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profileTimothy Alan Springer, Ph.D.

TitleLatham Family Professor of Biological Chemistry and Molecular Pharmacology
InstitutionImmune Disease Institute
DepartmentBiological Chemistry & Molecular Pharmacology
AddressChildren's Hospital
Program in Cellular and Molecular Medicine, Rm. 3103
3 Blackfan Circle
Boston MA 02115
Phone617/713-8200
Fax617/713-8232
vCardDownload vCard (login for email)

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01CA210920     (SPRINGER, TIMOTHY A)Jul 1, 2016 - Jun 30, 2021
NIH/NCI
Structural mechanisms underlying latency and activation of GDF8
Role: Principal Investigator

R01HL131729     (SPRINGER, TIMOTHY A)Apr 20, 2016 - Mar 31, 2020
NIH/NHLBI
Structures and Conformational Equilibria of Integrin alpha5 beta1
Role: Principal Investigator

R01AR067288     (SPRINGER, TIMOTHY A)Jul 7, 2015 - Jun 30, 2020
NIH/NIAMS
TGF-beta latency and activation
Role: Principal Investigator

R01AI095686     (SPRINGER, TIMOTHY A)Feb 1, 2012 - Jan 31, 2017
NIH/NIAID
Structural Vaccinology of the Malaria Sporozoite Surface Sheath
Role: Principal Investigator

P01HL103526     (SPRINGER, TIMOTHY A)Aug 20, 2011 - Jun 30, 2016
NIH/NHLBI
MULTIDISCIPLINARY STRUCTURES AT VASCULAR CELL SURFACES
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Kotecha A, Wang Q, Dong X, Ilca SL, Ondiviela M, Zihe R, Seago J, Charleston B, Fry EE, Abrescia NGA, Springer TA, Huiskonen JT, Stuart DI. Rules of engagement between avß6 integrin and foot-and-mouth disease virus. Nat Commun. 2017 May 23; 8:15408. PMID: 28534487.
    View in: PubMed
  2. Wang J, Dong X, Zhao B, Li J, Lu C, Springer TA. Atypical interactions of integrin aVß8 with pro-TGF-ß1. Proc Natl Acad Sci U S A. 2017 May 23; 114(21):E4168-E4174. PMID: 28484027.
    View in: PubMed
  3. Li J, Springer TA. Integrin extension enables ultrasensitive regulation by cytoskeletal force. Proc Natl Acad Sci U S A. 2017 May 02; 114(18):4685-4690. PMID: 28416675.
    View in: PubMed
  4. Xu S, Wang J, Wang JH, Springer TA. Distinct recognition of complement iC3b by integrins aXß2 and aMß2. Proc Natl Acad Sci U S A. 2017 Mar 28; 114(13):3403-3408. PMID: 28292891.
    View in: PubMed
  5. Samy KP, Anderson DJ, Lo DJ, Mulvihill MS, Song M, Farris AB, Parker BS, MacDonald AL, Lu C, Springer TA, Kachlany SC, Reimann KA, How T, Leopardi FV, Franke KS, Williams KD, Collins BH, Kirk AD. Selective Targeting of High-Affinity LFA-1 Does Not Augment Costimulation Blockade in a Nonhuman Primate Renal Transplantation Model. Am J Transplant. 2017 May; 17(5):1193-1203. PMID: 27888551.
    View in: PubMed
  6. Gansner JM, Leung AD, Superdock M, Blair MC, Ammerman MB, Durand EM, Barut B, Handin RI, Stachura DL, Lu C, Springer TA, Zon LI. Sorting zebrafish thrombocyte lineage cells with a Cd41 monoclonal antibody enriches hematopoietic stem cell activity. Blood. 2017 Mar 09; 129(10):1394-1397. PMID: 28126924.
    View in: PubMed
  7. Dong X, Zhao B, Iacob RE, Zhu J, Koksal AC, Lu C, Engen JR, Springer TA. Force interacts with macromolecular structure in activation of TGF-ß. Nature. 2017 02 02; 542(7639):55-59. PMID: 28117447.
    View in: PubMed
  8. Li J, Su Y, Xia W, Qin Y, Humphries MJ, Vestweber D, Cabañas C, Lu C, Springer TA. Conformational equilibria and intrinsic affinities define integrin activation. EMBO J. 2017 Mar 01; 36(5):629-645. PMID: 28122868.
    View in: PubMed
  9. Nordenfelt P, Elliott HL, Springer TA. Coordinated integrin activation by actin-dependent force during T-cell migration. Nat Commun. 2016 Oct 10; 7:13119. PMID: 27721490.
    View in: PubMed
  10. Su Y, Xia W, Li J, Walz T, Humphries MJ, Vestweber D, Cabañas C, Lu C, Springer TA. Relating conformation to function in integrin a5ß1. Proc Natl Acad Sci U S A. 2016 07 05; 113(27):E3872-81. PMID: 27317747; PMCID: PMC4941492 [Available on 01/05/17].
  11. Swearingen KE, Lindner SE, Shi L, Shears MJ, Harupa A, Hopp CS, Vaughan AM, Springer TA, Moritz RL, Kappe SH, Sinnis P. Interrogating the Plasmodium Sporozoite Surface: Identification of Surface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP by Mass Spectrometry-Based Proteomics. PLoS Pathog. 2016 Apr; 12(4):e1005606. PMID: 27128092; PMCID: PMC4851412.
  12. Sen M, Springer TA. Leukocyte integrin aLß2 headpiece structures: The aI domain, the pocket for the internal ligand, and concerted movements of its loops. Proc Natl Acad Sci U S A. 2016 Mar 15; 113(11):2940-5. PMID: 26936951; PMCID: PMC4801256.
  13. Lin FY, Zhu J, Eng ET, Hudson NE, Springer TA. ß-Subunit Binding Is Sufficient for Ligands to Open the Integrin aIIbß3 Headpiece. J Biol Chem. 2016 Feb 26; 291(9):4537-46. PMID: 26631735; PMCID: PMC4813479.
  14. Gobas FA, Powell DE, Woodburn KB, Springer T, Huggett DB. Bioaccumulation of decamethylpentacyclosiloxane (D5): A review. Environ Toxicol Chem. 2015 Dec; 34(12):2703-14. PMID: 26363134.
    View in: PubMed
  15. Deforche L, Roose E, Vandenbulcke A, Vandeputte N, Feys HB, Springer TA, Mi LZ, Muia J, Sadler JE, Soejima K, Rottensteiner H, Deckmyn H, De Meyer SF, Vanhoorelbeke K. Linker regions and flexibility around the metalloprotease domain account for conformational activation of ADAMTS-13. J Thromb Haemost. 2015 Nov; 13(11):2063-75. PMID: 26391536; PMCID: PMC4778570 [Available on 11/01/16].
  16. Bury L, Falcinelli E, Chiasserini D, Springer TA, Italiano JE, Gresele P. Cytoskeletal perturbation leads to platelet dysfunction and thrombocytopenia in variant forms of Glanzmann thrombasthenia. Haematologica. 2016 Jan; 101(1):46-56. PMID: 26452979; PMCID: PMC4697891.
  17. Zhu J, Zhu J, Bougie DW, Aster RH, Springer TA. Structural basis for quinine-dependent antibody binding to platelet integrin aIIbß3. Blood. 2015 Oct 29; 126(18):2138-45. PMID: 26282540; PMCID: PMC4626254 [Available on 10/29/16].
  18. Kim J, Hudson NE, Springer TA. Force-induced on-rate switching and modulation by mutations in gain-of-function von Willebrand diseases. Proc Natl Acad Sci U S A. 2015 Apr 14; 112(15):4648-53. PMID: 25810255; PMCID: PMC4403213.
  19. Lin L, Liu L, Zhao B, Xie R, Lin W, Li H, Li Y, Shi M, Chen YG, Springer TA, Chen X. Carbon nanotube-assisted optical activation of TGF-ß signalling by near-infrared light. Nat Nanotechnol. 2015 May; 10(5):465-71. PMID: 25775150.
    View in: PubMed
  20. Mi LZ, Brown CT, Gao Y, Tian Y, Le VQ, Walz T, Springer TA. Structure of bone morphogenetic protein 9 procomplex. Proc Natl Acad Sci U S A. 2015 Mar 24; 112(12):3710-5. PMID: 25751889; PMCID: PMC4378411.
  21. Xia W, Springer TA. Metal ion and ligand binding of integrin a5ß1. Proc Natl Acad Sci U S A. 2014 Dec 16; 111(50):17863-8. PMID: 25475857; PMCID: PMC4273411.
  22. Dong X, Hudson NE, Lu C, Springer TA. Structural determinants of integrin ß-subunit specificity for latent TGF-ß. Nat Struct Mol Biol. 2014 Dec; 21(12):1091-6. PMID: 25383667; PMCID: PMC4717663.
  23. Springer TA. von Willebrand factor, Jedi knight of the bloodstream. Blood. 2014 Aug 28; 124(9):1412-25. PMID: 24928861; PMCID: PMC4148764.
  24. Green JW, Springer TA, Saulnier AN, Swintek J. Statistical analysis of histopathological endpoints. Environ Toxicol Chem. 2014 May; 33(5):1108-16. PMID: 24464649.
    View in: PubMed
  25. Song G, Springer TA. Structures of the Toxoplasma gliding motility adhesin. Proc Natl Acad Sci U S A. 2014 Apr 01; 111(13):4862-7. PMID: 24639528; PMCID: PMC3977308.
  26. Kollmann CS, Bai X, Tsai CH, Yang H, Lind KE, Skinner SR, Zhu Z, Israel DI, Cuozzo JW, Morgan BA, Yuki K, Xie C, Springer TA, Shimaoka M, Evindar G. Application of encoded library technology (ELT) to a protein-protein interaction target: discovery of a potent class of integrin lymphocyte function-associated antigen 1 (LFA-1) antagonists. Bioorg Med Chem. 2014 Apr 01; 22(7):2353-65. PMID: 24593905.
    View in: PubMed
  27. Zhou YF, Springer TA. Highly reinforced structure of a C-terminal dimerization domain in von Willebrand factor. Blood. 2014 Mar 20; 123(12):1785-93. PMID: 24394662; PMCID: PMC3962159.
  28. Blenner MA, Dong X, Springer TA. Structural basis of regulation of von Willebrand factor binding to glycoprotein Ib. J Biol Chem. 2014 Feb 28; 289(9):5565-79. PMID: 24391089; PMCID: PMC3937634.
  29. Sen M, Yuki K, Springer TA. An internal ligand-bound, metastable state of a leukocyte integrin, aXß2. J Cell Biol. 2013 Nov 25; 203(4):629-42. PMID: 24385486; PMCID: PMC3840939.
  30. Yu Y, Schürpf T, Springer TA. How natalizumab binds and antagonizes a4 integrins. J Biol Chem. 2013 Nov 08; 288(45):32314-25. PMID: 24047894; PMCID: PMC3820868.
  31. Zhu J, Zhu J, Springer TA. Complete integrin headpiece opening in eight steps. J Cell Biol. 2013 Jun 24; 201(7):1053-68. PMID: 23798730; PMCID: PMC3691460.
  32. Martinelli R, Kamei M, Sage PT, Massol R, Varghese L, Sciuto T, Toporsian M, Dvorak AM, Kirchhausen T, Springer TA, Carman CV. Release of cellular tension signals self-restorative ventral lamellipodia to heal barrier micro-wounds. J Cell Biol. 2013 Apr 29; 201(3):449-65. PMID: 23629967; PMCID: PMC3639391.
  33. Xu AJ, Springer TA. Mechanisms by which von Willebrand disease mutations destabilize the A2 domain. J Biol Chem. 2013 Mar 01; 288(9):6317-24. PMID: 23322777; PMCID: PMC3585066.
  34. Yu Y, Zhu J, Huang PS, Wang JH, Pullen N, Springer TA. Domain 1 of mucosal addressin cell adhesion molecule has an I1-set fold and a flexible integrin-binding loop. J Biol Chem. 2013 Mar 01; 288(9):6284-94. PMID: 23297416; PMCID: PMC3585063.
  35. Green JW, Springer TA, Staveley JP. The drive to ban the NOEC/LOEC in favor of ECx is misguided and misinformed. Integr Environ Assess Manag. 2013 Jan; 9(1):12-6. PMID: 22991182.
    View in: PubMed
  36. Song G, Koksal AC, Lu C, Springer TA. Shape change in the receptor for gliding motility in Plasmodium sporozoites. Proc Natl Acad Sci U S A. 2012 Dec 26; 109(52):21420-5. PMID: 23236185; PMCID: PMC3535621.
  37. Dong X, Mi LZ, Zhu J, Wang W, Hu P, Luo BH, Springer TA. a(V)ß(3) integrin crystal structures and their functional implications. Biochemistry. 2012 Nov 06; 51(44):8814-28. PMID: 23106217; PMCID: PMC3495331.
  38. Lu C, Mi LZ, Schürpf T, Walz T, Springer TA. Mechanisms for kinase-mediated dimerization of the epidermal growth factor receptor. J Biol Chem. 2012 Nov 02; 287(45):38244-53. PMID: 22988250; PMCID: PMC3488093.
  39. Kang S, Kim CU, Gu X, Owens RM, van Rijn SJ, Boonyaleepun V, Mao Y, Springer TA, Jin MM. Complex structure of engineered modular domains defining molecular interaction between ICAM-1 and integrin LFA-1. PLoS One. 2012; 7(8):e44124. PMID: 22956999; PMCID: PMC3431320.
  40. Schürpf T, Chen Q, Liu JH, Wang R, Springer TA, Wang JH. The RGD finger of Del-1 is a unique structural feature critical for integrin binding. FASEB J. 2012 Aug; 26(8):3412-20. PMID: 22601780; PMCID: PMC3405271.
  41. Doud MB, Koksal AC, Mi LZ, Song G, Lu C, Springer TA. Unexpected fold in the circumsporozoite protein target of malaria vaccines. Proc Natl Acad Sci U S A. 2012 May 15; 109(20):7817-22. PMID: 22547819; PMCID: PMC3356675.
  42. Zhou YF, Eng ET, Zhu J, Lu C, Walz T, Springer TA. Sequence and structure relationships within von Willebrand factor. Blood. 2012 Jul 12; 120(2):449-58. PMID: 22490677; PMCID: PMC3398765.
  43. Sage PT, Varghese LM, Martinelli R, Sciuto TE, Kamei M, Dvorak AM, Springer TA, Sharpe AH, Carman CV. Antigen recognition is facilitated by invadosome-like protrusions formed by memory/effector T cells. J Immunol. 2012 Apr 15; 188(8):3686-99. PMID: 22442443; PMCID: PMC3324627.
  44. Zhu J, Choi WS, McCoy JG, Negri A, Zhu J, Naini S, Li J, Shen M, Huang W, Bougie D, Rasmussen M, Aster R, Thomas CJ, Filizola M, Springer TA, Coller BS. Structure-guided design of a high-affinity platelet integrin aIIbß3 receptor antagonist that disrupts Mg²? binding to the MIDAS. Sci Transl Med. 2012 Mar 14; 4(125):125ra32. PMID: 22422993; PMCID: PMC3390238.
  45. Chen X, Yu Y, Mi LZ, Walz T, Springer TA. Molecular basis for complement recognition by integrin aXß2. Proc Natl Acad Sci U S A. 2012 Mar 20; 109(12):4586-91. PMID: 22393018; PMCID: PMC3311339.
  46. Xu AJ, Springer TA. Calcium stabilizes the von Willebrand factor A2 domain by promoting refolding. Proc Natl Acad Sci U S A. 2012 Mar 06; 109(10):3742-7. PMID: 22357761; PMCID: PMC3309790.
  47. Wang R, Zhu J, Dong X, Shi M, Lu C, Springer TA. GARP regulates the bioavailability and activation of TGFß. Mol Biol Cell. 2012 Mar; 23(6):1129-39. PMID: 22278742; PMCID: PMC3302739.
  48. Yu Y, Zhu J, Mi LZ, Walz T, Sun H, Chen J, Springer TA. Structural specializations of a(4)ß(7), an integrin that mediates rolling adhesion. J Cell Biol. 2012 Jan 09; 196(1):131-46. PMID: 22232704; PMCID: PMC3255974.
  49. Springer TA, Dustin ML. Integrin inside-out signaling and the immunological synapse. Curr Opin Cell Biol. 2012 Feb; 24(1):107-15. PMID: 22129583; PMCID: PMC3294052.
  50. Holbech H, Kinnberg KL, Brande-Lavridsen N, Bjerregaard P, Petersen GI, Norrgren L, Orn S, Braunbeck T, Baumann L, Bomke C, Dorgerloh M, Bruns E, Ruehl-Fehlert C, Green JW, Springer TA, Gourmelon A. Comparison of zebrafish (Danio rerio) and fathead minnow (Pimephales promelas) as test species in the Fish Sexual Development Test (FSDT). Comp Biochem Physiol C Toxicol Pharmacol. 2012 Mar; 155(2):407-15. PMID: 22115822.
    View in: PubMed
  51. Weitz-Schmidt G, Schürpf T, Springer TA. The C-terminal aI domain linker as a critical structural element in the conformational activation of aI integrins. J Biol Chem. 2011 Dec 09; 286(49):42115-22. PMID: 21965670; PMCID: PMC3234956.
  52. Schürpf T, Springer TA. Regulation of integrin affinity on cell surfaces. EMBO J. 2011 Sep 23; 30(23):4712-27. PMID: 21946563; PMCID: PMC3243613.
  53. Zhou YF, Eng ET, Nishida N, Lu C, Walz T, Springer TA. A pH-regulated dimeric bouquet in the structure of von Willebrand factor. EMBO J. 2011 Aug 19; 30(19):4098-111. PMID: 21857647; PMCID: PMC3209782.
  54. Eng ET, Smagghe BJ, Walz T, Springer TA. Intact alphaIIbbeta3 integrin is extended after activation as measured by solution X-ray scattering and electron microscopy. J Biol Chem. 2011 Oct 07; 286(40):35218-26. PMID: 21832081; PMCID: PMC3186426.
  55. Mi LZ, Lu C, Li Z, Nishida N, Walz T, Springer TA. Simultaneous visualization of the extracellular and cytoplasmic domains of the epidermal growth factor receptor. Nat Struct Mol Biol. 2011 Aug 07; 18(9):984-9. PMID: 21822280; PMCID: PMC4117315.
  56. Springer TA. Biology and physics of von Willebrand factor concatamers. J Thromb Haemost. 2011 Jul; 9 Suppl 1:130-43. PMID: 21781248; PMCID: PMC4117350.
  57. Shi M, Zhu J, Wang R, Chen X, Mi L, Walz T, Springer TA. Latent TGF-ß structure and activation. Nature. 2011 Jun 15; 474(7351):343-9. PMID: 21677751; PMCID: PMC4717672.
  58. Rothlein R, Dustin ML, Marlin SD, Springer TA. A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1. J. Immunol. 1986. 137: 1270-1274. J Immunol. 2011 May 01; 186(9):5034-8. PMID: 21505215.
