Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Karen Adelman, Ph.D.

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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01GM139960 (ADELMAN, KAREN L) Jan 1, 2021 - Dec 31, 2024
    NIH
    Identifying the sequences and factors that govern the fate of elongating RNAPII
    Role: Principal Investigator
  2. R01GM134539 (ADELMAN, KAREN L) Aug 15, 2019 - Jul 31, 2023
    NIH
    Probing the specificity and activity of the metazoan Integrator complex
    Role: Principal Investigator
  3. F32GM066661 (ADELMAN, KAREN L) Aug 1, 2002 - Jul 31, 2005
    NIH
    Single molecule analyses of RNA polymerase II elongation
    Role: Principal Investigator
  4. Z01ES101987 (ADELMAN, KAREN L)
    NIH
    Investigating Transcriptional Responses to the Environment
    Role: Principal Investigator
  5. ZIAES101987 (ADELMAN, KAREN L)
    NIH
    Investigating Transcriptional Responses to the Environment
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Rambout X, Cho H, Blanc R, Lyu Q, Miano JM, Chakkalakal JV, Nelson GM, Yalamanchili HK, Adelman K, Maquat LE. PGC-1a senses the CBC of pre-mRNA to dictate the fate of promoter-proximally paused RNAPII. Mol Cell. 2023 Jan 19; 83(2):186-202.e11. PMID: 36669479; PMCID: PMC9951270.
    Citations:    Fields:    Translation:AnimalsCells
  2. Wagner EJ, Tong L, Adelman K. Integrator is a global promoter-proximal termination complex. Mol Cell. 2023 02 02; 83(3):416-427. PMID: 36634676.
    Citations:    Fields:    Translation:HumansAnimalsCells
  3. Luppino JM, Field A, Nguyen SC, Park DS, Shah PP, Abdill RJ, Lan Y, Yunker R, Jain R, Adelman K, Joyce EF. Co-depletion of NIPBL and WAPL balance cohesin activity to correct gene misexpression. PLoS Genet. 2022 11; 18(11):e1010528. PMID: 36449519; PMCID: PMC9744307.
    Citations:    Fields:    Translation:HumansCells
  4. Stein CB, Field AR, Mimoso CA, Zhao C, Huang KL, Wagner EJ, Adelman K. Integrator endonuclease drives promoter-proximal termination at all RNA polymerase II-transcribed loci. Mol Cell. 2022 11 17; 82(22):4232-4245.e11. PMID: 36309014; PMCID: PMC9680917.
    Citations: 1     Fields:    Translation:Cells
  5. Mehta S, Buyanbat A, Kai Y, Karayel O, Goldman SR, Seruggia D, Zhang K, Fujiwara Y, Donovan KA, Zhu Q, Yang H, Nabet B, Gray NS, Mann M, Fischer ES, Adelman K, Orkin SH. Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells. Cell Chem Biol. 2022 08 18; 29(8):1273-1287.e8. PMID: 35839780; PMCID: PMC9391307.
    Citations:    Fields:    
  6. Vlaming H, Mimoso CA, Field AR, Martin BJE, Adelman K. Screening thousands of transcribed coding and non-coding regions reveals sequence determinants of RNA polymerase II elongation potential. Nat Struct Mol Biol. 2022 06; 29(6):613-620. PMID: 35681023; PMCID: PMC9672417.
    Citations:    Fields:    Translation:Cells
  7. Replogle JM, Saunders RA, Pogson AN, Hussmann JA, Lenail A, Guna A, Mascibroda L, Wagner EJ, Adelman K, Lithwick-Yanai G, Iremadze N, Oberstrass F, Lipson D, Bonnar JL, Jost M, Norman TM, Weissman JS. Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq. Cell. 2022 07 07; 185(14):2559-2575.e28. PMID: 35688146; PMCID: PMC9380471.
    Citations:    Fields:    
  8. Wu W, Nelson GM, Koch R, Donovan KA, Nowak RP, Heavican-Foral TB, Nirmal AJ, Liu H, Yang L, Duffy J, Powers F, Stevenson KE, Jones MK, Ng SY, Wu G, Jain S, Xu R, Amaka S, Trevisani C, Donaldson NL, Hagner PR, de Leval L, Gaulard P, Iqbal J, Thakurta A, Fischer ES, Adelman K, Weinstock DM. Overcoming IMiD resistance in T-cell lymphomas through potent degradation of ZFP91 and IKZF1. Blood. 2022 03 31; 139(13):2024-2037. PMID: 34936696; PMCID: PMC8972091.
