Harvard Catalyst Profiles

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Benjamin Joseph Orlando, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Fan M, Zhang J, Tsai CW, Orlando BJ, Rodriguez M, Xu Y, Liao M, Tsai MF, Feng L. Structure and mechanism of the mitochondrial Ca2+ uniporter holocomplex. Nature. 2020 06; 582(7810):129-133. PMID: 32494073.
    Citations:    
  2. Orlando BJ, Liao M. ABCG2 transports anticancer drugs via a closed-to-open switch. Nat Commun. 2020 May 08; 11(1):2264. PMID: 32385283.
    Citations:    
  3. Thélot F, Orlando BJ, Li Y, Liao M. High-resolution views of lipopolysaccharide translocation driven by ABC transporters MsbA and LptB2FGC. Curr Opin Struct Biol. 2020 Apr 23; 63:26-33. PMID: 32335504.
    Citations:    
  4. Chew TA, Orlando BJ, Zhang J, Latorraca NR, Wang A, Hollingsworth SA, Chen DH, Dror RO, Liao M, Feng L. Structure and mechanism of the cation-chloride cotransporter NKCC1. Nature. 2019 08; 572(7770):488-492. PMID: 31367042.
    Citations:    
  5. Giessen TW, Orlando BJ, Verdegaal AA, Chambers MG, Gardener J, Bell DC, Birrane G, Liao M, Silver PA. Large protein organelles form a new iron sequestration system with high storage capacity. Elife. 2019 07 08; 8. PMID: 31282860.
    Citations:    
  6. Li Y, Orlando BJ, Liao M. Structural basis of lipopolysaccharide extraction by the LptB2FGC complex. Nature. 2019 03; 567(7749):486-490. PMID: 30894744.
    Citations:    
  7. Fan C, Fan M, Orlando BJ, Fastman NM, Zhang J, Xu Y, Chambers MG, Xu X, Perry K, Liao M, Feng L. X-ray and cryo-EM structures of the mitochondrial calcium uniporter. Nature. 2018 07; 559(7715):575-579. PMID: 29995856.
    Citations:    Fields:    Translation:AnimalsCells
  8. Dong L, Yuan C, Orlando BJ, Malkowski MG, Smith WL. Fatty Acid Binding to the Allosteric Subunit of Cyclooxygenase-2 Relieves a Tonic Inhibition of the Catalytic Subunit. J Biol Chem. 2016 Dec 02; 291(49):25641-25655. PMID: 27756840.
    Citations: 1     Fields:    Translation:HumansCells
  9. Orlando BJ, Malkowski MG. Crystal structure of rofecoxib bound to human cyclooxygenase-2. Acta Crystallogr F Struct Biol Commun. 2016 10 01; 72(Pt 10):772-776. PMID: 27710942.
    Citations: 2     Fields:    Translation:HumansCellsPHPublic Health
  10. Orlando BJ, Malkowski MG. Substrate-selective Inhibition of Cyclooxygeanse-2 by Fenamic Acid Derivatives Is Dependent on Peroxide Tone. J Biol Chem. 2016 07 15; 291(29):15069-81. PMID: 27226593.
    Citations: 5     Fields:    Translation:HumansCells
  11. Lucido MJ, Orlando BJ, Vecchio AJ, Malkowski MG. Crystal Structure of Aspirin-Acetylated Human Cyclooxygenase-2: Insight into the Formation of Products with Reversed Stereochemistry. Biochemistry. 2016 Mar 01; 55(8):1226-38. PMID: 26859324.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  12. Orlando BJ, Borbat PP, Georgieva ER, Freed JH, Malkowski MG. Pulsed Dipolar Spectroscopy Reveals That Tyrosyl Radicals Are Generated in Both Monomers of the Cyclooxygenase-2 Dimer. Biochemistry. 2015 Dec 22; 54(50):7309-12. PMID: 26636181.
    Citations: 1     Fields:    Translation:Cells
  13. Orlando BJ, Lucido MJ, Malkowski MG. The structure of ibuprofen bound to cyclooxygenase-2. J Struct Biol. 2015 Jan; 189(1):62-6. PMID: 25463020.
    Citations: 9     Fields:    Translation:AnimalsCells
  14. Orlando BJ, McDougle DR, Lucido MJ, Eng ET, Graham LA, Schneider C, Stokes DL, Das A, Malkowski MG. Cyclooxygenase-2 catalysis and inhibition in lipid bilayer nanodiscs. Arch Biochem Biophys. 2014 Mar 15; 546:33-40. PMID: 24503478.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  15. Vecchio AJ, Orlando BJ, Nandagiri R, Malkowski MG. Investigating substrate promiscuity in cyclooxygenase-2: the role of Arg-120 and residues lining the hydrophobic groove. J Biol Chem. 2012 Jul 13; 287(29):24619-30. PMID: 22637474.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.