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Zachary D Nagel, Ph.D.

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Research
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  1. U01ES029520 (NAGEL, ZACHARY DAVID) Sep 15, 2018 - Jun 30, 2023
    NIH/NIEHS
    Multi-Pathway DNA Repair Capacity Measurements in Lung Cancer Patients and Healthy Controls
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Koyen AE, Madden MZ, Park D, Minten EV, Kapoor-Vazirani P, Werner E, Pfister NT, Haji-Seyed-Javadi R, Zhang H, Xu J, Deng N, Duong DM, Pecen TJ, Frazier Z, Nagel ZD, Lazaro JB, Mouw KW, Seyfried NT, Moreno CS, Owonikoko TK, Deng X, Yu DS. EZH2 has a non-catalytic and PRC2-independent role in stabilizing DDB2 to promote nucleotide excision repair. Oncogene. 2020 Jun; 39(25):4798-4813. PMID: 32457468.
    Citations:    
  2. O'Sullivan MJ, Mitchel JA, Das A, Koehler S, Levine H, Bi D, Nagel ZD, Park JA. Irradiation Induces Epithelial Cell Unjamming. Front Cell Dev Biol. 2020; 8:21. PMID: 32117962.
    Citations:    
  3. Houl JH, Ye Z, Brosey CA, Balapiti-Modarage LPF, Namjoshi S, Bacolla A, Laverty D, Walker BL, Pourfarjam Y, Warden LS, Babu Chinnam N, Moiani D, Stegeman RA, Chen MK, Hung MC, Nagel ZD, Ellenberger T, Kim IK, Jones DE, Ahmed Z, Tainer JA. Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death. Nat Commun. 2019 12 11; 10(1):5654. PMID: 31827085.
    Citations:    
  4. Russo M, Crisafulli G, Sogari A, Reilly NM, Arena S, Lamba S, Bartolini A, Amodio V, Magrì A, Novara L, Sarotto I, Nagel ZD, Piett CG, Amatu A, Sartore-Bianchi A, Siena S, Bertotti A, Trusolino L, Corigliano M, Gherardi M, Lagomarsino MC, Di Nicolantonio F, Bardelli A. Adaptive mutability of colorectal cancers in response to targeted therapies. Science. 2019 12 20; 366(6472):1473-1480. PMID: 31699882.
    Citations:    
  5. Lee KJ, Piett CG, Andrews JF, Mann E, Nagel ZD, Gassman NR. Defective base excision repair in the response to DNA damaging agents in triple negative breast cancer. PLoS One. 2019; 14(10):e0223725. PMID: 31596905.
    Citations:    
  6. Xiao AY, Maynard MR, Piett CG, Nagel ZD, Alexander JS, Kevil CG, Berridge MV, Pattillo CB, Rosen LR, Miriyala S, Harrison L. Sodium sulfide selectively induces oxidative stress, DNA damage, and mitochondrial dysfunction and radiosensitizes glioblastoma (GBM) cells. Redox Biol. 2019 09; 26:101220. PMID: 31176262.
    Citations:    
  7. Chan EM, Shibue T, McFarland JM, Gaeta B, Ghandi M, Dumont N, Gonzalez A, McPartlan JS, Li T, Zhang Y, Bin Liu J, Lazaro JB, Gu P, Piett CG, Apffel A, Ali SO, Deasy R, Keskula P, Ng RWS, Roberts EA, Reznichenko E, Leung L, Alimova M, Schenone M, Islam M, Maruvka YE, Liu Y, Roper J, Raghavan S, Giannakis M, Tseng YY, Nagel ZD, D'Andrea A, Root DE, Boehm JS, Getz G, Chang S, Golub TR, Tsherniak A, Vazquez F, Bass AJ. WRN helicase is a synthetic lethal target in microsatellite unstable cancers. Nature. 2019 04; 568(7753):551-556. PMID: 30971823.
    Citations:    
  8. Nagel ZD, Beharry AA, Mazzucato P, Kitange GJ, Sarkaria JN, Kool ET, Samson LD. Fluorescent reporter assays provide direct, accurate, quantitative measurements of MGMT status in human cells. PLoS One. 2019; 14(2):e0208341. PMID: 30811507.
    Citations:    
  9. Moore S, Berger ND, Luijsterburg MS, Piett CG, Stanley FKT, Schräder CU, Fang S, Chan JA, Schriemer DC, Nagel ZD, van Attikum H, Goodarzi AA. The CHD6 chromatin remodeler is an oxidative DNA damage response factor. Nat Commun. 2019 01 16; 10(1):241. PMID: 30651562.
    Citations:    Fields:    
  10. Shen J, Ju Z, Zhao W, Wang L, Peng Y, Ge Z, Nagel ZD, Zou J, Wang C, Kapoor P, Ma X, Ma D, Liang J, Song S, Liu J, Samson LD, Ajani JA, Li GM, Liang H, Shen X, Mills GB, Peng G. ARID1A deficiency promotes mutability and potentiates therapeutic antitumor immunity unleashed by immune checkpoint blockade. Nat Med. 2018 05; 24(5):556-562. PMID: 29736026.