    Citations:    Fields:    Translation:HumansCells
  9. Zhou H, Stein CB, Shafiq TA, Shipkovenska G, Kalocsay M, Paulo JA, Zhang J, Luo Z, Gygi SP, Adelman K, Moazed D. Rixosomal RNA degradation contributes to silencing of Polycomb target genes. Nature. 2022 04; 604(7904):167-174. PMID: 35355014; PMCID: PMC8986528.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  10. Adelman K. Nascent transcription as a predictor and driver of histone modifications. Nat Genet. 2022 03; 54(3):223-224. PMID: 35273400.
    Citations:    Fields:    Translation:Cells
  11. Xu W, He C, Kaye EG, Li J, Mu M, Nelson GM, Dong L, Wang J, Wu F, Shi YG, Adelman K, Lan F, Shi Y, Shen H. Dynamic control of chromatin-associated m6A methylation regulates nascent RNA synthesis. Mol Cell. 2022 03 17; 82(6):1156-1168.e7. PMID: 35219383; PMCID: PMC8969783.
    Citations: 3     Fields:    Translation:Cells
  12. Cermakova K, Demeulemeester J, Lux V, Nedomova M, Goldman SR, Smith EA, Srb P, Hexnerova R, Fabry M, Madlikova M, Horejsi M, De Rijck J, Debyser Z, Adelman K, Hodges HC, Veverka V. A ubiquitous disordered protein interaction module orchestrates transcription elongation. Science. 2021 Nov 26; 374(6571):1113-1121. PMID: 34822292; PMCID: PMC8943916.
    Citations: 1     Fields:    Translation:HumansCells
  13. Adelman K, Martin BJE. ecDNA party bus: Bringing the enhancer to you. Mol Cell. 2021 05 06; 81(9):1866-1867. PMID: 33961776.
    Citations: 2     Fields:    Translation:HumansCells
  14. Robinson DCL, Ritso M, Nelson GM, Mokhtari Z, Nakka K, Bandukwala H, Goldman SR, Park PJ, Mounier R, Chazaud B, Brand M, Rudnicki MA, Adelman K, Dilworth FJ. Negative elongation factor regulates muscle progenitor expansion for efficient myofiber repair and stem cell pool repopulation. Dev Cell. 2021 04 05; 56(7):1014-1029.e7. PMID: 33735618.
    Citations: 7     Fields:    Translation:AnimalsCells
  15. Reimer KA, Mimoso CA, Adelman K, Neugebauer KM. Co-transcriptional splicing regulates 3' end cleavage during mammalian erythropoiesis. Mol Cell. 2021 03 04; 81(5):998-1012.e7. PMID: 33440169; PMCID: PMC8038867.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  16. Huang KL, Jee D, Stein CB, Elrod ND, Henriques T, Mascibroda LG, Baillat D, Russell WK, Adelman K, Wagner EJ. Integrator Recruits Protein Phosphatase 2A to Prevent Pause Release and Facilitate Transcription Termination. Mol Cell. 2020 10 15; 80(2):345-358.e9. PMID: 32966759.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  17. Rogers JM, Guo B, Egan ED, Aster JC, Adelman K, Blacklow SC. MAML1-Dependent Notch-Responsive Genes Exhibit Differing Cofactor Requirements for Transcriptional Activation. Mol Cell Biol. 2020 05 14; 40(11). PMID: 32179552.
    Citations: 1     Fields:    Translation:HumansCells
  18. Santoriello C, Sporrij A, Yang S, Flynn RA, Henriques T, Dorjsuren B, Custo Greig E, McCall W, Stanhope ME, Fazio M, Superdock M, Lichtig A, Adatto I, Abraham BJ, Kalocsay M, Jurynec M, Zhou Y, Adelman K, Calo E, Zon LI. RNA helicase DDX21 mediates nucleotide stress responses in neural crest and melanoma cells. Nat Cell Biol. 2020 04; 22(4):372-379. PMID: 32231306; PMCID: PMC7185069.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  19. Field A, Adelman K. Evaluating Enhancer Function and Transcription. Annu Rev Biochem. 2020 06 20; 89:213-234. PMID: 32197056.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  20. Elrod ND, Henriques T, Huang KL, Tatomer DC, Wilusz JE, Wagner EJ, Adelman K. The Integrator Complex Attenuates Promoter-Proximal Transcription at Protein-Coding Genes. Mol Cell. 2019 12 05; 76(5):738-752.e7. PMID: 31809743.
