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Karen Adelman, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01GM134539 (ADELMAN, KAREN L) Aug 15, 2019 - Jul 31, 2023
    NIH/NIGMS
    Probing the specificity and activity of the metazoan Integrator complex
    Role: Principal Investigator
  2. F32GM066661 (ADELMAN, KAREN L) Aug 1, 2002 - Jul 31, 2005
    NIH/NIGMS
    Single molecule analyses of RNA polymerase II elongation
    Role: Principal Investigator
  3. Z01ES101987 (ADELMAN, KAREN L)
    NIH/NIEHS
    Investigating Transcriptional Responses to the Environment
    Role: Principal Investigator
  4. ZIAES101987 (ADELMAN, KAREN L)
    NIH/NIEHS
    Investigating Transcriptional Responses to the Environment
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Rogers JM, Guo B, Egan ED, Aster JC, Adelman K, Blacklow SC. MAML1-Dependent Notch-Responsive Genes Exhibit Differing Cofactor Requirements for Transcriptional Activation. Mol Cell Biol. 2020 05 14; 40(11). PMID: 32179552.
    Citations:    
  2. Santoriello C, Sporrij A, Yang S, Flynn RA, Henriques T, Dorjsuren B, Custo Greig E, McCall W, Stanhope ME, Fazio M, Superdock M, Lichtig A, Adatto I, Abraham BJ, Kalocsay M, Jurynec M, Zhou Y, Adelman K, Calo E, Zon LI. RNA helicase DDX21 mediates nucleotide stress responses in neural crest and melanoma cells. Nat Cell Biol. 2020 04; 22(4):372-379. PMID: 32231306.
    Citations:    
  3. Field A, Adelman K. Evaluating Enhancer Function and Transcription. Annu Rev Biochem. 2020 06 20; 89:213-234. PMID: 32197056.
    Citations:    
  4. Elrod ND, Henriques T, Huang KL, Tatomer DC, Wilusz JE, Wagner EJ, Adelman K. The Integrator Complex Attenuates Promoter-Proximal Transcription at Protein-Coding Genes. Mol Cell. 2019 12 05; 76(5):738-752.e7. PMID: 31809743.
    Citations:    
  5. Etchegaray JP, Zhong L, Li C, Henriques T, Ablondi E, Nakadai T, Van Rechem C, Ferrer C, Ross KN, Choi JE, Samarakkody A, Ji F, Chang A, Sadreyev RI, Ramaswamy S, Nechaev S, Whetstine JR, Roeder RG, Adelman K, Goren A, Mostoslavsky R. The Histone Deacetylase SIRT6 Restrains Transcription Elongation via Promoter-Proximal Pausing. Mol Cell. 2019 08 22; 75(4):683-699.e7. PMID: 31399344.
    Citations:    
  6. Oldfield AJ, Henriques T, Kumar D, Burkholder AB, Cinghu S, Paulet D, Bennett BD, Yang P, Scruggs BS, Lavender CA, Rivals E, Adelman K, Jothi R. NF-Y controls fidelity of transcription initiation at gene promoters through maintenance of the nucleosome-depleted region. Nat Commun. 2019 07 11; 10(1):3072. PMID: 31296853.
    Citations:    
  7. Sendinc E, Valle-Garcia D, Dhall A, Chen H, Henriques T, Navarrete-Perea J, Sheng W, Gygi SP, Adelman K, Shi Y. PCIF1 Catalyzes m6Am mRNA Methylation to Regulate Gene Expression. Mol Cell. 2019 08 08; 75(3):620-630.e9. PMID: 31279659.
    Citations:    
  8. Core L, Adelman K. Promoter-proximal pausing of RNA polymerase II: a nexus of gene regulation. Genes Dev. 2019 08 01; 33(15-16):960-982. PMID: 31123063.
    Citations:    
  9. Hewitt SC, Li R, Adams N, Winuthayanon W, Hamilton KJ, Donoghue LJ, Lierz SL, Garcia M, Lydon JP, DeMayo FJ, Adelman K, Korach KS. Negative elongation factor is essential for endometrial function. FASEB J. 2019 02; 33(2):3010-3023. PMID: 30332301.
