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Staci Bilbo, Ph.D.

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Overview
My research group focuses on the study of neuroimmune interactions in brain development, using pre-clinical models. We collaborate with clinical research groups to translate our findings to human populations. We are particularly interested in the role of immune molecules in both normal and disrupted brain development, based on evidence from human and animal studies that immune system dysfunction or inflammation may be critical in a number of neurodevelopmental disorders, including schizophrenia, cognitive and mood disorders, and autism. A particular focus is on the resident immune cells of the brain, microglia, including their development and function in response to early life inflammatory signals. I developed a model of neonatal bacterial infection during my post-doc and early years as an assistant professor that demonstrated that neonatal infection leads to lifelong vulnerability to cognitive disruption, via specific, enduring changes in microglial function (Bilbo et al., J Neurosci, 2005; Williamson et al., J Neurosci, 2011). Based on these results I have argued that the early life environment of an individual is especially critical in shaping the way that microglia and hence the brain develop, with significant consequences for brain and behavior throughout the remainder of the lifespan. I further hypothesized this model would provide a reference for the understanding of a potentially wide range of environmental factors that impact the developing immune system, such as social and environmental toxins, diet, drugs of abuse, and others, which thereby enduringly alters neuroendocrine function, including the risk of disorders such as autism. We now have strong evidence that this is the case. A greater understanding of the specific mechanisms underlying the role of the immune system in neural development will allow researchers and medical professionals to expand their current view of immune molecules, traditionally considered important only during sickness, to a broader role for these fascinating molecules in many basic physiological processes.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01ES025549 (BILBO, STACI D) Sep 30, 2016 - Aug 31, 2021
    NIH/NIEHS
    Environmental Toxins and Microglia-Synapse Interactions in Autism
    Role: Principal Investigator
  2. R01MH101183 (BILBO, STACI D) Jul 5, 2013 - Apr 30, 2018
    NIH/NIMH
    Sex Differences in Developing Microglia: Implications for Synaptic Pruning
    Role: Principal Investigator
  3. R01DA034185 (BILBO, STACI D) May 15, 2013 - Jan 31, 2018
    NIH/NIDA
    Neural-Glial Interactions and Opioid Abuse: Modulation by Early-Life Experience
    Role: Principal Investigator
  4. R01MH083698 (BILBO, STACI D) Jun 8, 2009 - May 31, 2012
    NIH/NIMH
    Early Life Infection, Neuroinflammation, and Memory
    Role: Principal Investigator
  5. R01DA025978 (BILBO, STACI D) Sep 30, 2008 - May 31, 2013
    NIH/NIDA
    Early Life Origins of Risk &Resilience to Drugs of Abuse: Role of Glial Priming
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Smith CJ, Bhanot A, Norman E, Mullett JE, Bilbo SD, McDougle CJ, Zürcher NR, Hooker JM. A Protocol for Sedation Free MRI and PET Imaging in Adults with Autism Spectrum Disorder. J Autism Dev Disord. 2019 Jul; 49(7):3036-3044. PMID: 31004246.
    Citations:    
  2. Smith CJ, Bilbo SD. Microglia Sculpt Sex Differences in Social Behavior. Neuron. 2019 Apr 17; 102(2):275-277. PMID: 30998897.
    Citations:    
  3. Liu X, Nemeth DP, McKim DB, Zhu L, DiSabato DJ, Berdysz O, Gorantla G, Oliver B, Witcher KG, Wang Y, Negray CE, Vegesna RS, Sheridan JF, Godbout JP, Robson MJ, Blakely RD, Popovich PG, Bilbo SD, Quan N. Cell-Type-Specific Interleukin 1 Receptor 1 Signaling in the Brain Regulates Distinct Neuroimmune Activities. Immunity. 2019 Mar 19; 50(3):764-766. PMID: 30893590.
    Citations:    
  4. Kopec AM, Smith CJ, Bilbo SD. Neuro-Immune Mechanisms Regulating Social Behavior: Dopamine as Mediator? Trends Neurosci. 2019 May; 42(5):337-348. PMID: 30890276.
