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Jason Matthew Schenkel, Ph.D.

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  1. F30DK100159 (SCHENKEL, JASON M) Aug 1, 2013 - Jul 31, 2016
    Trafficking &role of effector memory CD8T cell subsets in small intestine
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Newman JH, Chesson CB, Herzog NL, Bommareddy PK, Aspromonte SM, Pepe R, Estupinian R, Aboelatta MM, Buddhadev S, Tarabichi S, Lee M, Li S, Medina DJ, Giurini EF, Gupta KH, Guevara-Aleman G, Rossi M, Nowicki C, Abed A, Goldufsky JW, Broucek JR, Redondo RE, Rotter D, Jhawar SR, Wang SJ, Kohlhapp FJ, Kaufman HL, Thomas PG, Gupta V, Kuzel TM, Reiser J, Paras J, Kane MP, Singer EA, Malhotra J, Denzin LK, Sant'Angelo DB, Rabson AB, Lee LY, Lasfar A, Langenfeld J, Schenkel JM, Fidler MJ, Ruiz ES, Marzo AL, Rudra JS, Silk AW, Zloza A. Intratumoral injection of the seasonal flu shot converts immunologically cold tumors to hot and serves as an immunotherapy for cancer. Proc Natl Acad Sci U S A. 2020 01 14; 117(2):1119-1128. PMID: 31888983.
  2. Ng SR, Rideout WM, Akama-Garren EH, Bhutkar A, Mercer KL, Schenkel JM, Bronson RT, Jacks T. CRISPR-mediated modeling and functional validation of candidate tumor suppressor genes in small cell lung cancer. Proc Natl Acad Sci U S A. 2020 01 07; 117(1):513-521. PMID: 31871154.
  3. Li A, Herbst RH, Canner D, Schenkel JM, Smith OC, Kim JY, Hillman M, Bhutkar A, Cuoco MS, Rappazzo CG, Rogers P, Dang C, Jerby-Arnon L, Rozenblatt-Rosen O, Cong L, Birnbaum M, Regev A, Jacks T. IL-33 Signaling Alters Regulatory T Cell Diversity in Support of Tumor Development. Cell Rep. 2019 12 03; 29(10):2998-3008.e8. PMID: 31801068.
  4. Schenkel JM, Hergott CB, Dudley G, Drew M, Charest K, Dorfman DM. Use of a Blast Dominance-Hematogone Index for the Flow Cytometric Evaluation of Myelodysplastic Syndrome (MDS). Am J Clin Pathol. 2019 05 03; 151(6):584-592. PMID: 30854558.
  5. Beura LK, Fares-Frederickson NJ, Steinert EM, Scott MC, Thompson EA, Fraser KA, Schenkel JM, Vezys V, Masopust D. CD4+ resident memory T cells dominate immunosurveillance and orchestrate local recall responses. J Exp Med. 2019 05 06; 216(5):1214-1229. PMID: 30923043.
  6. Gansner JM, Rahmani M, Jonsson AH, Fortin BM, Brimah I, Ellis M, Smeland-Wagman R, Li ZJ, Schenkel JM, Brenner MB, Yefidoff-Freedman R, Sloan SR, Berliner N, Issa NC, Baden LR, Longo DL, Wesemann DR, Neuberg D, Rao DA, Kaufman RM. Plateletpheresis-associated lymphopenia in frequent platelet donors. Blood. 2019 02 07; 133(6):605-614. PMID: 30429159.
    Citations:    Fields:    
  7. Romaguera JE, Lee HJ, Tarapore R, Prabhu V, Allen J, Schalop L, Zloza A, Ok CY, Sadimin ET, Schenkel J, Badillo M, Wang M. Integrated stress response and immune cell infiltration in an ibrutinib-refractory mantle cell lymphoma patient following ONC201 treatment. Br J Haematol. 2019 04; 185(1):133-136. PMID: 29740811.
    Citations:    Fields:    
  8. Mehnert JM, Silk AW, Lee JH, Dudek L, Jeong BS, Li J, Schenkel JM, Sadimin E, Kane M, Lin H, Shih WJ, Zloza A, Chen S, Goydos JS. A phase II trial of riluzole, an antagonist of metabotropic glutamate receptor 1 (GRM1) signaling, in patients with advanced melanoma. Pigment Cell Melanoma Res. 2018 07; 31(4):534-540. PMID: 29453787.
    Citations: 1     Fields:    
  9. Beura LK, Wijeyesinghe S, Thompson EA, Macchietto MG, Rosato PC, Pierson MJ, Schenkel JM, Mitchell JS, Vezys V, Fife BT, Shen S, Masopust D. T Cells in Nonlymphoid Tissues Give Rise to Lymph-Node-Resident Memory T Cells. Immunity. 2018 02 20; 48(2):327-338.e5. PMID: 29466758.