    Citations: 44     Fields:    Translation:AnimalsCells
  21. Etchegaray JP, Zhong L, Li C, Henriques T, Ablondi E, Nakadai T, Van Rechem C, Ferrer C, Ross KN, Choi JE, Samarakkody A, Ji F, Chang A, Sadreyev RI, Ramaswamy S, Nechaev S, Whetstine JR, Roeder RG, Adelman K, Goren A, Mostoslavsky R. The Histone Deacetylase SIRT6 Restrains Transcription Elongation via Promoter-Proximal Pausing. Mol Cell. 2019 08 22; 75(4):683-699.e7. PMID: 31399344.
    Citations: 22     Fields:    Translation:HumansCells
  22. Oldfield AJ, Henriques T, Kumar D, Burkholder AB, Cinghu S, Paulet D, Bennett BD, Yang P, Scruggs BS, Lavender CA, Rivals E, Adelman K, Jothi R. NF-Y controls fidelity of transcription initiation at gene promoters through maintenance of the nucleosome-depleted region. Nat Commun. 2019 07 11; 10(1):3072. PMID: 31296853.
    Citations: 18     Fields:    Translation:AnimalsCells
  23. Sendinc E, Valle-Garcia D, Dhall A, Chen H, Henriques T, Navarrete-Perea J, Sheng W, Gygi SP, Adelman K, Shi Y. PCIF1 Catalyzes m6Am mRNA Methylation to Regulate Gene Expression. Mol Cell. 2019 08 08; 75(3):620-630.e9. PMID: 31279659; PMCID: PMC6688901.
    Citations: 72     Fields:    Translation:HumansCells
  24. Core L, Adelman K. Promoter-proximal pausing of RNA polymerase II: a nexus of gene regulation. Genes Dev. 2019 08 01; 33(15-16):960-982. PMID: 31123063; PMCID: PMC6672056.
    Citations: 105     Fields:    Translation:HumansAnimalsCells
  25. Hewitt SC, Li R, Adams N, Winuthayanon W, Hamilton KJ, Donoghue LJ, Lierz SL, Garcia M, Lydon JP, DeMayo FJ, Adelman K, Korach KS. Negative elongation factor is essential for endometrial function. FASEB J. 2019 02; 33(2):3010-3023. PMID: 30332301; PMCID: PMC6338652.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  26. Pai AA, Paggi JM, Yan P, Adelman K, Burge CB. Numerous recursive sites contribute to accuracy of splicing in long introns in flies. PLoS Genet. 2018 08; 14(8):e1007588. PMID: 30148878; PMCID: PMC6110457.
    Citations: 6     Fields:    Translation:AnimalsCells
  27. Adelman K, Henriques T. Transcriptional speed bumps revealed in high resolution. Nature. 2018 08; 560(7720):560-561. PMID: 30143755.
    Citations: 3     Fields:    
  28. Kaikkonen MU, Adelman K. Emerging Roles of Non-Coding RNA Transcription. Trends Biochem Sci. 2018 09; 43(9):654-667. PMID: 30145998.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  29. Meers MP, Adelman K, Duronio RJ, Strahl BD, McKay DJ, Matera AG. Transcription start site profiling uncovers divergent transcription and enhancer-associated RNAs in Drosophila melanogaster. BMC Genomics. 2018 02 21; 19(1):157. PMID: 29466941.
    Citations: 13     Fields:    Translation:AnimalsCells
  30. Henriques T, Scruggs BS, Inouye MO, Muse GW, Williams LH, Burkholder AB, Lavender CA, Fargo DC, Adelman K. Widespread transcriptional pausing and elongation control at enhancers. Genes Dev. 2018 01 01; 32(1):26-41. PMID: 29378787.