    Citations:    Fields:    
  10. Pai AA, Paggi JM, Yan P, Adelman K, Burge CB. Numerous recursive sites contribute to accuracy of splicing in long introns in flies. PLoS Genet. 2018 08; 14(8):e1007588. PMID: 30148878.
    Citations:    Fields:    Translation:AnimalsCells
  11. Adelman K, Henriques T. Transcriptional speed bumps revealed in high resolution. Nature. 2018 08; 560(7720):560-561. PMID: 30143755.
    Citations:    Fields:    
  12. Kaikkonen MU, Adelman K. Emerging Roles of Non-Coding RNA Transcription. Trends Biochem Sci. 2018 09; 43(9):654-667. PMID: 30145998.
    Citations:    Fields:    Translation:HumansAnimalsCells
  13. Meers MP, Adelman K, Duronio RJ, Strahl BD, McKay DJ, Matera AG. Transcription start site profiling uncovers divergent transcription and enhancer-associated RNAs in Drosophila melanogaster. BMC Genomics. 2018 02 21; 19(1):157. PMID: 29466941.
    Citations: 1     Fields:    Translation:AnimalsCells
  14. Henriques T, Scruggs BS, Inouye MO, Muse GW, Williams LH, Burkholder AB, Lavender CA, Fargo DC, Adelman K. Widespread transcriptional pausing and elongation control at enhancers. Genes Dev. 2018 01 01; 32(1):26-41. PMID: 29378787.
    Citations: 13     Fields:    Translation:AnimalsCells
  15. Pai AA, Henriques T, McCue K, Burkholder A, Adelman K, Burge CB. The kinetics of pre-mRNA splicing in the Drosophila genome and the influence of gene architecture. Elife. 2017 12 27; 6. PMID: 29280736.
    Citations: 1     Fields:    Translation:AnimalsCells
  16. Urban J, Kuzu G, Bowman S, Scruggs B, Henriques T, Kingston R, Adelman K, Tolstorukov M, Larschan E. Enhanced chromatin accessibility of the dosage compensated Drosophila male X-chromosome requires the CLAMP zinc finger protein. PLoS One. 2017; 12(10):e0186855. PMID: 29077765.
    Citations: 1     Fields:    Translation:AnimalsCells
  17. Cinghu S, Yang P, Kosak JP, Conway AE, Kumar D, Oldfield AJ, Adelman K, Jothi R. Intragenic Enhancers Attenuate Host Gene Expression. Mol Cell. 2017 Oct 05; 68(1):104-117.e6. PMID: 28985501.
    Citations: 6     Fields:    Translation:AnimalsCells
  18. Lavender CA, Shapiro AJ, Burkholder AB, Bennett BD, Adelman K, Fargo DC. ORIO (Online Resource for Integrative Omics): a web-based platform for rapid integration of next generation sequencing data. Nucleic Acids Res. 2017 Jun 02; 45(10):5678-5690. PMID: 28402545.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  19. Dorighi KM, Swigut T, Henriques T, Bhanu NV, Scruggs BS, Nady N, Still CD, Garcia BA, Adelman K, Wysocka J. Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation. Mol Cell. 2017 May 18; 66(4):568-576.e4. PMID: 28483418.
    Citations: 25     Fields:    Translation:AnimalsCells
  20. Meers MP, Henriques T, Lavender CA, McKay DJ, Strahl BD, Duronio RJ, Adelman K, Matera AG. Histone gene replacement reveals a post-transcriptional role for H3K36 in maintaining metazoan transcriptome fidelity. Elife. 2017 03 27; 6. PMID: 28346137.
    Citations:    Fields:    Translation:AnimalsCells
  21. Adelman K, Egan E. Non-coding RNA: More uses for genomic junk. Nature. 2017 03 08; 543(7644):183-185. PMID: 28277509.