    Citations: 3     Fields:    Translation:AnimalsCells
  10. Beura LK, Mitchell JS, Thompson EA, Schenkel JM, Mohammed J, Wijeyesinghe S, Fonseca R, Burbach BJ, Hickman HD, Vezys V, Fife BT, Masopust D. Intravital mucosal imaging of CD8+ resident memory T cells shows tissue-autonomous recall responses that amplify secondary memory. Nat Immunol. 2018 02; 19(2):173-182. PMID: 29311694.
    Citations: 6     Fields:    
  11. Jhawar SR, Thandoni A, Bommareddy PK, Hassan S, Kohlhapp FJ, Goyal S, Schenkel JM, Silk AW, Zloza A. Oncolytic Viruses-Natural and Genetically Engineered Cancer Immunotherapies. Front Oncol. 2017; 7:202. PMID: 28955655.
    Citations: 4     
  12. Huang AC, Postow MA, Orlowski RJ, Mick R, Bengsch B, Manne S, Xu W, Harmon S, Giles JR, Wenz B, Adamow M, Kuk D, Panageas KS, Carrera C, Wong P, Quagliarello F, Wubbenhorst B, D'Andrea K, Pauken KE, Herati RS, Staupe RP, Schenkel JM, McGettigan S, Kothari S, George SM, Vonderheide RH, Amaravadi RK, Karakousis GC, Schuchter LM, Xu X, Nathanson KL, Wolchok JD, Gangadhar TC, Wherry EJ. T-cell invigoration to tumour burden ratio associated with anti-PD-1 response. Nature. 2017 05 04; 545(7652):60-65. PMID: 28397821.
    Citations: 65     Fields:    Translation:HumansCellsCTClinical Trials
  13. Pauken KE, Sammons MA, Odorizzi PM, Manne S, Godec J, Khan O, Drake AM, Chen Z, Sen DR, Kurachi M, Barnitz RA, Bartman C, Bengsch B, Huang AC, Schenkel JM, Vahedi G, Haining WN, Berger SL, Wherry EJ. Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade. Science. 2016 12 02; 354(6316):1160-1165. PMID: 27789795.
    Citations: 65     Fields:    Translation:AnimalsCells
  14. Kohlhapp FJ, Huelsmann EJ, Lacek AT, Schenkel JM, Lusciks J, Broucek JR, Goldufsky JW, Hughes T, Zayas JP, Dolubizno H, Sowell RT, Kühner R, Burd S, Kubasiak JC, Nabatiyan A, Marshall S, Bommareddy PK, Li S, Newman JH, Monken CE, Shafikhani SH, Marzo AL, Guevara-Patino JA, Lasfar A, Thomas PG, Lattime EC, Kaufman HL, Zloza A. Non-oncogenic Acute Viral Infections Disrupt Anti-cancer Responses and Lead to Accelerated Cancer-Specific Host Death. Cell Rep. 2016 10 18; 17(4):957-965. PMID: 27760326.
    Citations: 6     Fields:    Translation:AnimalsCells
  15. Manlove LS, Schenkel JM, Manlove KR, Pauken KE, Williams RT, Vezys V, Farrar MA. Heterologous Vaccination and Checkpoint Blockade Synergize To Induce Antileukemia Immunity. J Immunol. 2016 06 01; 196(11):4793-804. PMID: 27183622.
    Citations: 1     Fields:    Translation:AnimalsPHPublic Health
  16. Beura LK, Hamilton SE, Bi K, Schenkel JM, Odumade OA, Casey KA, Thompson EA, Fraser KA, Rosato PC, Filali-Mouhim A, Sekaly RP, Jenkins MK, Vezys V, Haining WN, Jameson SC, Masopust D. Normalizing the environment recapitulates adult human immune traits in laboratory mice. Nature. 2016 Apr 28; 532(7600):512-6. PMID: 27096360.
    Citations: 132     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  17. Schenkel JM, Fraser KA, Casey KA, Beura LK, Pauken KE, Vezys V, Masopust D. IL-15-Independent Maintenance of Tissue-Resident and Boosted Effector Memory CD8 T Cells. J Immunol. 2016 05 01; 196(9):3920-6. PMID: 27001957.
    Citations: 17     Fields:    Translation:AnimalsCells
  18. Hondowicz BD, An D, Schenkel JM, Kim KS, Steach HR, Krishnamurty AT, Keitany GJ, Garza EN, Fraser KA, Moon JJ, Altemeier WA, Masopust D, Pepper M. Interleukin-2-Dependent Allergen-Specific Tissue-Resident Memory Cells Drive Asthma. Immunity. 2016 Jan 19; 44(1):155-166. PMID: 26750312.
