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Daniel Richard Zeve, Ph.D., M.D.

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Mentoring
Available: 01/10/22, Expires: 03/01/25

Multiple hormones produced in the intestine can control appetite, making them excellent targets for obesity therapies. However, the cells that make these hormones (enteroendocrine (EE) cells) are rare, and there is a lack of understanding around what controls their differentiation and production of certain hormones. Our lab (I work in David Breault's lab) is focused on trying to understand the molecular mechanisms that drive human intestinal stem cells to become EE cells, and what drives the production and secretion of specific hormones. By doing this, we hope to elucidate druggable targets for future obesity-specific therapies. The majority of our studies use primary human intestinal stem cells grown in vitro using the 3D-organoid system to model the functional intestine. Aside from tissue culture, we also do quantitative PCR, immunofluorescence staining, flow cytometry, and ELISAs. Prior lab experience is helpful but not necessary. We currently have multiple ongoing studies, looking at different aspects of the EE lineage, any of which a student could work on (from understanding what drives a stem cell to differentiate to what causes an EE cell to produce and secrete a hormone). We also have some large datasets a student could look through to identify a new transcriptional target to analyze.


Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Milioto A, Reyes M, Hanna P, Kiuchi Z, Turan S, Zeve D, Agarwal C, Grigelioniene G, Chen A, Mericq V, Frangos M, Ten S, Mantovani G, Salusky IB, Tebben P, Jüppner H. Lack of GNAS Remethylation During Oogenesis May Be a Cause of Sporadic Pseudohypoparathyroidism Type Ib. J Clin Endocrinol Metab. 2022 Mar 24; 107(4):e1610-e1619. PMID: 34791361.
    Citations: 1     Fields:    
  2. Zeve D, Stas E, de Sousa Casal J, Mannam P, Qi W, Yin X, Dubois S, Shah MS, Syverson EP, Hafner S, Karp JM, Carlone DL, Ordovas-Montanes J, Breault DT. Robust differentiation of human enteroendocrine cells from intestinal stem cells. Nat Commun. 2022 01 11; 13(1):261. PMID: 35017529.
    Citations:    Fields:    Translation:HumansCells
  3. Ahmed F, Zeve D, Millington K, Rea C. 11-year old boy with facial hair, acne and deepened voice. BMJ Case Rep. 2019 Mar 20; 12(3). PMID: 30898952.
    Citations:    Fields:    Translation:Humans
  4. Zeve D, Regelmann MO, Holzman IR, Rapaport R. Small at Birth, but How Small? The Definition of SGA Revisited. Horm Res Paediatr. 2016; 86(5):357-360. PMID: 27685026.
    Citations: 17     Fields:    Translation:Humans
  5. Zeve D, Millay DP, Seo J, Graff JM. Exercise-Induced Skeletal Muscle Adaptations Alter the Activity of Adipose Progenitor Cells. PLoS One. 2016; 11(3):e0152129. PMID: 27015423.
    Citations: 6     Fields:    Translation:AnimalsCells
  6. Lapid K, Lim A, Clegg DJ, Zeve D, Graff JM. Oestrogen signalling in white adipose progenitor cells inhibits differentiation into brown adipose and smooth muscle cells. Nat Commun. 2014 Oct 21; 5:5196. PMID: 25330806.
    Citations: 19     Fields:    Translation:AnimalsCells
  7. Berry DC, Stenesen D, Zeve D, Graff JM. The developmental origins of adipose tissue. Development. 2013 Oct; 140(19):3939-49. PMID: 24046315.
    Citations: 120     Fields:    Translation:HumansAnimalsCells