    Citations:    
  5. Liu X, Nemeth DP, McKim DB, Zhu L, DiSabato DJ, Berdysz O, Gorantla G, Oliver B, Witcher KG, Wang Y, Negray CE, Vegesna RS, Sheridan JF, Godbout JP, Robson MJ, Blakely RD, Popovich PG, Bilbo SD, Quan N. Cell-Type-Specific Interleukin 1 Receptor 1 Signaling in the Brain Regulates Distinct Neuroimmune Activities. Immunity. 2019 Feb 19; 50(2):317-333.e6. PMID: 30683620.
    Citations:    Fields:    
  6. Missig G, Robbins JO, Mokler EL, McCullough KM, Bilbo SD, McDougle CJ, Carlezon WA. Sex-dependent neurobiological features of prenatal immune activation via TLR7. Mol Psychiatry. 2019 Jan 04. PMID: 30610201.
    Citations:    Fields:    
  7. Edlow AG, Glass RM, Smith CJ, Tran PK, James K, Bilbo S. Placental Macrophages: A Window Into Fetal Microglial Function in Maternal Obesity. Int J Dev Neurosci. 2018 Nov 20. PMID: 30465871.
    Citations:    
  8. Rivera PD, Hanamsagar R, Kan MJ, Tran PK, Stewart D, Jo YC, Gunn M, Bilbo SD. Removal of microglial-specific MyD88 signaling alters dentate gyrus doublecortin and enhances opioid addiction-like behaviors. Brain Behav Immun. 2019 Feb; 76:104-115. PMID: 30447281.
    Citations:    Fields:    
  9. Bordt EA, Smith CJ, Demarest TG, Bilbo SD, Kingsbury MA. Mitochondria, Oxytocin, and Vasopressin: Unfolding the Inflammatory Protein Response. Neurotox Res. 2018 Sep 27. PMID: 30259418.
    Citations:    Fields:    
  10. Kopec AM, Smith CJ, Ayre NR, Sweat SC, Bilbo SD. Microglial dopamine receptor elimination defines sex-specific nucleus accumbens development and social behavior in adolescent rats. Nat Commun. 2018 09 25; 9(1):3769. PMID: 30254300.
    Citations: 1     Fields:    Translation:AnimalsCells
  11. Kentner AC, Bilbo SD, Brown AS, Hsiao EY, McAllister AK, Meyer U, Pearce BD, Pletnikov MV, Yolken RH, Bauman MD. Maternal immune activation: reporting guidelines to improve the rigor, reproducibility, and transparency of the model. Neuropsychopharmacology. 2019 01; 44(2):245-258. PMID: 30188509.
    Citations:    Fields:    
  12. Bilbo SD. The diverse culinary habits of microglia. Nat Neurosci. 2018 08; 21(8):1023-1025. PMID: 30038281.
    Citations:    Fields:    
  13. Kopec AM, Fiorentino MR, Bilbo SD. Gut-immune-brain dysfunction in Autism: Importance of sex. Brain Res. 2018 08 15; 1693(Pt B):214-217. PMID: 29360468.
    Citations: 2     Fields:    
  14. Dozmorov MG, Bilbo SD, Kollins SH, Zucker N, Do EK, Schechter JC, Zhang JJ, Murphy SK, Hoyo C, Fuemmeler BF. Associations between maternal cytokine levels during gestation and measures of child cognitive abilities and executive functioning. Brain Behav Immun. 2018 05; 70:390-397. PMID: 29588230.
    Citations:    Fields:    
  15. Hanamsagar R, Alter MD, Block CS, Sullivan H, Bolton JL, Bilbo SD. Generation of a microglial developmental index in mice and in humans reveals a sex difference in maturation and immune reactivity. Glia. 2018 02; 66(2):460. PMID: 29230901.
    Citations:    Fields:    
  16. Hanamsagar R, Bilbo SD. Environment matters: microglia function and dysfunction in a changing world. Curr Opin Neurobiol. 2017 12; 47:146-155. PMID: 29096243.
