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Oliver Jonas, Ph.D.

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Mentoring
Available: 10/17/18, Expires: 07/31/20

We develop microdevices that are implanted directly into native tissue to perform a comprehensive physiological characterization of native tissue. Devices have up to 30 microreservoirs that each have a distinct drug or molecular probe. We measure the tissue response to each reservoir, and use this data to design optimal therapy in cancer and other diseases.


Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA232174 (JONAS, OLIVER) Mar 4, 2019 - Feb 29, 2024
    NIH/NCI
    Pilot study of an implantable microdevice to test multiple drug responses in prostate cancer patients
    Role: Principal Investigator
  2. R01CA223150 (JONAS, OLIVER) Jul 1, 2018 - Jun 30, 2023
    NIH/NCI
    In Situ characterization and manipulation of tumor immune cell metabolomics using implantable microdevices
    Role: Principal Investigator
  3. R01CA224144 (JONAS, OLIVER) Mar 15, 2018 - Feb 28, 2022
    NIH/NCI
    Implantable microdevices with integrated optical imaging for high-throughput in situ tumor response and drug sensitivity measurement
    Role: Principal Investigator
  4. R37CA224144 (JONAS, OLIVER) Mar 15, 2018 - Feb 28, 2022
    NIH/NCI
    Implantable microdevices with integrated optical imaging for high-throughput in situ tumor response and drug sensitivity measurement
    Role: Principal Investigator
  5. R21CA216796 (JONAS, OLIVER) Jan 8, 2018 - Dec 31, 2019
    NIH/NCI
    Clinical Evaluation of an Implantable Lab-in-a-patient microdevice that measures in-situ response to therapies in advanced ovarian cancer
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Jonas O, Kang JW, Singh SP, Lammers A, Nguyen FT, Dasari RR, So PTC, Langer R, Cima MJ. In vivo detection of drug-induced apoptosis in tumors using Raman spectroscopy. Analyst. 2018 Oct 08; 143(20):4836-4839. PMID: 30070266.
    Citations:    Fields:    Translation:Animals
  2. Arai S, Jonas O, Whitman MA, Corey E, Balk SP, Chen S. Tyrosine Kinase Inhibitors Increase MCL1 Degradation and in Combination with BCLXL/BCL2 Inhibitors Drive Prostate Cancer Apoptosis. Clin Cancer Res. 2018 Nov 01; 24(21):5458-5470. PMID: 30021909.
    Citations:    Fields:    
  3. Watson SS, Dane M, Chin K, Tatarova Z, Liu M, Liby T, Thompson W, Smith R, Nederlof M, Bucher E, Kilburn D, Whitman M, Sudar D, Mills GB, Heiser LM, Jonas O, Gray JW, Korkola JE. Microenvironment-Mediated Mechanisms of Resistance to HER2 Inhibitors Differ between HER2+ Breast Cancer Subtypes. Cell Syst. 2018 Mar 28; 6(3):329-342.e6. PMID: 29550255.
    Citations:    Fields:    
  4. Geller LT, Barzily-Rokni M, Danino T, Jonas OH, Shental N, Nejman D, Gavert N, Zwang Y, Cooper ZA, Shee K, Thaiss CA, Reuben A, Livny J, Avraham R, Frederick DT, Ligorio M, Chatman K, Johnston SE, Mosher CM, Brandis A, Fuks G, Gurbatri C, Gopalakrishnan V, Kim M, Hurd MW, Katz M, Fleming J, Maitra A, Smith DA, Skalak M, Bu J, Michaud M, Trauger SA, Barshack I, Golan T, Sandbank J, Flaherty KT, Mandinova A, Garrett WS, Thayer SP, Ferrone CR, Huttenhower C, Bhatia SN, Gevers D, Wargo JA, Golub TR, Straussman R. Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine. Science. 2017 09 15; 357(6356):1156-1160. PMID: 28912244.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  5. Zwang Y, Jonas O, Chen C, Rinne ML, Doench JG, Piccioni F, Tan L, Huang HT, Wang J, Ham YJ, O'Connell J, Bhola P, Doshi M, Whitman M, Cima M, Letai A, Root DE, Langer RS, Gray N, Hahn WC. Synergistic interactions with PI3K inhibition that induce apoptosis. Elife. 2017 05 31; 6. PMID: 28561737.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  6. Davidson SM, Jonas O, Keibler MA, Hou HW, Luengo A, Mayers JR, Wyckoff J, Del Rosario AM, Whitman M, Chin CR, Condon KJ, Lammers A, Kellersberger KA, Stall BK, Stephanopoulos G, Bar-Sagi D, Han J, Rabinowitz JD, Cima MJ, Langer R, Vander Heiden MG. Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors. Nat Med. 2017 Feb; 23(2):235-241. PMID: 28024083.
    Citations: 24     Fields:    Translation:AnimalsCells