    Citations: 134     Fields:    Translation:AnimalsCells
  31. Pai AA, Henriques T, McCue K, Burkholder A, Adelman K, Burge CB. The kinetics of pre-mRNA splicing in the Drosophila genome and the influence of gene architecture. Elife. 2017 12 27; 6. PMID: 29280736.
    Citations: 26     Fields:    Translation:AnimalsCells
  32. Urban J, Kuzu G, Bowman S, Scruggs B, Henriques T, Kingston R, Adelman K, Tolstorukov M, Larschan E. Enhanced chromatin accessibility of the dosage compensated Drosophila male X-chromosome requires the CLAMP zinc finger protein. PLoS One. 2017; 12(10):e0186855. PMID: 29077765.
    Citations: 14     Fields:    Translation:AnimalsCells
  33. Cinghu S, Yang P, Kosak JP, Conway AE, Kumar D, Oldfield AJ, Adelman K, Jothi R. Intragenic Enhancers Attenuate Host Gene Expression. Mol Cell. 2017 Oct 05; 68(1):104-117.e6. PMID: 28985501.
    Citations: 42     Fields:    Translation:AnimalsCells
  34. Lavender CA, Shapiro AJ, Burkholder AB, Bennett BD, Adelman K, Fargo DC. ORIO (Online Resource for Integrative Omics): a web-based platform for rapid integration of next generation sequencing data. Nucleic Acids Res. 2017 Jun 02; 45(10):5678-5690. PMID: 28402545; PMCID: PMC5449597.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  35. Dorighi KM, Swigut T, Henriques T, Bhanu NV, Scruggs BS, Nady N, Still CD, Garcia BA, Adelman K, Wysocka J. Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation. Mol Cell. 2017 May 18; 66(4):568-576.e4. PMID: 28483418; PMCID: PMC5662137.
    Citations: 135     Fields:    Translation:AnimalsCells
  36. Meers MP, Henriques T, Lavender CA, McKay DJ, Strahl BD, Duronio RJ, Adelman K, Matera AG. Histone gene replacement reveals a post-transcriptional role for H3K36 in maintaining metazoan transcriptome fidelity. Elife. 2017 03 27; 6. PMID: 28346137.
    Citations: 18     Fields:    Translation:AnimalsCells
  37. Adelman K, Egan E. Non-coding RNA: More uses for genomic junk. Nature. 2017 03 08; 543(7644):183-185. PMID: 28277509.
    Citations: 26     Fields:    Translation:Humans
  38. Scruggs BS, Gilchrist DA, Nechaev S, Muse GW, Burkholder A, Fargo DC, Adelman K. Bidirectional Transcription Arises from Two Distinct Hubs of Transcription Factor Binding and Active Chromatin. Mol Cell. 2015 Jun 18; 58(6):1101-12. PMID: 26028540.
    Citations: 113     Fields:    Translation:AnimalsCells
  39. Williams LH, Fromm G, Gokey NG, Henriques T, Muse GW, Burkholder A, Fargo DC, Hu G, Adelman K. Pausing of RNA polymerase II regulates mammalian developmental potential through control of signaling networks. Mol Cell. 2015 Apr 16; 58(2):311-322. PMID: 25773599; PMCID: PMC4402150.
    Citations: 83     Fields:    Translation:AnimalsCells
  40. Scruggs BS, Adelman K. The Importance of Controlling Transcription Elongation at Coding and Noncoding RNA Loci. Cold Spring Harb Symp Quant Biol. 2015; 80:33-44. PMID: 27325707; PMCID: PMC6499063.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  41. Rogatsky I, Adelman K. Preparing the first responders: building the inflammatory transcriptome from the ground up. Mol Cell. 2014 Apr 24; 54(2):245-54. PMID: 24766888.
    Citations: 23     Fields:    Translation:Cells
  42. Schröder S, Herker E, Itzen F, He D, Thomas S, Gilchrist DA, Kaehlcke K, Cho S, Pollard KS, Capra JA, Schnölzer M, Cole PA, Geyer M, Bruneau BG, Adelman K, Ott M. Acetylation of RNA polymerase II regulates growth-factor-induced gene transcription in mammalian cells. Mol Cell. 2013 Nov 07; 52(3):314-24. PMID: 24207025.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  43. Henriques T, Gilchrist DA, Nechaev S, Bern M, Muse GW, Burkholder A, Fargo DC, Adelman K. Stable pausing by RNA polymerase II provides an opportunity to target and integrate regulatory signals. Mol Cell. 2013 Nov 21; 52(4):517-28. PMID: 24184211.
