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Amir Sharabi, Ph.D., M.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Meidan E, Li H, Pan W, Kono M, Yu S, Kyttaris VC, Ioannidis C, Rodriguez Rodriguez N, Crispin JC, Apostolidis SA, Lee P, Manis J, Sharabi A, Tsokos MG, Tsokos GC. Serine/threonine phosphatase PP2A is essential for optimal B cell function. JCI Insight. 2020 Mar 12; 5(5). PMID: 32161189.
  2. Sharabi A, Tsokos GC. T cell metabolism: new insights in systemic lupus erythematosus pathogenesis and therapy. Nat Rev Rheumatol. 2020 Feb; 16(2):100-112. PMID: 31949287.
  3. Sharabi A, Li H, Kasper IR, Pan W, Meidan E, Tsokos MG, Moulton VR, Tsokos GC. PP2A enables IL-2 signaling by preserving IL-2Rß chain expression during Treg development. JCI Insight. 2019 Mar 26; 5. PMID: 30912768.
  4. Sharabi A, Tsokos MG, Ding Y, Malek TR, Klatzmann D, Tsokos GC. Regulatory T cells in the treatment of disease. Nat Rev Drug Discov. 2018 11; 17(11):823-844. PMID: 30310234.
    Citations:    Fields:    
  5. Sthoeger Z, Sharabi A, Zinger H, Asher I, Mozes E. Indoleamine-2,3-dioxygenase in murine and human systemic lupus erythematosus: Down-regulation by the tolerogeneic peptide hCDR1. Clin Immunol. 2018 12; 197:34-39. PMID: 30170030.
    Citations:    Fields:    
  6. Li H, Tsokos MG, Bickerton S, Sharabi A, Li Y, Moulton VR, Kong P, Fahmy TM, Tsokos GC. Precision DNA demethylation ameliorates disease in lupus-prone mice. JCI Insight. 2018 08 23; 3(16). PMID: 30135300.
    Citations:    Fields:    
  7. Gibor G, Ilan N, Journo S, Sharabi A, Dreyer J, Gertel S, Singh P, Menachem A, Snir N, Elkayam O, Vlodavsky I, Arad U. Heparanase is expressed in adult human osteoarthritic cartilage and drives catabolic responses in primary chondrocytes. Osteoarthritis Cartilage. 2018 08; 26(8):1110-1117. PMID: 29803826.
    Citations:    Fields:    
  8. Sthoeger Z, Sharabi A, Asher I, Zinger H, Segal R, Shearer G, Elkayam O, Mozes E. The tolerogenic peptide hCDR1 immunomodulates cytokine and regulatory molecule gene expression in blood mononuclear cells of primary Sjogren's syndrome patients. Clin Immunol. 2018 07; 192:85-91. PMID: 29730433.
    Citations:    Fields:    
  9. Sharabi A, Kasper IR, Tsokos GC. The serine/threonine protein phosphatase 2A controls autoimmunity. Clin Immunol. 2018 01; 186:38-42. PMID: 28736280.
    Citations: 1     Fields:    Translation:HumansAnimals
  10. Anis S, Sharabi A, Mina Y, Klein A, Cagnano E, Elkayam O, Gurevich T. Rituximab as a Second-Line Treatment for Lymphocytic Vasculitis of the Central Nervous System. Isr Med Assoc J. 2016 Oct; 18(10):630-632. PMID: 28471627.
    Citations:    Fields:    Translation:Humans
  11. Kasper IR, Apostolidis SA, Sharabi A, Tsokos GC. Empowering Regulatory T Cells in Autoimmunity. Trends Mol Med. 2016 09; 22(9):784-797. PMID: 27461103.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  12. Litinsky I, Fireman E, Paran D, Polachek A, Broide A, Sharabi A, Anouk M, Elkayam O. Induced Sputum Analysis in Subjects With Systemic Sclerosis. Respir Care. 2016 Oct; 61(10):1369-73. PMID: 27274093.
    Citations:    Fields:    Translation:HumansCells
  13. Brikman S, Furer V, Wollman J, Borok S, Matz H, Polachek A, Elalouf O, Sharabi A, Kaufman I, Paran D, Elkayam O. The Effect of the Presence of Fibromyalgia on Common Clinical Disease Activity Indices in Patients with Psoriatic Arthritis: A Cross-sectional Study. J Rheumatol. 2016 09; 43(9):1749-54. PMID: 27252430.
    Citations: 5     Fields:    Translation:Humans
  14. Sharabi A. Editorial: Molecules Balancing Immunological Surveillance against Cancer and Autoimmune Diseases. Front Oncol. 2016; 6:86. PMID: 27148478.