    View in: PubMed
  59. Dustin ML, Rothlein R, Bhan AK, Dinarello CA, Springer TA. Induction by IL 1 and interferon-?: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J. Immunol. 1986. 137: 245-254. J Immunol. 2011 May 01; 186(9):5024-33. PMID: 21505214.
    View in: PubMed
  60. Zhou M, Dong X, Baldauf C, Chen H, Zhou Y, Springer TA, Luo X, Zhong C, Gräter F, Ding J. A novel calcium-binding site of von Willebrand factor A2 domain regulates its cleavage by ADAMTS13. Blood. 2011 Apr 28; 117(17):4623-31. PMID: 21385852.
    View in: PubMed
  61. Rufli H, Springer TA. Can we reduce the number of fish in the OECD acute toxicity test? Environ Toxicol Chem. 2011 Apr; 30(4):1006-11. PMID: 21309020.
    View in: PubMed
  62. Pan Y, Zhang K, Qi J, Yue J, Springer TA, Chen J. Cation-pi interaction regulates ligand-binding affinity and signaling of integrin alpha4beta7. Proc Natl Acad Sci U S A. 2010 Dec 14; 107(50):21388-93. PMID: 21098296; PMCID: PMC3003088.
  63. Wang W, Zhu J, Springer TA, Luo BH. Tests of integrin transmembrane domain homo-oligomerization during integrin ligand binding and signaling. J Biol Chem. 2011 Jan 21; 286(3):1860-7. PMID: 21081497; PMCID: PMC3023481.
  64. Lu C, Mi LZ, Grey MJ, Zhu J, Graef E, Yokoyama S, Springer TA. Structural evidence for loose linkage between ligand binding and kinase activation in the epidermal growth factor receptor. Mol Cell Biol. 2010 Nov; 30(22):5432-43. PMID: 20837704; PMCID: PMC2976375.
  65. Kim J, Zhang CZ, Zhang X, Springer TA. A mechanically stabilized receptor-ligand flex-bond important in the vasculature. Nature. 2010 Aug 19; 466(7309):992-5. PMID: 20725043; PMCID: PMC4117310.
  66. Zhu J, Zhu J, Negri A, Provasi D, Filizola M, Coller BS, Springer TA. Closed headpiece of integrin aIIbß3 and its complex with an aIIbß3-specific antagonist that does not induce opening. Blood. 2010 Dec 02; 116(23):5050-9. PMID: 20679525; PMCID: PMC3012599.
  67. Chen X, Xie C, Nishida N, Li Z, Walz T, Springer TA. Requirement of open headpiece conformation for activation of leukocyte integrin alphaXbeta2. Proc Natl Acad Sci U S A. 2010 Aug 17; 107(33):14727-32. PMID: 20679211; PMCID: PMC2930457.
  68. Smagghe BJ, Huang PS, Ban YE, Baker D, Springer TA. Modulation of integrin activation by an entropic spring in the {beta}-knee. J Biol Chem. 2010 Oct 22; 285(43):32954-66. PMID: 20670939; PMCID: PMC2963379.
  69. Wolf JC, Lutz I, Kloas W, Springer TA, Holden LR, Krueger HO, Hosmer AJ. Effects of 17 beta-estradiol exposure on Xenopus laevis gonadal histopathology. Environ Toxicol Chem. 2010 May; 29(5):1091-105. PMID: 20821545.
    View in: PubMed
  70. Owens RM, Gu X, Shin M, Springer TA, Jin MM. Engineering of single Ig superfamily domain of intercellular adhesion molecule 1 (ICAM-1) for native fold and function. J Biol Chem. 2010 May 21; 285(21):15906-15. PMID: 20304924; PMCID: PMC2871458.
  71. Xie C, Zhu J, Chen X, Mi L, Nishida N, Springer TA. Structure of an integrin with an alphaI domain, complement receptor type 4. EMBO J. 2010 Feb 03; 29(3):666-79. PMID: 20033057; PMCID: PMC2830704.
  72. Zhang H, Liu JH, Yang W, Springer T, Shimaoka M, Wang JH. Structural basis of activation-dependent binding of ligand-mimetic antibody AL-57 to integrin LFA-1. Proc Natl Acad Sci U S A. 2009 Oct 27; 106(43):18345-50. PMID: 19805116; PMCID: PMC2775275.
  73. Zhang X, Halvorsen K, Zhang CZ, Wong WP, Springer TA. Mechanoenzymatic cleavage of the ultralarge vascular protein von Willebrand factor. Science. 2009 Jun 05; 324(5932):1330-4. PMID: 19498171; PMCID: PMC2753189.
  74. Zhang Q, Zhou YF, Zhang CZ, Zhang X, Lu C, Springer TA. Structural specializations of A2, a force-sensing domain in the ultralarge vascular protein von Willebrand factor. Proc Natl Acad Sci U S A. 2009 Jun 09; 106(23):9226-31. PMID: 19470641; PMCID: PMC2695068.
  75. Zhu J, Luo BH, Barth P, Schonbrun J, Baker D, Springer TA. The structure of a receptor with two associating transmembrane domains on the cell surface: integrin alphaIIbbeta3. Mol Cell. 2009 Apr 24; 34(2):234-49. PMID: 19394300; PMCID: PMC2694939.
  76. Kloas W, Lutz I, Urbatzka R, Springer T, Krueger H, Wolf J, Holden L, Hosmer A. Does atrazine affect larval development and sexual differentiation of South African clawed frogs? Ann N Y Acad Sci. 2009 Apr; 1163:437-40. PMID: 19456380.
    View in: PubMed
  77. Vanhoorelbeke K, De Meyer SF, Pareyn I, Melchior C, Plançon S, Margue C, Pradier O, Fondu P, Kieffer N, Springer TA, Deckmyn H. The novel S527F mutation in the integrin beta3 chain induces a high affinity alphaIIbbeta3 receptor by hindering adoption of the bent conformation. J Biol Chem. 2009 May 29; 284(22):14914-20. PMID: 19329429; PMCID: PMC2685673.
  78. Waldron TT, Springer TA. Transmission of allostery through the lectin domain in selectin-mediated cell adhesion. Proc Natl Acad Sci U S A. 2009 Jan 06; 106(1):85-90. PMID: 19118202; PMCID: PMC2629216.
  79. Springer TA. Structural basis for selectin mechanochemistry. Proc Natl Acad Sci U S A. 2009 Jan 06; 106(1):91-6. PMID: 19118197; PMCID: PMC2629181.
  80. Zhu J, Luo BH, Xiao T, Zhang C, Nishida N, Springer TA. Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces. Mol Cell. 2008 Dec 26; 32(6):849-61. PMID: 19111664; PMCID: PMC2758073.
  81. Luo BH, Karanicolas J, Harmacek LD, Baker D, Springer TA. Rationally designed integrin beta3 mutants stabilized in the high affinity conformation. J Biol Chem. 2009 Feb 06; 284(6):3917-24. PMID: 19019827; PMCID: PMC2635054.
  82. Kloas W, Lutz I, Springer T, Krueger H, Wolf J, Holden L, Hosmer A. Does atrazine influence larval development and sexual differentiation in Xenopus laevis? Toxicol Sci. 2009 Feb; 107(2):376-84. PMID: 19008211; PMCID: PMC2639758.
  83. Springer TA, Guiney PD, Krueger HO, Jaber MJ. Assessment of an approach to estimating aquatic bioconcentration factors using reduced sampling. Environ Toxicol Chem. 2008 Nov; 27(11):2271-80. PMID: 18522474.
    View in: PubMed
  84. Mi LZ, Grey MJ, Nishida N, Walz T, Lu C, Springer TA. Functional and structural stability of the epidermal growth factor receptor in detergent micelles and phospholipid nanodiscs. Biochemistry. 2008 Sep 30; 47(39):10314-23. PMID: 18771282; PMCID: PMC2658769.
  85. Springer TA, Zhu J, Xiao T. Structural basis for distinctive recognition of fibrinogen gammaC peptide by the platelet integrin alphaIIbbeta3. J Cell Biol. 2008 Aug 25; 182(4):791-800. PMID: 18710925; PMCID: PMC2518716.
  86. Zhang H, Casasnovas JM, Jin M, Liu JH, Gahmberg CG, Springer TA, Wang JH. An unusual allosteric mobility of the C-terminal helix of a high-affinity alphaL integrin I domain variant bound to ICAM-5. Mol Cell. 2008 Aug 08; 31(3):432-7. PMID: 18691975; PMCID: PMC2603608.
  87. Carman CV, Springer TA. Trans-cellular migration: cell-cell contacts get intimate. Curr Opin Cell Biol. 2008 Oct; 20(5):533-40. PMID: 18595683; PMCID: PMC2811962.
  88. Lutz I, Kloas W, Springer TA, Holden LR, Wolf JC, Krueger HO, Hosmer AJ. Development, standardization and refinement of procedures for evaluating effects of endocrine active compounds on development and sexual differentiation of Xenopus laevis. Anal Bioanal Chem. 2008 Apr; 390(8):2031-48. PMID: 18327572; PMCID: PMC2287204.
  89. Morin NA, Oakes PW, Hyun YM, Lee D, Chin YE, Chin EY, King MR, Springer TA, Shimaoka M, Tang JX, Reichner JS, Kim M. Nonmuscle myosin heavy chain IIA mediates integrin LFA-1 de-adhesion during T lymphocyte migration. J Exp Med. 2008 Jan 21; 205(1):195-205. PMID: 18195072; PMCID: PMC2234359.
  90. Chen X, Kim TD, Carman CV, Mi LZ, Song G, Springer TA. Structural plasticity in Ig superfamily domain 4 of ICAM-1 mediates cell surface dimerization. Proc Natl Acad Sci U S A. 2007 Sep 25; 104(39):15358-63. PMID: 17881562; PMCID: PMC2000496.
  91. Bonasio R, Carman CV, Kim E, Sage PT, Love KR, Mempel TR, Springer TA, von Andrian UH. Specific and covalent labeling of a membrane protein with organic fluorochromes and quantum dots. Proc Natl Acad Sci U S A. 2007 Sep 11; 104(37):14753-8. PMID: 17785425; PMCID: PMC1976196.
  92. Vorup-Jensen T, Chi L, Gjelstrup LC, Jensen UB, Jewett CA, Xie C, Shimaoka M, Linhardt RJ, Springer TA. Binding between the integrin alphaXbeta2 (CD11c/CD18) and heparin. J Biol Chem. 2007 Oct 19; 282(42):30869-77. PMID: 17699512; PMCID: PMC4142650.
  93. Vorup-Jensen T, Waldron TT, Astrof N, Shimaoka M, Springer TA. The connection between metal ion affinity and ligand affinity in integrin I domains. Biochim Biophys Acta. 2007 Sep; 1774(9):1148-55. PMID: 17702677; PMCID: PMC2040231.
  94. Zhu J, Carman CV, Kim M, Shimaoka M, Springer TA, Luo BH. Requirement of alpha and beta subunit transmembrane helix separation for integrin outside-in signaling. Blood. 2007 Oct 01; 110(7):2475-83. PMID: 17615290; PMCID: PMC1988953.
  95. Carman CV, Sage PT, Sciuto TE, de la Fuente MA, Geha RS, Ochs HD, Dvorak HF, Dvorak AM, Springer TA. Transcellular diapedesis is initiated by invasive podosomes. Immunity. 2007 Jun; 26(6):784-97. PMID: 17570692; PMCID: PMC2094044.
  96. Zhu J, Boylan B, Luo BH, Newman PJ, Springer TA. Tests of the extension and deadbolt models of integrin activation. J Biol Chem. 2007 Apr 20; 282(16):11914-20. PMID: 17301049; PMCID: PMC1952534.
  97. Luo BH, Carman CV, Springer TA. Structural basis of integrin regulation and signaling. Annu Rev Immunol. 2007; 25:619-47. PMID: 17201681; PMCID: PMC1952532.
  98. Astrof NS, Salas A, Shimaoka M, Chen J, Springer TA. Importance of force linkage in mechanochemistry of adhesion receptors. Biochemistry. 2006 Dec 19; 45(50):15020-8. PMID: 17154539; PMCID: PMC1766327.
  99. Nishida N, Walz T, Springer TA. Structural transitions of complement component C3 and its activation products. Proc Natl Acad Sci U S A. 2006 Dec 26; 103(52):19737-42. PMID: 17172439; PMCID: PMC1750921.
  100. Springer TA. Complement and the multifaceted functions of VWA and integrin I domains. Structure. 2006 Nov; 14(11):1611-6. PMID: 17098186; PMCID: PMC1712385.
  101. Yang W, Carman CV, Kim M, Salas A, Shimaoka M, Springer TA. A small molecule agonist of an integrin, alphaLbeta2. J Biol Chem. 2006 Dec 08; 281(49):37904-12. PMID: 17023419; PMCID: PMC1764823.
  102. Nishida N, Xie C, Shimaoka M, Cheng Y, Walz T, Springer TA. Activation of leukocyte beta2 integrins by conversion from bent to extended conformations. Immunity. 2006 Oct; 25(4):583-94. PMID: 17045822.
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  103. Swers JS, Widom A, Phan U, Springer TA, Wittrup KD. A high affinity human antibody antagonist of P-selectin mediated rolling. Biochem Biophys Res Commun. 2006 Nov 24; 350(3):508-13. PMID: 17027652.
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  104. Shimaoka M, Kim M, Cohen EH, Yang W, Astrof N, Peer D, Salas A, Ferrand A, Springer TA. AL-57, a ligand-mimetic antibody to integrin LFA-1, reveals chemokine-induced affinity up-regulation in lymphocytes. Proc Natl Acad Sci U S A. 2006 Sep 19; 103(38):13991-6. PMID: 16963559; PMCID: PMC1599901.
  105. Chen J, Yang W, Kim M, Carman CV, Springer TA. Regulation of outside-in signaling and affinity by the beta2 I domain of integrin alphaLbeta2. Proc Natl Acad Sci U S A. 2006 Aug 29; 103(35):13062-7. PMID: 16920795; PMCID: PMC1559753.
  106. Luo BH, Springer TA. Integrin structures and conformational signaling. Curr Opin Cell Biol. 2006 Oct; 18(5):579-86. PMID: 16904883; PMCID: PMC1618925.
  107. Huang L, Shimaoka M, Rondon IJ, Roy I, Chang Q, Po M, Dransfield DT, Ladner RC, Edge AS, Salas A, Wood CR, Springer TA, Cohen EH. Identification and characterization of a human monoclonal antagonistic antibody AL-57 that preferentially binds the high-affinity form of lymphocyte function-associated antigen-1. J Leukoc Biol. 2006 Oct; 80(4):905-14. PMID: 16888085; PMCID: PMC1712386.
  108. Phan UT, Waldron TT, Springer TA. Remodeling of the lectin-EGF-like domain interface in P- and L-selectin increases adhesiveness and shear resistance under hydrodynamic force. Nat Immunol. 2006 Aug; 7(8):883-9. PMID: 16845394; PMCID: PMC1764822.
  109. Bonifacino JS, Dell'Angelica EC, Springer TA. Immunoprecipitation. Curr Protoc Neurosci. 2006 May; Chapter 5:Unit 5.24. PMID: 18428640.
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  110. Jin M, Song G, Carman CV, Kim YS, Astrof NS, Shimaoka M, Wittrup DK, Springer TA. Directed evolution to probe protein allostery and integrin I domains of 200,000-fold higher affinity. Proc Natl Acad Sci U S A. 2006 Apr 11; 103(15):5758-63. PMID: 16595626; PMCID: PMC1458646.
  111. Salas A, Shimaoka M, Phan U, Kim M, Springer TA. Transition from rolling to firm adhesion can be mimicked by extension of integrin alphaLbeta2 in an intermediate affinity state. J Biol Chem. 2006 Apr 21; 281(16):10876-82. PMID: 16505487; PMCID: PMC1599852.
  112. Song G, Lazar GA, Kortemme T, Shimaoka M, Desjarlais JR, Baker D, Springer TA. Rational design of intercellular adhesion molecule-1 (ICAM-1) variants for antagonizing integrin lymphocyte function-associated antigen-1-dependent adhesion. J Biol Chem. 2006 Feb 24; 281(8):5042-9. PMID: 16354667; PMCID: PMC1455478.
  113. Zhang F, Marcus WD, Goyal NH, Selvaraj P, Springer TA, Zhu C. Two-dimensional kinetics regulation of alphaLbeta2-ICAM-1 interaction by conformational changes of the alphaL-inserted domain. J Biol Chem. 2005 Dec 23; 280(51):42207-18. PMID: 16234238; PMCID: PMC1475765.
  114. Luo BH, Carman CV, Takagi J, Springer TA. Disrupting integrin transmembrane domain heterodimerization increases ligand binding affinity, not valency or clustering. Proc Natl Acad Sci U S A. 2005 Mar 08; 102(10):3679-84. PMID: 15738420; PMCID: PMC553322.
  115. Song G, Yang Y, Liu JH, Casasnovas JM, Shimaoka M, Springer TA, Wang JH. An atomic resolution view of ICAM recognition in a complex between the binding domains of ICAM-3 and integrin alphaLbeta2. Proc Natl Acad Sci U S A. 2005 Mar 01; 102(9):3366-71. PMID: 15728350; PMCID: PMC552929.
  116. Vorup-Jensen T, Carman CV, Shimaoka M, Schuck P, Svitel J, Springer TA. Exposure of acidic residues as a danger signal for recognition of fibrinogen and other macromolecules by integrin alphaXbeta2. Proc Natl Acad Sci U S A. 2005 Feb 01; 102(5):1614-9. PMID: 15665082; PMCID: PMC547869.
  117. Kim M, Carman CV, Yang W, Salas A, Springer TA. The primacy of affinity over clustering in regulation of adhesiveness of the integrin {alpha}L{beta}2. J Cell Biol. 2004 Dec 20; 167(6):1241-53. PMID: 15611342; PMCID: PMC2172602.
  118. Jin M, Andricioaei I, Springer TA. Conversion between three conformational states of integrin I domains with a C-terminal pull spring studied with molecular dynamics. Structure. 2004 Dec; 12(12):2137-47. PMID: 15576028.
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  119. Jiménez D, Roda-Navarro P, Springer TA, Casasnovas JM. Contribution of N-linked glycans to the conformation and function of intercellular adhesion molecules (ICAMs). J Biol Chem. 2005 Feb 18; 280(7):5854-61. PMID: 15545280.
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  120. Carman CV, Springer TA. A transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them. J Cell Biol. 2004 Oct 25; 167(2):377-88. PMID: 15504916; PMCID: PMC2172560.
  121. Xie C, Shimaoka M, Xiao T, Schwab P, Klickstein LB, Springer TA. The integrin alpha-subunit leg extends at a Ca2+-dependent epitope in the thigh/genu interface upon activation. Proc Natl Acad Sci U S A. 2004 Oct 26; 101(43):15422-7. PMID: 15494438; PMCID: PMC524430.
  122. Lafuente EM, van Puijenbroek AA, Krause M, Carman CV, Freeman GJ, Berezovskaya A, Constantine E, Springer TA, Gertler FB, Boussiotis VA. RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion. Dev Cell. 2004 Oct; 7(4):585-95. PMID: 15469846.