    Citations: 1     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  17. Bilbo S, Stevens B. Microglia: The Brain's First Responders. Cerebrum. 2017 Nov-Dec; 2017. PMID: 30210663.
    Citations:    
  18. Bolton JL, Wiley MG, Ryan B, Truong S, Strait M, Baker DC, Yang NY, Ilkayeva O, O'Connell TM, Wroth SW, Sánchez CL, Swamy G, Newgard C, Kuhn C, Bilbo SD, Simmons LA. Perinatal western-type diet and associated gestational weight gain alter postpartum maternal mood. Brain Behav. 2017 10; 7(10):e00828. PMID: 29075574.
    Citations:    Fields:    Translation:HumansAnimals
  19. Bilbo SD, Block CL, Bolton JL, Hanamsagar R, Tran PK. Beyond infection - Maternal immune activation by environmental factors, microglial development, and relevance for autism spectrum disorders. Exp Neurol. 2018 01; 299(Pt A):241-251. PMID: 28698032.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  20. McCullough LE, Miller EE, Calderwood LE, Shivappa N, Steck SE, Forman MR, A Mendez M, Maguire R, Fuemmeler BF, Kollins SH, D Bilbo S, Huang Z, Murtha AP, Murphy SK, Hébert JR, Hoyo C. Maternal inflammatory diet and adverse pregnancy outcomes: Circulating cytokines and genomic imprinting as potential regulators? Epigenetics. 2017 08; 12(8):688-697. PMID: 28678596.
    Citations: 2     Fields:    Translation:HumansCells
  21. Hanamsagar R, Alter MD, Block CS, Sullivan H, Bolton JL, Bilbo SD. Generation of a microglial developmental index in mice and in humans reveals a sex difference in maturation and immune reactivity. Glia. 2017 09; 65(9):1504-1520. PMID: 28618077.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  22. Bolton JL, Marinero S, Hassanzadeh T, Natesan D, Le D, Belliveau C, Mason SN, Auten RL, Bilbo SD. Gestational Exposure to Air Pollution Alters Cortical Volume, Microglial Morphology, and Microglia-Neuron Interactions in a Sex-Specific Manner. Front Synaptic Neurosci. 2017; 9:10. PMID: 28620294.
    Citations: 6     
  23. Bilbo SD. Sex differences in microglial appetites during development: Inferences and implications. Brain Behav Immun. 2017 08; 64:9-10. PMID: 28506692.
    Citations:    Fields:    Translation:HumansCells
  24. Lacagnina MJ, Kopec AM, Cox SS, Hanamsagar R, Wells C, Slade S, Grace PM, Watkins LR, Levin ED, Bilbo SD. Opioid Self-Administration is Attenuated by Early-Life Experience and Gene Therapy for Anti-Inflammatory IL-10 in the Nucleus Accumbens of Male Rats. Neuropsychopharmacology. 2017 Oct; 42(11):2128-2140. PMID: 28436446.
    Citations: 1     Fields:    Translation:AnimalsCells
  25. Parker W, Hornik CD, Bilbo S, Holzknecht ZE, Gentry L, Rao R, Lin SS, Herbert MR, Nevison CD. The role of oxidative stress, inflammation and acetaminophen exposure from birth to early childhood in the induction of autism. J Int Med Res. 2017 Apr; 45(2):407-438. PMID: 28415925.
    Citations: 4     Fields:    Translation:Humans
  26. Kopec AM, Rivera PD, Lacagnina MJ, Hanamsagar R, Bilbo SD. Optimized solubilization of TRIzol-precipitated protein permits Western blotting analysis to maximize data available from brain tissue. J Neurosci Methods. 2017 03 15; 280:64-76. PMID: 28192129.
    Citations: 2     Fields:    Translation:AnimalsCells
  27. Lacagnina MJ, Rivera PD, Bilbo SD. Glial and Neuroimmune Mechanisms as Critical Modulators of Drug Use and Abuse. Neuropsychopharmacology. 2017 01; 42(1):156-177. PMID: 27402494.