  15. Sthoeger Z, Sharabi A, Mozes E. Novel approaches to the development of targeted therapeutic agents for systemic lupus erythematosus. J Autoimmun. 2014 Nov; 54:60-71. PMID: 24958634.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  16. Sthoeger Z, Zinger H, Sharabi A, Asher I, Mozes E. The tolerogenic peptide, hCDR1, down-regulates the expression of interferon-a in murine and human systemic lupus erythematosus. PLoS One. 2013; 8(3):e60394. PMID: 23555966.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  17. Sharabi A, Haran-Ghera N. Immune recovery after cyclophosphamide treatment in multiple myeloma: implication for maintenance immunotherapy. Bone Marrow Res. 2011; 2011:269519. PMID: 22046558.
    Citations: 3     
  18. Telerman A, Lapter S, Sharabi A, Zinger H, Mozes E. Induction of hippocampal neurogenesis by a tolerogenic peptide that ameliorates lupus manifestations. J Neuroimmunol. 2011 Mar; 232(1-2):151-7. PMID: 21129786.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  19. Lapter S, Ben-David H, Sharabi A, Zinger H, Telerman A, Gordin M, Leng L, Bucala R, Shachar I, Mozes E. A role for the B-cell CD74/macrophage migration inhibitory factor pathway in the immunomodulation of systemic lupus erythematosus by a therapeutic tolerogenic peptide. Immunology. 2011 Jan; 132(1):87-95. PMID: 20738420.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  20. Sharabi A, Laronne-Bar-On A, Meshorer A, Haran-Ghera N. Chemoimmunotherapy reduces the progression of multiple myeloma in a mouse model. Cancer Prev Res (Phila). 2010 Oct; 3(10):1265-76. PMID: 20719903.
    Citations: 9     Fields:    Translation:AnimalsCells
  21. Mozes E, Sharabi A. A novel tolerogenic peptide, hCDR1, for the specific treatment of systemic lupus erythematosus. Autoimmun Rev. 2010 Nov; 10(1):22-6. PMID: 20659591.
    Citations: 8     Fields:    Translation:HumansAnimals
  22. Sharabi A, Mozes E. Bcl-xL affects the development of functional CD4 Tregs. Arthritis Res Ther. 2010; 12(4):405. PMID: 20687901.
    Citations: 1     Fields:    Translation:AnimalsCells
  23. Sharabi A, Ghera NH. Breaking tolerance in a mouse model of multiple myeloma by chemoimmunotherapy. Adv Cancer Res. 2010; 107:1-37. PMID: 20399959.
    Citations: 6     Fields:    Translation:AnimalsCells
  24. Arazi A, Sharabi A, Zinger H, Mozes E, Neumann AU. In vivo dynamical interactions between CD4 Tregs, CD8 Tregs and CD4+ CD25- cells in mice. PLoS One. 2009 Dec 24; 4(12):e8447. PMID: 20041142.
    Citations: 9     Fields:    Translation:AnimalsCells
  25. Lapter S, Marom A, Meshorer A, Elmann A, Sharabi A, Vadai E, Neufeld A, Sztainberg Y, Gil S, Getselter D, Chen A, Mozes E. Amelioration of brain pathology and behavioral dysfunction in mice with lupus following treatment with a tolerogenic peptide. Arthritis Rheum. 2009 Dec; 60(12):3744-54. PMID: 19950283.
    Citations: 6     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  26. Ben-David H, Sharabi A, Parameswaran R, Zinger H, Mozes E. A tolerogenic peptide down-regulates mature B cells in bone marrow of lupus-afflicted mice by inhibition of interleukin-7, leading to apoptosis. Immunology. 2009 Oct; 128(2):245-52. PMID: 19740381.
    Citations: 3     Fields:    Translation:AnimalsCells
  27. Sharabi A, Dayan M, Zinger H, Mozes E. A new model of induced experimental systemic lupus erythematosus (SLE) in pigs and its amelioration by treatment with a tolerogenic peptide. J Clin Immunol. 2010 Jan; 30(1):34-44. PMID: 19756988.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  28. Sharabi A, Sthoeger ZM, Mahlab K, Lapter S, Zinger H, Mozes E. A tolerogenic peptide that induces suppressor of cytokine signaling (SOCS)-1 restores the aberrant control of IFN-gamma signaling in lupus-affected (NZB x NZW)F1 mice. Clin Immunol. 2009 Oct; 133(1):61-8. PMID: 19631585.
    Citations: 7     Fields:    Translation:AnimalsCells
  29. Sharabi A, Lapter S, Mozes E. Bcl-xL is required for the development of functional regulatory CD4 cells in lupus-afflicted mice following treatment with a tolerogenic peptide. J Autoimmun. 2010 Mar; 34(2):87-95. PMID: 19596183.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  30. Sharabi A, Mozes E. Harnessing regulatory T cells for the therapy of lupus and other autoimmune diseases. Immunotherapy. 2009 May; 1(3):385-401. PMID: 20635958.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  31. Sthoeger ZM, Sharabi A, Molad Y, Asher I, Zinger H, Dayan M, Mozes E. Treatment of lupus patients with a tolerogenic peptide, hCDR1 (Edratide): immunomodulation of gene expression. J Autoimmun. 2009 Aug; 33(1):77-82. PMID: 19346102.