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  123. Chen J, Takagi J, Xie C, Xiao T, Luo BH, Springer TA. The relative influence of metal ion binding sites in the I-like domain and the interface with the hybrid domain on rolling and firm adhesion by integrin alpha4beta7. J Biol Chem. 2004 Dec 31; 279(53):55556-61. PMID: 15448154; PMCID: PMC4373085.
  124. Xiao T, Takagi J, Coller BS, Wang JH, Springer TA. Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics. Nature. 2004 Nov 04; 432(7013):59-67. PMID: 15378069; PMCID: PMC4372090.
  125. Lu C, Shimaoka M, Salas A, Springer TA. The binding sites for competitive antagonistic, allosteric antagonistic, and agonistic antibodies to the I domain of integrin LFA-1. J Immunol. 2004 Sep 15; 173(6):3972-8. PMID: 15356146.
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  126. Artoni A, Li J, Mitchell B, Ruan J, Takagi J, Springer TA, French DL, Coller BS. Integrin beta3 regions controlling binding of murine mAb 7E3: implications for the mechanism of integrin alphaIIbbeta3 activation. Proc Natl Acad Sci U S A. 2004 Sep 07; 101(36):13114-20. PMID: 15277669; PMCID: PMC516524.
  127. Luo BH, Springer TA, Takagi J. A specific interface between integrin transmembrane helices and affinity for ligand. PLoS Biol. 2004 Jun; 2(6):e153. PMID: 15208712; PMCID: PMC423134.
  128. Luo BH, Strokovich K, Walz T, Springer TA, Takagi J. Allosteric beta1 integrin antibodies that stabilize the low affinity state by preventing the swing-out of the hybrid domain. J Biol Chem. 2004 Jun 25; 279(26):27466-71. PMID: 15123676.
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  129. Yang Y, Jun CD, Liu JH, Zhang R, Joachimiak A, Springer TA, Wang JH. Structural basis for dimerization of ICAM-1 on the cell surface. Mol Cell. 2004 Apr 23; 14(2):269-76. PMID: 15099525.
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  130. Salas A, Shimaoka M, Kogan AN, Harwood C, von Andrian UH, Springer TA. Rolling adhesion through an extended conformation of integrin alphaLbeta2 and relation to alpha I and beta I-like domain interaction. Immunity. 2004 Apr; 20(4):393-406. PMID: 15084269.
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  131. Culi J, Springer TA, Mann RS. Boca-dependent maturation of beta-propeller/EGF modules in low-density lipoprotein receptor proteins. EMBO J. 2004 Mar 24; 23(6):1372-80. PMID: 15014448; PMCID: PMC381407.
  132. Yang W, Shimaoka M, Chen J, Springer TA. Activation of integrin beta-subunit I-like domains by one-turn C-terminal alpha-helix deletions. Proc Natl Acad Sci U S A. 2004 Feb 24; 101(8):2333-8. PMID: 14983010; PMCID: PMC356951.
  133. Yang W, Shimaoka M, Salas A, Takagi J, Springer TA. Intersubunit signal transmission in integrins by a receptor-like interaction with a pull spring. Proc Natl Acad Sci U S A. 2004 Mar 02; 101(9):2906-11. PMID: 14978279; PMCID: PMC365718.
  134. Shimaoka M, Springer TA. Therapeutic antagonists and the conformational regulation of the beta2 integrins. Curr Top Med Chem. 2004; 4(14):1485-95. PMID: 15544539.
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  135. Springer TA, Wang JH. The three-dimensional structure of integrins and their ligands, and conformational regulation of cell adhesion. Adv Protein Chem. 2004; 68:29-63. PMID: 15500858.
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  136. Luo BH, Takagi J, Springer TA. Locking the beta3 integrin I-like domain into high and low affinity conformations with disulfides. J Biol Chem. 2004 Mar 12; 279(11):10215-21. PMID: 14681220.
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  137. Carman CV, Jun CD, Salas A, Springer TA. Endothelial cells proactively form microvilli-like membrane projections upon intercellular adhesion molecule 1 engagement of leukocyte LFA-1. J Immunol. 2003 Dec 01; 171(11):6135-44. PMID: 14634129.
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  138. Chen J, Salas A, Springer TA. Bistable regulation of integrin adhesiveness by a bipolar metal ion cluster. Nat Struct Biol. 2003 Dec; 10(12):995-1001. PMID: 14608374.
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  139. Carman CV, Springer TA. Integrin avidity regulation: are changes in affinity and conformation underemphasized? Curr Opin Cell Biol. 2003 Oct; 15(5):547-56. PMID: 14519389.
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  140. Kim M, Carman CV, Springer TA. Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins. Science. 2003 Sep 19; 301(5640):1720-5. PMID: 14500982.
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  141. Takagi J, Strokovich K, Springer TA, Walz T. Structure of integrin alpha5beta1 in complex with fibronectin. EMBO J. 2003 Sep 15; 22(18):4607-15. PMID: 12970173; PMCID: PMC212714.
  142. Shimaoka M, Salas A, Yang W, Weitz-Schmidt G, Springer TA. Small molecule integrin antagonists that bind to the beta2 subunit I-like domain and activate signals in one direction and block them in the other. Immunity. 2003 Sep; 19(3):391-402. PMID: 14499114.
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  143. Lehmann JC, Jablonski-Westrich D, Haubold U, Gutierrez-Ramos JC, Springer T, Hamann A. Overlapping and selective roles of endothelial intercellular adhesion molecule-1 (ICAM-1) and ICAM-2 in lymphocyte trafficking. J Immunol. 2003 Sep 01; 171(5):2588-93. PMID: 12928410.
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  144. Shimaoka M, Springer TA. Therapeutic antagonists and conformational regulation of integrin function. Nat Rev Drug Discov. 2003 Sep; 2(9):703-16. PMID: 12951577.
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  145. Takagi J, Yang Y, Liu JH, Wang JH, Springer TA. Complex between nidogen and laminin fragments reveals a paradigmatic beta-propeller interface. Nature. 2003 Aug 21; 424(6951):969-74. PMID: 12931195.
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  146. Tohyama Y, Katagiri K, Pardi R, Lu C, Springer TA, Kinashi T. The critical cytoplasmic regions of the alphaL/beta2 integrin in Rap1-induced adhesion and migration. Mol Biol Cell. 2003 Jun; 14(6):2570-82. PMID: 12808052; PMCID: PMC194904.
  147. Luo BH, Springer TA, Takagi J. Stabilizing the open conformation of the integrin headpiece with a glycan wedge increases affinity for ligand. Proc Natl Acad Sci U S A. 2003 Mar 04; 100(5):2403-8. PMID: 12604783; PMCID: PMC151353.
  148. Luo BH, Springer TA, Takagi J. High affinity ligand binding by integrins does not involve head separation. J Biol Chem. 2003 May 09; 278(19):17185-9. PMID: 12600996.
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  149. Vorup-Jensen T, Ostermeier C, Shimaoka M, Hommel U, Springer TA. Structure and allosteric regulation of the alpha X beta 2 integrin I domain. Proc Natl Acad Sci U S A. 2003 Feb 18; 100(4):1873-8. PMID: 12554829; PMCID: PMC149926.
  150. Shimaoka M, Xiao T, Liu JH, Yang Y, Dong Y, Jun CD, McCormack A, Zhang R, Joachimiak A, Takagi J, Wang JH, Springer TA. Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation. Cell. 2003 Jan 10; 112(1):99-111. PMID: 12526797; PMCID: PMC4372089.
  151. Shimaoka M, Lu C, Salas A, Xiao T, Takagi J, Springer TA. Stabilizing the integrin alpha M inserted domain in alternative conformations with a range of engineered disulfide bonds. Proc Natl Acad Sci U S A. 2002 Dec 24; 99(26):16737-41. PMID: 12466503; PMCID: PMC139213.
  152. Springer TA. Predicted and experimental structures of integrins and beta-propellers. Curr Opin Struct Biol. 2002 Dec; 12(6):802-13. PMID: 12504686.
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  153. Salas A, Shimaoka M, Chen S, Carman CV, Springer T. Transition from rolling to firm adhesion is regulated by the conformation of the I domain of the integrin lymphocyte function-associated antigen-1. J Biol Chem. 2002 Dec 27; 277(52):50255-62. PMID: 12368274.
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  154. Jing H, Takagi J, Liu JH, Lindgren S, Zhang RG, Joachimiak A, Wang JH, Springer TA. Archaeal surface layer proteins contain beta propeller, PKD, and beta helix domains and are related to metazoan cell surface proteins. Structure. 2002 Oct; 10(10):1453-64. PMID: 12377130.
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  155. Springer TA, Chen S, Alon R. Measurement of selectin tether bond lifetimes. Biophys J. 2002 Oct; 83(4):2318-20; author reply 2320-3. PMID: 12371417; PMCID: PMC1302319.
  156. Takagi J, Petre BM, Walz T, Springer TA. Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling. Cell. 2002 Sep 06; 110(5):599-11. PMID: 12230977.
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  157. Takagi J, Springer TA. Integrin activation and structural rearrangement. Immunol Rev. 2002 Aug; 186:141-63. PMID: 12234369.
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  158. Hirose J, Kawashima H, Swope Willis M, Springer TA, Hasegawa H, Yoshie O, Miyasaka M. Chondroitin sulfate B exerts its inhibitory effect on secondary lymphoid tissue chemokine (SLC) by binding to the C-terminus of SLC. Biochim Biophys Acta. 2002 Jul 03; 1571(3):219-24. PMID: 12090936.
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  159. Springer TA. César Milstein, the father of modern immunology. Nat Immunol. 2002 Jun; 3(6):501-3. PMID: 12032559.
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  160. Springer TA. Immunology. Retrospective: César Milstein (1927-2002). Science. 2002 May 17; 296(5571):1253. PMID: 12016298.
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  161. Takagi J, DeBottis DP, Erickson HP, Springer TA. The role of the specificity-determining loop of the integrin beta subunit I-like domain in autonomous expression, association with the alpha subunit, and ligand binding. Biochemistry. 2002 Apr 02; 41(13):4339-47. PMID: 11914080.
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  162. Beglova N, Blacklow SC, Takagi J, Springer TA. Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation. Nat Struct Biol. 2002 Apr; 9(4):282-7. PMID: 11896403.
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  163. Galagan JE, Nusbaum C, Roy A, Endrizzi MG, Macdonald P, FitzHugh W, Calvo S, Engels R, Smirnov S, Atnoor D, Brown A, Allen N, Naylor J, Stange-Thomann N, DeArellano K, Johnson R, Linton L, McEwan P, McKernan K, Talamas J, Tirrell A, Ye W, Zimmer A, Barber RD, Cann I, Graham DE, Grahame DA, Guss AM, Hedderich R, Ingram-Smith C, Kuettner HC, Krzycki JA, Leigh JA, Li W, Liu J, Mukhopadhyay B, Reeve JN, Smith K, Springer TA, Umayam LA, White O, White RH, Conway de Macario E, Ferry JG, Jarrell KF, Jing H, Macario AJ, Paulsen I, Pritchett M, Sowers KR, Swanson RV, Zinder SH, Lander E, Metcalf WW, Birren B. The genome of M. acetivorans reveals extensive metabolic and physiological diversity. Genome Res. 2002 Apr; 12(4):532-42. PMID: 11932238; PMCID: PMC187521.
  164. Ueno T, Hara K, Willis MS, Malin MA, Höpken UE, Gray DH, Matsushima K, Lipp M, Springer TA, Boyd RL, Yoshie O, Takahama Y. Role for CCR7 ligands in the emigration of newly generated T lymphocytes from the neonatal thymus. Immunity. 2002 Feb; 16(2):205-18. PMID: 11869682.
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  165. Ma Q, Shimaoka M, Lu C, Jing H, Carman CV, Springer TA. Activation-induced conformational changes in the I domain region of lymphocyte function-associated antigen 1. J Biol Chem. 2002 Mar 22; 277(12):10638-41. PMID: 11792712.
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  166. Mancini ER, Steen A, Rausina GA, Wong DC, Arnold WR, Gostomski FE, Davies T, Hockett JR, Stubblefield WA, Drottar KR, Springer TA, Errico P. MTBE ambient water quality criteria development: a public/private partnership. Environ Sci Technol. 2002 Jan 15; 36(2):125-9. PMID: 11831214.
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  167. Chang DD, Hoang BQ, Liu J, Springer TA. Molecular basis for interaction between Icap1 alpha PTB domain and beta 1 integrin. J Biol Chem. 2002 Mar 08; 277(10):8140-5. PMID: 11741908.
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  168. de Château M, Chen S, Salas A, Springer TA. Kinetic and mechanical basis of rolling through an integrin and novel Ca2+-dependent rolling and Mg2+-dependent firm adhesion modalities for the alpha 4 beta 7-MAdCAM-1 interaction. Biochemistry. 2001 Nov 20; 40(46):13972-9. PMID: 11705388.
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  169. Shimaoka M, Takagi J, Springer TA. Conformational regulation of integrin structure and function. Annu Rev Biophys Biomol Struct. 2002; 31:485-516. PMID: 11988479.
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  170. Takagi J, Beglova N, Yalamanchili P, Blacklow SC, Springer TA. Definition of EGF-like, closely interacting modules that bear activation epitopes in integrin beta subunits. Proc Natl Acad Sci U S A. 2001 Sep 25; 98(20):11175-80. PMID: 11572973; PMCID: PMC58703.
  171. Kamata T, Tieu KK, Irie A, Springer TA, Takada Y. Amino acid residues in the alpha IIb subunit that are critical for ligand binding to integrin alpha IIbbeta 3 are clustered in the beta-propeller model. J Biol Chem. 2001 Nov 23; 276(47):44275-83. PMID: 11557768.
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  172. Manjunath N, Shankar P, Wan J, Weninger W, Crowley MA, Hieshima K, Springer TA, Fan X, Shen H, Lieberman J, von Andrian UH. Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes. J Clin Invest. 2001 Sep; 108(6):871-8. PMID: 11560956; PMCID: PMC200936.
  173. Smith RS, Fedyk ER, Springer TA, Mukaida N, Iglewski BH, Phipps RP. IL-8 production in human lung fibroblasts and epithelial cells activated by the Pseudomonas autoinducer N-3-oxododecanoyl homoserine lactone is transcriptionally regulated by NF-kappa B and activator protein-2. J Immunol. 2001 Jul 01; 167(1):366-74. PMID: 11418672.
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  174. Jun CD, Shimaoka M, Carman CV, Takagi J, Springer TA. Dimerization and the effectiveness of ICAM-1 in mediating LFA-1-dependent adhesion. Proc Natl Acad Sci U S A. 2001 Jun 05; 98(12):6830-5. PMID: 11391003; PMCID: PMC34438.
  175. Jun CD, Carman CV, Redick SD, Shimaoka M, Erickson HP, Springer TA. Ultrastructure and function of dimeric, soluble intercellular adhesion molecule-1 (ICAM-1). J Biol Chem. 2001 Aug 03; 276(31):29019-27. PMID: 11390397.
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  176. Jeon H, Meng W, Takagi J, Eck MJ, Springer TA, Blacklow SC. Implications for familial hypercholesterolemia from the structure of the LDL receptor YWTD-EGF domain pair. Nat Struct Biol. 2001 Jun; 8(6):499-504. PMID: 11373616.
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  177. Shimaoka M, Lu C, Palframan RT, von Andrian UH, McCormack A, Takagi J, Springer TA. Reversibly locking a protein fold in an active conformation with a disulfide bond: integrin alphaL I domains with high affinity and antagonist activity in vivo. Proc Natl Acad Sci U S A. 2001 May 22; 98(11):6009-14. PMID: 11353828; PMCID: PMC33413.
  178. Springer TA. Immunoaffinity chromatography. Curr Protoc Neurosci. 2001 May; Chapter 5:Unit 5.11. PMID: 18428494.
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  179. Springer TA. Immunoaffinity chromatography. Curr Protoc Immunol. 2001 May; Chapter 8:Unit 8.2. PMID: 18432857.
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  180. Bonifacino JS, Dell'Angelica EC, Springer TA. Immunoprecipitation. Curr Protoc Protein Sci. 2001 May; Chapter 9:Unit 9.8. PMID: 18429217.
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  181. Bonifacino JS, Dell'Angelica EC, Springer TA. Immunoprecipitation. Curr Protoc Mol Biol. 2001 May; Chapter 10:Unit 10.16. PMID: 18265056.
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  182. Takagi J, Erickson HP, Springer TA. C-terminal opening mimics 'inside-out' activation of integrin alpha5beta1. Nat Struct Biol. 2001 May; 8(5):412-6. PMID: 11323715.
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  183. Springer TA. Immunoaffinity chromatography. Curr Protoc Protein Sci. 2001 May; Chapter 9:Unit 9.5. PMID: 18429214.
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  184. Springer TA. Immunoaffinity chromatography. Curr Protoc Mol Biol. 2001 May; Chapter 10:Unit 10.11A. PMID: 18265050.
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  185. Fedyk ER, Jones D, Critchley HO, Phipps RP, Blieden TM, Springer TA. Expression of stromal-derived factor-1 is decreased by IL-1 and TNF and in dermal wound healing. J Immunol. 2001 May 01; 166(9):5749-54. PMID: 11313418.
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  186. Lu C, Ferzly M, Takagi J, Springer TA. Epitope mapping of antibodies to the C-terminal region of the integrin beta 2 subunit reveals regions that become exposed upon receptor activation. J Immunol. 2001 May 01; 166(9):5629-37. PMID: 11313403.
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  187. Bonifacino JS, Dell'Angelica EC, Springer TA. Immunoprecipitation. Curr Protoc Immunol. 2001 May; Chapter 8:Unit 8.3. PMID: 18432858.
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  188. Lu C, Shimaoka M, Ferzly M, Oxvig C, Takagi J, Springer TA. An isolated, surface-expressed I domain of the integrin alphaLbeta2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond. Proc Natl Acad Sci U S A. 2001 Feb 27; 98(5):2387-92. PMID: 11226249; PMCID: PMC30148.
  189. Lu C, Shimaoka M, Zang Q, Takagi J, Springer TA. Locking in alternate conformations of the integrin alphaLbeta2 I domain with disulfide bonds reveals functional relationships among integrin domains. Proc Natl Acad Sci U S A. 2001 Feb 27; 98(5):2393-8. PMID: 11226250; PMCID: PMC30149.
  190. Chen S, Springer TA. Selectin receptor-ligand bonds: Formation limited by shear rate and dissociation governed by the Bell model. Proc Natl Acad Sci U S A. 2001 Jan 30; 98(3):950-5. PMID: 11158576; PMCID: PMC14690.
  191. Lu C, Takagi J, Springer TA. Association of the membrane proximal regions of the alpha and beta subunit cytoplasmic domains constrains an integrin in the inactive state. J Biol Chem. 2001 May 04; 276(18):14642-8. PMID: 11279101.
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  192. Hioe CE, Chien PC, Lu C, Springer TA, Wang XH, Bandres J, Tuen M. LFA-1 expression on target cells promotes human immunodeficiency virus type 1 infection and transmission. J Virol. 2001 Jan; 75(2):1077-82. PMID: 11134324; PMCID: PMC114007.