    Citations: 15     Fields:    Translation:HumansCells
  28. Kraft AD, Aschner M, Cory-Slechta DA, Bilbo SD, Caudle WM, Makris SL. Unmasking silent neurotoxicity following developmental exposure to environmental toxicants. Neurotoxicol Teratol. 2016 May-Jun; 55:38-44. PMID: 27049787.
    Citations: 2     Fields:    Translation:HumansAnimalsPHPublic Health
  29. Posillico CK, Terasaki LS, Bilbo SD, Schwarz JM. Examination of sex and minocycline treatment on acute morphine-induced analgesia and inflammatory gene expression along the pain pathway in Sprague-Dawley rats. Biol Sex Differ. 2015; 6:33. PMID: 26693004.
    Citations: 5     Fields:    
  30. Hanamsagar R, Bilbo SD. Sex differences in neurodevelopmental and neurodegenerative disorders: Focus on microglial function and neuroinflammation during development. J Steroid Biochem Mol Biol. 2016 06; 160:127-33. PMID: 26435451.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  31. Williamson LL, McKenney EA, Holzknecht ZE, Belliveau C, Rawls JF, Poulton S, Parker W, Bilbo SD. Got worms? Perinatal exposure to helminths prevents persistent immune sensitization and cognitive dysfunction induced by early-life infection. Brain Behav Immun. 2016 Jan; 51:14-28. PMID: 26162711.
    Citations: 14     Fields:    Translation:AnimalsCells
  32. Bilbo SD, Nevison CD, Parker W. A model for the induction of autism in the ecosystem of the human body: the anatomy of a modern pandemic? Microb Ecol Health Dis. 2015; 26:26253. PMID: 25634608.
    Citations: 5     
  33. McKenney EA, Williamson L, Yoder AD, Rawls JF, Bilbo SD, Parker W. Alteration of the rat cecal microbiome during colonization with the helminth Hymenolepis diminuta. Gut Microbes. 2015; 6(3):182-93. PMID: 25942385.
    Citations: 9     Fields:    Translation:AnimalsCells
  34. Bolton JL, Bilbo SD. Developmental programming of brain and behavior by perinatal diet: focus on inflammatory mechanisms. Dialogues Clin Neurosci. 2014 Sep; 16(3):307-20. PMID: 25364282.
    Citations: 17     Fields:    Translation:HumansAnimals
  35. Williamson LL, Bilbo SD. Neonatal infection modulates behavioral flexibility and hippocampal activation on a Morris Water Maze task. Physiol Behav. 2014 Apr 22; 129:152-9. PMID: 24576680.
    Citations: 3     Fields:    Translation:Animals
  36. Bolton JL, Auten RL, Bilbo SD. Prenatal air pollution exposure induces sexually dimorphic fetal programming of metabolic and neuroinflammatory outcomes in adult offspring. Brain Behav Immun. 2014 Mar; 37:30-44. PMID: 24184474.
    Citations: 15     Fields:    Translation:AnimalsPHPublic Health
  37. Lieblein-Boff JC, McKim DB, Shea DT, Wei P, Deng Z, Sawicki C, Quan N, Bilbo SD, Bailey MT, McTigue DM, Godbout JP. Neonatal E. coli infection causes neuro-behavioral deficits associated with hypomyelination and neuronal sequestration of iron. J Neurosci. 2013 Oct 09; 33(41):16334-45. PMID: 24107964.
    Citations: 14     Fields:    Translation:AnimalsCells
  38. Bolton JL, Huff NC, Smith SH, Mason SN, Foster WM, Auten RL, Bilbo SD. Maternal stress and effects of prenatal air pollution on offspring mental health outcomes in mice. Environ Health Perspect. 2013 Sep; 121(9):1075-82. PMID: 23823752.
    Citations: 25     Fields:    Translation:AnimalsCells
  39. Schwarz JM, Smith SH, Bilbo SD. FACS analysis of neuronal-glial interactions in the nucleus accumbens following morphine administration. Psychopharmacology (Berl). 2013 Dec; 230(4):525-35. PMID: 23793269.
    Citations: 15     Fields:    Translation:AnimalsCells
  40. Bilbo SD. Frank A. Beach award: programming of neuroendocrine function by early-life experience: a critical role for the immune system. Horm Behav. 2013 May; 63(5):684-91. PMID: 23474365.
