Harvard Catalyst Profiles

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Stephanie Grabow, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ke F, Lancaster GI, Grabow S, Murphy AJ, Strasser A. Combined reduction in the expression of MCL-1 and BCL-2 reduces organismal size in mice. Cell Death Dis. 2020 Mar 13; 11(3):185. PMID: 32170090.
  2. Kamoun WS, Dugast AS, Suchy JJ, Grabow S, Fulton RB, Sampson JF, Luus L, Santiago M, Koshkaryev A, Sun G, Askoxylakis V, Tam E, Huang ZR, Drummond DC, Sawyer AJ. Synergy between EphA2-ILs-DTXp, a Novel EphA2-Targeted Nanoliposomal Taxane, and PD-1 Inhibitors in Preclinical Tumor Models. Mol Cancer Ther. 2020 01; 19(1):270-281. PMID: 31597714.
  3. Tam EM, Fulton RB, Sampson JF, Muda M, Camblin A, Richards J, Koshkaryev A, Tang J, Kurella V, Jiao Y, Xu L, Zhang K, Kohli N, Luus L, Hutto E, Kumar S, Lulo J, Paragas V, Wong C, Suchy J, Grabow S, Dugast AS, Zhang H, Depis F, Feau S, Jakubowski A, Qiao W, Craig G, Razlog M, Qiu J, Zhou Y, Marks JD, Croft M, Drummond DC, Raue A. Antibody-mediated targeting of TNFR2 activates CD8+ T cells in mice and promotes antitumor immunity. Sci Transl Med. 2019 10 02; 11(512). PMID: 31578241.
  4. Kamoun WS, Kirpotin DB, Huang ZR, Tipparaju SK, Noble CO, Hayes ME, Luus L, Koshkaryev A, Kim J, Olivier K, Kornaga T, Oyama S, Askoxylakis V, Pien C, Kuesters G, Dumont N, Lugovskoy AA, Schihl SA, Wilton JH, Geddie ML, Suchy J, Grabow S, Kohli N, Reynolds CP, Blaydes R, Zhou Y, Sawyer AJ, Marks JD, Drummond DC. Antitumour activity and tolerability of an EphA2-targeted nanotherapeutic in multiple mouse models. Nat Biomed Eng. 2019 04; 3(4):264-280. PMID: 30952988.
  5. Grabow S, Kueh AJ, Ke F, Vanyai HK, Sheikh BN, Dengler MA, Chiang W, Eccles S, Smyth IM, Jones LK, de Sauvage FJ, Scott M, Whitehead L, Voss AK, Strasser A. Subtle Changes in the Levels of BCL-2 Proteins Cause Severe Craniofacial Abnormalities. Cell Rep. 2018 09 18; 24(12):3285-3295.e4. PMID: 30232009.
    Citations:    Fields:    
  6. Yasmin-Karim S, Bruck PT, Moreau M, Kunjachan S, Chen GZ, Kumar R, Grabow S, Dougan SK, Ngwa W. Radiation and Local Anti-CD40 Generate an Effective in situ Vaccine in Preclinical Models of Pancreatic Cancer. Front Immunol. 2018; 9:2030. PMID: 30245691.
  7. Valentin R, Grabow S, Davids MS. The rise of apoptosis: targeting apoptosis in hematologic malignancies. Blood. 2018 09 20; 132(12):1248-1264. PMID: 30012635.
    Citations:    Fields:    
  8. Ke FFS, Vanyai HK, Cowan AD, Delbridge ARD, Whitehead L, Grabow S, Czabotar PE, Voss AK, Strasser A. Embryogenesis and Adult Life in the Absence of Intrinsic Apoptosis Effectors BAX, BAK, and BOK. Cell. 2018 05 17; 173(5):1217-1230.e17. PMID: 29775594.
    Citations: 2     Fields:    
  9. Delbridge AR, Grabow S, Strasser A. Loss of BIM augments resistance of ATM-deficient thymocytes to DNA damage-induced apoptosis but does not accelerate lymphoma development. Cell Death Differ. 2017 11; 24(11):1987-1988. PMID: 28885618.
    Citations:    Fields:    
  10. Brinkmann K, Grabow S, Hyland CD, Teh CE, Alexander WS, Herold MJ, Strasser A. The combination of reduced MCL-1 and standard chemotherapeutics is tolerable in mice. Cell Death Differ. 2017 12; 24(12):2032-2043. PMID: 28800129.