  193. Zang Q, Springer TA. Amino acid residues in the PSI domain and cysteine-rich repeats of the integrin beta2 subunit that restrain activation of the integrin alpha(X)beta(2). J Biol Chem. 2001 Mar 09; 276(10):6922-9. PMID: 11096074.
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  194. Springer TA, Jing H, Takagi J. A novel Ca2+ binding beta hairpin loop better resembles integrin sequence motifs than the EF hand. Cell. 2000 Aug 04; 102(3):275-7. PMID: 10975518.
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  195. Shimaoka M, Shifman JM, Jing H, Takagi J, Mayo SL, Springer TA. Computational design of an integrin I domain stabilized in the open high affinity conformation. Nat Struct Biol. 2000 Aug; 7(8):674-8. PMID: 10932253.
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  196. Yalamanchili P, Lu C, Oxvig C, Springer TA. Folding and function of I domain-deleted Mac-1 and lymphocyte function-associated antigen-1. J Biol Chem. 2000 Jul 21; 275(29):21877-82. PMID: 10764808.
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  197. Zang Q, Lu C, Huang C, Takagi J, Springer TA. The top of the inserted-like domain of the integrin lymphocyte function-associated antigen-1 beta subunit contacts the alpha subunit beta -propeller domain near beta-sheet 3. J Biol Chem. 2000 Jul 21; 275(29):22202-12. PMID: 10781608.
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  198. Huang C, Zang Q, Takagi J, Springer TA. Structural and functional studies with antibodies to the integrin beta 2 subunit. A model for the I-like domain. J Biol Chem. 2000 Jul 14; 275(28):21514-24. PMID: 10779511.
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  199. Fedyk ER, Ryyan DH, Ritterman I, Springer TA. Maturation decreases responsiveness of human bone marrow B lineage cells to stromal-derived factor 1 (SDF-1). J Leukoc Biol. 1999 Oct; 66(4):667-73. PMID: 10534124.
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  200. Bork P, Doerks T, Springer TA, Snel B. Domains in plexins: links to integrins and transcription factors. Trends Biochem Sci. 1999 Jul; 24(7):261-3. PMID: 10390613.
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  201. Ma Q, Jones D, Springer TA. The chemokine receptor CXCR4 is required for the retention of B lineage and granulocytic precursors within the bone marrow microenvironment. Immunity. 1999 Apr; 10(4):463-71. PMID: 10229189.
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  202. Casasnovas JM, Pieroni C, Springer TA. Lymphocyte function-associated antigen-1 binding residues in intercellular adhesion molecule-2 (ICAM-2) and the integrin binding surface in the ICAM subfamily. Proc Natl Acad Sci U S A. 1999 Mar 16; 96(6):3017-22. PMID: 10077629; PMCID: PMC15887.
  203. Oxvig C, Lu C, Springer TA. Conformational changes in tertiary structure near the ligand binding site of an integrin I domain. Proc Natl Acad Sci U S A. 1999 Mar 02; 96(5):2215-20. PMID: 10051621; PMCID: PMC26763.
  204. Chen S, Springer TA. An automatic braking system that stabilizes leukocyte rolling by an increase in selectin bond number with shear. J Cell Biol. 1999 Jan 11; 144(1):185-200. PMID: 9885254; PMCID: PMC2148129.
  205. Green N, Rosebrook J, Cochran N, Tan K, Wang JH, Springer TA, Briskin MJ. Mutational analysis of MAdCAM-1/alpha4beta7 interactions reveals significant binding determinants in both the first and second immunuglobulin domains. Cell Adhes Commun. 1999; 7(3):167-81. PMID: 10626902.
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  206. Issekutz AC, Rowter D, Springer TA. Role of ICAM-1 and ICAM-2 and alternate CD11/CD18 ligands in neutrophil transendothelial migration. J Leukoc Biol. 1999 Jan; 65(1):117-26. PMID: 9886254.
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  207. Gerwin N, Gonzalo JA, Lloyd C, Coyle AJ, Reiss Y, Banu N, Wang B, Xu H, Avraham H, Engelhardt B, Springer TA, Gutierrez-Ramos JC. Prolonged eosinophil accumulation in allergic lung interstitium of ICAM-2 deficient mice results in extended hyperresponsiveness. Immunity. 1999 Jan; 10(1):9-19. PMID: 10023766.
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  208. Weber C, Springer TA. Interaction of very late antigen-4 with VCAM-1 supports transendothelial chemotaxis of monocytes by facilitating lateral migration. J Immunol. 1998 Dec 15; 161(12):6825-34. PMID: 9862714.
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  209. Nagashima M, Shin'oka T, Nollert G, Shum-Tim D, Hickey PR, Roth SJ, Kirchhoff A, Springer TA, Burke PR, Mayer JE. Effects of a monoclonal antibody to P-selectin on recovery of neonatal lamb hearts after cold cardioplegic ischemia. Circulation. 1998 Nov 10; 98(19 Suppl):II391-7; discussion II397-8. PMID: 9852932.
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  210. Springer TA. An extracellular beta-propeller module predicted in lipoprotein and scavenger receptors, tyrosine kinases, epidermal growth factor precursor, and extracellular matrix components. J Mol Biol. 1998 Nov 06; 283(4):837-62. PMID: 9790844.
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  211. Alon R, Chen S, Fuhlbrigge R, Puri KD, Springer TA. The kinetics and shear threshold of transient and rolling interactions of L-selectin with its ligand on leukocytes. Proc Natl Acad Sci U S A. 1998 Sep 29; 95(20):11631-6. PMID: 9751717; PMCID: PMC21692.
  212. Aoudjit F, Potworowski EF, Springer TA, St-Pierre Y. Protection from lymphoma cell metastasis in ICAM-1 mutant mice: a posthoming event. J Immunol. 1998 Sep 01; 161(5):2333-8. PMID: 9725228.
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  213. Ma Q, Jones D, Borghesani PR, Segal RA, Nagasawa T, Kishimoto T, Bronson RT, Springer TA. Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. Proc Natl Acad Sci U S A. 1998 Aug 04; 95(16):9448-53. PMID: 9689100; PMCID: PMC21358.
  214. Casasnovas JM, Bickford JK, Springer TA. The domain structure of ICAM-1 and the kinetics of binding to rhinovirus. J Virol. 1998 Jul; 72(7):6244-6. PMID: 9621098; PMCID: PMC110451.
  215. Tan K, Casasnovas JM, Liu JH, Briskin MJ, Springer TA, Wang JH. The structure of immunoglobulin superfamily domains 1 and 2 of MAdCAM-1 reveals novel features important for integrin recognition. Structure. 1998 Jun 15; 6(6):793-801. PMID: 9655832.
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  216. Lu C, Oxvig C, Springer TA. The structure of the beta-propeller domain and C-terminal region of the integrin alphaM subunit. Dependence on beta subunit association and prediction of domains. J Biol Chem. 1998 Jun 12; 273(24):15138-47. PMID: 9614126.
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  217. Wang J, Springer TA. Structural specializations of immunoglobulin superfamily members for adhesion to integrins and viruses. Immunol Rev. 1998 Jun; 163:197-215. PMID: 9700512.
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  218. Petruzzelli L, Maduzia L, Springer TA. Differential requirements for LFA-1 binding to ICAM-1 and LFA-1-mediated cell aggregation. J Immunol. 1998 May 01; 160(9):4208-16. PMID: 9574521.
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  219. Kitayama J, Mackay CR, Ponath PD, Springer TA. The C-C chemokine receptor CCR3 participates in stimulation of eosinophil arrest on inflammatory endothelium in shear flow. J Clin Invest. 1998 May 01; 101(9):2017-24. PMID: 9576767; PMCID: PMC508789.
  220. Puri KD, Chen S, Springer TA. Modifying the mechanical property and shear threshold of L-selectin adhesion independently of equilibrium properties. Nature. 1998 Apr 30; 392(6679):930-3. PMID: 9582074.
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  221. Oxvig C, Springer TA. Experimental support for a beta-propeller domain in integrin alpha-subunits and a calcium binding site on its lower surface. Proc Natl Acad Sci U S A. 1998 Apr 28; 95(9):4870-5. PMID: 9560195; PMCID: PMC20180.
  222. Wang CY, Naka Y, Liao H, Oz MC, Springer TA, Gutierrez-Ramos JC, Pinsky DJ. Cardiac graft intercellular adhesion molecule-1 (ICAM-1) and interleukin-1 expression mediate primary isograft failure and induction of ICAM-1 in organs remote from the site of transplantation. Circ Res. 1998 Apr 20; 82(7):762-72. PMID: 9562435.
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  223. Casasnovas JM, Stehle T, Liu JH, Wang JH, Springer TA. A dimeric crystal structure for the N-terminal two domains of intercellular adhesion molecule-1. Proc Natl Acad Sci U S A. 1998 Apr 14; 95(8):4134-9. PMID: 9539702; PMCID: PMC22454.
  224. Bleul CC, Schultze JL, Springer TA. B lymphocyte chemotaxis regulated in association with microanatomic localization, differentiation state, and B cell receptor engagement. J Exp Med. 1998 Mar 02; 187(5):753-62. PMID: 9480985; PMCID: PMC2212170.
  225. Piali L, Weber C, LaRosa G, Mackay CR, Springer TA, Clark-Lewis I, Moser B. The chemokine receptor CXCR3 mediates rapid and shear-resistant adhesion-induction of effector T lymphocytes by the chemokines IP10 and Mig. Eur J Immunol. 1998 Mar; 28(3):961-72. PMID: 9541591.
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  226. Clark RA, Fuhlbrigge RC, Springer TA. L-Selectin ligands that are O-glycoprotease resistant and distinct from MECA-79 antigen are sufficient for tethering and rolling of lymphocytes on human high endothelial venules. J Cell Biol. 1998 Feb 09; 140(3):721-31. PMID: 9456330; PMCID: PMC2140156.
  227. Parolin C, Borsetti A, Choe H, Farzan M, Kolchinsky P, Heesen M, Ma Q, Gerard C, Palú G, Dorf ME, Springer T, Sodroski J. Use of murine CXCR-4 as a second receptor by some T-cell-tropic human immunodeficiency viruses. J Virol. 1998 Feb; 72(2):1652-6. PMID: 9445072; PMCID: PMC124650.
  228. Roth SJ, Diacovo TG, Brenner MB, Rosat JP, Buccola J, Morita CT, Springer TA. Transendothelial chemotaxis of human alpha/beta and gamma/delta T lymphocytes to chemokines. Eur J Immunol. 1998 Jan; 28(1):104-13. PMID: 9485190.
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  229. Pujades C, Alon R, Yauch RL, Masumoto A, Burkly LC, Chen C, Springer TA, Lobb RR, Hemler ME. Defining extracellular integrin alpha-chain sites that affect cell adhesion and adhesion strengthening without altering soluble ligand binding. Mol Biol Cell. 1997 Dec; 8(12):2647-57. PMID: 9398682; PMCID: PMC25734.
  230. Kitayama J, Fuhlbrigge RC, Puri KD, Springer TA. P-selectin, L-selectin, and alpha 4 integrin have distinct roles in eosinophil tethering and arrest on vascular endothelial cells under physiological flow conditions. J Immunol. 1997 Oct 15; 159(8):3929-39. PMID: 9378981.
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  231. Weber C, Lu CF, Casasnovas JM, Springer TA. Role of alpha L beta 2 integrin avidity in transendothelial chemotaxis of mononuclear cells. J Immunol. 1997 Oct 15; 159(8):3968-75. PMID: 9378985.
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  232. Weber C, Springer TA. Neutrophil accumulation on activated, surface-adherent platelets in flow is mediated by interaction of Mac-1 with fibrinogen bound to alphaIIbbeta3 and stimulated by platelet-activating factor. J Clin Invest. 1997 Oct 15; 100(8):2085-93. PMID: 9329974; PMCID: PMC508400.
  233. Alon R, Chen S, Puri KD, Finger EB, Springer TA. The kinetics of L-selectin tethers and the mechanics of selectin-mediated rolling. J Cell Biol. 1997 Sep 08; 138(5):1169-80. PMID: 9281593; PMCID: PMC2136756.
  234. Tanabe S, Heesen M, Yoshizawa I, Berman MA, Luo Y, Bleul CC, Springer TA, Okuda K, Gerard N, Dorf ME. Functional expression of the CXC-chemokine receptor-4/fusin on mouse microglial cells and astrocytes. J Immunol. 1997 Jul 15; 159(2):905-11. PMID: 9218610.
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  235. Lu CF, Springer TA. The alpha subunit cytoplasmic domain regulates the assembly and adhesiveness of integrin lymphocyte function-associated antigen-1. J Immunol. 1997 Jul 01; 159(1):268-78. PMID: 9200463.
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  236. Casasnovas JM, Springer TA, Liu JH, Harrison SC, Wang JH. Crystal structure of ICAM-2 reveals a distinctive integrin recognition surface. Nature. 1997 May 15; 387(6630):312-5. PMID: 9153399.
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  237. Kishimoto T, Goyert S, Kikutani H, Mason D, Miyasaka M, Moretta L, Ohno T, Okumura K, Shaw S, Springer TA, Sugamura K, Sugawara H, von dem Borne AE, Zola H. CD antigens 1996. Blood. 1997 May 15; 89(10):3502. PMID: 9160654.
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  238. Clark RA, Erickson HP, Springer TA. Tenascin supports lymphocyte rolling. J Cell Biol. 1997 May 05; 137(3):755-65. PMID: 9151679; PMCID: PMC2139881.
  239. Chen S, Alon R, Fuhlbrigge RC, Springer TA. Rolling and transient tethering of leukocytes on antibodies reveal specializations of selectins. Proc Natl Acad Sci U S A. 1997 Apr 01; 94(7):3172-7. PMID: 9096365; PMCID: PMC20341.
  240. Kishimoto T, Goyert S, Kikutani H, Mason D, Miyasaka M, Moretta L, Ohno T, Okumura K, Shaw S, Springer TA, Sugamura K, Sugawara H, von dem Borne AE, Zola H. Update of CD antigens, 1996. J Immunol. 1997 Apr 01; 158(7):3035-6. PMID: 9120254.
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  241. Huang C, Springer TA. Folding of the beta-propeller domain of the integrin alphaL subunit is independent of the I domain and dependent on the beta2 subunit. Proc Natl Acad Sci U S A. 1997 Apr 01; 94(7):3162-7. PMID: 9096363; PMCID: PMC20339.
  242. Huang C, Lu C, Springer TA. Folding of the conserved domain but not of flanking regions in the integrin beta2 subunit requires association with the alpha subunit. Proc Natl Acad Sci U S A. 1997 Apr 01; 94(7):3156-61. PMID: 9096362; PMCID: PMC20338.
  243. Bleul CC, Wu L, Hoxie JA, Springer TA, Mackay CR. The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes. Proc Natl Acad Sci U S A. 1997 Mar 04; 94(5):1925-30. PMID: 9050881; PMCID: PMC20019.
  244. Kishimoto T, Goyert S, Kikutani H, Mason D, Miyasaka M, Moretta L, Ohno T, Okumura K, Shaw S, Springer TA, Sugamura K, Sugawara H, von dem Borne AE, Zola H. Update: new CD antigens, 1996. Tissue Antigens. 1997 Mar; 49(3 Pt 1):287-8. PMID: 9098941.
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  245. Kitayama J, Carr MW, Roth SJ, Buccola J, Springer TA. Contrasting responses to multiple chemotactic stimuli in transendothelial migration: heterologous desensitization in neutrophils and augmentation of migration in eosinophils. J Immunol. 1997 Mar 01; 158(5):2340-9. PMID: 9036983.
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  246. Springer TA. Folding of the N-terminal, ligand-binding region of integrin alpha-subunits into a beta-propeller domain. Proc Natl Acad Sci U S A. 1997 Jan 07; 94(1):65-72. PMID: 8990162; PMCID: PMC19237.
  247. Aiuti A, Webb IJ, Bleul C, Springer T, Gutierrez-Ramos JC. The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood. J Exp Med. 1997 Jan 06; 185(1):111-20. PMID: 8996247; PMCID: PMC2196104.
  248. Puri KD, Finger EB, Springer TA. The faster kinetics of L-selectin than of E-selectin and P-selectin rolling at comparable binding strength. J Immunol. 1997 Jan 01; 158(1):405-13. PMID: 8977216.
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  249. Weber KS, York MR, Springer TA, Klickstein LB. Characterization of lymphocyte function-associated antigen 1 (LFA-1)-deficient T cell lines: the alphaL and beta2 subunits are interdependent for cell surface expression. J Immunol. 1997 Jan 01; 158(1):273-9. PMID: 8977199.
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  250. Nagasawa T, Nakajima T, Tachibana K, Iizasa H, Bleul CC, Yoshie O, Matsushima K, Yoshida N, Springer TA, Kishimoto T. Molecular cloning and characterization of a murine pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 receptor, a murine homolog of the human immunodeficiency virus 1 entry coreceptor fusin. Proc Natl Acad Sci U S A. 1996 Dec 10; 93(25):14726-9. PMID: 8962122; PMCID: PMC26203.
  251. Finger EB, Bruehl RE, Bainton DF, Springer TA. A differential role for cell shape in neutrophil tethering and rolling on endothelial selectins under flow. J Immunol. 1996 Dec 01; 157(11):5085-96. PMID: 8943418.
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  252. Alon R, Fuhlbrigge RC, Finger EB, Springer TA. Interactions through L-selectin between leukocytes and adherent leukocytes nucleate rolling adhesions on selectins and VCAM-1 in shear flow. J Cell Biol. 1996 Nov; 135(3):849-65. PMID: 8909556; PMCID: PMC2121073.
  253. Fuhlbrigge RC, Alon R, Puri KD, Lowe JB, Springer TA. Sialylated, fucosylated ligands for L-selectin expressed on leukocytes mediate tethering and rolling adhesions in physiologic flow conditions. J Cell Biol. 1996 Nov; 135(3):837-48. PMID: 8909555; PMCID: PMC2121069.
  254. Weber C, Kitayama J, Springer TA. Differential regulation of beta 1 and beta 2 integrin avidity by chemoattractants in eosinophils. Proc Natl Acad Sci U S A. 1996 Oct 01; 93(20):10939-44. PMID: 8855287; PMCID: PMC38262.
  255. Klickstein LB, York MR, Fougerolles AR, Springer TA. Localization of the binding site on intercellular adhesion molecule-3 (ICAM-3) for lymphocyte function-associated antigen 1 (LFA-1). J Biol Chem. 1996 Sep 27; 271(39):23920-7. PMID: 8798624.
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  256. Bleul CC, Fuhlbrigge RC, Casasnovas JM, Aiuti A, Springer TA. A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1) J Exp Med. 1996 Sep 01; 184(3):1101-9. PMID: 9064327; PMCID: PMC2192798.
  257. Bleul CC, Farzan M, Choe H, Parolin C, Clark-Lewis I, Sodroski J, Springer TA. The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature. 1996 Aug 29; 382(6594):829-33. PMID: 8752280.
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  258. Clark RA, Alon R, Springer TA. CD44 and hyaluronan-dependent rolling interactions of lymphocytes on tonsillar stroma. J Cell Biol. 1996 Aug; 134(4):1075-87. PMID: 8769428; PMCID: PMC2120952.