    Citations: 119     Fields:    Translation:AnimalsCells
  44. Gupte R, Muse GW, Chinenov Y, Adelman K, Rogatsky I. Glucocorticoid receptor represses proinflammatory genes at distinct steps of the transcription cycle. Proc Natl Acad Sci U S A. 2013 Sep 03; 110(36):14616-21. PMID: 23950223.
    Citations: 37     Fields:    Translation:AnimalsCells
  45. Fromm G, Gilchrist DA, Adelman K. SnapShot: Transcription regulation: pausing. Cell. 2013 May 09; 153(4):930-930.e1. PMID: 23663787.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  46. Henriques T, Adelman K. Catching the waves: following the leading edge of elongating RNA polymerase II. Mol Cell. 2013 Apr 25; 50(2):159-60. PMID: 23622514.
    Citations: 2     Fields:    
  47. Core LJ, Waterfall JJ, Gilchrist DA, Fargo DC, Kwak H, Adelman K, Lis JT. Defining the status of RNA polymerase at promoters. Cell Rep. 2012 Oct 25; 2(4):1025-35. PMID: 23062713.
    Citations: 138     Fields:    Translation:AnimalsCells
  48. Adelman K, Lis JT. Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans. Nat Rev Genet. 2012 Oct; 13(10):720-31. PMID: 22986266.
    Citations: 573     Fields:    Translation:HumansAnimalsCells
  49. Gilchrist DA, Fromm G, dos Santos G, Pham LN, McDaniel IE, Burkholder A, Fargo DC, Adelman K. Regulating the regulators: the pervasive effects of Pol II pausing on stimulus-responsive gene networks. Genes Dev. 2012 May 01; 26(9):933-44. PMID: 22549956.
    Citations: 77     Fields:    Translation:AnimalsCells
  50. Gilchrist DA, Adelman K. Coupling polymerase pausing and chromatin landscapes for precise regulation of transcription. Biochim Biophys Acta. 2012 Jul; 1819(7):700-6. PMID: 22406341.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  51. Saha RN, Wissink EM, Bailey ER, Zhao M, Fargo DC, Hwang JY, Daigle KR, Fenn JD, Adelman K, Dudek SM. Rapid activity-induced transcription of Arc and other IEGs relies on poised RNA polymerase II. Nat Neurosci. 2011 May 29; 14(7):848-56. PMID: 21623364.
    Citations: 96     Fields:    Translation:AnimalsCells
  52. Nechaev S, Adelman K. Pol II waiting in the starting gates: Regulating the transition from transcription initiation into productive elongation. Biochim Biophys Acta. 2011 Jan; 1809(1):34-45. PMID: 21081187.
    Citations: 158     Fields:    Translation:HumansCells
  53. Gilchrist DA, Dos Santos G, Fargo DC, Xie B, Gao Y, Li L, Adelman K. Pausing of RNA polymerase II disrupts DNA-specified nucleosome organization to enable precise gene regulation. Cell. 2010 Nov 12; 143(4):540-51. PMID: 21074046.
    Citations: 258     Fields:    Translation:AnimalsCells
  54. Bartkowiak B, Liu P, Phatnani HP, Fuda NJ, Cooper JJ, Price DH, Adelman K, Lis JT, Greenleaf AL. CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1. Genes Dev. 2010 Oct 15; 24(20):2303-16. PMID: 20952539.
    Citations: 197     Fields:    Translation:HumansAnimalsCells
  55. Gilchrist DA, Adelman K. Moonshine illuminates a developmental role for regulated transcription elongation. Dev Cell. 2010 Jul 20; 19(1):9-10. PMID: 20643345.
    Citations: 1     Fields:    
  56. Fromm G, Adelman K. Taking MLL through the MudPIT: identification of novel complexes that bring together MLL-fusion proteins and transcription elongation factors. Mol Cell. 2010 Feb 26; 37(4):449-50. PMID: 20188661.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  57. Adelman K, Rogatsky I. RNA polymerase II stalling mediates cytokine gene expression. Cell Cycle. 2010 Feb 15; 9(4):630-1. PMID: 20107307.