    Citations: 1     Fields:    
  11. Parrish MC, Chaim IA, Nagel ZD, Tannenbaum SR, Samson LD, Engelward BP. Nitric oxide induced S-nitrosation causes base excision repair imbalance. DNA Repair (Amst). 2018 08; 68:25-33. PMID: 29929044.
    Citations:    Fields:    Translation:AnimalsCells
  12. Chaim IA, Nagel ZD, Jordan JJ, Mazzucato P, Ngo LP, Samson LD. In vivo measurements of interindividual differences in DNA glycosylases and APE1 activities. Proc Natl Acad Sci U S A. 2017 11 28; 114(48):E10379-E10388. PMID: 29122935.
    Citations: 1     Fields:    Translation:HumansCells
  13. Nagel ZD, Engelward BP, Brenner DJ, Begley TJ, Sobol RW, Bielas JH, Stambrook PJ, Wei Q, Hu JJ, Terry MB, Dilworth C, McAllister KA, Reinlib L, Worth L, Shaughnessy DT. Towards precision prevention: Technologies for identifying healthy individuals with high risk of disease. Mutat Res. 2017 08; 800-802:14-28. PMID: 28458064.
    Citations:    Fields:    Translation:HumansCells
  14. Nagel ZD, Kitange GJ, Gupta SK, Joughin BA, Chaim IA, Mazzucato P, Lauffenburger DA, Sarkaria JN, Samson LD. DNA Repair Capacity in Multiple Pathways Predicts Chemoresistance in Glioblastoma Multiforme. Cancer Res. 2017 01 01; 77(1):198-206. PMID: 27793847.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  15. Beharry AA, Nagel ZD, Samson LD, Kool ET. Fluorogenic Real-Time Reporters of DNA Repair by MGMT, a Clinical Predictor of Antitumor Drug Response. PLoS One. 2016; 11(4):e0152684. PMID: 27035132.
    Citations: 1     Fields:    Translation:HumansCells
  16. McFaline-Figueroa JL, Braun CJ, Stanciu M, Nagel ZD, Mazzucato P, Sangaraju D, Cerniauskas E, Barford K, Vargas A, Chen Y, Tretyakova N, Lees JA, Hemann MT, White FM, Samson LD. Minor Changes in Expression of the Mismatch Repair Protein MSH2 Exert a Major Impact on Glioblastoma Response to Temozolomide. Cancer Res. 2015 Aug 01; 75(15):3127-38. PMID: 26025730.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  17. Nagel ZD, Chaim IA, Samson LD. Inter-individual variation in DNA repair capacity: a need for multi-pathway functional assays to promote translational DNA repair research. DNA Repair (Amst). 2014 Jul; 19:199-213. PMID: 24780560.
    Citations: 8     Fields:    Translation:HumansCells
  18. Nagel ZD, Margulies CM, Chaim IA, McRee SK, Mazzucato P, Ahmad A, Abo RP, Butty VL, Forget AL, Samson LD. Multiplexed DNA repair assays for multiple lesions and multiple doses via transcription inhibition and transcriptional mutagenesis. Proc Natl Acad Sci U S A. 2014 May 06; 111(18):E1823-32. PMID: 24757057.
    Citations: 27     Fields:    Translation:HumansCells
  19. Nagel ZD, Cun S, Klinman JP. Identification of a long-range protein network that modulates active site dynamics in extremophilic alcohol dehydrogenases. J Biol Chem. 2013 May 17; 288(20):14087-97. PMID: 23525111.
    Citations: 15     Fields:    Translation:Cells
  20. Nagel ZD, Meadows CW, Dong M, Bahnson BJ, Klinman JP. Active site hydrophobic residues impact hydrogen tunneling differently in a thermophilic alcohol dehydrogenase at optimal versus nonoptimal temperatures. Biochemistry. 2012 May 22; 51(20):4147-56. PMID: 22568562.
    Citations: 14     Fields:    Translation:Cells
  21. Nagel ZD, Dong M, Bahnson BJ, Klinman JP. Impaired protein conformational landscapes as revealed in anomalous Arrhenius prefactors. Proc Natl Acad Sci U S A. 2011 Jun 28; 108(26):10520-5. PMID: 21670258.
    Citations: 24     Fields:    Translation:Cells
  22. Nagel ZD, Klinman JP. Update 1 of: Tunneling and dynamics in enzymatic hydride transfer. Chem Rev. 2010 Dec 08; 110(12):PR41-67. PMID: 21141912.
    Citations: 45     Fields:    
  23. Nagel ZD, Klinman JP. A 21st century revisionist's view at a turning point in enzymology. Nat Chem Biol. 2009 Aug; 5(8):543-50. PMID: 19620995.
    Citations: 87     Fields:    Translation:Cells
  24. Miqyass M, Marosvölgyi MA, Nagel Z, Yocum CF, van Gorkom HJ. S-state dependence of the calcium requirement and binding characteristics in the oxygen-evolving complex of photosystem II. Biochemistry. 2008 Jul 29; 47(30):7915-24. PMID: 18593200.
    Citations: 5     Fields:    Translation:AnimalsCells
  25. Nagel ZD, Klinman JP. Tunneling and dynamics in enzymatic hydride transfer. Chem Rev. 2006 Aug; 106(8):3095-118. PMID: 16895320.
    Citations: 71     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.