  259. Bruehl RE, Springer TA, Bainton DF. Quantitation of L-selectin distribution on human leukocyte microvilli by immunogold labeling and electron microscopy. J Histochem Cytochem. 1996 Aug; 44(8):835-44. PMID: 8756756.
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  260. Weber C, Alon R, Moser B, Springer TA. Sequential regulation of alpha 4 beta 1 and alpha 5 beta 1 integrin avidity by CC chemokines in monocytes: implications for transendothelial chemotaxis. J Cell Biol. 1996 Aug; 134(4):1063-73. PMID: 8769427; PMCID: PMC2120967.
  261. Diacovo TG, Puri KD, Warnock RA, Springer TA, von Andrian UH. Platelet-mediated lymphocyte delivery to high endothelial venules. Science. 1996 Jul 12; 273(5272):252-5. PMID: 8662511.
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  262. Verdrengh M, Springer TA, Gutierrez-Ramos JC, Tarkowski A. Role of intercellular adhesion molecule 1 in pathogenesis of staphylococcal arthritis and in host defense against staphylococcal bacteremia. Infect Immun. 1996 Jul; 64(7):2804-7. PMID: 8698512; PMCID: PMC174143.
  263. Parkos CA, Colgan SP, Diamond MS, Nusrat A, Liang TW, Springer TA, Madara JL. Expression and polarization of intercellular adhesion molecule-1 on human intestinal epithelia: consequences for CD11b/CD18-mediated interactions with neutrophils. Mol Med. 1996 Jul; 2(4):489-505. PMID: 8827719; PMCID: PMC2230166.
  264. Diacovo TG, Roth SJ, Buccola JM, Bainton DF, Springer TA. Neutrophil rolling, arrest, and transmigration across activated, surface-adherent platelets via sequential action of P-selectin and the beta 2-integrin CD11b/CD18. Blood. 1996 Jul 01; 88(1):146-57. PMID: 8704169.
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  265. Xu H, Bickford JK, Luther E, Carpenito C, Takei F, Springer TA. Characterization of murine intercellular adhesion molecule-2. J Immunol. 1996 Jun 15; 156(12):4909-14. PMID: 8648141.
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  266. Wong DA, Davis EM, LeBeau M, Springer TA. Cloning and chromosomal localization of a novel gene-encoding a human beta 2-integrin alpha subunit. Gene. 1996 Jun 01; 171(2):291-4. PMID: 8666289.
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  267. Soriano SG, Lipton SA, Wang YF, Xiao M, Springer TA, Gutierrez-Ramos JC, Hickey PR. Intercellular adhesion molecule-1-deficient mice are less susceptible to cerebral ischemia-reperfusion injury. Ann Neurol. 1996 May; 39(5):618-24. PMID: 8619547.
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  268. Puri KD, Springer TA. A schiff base with mildly oxidized carbohydrate ligands stabilizes L-selectin and not P-selectin or E-selectin rolling adhesions in shear flow. J Biol Chem. 1996 Mar 08; 271(10):5404-13. PMID: 8621395.
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  269. Diacovo TG, Roth SJ, Morita CT, Rosat JP, Brenner MB, Springer TA. Interactions of human alpha/beta and gamma/delta T lymphocyte subsets in shear flow with E-selectin and P-selectin. J Exp Med. 1996 Mar 01; 183(3):1193-203. PMID: 8642261; PMCID: PMC2192327.
  270. Girard JP, Springer TA. Modulation of endothelial cell adhesion by hevin, an acidic protein associated with high endothelial venules. J Biol Chem. 1996 Feb 23; 271(8):4511-7. PMID: 8626806.
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  271. Kelly KJ, Williams WW, Colvin RB, Meehan SM, Springer TA, Gutierrez-Ramos JC, Bonventre JV. Intercellular adhesion molecule-1-deficient mice are protected against ischemic renal injury. J Clin Invest. 1996 Feb 15; 97(4):1056-63. PMID: 8613529; PMCID: PMC507153.
  272. Dustin ML, Ferguson LM, Chan PY, Springer TA, Golan DE. Visualization of CD2 interaction with LFA-3 and determination of the two-dimensional dissociation constant for adhesion receptors in a contact area. J Cell Biol. 1996 Feb; 132(3):465-74. PMID: 8636222; PMCID: PMC2120727.
  273. Carr MW, Alon R, Springer TA. The C-C chemokine MCP-1 differentially modulates the avidity of beta 1 and beta 2 integrins on T lymphocytes. Immunity. 1996 Feb; 4(2):179-87. PMID: 8624808.
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  274. Finger EB, Puri KD, Alon R, Lawrence MB, von Andrian UH, Springer TA. Adhesion through L-selectin requires a threshold hydrodynamic shear. Nature. 1996 Jan 18; 379(6562):266-9. PMID: 8538793.
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  275. Connolly ES, Winfree CJ, Springer TA, Naka Y, Liao H, Yan SD, Stern DM, Solomon RA, Gutierrez-Ramos JC, Pinsky DJ. Cerebral protection in homozygous null ICAM-1 mice after middle cerebral artery occlusion. Role of neutrophil adhesion in the pathogenesis of stroke. J Clin Invest. 1996 Jan 01; 97(1):209-16. PMID: 8550836; PMCID: PMC507081.
  276. Cilesiz I, Springer T, Thomsen S, Welch AJ. Controlled temperature tissue fusion: argon laser welding of canine intestine in vitro. Lasers Surg Med. 1996; 18(4):325-34. PMID: 8732571.
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  277. Roth SJ, Carr MW, Rose SS, Springer TA. Characterization of transendothelial chemotaxis of T lymphocytes. J Immunol Methods. 1995 Dec 15; 188(1):97-116. PMID: 8551044.
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  278. Roth SJ, Carr MW, Springer TA. C-C chemokines, but not the C-X-C chemokines interleukin-8 and interferon-gamma inducible protein-10, stimulate transendothelial chemotaxis of T lymphocytes. Eur J Immunol. 1995 Dec; 25(12):3482-8. PMID: 8566041.
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  279. Yokota A, Murata N, Saiki O, Shimizu M, Springer TA, Kishimoto T. High avidity state of leukocyte function-associated antigen-1 on rheumatoid synovial fluid T lymphocytes. J Immunol. 1995 Oct 15; 155(8):4118-24. PMID: 7561125.
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  280. Gonzalo JA, Martinez C, Springer TA, Gutierrez-Ramos JC. ICAM-1 is required for T cell proliferation but not for anergy or apoptosis induced by Staphylococcus aureus enterotoxin B in vivo. Int Immunol. 1995 Oct; 7(10):1691-8. PMID: 8562515.
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  281. de Fougerolles A, Springer TA. Ideas crystallized on immunoglobulin superfamily-integrin interactions. Chem Biol. 1995 Oct; 2(10):639-43. PMID: 9383469.
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  282. Puri KD, Finger EB, Gaudernack G, Springer TA. Sialomucin CD34 is the major L-selectin ligand in human tonsil high endothelial venules. J Cell Biol. 1995 Oct; 131(1):261-70. PMID: 7559783; PMCID: PMC2120586.
  283. Kinashi T, Escobedo JA, Williams LT, Takatsu K, Springer TA. Receptor tyrosine kinase stimulates cell-matrix adhesion by phosphatidylinositol 3 kinase and phospholipase C-gamma 1 pathways. Blood. 1995 Sep 15; 86(6):2086-90. PMID: 7545020.
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  284. Diamond MS, Alon R, Parkos CA, Quinn MT, Springer TA. Heparin is an adhesive ligand for the leukocyte integrin Mac-1 (CD11b/CD1). J Cell Biol. 1995 Sep; 130(6):1473-82. PMID: 7559767; PMCID: PMC2120570.
  285. Girard JP, Springer TA. High endothelial venules (HEVs): specialized endothelium for lymphocyte migration. Immunol Today. 1995 Sep; 16(9):449-57. PMID: 7546210.
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  286. Huang C, Springer TA. A binding interface on the I domain of lymphocyte function-associated antigen-1 (LFA-1) required for specific interaction with intercellular adhesion molecule 1 (ICAM-1). J Biol Chem. 1995 Aug 11; 270(32):19008-16. PMID: 7642561.
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  287. Petruzzelli L, Maduzia L, Springer TA. Activation of lymphocyte function-associated molecule-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) mimicked by an antibody directed against CD18. J Immunol. 1995 Jul 15; 155(2):854-66. PMID: 7608563.
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  288. Kinashi T, Springer TA. Regulation of cell-matrix adhesion by receptor tyrosine kinases. Leuk Lymphoma. 1995 Jul; 18(3-4):203-8. PMID: 8535183.
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  289. Casasnovas JM, Springer TA. Kinetics and thermodynamics of virus binding to receptor. Studies with rhinovirus, intercellular adhesion molecule-1 (ICAM-1), and surface plasmon resonance. J Biol Chem. 1995 Jun 02; 270(22):13216-24. PMID: 7768920.
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  290. Kassner PD, Alon R, Springer TA, Hemler ME. Specialized functional properties of the integrin alpha 4 cytoplasmic domain. Mol Biol Cell. 1995 Jun; 6(6):661-74. PMID: 7579686; PMCID: PMC301227.
  291. Alon R, Feizi T, Yuen CT, Fuhlbrigge RC, Springer TA. Glycolipid ligands for selectins support leukocyte tethering and rolling under physiologic flow conditions. J Immunol. 1995 May 15; 154(10):5356-66. PMID: 7537307.
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  292. Sugie K, Nakamura K, Teshigawara K, Diamond MS, Springer TA, Nakamura Y, Leonard WJ, Uchida A, Yodoi J. Activation of natural killer cells by the mAb YTA-1 that recognizes leukocyte function-associated antigen-1. Int Immunol. 1995 May; 7(5):763-9. PMID: 7547703.
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  293. Alon R, Hammer DA, Springer TA. Lifetime of the P-selectin-carbohydrate bond and its response to tensile force in hydrodynamic flow. Nature. 1995 Apr 06; 374(6522):539-42. PMID: 7535385.
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  294. de Fougerolles AR, Diamond MS, Springer TA. Heterogenous glycosylation of ICAM-3 and lack of interaction with Mac-1 and p150,95. Eur J Immunol. 1995 Apr; 25(4):1008-12. PMID: 7737271.
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  295. Lawrence MB, Berg EL, Butcher EC, Springer TA. Rolling of lymphocytes and neutrophils on peripheral node addressin and subsequent arrest on ICAM-1 in shear flow. Eur J Immunol. 1995 Apr; 25(4):1025-31. PMID: 7537667.
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  296. Alon R, Kassner PD, Carr MW, Finger EB, Hemler ME, Springer TA. The integrin VLA-4 supports tethering and rolling in flow on VCAM-1. J Cell Biol. 1995 Mar; 128(6):1243-53. PMID: 7534768; PMCID: PMC2120426.
  297. Stahmann KP, Monschau N, Sahm H, Koschel A, Gawronski M, Conrad H, Springer T, Kopp F. Structural properties of native and sonicated cinerean, a beta- (1-->3) (1-->6)-D-glucan produced by Botrytis cinerea. Carbohydr Res. 1995 Jan 03; 266(1):115-28. PMID: 7697647.
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  298. Springer TA. Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. Annu Rev Physiol. 1995; 57:827-72. PMID: 7778885.
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  299. Girard JP, Springer TA. Cloning from purified high endothelial venule cells of hevin, a close relative of the antiadhesive extracellular matrix protein SPARC. Immunity. 1995 Jan; 2(1):113-23. PMID: 7600298.
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  300. Kinashi T, St Pierre Y, Springer TA. Expression of glycophosphatidylinositol-anchored and -non-anchored isoforms of vascular cell adhesion molecule 1 in murine stromal and endothelial cells. J Leukoc Biol. 1995 Jan; 57(1):168-73. PMID: 7530279.
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  301. Alon R, Rossiter H, Wang X, Springer TA, Kupper TS. Distinct cell surface ligands mediate T lymphocyte attachment and rolling on P and E selectin under physiological flow. J Cell Biol. 1994 Dec; 127(5):1485-95. PMID: 7525609; PMCID: PMC2120244.
  302. Butini L, De Fougerolles AR, Vaccarezza M, Graziosi C, Cohen DI, Montroni M, Springer TA, Pantaleo G, Fauci AS. Intercellular adhesion molecules (ICAM)-1 ICAM-2 and ICAM-3 function as counter-receptors for lymphocyte function-associated molecule 1 in human immunodeficiency virus-mediated syncytia formation. Eur J Immunol. 1994 Sep; 24(9):2191-5. PMID: 7916296.
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  303. Casasnovas JM, Springer TA. Pathway of rhinovirus disruption by soluble intercellular adhesion molecule 1 (ICAM-1): an intermediate in which ICAM-1 is bound and RNA is released. J Virol. 1994 Sep; 68(9):5882-9. PMID: 7914550; PMCID: PMC236993.
  304. Diacovo TG, deFougerolles AR, Bainton DF, Springer TA. A functional integrin ligand on the surface of platelets: intercellular adhesion molecule-2. J Clin Invest. 1994 Sep; 94(3):1243-51. PMID: 8083366; PMCID: PMC295209.
  305. Xu H, Gonzalo JA, St Pierre Y, Williams IR, Kupper TS, Cotran RS, Springer TA, Gutierrez-Ramos JC. Leukocytosis and resistance to septic shock in intercellular adhesion molecule 1-deficient mice. J Exp Med. 1994 Jul 01; 180(1):95-109. PMID: 7911822; PMCID: PMC2191562.
  306. Borregaard N, Kjeldsen L, Sengeløv H, Diamond MS, Springer TA, Anderson HC, Kishimoto TK, Bainton DF. Changes in subcellular localization and surface expression of L-selectin, alkaline phosphatase, and Mac-1 in human neutrophils during stimulation with inflammatory mediators. J Leukoc Biol. 1994 Jul; 56(1):80-7. PMID: 7517990.
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  307. Diamond MS, Springer TA. The dynamic regulation of integrin adhesiveness. Curr Biol. 1994 Jun 01; 4(6):506-17. PMID: 7922371.
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  308. Lawrence MB, Bainton DF, Springer TA. Neutrophil tethering to and rolling on E-selectin are separable by requirement for L-selectin. Immunity. 1994 May; 1(2):137-45. PMID: 7534197.
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  309. Bilsland CA, Diamond MS, Springer TA. The leukocyte integrin p150,95 (CD11c/CD18) as a receptor for iC3b. Activation by a heterologous beta subunit and localization of a ligand recognition site to the I domain. J Immunol. 1994 May 01; 152(9):4582-9. PMID: 7512600.
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  310. Carr MW, Roth SJ, Luther E, Rose SS, Springer TA. Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant. Proc Natl Acad Sci U S A. 1994 Apr 26; 91(9):3652-6. PMID: 8170963; PMCID: PMC43639.
  311. Vonderheide RH, Tedder TF, Springer TA, Staunton DE. Residues within a conserved amino acid motif of domains 1 and 4 of VCAM-1 are required for binding to VLA-4. J Cell Biol. 1994 Apr; 125(1):215-22. PMID: 7511143; PMCID: PMC2120002.
  312. Bilsland CA, Springer TA. Cloning and expression of the chicken CD18 cDNA. J Leukoc Biol. 1994 Apr; 55(4):501-6. PMID: 7908319.
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  313. Schlossman SF, Boumsell L, Gilks W, Harlan JM, Kishimoto T, Morimoto C, Ritz J, Shaw S, Silverstein RL, Springer TA, et al. CD antigens 1993. Immunol Today. 1994 Mar; 15(3):98-9. PMID: 7909665.
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  314. Kinashi T, Springer TA. Steel factor and c-kit regulate cell-matrix adhesion. Blood. 1994 Feb 15; 83(4):1033-8. PMID: 7509207.
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  315. Schlossman SF, Boumsell L, Gilks W, Harlan JM, Kishimoto T, Morimoto C, Ritz J, Shaw S, Silverstein RL, Springer TA, et al. CD antigens 1993. Blood. 1994 Feb 15; 83(4):879-80. PMID: 8111060.
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  316. de Fougerolles AR, Qin X, Springer TA. Characterization of the function of intercellular adhesion molecule (ICAM)-3 and comparison with ICAM-1 and ICAM-2 in immune responses. J Exp Med. 1994 Feb 01; 179(2):619-29. PMID: 7905020; PMCID: PMC2191386.
  317. Springer TA. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell. 1994 Jan 28; 76(2):301-14. PMID: 7507411.
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  318. Kinashi T, Springer TA. Adhesion molecules in hematopoietic cells. Blood Cells. 1994; 20(1):25-44. PMID: 7527678.
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  319. Schlossman SF, Boumsell L, Gilks W, Harlan JM, Kishimoto T, Morimoto C, Ritz J, Shaw S, Silverstein RL, Springer TA, et al. CD antigens 1993. J Immunol. 1994 Jan 01; 152(1):1-2. PMID: 7902854.
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  320. Lawrence MB, Springer TA. Neutrophils roll on E-selectin. J Immunol. 1993 Dec 01; 151(11):6338-46. PMID: 7504018.
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  321. López Rodríguez C, Nueda A, Grospierre B, Sánchez-Madrid F, Fischer A, Springer TA, Corbí AL. Characterization of two new CD18 alleles causing severe leukocyte adhesion deficiency. Eur J Immunol. 1993 Nov; 23(11):2792-8. PMID: 7901025.
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  322. Sengeløv H, Kjeldsen L, Diamond MS, Springer TA, Borregaard N. Subcellular localization and dynamics of Mac-1 (alpha m beta 2) in human neutrophils. J Clin Invest. 1993 Sep; 92(3):1467-76. PMID: 8376598; PMCID: PMC288292.
  323. Hondalus MK, Diamond MS, Rosenthal LA, Springer TA, Mosser DM. The intracellular bacterium Rhodococcus equi requires Mac-1 to bind to mammalian cells. Infect Immun. 1993 Jul; 61(7):2919-29. PMID: 8514396; PMCID: PMC280940.
  324. Martin S, Casasnovas JM, Staunton DE, Springer TA. Efficient neutralization and disruption of rhinovirus by chimeric ICAM-1/immunoglobulin molecules. J Virol. 1993 Jun; 67(6):3561-8. PMID: 8098781; PMCID: PMC237703.
  325. Martin S, Martin A, Staunton DE, Springer TA. Functional studies of truncated soluble intercellular adhesion molecule 1 expressed in Escherichia coli. Antimicrob Agents Chemother. 1993 Jun; 37(6):1278-84. PMID: 8101071; PMCID: PMC187953.
  326. Martin S, Casanovas JM, Staunton DE, Springer TA. [Successful prevention of rhinovirus infections with chimeric ICAM-1 immunoglobulin in vitro]. Med Klin (Munich). 1993 Apr 15; 88(4):193-7. PMID: 8098506.
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  327. de Fougerolles AR, Klickstein LB, Springer TA. Cloning and expression of intercellular adhesion molecule 3 reveals strong homology to other immunoglobulin family counter-receptors for lymphocyte function-associated antigen 1. J Exp Med. 1993 Apr 01; 177(4):1187-92. PMID: 8459213; PMCID: PMC2190956.