  8. Davis KE, D Neinast M, Sun K, M Skiles W, D Bills J, A Zehr J, Zeve D, D Hahner L, W Cox D, M Gent L, Xu Y, V Wang Z, A Khan S, Clegg DJ. The sexually dimorphic role of adipose and adipocyte estrogen receptors in modulating adipose tissue expansion, inflammation, and fibrosis. Mol Metab. 2013; 2(3):227-42. PMID: 24049737.
    Citations: 107     Fields:    
  9. Zeve D, Seo J, Suh JM, Stenesen D, Tang W, Berglund ED, Wan Y, Williams LJ, Lim A, Martinez MJ, McKay RM, Millay DP, Olson EN, Graff JM. Wnt signaling activation in adipose progenitors promotes insulin-independent muscle glucose uptake. Cell Metab. 2012 Apr 04; 15(4):492-504. PMID: 22482731.
    Citations: 44     Fields:    Translation:AnimalsCells
  10. Wei W, Zeve D, Wang X, Du Y, Tang W, Dechow PC, Graff JM, Wan Y. Osteoclast progenitors reside in the peroxisome proliferator-activated receptor ?-expressing bone marrow cell population. Mol Cell Biol. 2011 Dec; 31(23):4692-705. PMID: 21947280.
    Citations: 27     Fields:    Translation:AnimalsCells
  11. Wei W, Zeve D, Suh JM, Wang X, Du Y, Zerwekh JE, Dechow PC, Graff JM, Wan Y. Biphasic and dosage-dependent regulation of osteoclastogenesis by ß-catenin. Mol Cell Biol. 2011 Dec; 31(23):4706-19. PMID: 21876000.
    Citations: 93     Fields:    Translation:AnimalsCells
  12. Tang W, Zeve D, Seo J, Jo AY, Graff JM. Thiazolidinediones regulate adipose lineage dynamics. Cell Metab. 2011 Jul 06; 14(1):116-22. PMID: 21723509.
    Citations: 43     Fields:    Translation:AnimalsCells
  13. Zeve D, Tang W, Graff J. Fighting fat with fat: the expanding field of adipose stem cells. Cell Stem Cell. 2009 Nov 06; 5(5):472-81. PMID: 19896439.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  14. Tang W, Zeve D, Suh JM, Bosnakovski D, Kyba M, Hammer RE, Tallquist MD, Graff JM. White fat progenitor cells reside in the adipose vasculature. Science. 2008 Oct 24; 322(5901):583-6. PMID: 18801968.
    Citations: 481     Fields:    Translation:AnimalsCells
  15. Suh JM, Zeve D, McKay R, Seo J, Salo Z, Li R, Wang M, Graff JM. Adipose is a conserved dosage-sensitive antiobesity gene. Cell Metab. 2007 Sep; 6(3):195-207. PMID: 17767906.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  16. Benjamin LT, Whitaker JL, Ramsey RM, Zeve DR. John B. Watson's alleged sex research: an appraisal of the evidence. Am Psychol. 2007 Feb-Mar; 62(2):131-9. PMID: 17324038.
    Citations:    Fields:    Translation:Humans
  17. Smith AM, Zeve DR, Dohrman DP, Chen WJ. The interactive effect of alcohol and nicotine on NGF-treated pheochromocytoma cells. Alcohol. 2006 Jun; 39(2):65-72. PMID: 17134658.
    Citations: 2     Fields:    Translation:AnimalsCells
  18. Frank-Cannon TC, Zeve DR, Abbott LC. Developmental expression of neuronal nitric oxide synthase in P/Q-type voltage-gated calcium ion channel mutant mice, leaner and tottering. Brain Res. 2007 Apr 06; 1140:96-104. PMID: 16359645.
    Citations: 2     Fields:    Translation:AnimalsCells
  19. Smith AM, Zeve DR, Grisel JJ, Chen WJ. Neonatal alcohol exposure increases malondialdehyde (MDA) and glutathione (GSH) levels in the developing cerebellum. Brain Res Dev Brain Res. 2005 Dec 07; 160(2):231-8. PMID: 16256207.
    Citations: 15     Fields:    Translation:Animals
  20. Wu H, Prince JE, Brayton CF, Shah C, Zeve D, Gregory SH, Smith CW, Ballantyne CM. Host resistance of CD18 knockout mice against systemic infection with Listeria monocytogenes. Infect Immun. 2003 Oct; 71(10):5986-93. PMID: 14500519.
    Citations: 6     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.