Harvard Catalyst Profiles

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Joseph O'Flynn, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. O'Flynn J, Kotimaa J, Faber-Krol R, Koekkoek K, Klar-Mohamad N, Koudijs A, Schwaeble WJ, Stover C, Daha MR, van Kooten C. Properdin binds independent of complement activation in an in vivo model of anti-glomerular basement membrane disease. Kidney Int. 2018 12; 94(6):1141-1150. PMID: 30322716.
    Citations:    Fields:    
  2. Dixon KO, O'Flynn J, Klar-Mohamad N, Daha MR, van Kooten C. Properdin and factor H production by human dendritic cells modulates their T-cell stimulatory capacity and is regulated by IFN-?. Eur J Immunol. 2017 03; 47(3):470-480. PMID: 28105653.
    Citations: 3     Fields:    Translation:HumansCells
  3. Das A, Heesters BA, Bialas A, O'Flynn J, Rifkin IR, Ochando J, Mittereder N, Carlesso G, Herbst R, Carroll MC. Follicular Dendritic Cell Activation by TLR Ligands Promotes Autoreactive B Cell Responses. Immunity. 2017 01 17; 46(1):106-119. PMID: 28099860.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  4. O'Flynn J, van der Pol P, Dixon KO, Proh√°szka Z, Daha MR, van Kooten C. Monomeric C-reactive protein inhibits renal cell-directed complement activation mediated by properdin. Am J Physiol Renal Physiol. 2016 06 01; 310(11):F1308-16. PMID: 26984957.
    Citations: 3     Fields:    Translation:HumansCells
  5. Kotimaa JP, van Werkhoven MB, O'Flynn J, Klar-Mohamad N, van Groningen J, Schilders G, Rutjes H, Daha MR, Seelen MA, van Kooten C. Functional assessment of mouse complement pathway activities and quantification of C3b/C3c/iC3b in an experimental model of mouse renal ischaemia/reperfusion injury. J Immunol Methods. 2015 Apr; 419:25-34. PMID: 25733354.
    Citations: 4     Fields:    Translation:Animals
  6. Klop B, van der Pol P, van Bruggen R, Wang Y, de Vries MA, van Santen S, O'Flynn J, van de Geijn GJ, Njo TL, Janssen HW, de Man P, Jukema JW, Rabelink TJ, Rensen PC, van Kooten C, Cabezas MC. Differential complement activation pathways promote C3b deposition on native and acetylated LDL thereby inducing lipoprotein binding to the complement receptor 1. J Biol Chem. 2014 Dec 19; 289(51):35421-30. PMID: 25349208.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  7. Dixon KO, O'Flynn J, van der Kooij SW, van Kooten C. Phagocytosis of apoptotic or necrotic cells differentially regulates the transcriptional expression of IL-12 family members in dendritic cells. J Leukoc Biol. 2014 Aug; 96(2):313-24. PMID: 24782489.
    Citations: 7     Fields:    Translation:HumansCells
  8. O'Flynn J, Krol MC, Daha MR, van Kooten C. Purification and functional analysis of human properdin. Methods Mol Biol. 2014; 1100:161-7. PMID: 24218258.
    Citations: 1     Fields:    Translation:HumansCells
  9. O'Flynn J, Dixon KO, Faber Krol MC, Daha MR, van Kooten C. Myeloperoxidase directs properdin-mediated complement activation. J Innate Immun. 2014; 6(4):417-25. PMID: 24355864.
    Citations: 7     Fields:    Translation:HumansCells
  10. O'Flynn J, Flierman R, van der Pol P, Rops A, Satchell SC, Mathieson PW, van Kooten C, van der Vlag J, Berden JH, Daha MR. Nucleosomes and C1q bound to glomerular endothelial cells serve as targets for autoantibodies and determine complement activation. Mol Immunol. 2011 Oct; 49(1-2):75-83. PMID: 21855148.
    Citations: 6     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.