    Citations: 12     Fields:    Translation:AnimalsCells
  41. Williamson LL, Bilbo SD. Chemokines and the hippocampus: a new perspective on hippocampal plasticity and vulnerability. Brain Behav Immun. 2013 May; 30:186-94. PMID: 23376170.
    Citations: 29     Fields:    Translation:AnimalsCells
  42. Schwarz JM, Bilbo SD. Adolescent morphine exposure affects long-term microglial function and later-life relapse liability in a model of addiction. J Neurosci. 2013 Jan 16; 33(3):961-71. PMID: 23325235.
    Citations: 28     Fields:    Translation:AnimalsCells
  43. Bilbo SD, Schwarz JM. The immune system and developmental programming of brain and behavior. Front Neuroendocrinol. 2012 Aug; 33(3):267-86. PMID: 22982535.
    Citations: 89     Fields:    Translation:AnimalsCells
  44. Block ML, Elder A, Auten RL, Bilbo SD, Chen H, Chen JC, Cory-Slechta DA, Costa D, Diaz-Sanchez D, Dorman DC, Gold DR, Gray K, Jeng HA, Kaufman JD, Kleinman MT, Kirshner A, Lawler C, Miller DS, Nadadur SS, Ritz B, Semmens EO, Tonelli LH, Veronesi B, Wright RO, Wright RJ. The outdoor air pollution and brain health workshop. Neurotoxicology. 2012 Oct; 33(5):972-84. PMID: 22981845.
    Citations: 70     Fields:    Translation:HumansPHPublic Health
  45. Bolton JL, Smith SH, Huff NC, Gilmour MI, Foster WM, Auten RL, Bilbo SD. Prenatal air pollution exposure induces neuroinflammation and predisposes offspring to weight gain in adulthood in a sex-specific manner. FASEB J. 2012 Nov; 26(11):4743-54. PMID: 22815382.
    Citations: 47     Fields:    Translation:AnimalsCells
  46. Bilbo SD, Klein SL. Special Issue: the neuroendocrine-immune axis in health and disease. Horm Behav. 2012 Aug; 62(3):187-90. PMID: 22789778.
    Citations: 3     Fields:    Translation:HumansAnimals
  47. Bilbo SD, Jones JP, Parker W. Is autism a member of a family of diseases resulting from genetic/cultural mismatches? Implications for treatment and prevention. Autism Res Treat. 2012; 2012:910946. PMID: 22928103.
    Citations: 4     
  48. Schwarz JM, Bilbo SD. Sex, glia, and development: interactions in health and disease. Horm Behav. 2012 Aug; 62(3):243-53. PMID: 22387107.
    Citations: 48     Fields:    Translation:AnimalsCells
  49. Schwarz JM, Sholar PW, Bilbo SD. Sex differences in microglial colonization of the developing rat brain. J Neurochem. 2012 Mar; 120(6):948-63. PMID: 22182318.
    Citations: 89     Fields:    Translation:AnimalsCells
  50. Williamson LL, Chao A, Bilbo SD. Environmental enrichment alters glial antigen expression and neuroimmune function in the adult rat hippocampus. Brain Behav Immun. 2012 Mar; 26(3):500-10. PMID: 22281279.
    Citations: 30     Fields:    Translation:AnimalsCells
  51. Schwarz JM, Hutchinson MR, Bilbo SD. Early-life experience decreases drug-induced reinstatement of morphine CPP in adulthood via microglial-specific epigenetic programming of anti-inflammatory IL-10 expression. J Neurosci. 2011 Dec 07; 31(49):17835-47. PMID: 22159099.
    Citations: 55     Fields:    Translation:AnimalsCells
  52. Williamson LL, Sholar PW, Mistry RS, Smith SH, Bilbo SD. Microglia and memory: modulation by early-life infection. J Neurosci. 2011 Oct 26; 31(43):15511-21. PMID: 22031897.
