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Nikolaos Perakakis, M.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Tuccinardi D, Farr OM, Upadhyay J, Oussaada SM, Mathew H, Paschou SA, Perakakis N, Koniaris A, Kelesidis T, Mantzoros CS. Lorcaserin treatment decreases body weight and improves cardiometabolic risk factors of obese adults: A 6-month-long, randomized, placebo-controlled, double-blind clinical trial. Diabetes Obes Metab. 2019 Feb 06. PMID: 30724455.
    Citations:    
  2. Perakakis N, Kokkinos A, Peradze N, Tentolouris N, Ghaly W, Tsilingiris D, Alexandrou A, Mantzoros CS. Follistatins in glucose regulation in healthy and obese individuals. Diabetes Obes Metab. 2019 Mar; 21(3):683-690. PMID: 30393997.
    Citations:    Fields:    
  3. Anastasilakis AD, Koulaxis D, Upadhyay J, Pagkalidou E, Kefala N, Perakakis N, Polyzos SA, Economou F, Mantzoros CS. Free IGF-1, Intact IGFBP-4, and PicoPAPP-A are Altered in Acute Myocardial Infarction Compared to Stable Coronary Artery Disease and Healthy Controls. Horm Metab Res. 2019 Feb; 51(2):112-119. PMID: 30497090.
    Citations:    Fields:    
  4. Pilitsi E, Farr OM, Polyzos SA, Perakakis N, Nolen-Doerr E, Papathanasiou AE, Mantzoros CS. Pharmacotherapy of obesity: Available medications and drugs under investigation. Metabolism. 2019 Mar; 92:170-192. PMID: 30391259.
    Citations:    Fields:    
  5. Päth G, Perakakis N, Mantzoros CS, Seufert J. Stem cells in the treatment of diabetes mellitus - Focus on mesenchymal stem cells. Metabolism. 2019 Jan; 90:1-15. PMID: 30342065.
    Citations:    Fields:    
  6. Perakakis N, Mougios V, Fatouros I, Siopi A, Draganidis D, Peradze N, Ghaly W, Mantzoros CS. Physiology of Activins/Follistatins: Associations With Metabolic and Anthropometric Variables and Response to Exercise. J Clin Endocrinol Metab. 2018 Oct 01; 103(10):3890-3899. PMID: 30085147.
    Citations:    Fields:    
  7. Perakakis N, Yazdani A, Karniadakis GE, Mantzoros C. Omics, big data and machine learning as tools to propel understanding of biological mechanisms and to discover novel diagnostics and therapeutics. Metabolism. 2018 10; 87:A1-A9. PMID: 30098323.
    Citations: 1     Fields:    
  8. Perakakis N, Upadhyay J, Ghaly W, Chen J, Chrysafi P, Anastasilakis AD, Mantzoros CS. Regulation of the activins-follistatins-inhibins axis by energy status: Impact on reproductive function. Metabolism. 2018 08; 85:240-249. PMID: 29752954.
    Citations: 1     Fields:    
  9. Boutari C, Perakakis N, Mantzoros CS. Association of Adipokines with Development and Progression of Nonalcoholic Fatty Liver Disease. Endocrinol Metab (Seoul). 2018 Mar; 33(1):33-43. PMID: 29589386.
    Citations: 5     
  10. Perakakis N, Ghaly W, Peradze N, Boutari C, Batirel S, Douglas VP, Mantzoros CS. Research advances in metabolism 2017. Metabolism. 2018 06; 83:280-289. PMID: 29378200.
    Citations:    Fields:    Translation:Humans
  11. Liu C, Zhang W, Peradze N, Lang L, Straetener J, Feilen PJ, Alt M, Jäger C, Laubner K, Perakakis N, Seufert J, Päth G. Mesenchymal stem cell (MSC)-mediated survival of insulin producing pancreatic ß-cells during cellular stress involves signalling via Akt and ERK1/2. Mol Cell Endocrinol. 2018 09 15; 473:235-244. PMID: 29421520.
    Citations:    Fields:    
  12. Polyzos SA, Anastasilakis AD, Efstathiadou ZA, Makras P, Perakakis N, Kountouras J, Mantzoros CS. Irisin in metabolic diseases. Endocrine. 2018 02; 59(2):260-274. PMID: 29170905.
    Citations: 2     Fields:    Translation:Humans
  13. Batirel S, Yilmaz AM, Sahin A, Perakakis N, Kartal Ozer N, Mantzoros CS. Antitumor and antimetastatic effects of walnut oil in esophageal adenocarcinoma cells. Clin Nutr. 2018 Dec; 37(6 Pt A):2166-2171. PMID: 29126716.