    Citations: 5     Fields:    Translation:Cells
  58. Nechaev S, Fargo DC, dos Santos G, Liu L, Gao Y, Adelman K. Global analysis of short RNAs reveals widespread promoter-proximal stalling and arrest of Pol II in Drosophila. Science. 2010 Jan 15; 327(5963):335-8. PMID: 20007866.
    Citations: 262     Fields:    Translation:AnimalsCells
  59. Adelman K, Kennedy MA, Nechaev S, Gilchrist DA, Muse GW, Chinenov Y, Rogatsky I. Immediate mediators of the inflammatory response are poised for gene activation through RNA polymerase II stalling. Proc Natl Acad Sci U S A. 2009 Oct 27; 106(43):18207-12. PMID: 19820169.
    Citations: 87     Fields:    Translation:AnimalsCells
  60. Ardehali MB, Yao J, Adelman K, Fuda NJ, Petesch SJ, Webb WW, Lis JT. Spt6 enhances the elongation rate of RNA polymerase II in vivo. EMBO J. 2009 Apr 22; 28(8):1067-77. PMID: 19279664.
    Citations: 89     Fields:    Translation:AnimalsCells
  61. Gilchrist DA, Fargo DC, Adelman K. Using ChIP-chip and ChIP-seq to study the regulation of gene expression: genome-wide localization studies reveal widespread regulation of transcription elongation. Methods. 2009 Aug; 48(4):398-408. PMID: 19275938.
    Citations: 29     Fields:    Translation:Cells
  62. Gilchrist DA, Nechaev S, Lee C, Ghosh SK, Collins JB, Li L, Gilmour DS, Adelman K. NELF-mediated stalling of Pol II can enhance gene expression by blocking promoter-proximal nucleosome assembly. Genes Dev. 2008 Jul 15; 22(14):1921-33. PMID: 18628398.
    Citations: 177     Fields:    Translation:AnimalsCells
  63. Nechaev S, Adelman K. Promoter-proximal Pol II: when stalling speeds things up. Cell Cycle. 2008 Jun 01; 7(11):1539-44. PMID: 18469524.
    Citations: 57     Fields:    Translation:AnimalsCells
  64. Zeitlinger J, Stark A, Kellis M, Hong JW, Nechaev S, Adelman K, Levine M, Young RA. RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryo. Nat Genet. 2007 Dec; 39(12):1512-6. PMID: 17994019.
    Citations: 450     Fields:    Translation:Animals
  65. Muse GW, Gilchrist DA, Nechaev S, Shah R, Parker JS, Grissom SF, Zeitlinger J, Adelman K. RNA polymerase is poised for activation across the genome. Nat Genet. 2007 Dec; 39(12):1507-11. PMID: 17994021.
    Citations: 460     Fields:    Translation:AnimalsCells
  66. Adelman K, Wei W, Ardehali MB, Werner J, Zhu B, Reinberg D, Lis JT. Drosophila Paf1 modulates chromatin structure at actively transcribed genes. Mol Cell Biol. 2006 Jan; 26(1):250-60. PMID: 16354696; PMCID: PMC1317635.
    Citations: 72     Fields:    Translation:AnimalsCells
  67. Adelman K, Marr MT, Werner J, Saunders A, Ni Z, Andrulis ED, Lis JT. Efficient release from promoter-proximal stall sites requires transcript cleavage factor TFIIS. Mol Cell. 2005 Jan 07; 17(1):103-12. PMID: 15629721.
    Citations: 100     Fields:    Translation:AnimalsCells
  68. Adelman K, Yuzenkova J, La Porta A, Zenkin N, Lee J, Lis JT, Borukhov S, Wang MD, Severinov K. Molecular mechanism of transcription inhibition by peptide antibiotic Microcin J25. Mol Cell. 2004 Jun 18; 14(6):753-62. PMID: 15200953.
    Citations: 51     Fields:    Translation:Cells
  69. Fan X, Shi H, Adelman K, Lis JT. Probing TBP interactions in transcription initiation and reinitiation with RNA aptamers that act in distinct modes. Proc Natl Acad Sci U S A. 2004 May 04; 101(18):6934-9. PMID: 15103022; PMCID: PMC406445.