    Citations: 1     Fields:    Translation:Humans
  22. Scruggs BS, Gilchrist DA, Nechaev S, Muse GW, Burkholder A, Fargo DC, Adelman K. Bidirectional Transcription Arises from Two Distinct Hubs of Transcription Factor Binding and Active Chromatin. Mol Cell. 2015 Jun 18; 58(6):1101-12. PMID: 26028540.
    Citations: 48     Fields:    Translation:AnimalsCells
  23. Williams LH, Fromm G, Gokey NG, Henriques T, Muse GW, Burkholder A, Fargo DC, Hu G, Adelman K. Pausing of RNA polymerase II regulates mammalian developmental potential through control of signaling networks. Mol Cell. 2015 Apr 16; 58(2):311-322. PMID: 25773599.
    Citations: 36     Fields:    Translation:AnimalsCells
  24. Scruggs BS, Adelman K. The Importance of Controlling Transcription Elongation at Coding and Noncoding RNA Loci. Cold Spring Harb Symp Quant Biol. 2015; 80:33-44. PMID: 27325707.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  25. Rogatsky I, Adelman K. Preparing the first responders: building the inflammatory transcriptome from the ground up. Mol Cell. 2014 Apr 24; 54(2):245-54. PMID: 24766888.
    Citations: 13     Fields:    Translation:Cells
  26. Schröder S, Herker E, Itzen F, He D, Thomas S, Gilchrist DA, Kaehlcke K, Cho S, Pollard KS, Capra JA, Schnölzer M, Cole PA, Geyer M, Bruneau BG, Adelman K, Ott M. Acetylation of RNA polymerase II regulates growth-factor-induced gene transcription in mammalian cells. Mol Cell. 2013 Nov 07; 52(3):314-24. PMID: 24207025.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  27. Henriques T, Gilchrist DA, Nechaev S, Bern M, Muse GW, Burkholder A, Fargo DC, Adelman K. Stable pausing by RNA polymerase II provides an opportunity to target and integrate regulatory signals. Mol Cell. 2013 Nov 21; 52(4):517-28. PMID: 24184211.
    Citations: 61     Fields:    Translation:AnimalsCells
  28. Gupte R, Muse GW, Chinenov Y, Adelman K, Rogatsky I. Glucocorticoid receptor represses proinflammatory genes at distinct steps of the transcription cycle. Proc Natl Acad Sci U S A. 2013 Sep 03; 110(36):14616-21. PMID: 23950223.
    Citations: 21     Fields:    Translation:AnimalsCells
  29. Fromm G, Gilchrist DA, Adelman K. SnapShot: Transcription regulation: pausing. Cell. 2013 May 09; 153(4):930-930.e1. PMID: 23663787.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  30. Henriques T, Adelman K. Catching the waves: following the leading edge of elongating RNA polymerase II. Mol Cell. 2013 Apr 25; 50(2):159-60. PMID: 23622514.
    Citations: 1     Fields:    
  31. Core LJ, Waterfall JJ, Gilchrist DA, Fargo DC, Kwak H, Adelman K, Lis JT. Defining the status of RNA polymerase at promoters. Cell Rep. 2012 Oct 25; 2(4):1025-35. PMID: 23062713.
    Citations: 90     Fields:    Translation:AnimalsCells
  32. Adelman K, Lis JT. Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans. Nat Rev Genet. 2012 Oct; 13(10):720-31. PMID: 22986266.
    Citations: 316     Fields:    Translation:HumansAnimalsCells
  33. Gilchrist DA, Fromm G, dos Santos G, Pham LN, McDaniel IE, Burkholder A, Fargo DC, Adelman K. Regulating the regulators: the pervasive effects of Pol II pausing on stimulus-responsive gene networks. Genes Dev. 2012 May 01; 26(9):933-44. PMID: 22549956.