    Citations: 15     Fields:    Translation:HumansCells
  32. Sthoeger ZM, Sharabi A, Dayan M, Zinger H, Asher I, Sela U, Mozes E. The tolerogenic peptide hCDR1 downregulates pathogenic cytokines and apoptosis and upregulates immunosuppressive molecules and regulatory T cells in peripheral blood mononuclear cells of lupus patients. Hum Immunol. 2009 Mar; 70(3):139-45. PMID: 19280712.
    Citations: 4     Fields:    Translation:HumansCells
  33. Parameswaran R, Ben David H, Sharabi A, Zinger H, Mozes E. B-cell activating factor (BAFF) plays a role in the mechanism of action of a tolerogenic peptide that ameliorates lupus. Clin Immunol. 2009 May; 131(2):223-32. PMID: 19188092.
    Citations: 6     Fields:    Translation:AnimalsCells
  34. Sela U, Sharabi A, Dayan M, Hershkoviz R, Mozes E. The role of dendritic cells in the mechanism of action of a peptide that ameliorates lupus in murine models. Immunology. 2009 Sep; 128(1 Suppl):e395-405. PMID: 19040426.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  35. Sharabi A, Mozes E. The suppression of murine lupus by a tolerogenic peptide involves foxp3-expressing CD8 cells that are required for the optimal induction and function of foxp3-expressing CD4 cells. J Immunol. 2008 Sep 01; 181(5):3243-51. PMID: 18713995.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  36. Mozes E, Sela U, Sharabi A. A novel synthetic peptide for the specific treatment of lupus: clinical effects and mechanism of action. Isr Med Assoc J. 2008 Jan; 10(1):40-2. PMID: 18300570.
    Citations: 2     Fields:    Translation:AnimalsCells
  37. Ben-David H, Sharabi A, Dayan M, Sela M, Mozes E. The role of CD8+CD28 regulatory cells in suppressing myasthenia gravis-associated responses by a dual altered peptide ligand. Proc Natl Acad Sci U S A. 2007 Oct 30; 104(44):17459-64. PMID: 17956982.
    Citations: 13     Fields:    Translation:AnimalsCellsPHPublic Health
  38. Sharabi A, Luger D, Ben-David H, Dayan M, Zinger H, Mozes E. The role of apoptosis in the ameliorating effects of a CDR1-based peptide on lupus manifestations in a mouse model. J Immunol. 2007 Oct 15; 179(8):4979-87. PMID: 17911582.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  39. Elmann A, Sharabi A, Dayan M, Zinger H, Ophir R, Mozes E. Altered gene expression in mice with lupus treated with edratide, a peptide that ameliorates the disease manifestations. Arthritis Rheum. 2007 Jul; 56(7):2371-81. PMID: 17599765.
    Citations: 2     Fields:    Translation:AnimalsCells
  40. Sharabi A, Azulai H, Sthoeger ZM, Mozes E. Clinical amelioration of murine lupus by a peptide based on the complementarity determining region-1 of an autoantibody and by cyclophosphamide: similarities and differences in the mechanisms of action. Immunology. 2007 Jun; 121(2):248-57. PMID: 17346282.
    Citations: 7     Fields:    Translation:AnimalsCells
  41. Sharabi A, Zinger H, Zborowsky M, Sthoeger ZM, Mozes E. A peptide based on the complementarity-determining region 1 of an autoantibody ameliorates lupus by up-regulating CD4+CD25+ cells and TGF-beta. Proc Natl Acad Sci U S A. 2006 Jun 06; 103(23):8810-5. PMID: 16735466.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  42. Sharabi A, Haviv A, Zinger H, Dayan M, Mozes E. Amelioration of murine lupus by a peptide, based on the complementarity determining region-1 of an autoantibody as compared to dexamethasone: different effects on cytokines and apoptosis. Clin Immunol. 2006 May; 119(2):146-55. PMID: 16503419.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  43. Rapoport MJ, Sharabi A, Aharoni D, Bloch O, Zinger H, Dayan M, Mozes E. Amelioration of SLE-like manifestations in (NZBxNZW)F1 mice following treatment with a peptide based on the complementarity determining region 1 of an autoantibody is associated with a down-regulation of apoptosis and of the pro-apoptotic factor JNK kinase. Clin Immunol. 2005 Dec; 117(3):262-70. PMID: 16257268.
    Citations: 6     Fields:    Translation:AnimalsCellsPHPublic Health
  44. Sharabi A, Cohen E, Sulkes J, Garty M. Replacement therapy for vitamin B12 deficiency: comparison between the sublingual and oral route. Br J Clin Pharmacol. 2003 Dec; 56(6):635-8. PMID: 14616423.
    Citations: 8     Fields:    Translation:HumansCTClinical Trials
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.