Harvard Catalyst Profiles

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Wenliang Pan, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Scherlinger M, Pan W, Hisada R, Boulougoura A, Yoshida N, Vukelic M, Umeda M, Krishfield S, Tsokos MG, Tsokos GC. Phosphofructokinase P fine-tunes T regulatory cell metabolism, function, and stability in systemic autoimmunity. Sci Adv. 2022 12 02; 8(48):eadc9657. PMID: 36449620; PMCID: PMC9710877.
    Citations:    Fields:    Translation:AnimalsCells
  2. Pan W, Scherlinger M, Yoshida N, Tsokos MG, Tsokos GC. PPP2R2D Suppresses Effector T Cell Exhaustion and Regulatory T Cell Expansion and Inhibits Tumor Growth in Melanoma. J Immunol. 2022 08 01; 209(3):621-628. PMID: 35831019; PMCID: PMC9339485.
    Citations:    Fields:    
  3. Pan W, Nagpal K, Suárez-Fueyo A, Ferretti A, Yoshida N, Tsokos MG, Tsokos GC. The Regulatory Subunit PPP2R2A of PP2A Enhances Th1 and Th17 Differentiation through Activation of the GEF-H1/RhoA/ROCK Signaling Pathway. J Immunol. 2021 04 15; 206(8):1719-1728. PMID: 33762326; PMCID: PMC8026731.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  4. Pan W, Sharabi A, Ferretti A, Zhang Y, Burbano C, Yoshida N, Tsokos MG, Tsokos GC. PPP2R2D suppresses IL-2 production and Treg function. JCI Insight. 2020 10 02; 5(19). PMID: 32897879.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  5. Meidan E, Li H, Pan W, Kono M, Yu S, Kyttaris VC, Ioannidis C, Rodriguez Rodriguez N, Crispin JC, Apostolidis SA, Lee P, Manis J, Sharabi A, Tsokos MG, Tsokos GC. Serine/threonine phosphatase PP2A is essential for optimal B cell function. JCI Insight. 2020 03 12; 5(5). PMID: 32161189.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  6. Kono M, Maeda K, Stocton-Gavanescu I, Pan W, Umeda M, Katsuyama E, Burbano C, Orite SYK, Vukelic M, Tsokos MG, Yoshida N, Tsokos GC. Pyruvate kinase M2 is requisite for Th1 and Th17 differentiation. JCI Insight. 2019 06 20; 4(12). PMID: 31217348.
    Citations: 27     Fields:    Translation:AnimalsCells
  7. Sharabi A, Li H, Kasper IR, Pan W, Meidan E, Tsokos MG, Moulton VR, Tsokos GC. PP2A enables IL-2 signaling by preserving IL-2Rß chain expression during Treg development. JCI Insight. 2019 03 26; 5. PMID: 30912768.
    Citations: 3     Fields:    Translation:AnimalsCells
  8. Pan WL, Wang Y, Hao Y, Wong JH, Chan WC, Wan DC, Ng TB. Overexpression of CXCR4 synergizes with LL-37 in the metastasis of breast cancer cells. Biochim Biophys Acta Mol Basis Dis. 2018 11; 1864(11):3837-3846. PMID: 30251699.
    Citations: 5     Fields:    Translation:HumansCells
  9. Kono M, Yoshida N, Maeda K, Skinner NE, Pan W, Kyttaris VC, Tsokos MG, Tsokos GC. Pyruvate dehydrogenase phosphatase catalytic subunit 2 limits Th17 differentiation. Proc Natl Acad Sci U S A. 2018 09 11; 115(37):9288-9293. PMID: 30150402; PMCID: PMC6140513.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  10. Ng TB, Cheung RCF, Wong JH, Chan YS, Dan X, Pan W, Wang H, Guan S, Chan K, Ye X, Liu F, Xia L, Chan WY. Fungal proteinaceous compounds with multiple biological activities. Appl Microbiol Biotechnol. 2016 Aug; 100(15):6601-6617. PMID: 27338574.