  328. Kirchhausen T, Staunton DE, Springer TA. Location of the domains of ICAM-1 by immunolabeling and single-molecule electron microscopy. J Leukoc Biol. 1993 Mar; 53(3):342-6. PMID: 8095966.
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  329. Diamond MS, Garcia-Aguilar J, Bickford JK, Corbi AL, Springer TA. The I domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b/CD18) for four distinct adhesion ligands. J Cell Biol. 1993 Feb; 120(4):1031-43. PMID: 7679388; PMCID: PMC2200080.
  330. Diamond MS, Springer TA. A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen. J Cell Biol. 1993 Jan; 120(2):545-56. PMID: 7678422; PMCID: PMC2119505.
  331. Springer TA. Signals on endothelium for lymphocyte recirculation and leukocyte emigration: the area code paradigm. Harvey Lect. 1993-1994; 89:53-103. PMID: 7622362.
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  332. Staunton DE, Ockenhouse CF, Springer TA. Soluble intercellular adhesion molecule 1-immunoglobulin G1 immunoadhesin mediates phagocytosis of malaria-infected erythrocytes. J Exp Med. 1992 Nov 01; 176(5):1471-6. PMID: 1383388; PMCID: PMC2119430.
  333. Xu H, Tong IL, De Fougerolles AR, Springer TA. Isolation, characterization, and expression of mouse ICAM-2 complementary and genomic DNA. J Immunol. 1992 Oct 15; 149(8):2650-5. PMID: 1401904.
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  334. Carpén O, Pallai P, Staunton DE, Springer TA. Association of intercellular adhesion molecule-1 (ICAM-1) with actin-containing cytoskeleton and alpha-actinin. J Cell Biol. 1992 Sep; 118(5):1223-34. PMID: 1355095; PMCID: PMC2289592.
  335. Tözeren A, Mackie LH, Lawrence MB, Chan PY, Dustin ML, Springer TA. Micromanipulation of adhesion of phorbol 12-myristate-13-acetate-stimulated T lymphocytes to planar membranes containing intercellular adhesion molecule-1. Biophys J. 1992 Jul; 63(1):247-58. PMID: 1358239; PMCID: PMC1262142.
  336. Vonderheide RH, Springer TA. Lymphocyte adhesion through very late antigen 4: evidence for a novel binding site in the alternatively spliced domain of vascular cell adhesion molecule 1 and an additional alpha 4 integrin counter-receptor on stimulated endothelium. J Exp Med. 1992 Jun 01; 175(6):1433-42. PMID: 1375259; PMCID: PMC2119261.
  337. Staunton DE, Gaur A, Chan PY, Springer TA. Internalization of a major group human rhinovirus does not require cytoplasmic or transmembrane domains of ICAM-1. J Immunol. 1992 May 15; 148(10):3271-4. PMID: 1349619.
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  338. Dustin ML, Carpen O, Springer TA. Regulation of locomotion and cell-cell contact area by the LFA-1 and ICAM-1 adhesion receptors. J Immunol. 1992 May 01; 148(9):2654-63. PMID: 1349320.
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  339. Tözeren A, Sung KL, Sung LA, Dustin ML, Chan PY, Springer TA, Chien S. Micromanipulation of adhesion of a Jurkat cell to a planar bilayer membrane containing lymphocyte function-associated antigen 3 molecules. J Cell Biol. 1992 Feb; 116(4):997-1006. PMID: 1370839; PMCID: PMC2289335.
  340. Chan PY, Springer TA. Effect of lengthening lymphocyte function-associated antigen 3 on adhesion to CD2. Mol Biol Cell. 1992 Feb; 3(2):157-66. PMID: 1348006; PMCID: PMC275515.
  341. Ockenhouse CF, Betageri R, Springer TA, Staunton DE. Plasmodium falciparum-infected erythrocytes bind ICAM-1 at a site distinct from LFA-1, Mac-1, and human rhinovirus. Cell. 1992 Jan 10; 68(1):63-9. PMID: 1346257.
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  342. Mosser DM, Springer TA, Diamond MS. Leishmania promastigotes require opsonic complement to bind to the human leukocyte integrin Mac-1 (CD11b/CD18). J Cell Biol. 1992 Jan; 116(2):511-20. PMID: 1730765; PMCID: PMC2289275.
  343. de Fougerolles AR, Springer TA. Intercellular adhesion molecule 3, a third adhesion counter-receptor for lymphocyte function-associated molecule 1 on resting lymphocytes. J Exp Med. 1992 Jan 01; 175(1):185-90. PMID: 1730916; PMCID: PMC2119096.
  344. Springer TA. The next cluster of differentiation (CD) workshop. Nature. 1991 Dec 05; 354(6352):415-6. PMID: 1956408.
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  345. Hibbs ML, Jakes S, Stacker SA, Wallace RW, Springer TA. The cytoplasmic domain of the integrin lymphocyte function-associated antigen 1 beta subunit: sites required for binding to intercellular adhesion molecule 1 and the phorbol ester-stimulated phosphorylation site. J Exp Med. 1991 Nov 01; 174(5):1227-38. PMID: 1682411; PMCID: PMC2119009.
  346. Carpén O, Dustin ML, Springer TA, Swafford JA, Beckett LA, Caulfield JP. Motility and ultrastructure of large granular lymphocytes on lipid bilayers reconstituted with adhesion receptors LFA-1, ICAM-1, and two isoforms of LFA-3. J Cell Biol. 1991 Nov; 115(3):861-71. PMID: 1717493; PMCID: PMC2289190.
  347. Springer TA. Cell adhesion. A birth certificate for CD2. Nature. 1991 Oct 24; 353(6346):704-5. PMID: 1719420.
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  348. Chan PY, Lawrence MB, Dustin ML, Ferguson LM, Golan DE, Springer TA. Influence of receptor lateral mobility on adhesion strengthening between membranes containing LFA-3 and CD2. J Cell Biol. 1991 Oct; 115(1):245-55. PMID: 1717480; PMCID: PMC2289925.
  349. Schwartz MA, Ingber DE, Lawrence M, Springer TA, Lechene C. Multiple integrins share the ability to induce elevation of intracellular pH. Exp Cell Res. 1991 Aug; 195(2):533-5. PMID: 1712734.
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  350. Kaufmann Y, Tseng E, Springer TA. Cloning of the murine lymphocyte function-associated molecule-1 alpha-subunit and its expression in COS cells. J Immunol. 1991 Jul 01; 147(1):369-74. PMID: 2051027.
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  351. de Fougerolles AR, Stacker SA, Schwarting R, Springer TA. Characterization of ICAM-2 and evidence for a third counter-receptor for LFA-1. J Exp Med. 1991 Jul 01; 174(1):253-67. PMID: 1676048; PMCID: PMC2118873.
  352. Diamond MS, Staunton DE, Marlin SD, Springer TA. Binding of the integrin Mac-1 (CD11b/CD18) to the third immunoglobulin-like domain of ICAM-1 (CD54) and its regulation by glycosylation. Cell. 1991 Jun 14; 65(6):961-71. PMID: 1675157.
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  353. Lawrence MB, Springer TA. Leukocytes roll on a selectin at physiologic flow rates: distinction from and prerequisite for adhesion through integrins. Cell. 1991 May 31; 65(5):859-73. PMID: 1710173.
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  354. Hibbs ML, Xu H, Stacker SA, Springer TA. Regulation of adhesion of ICAM-1 by the cytoplasmic domain of LFA-1 integrin beta subunit. Science. 1991 Mar 29; 251(5001):1611-3. PMID: 1672776.
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  355. Springer TA, Lasky LA. Cell adhesion. Sticky sugars for selectins. Nature. 1991 Jan 17; 349(6306):196-7. PMID: 1987472.
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  356. Stacker SA, Springer TA. Leukocyte integrin P150,95 (CD11c/CD18) functions as an adhesion molecule binding to a counter-receptor on stimulated endothelium. J Immunol. 1991 Jan 15; 146(2):648-55. PMID: 1702811.
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  357. Dustin ML, Springer TA. Role of lymphocyte adhesion receptors in transient interactions and cell locomotion. Annu Rev Immunol. 1991; 9:27-66. PMID: 1716919.
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  358. Diamond MS, Staunton DE, de Fougerolles AR, Stacker SA, Garcia-Aguilar J, Hibbs ML, Springer TA. ICAM-1 (CD54): a counter-receptor for Mac-1 (CD11b/CD18). J Cell Biol. 1990 Dec; 111(6 Pt 2):3129-39. PMID: 1980124; PMCID: PMC2116396.
  359. Springer TA. Leucocyte adhesion to cells. Scand J Immunol. 1990 Sep; 32(3):211-6. PMID: 2205903.
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  360. Johnston SC, Dustin ML, Hibbs ML, Springer TA. On the species specificity of the interaction of LFA-1 with intercellular adhesion molecules. J Immunol. 1990 Aug 15; 145(4):1181-7. PMID: 2199576.
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  361. Springer TA. Adhesion receptors of the immune system. Nature. 1990 Aug 02; 346(6283):425-34. PMID: 1974032.
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  362. Wardlaw AJ, Hibbs ML, Stacker SA, Springer TA. Distinct mutations in two patients with leukocyte adhesion deficiency and their functional correlates. J Exp Med. 1990 Jul 01; 172(1):335-45. PMID: 1694220; PMCID: PMC2188166.
  363. Staunton DE, Dustin ML, Erickson HP, Springer TA. The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinovirus. Cell. 1990 Apr 20; 61(2):243-54. PMID: 1970514.
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  364. Larson RS, Springer TA. Structure and function of leukocyte integrins. Immunol Rev. 1990 Apr; 114:181-217. PMID: 2196220.
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  365. Larson RS, Hibbs ML, Springer TA. The leukocyte integrin LFA-1 reconstituted by cDNA transfection in a nonhematopoietic cell line is functionally active and not transiently regulated. Cell Regul. 1990 Mar; 1(4):359-67. PMID: 1712636; PMCID: PMC361493.
  366. Marlin SD, Staunton DE, Springer TA, Stratowa C, Sommergruber W, Merluzzi VJ. A soluble form of intercellular adhesion molecule-1 inhibits rhinovirus infection. Nature. 1990 Mar 01; 344(6261):70-2. PMID: 1968231.
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  367. Hibbs ML, Wardlaw AJ, Stacker SA, Anderson DC, Lee A, Roberts TM, Springer TA. Transfection of cells from patients with leukocyte adhesion deficiency with an integrin beta subunit (CD18) restores lymphocyte function-associated antigen-1 expression and function. J Clin Invest. 1990 Mar; 85(3):674-81. PMID: 1968909; PMCID: PMC296482.
  368. Corbi AL, Garcia-Aguilar J, Springer TA. Genomic structure of an integrin alpha subunit, the leukocyte p150,95 molecule. J Biol Chem. 1990 Feb 15; 265(5):2782-8. PMID: 2303426.
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  369. Torres JH, Springer TA, Welch AJ, Pearce JA. Limitations of a thermal camera in measuring surface temperature of laser-irradiated tissues. Lasers Surg Med. 1990; 10(6):510-23. PMID: 2263150.
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  370. Springer TA. The sensation and regulation of interactions with the extracellular environment: the cell biology of lymphocyte adhesion receptors. Annu Rev Cell Biol. 1990; 6:359-402. PMID: 2275817.
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  371. Hibbs ML, Selvaraj P, Carpén O, Springer TA, Kuster H, Jouvin MH, Kinet JP. Mechanisms for regulating expression of membrane isoforms of Fc gamma RIII (CD16). Science. 1989 Dec 22; 246(4937):1608-11. PMID: 2531918.
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  372. Selvaraj P, Carpén O, Hibbs ML, Springer TA. Natural killer cell and granulocyte Fc gamma receptor III (CD16) differ in membrane anchor and signal transduction. J Immunol. 1989 Nov 15; 143(10):3283-8. PMID: 2553809.
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  373. Dustin ML, Springer TA. T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1. Nature. 1989 Oct 19; 341(6243):619-24. PMID: 2477710.
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  374. Budman SH, Soldz S, Demby A, Feldstein M, Springer T, Davis MS. Cohesion, alliance and outcome in group psychotherapy. Psychiatry. 1989 Aug; 52(3):339-50. PMID: 2772092.
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  375. Hollander N, Shin ML, Rosse WF, Springer TA. Distinct restriction of complement- and cell-mediated lysis. J Immunol. 1989 Jun 01; 142(11):3913-6. PMID: 2785570.
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  376. Staunton DE, Dustin ML, Springer TA. Functional cloning of ICAM-2, a cell adhesion ligand for LFA-1 homologous to ICAM-1. Nature. 1989 May 04; 339(6219):61-4. PMID: 2497351.
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  377. Staunton DE, Merluzzi VJ, Rothlein R, Barton R, Marlin SD, Springer TA. A cell adhesion molecule, ICAM-1, is the major surface receptor for rhinoviruses. Cell. 1989 Mar 10; 56(5):849-53. PMID: 2538244.
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  378. Kishimoto TK, O'Conner K, Springer TA. Leukocyte adhesion deficiency. Aberrant splicing of a conserved integrin sequence causes a moderate deficiency phenotype. J Biol Chem. 1989 Feb 25; 264(6):3588-95. PMID: 2464599.
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  379. Dustin ML, Olive D, Springer TA. Correlation of CD2 binding and functional properties of multimeric and monomeric lymphocyte function-associated antigen 3. J Exp Med. 1989 Feb 01; 169(2):503-17. PMID: 2463330; PMCID: PMC2189216.
  380. Tonnesen MG, Anderson DC, Springer TA, Knedler A, Avdi N, Henson PM. Adherence of neutrophils to cultured human microvascular endothelial cells. Stimulation by chemotactic peptides and lipid mediators and dependence upon the Mac-1, LFA-1, p150,95 glycoprotein family. J Clin Invest. 1989 Feb; 83(2):637-46. PMID: 2521491; PMCID: PMC303725.
  381. Larson RS, Corbi AL, Berman L, Springer T. Primary structure of the leukocyte function-associated molecule-1 alpha subunit: an integrin with an embedded domain defining a protein superfamily. J Cell Biol. 1989 Feb; 108(2):703-12. PMID: 2537322; PMCID: PMC2115430.
  382. Kishimoto TK, Springer TA. Human leukocyte adhesion deficiency: molecular basis for a defective immune response to infections of the skin. Curr Probl Dermatol. 1989; 18:106-15. PMID: 2663358.
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  383. Hale LP, Martin ME, McCollum DE, Nunley JA, Springer TA, Singer KH, Haynes BF. Immunohistologic analysis of the distribution of cell adhesion molecules within the inflammatory synovial microenvironment. Arthritis Rheum. 1989 Jan; 32(1):22-30. PMID: 2463839.
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  384. Kishimoto TK, Larson RS, Corbi AL, Dustin ML, Staunton DE, Springer TA. The leukocyte integrins. Adv Immunol. 1989; 46:149-82. PMID: 2551146.
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  385. Dustin ML, Garcia-Aguilar J, Hibbs ML, Larson RS, Stacker SA, Staunton DE, Wardlaw AJ, Springer TA. Structure and regulation of the leukocyte adhesion receptor LFA-1 and its counterreceptors, ICAM-1 and ICAM-2. Cold Spring Harb Symp Quant Biol. 1989; 54 Pt 2:753-65. PMID: 2577025.
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  386. Hollander N, Selvaraj P, Springer TA. Biosynthesis and function of LFA-3 in human mutant cells deficient in phosphatidylinositol-anchored proteins. J Immunol. 1988 Dec 15; 141(12):4283-90. PMID: 2461988.
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  387. Wang D, Liebowitz D, Wang F, Gregory C, Rickinson A, Larson R, Springer T, Kieff E. Epstein-Barr virus latent infection membrane protein alters the human B-lymphocyte phenotype: deletion of the amino terminus abolishes activity. J Virol. 1988 Nov; 62(11):4173-84. PMID: 2845129; PMCID: PMC253849.
  388. Denning SM, Dustin ML, Springer TA, Singer KH, Haynes BF. Purified lymphocyte function-associated antigen-3 (LFA-3) activates human thymocytes via the CD2 pathway. J Immunol. 1988 Nov 01; 141(9):2980-5. PMID: 2459236.
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  389. Mentzer SJ, Rothlein R, Springer TA, Faller DV. Intercellular adhesion molecule-1 (ICAM-1) is involved in the cytolytic T lymphocyte interaction with a human synovial cell line. J Cell Physiol. 1988 Oct; 137(1):173-8. PMID: 3049628.
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  390. Bockenstedt LK, Goldsmith MA, Dustin M, Olive D, Springer TA, Weiss A. The CD2 ligand LFA-3 activates T cells but depends on the expression and function of the antigen receptor. J Immunol. 1988 Sep 15; 141(6):1904-11. PMID: 2459194.
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  391. Corbi AL, Kishimoto TK, Miller LJ, Springer TA. The human leukocyte adhesion glycoprotein Mac-1 (complement receptor type 3, CD11b) alpha subunit. Cloning, primary structure, and relation to the integrins, von Willebrand factor and factor B. J Biol Chem. 1988 Sep 05; 263(25):12403-11. PMID: 2457584.
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  392. Dustin ML, Staunton DE, Springer TA. Supergene families meet in the immune system. Immunol Today. 1988 Jul-Aug; 9(7-8):213-5. PMID: 3076418.
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  393. Dustin ML, Springer TA. Lymphocyte function-associated antigen-1 (LFA-1) interaction with intercellular adhesion molecule-1 (ICAM-1) is one of at least three mechanisms for lymphocyte adhesion to cultured endothelial cells. J Cell Biol. 1988 Jul; 107(1):321-31. PMID: 3134364; PMCID: PMC2115164.
  394. Selvaraj P, Rosse WF, Silber R, Springer TA. The major Fc receptor in blood has a phosphatidylinositol anchor and is deficient in paroxysmal nocturnal haemoglobinuria. Nature. 1988 Jun 09; 333(6173):565-7. PMID: 2967435.
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  395. Corbi AL, Larson RS, Kishimoto TK, Springer TA, Morton CC. Chromosomal location of the genes encoding the leukocyte adhesion receptors LFA-1, Mac-1 and p150,95. Identification of a gene cluster involved in cell adhesion. J Exp Med. 1988 May 01; 167(5):1597-607. PMID: 3284962; PMCID: PMC2188934.
  396. Dustin ML, Singer KH, Tuck DT, Springer TA. Adhesion of T lymphoblasts to epidermal keratinocytes is regulated by interferon gamma and is mediated by intercellular adhesion molecule 1 (ICAM-1). J Exp Med. 1988 Apr 01; 167(4):1323-40. PMID: 3128630; PMCID: PMC2188928.
  397. Makgoba MW, Sanders ME, Ginther Luce GE, Gugel EA, Dustin ML, Springer TA, Shaw S. Functional evidence that intercellular adhesion molecule-1 (ICAM-1) is a ligand for LFA-1-dependent adhesion in T cell-mediated cytotoxicity. Eur J Immunol. 1988 Apr; 18(4):637-40. PMID: 2896596.