    Citations: 18     Fields:    Translation:Cells
  70. Simeonov MF, Bieber Urbauer RJ, Gilmore JM, Adelman K, Brody EN, Niedziela-Majka A, Minakhin L, Heyduk T, Urbauer JL. Characterization of the interactions between the bacteriophage T4 AsiA protein and RNA polymerase. Biochemistry. 2003 Jul 01; 42(25):7717-26. PMID: 12820881.
    Citations: 12     Fields:    Translation:Cells
  71. Minakhin L, Niedziela-Majka A, Kuznedelov K, Adelman K, Urbauer JL, Heyduk T, Severinov K. Interaction of T4 AsiA with its target sites in the RNA polymerase sigma70 subunit leads to distinct and opposite effects on transcription. J Mol Biol. 2003 Feb 21; 326(3):679-90. PMID: 12581632.
    Citations: 8     Fields:    Translation:Cells
  72. Adelman K, La Porta A, Santangelo TJ, Lis JT, Roberts JW, Wang MD. Single molecule analysis of RNA polymerase elongation reveals uniform kinetic behavior. Proc Natl Acad Sci U S A. 2002 Oct 15; 99(21):13538-43. PMID: 12370445; PMCID: PMC129709.
    Citations: 85     Fields:    Translation:Cells
  73. Adelman K, Lis JT. How does Pol II overcome the nucleosome barrier? Mol Cell. 2002 Mar; 9(3):451-2. PMID: 11931751.
    Citations: 3     Fields:    Translation:Cells
  74. Urbauer JL, Simeonov MF, Urbauer RJ, Adelman K, Gilmore JM, Brody EN. Solution structure and stability of the anti-sigma factor AsiA: implications for novel functions. Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):1831-5. PMID: 11830637; PMCID: PMC122279.
    Citations: 15     Fields:    Translation:Cells
  75. Urbauer JL, Adelman K, Urbauer RJ, Simeonov MF, Gilmore JM, Zolkiewski M, Brody EN. Conserved regions 4.1 and 4.2 of sigma(70) constitute the recognition sites for the anti-sigma factor AsiA, and AsiA is a dimer free in solution. J Biol Chem. 2001 Nov 02; 276(44):41128-32. PMID: 11518715.
    Citations: 14     Fields:    Translation:Cells
  76. Adelman K, Salmon B, Baines JD. Herpes simplex virus DNA packaging sequences adopt novel structures that are specifically recognized by a component of the cleavage and packaging machinery. Proc Natl Acad Sci U S A. 2001 Mar 13; 98(6):3086-91. PMID: 11248036; PMCID: PMC30611.
    Citations: 58     Fields:    Translation:HumansCells
  77. Adelman K, Brody EN, Buckle M. Stimulation of bacteriophage T4 middle transcription by the T4 proteins MotA and AsiA occurs at two distinct steps in the transcription cycle. Proc Natl Acad Sci U S A. 1998 Dec 22; 95(26):15247-52. PMID: 9860954; PMCID: PMC28028.
    Citations: 11     Fields:    Translation:Cells
  78. Adelman K, Orsini G, Kolb A, Graziani L, Brody EN. The interaction between the AsiA protein of bacteriophage T4 and the sigma70 subunit of Escherichia coli RNA polymerase. J Biol Chem. 1997 Oct 24; 272(43):27435-43. PMID: 9341196.
    Citations: 21     Fields:    Translation:Cells
  79. Urbauer JL, Adelman K, Brody EN. Main-chain NMR assignments for AsiA. J Biomol NMR. 1997 Sep; 10(2):205-6. PMID: 9369017.
    Citations: 2     Fields:    Translation:Cells
  80. Yao W, Adelman K, Bruenn JA. In vitro selection of packaging sites in a double-stranded RNA virus. J Virol. 1997 Mar; 71(3):2157-62. PMID: 9032349; PMCID: PMC191321.
    Citations: 2     Fields:    Translation:AnimalsCells
  81. Ouhammouch M, Adelman K, Harvey SR, Orsini G, Brody EN. Bacteriophage T4 MotA and AsiA proteins suffice to direct Escherichia coli RNA polymerase to initiate transcription at T4 middle promoters. Proc Natl Acad Sci U S A. 1995 Feb 28; 92(5):1451-5. PMID: 7877999; PMCID: PMC42537.
    Citations: 32     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.