    Citations: 29     Fields:    Translation:AnimalsCells
  19. Kohlhapp FJ, Broucek JR, Hughes T, Huelsmann EJ, Lusciks J, Zayas JP, Dolubizno H, Fleetwood VA, Grin A, Hill GE, Poshepny JL, Nabatiyan A, Ruby CE, Snook JD, Rudra JS, Schenkel JM, Masopust D, Zloza A, Kaufman HL. NK cells and CD8+ T cells cooperate to improve therapeutic responses in melanoma treated with interleukin-2 (IL-2) and CTLA-4 blockade. J Immunother Cancer. 2015; 3:18. PMID: 25992289.
    Citations: 10     Fields:    
  20. Steinert EM, Schenkel JM, Fraser KA, Beura LK, Manlove LS, Igyártó BZ, Southern PJ, Masopust D. Quantifying Memory CD8 T Cells Reveals Regionalization of Immunosurveillance. Cell. 2015 May 07; 161(4):737-49. PMID: 25957682.
    Citations: 114     Fields:    Translation:AnimalsCells
  21. Pauken KE, Nelson CE, Martinov T, Spanier JA, Heffernan JR, Sahli NL, Quarnstrom CF, Osum KC, Schenkel JM, Jenkins MK, Blazar BR, Vezys V, Fife BT. Cutting edge: identification of autoreactive CD4+ and CD8+ T cell subsets resistant to PD-1 pathway blockade. J Immunol. 2015 Apr 15; 194(8):3551-3555. PMID: 25769925.
    Citations: 8     Fields:    Translation:AnimalsCells
  22. Schenkel JM, Masopust D. Tissue-resident memory T cells. Immunity. 2014 Dec 18; 41(6):886-97. PMID: 25526304.
    Citations: 143     Fields:    Translation:HumansAnimalsCells
  23. Beura LK, Anderson KG, Schenkel JM, Locquiao JJ, Fraser KA, Vezys V, Pepper M, Masopust D. Lymphocytic choriomeningitis virus persistence promotes effector-like memory differentiation and enhances mucosal T cell distribution. J Leukoc Biol. 2015 Feb; 97(2):217-25. PMID: 25395301.
    Citations: 16     Fields:    Translation:AnimalsCells
  24. Schenkel JM, Fraser KA, Beura LK, Pauken KE, Vezys V, Masopust D. T cell memory. Resident memory CD8 T cells trigger protective innate and adaptive immune responses. Science. 2014 Oct 03; 346(6205):98-101. PMID: 25170049.
    Citations: 128     Fields:    Translation:AnimalsCells
  25. Zloza A, Kim DW, Broucek J, Schenkel JM, Kaufman HL. High-dose IL-2 induces rapid albumin uptake by endothelial cells through Src-dependent caveolae-mediated endocytosis. J Interferon Cytokine Res. 2014 Nov; 34(11):915-9. PMID: 24963699.
    Citations: 3     Fields:    Translation:HumansCells
  26. Kim DW, Zloza A, Broucek J, Schenkel JM, Ruby C, Samaha G, Kaufman HL. Interleukin-2 alters distribution of CD144 (VE-cadherin) in endothelial cells. J Transl Med. 2014 May 06; 12:113. PMID: 24885155.
    Citations: 1     Fields:    Translation:HumansCells
  27. Mahmud SA, Manlove LS, Schmitz HM, Xing Y, Wang Y, Owen DL, Schenkel JM, Boomer JS, Green JM, Yagita H, Chi H, Hogquist KA, Farrar MA. Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells. Nat Immunol. 2014 May; 15(5):473-81. PMID: 24633226.
    Citations: 56     Fields:    Translation:AnimalsCells
  28. Schenkel JM, Fraser KA, Masopust D. Cutting edge: resident memory CD8 T cells occupy frontline niches in secondary lymphoid organs. J Immunol. 2014 Apr 01; 192(7):2961-4. PMID: 24600038.
    Citations: 51     Fields:    Translation:AnimalsCells
  29. Sakai S, Kauffman KD, Schenkel JM, McBerry CC, Mayer-Barber KD, Masopust D, Barber DL. Cutting edge: control of Mycobacterium tuberculosis infection by a subset of lung parenchyma-homing CD4 T cells. J Immunol. 2014 Apr 01; 192(7):2965-9. PMID: 24591367.
    Citations: 54     Fields:    Translation:AnimalsCells
  30. Schenkel JM, Masopust D. Identification of a resident T-cell memory core transcriptional signature. Immunol Cell Biol. 2014 Jan; 92(1):8-9. PMID: 24165982.
