JM, Wu H, Sallam KI, Matsa E, Sturzu AC, Che Y, Ebert A, Diecke S, Liang P, Red-Horse K, Carette JE, Wu SM, Wu JC. Human induced pluripotent stem cell-derived cardiomyocytes as an in vitro model for coxsackievirus B3-induced myocarditis and antiviral drug screening platform. Circ Res. 2014 Aug 29; 115(6):556-66. PMID: 25015077.
    Citations: 30     Fields:    Translation:HumansCells
  25. Engels MC, Rajarajan K, Feistritzer R, Sharma A, Nielsen UB, Schalij MJ, de Vries AA, Pijnappels DA, Wu SM. Insulin-like growth factor promotes cardiac lineage induction in vitro by selective expansion of early mesoderm. Stem Cells. 2014 Jun; 32(6):1493-502. PMID: 24496962.
    Citations: 9     Fields:    Translation:AnimalsCells
  26. Sharma A, Wu JC, Wu SM. Induced pluripotent stem cell-derived cardiomyocytes for cardiovascular disease modeling and drug screening. Stem Cell Res Ther. 2013 Dec 24; 4(6):150. PMID: 24476344.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  27. Navarrete EG, Liang P, Lan F, Sanchez-Freire V, Simmons C, Gong T, Sharma A, Burridge PW, Patlolla B, Lee AS, Wu H, Beygui RE, Wu SM, Robbins RC, Bers DM, Wu JC. Screening drug-induced arrhythmia [corrected] using human induced pluripotent stem cell-derived cardiomyocytes and low-impedance microelectrode arrays. Circulation. 2013 Sep 10; 128(11 Suppl 1):S3-13. PMID: 24030418.
    Citations: 74     Fields:    Translation:HumansCells
  28. Sharma A, Wu SM. Of fish and men: clonal lineage analysis identifies divergence in myocardial development. Circ Res. 2013 Feb 15; 112(4):583-5. PMID: 23410876.
    Citations:    Fields:    
  29. Sharma A, Wu SM. Autophagy--the friendly fire in endothelial cell regeneration. Focus on "Autophagy in endothelial progenitor cells is cytoprotective in hypoxic conditions". Am J Physiol Cell Physiol. 2013 Apr 01; 304(7):C614-6. PMID: 23407881.
    Citations: 2     Fields:    Translation:HumansCells
  30. Lee NY, Golzio C, Gatza CE, Sharma A, Katsanis N, Blobe GC. Endoglin regulates PI3-kinase/Akt trafficking and signaling to alter endothelial capillary stability during angiogenesis. Mol Biol Cell. 2012 Jul; 23(13):2412-23. PMID: 22593212.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.