    Citations: 2     Fields:    Translation:AnimalsCells
  11. Delbridge AR, Aubrey BJ, Hyland C, Bernardini JP, Di Rago L, Garnier JM, Lessene G, Strasser A, Alexander WS, Grabow S. The BH3-only proteins BIM and PUMA are not critical for the reticulocyte apoptosis caused by loss of the pro-survival protein BCL-XL. Cell Death Dis. 2017 07 06; 8(7):e2914. PMID: 28682312.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  12. Viant C, Guia S, Hennessy RJ, Rautela J, Pham K, Bernat C, Goh W, Jiao Y, Delconte R, Roger M, Simon V, Souza-Fonseca-Guimaraes F, Grabow S, Belz GT, Kile BT, Strasser A, Gray D, Hodgkin PD, Beutler B, Vivier E, Ugolini S, Huntington ND. Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival. J Exp Med. 2017 02; 214(2):491-510. PMID: 28057804.
    Citations: 5     Fields:    Translation:AnimalsCells
  13. Delbridge AR, Pang SH, Vandenberg CJ, Grabow S, Aubrey BJ, Tai L, Herold MJ, Strasser A. RAG-induced DNA lesions activate proapoptotic BIM to suppress lymphomagenesis in p53-deficient mice. J Exp Med. 2016 09 19; 213(10):2039-48. PMID: 27621418.
    Citations: 4     Fields:    Translation:AnimalsCells
  14. Delbridge AR, Chappaz S, Ritchie ME, Kile BT, Strasser A, Grabow S. Loss of PUMA (BBC3) does not prevent thrombocytopenia caused by the loss of BCL-XL (BCL2L1). Br J Haematol. 2016 09; 174(6):962-9. PMID: 27221652.
    Citations: 1     Fields:    Translation:AnimalsCells
  15. Lee EF, Grabow S, Chappaz S, Dewson G, Hockings C, Kluck RM, Debrincat MA, Gray DH, Witkowski MT, Evangelista M, Pettikiriarachchi A, Bouillet P, Lane RM, Czabotar PE, Colman PM, Smith BJ, Kile BT, Fairlie WD. Physiological restraint of Bak by Bcl-xL is essential for cell survival. Genes Dev. 2016 05 15; 30(10):1240-50. PMID: 27198225.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  16. Grabow S, Kelly GL, Delbridge AR, Kelly PN, Bouillet P, Adams JM, Strasser A. Critical B-lymphoid cell intrinsic role of endogenous MCL-1 in c-MYC-induced lymphomagenesis. Cell Death Dis. 2016 Mar 10; 7:e2132. PMID: 26962682.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  17. Grabow S, Delbridge AR, Aubrey BJ, Vandenberg CJ, Strasser A. Loss of a Single Mcl-1 Allele Inhibits MYC-Driven Lymphomagenesis by Sensitizing Pro-B Cells to Apoptosis. Cell Rep. 2016 Mar 15; 14(10):2337-47. PMID: 26947081.
    Citations: 8     Fields:    Translation:AnimalsCells
  18. Delbridge AR, Grabow S, Strasser A, Vaux DL. Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies. Nat Rev Cancer. 2016 Feb; 16(2):99-109. PMID: 26822577.
    Citations: 71     Fields:    Translation:HumansAnimals
  19. Valente LJ, Grabow S, Vandenberg CJ, Strasser A, Janic A. Combined loss of PUMA and p21 accelerates c-MYC-driven lymphoma development considerably less than loss of one allele of p53. Oncogene. 2016 07 21; 35(29):3866-71. PMID: 26640149.
    Citations: 5     Fields:    Translation:AnimalsCells
  20. Ke F, Grabow S, Kelly GL, Lin A, O'Reilly LA, Strasser A. Impact of the combined loss of BOK, BAX and BAK on the hematopoietic system is slightly more severe than compound loss of BAX and BAK. Cell Death Dis. 2015 Oct 22; 6:e1938. PMID: 26492371.
    Citations: 7     Fields:    Translation:AnimalsCells
  21. Delbridge AR, Opferman JT, Grabow S, Strasser A. Antagonism between MCL-1 and PUMA governs stem/progenitor cell survival during hematopoietic recovery from stress. Blood. 2015 May 21; 125(21):3273-80. PMID: 25847014.