    Citations: 2     Fields:    Translation:AnimalsCells
  31. Fraser KA, Schenkel JM, Jameson SC, Vezys V, Masopust D. Preexisting high frequencies of memory CD8+ T cells favor rapid memory differentiation and preservation of proliferative potential upon boosting. Immunity. 2013 Jul 25; 39(1):171-83. PMID: 23890070.
    Citations: 27     Fields:    Translation:AnimalsCells
  32. Masopust D, Schenkel JM. The integration of T cell migration, differentiation and function. Nat Rev Immunol. 2013 May; 13(5):309-20. PMID: 23598650.
    Citations: 133     Fields:    Translation:HumansAnimalsCells
  33. Schenkel JM, Fraser KA, Vezys V, Masopust D. Sensing and alarm function of resident memory CD8? T cells. Nat Immunol. 2013 May; 14(5):509-13. PMID: 23542740.
    Citations: 138     Fields:    Translation:AnimalsCells
  34. Casey KA, Fraser KA, Schenkel JM, Moran A, Abt MC, Beura LK, Lucas PJ, Artis D, Wherry EJ, Hogquist K, Vezys V, Masopust D. Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues. J Immunol. 2012 May 15; 188(10):4866-75. PMID: 22504644.
    Citations: 146     Fields:    Translation:AnimalsCells
  35. Zloza A, Kohlhapp FJ, Lyons GE, Schenkel JM, Moore TV, Lacek AT, O'Sullivan JA, Varanasi V, Williams JW, Jagoda MC, Bellavance EC, Marzo AL, Thomas PG, Zafirova B, Polic B, Al-Harthi L, Sperling AI, Guevara-Patiño JA. NKG2D signaling on CD8? T cells represses T-bet and rescues CD4-unhelped CD8? T cell memory recall but not effector responses. Nat Med. 2012 Feb 26; 18(3):422-8. PMID: 22366950.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  36. Hamilton SE, Schenkel JM, Akue AD, Jameson SC. IL-2 complex treatment can protect naive mice from bacterial and viral infection. J Immunol. 2010 Dec 01; 185(11):6584-90. PMID: 21037095.
    Citations: 20     Fields:    Translation:AnimalsCells
  37. Schenkel JM, Zloza A, Li W, Narasipura SD, Al-Harthi L. Beta-catenin signaling mediates CD4 expression on mature CD8+ T cells. J Immunol. 2010 Aug 15; 185(4):2013-9. PMID: 20631314.
    Citations: 6     Fields:    Translation:HumansCells
  38. Zloza A, Schenkel JM, Tenorio AR, Martinson JA, Jeziorczak PM, Al-Harthi L. Potent HIV-specific responses are enriched in a unique subset of CD8+ T cells that coexpresses CD4 on its surface. Blood. 2009 Oct 29; 114(18):3841-53. PMID: 19700667.
    Citations: 12     Fields:    Translation:HumansCells
  39. Martin-Villalba A, Hahne M, Kleber S, Vogel J, Falk W, Schenkel J, Krammer PH. Therapeutic neutralization of CD95-ligand and TNF attenuates brain damage in stroke. Cell Death Differ. 2001 Jul; 8(7):679-86. PMID: 11464212.
  40. Marti A, Ritter PM, Jäger R, Lazar H, Baltzer A, Schenkel J, Declercq W, Vandenabeele P, Jaggi R. Mouse mammary gland involution is associated with cytochrome c release and caspase activation. Mech Dev. 2001 Jun; 104(1-2):89-98. PMID: 11404083.
  41. Schorpp M, Jäger R, Schellander K, Schenkel J, Wagner EF, Weiher H, Angel P. The human ubiquitin C promoter directs high ubiquitous expression of transgenes in mice. Nucleic Acids Res. 1996 May 01; 24(9):1787-8. PMID: 8650001.
  42. Knobloch M, Schönrich G, Schenkel J, Malissen M, Malissen B, Schmitt-Verhulst AM, Hämmerling GJ, Arnold B. T cell activation and thymic tolerance induction require different adhesion intensities of the CD8 co-receptor. Int Immunol. 1992 Oct; 4(10):1169-74. PMID: 1489732.
  43. Schenkel J, Schäfer H, Koch S, Burger R. Production of antibodies to the constant region of the mouse T-cell-receptor beta-chain. APMIS. 1991 Jan; 99(1):99-102. PMID: 1825170.
  44. Schäfer H, Müller B, Bader A, Schenkel J, Burger R. Analysis of guinea pig leukocyte antigens using interspecies T cell hybrids. J Immunol Methods. 1989 Mar 31; 118(2):169-77. PMID: 2784470.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.