Harvard Catalyst Profiles

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Lei Liu, Ph.D., M.D.

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Harbin Medical UniversityMD07/2009Clinical Medicine
Shiga University of Medical SciencePhD10/2014Dementia

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. PIN Pilot Project (LIU, LEI) Sep 1, 2021 - Aug 31, 2022
    Program for Interdisciplinary Neuroscience/Brigham and Women's Hospital
    Understanding tau protein complexity in Alzheimer’s disease brains
    Role: Principle Investigator
  2. Development Projects (LIU, LEI) Apr 1, 2020 - Mar 31, 2021
    Massachusetts Alzheimer's Disease Research Center
    Understanding tau protein complexity in plasma via novel ultra-sensitive immunoassays
    Role Description: We plan to accurately measure a panel of tau species in plasma, as alterations of tau in plasma may be more promising as quantitative AD markers.
    Role: Principle Investigator
  3. 1R03AG063046-01 (LIU, LEI) Apr 1, 2019 - Jan 31, 2021
    A previously unrecognized ?/?-secretases complex as a therapeutic target for AD
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Liu L, Kwak H, Lawton TL, Jin SX, Meunier AL, Dang Y, Ostaszewski B, Pietras AC, Stern AM, Selkoe DJ. An ultra-sensitive immunoassay detects and quantifies soluble Aß oligomers in human plasma. Alzheimers Dement. 2021 Sep 22. PMID: 34550630.
    Citations:    Fields:    
  2. Lagomarsino VN, Pearse RV, Liu L, Hsieh YC, Fernandez MA, Vinton EA, Paull D, Felsky D, Tasaki S, Gaiteri C, Vardarajan B, Lee H, Muratore CR, Benoit CR, Chou V, Fancher SB, He A, Merchant JP, Duong DM, Martinez H, Zhou M, Bah F, Vicent MA, Stricker JMS, Xu J, Dammer EB, Levey AI, Chibnik LB, Menon V, Seyfried NT, De Jager PL, Noggle S, Selkoe DJ, Bennett DA, Young-Pearse TL. Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors. Neuron. 2021 Aug 26. PMID: 34473944.
    Citations:    Fields:    
  3. Fonseca-Ornelas L, Viennet T, Rovere M, Jiang H, Liu L, Nuber S, Ericsson M, Arthanari H, Selkoe DJ. Altered conformation of a-synuclein drives dysfunction of synaptic vesicles in a synaptosomal model of Parkinson's disease. Cell Rep. 2021 Jul 06; 36(1):109333. PMID: 34233191.
    Citations:    Fields:    
  4. Liu L, Lauro BM, Wolfe MS, Selkoe DJ. Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate ?-secretase function in generating Alzheimer-causing Aß peptides. J Biol Chem. 2021 Jan-Jun; 296:100393. PMID: 33571524.
    Citations:    Fields:    Translation:HumansCells
  5. Nakano M, Mitsuishi Y, Liu L, Watanabe N, Hibino E, Hata S, Saito T, Saido TC, Murayama S, Kasuga K, Ikeuchi T, Suzuki T, Nishimura M. Extracellular Release of ILEI/FAM3C and Amyloid-ß Is Associated with the Activation of Distinct Synapse Subpopulations. J Alzheimers Dis. 2021; 80(1):159-174. PMID: 33492290.
    Citations:    Fields:    Translation:HumansAnimalsCells
  6. Chhatwal JP, Schultz AP, Dang Y, Ostaszewski B, Liu L, Yang HS, Johnson KA, Sperling RA, Selkoe DJ. Plasma N-terminal tau fragment levels predict future cognitive decline and neurodegeneration in healthy elderly individuals. Nat Commun. 2020 11 27; 11(1):6024. PMID: 33247134.
    Citations: 4     Fields:    Translation:Humans
  7. Chao CC, Gutiérrez-Vázquez C, Rothhammer V, Mayo L, Wheeler MA, Tjon EC, Zandee SEJ, Blain M, de Lima KA, Takenaka MC, Avila-Pacheco J, Hewson P, Liu L, Sanmarco LM, Borucki DM, Lipof GZ, Trauger SA, Clish CB, Antel JP, Prat A, Quintana FJ. Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS. Cell. 2019 12 12; 179(7):1483-1498.e22. PMID: 31813625.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  8. Liu L, Lauro BM, Ding L, Rovere M, Wolfe MS, Selkoe DJ. Multiple BACE1 inhibitors abnormally increase the BACE1 protein level in neurons by prolonging its half-life. Alzheimers Dement. 2019 09; 15(9):1183-1194. PMID: 31416794.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  9. Mengel D, Liu L, Yamamoto R, Zülow S, Deuschl C, Hermann DM, Zerr I, Selkoe DJ, Dodel R. A novel V272D presenilin mutation associated with logopenia, disorientation, and apraxia in an autosomal-dominant Alzheimer's disease family. Neurobiol Aging. 2020 01; 85:154.e5-154.e7. PMID: 31500908.
    Citations:    Fields:    Translation:HumansCells
  10. Li S, Liu L, Selkoe D. Verubecestat for Prodromal Alzheimer's Disease. N Engl J Med. 2019 07 25; 381(4):388. PMID: 31340105.
    Citations: 3     Fields:    Translation:Humans
  11. Liu L, Ding L, Rovere M, Wolfe MS, Selkoe DJ. A cellular complex of BACE1 and ?-secretase sequentially generates Aß from its full-length precursor. J Cell Biol. 2019 02 04; 218(2):644-663. PMID: 30626721.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  12. Li S, Jin M, Liu L, Dang Y, Ostaszewski BL, Selkoe DJ. Decoding the synaptic dysfunction of bioactive human AD brain soluble Aß to inspire novel therapeutic avenues for Alzheimer's disease. Acta Neuropathol Commun. 2018 11 08; 6(1):121. PMID: 30409172.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  13. Liu L, Watanabe N, Akatsu H, Nishimura M. Neuronal expression of ILEI/FAM3C and its reduction in Alzheimer's disease. Neuroscience. 2016 08 25; 330:236-46. PMID: 27256505.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  14. Ochiishi T, Itakura A, Liu L, Akatsu H, Kohno H, Nishimura M, Yoshimune K. Immunohistochemical detection of the delayed formation of nonfibrillar large amyloid-ß aggregates. Genes Cells. 2016 Feb; 21(2):200-11. PMID: 26805741.
    Citations:    Fields:    Translation:HumansAnimalsCells
  15. Liu L, Fujino K, Nishimura M. