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profileZachary D Nagel, Ph.D.

TitleAssistant Professor of Radiation Biology
InstitutionHarvard T.H. Chan School of Public Health
DepartmentEH - John B Little Ctr for Radiation Sciences
AddressHarvard Chan School of Public Health
Goldenson 559C
220 Longwood Ave
Boston MA 02115
Phone617/432-1021
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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Nagel ZD, Kitange GJ, Gupta SK, Joughin BA, Chaim IA, Mazzucato P, Lauffenburger DA, Sarkaria JN, Samson LD. DNA Repair Capacity in Multiple Pathways Predicts Chemoresistance in Glioblastoma Multiforme. Cancer Res. 2017 Jan 01; 77(1):198-206. PMID: 27793847.
    View in: PubMed
  2. Beharry AA, Nagel ZD, Samson LD, Kool ET. Fluorogenic Real-Time Reporters of DNA Repair by MGMT, a Clinical Predictor of Antitumor Drug Response. PLoS One. 2016; 11(4):e0152684. PMID: 27035132; PMCID: PMC4818092.
  3. McFaline-Figueroa JL, Braun CJ, Stanciu M, Nagel ZD, Mazzucato P, Sangaraju D, Cerniauskas E, Barford K, Vargas A, Chen Y, Tretyakova N, Lees JA, Hemann MT, White FM, Samson LD. Minor Changes in Expression of the Mismatch Repair Protein MSH2 Exert a Major Impact on Glioblastoma Response to Temozolomide. Cancer Res. 2015 Aug 01; 75(15):3127-38. PMID: 26025730; PMCID: PMC4526337.
  4. Nagel ZD, Chaim IA, Samson LD. Inter-individual variation in DNA repair capacity: a need for multi-pathway functional assays to promote translational DNA repair research. DNA Repair (Amst). 2014 Jul; 19:199-213. PMID: 24780560; PMCID: PMC4071454.
  5. Nagel ZD, Margulies CM, Chaim IA, McRee SK, Mazzucato P, Ahmad A, Abo RP, Butty VL, Forget AL, Samson LD. Multiplexed DNA repair assays for multiple lesions and multiple doses via transcription inhibition and transcriptional mutagenesis. Proc Natl Acad Sci U S A. 2014 May 06; 111(18):E1823-32. PMID: 24757057; PMCID: PMC4020053.
  6. Nagel ZD, Cun S, Klinman JP. Identification of a long-range protein network that modulates active site dynamics in extremophilic alcohol dehydrogenases. J Biol Chem. 2013 May 17; 288(20):14087-97. PMID: 23525111; PMCID: PMC3656266.
  7. Nagel ZD, Meadows CW, Dong M, Bahnson BJ, Klinman JP. Active site hydrophobic residues impact hydrogen tunneling differently in a thermophilic alcohol dehydrogenase at optimal versus nonoptimal temperatures. Biochemistry. 2012 May 22; 51(20):4147-56. PMID: 22568562; PMCID: PMC3498984.
  8. Nagel ZD, Dong M, Bahnson BJ, Klinman JP. Impaired protein conformational landscapes as revealed in anomalous Arrhenius prefactors. Proc Natl Acad Sci U S A. 2011 Jun 28; 108(26):10520-5. PMID: 21670258; PMCID: PMC3127881.
  9. Nagel ZD, Klinman JP. Update 1 of: Tunneling and dynamics in enzymatic hydride transfer. Chem Rev. 2010 Dec 08; 110(12):PR41-67. PMID: 21141912; PMCID: PMC4067601.
  10. Nagel ZD, Klinman JP. A 21st century revisionist's view at a turning point in enzymology. Nat Chem Biol. 2009 Aug; 5(8):543-50. PMID: 19620995.
    View in: PubMed
  11. Miqyass M, Marosvölgyi MA, Nagel Z, Yocum CF, van Gorkom HJ. S-state dependence of the calcium requirement and binding characteristics in the oxygen-evolving complex of photosystem II. Biochemistry. 2008 Jul 29; 47(30):7915-24. PMID: 18593200.
    View in: PubMed
  12. Nagel ZD, Klinman JP. Tunneling and dynamics in enzymatic hydride transfer. Chem Rev. 2006 Aug; 106(8):3095-118. PMID: 16895320.
    View in: PubMed
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