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Charlene J Ong, M.D.

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Available: 11/28/18, Expires: 11/28/19

Of the 800,000 Americans yearly who experience a stroke, the 5th leading cause of death in the US, ~185,000 are recurrent attacks.2 While research has been conducted to determine relevant risk factors,2 uncertainty remains regarding: 1) an individual’s relative risk of suffering an additional stroke; and 2) how to select optimal individual prevention strategies. Artificial intelligence methods hold promise for answering these questions. However, insufficient work has been done to harness these methods. To improve personalized risk assessment, we must employ predictive pattern technology and integrate computer assisted analysis of brain/vascular imaging with clinical data. The objective of our project is to use machine learning methods to automate text and image analyses of radiographic data as it relates to stroke patients, and use it to construct personalized risk predictions and medical management recommendations. For this project, we hope to recruit eager students who wish to immerse themselves in neuroanatomy and radiology by assisting in the labeling of radiographic text to train an algorithm. We work with an interdisciplinary and multi-institutional team of data scientists, physicians and statisticians at Harvard Medical School, Massachusetts Institute of Technology and Boston University.


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  1. Ong CJ, Gluckstein J, Laurido-Soto O, Yan Y, Dhar R, Lee JM. Enhanced Detection of Edema in Malignant Anterior Circulation Stroke (EDEMA) Score: A Risk Prediction Tool. Stroke. 2017 07; 48(7):1969-1972. PMID: 28487333.
    Citations: 1     Fields:    Translation:Humans
  2. Ong CJ, Dhand A, Diringer MN. Early Withdrawal Decision-Making in Patients with Coma After Cardiac Arrest: A Qualitative Study of Intensive Care Clinicians. Neurocrit Care. 2016 10; 25(2):258-65. PMID: 27112149.
    Citations: 3     Fields:    Translation:Humans
  3. Ong CJ, Yarbrough CK, Derdeyn CP. Response to Letter Regarding Article, "Endovascular Thrombectomy for Anterior Circulation Stroke: Systematic Review and Meta-Analysis". Stroke. 2015 Dec; 46(12):e259. PMID: 26534973.
    Citations:    Fields:    Translation:Humans
  4. Yarbrough CK, Ong CJ, Beyer AB, Lipsey K, Derdeyn CP. Endovascular Thrombectomy for Anterior Circulation Stroke: Systematic Review and Meta-Analysis. Stroke. 2015 Nov; 46(11):3177-83. PMID: 26396032.
    Citations: 6     Fields:    Translation:Humans
  5. Ong CJ, Al-Lozi M, Cimino PJ, Bucelli R. Peripheral nervous system hyperexcitability in VV2 sporadic Creutzfeldt-Jakob disease. Neurol Clin Pract. 2015 Aug; 5(4):326-332. PMID: 29443232.
    Citations:    
  6. Ong CJ. Tipping point: Head computed tomography and its impact on neurology training. Ann Neurol. 2015 Apr; 77(4):556-9. PMID: 25612080.
    Citations:    Fields:    Translation:Humans
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.