  7. Oudin MJ, Barbier L, Schäfer C, Kosciuk T, Miller MA, Han S, Jonas O, Lauffenburger DA, Gertler FB. MENA Confers Resistance to Paclitaxel in Triple-Negative Breast Cancer. Mol Cancer Ther. 2017 01; 16(1):143-155. PMID: 27811011.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  8. Hong AL, Tseng YY, Cowley GS, Jonas O, Cheah JH, Kynnap BD, Doshi MB, Oh C, Meyer SC, Church AJ, Gill S, Bielski CM, Keskula P, Imamovic A, Howell S, Kryukov GV, Clemons PA, Tsherniak A, Vazquez F, Crompton BD, Shamji AF, Rodriguez-Galindo C, Janeway KA, Roberts CW, Stegmaier K, van Hummelen P, Cima MJ, Langer RS, Garraway LA, Schreiber SL, Root DE, Hahn WC, Boehm JS. Integrated genetic and pharmacologic interrogation of rare cancers. Nat Commun. 2016 06 22; 7:11987. PMID: 27329820.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  9. Jonas O, Calligaris D, Methuku KR, Poe MM, Francois JP, Tranghese F, Changelian A, Sieghart W, Ernst M, Krummel DA, Cook JM, Pomeroy SL, Cima M, Agar NY, Langer R, Sengupta S. First In Vivo Testing of Compounds Targeting Group 3 Medulloblastomas Using an Implantable Microdevice as a New Paradigm for Drug Development. J Biomed Nanotechnol. 2016 Jun; 12(6):1297-302. PMID: 27319222.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  10. Jonas O, Oudin MJ, Kosciuk T, Whitman M, Gertler FB, Cima MJ, Flaherty KT, Langer R. Parallel In Vivo Assessment of Drug Phenotypes at Various Time Points during Systemic BRAF Inhibition Reveals Tumor Adaptation and Altered Treatment Vulnerabilities. Clin Cancer Res. 2016 Dec 15; 22(24):6031-6038. PMID: 27091406.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  11. Oudin MJ, Jonas O, Kosciuk T, Broye LC, Guido BC, Wyckoff J, Riquelme D, Lamar JM, Asokan SB, Whittaker C, Ma D, Langer R, Cima MJ, Wisinski KB, Hynes RO, Lauffenburger DA, Keely PJ, Bear JE, Gertler FB. Tumor Cell-Driven Extracellular Matrix Remodeling Drives Haptotaxis during Metastatic Progression. Cancer Discov. 2016 05; 6(5):516-31. PMID: 26811325; PMCID: PMC4854754.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  12. Jonas O, Landry HM, Fuller JE, Santini JT, Baselga J, Tepper RI, Cima MJ, Langer R. An implantable microdevice to perform high-throughput in vivo drug sensitivity testing in tumors. Sci Transl Med. 2015 Apr 22; 7(284):284ra57. PMID: 25904741; PMCID: PMC4825177.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  13. Jonas O, Duschl C. Force propagation and force generation in cells. Cytoskeleton (Hoboken). 2010 Sep; 67(9):555-63. PMID: 20607861.
    Citations: 3     Fields:    Translation:AnimalsCells
  14. Cogswell LP, Raines DE, Parekh S, Jonas O, Maggio JE, Strichartz GR. Development of a novel probe for measuring drug binding to the F1*S variant of human alpha 1-acid glycoprotein. J Pharm Sci. 2001 Sep; 90(9):1407-23. PMID: 11745793.
    Citations:    Fields:    Translation:HumansCells
  15. Jonas O, Roder D. Breech presentation in South Australia, 1987-1989. Aust N Z J Obstet Gynaecol. 1993 Feb; 33(1):17-21. PMID: 8498932.
    Citations: 1     Fields:    Translation:Humans
  16. Jonas O, Roder D, Chan A. The association of low socio-economic status in metropolitan Adelaide with maternal demographic and obstetric characteristics and pregnancy outcome. Eur J Epidemiol. 1992 Sep; 8(5):708-14. PMID: 1426171.
    Citations: 2     Fields:    Translation:Humans
  17. Jonas O, Roder D, Chan A. The association of maternal and socioeconomic characteristics in metropolitan Adelaide with medical, obstetric and labour complications and pregnancy outcomes. Aust N Z J Obstet Gynaecol. 1992 Feb; 32(1):1-5. PMID: 1586324.
    Citations: 4     Fields:    Translation:Humans
  18. Jonas O, Chan A, Roder D, Macharper T. Pregnancy outcomes in primigravid women aged 35 years and over in South Australia, 1986-1988. Med J Aust. 1991 Feb 18; 154(4):246-9. PMID: 1994197.
    Citations: 3     Fields:    Translation:Humans
  19. Jonas O, Chan A, Macharper T, Roder D. Pregnancy and perinatal factors associated with persistently low Apgar scores: an analysis of the birth records of infants born in South Australia. Eur J Epidemiol. 1990 Jun; 6(2):136-41. PMID: 2361537.
    Citations: 1     Fields:    Translation:Humans
  20. Jonas O, Roder D, Esterman A, Macharper T, Chan A. Pregnancy and birth risk factors for intellectual disability in South Australia. Eur J Epidemiol. 1989 Sep; 5(3):322-7. PMID: 2792308.
    Citations: 3     Fields:    Translation:Humans
  21. Jonas O, Chan A, MacHarper T. Caesarean section in South Australia, 1986. Aust N Z J Obstet Gynaecol. 1989 May; 29(2):99-106. PMID: 2803135.
    Citations:    Fields:    Translation:Humans
  22. Jonas O, Stern LM, Macharper T. A South Australian study of pregnancy and birth risk factors associated with cerebral palsy. Int J Rehabil Res. 1989; 12(2):159-66. PMID: 2625375.
    Citations: 2     Fields:    Translation:Humans
  23. Jonas O, Smyth N. ipecacuanha-ipecauanha. Med J Aust. 1975 Apr 26; 1(17):534-5. PMID: 239305.
    Citations:    Fields:    Translation:Humans
  24. Jonas O. A study of patients attending the casualty department of a paediatric hospital. Med J Aust. 1974 Jun 08; 1(23):934-7. PMID: 4850321.
    Citations:    Fields:    Translation:Humans
  25. Jonas O. Ceroid storage in a child with a Niemann-Pick type syndrome. Med J Aust. 1966 Sep 17; 2(12):551-4. PMID: 5922340.
    Citations: 1     Fields:    Translation:HumansCells
  26. JONAS O. [Regional organization of prenatal care]. Prakt Lek. 1951 Jul 05; 31(13-14):303-4. PMID: 14875613.
    Citations:    Translation:Humans
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.