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  398. Staunton DE, Marlin SD, Stratowa C, Dustin ML, Springer TA. Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families. Cell. 1988 Mar 25; 52(6):925-33. PMID: 3349522.
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  399. Cotran RS, Pober JS, Gimbrone MA, Springer TA, Wiebke EA, Gaspari AA, Rosenberg SA, Lotze MT. Endothelial activation during interleukin 2 immunotherapy. A possible mechanism for the vascular leak syndrome. J Immunol. 1988 Mar 15; 140(6):1883-8. PMID: 3279124.
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  400. Sanders ME, Makgoba MW, Sharrow SO, Stephany D, Springer TA, Young HA, Shaw S. Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-gamma production. J Immunol. 1988 Mar 01; 140(5):1401-7. PMID: 2894392.
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  401. Makgoba MW, Sanders ME, Ginther Luce GE, Dustin ML, Springer TA, Clark EA, Mannoni P, Shaw S. ICAM-1 a ligand for LFA-1-dependent adhesion of B, T and myeloid cells. Nature. 1988 Jan 07; 331(6151):86-8. PMID: 3277059.
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  402. Budman SH, Demby A, Redondo JP, Hannan M, Feldstein M, Ring J, Springer T. Comparative outcome in time-limited individual and group psychotherapy. Int J Group Psychother. 1988 Jan; 38(1):63-86. PMID: 3280505.
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  403. Fischer A, Lisowska-Grospierre B, Anderson DC, Springer TA. Leukocyte adhesion deficiency: molecular basis and functional consequences. Immunodefic Rev. 1988; 1(1):39-54. PMID: 3078709.
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  404. Corbi AL, Miller LJ, O'Connor K, Larson RS, Springer TA. cDNA cloning and complete primary structure of the alpha subunit of a leukocyte adhesion glycoprotein, p150,95. EMBO J. 1987 Dec 20; 6(13):4023-8. PMID: 3327687; PMCID: PMC553883.
  405. Marlin SD, Springer TA. Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1). Cell. 1987 Dec 04; 51(5):813-9. PMID: 3315233.
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  406. Bainton DF, Miller LJ, Kishimoto TK, Springer TA. Leukocyte adhesion receptors are stored in peroxidase-negative granules of human neutrophils. J Exp Med. 1987 Dec 01; 166(6):1641-53. PMID: 2824654; PMCID: PMC2188781.
  407. Tiefenthaler G, Hünig T, Dustin ML, Springer TA, Meuer SC. Purified lymphocyte function-associated antigen-3 and T11 target structure are active in CD2-mediated T cell stimulation. Eur J Immunol. 1987 Dec; 17(12):1847-50. PMID: 2891540.
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  408. Selvaraj P, Dustin ML, Mitnacht R, Hünig T, Springer TA, Plunkett ML. Rosetting of human T lymphocytes with sheep and human erythrocytes. Comparison of human and sheep ligand binding using purified E receptor. J Immunol. 1987 Oct 15; 139(8):2690-5. PMID: 3309056.
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  409. Tiefenthaler G, Dustin ML, Springer TA, Hünig T. Serologic cross-reactivity of T11 target structure and lymphocyte function-associated antigen 3. Evidence for structural homology of the sheep and human ligands of CD2. J Immunol. 1987 Oct 15; 139(8):2696-701. PMID: 2443569.
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  410. Denning SM, Tuck DT, Vollger LW, Springer TA, Singer KH, Haynes BF. Monoclonal antibodies to CD2 and lymphocyte function-associated antigen 3 inhibit human thymic epithelial cell-dependent mature thymocyte activation. J Immunol. 1987 Oct 15; 139(8):2573-8. PMID: 3116085.
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  411. Dustin ML, Selvaraj P, Mattaliano RJ, Springer TA. Anchoring mechanisms for LFA-3 cell adhesion glycoprotein at membrane surface. Nature. 1987 Oct 29-Nov 4; 329(6142):846-8. PMID: 3313053.
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  412. Selvaraj P, Dustin ML, Silber R, Low MG, Springer TA. Deficiency of lymphocyte function-associated antigen 3 (LFA-3) in paroxysmal nocturnal hemoglobinuria. Functional correlates and evidence for a phosphatidylinositol membrane anchor. J Exp Med. 1987 Oct 01; 166(4):1011-25. PMID: 3309123; PMCID: PMC2188732.
  413. Wallner BP, Frey AZ, Tizard R, Mattaliano RJ, Hession C, Sanders ME, Dustin ML, Springer TA. Primary structure of lymphocyte function-associated antigen 3 (LFA-3). The ligand of the T lymphocyte CD2 glycoprotein. J Exp Med. 1987 Oct 01; 166(4):923-32. PMID: 3309127; PMCID: PMC2188720.
  414. Borregaard N, Miller LJ, Springer TA. Chemoattractant-regulated mobilization of a novel intracellular compartment in human neutrophils. Science. 1987 Sep 04; 237(4819):1204-6. PMID: 3629236.
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  415. Miller LJ, Springer TA. Biosynthesis and glycosylation of p150,95 and related leukocyte adhesion proteins. J Immunol. 1987 Aug 01; 139(3):842-7. PMID: 3298434.
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  416. Miller LJ, Bainton DF, Borregaard N, Springer TA. Stimulated mobilization of monocyte Mac-1 and p150,95 adhesion proteins from an intracellular vesicular compartment to the cell surface. J Clin Invest. 1987 Aug; 80(2):535-44. PMID: 3038962; PMCID: PMC442267.
  417. Kishimoto TK, Hollander N, Roberts TM, Anderson DC, Springer TA. Heterogeneous mutations in the beta subunit common to the LFA-1, Mac-1, and p150,95 glycoproteins cause leukocyte adhesion deficiency. Cell. 1987 Jul 17; 50(2):193-202. PMID: 3594570.
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  418. Pischel KD, Marlin SD, Springer TA, Woods VL, Bluestein HG. Polymorphism of lymphocyte function-associated antigen-1 demonstrated by a lupus patient's alloantiserum. J Clin Invest. 1987 Jun; 79(6):1607-14. PMID: 2438304; PMCID: PMC424480.
  419. Pober JS, Lapierre LA, Stolpen AH, Brock TA, Springer TA, Fiers W, Bevilacqua MP, Mendrick DL, Gimbrone MA. Activation of cultured human endothelial cells by recombinant lymphotoxin: comparison with tumor necrosis factor and interleukin 1 species. J Immunol. 1987 May 15; 138(10):3319-24. PMID: 3494766.
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  420. Miller LJ, Wiebe M, Springer TA. Purification and alpha subunit N-terminal sequences of human Mac-1 and p150,95 leukocyte adhesion proteins. J Immunol. 1987 Apr 15; 138(8):2381-3. PMID: 3549901.
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  421. Wertlieb D, Weigel C, Springer T, Feldstein M. Temperament as a moderator of children's stressful experiences. Am J Orthopsychiatry. 1987 Apr; 57(2):234-45. PMID: 3591908.
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  422. Plunkett ML, Sanders ME, Selvaraj P, Dustin ML, Springer TA. Rosetting of activated human T lymphocytes with autologous erythrocytes. Definition of the receptor and ligand molecules as CD2 and lymphocyte function-associated antigen 3 (LFA-3). J Exp Med. 1987 Mar 01; 165(3):664-76. PMID: 3102675; PMCID: PMC2188280.
  423. Dustin ML, Sanders ME, Shaw S, Springer TA. Purified lymphocyte function-associated antigen 3 binds to CD2 and mediates T lymphocyte adhesion. J Exp Med. 1987 Mar 01; 165(3):677-92. PMID: 3102676; PMCID: PMC2188278.
  424. Selvaraj P, Plunkett ML, Dustin M, Sanders ME, Shaw S, Springer TA. The T lymphocyte glycoprotein CD2 binds the cell surface ligand LFA-3. Nature. 1987 Mar 26-Apr 1; 326(6111):400-3. PMID: 2951597.
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  425. Kishimoto TK, O'Connor K, Lee A, Roberts TM, Springer TA. Cloning of the beta subunit of the leukocyte adhesion proteins: homology to an extracellular matrix receptor defines a novel supergene family. Cell. 1987 Feb 27; 48(4):681-90. PMID: 3028646.
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  426. Vollger LW, Tuck DT, Springer TA, Haynes BF, Singer KH. Thymocyte binding to human thymic epithelial cells is inhibited by monoclonal antibodies to CD-2 and LFA-3 antigens. J Immunol. 1987 Jan 15; 138(2):358-63. PMID: 3098838.
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  427. Anderson DC, Springer TA. Leukocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1, and p150,95 glycoproteins. Annu Rev Med. 1987; 38:175-94. PMID: 3555290.
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  428. Springer TA, Dustin ML, Kishimoto TK, Marlin SD. The lymphocyte function-associated LFA-1, CD2, and LFA-3 molecules: cell adhesion receptors of the immune system. Annu Rev Immunol. 1987; 5:223-52. PMID: 3109455.
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  429. Haskard D, Cavender D, Beatty P, Springer T, Ziff M. T lymphocyte adhesion to endothelial cells: mechanisms demonstrated by anti-LFA-1 monoclonal antibodies. J Immunol. 1986 Nov 01; 137(9):2901-6. PMID: 2428877.
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  430. Miller LJ, Schwarting R, Springer TA. Regulated expression of the Mac-1, LFA-1, p150,95 glycoprotein family during leukocyte differentiation. J Immunol. 1986 Nov 01; 137(9):2891-900. PMID: 2428876.
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  431. Mentzer SJ, Bierer BE, Anderson DC, Springer TA, Burakoff SJ. Abnormal cytolytic activity of lymphocyte function-associated antigen-1-deficient human cytolytic T lymphocyte clones. J Clin Invest. 1986 Nov; 78(5):1387-91. PMID: 3534001; PMCID: PMC423840.
  432. Pober JS, Gimbrone MA, Lapierre LA, Mendrick DL, Fiers W, Rothlein R, Springer TA. Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon. J Immunol. 1986 Sep 15; 137(6):1893-6. PMID: 3091693.
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  433. Shaw S, Luce GE, Quinones R, Gress RE, Springer TA, Sanders ME. Two antigen-independent adhesion pathways used by human cytotoxic T-cell clones. Nature. 1986 Sep 18-24; 323(6085):262-4. PMID: 3093887.
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  434. Marlin SD, Morton CC, Anderson DC, Springer TA. LFA-1 immunodeficiency disease. Definition of the genetic defect and chromosomal mapping of alpha and beta subunits of the lymphocyte function-associated antigen 1 (LFA-1) by complementation in hybrid cells. J Exp Med. 1986 Sep 01; 164(3):855-67. PMID: 3528378; PMCID: PMC2188389.
  435. Rothlein R, Dustin ML, Marlin SD, Springer TA. A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1. J Immunol. 1986 Aug 15; 137(4):1270-4. PMID: 3525675.
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  436. Sastre L, Roman JM, Teplow DB, Dreyer WJ, Gee CE, Larson RS, Roberts TM, Springer TA. A partial genomic DNA clone for the alpha subunit of the mouse complement receptor type 3 and cellular adhesion molecule Mac-1. Proc Natl Acad Sci U S A. 1986 Aug; 83(15):5644-8. PMID: 2942940; PMCID: PMC386345.
  437. Sastre L, Kishimoto TK, Gee C, Roberts T, Springer TA. The mouse leukocyte adhesion proteins Mac-1 and LFA-1: studies on mRNA translation and protein glycosylation with emphasis on Mac-1. J Immunol. 1986 Aug 01; 137(3):1060-5. PMID: 3522736.
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  438. Gee CE, Griffin J, Sastre L, Miller LJ, Springer TA, Piwnica-Worms H, Roberts TM. Differentiation of myeloid cells is accompanied by increased levels of pp60c-src protein and kinase activity. Proc Natl Acad Sci U S A. 1986 Jul; 83(14):5131-5. PMID: 2425362; PMCID: PMC323904.
  439. Anderson DC, Miller LJ, Schmalstieg FC, Rothlein R, Springer TA. Contributions of the Mac-1 glycoprotein family to adherence-dependent granulocyte functions: structure-function assessments employing subunit-specific monoclonal antibodies. J Immunol. 1986 Jul 01; 137(1):15-27. PMID: 3519773.
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  440. Dustin ML, Rothlein R, Bhan AK, Dinarello CA, Springer TA. Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J Immunol. 1986 Jul 01; 137(1):245-54. PMID: 3086451.
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  441. Plunkett ML, Springer TA. Purification and characterization of the lymphocyte function-associated-2 (LFA-2) molecule. J Immunol. 1986 Jun 01; 136(11):4181-7. PMID: 3517166.
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  442. Strassmann G, Springer TA, Somers SD, Adams DO. Mechanisms of tumor cell capture by activated macrophages: evidence for involvement of lymphocyte function-associated (LFA)-1 antigen. J Immunol. 1986 Jun 01; 136(11):4328-33. PMID: 2422281.
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  443. Rothlein R, Springer TA. The requirement for lymphocyte function-associated antigen 1 in homotypic leukocyte adhesion stimulated by phorbol ester. J Exp Med. 1986 May 01; 163(5):1132-49. PMID: 3517218; PMCID: PMC2188099.
  444. Cardosa MJ, Gordon S, Hirsch S, Springer TA, Porterfield JS. Interaction of West Nile virus with primary murine macrophages: role of cell activation and receptors for antibody and complement. J Virol. 1986 Mar; 57(3):952-9. PMID: 3951020; PMCID: PMC252826.
  445. Lisowska-Grospierre B, Bohler MC, Fischer A, Mawas C, Springer TA, Giscelli C. Defective membrane expression of the LFA-1 complex may be secondary to the absence of the beta chain in a child with recurrent bacterial infection. Eur J Immunol. 1986 Feb; 16(2):205-8. PMID: 3514236.
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  446. Sanchez-Madrid F, Springer TA. Production of Syrian and Armenian hamster monoclonal antibodies of defined specificity. Methods Enzymol. 1986; 121:239-44. PMID: 3724464.
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  447. Springer TA, Miller LJ, Anderson DC. p150,95, the third member of the Mac-1, LFA-1 human leukocyte adhesion glycoprotein family. J Immunol. 1986 Jan; 136(1):240-5. PMID: 3510003.
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  448. Strassmann G, Somers SD, Springer TA, Adams DO, Hamilton TA. Biochemical models of interferon-gamma-mediated macrophage activation: independent regulation of lymphocyte function associated antigen (LFA)-1 and I-A antigen on murine peritoneal macrophages. Cell Immunol. 1986 Jan; 97(1):110-20. PMID: 3017574.
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  449. Springer TA, Anderson DC. The importance of the Mac-1, LFA-1 glycoprotein family in monocyte and granulocyte adherence, chemotaxis, and migration into inflammatory sites: insights from an experiment of nature. Ciba Found Symp. 1986; 118:102-26. PMID: 3525036.
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  450. Springer TA, Anderson DC. Leukocyte complement receptors and adhesion proteins in the inflammatory response: insights from an experiment of nature. Biochem Soc Symp. 1986; 51:47-57. PMID: 2949749.
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  451. Krensky AM, Mentzer SJ, Clayberger C, Anderson DC, Schmalstieg FC, Burakoff SJ, Springer TA. Heritable lymphocyte function-associated antigen-1 deficiency: abnormalities of cytotoxicity and proliferation associated with abnormal expression of LFA-1. J Immunol. 1985 Nov; 135(5):3102-8. PMID: 3900204.
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  452. Rothlein R, Springer TA. Complement receptor type three-dependent degradation of opsonized erythrocytes by mouse macrophages. J Immunol. 1985 Oct; 135(4):2668-72. PMID: 3897377.
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  453. Ross GD, Thompson RA, Walport MJ, Springer TA, Watson JV, Ward RH, Lida J, Newman SL, Harrison RA, Lachmann PJ. Characterization of patients with an increased susceptibility to bacterial infections and a genetic deficiency of leukocyte membrane complement receptor type 3 and the related membrane antigen LFA-1. Blood. 1985 Oct; 66(4):882-90. PMID: 3899217.
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  454. Strassmann G, Springer TA, Haskill SJ, Miraglia CC, Lanier LL, Adams DO. Antigens associated with the activation of murine mononuclear phagocytes in vivo: differential expression of lymphocyte function-associated antigen in the several stages of development. Cell Immunol. 1985 Aug; 94(1):265-75. PMID: 3893748.
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  455. Gaulton GN, Bangs J, Maddock S, Springer T, Eardley DD, Strom TB. Characterization of a monoclonal rat anti-mouse interleukin 2 (IL-2) receptor antibody and its use in the biochemical characterization of the murine IL-2 receptor. Clin Immunol Immunopathol. 1985 Jul; 36(1):18-29. PMID: 3924455.
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  456. Anderson DC, Schmalstieg FC, Shearer W, Becker-Freeman K, Kohl S, Smith CW, Tosi MF, Springer T. Leukocyte LFA-1, OKM1, p150,95 deficiency syndrome: functional and biosynthetic studies of three kindreds. Fed Proc. 1985 Jul; 44(10):2671-7. PMID: 3891420.
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  457. Strassmann G, Springer TA, Adams DO. Studies on antigens associated with the activation of murine mononuclear phagocytes: kinetics of and requirements for induction of lymphocyte function-associated (LFA)-1 antigen in vitro. J Immunol. 1985 Jul; 135(1):147-51. PMID: 3923098.
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  458. Springer TA. The LFA-1, Mac-1 glycoprotein family and its deficiency in an inherited disease. Fed Proc. 1985 Jul; 44(10):2660-3. PMID: 3891418.
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  459. Shaw S, Goldstein G, Springer TA, Biddison WE. Susceptibility of cytotoxic T lymphocyte (CTL) clones to inhibition by anti-T3 and anti-T4 (but not anti-LFA-1) monoclonal antibodies varies with the "avidity" of CTL-target interaction. J Immunol. 1985 May; 134(5):3019-26. PMID: 2580011.
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  460. Miller BA, Antognetti G, Springer TA. Identification of cell surface antigens present on murine hematopoietic stem cells. J Immunol. 1985 May; 134(5):3286-90. PMID: 3980993.
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  461. Springer TA, Teplow DB, Dreyer WJ. Sequence homology of the LFA-1 and Mac-1 leukocyte adhesion glycoproteins and unexpected relation to leukocyte interferon. Nature. 1985 Apr 11-17; 314(6011):540-2. PMID: 3887182.
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  462. Springer TA, Sastre L, Anderson DC. The LFA-1, Mac-1 leucocyte adhesion glycoprotein family and its deficiency in a heritable human disease. Biochem Soc Trans. 1985 Feb; 13(1):3-6. PMID: 3888720.
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  463. Springer TA, Rothlein R, Anderson DC, Burakoff SJ, Krensky AM. The function of LFA-1 in cell-mediated killing and adhesion: studies on heritable LFA-1, Mac-1 deficiency and on lymphoid cell self-aggregation. Adv Exp Med Biol. 1985; 184:311-22. PMID: 3898754.
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  464. Hogarth PM, Walker ID, McKenzie IF, Springer TA. The Ly-15 alloantigenic system: a genetically determined polymorphism of the murine lymphocyte function-associated antigen-1 molecule. Proc Natl Acad Sci U S A. 1985 Jan; 82(2):526-30. PMID: 3881766; PMCID: PMC397072.