    Citations: 65     Fields:    Translation:AnimalsCells
  53. Bilbo SD, Smith SH, Schwarz JM. A lifespan approach to neuroinflammatory and cognitive disorders: a critical role for glia. J Neuroimmune Pharmacol. 2012 Mar; 7(1):24-41. PMID: 21822589.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  54. Bilbo SD, Wray GA, Perkins SE, Parker W. Reconstitution of the human biome as the most reasonable solution for epidemics of allergic and autoimmune diseases. Med Hypotheses. 2011 Oct; 77(4):494-504. PMID: 21741180.
    Citations: 19     Fields:    Translation:HumansAnimals
  55. Schwarz JM, Bilbo SD. LPS elicits a much larger and broader inflammatory response than Escherichia coli infection within the hippocampus of neonatal rats. Neurosci Lett. 2011 Jun 22; 497(2):110-5. PMID: 21536105.
    Citations: 15     Fields:    Translation:AnimalsCells
  56. Bilbo SD. How cytokines leave their mark: the role of the placenta in developmental programming of brain and behavior. Brain Behav Immun. 2011 May; 25(4):602-3. PMID: 21296146.
    Citations: 1     Fields:    Translation:HumansAnimalsPHPublic Health
  57. Bilbo SD. Early-life infection is a vulnerability factor for aging-related glial alterations and cognitive decline. Neurobiol Learn Mem. 2010 Jul; 94(1):57-64. PMID: 20388544.
    Citations: 31     Fields:    Translation:AnimalsCells
  58. Bland ST, Beckley JT, Watkins LR, Maier SF, Bilbo SD. Neonatal Escherichia coli infection alters glial, cytokine, and neuronal gene expression in response to acute amphetamine in adolescent rats. Neurosci Lett. 2010 Apr 19; 474(1):52-7. PMID: 20223277.
    Citations: 9     Fields:    Translation:AnimalsCells
  59. Bilbo SD, Tsang V. Enduring consequences of maternal obesity for brain inflammation and behavior of offspring. FASEB J. 2010 Jun; 24(6):2104-15. PMID: 20124437.
    Citations: 91     Fields:    Translation:Animals
  60. Bland ST, Beckley JT, Young S, Tsang V, Watkins LR, Maier SF, Bilbo SD. Enduring consequences of early-life infection on glial and neural cell genesis within cognitive regions of the brain. Brain Behav Immun. 2010 Mar; 24(3):329-38. PMID: 19782746.
    Citations: 42     Fields:    Translation:AnimalsCells
  61. Bilbo SD, Schwarz JM. Early-life programming of later-life brain and behavior: a critical role for the immune system. Front Behav Neurosci. 2009; 3:14. PMID: 19738918.
    Citations: 148     
  62. Bilbo SD, Wieseler JL, Barrientos RM, Tsang V, Watkins LR, Maier SF. Neonatal bacterial infection alters fever to live and simulated infections in adulthood. Psychoneuroendocrinology. 2010 Apr; 35(3):369-81. PMID: 19682802.
    Citations: 11     Fields:    Translation:AnimalsCells
  63. Bilbo SD, Yirmiya R, Amat J, Paul ED, Watkins LR, Maier SF. Bacterial infection early in life protects against stressor-induced depressive-like symptoms in adult rats. Psychoneuroendocrinology. 2008 Apr; 33(3):261-9. PMID: 18164556.
    Citations: 21     Fields:    Translation:Animals
  64. Bilbo SD, Barrientos RM, Eads AS, Northcutt A, Watkins LR, Rudy JW, Maier SF. Early-life infection leads to altered BDNF and IL-1beta mRNA expression in rat hippocampus following learning in adulthood. Brain Behav Immun. 2008 May; 22(4):451-5. PMID: 17997277.
    Citations: 35     Fields:    Translation:Animals
  65. Zala SM, Chan BK, Bilbo SD, Potts WK, Nelson RJ, Penn DJ. Genetic resistance to infection influences a male's sexual attractiveness and modulation of testosterone. Brain Behav Immun. 2008 Mar; 22(3):381-7. PMID: 17945466.