    Citations: 12     Fields:    Translation:AnimalsCells
  22. Carrington EM, Zhang JG, Sutherland RM, Vikstrom IB, Brady JL, Soo P, Vremec D, Allison C, Lee EF, Fairlie WD, Bouillet P, Grabow S, Ottina E, Herold MJ, Pellegrini M, Huang DC, Tarlinton DM, Strasser A, Lew AM, Zhan Y. Prosurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cells. Proc Natl Acad Sci U S A. 2015 Mar 31; 112(13):4044-9. PMID: 25775525.
    Citations: 10     Fields:    Translation:AnimalsCells
  23. Sheikh BN, Lee SC, El-Saafin F, Vanyai HK, Hu Y, Pang SH, Grabow S, Strasser A, Nutt SL, Alexander WS, Smyth GK, Voss AK, Thomas T. MOZ regulates B-cell progenitors and, consequently, Moz haploinsufficiency dramatically retards MYC-induced lymphoma development. Blood. 2015 Mar 19; 125(12):1910-21. PMID: 25605372.
    Citations: 6     Fields:    Translation:AnimalsCells
  24. Grabow S, Delbridge AR, Valente LJ, Strasser A. MCL-1 but not BCL-XL is critical for the development and sustained expansion of thymic lymphoma in p53-deficient mice. Blood. 2014 Dec 18; 124(26):3939-46. PMID: 25368374.
    Citations: 15     Fields:    Translation:AnimalsCells
  25. Delbridge AR, Grabow S, Bouillet P, Adams JM, Strasser A. Functional antagonism between pro-apoptotic BIM and anti-apoptotic BCL-XL in MYC-induced lymphomagenesis. Oncogene. 2015 Apr 02; 34(14):1872-6. PMID: 24858047.
    Citations: 6     Fields:    Translation:Animals
  26. Kelly GL, Grabow S, Glaser SP, Fitzsimmons L, Aubrey BJ, Okamoto T, Valente LJ, Robati M, Tai L, Fairlie WD, Lee EF, Lindstrom MS, Wiman KG, Huang DC, Bouillet P, Rowe M, Rickinson AB, Herold MJ, Strasser A. Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53. Genes Dev. 2014 Jan 01; 28(1):58-70. PMID: 24395247.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  27. Kelly PN, Grabow S, Delbridge AR, Adams JM, Strasser A. Prophylactic treatment with the BH3 mimetic ABT-737 impedes Myc-driven lymphomagenesis in mice. Cell Death Differ. 2013 Jan; 20(1):57-63. PMID: 22814621.
    Citations: 6     Fields:    Translation:Animals
  28. Grabow S, Waring P, Happo L, Cook M, Mason KD, Kelly PN, Strasser A. Pharmacological blockade of Bcl-2, Bcl-x(L) and Bcl-w by the BH3 mimetic ABT-737 has only minor impact on tumour development in p53-deficient mice. Cell Death Differ. 2012 Apr; 19(4):623-32. PMID: 21997189.
    Citations: 7     Fields:    Translation:HumansAnimals
  29. Kelly PN, Grabow S, Delbridge AR, Strasser A, Adams JM. Endogenous Bcl-xL is essential for Myc-driven lymphomagenesis in mice. Blood. 2011 Dec 08; 118(24):6380-6. PMID: 21998213.
    Citations: 21     Fields:    Translation:AnimalsCells
  30. O' Reilly LA, Tai L, Lee L, Kruse EA, Grabow S, Fairlie WD, Haynes NM, Tarlinton DM, Zhang JG, Belz GT, Smyth MJ, Bouillet P, Robb L, Strasser A. Membrane-bound Fas ligand only is essential for Fas-induced apoptosis. Nature. 2009 Oct 01; 461(7264):659-63. PMID: 19794494.
    Citations: 111     Fields:    Translation:AnimalsCells
  31. Jost PJ, Grabow S, Gray D, McKenzie MD, Nachbur U, Huang DC, Bouillet P, Thomas HE, Borner C, Silke J, Strasser A, Kaufmann T. XIAP discriminates between type I and type II FAS-induced apoptosis. Nature. 2009 Aug 20; 460(7258):1035-9. PMID: 19626005.
    Citations: 121     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.