    Citations: 4     Fields:    Translation:Animals
  11. Pan WL, Ng TB. A dimeric Phaseolus coccineus lectin with anti-oxidative, anti-proliferative and cytokine-inducing activities. Int J Biol Macromol. 2015 Nov; 81:960-6. PMID: 26410813.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  12. Akkouh O, Ng TB, Cheung RC, Wong JH, Pan W, Ng CC, Sha O, Shaw PC, Chan WY. Biological activities of ribosome-inactivating proteins and their possible applications as antimicrobial, anticancer, and anti-pest agents and in neuroscience research. Appl Microbiol Biotechnol. 2015 Dec; 99(23):9847-63. PMID: 26394859.
    Citations: 9     Fields:    Translation:HumansAnimals
  13. Cheung RC, Wong JH, Pan W, Chan YS, Yin C, Dan X, Ng TB. Marine lectins and their medicinal applications. Appl Microbiol Biotechnol. 2015 May; 99(9):3755-73. PMID: 25794876; PMCID: PMC7080081.
    Citations: 28     Fields:    Translation:HumansAnimals
  14. Akkouh O, Ng TB, Singh SS, Yin C, Dan X, Chan YS, Pan W, Cheung RC. Lectins with anti-HIV activity: a review. Molecules. 2015 Jan 06; 20(1):648-68. PMID: 25569520; PMCID: PMC6272367.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  15. Singh SS, Wang H, Chan YS, Pan W, Dan X, Yin CM, Akkouh O, Ng TB. Lectins from edible mushrooms. Molecules. 2014 Dec 31; 20(1):446-69. PMID: 25558856; PMCID: PMC6272671.
    Citations: 11     Fields:    Translation:AnimalsCells
  16. Wang Y, Liang WC, Pan WL, Law WK, Hu JS, Ip DT, Waye MM, Ng TB, Wan DC. Silibinin, a novel chemokine receptor type 4 antagonist, inhibits chemokine ligand 12-induced migration in breast cancer cells. Phytomedicine. 2014 Sep 25; 21(11):1310-7. PMID: 25172795.
    Citations: 10     Fields:    Translation:HumansCells
  17. Pan WL, Wong JH, Fang EF, Chan YS, Ng TB, Cheung RC. Preferential cytotoxicity of the type I ribosome inactivating protein alpha-momorcharin on human nasopharyngeal carcinoma cells under normoxia and hypoxia. Biochem Pharmacol. 2014 Jun 01; 89(3):329-39. PMID: 24637239.
    Citations: 19     Fields:    Translation:HumansCells
  18. Cheung RC, Wong JH, Pan WL, Chan YS, Yin CM, Dan XL, Wang HX, Fang EF, Lam SK, Ngai PH, Xia LX, Liu F, Ye XY, Zhang GQ, Liu QH, Sha O, Lin P, Ki C, Bekhit AA, Bekhit Ael-D, Wan DC, Ye XJ, Xia J, Ng TB. Antifungal and antiviral products of marine organisms. Appl Microbiol Biotechnol. 2014 Apr; 98(8):3475-94. PMID: 24562325.
    Citations: 26     Fields:    
  19. Wang Y, Pan WL, Liang WC, Law WK, Tsz-Ming Ip D, Ng TB, Miu-Yee Waye M, Chi-Cheong Wan D. Acetylshikonin, a Novel AChE Inhibitor, Inhibits Apoptosis via Upregulation of Heme Oxygenase-1 Expression in SH-SY5Y Cells. Evid Based Complement Alternat Med. 2013; 2013:937370. PMID: 24302971.
    Citations: 7     
  20. Ang AS, Cheung RC, Dan X, Chan YS, Pan W, Ng TB. Purification and characterization of a glucosamine-binding antifungal lectin from Phaseolus vulgaris cv. Chinese pinto beans with antiproliferative activity towards nasopharyngeal carcinoma cells. Appl Biochem Biotechnol. 2014 Jan; 172(2):672-86. PMID: 24114321.