  465. Kohl S, Springer TA, Schmalstieg FC, Loo LS, Anderson DC. Defective natural killer cytotoxicity and polymorphonuclear leukocyte antibody-dependent cellular cytotoxicity in patients with LFA-1/OKM-1 deficiency. J Immunol. 1984 Dec; 133(6):2972-8. PMID: 6092461.
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  466. Springer TA, Thompson WS, Miller LJ, Schmalstieg FC, Anderson DC. Inherited deficiency of the Mac-1, LFA-1, p150,95 glycoprotein family and its molecular basis. J Exp Med. 1984 Dec 01; 160(6):1901-18. PMID: 6096477; PMCID: PMC2187528.
  467. Hemler ME, Sanchez-Madrid F, Flotte TJ, Krensky AM, Burakoff SJ, Bhan AK, Springer TA, Strominger JL. Glycoproteins of 210,000 and 130,000 m.w. on activated T cells: cell distribution and antigenic relation to components on resting cells and T cell lines. J Immunol. 1984 Jun; 132(6):3011-8. PMID: 6327814.
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  468. Krensky AM, Robbins E, Springer TA, Burakoff SJ. LFA-1, LFA-2, and LFA-3 antigens are involved in CTL-target conjugation. J Immunol. 1984 May; 132(5):2180-2. PMID: 6201533.
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  469. Ho MK, Springer TA. Preparation and use of monoclonal antimacrophage antibodies. Methods Enzymol. 1984; 108:313-24. PMID: 6084796.
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  470. Dana N, Todd RF, Pitt J, Springer TA, Arnaout MA. Deficiency of a surface membrane glycoprotein (Mo1) in man. J Clin Invest. 1984 Jan; 73(1):153-9. PMID: 6361068; PMCID: PMC424986.
  471. Krensky AM, Sanchez-Madrid F, Springer TA, Burakoff SJ. Human lymphocyte function-associated antigens. Surv Immunol Res. 1984; 3(1):39-44. PMID: 6371972.
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  472. Springer TA, Unkeless JC. Analysis of macrophage differentiation and function with monoclonal antibodies. Contemp Top Immunobiol. 1984; 13:1-31. PMID: 6375951.
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  473. Ralph P, Harris PE, Punjabi CJ, Welte K, Litcofsky PB, Ho MK, Rubin BY, Moore MA, Springer TA. Lymphokine inducing "terminal differentiation" of the human monoblast leukemia line U937: a role for gamma interferon. Blood. 1983 Dec; 62(6):1169-75. PMID: 6416332.
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  474. Sanchez-Madrid F, Nagy JA, Robbins E, Simon P, Springer TA. A human leukocyte differentiation antigen family with distinct alpha-subunits and a common beta-subunit: the lymphocyte function-associated antigen (LFA-1), the C3bi complement receptor (OKM1/Mac-1), and the p150,95 molecule. J Exp Med. 1983 Dec 01; 158(6):1785-1803. PMID: 6196430; PMCID: PMC2187169.
  475. Ware CF, Sanchez-Madrid F, Krensky AM, Burakoff SJ, Strominger JL, Springer TA. Human lymphocyte function associated antigen-1 (LFA-1): identification of multiple antigenic epitopes and their relationship to CTL-mediated cytotoxicity. J Immunol. 1983 Sep; 131(3):1182-8. PMID: 6193178.
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  476. Krensky AM, Sanchez-Madrid F, Robbins E, Nagy JA, Springer TA, Burakoff SJ. The functional significance, distribution, and structure of LFA-1, LFA-2, and LFA-3: cell surface antigens associated with CTL-target interactions. J Immunol. 1983 Aug; 131(2):611-6. PMID: 6345670.
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  477. Sanchez-Madrid F, Simon P, Thompson S, Springer TA. Mapping of antigenic and functional epitopes on the alpha- and beta-subunits of two related mouse glycoproteins involved in cell interactions, LFA-1 and Mac-1. J Exp Med. 1983 Aug 01; 158(2):586-602. PMID: 6193226; PMCID: PMC2187359.
  478. Mendrick DL, Rennke HG, Cotran RS, Springer TA, Abbas AK. Monoclonal antibodies against rat glomerular antigens: production and specificity. Lab Invest. 1983 Jul; 49(1):107-17. PMID: 6191120.
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  479. Haines KA, Flotte TJ, Springer TA, Gigli I, Thorbecke GJ. Staining of Langerhans cells with monoclonal antibodies to macrophages and lymphoid cells. Proc Natl Acad Sci U S A. 1983 Jun; 80(11):3448-51. PMID: 6574493; PMCID: PMC394061.
  480. Gromkowski SH, Heagy W, Sanchez-Madrid F, Springer TA, Martz E. Blocking of CTL-mediated killing by monoclonal antibodies to LFA-1 and LYT-2,3. I. Increased susceptibility to blocking after papain treatment of target cells. J Immunol. 1983 Jun; 130(6):2546-51. PMID: 6406593.
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  481. Flotte TJ, Springer TA, Thorbecke GJ. Dendritic cell and macrophage staining by monoclonal antibodies in tissue sections and epidermal sheets. Am J Pathol. 1983 Apr; 111(1):112-24. PMID: 6340516; PMCID: PMC1916197.
  482. Ho MK, Springer TA. Biosynthesis and assembly of the alpha and beta subunits of Mac-1, a macrophage glycoprotein associated with complement receptor function. J Biol Chem. 1983 Mar 10; 258(5):2766-9. PMID: 6338004.
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  483. Baldwin WM, Claas FH, Paul LC, Springer TA, Hendriks GF, van Es LA, van Rood JJ. All monocyte antigens are not expressed on renal endothelium. Tissue Antigens. 1983 Mar; 21(3):254-9. PMID: 6344322.
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  484. Ho MK, Springer TA. Tissue distribution, structural characterization, and biosynthesis of Mac-3, a macrophage surface glycoprotein exhibiting molecular weight heterogeneity. J Biol Chem. 1983 Jan 10; 258(1):636-42. PMID: 6336756.
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  485. Sanchez-Madrid F, Szklut P, Springer TA. Stable hamster-mouse hybridomas producing IgG and IgM hamster monoclonal antibodies of defined specificity. J Immunol. 1983 Jan; 130(1):309-12. PMID: 6847883.
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  486. Ralph P, Ho MK, Litcofsky PB, Springer TA. Expression and induction in vitro of macrophage differentiation antigens on murine cell lines. J Immunol. 1983 Jan; 130(1):108-14. PMID: 6847876.
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  487. Springer TA. Quantitation of hybridoma immunoglobulins and selection of light-chain loss variants. Methods Enzymol. 1983; 92:147-60. PMID: 6406793.
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  488. Burakoff SJ, Clayberger C, Hemler M, Krensky AM, Reiss CS, Robbins E, Sanchez-Madrid F, Springer TA, Strominger JL, Ware CF. Cytotoxic T cells directed against HLA-DR antigens and their surface proteins. Diagn Immunol. 1983; 1(3):116-9. PMID: 6238749.
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  489. Sanchez-Madrid F, Krensky AM, Ware CF, Robbins E, Strominger JL, Burakoff SJ, Springer TA. Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3. Proc Natl Acad Sci U S A. 1982 Dec; 79(23):7489-93. PMID: 6984191; PMCID: PMC347365.
  490. Kaufmann Y, Golstein P, Pierres M, Springer TA, Eshhar Z. LFA-1 but not Lyt-2 is associated with killing activity of cytotoxic T lymphocyte hybridomas. Nature. 1982 Nov 25; 300(5890):357-60. PMID: 6983035.
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  491. Kürzinger K, Springer TA. Purification and structural characterization of LFA-1, a lymphocyte function-associated antigen, and Mac-1, a related macrophage differentiation antigen associated with the type three complement receptor. J Biol Chem. 1982 Oct 25; 257(20):12412-8. PMID: 6749860.
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  492. Sanchez-Madrid F, Davignon D, Martz E, Springer TA. Antigens involved in mouse cytolytic T-lymphocyte (CTL)-mediated killing: functional screening and topographic relationship. Cell Immunol. 1982 Oct; 73(1):1-11. PMID: 6983917.
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  493. Beller DI, Springer TA, Schreiber RD. Anti-Mac-1 selectively inhibits the mouse and human type three complement receptor. J Exp Med. 1982 Oct 01; 156(4):1000-9. PMID: 7153706; PMCID: PMC2186827.
  494. Springer TJ. Emphasizes ergonomics of office automation. Natl Underwrit Life Health. 1982 Sep 25; 86(39):22-3. PMID: 10257625.
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  495. Weinberger O, Germain RN, Springer T, Burakoff SJ. Role of syngeneic Ia+ accessory cells in the generation of allospecific CTL responses. J Immunol. 1982 Aug; 129(2):694-7. PMID: 6979580.
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  496. Ho MK, Springer TA. Mac-1 antigen: quantitative expression in macrophage populations and tissues, and immunofluorescent localization in spleen. J Immunol. 1982 May; 128(5):2281-6. PMID: 7037963.
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  497. Kürzinger K, Ho MK, Springer TA. Structural homology of a macrophage differentiation antigen and an antigen involved in T-cell-mediated killing. Nature. 1982 Apr 15; 296(5858):668-70. PMID: 6175907.
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  498. Germain RN, Bhattacharya A, Dorf ME, Springer TA. A single monoclonal anti-Ia antibody inhibits antigen-specific T cell proliferation controlled by distinct Ir genes mapping in different H-2 I subregions. J Immunol. 1982 Mar; 128(3):1409-13. PMID: 6173436.
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  499. Ho MK, Springer TA. Mac-2, a novel 32,000 Mr mouse macrophage subpopulation-specific antigen defined by monoclonal antibodies. J Immunol. 1982 Mar; 128(3):1221-8. PMID: 6173426.
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  500. Martz E, Davignon D, Kürzinger K, Springer TA. The molecular basis for cytolytic T lymphocyte function: analysis with blocking monoclonal antibodies. Adv Exp Med Biol. 1982; 146:447-68. PMID: 6980570.
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  501. Springer TA, Davignon D, Ho MK, Kürzinger K, Martz E, Sanchez-Madrid F. LFA-1 and Lyt-2,3, molecules associated with T lymphocyte-mediated killing; and Mac-1, an LFA-1 homologue associated with complement receptor function. Immunol Rev. 1982; 68:171-95. PMID: 6184305.
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  502. Springer TA, Bhattacharya A, Cardoza JT, Sanchez-Madrid F. Monoclonal antibodies specific for rat IgG1, IgG2a, and IgG2b subclasses, and kappa chain monotypic and allotypic determinants: reagents for use with rat monoclonal antibodies. Hybridoma. 1982; 1(3):257-73. PMID: 6208128.
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  503. Bhattacharya A, Dorf ME, Springer TA. A shared alloantigenic determinant on Ia antigens encoded by the I-A and I-E subregions: evidence for I region gene duplication. J Immunol. 1981 Dec; 127(6):2488-95. PMID: 6170707.
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  504. Holmberg LA, Springer TA, Ault KA. Natural killer activity in the peritoneal exudates of mice infected with Listeria monocytogenes: characterization of the natural killer cells by using a monoclonal rat anti-murine macrophage antibody (M1/70). J Immunol. 1981 Nov; 127(5):1792-9. PMID: 6795262.
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  505. Stallcup KC, Springer TA, Mescher MF. Characterization of an anti-H-2 monoclonal antibody and its use in large-scale antigen purification. J Immunol. 1981 Sep; 127(3):923-30. PMID: 6167633.
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  506. Davignon D, Martz E, Reynolds T, Kürzinger K, Springer TA. Monoclonal antibody to a novel lymphocyte function-associated antigen (LFA-1): mechanism of blockade of T lymphocyte-mediated killing and effects on other T and B lymphocyte functions. J Immunol. 1981 Aug; 127(2):590-5. PMID: 6166678.
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  507. Kürzinger K, Reynolds T, Germain RN, Davignon D, Martz E, Springer TA. A novel lymphocyte function-associated antigen (LFA-1): cellular distribution, quantitative expression, and structure. J Immunol. 1981 Aug; 127(2):596-602. PMID: 6788846.
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  508. Davignon D, Martz E, Reynolds T, Kürzinger K, Springer TA. Lymphocyte function-associated antigen 1 (LFA-1): a surface antigen distinct from Lyt-2,3 that participates in T lymphocyte-mediated killing. Proc Natl Acad Sci U S A. 1981 Jul; 78(7):4535-9. PMID: 7027264; PMCID: PMC319826.
  509. Springer TA. Monoclonal antibody analysis of complex biological systems. Combination of cell hybridization and immunoadsorbents in a novel cascade procedure and its application to the macrophage cell surface. J Biol Chem. 1981 Apr 25; 256(8):3833-9. PMID: 7217058.
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  510. Takei F, Secher DS, Milstein C, Springer T. Use of a monoclonal antibody specifically non-reactive with T cells to delineate lymphocyte subpopulations. Immunology. 1981 Mar; 42(3):371-8. PMID: 7009413; PMCID: PMC1458466.
  511. Ault KA, Springer TA. Cross-reaction of a rat-anti-mouse phagocyte-specific monoclonal antibody (anti-Mac-1) with human monocytes and natural killer cells. J Immunol. 1981 Jan; 126(1):359-64. PMID: 7451976.
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  512. Springer TA. Quantitation of light chain synthesis in myeloma x spleen cell hybrids and identification of myeloma chain loss variants using radioimmunoassay. J Immunol Methods. 1980; 37(2):139-52. PMID: 6777428.
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  513. Milstein C, Galfre G, Secher DS, Springer T. Monoclonal antibodies and cell surface antigens. Ciba Found Symp. 1979 Jun 27-29; (66):251-76. PMID: 258170.
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  514. Springer T, Galfré G, Secher DS, Milstein C. Mac-1: a macrophage differentiation antigen identified by monoclonal antibody. Eur J Immunol. 1979 Apr; 9(4):301-6. PMID: 89034.
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  515. Milstein C, Galfre G, Secher DS, Springer T. Monoclonal antibodies and cell surface antigens. Cell Biol Int Rep. 1979 Jan; 3(1):1-16. PMID: 88272.
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  516. Springer T, Galfrè G, Secher DS, Milstein C. Monoclonal xenogeneic antibodies to murine cell surface antigens: identification of novel leukocyte differentiation antigens. Eur J Immunol. 1978 Aug; 8(8):539-51. PMID: 81133.
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  517. Springer T, Galfre G, Secher D, Milstein C. Monoclonal xenogeneic antibodies to mouse leukocyte antigens: identification of macrophage-specific and other differentiation antigens. Curr Top Microbiol Immunol. 1978; 81:45-50. PMID: 688760.
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  518. Springer TA, Kaufman JF, Siddoway LA, Mann DL, Strominger JL. Purification of HLA-linked B lymphocyte alloantigens in immunologically active form by preparative sodium dodecyl sulfate-gel electrophoresis and studies on their subunit association. J Biol Chem. 1977 Sep 10; 252(17):6201-7. PMID: 302259.
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  519. Springer TA, Kaufman JF, Terhorst C, Strominger JL. Purification and structural characterisation of human HLA-linked B-cell antigens. Nature. 1977 Jul 21; 268(5617):213-8. PMID: 301990.
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  520. Springer TA, Mann DL, DeFranco AL, Strominger JL. Detergent solubilization, purification, and separation of specificities of HLA antigens from a cultured human lymphoblastoid line, RPMI 4265. J Biol Chem. 1977 Jul 10; 252(13):4682-93. PMID: 68955.
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  521. Springer TA, Robb RJ, Terhorst C, Strominger JL. Submit and disulfide structure of monomeric and dimeric forms of detergent-soluble HLA antigens. J Biol Chem. 1977 Jul 10; 252(13):4694-700. PMID: 873911.
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  522. Springer TA, Strominger JL. Detergent-soluble products of the HLA region. Transplant Proc. 1977 Mar; 9(1 Suppl 1):21-8. PMID: 300928.
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  523. Springer TA, Kaufman JF, Siddoway LA, Giphart M, Mann DL, Terhorst C, Strominger JL. Chemical and immunological characterization of HL-A linked B-lymphocyte alloantigens. Cold Spring Harb Symp Quant Biol. 1977; 41 Pt 1:387-96. PMID: 70316.
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  524. Strominger JL, Mann DL, Parham P, Robb R, Springer T, Terhorst C. Structure of HL-A A and B antigens isolated from cultured human lymphocytes. Cold Spring Harb Symp Quant Biol. 1977; 41 Pt 1:323-9. PMID: 330091.
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  525. Simpson-Herren L, Sanford AH, Holmquist JP, Springer TA, Lloyd HH. Ambiguity of the thymidine index. Cancer Res. 1976 Dec; 36(12):4705-9. PMID: 1000512.
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  526. Springer TA, Strominger JL. Detergent-soluble HLA antigens contain a hydrophilic region at the COOH-terminus and a penultimate hydrophobic region. Proc Natl Acad Sci U S A. 1976 Jul; 73(7):2481-5. PMID: 781677; PMCID: PMC430616.
  527. Strominger JL, Humphreys RE, McCune JM, Parham P, Robb R, Springer T, Terhorst C. The immunoglobulin-like structure of human histocompatibility antigens. Fed Proc. 1976 Apr; 35(5):1177-82. PMID: 57071.
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  528. Cresswell P, Springer T, Strominger JL, Turner MJ, Grey HM, Kubo RT. Immunological identity of the small subunit of HL-A antigens and beta2-microglobulin and its turnover on the cell membrane. Proc Natl Acad Sci U S A. 1974 May; 71(5):2123-7. PMID: 4134761; PMCID: PMC388399.
  529. Springer TA, Strominger JL, Mann D. Partial purification of detergent-soluble HL-A antigen and its cleavage by papain. Proc Natl Acad Sci U S A. 1974 Apr; 71(4):1539-43. PMID: 4208551; PMCID: PMC388266.
  530. Springer TD, Fishbone G, Shapiro R. Persistent hypoglossal artery associated with superior cerebellar artery aneurysm. Case report. J Neurosurg. 1974 Mar; 40(3):297-9. PMID: 4813711.
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  531. Strominger JL, Cresswell P, Grey H, Humphreys RE, Mann D, Parham P, Robb R, Sanderson AR, Springer TA, Terhorst C, Turner MJ. The immunoglobulin-like structure of human histocompatibility antigens. Transplant Rev. 1974; 21(0):126-43. PMID: 4139785.
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  532. Grey HM, Kubo RT, Colon SM, Poulik MD, Cresswell P, Springer T, Turner M, Strominger JL. The small subunit of HL-A antigens is beta 2-microglobulin. J Exp Med. 1973 Dec 01; 138(6):1608-12. PMID: 4128442; PMCID: PMC2139471.
  533. Maier-Leibnitz H, Springer T. Production and use of thermal reactor neutron beams. Annu Rev Nucl Sci. 1966; 16:207-62. PMID: 5334732.
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  534. HORWITZ T, MORROW RE, SPRINGER TR. An experimental study of transplantation of preserved homogenous articular cartilage in dogs. Surg Gynecol Obstet. 1959 Jul; 109(1):67-72. PMID: 13668840.
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