    Citations: 58     Fields:    Translation:AnimalsCells
  34. Gilchrist DA, Adelman K. Coupling polymerase pausing and chromatin landscapes for precise regulation of transcription. Biochim Biophys Acta. 2012 Jul; 1819(7):700-6. PMID: 22406341.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  35. Saha RN, Wissink EM, Bailey ER, Zhao M, Fargo DC, Hwang JY, Daigle KR, Fenn JD, Adelman K, Dudek SM. Rapid activity-induced transcription of Arc and other IEGs relies on poised RNA polymerase II. Nat Neurosci. 2011 May 29; 14(7):848-56. PMID: 21623364.
    Citations: 61     Fields:    Translation:AnimalsCells
  36. Nechaev S, Adelman K. Pol II waiting in the starting gates: Regulating the transition from transcription initiation into productive elongation. Biochim Biophys Acta. 2011 Jan; 1809(1):34-45. PMID: 21081187.
    Citations: 132     Fields:    Translation:HumansCells
  37. Gilchrist DA, Dos Santos G, Fargo DC, Xie B, Gao Y, Li L, Adelman K. Pausing of RNA polymerase II disrupts DNA-specified nucleosome organization to enable precise gene regulation. Cell. 2010 Nov 12; 143(4):540-51. PMID: 21074046.
    Citations: 189     Fields:    Translation:AnimalsCells
  38. Bartkowiak B, Liu P, Phatnani HP, Fuda NJ, Cooper JJ, Price DH, Adelman K, Lis JT, Greenleaf AL. CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1. Genes Dev. 2010 Oct 15; 24(20):2303-16. PMID: 20952539.
    Citations: 130     Fields:    Translation:HumansAnimalsCells
  39. Gilchrist DA, Adelman K. Moonshine illuminates a developmental role for regulated transcription elongation. Dev Cell. 2010 Jul 20; 19(1):9-10. PMID: 20643345.
    Citations:    Fields:    
  40. Fromm G, Adelman K. Taking MLL through the MudPIT: identification of novel complexes that bring together MLL-fusion proteins and transcription elongation factors. Mol Cell. 2010 Feb 26; 37(4):449-50. PMID: 20188661.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  41. Adelman K, Rogatsky I. RNA polymerase II stalling mediates cytokine gene expression. Cell Cycle. 2010 Feb 15; 9(4):630-1. PMID: 20107307.
    Citations: 5     Fields:    Translation:Cells
  42. Nechaev S, Fargo DC, dos Santos G, Liu L, Gao Y, Adelman K. Global analysis of short RNAs reveals widespread promoter-proximal stalling and arrest of Pol II in Drosophila. Science. 2010 Jan 15; 327(5963):335-8. PMID: 20007866.
    Citations: 190     Fields:    Translation:AnimalsCells
  43. Adelman K, Kennedy MA, Nechaev S, Gilchrist DA, Muse GW, Chinenov Y, Rogatsky I. Immediate mediators of the inflammatory response are poised for gene activation through RNA polymerase II stalling. Proc Natl Acad Sci U S A. 2009 Oct 27; 106(43):18207-12. PMID: 19820169.
    Citations: 64     Fields:    Translation:AnimalsCells
  44. Ardehali MB, Yao J, Adelman K, Fuda NJ, Petesch SJ, Webb WW, Lis JT. Spt6 enhances the elongation rate of RNA polymerase II in vivo. EMBO J. 2009 Apr 22; 28(8):1067-77. PMID: 19279664.
    Citations: 60     Fields:    Translation:AnimalsCells
  45. Gilchrist DA, Fargo DC, Adelman K. Using ChIP-chip and ChIP-seq to study the regulation of gene expression: genome-wide localization studies reveal widespread regulation of transcription elongation. Methods. 2009 Aug; 48(4):398-408. PMID: 19275938.
    Citations: 25     Fields:    Translation:Cells
  46. Gilchrist DA, Nechaev S, Lee C, Ghosh SK, Collins JB, Li L, Gilmour DS, Adelman K. NELF-mediated stalling of Pol II can enhance gene expression by blocking promoter-proximal nucleosome assembly. Genes Dev. 2008 Jul 15; 22(14):1921-33. PMID: 18628398.