    Citations: 14     Fields:    Translation:AnimalsCells
  21. Chan YS, Wong JH, Fang EF, Pan W, Ng TB. A hemagglutinin from northeast red beans with immunomodulatory activity and anti-proliferative and apoptosis-inducing activities toward tumor cells. Protein Pept Lett. 2013 Oct; 20(10):1159-69. PMID: 23514011.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  22. Cheung RC, Leung HH, Pan WL, Ng TB. A calcium ion-dependent dimeric bean lectin with antiproliferative activity toward human breast cancer MCF-7 cells. Protein J. 2013 Mar; 32(3):208-15. PMID: 23475505.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  23. Pan WL, Wong JH, Fang EF, Chan YS, Ye XJ, Ng TB. Differential inhibitory potencies and mechanisms of the type I ribosome inactivating protein marmorin on estrogen receptor (ER)-positive and ER-negative breast cancer cells. Biochim Biophys Acta. 2013 May; 1833(5):987-96. PMID: 23274857.
    Citations: 5     Fields:    Translation:HumansCells
  24. Fang EF, Zhang CZ, Zhang L, Wong JH, Chan YS, Pan WL, Dan XL, Yin CM, Cho CH, Ng TB. Trichosanthin inhibits breast cancer cell proliferation in both cell lines and nude mice by promotion of apoptosis. PLoS One. 2012; 7(9):e41592. PMID: 22957017.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  25. Ng TB, Cheung RC, Ye Xj, Fang EF, Chan YS, Pan WL, Dan XL, Yin CM, Lam SK, Lin P, Ngai PH, Xia LX, Liu F, Ye XY, Wang HX, Wong JH. Pharmacotherapy approaches to antifungal prophylaxis. Expert Opin Pharmacother. 2012 Aug; 13(12):1695-705. PMID: 22716311.
    Citations: 2     Fields:    Translation:Humans
  26. Chan YS, Wong JH, Fang EF, Pan W, Ng TB. Isolation of a glucosamine binding leguminous lectin with mitogenic activity towards splenocytes and anti-proliferative activity towards tumor cells. PLoS One. 2012; 7(6):e38961. PMID: 22720002.
    Citations: 12     Fields:    Translation:AnimalsCells
  27. Chan YS, Wong JH, Fang EF, Pan WL, Ng TB. An antifungal peptide from Phaseolus vulgaris cv. brown kidney bean. Acta Biochim Biophys Sin (Shanghai). 2012 Apr; 44(4):307-15. PMID: 22321825.
    Citations: 5     Fields:    Translation:AnimalsCells
  28. Fang EF, Bah CS, Wong JH, Pan WL, Chan YS, Ye XJ, Ng TB. A potential human hepatocellular carcinoma inhibitor from Bauhinia purpurea L. seeds: from purification to mechanism exploration. Arch Toxicol. 2012 Feb; 86(2):293-304. PMID: 21969071.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  29. Fang EF, Zhang CZ, Ng TB, Wong JH, Pan WL, Ye XJ, Chan YS, Fong WP. Momordica Charantia lectin, a type II ribosome inactivating protein, exhibits antitumor activity toward human nasopharyngeal carcinoma cells in vitro and in vivo. Cancer Prev Res (Phila). 2012 Jan; 5(1):109-21. PMID: 21933914.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  30. Fang EF, Pan WL, Wong JH, Chan YS, Ye XJ, Ng TB. A new Phaseolus vulgaris lectin induces selective toxicity on human liver carcinoma Hep G2 cells. Arch Toxicol. 2011 Dec; 85(12):1551-63. PMID: 21445585.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  31. Ng TB, Ye XJ, Wong JH, Fang EF, Chan YS, Pan W, Ye XY, Sze SC, Zhang KY, Liu F, Wang HX. Glyceollin, a soybean phytoalexin with medicinal properties. Appl Microbiol Biotechnol. 2011 Apr; 90(1):59-68. PMID: 21336922.
    Citations: 13     Fields:    Translation:HumansAnimals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.