    Citations:    Fields:    
  14. Upadhyay J, Farr O, Perakakis N, Ghaly W, Mantzoros C. Obesity as a Disease. Med Clin North Am. 2018 Jan; 102(1):13-33. PMID: 29156181.
    Citations: 4     Fields:    Translation:HumansPHPublic Health
  15. Alford S, Patel D, Perakakis N, Mantzoros CS. Obesity as a risk factor for Alzheimer's disease: weighing the evidence. Obes Rev. 2018 02; 19(2):269-280. PMID: 29024348.
    Citations: 1     Fields:    
  16. Upadhyay J, Polyzos SA, Perakakis N, Thakkar B, Paschou SA, Katsiki N, Underwood P, Park KH, Seufert J, Kang ES, Sternthal E, Karagiannis A, Mantzoros CS. Pharmacotherapy of type 2 diabetes: An update. Metabolism. 2018 01; 78:13-42. PMID: 28920861.
    Citations: 2     Fields:    Translation:HumansAnimals
  17. Perakakis N, Triantafyllou GA, Fernández-Real JM, Huh JY, Park KH, Seufert J, Mantzoros CS. Physiology and role of irisin in glucose homeostasis. Nat Rev Endocrinol. 2017 06; 13(6):324-337. PMID: 28211512.
    Citations: 14     Fields:    Translation:HumansAnimals
  18. Perakakis N, Farr OM, Tuccinardi D, Upadhyay J, Mantzoros CS. Research advances in metabolism 2016. Metabolism. 2017 02; 67:41-53. PMID: 28081777.
    Citations:    Fields:    Translation:HumansAnimals
  19. Liu X, Perakakis N, Gong H, Chamberland JP, Brinkoetter MT, Hamnvik OR, Mantzoros CS. Adiponectin administration prevents weight gain and glycemic profile changes in diet-induced obese immune deficient Rag1-/- mice lacking mature lymphocytes. Metabolism. 2016 Dec; 65(12):1720-1730. PMID: 27832860.
    Citations: 2     Fields:    Translation:AnimalsCells
  20. Perakakis N, Mantzoros CS. Immune therapy in type 1 diabetes mellitus - Attempts to untie the Gordian knot? Metabolism. 2016 09; 65(9):1278-85. PMID: 27506735.
    Citations: 1     Fields:    Translation:Humans
  21. Perakakis N, Flohr F, Kayser G, Thomusch O, Parsons L, Billmann F, von Dobschuetz E, Rondot S, Seufert J, Laubner K. Multiple endocrine neoplasia type 1 associated with a new germline Men1 mutation in a family with atypical tumor phenotype. Hormones (Athens). 2016 Jan-Mar; 15(1):113-7. PMID: 26732163.
    Citations:    Fields:    Translation:Humans
  22. Perakakis N, Danassi D, Alt M, Tsaroucha E, Mehana AE, Rimmer N, Laubner K, Wang H, Wollheim CB, Seufert J, Päth G. Human Krüppel-like factor 11 differentially regulates human insulin promoter activity in ß-cells and non-ß-cells via p300 and PDX1 through the regulatory sites A3 and CACCC box. Mol Cell Endocrinol. 2012 Nov 05; 363(1-2):20-6. PMID: 22801105.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  23. Perakakis N, Laubner K, Keck T, Steffl D, Lausch M, Meyer PT, Burger D, Csanadi A, Seufert J. Ectopic ACTH-syndrome due to a neuroendocrine tumour of the appendix. Exp Clin Endocrinol Diabetes. 2011 Oct; 119(9):525-9. PMID: 22006180.
    Citations: 3     Fields:    Translation:Humans
  24. Niu X, Perakakis N, Laubner K, Limbert C, Stahl T, Brendel MD, Bretzel RG, Seufert J, Päth G. Human Krüppel-like factor 11 inhibits human proinsulin promoter activity in pancreatic beta cells. Diabetologia. 2007 Sep; 50(9):2031. PMID: 29167947.
    Citations:    
  25. Niu X, Perakakis N, Laubner K, Limbert C, Stahl T, Brendel MD, Bretzel RG, Seufert J, Päth G. Human Krüppel-like factor 11 inhibits human proinsulin promoter activity in pancreatic beta cells. Diabetologia. 2007 Jul; 50(7):1433-41. PMID: 17479246.
    Citations: 4     Fields:    Translation:HumansCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.