    Citations: 4     Fields:    Translation:Animals
  66. Bowers SL, Bilbo SD, Dhabhar FS, Nelson RJ. Stressor-specific alterations in corticosterone and immune responses in mice. Brain Behav Immun. 2008 Jan; 22(1):105-13. PMID: 17890050.
    Citations: 44     Fields:    Translation:AnimalsCells
  67. Bilbo SD, Newsum NJ, Sprunger DB, Watkins LR, Rudy JW, Maier SF. Differential effects of neonatal handling on early life infection-induced alterations in cognition in adulthood. Brain Behav Immun. 2007 Mar; 21(3):332-42. PMID: 17126527.
    Citations: 29     Fields:    Translation:AnimalsCells
  68. Bilbo SD, Rudy JW, Watkins LR, Maier SF. A behavioural characterization of neonatal infection-facilitated memory impairment in adult rats. Behav Brain Res. 2006 Apr 25; 169(1):39-47. PMID: 16413067.
    Citations: 42     Fields:    Translation:Animals
  69. Neigh GN, Glasper ER, Bilbo SD, Traystman RJ, Courtney DeVries A. Cardiac arrest/cardiopulmonary resuscitation augments cell-mediated immune function and transiently suppresses humoral immune function. J Cereb Blood Flow Metab. 2005 Nov; 25(11):1424-32. PMID: 15874972.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  70. Bilbo SD, Biedenkapp JC, Der-Avakian A, Watkins LR, Rudy JW, Maier SF. Neonatal infection-induced memory impairment after lipopolysaccharide in adulthood is prevented via caspase-1 inhibition. J Neurosci. 2005 Aug 31; 25(35):8000-9. PMID: 16135757.
    Citations: 62     Fields:    Translation:Animals
  71. Bilbo SD, Levkoff LH, Mahoney JH, Watkins LR, Rudy JW, Maier SF. Neonatal infection induces memory impairments following an immune challenge in adulthood. Behav Neurosci. 2005 Feb; 119(1):293-301. PMID: 15727533.
    Citations: 54     Fields:    Translation:AnimalsCells
  72. Prendergast BJ, Bilbo SD, Nelson RJ. Short day lengths enhance skin immune responses in gonadectomised Siberian hamsters. J Neuroendocrinol. 2005 Jan; 17(1):18-21. PMID: 15720471.
    Citations: 7     Fields:    Translation:Animals
  73. Neigh GN, Bilbo SD, Hotchkiss AK, Nelson RJ. Exogenous pyruvate prevents stress-evoked suppression of mitogen-stimulated proliferation. Brain Behav Immun. 2004 Sep; 18(5):425-33. PMID: 15265535.
    Citations: 1     Fields:    Translation:AnimalsCells
  74. Prendergast BJ, Bilbo SD, Dhabhar FS, Nelson RJ. Effects of photoperiod history on immune responses to intermediate day lengths in Siberian hamsters (Phodopus sungorus). J Neuroimmunol. 2004 Apr; 149(1-2):31-9. PMID: 15020062.
    Citations: 14     Fields:    Translation:AnimalsCellsPHPublic Health
  75. Bilbo SD, Nelson RJ. Sex differences in photoperiodic and stress-induced enhancement of immune function in Siberian hamsters. Brain Behav Immun. 2003 Dec; 17(6):462-72. PMID: 14583238.
    Citations: 12     Fields:    Translation:Animals
  76. Prendergast BJ, Hotchkiss AK, Bilbo SD, Nelson RJ. Peripubertal immune challenges attenuate reproductive development in male Siberian hamsters (Phodopus sungorus). Biol Reprod. 2004 Mar; 70(3):813-20. PMID: 14627552.
    Citations: 9     Fields:    Translation:Animals
  77. Bilbo SD, Nelson RJ. Photoperiod influences the effects of exercise and food restriction on an antigen-specific immune response in Siberian hamsters. Endocrinology. 2004 Feb; 145(2):556-64. PMID: 14605007.