    Citations: 139     Fields:    Translation:AnimalsCells
  47. Nechaev S, Adelman K. Promoter-proximal Pol II: when stalling speeds things up. Cell Cycle. 2008 Jun 01; 7(11):1539-44. PMID: 18469524.
    Citations: 53     Fields:    Translation:AnimalsCells
  48. Zeitlinger J, Stark A, Kellis M, Hong JW, Nechaev S, Adelman K, Levine M, Young RA. RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryo. Nat Genet. 2007 Dec; 39(12):1512-6. PMID: 17994019.
    Citations: 377     Fields:    Translation:Animals
  49. Muse GW, Gilchrist DA, Nechaev S, Shah R, Parker JS, Grissom SF, Zeitlinger J, Adelman K. RNA polymerase is poised for activation across the genome. Nat Genet. 2007 Dec; 39(12):1507-11. PMID: 17994021.
    Citations: 387     Fields:    Translation:AnimalsCells
  50. Adelman K, Wei W, Ardehali MB, Werner J, Zhu B, Reinberg D, Lis JT. Drosophila Paf1 modulates chromatin structure at actively transcribed genes. Mol Cell Biol. 2006 Jan; 26(1):250-60. PMID: 16354696.
    Citations: 58     Fields:    Translation:AnimalsCells
  51. Adelman K, Marr MT, Werner J, Saunders A, Ni Z, Andrulis ED, Lis JT. Efficient release from promoter-proximal stall sites requires transcript cleavage factor TFIIS. Mol Cell. 2005 Jan 07; 17(1):103-12. PMID: 15629721.
    Citations: 79     Fields:    Translation:AnimalsCells
  52. Adelman K, Yuzenkova J, La Porta A, Zenkin N, Lee J, Lis JT, Borukhov S, Wang MD, Severinov K. Molecular mechanism of transcription inhibition by peptide antibiotic Microcin J25. Mol Cell. 2004 Jun 18; 14(6):753-62. PMID: 15200953.
    Citations: 30     Fields:    Translation:Cells
  53. Fan X, Shi H, Adelman K, Lis JT. Probing TBP interactions in transcription initiation and reinitiation with RNA aptamers that act in distinct modes. Proc Natl Acad Sci U S A. 2004 May 04; 101(18):6934-9. PMID: 15103022.
    Citations: 16     Fields:    Translation:Cells
  54. Simeonov MF, Bieber Urbauer RJ, Gilmore JM, Adelman K, Brody EN, Niedziela-Majka A, Minakhin L, Heyduk T, Urbauer JL. Characterization of the interactions between the bacteriophage T4 AsiA protein and RNA polymerase. Biochemistry. 2003 Jul 01; 42(25):7717-26. PMID: 12820881.
    Citations: 11     Fields:    Translation:Cells
  55. Minakhin L, Niedziela-Majka A, Kuznedelov K, Adelman K, Urbauer JL, Heyduk T, Severinov K. Interaction of T4 AsiA with its target sites in the RNA polymerase sigma70 subunit leads to distinct and opposite effects on transcription. J Mol Biol. 2003 Feb 21; 326(3):679-90. PMID: 12581632.
    Citations: 8     Fields:    Translation:Cells
  56. Adelman K, La Porta A, Santangelo TJ, Lis JT, Roberts JW, Wang MD. Single molecule analysis of RNA polymerase elongation reveals uniform kinetic behavior. Proc Natl Acad Sci U S A. 2002 Oct 15; 99(21):13538-43. PMID: 12370445.
    Citations: 65     Fields:    Translation:Cells
  57. Adelman K, Lis JT. How does Pol II overcome the nucleosome barrier? Mol Cell. 2002 Mar; 9(3):451-2. PMID: 11931751.
    Citations: 2     Fields:    Translation:Cells
  58. Urbauer JL, Simeonov MF, Urbauer RJ, Adelman K, Gilmore JM, Brody EN. Solution structure and stability of the anti-sigma factor AsiA: implications for novel functions. Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):1831-5. PMID: 11830637.
    Citations: 12     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.