    Citations: 1     Fields:    Translation:Animals
  78. Bilbo SD, Dhabhar FS, Viswanathan K, Saul A, Nelson RJ. Photoperiod affects the expression of sex and species differences in leukocyte number and leukocyte trafficking in congeneric hamsters. Psychoneuroendocrinology. 2003 Nov; 28(8):1027-43. PMID: 14529706.
    Citations: 2     Fields:    Translation:AnimalsCells
  79. Bilbo SD, Quan N, Prendergast BJ, Bowers SL, Nelson RJ. Photoperiod alters the time course of brain cyclooxygenase-2 expression in Siberian hamsters. J Neuroendocrinol. 2003 Oct; 15(10):958-64. PMID: 12969240.
    Citations: 5     Fields:    Translation:Animals
  80. Prendergast BJ, Bilbo SD, Nelson RJ. Photoperiod controls the induction, retention, and retrieval of antigen-specific immunological memory. Am J Physiol Regul Integr Comp Physiol. 2004 Jan; 286(1):R54-60. PMID: 12958060.
    Citations: 4     Fields:    Translation:AnimalsPHPublic Health
  81. Bilbo SD, Hotchkiss AK, Chiavegatto S, Nelson RJ. Blunted stress responses in delayed type hypersensitivity in mice lacking the neuronal isoform of nitric oxide synthase. J Neuroimmunol. 2003 Jul; 140(1-2):41-8. PMID: 12864970.
    Citations: 5     Fields:    Translation:AnimalsCells
  82. Prendergast BJ, Hotchkiss AK, Bilbo SD, Kinsey SG, Nelson RJ. Photoperiodic adjustments in immune function protect Siberian hamsters from lethal endotoxemia. J Biol Rhythms. 2003 Feb; 18(1):51-62. PMID: 12568244.
    Citations: 14     Fields:    Translation:AnimalsCells
  83. Bilbo SD, Nelson RJ. Melatonin regulates energy balance and attenuates fever in Siberian hamsters. Endocrinology. 2002 Jul; 143(7):2527-33. PMID: 12072384.
    Citations: 15     Fields:    Translation:Animals
  84. Bilbo SD, Dhabhar FS, Viswanathan K, Saul A, Yellon SM, Nelson RJ. Short day lengths augment stress-induced leukocyte trafficking and stress-induced enhancement of skin immune function. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):4067-72. PMID: 11904451.
    Citations: 27     Fields:    Translation:AnimalsCells
  85. Bilbo SD, Drazen DL, Quan N, He L, Nelson RJ. Short day lengths attenuate the symptoms of infection in Siberian hamsters. Proc Biol Sci. 2002 Mar 07; 269(1490):447-54. PMID: 11886635.
    Citations: 26     Fields:    Translation:Animals
  86. Drazen DL, Bilu D, Bilbo SD, Nelson RJ. Melatonin enhancement of splenocyte proliferation is attenuated by luzindole, a melatonin receptor antagonist. Am J Physiol Regul Integr Comp Physiol. 2001 May; 280(5):R1476-82. PMID: 11294771.
    Citations: 18     Fields:    Translation:AnimalsCells
  87. Bilbo SD, Nelson RJ. Behavioral phenotyping of transgenic and knockout animals: a cautionary tale. Lab Anim (NY). 2001 Jan; 30(1):24-9. PMID: 11385723.
    Citations: 3     Fields:    Translation:Animals
  88. Bilbo SD, Nelson RJ. Sex steroid hormones enhance immune function in male and female Siberian hamsters. Am J Physiol Regul Integr Comp Physiol. 2001 Jan; 280(1):R207-13. PMID: 11124153.
    Citations: 12     Fields:    Translation:AnimalsCells
  89. Bilbo SD, Day LB, Wilczynski W. Anticholinergic effects in frogs in a Morris water maze analog. Physiol Behav. 2000 May; 69(3):351-7. PMID: 10869602.
    Citations: 1     Fields:    Translation:Animals
  90. Bilbo SD, Klein SL, DeVries AC, Nelson RJ. Lipopolysaccharide facilitates partner preference behaviors in female prairie voles. Physiol Behav. 1999 Dec 1-15; 68(1-2):151-6. PMID: 10627074.
    Citations: 4     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.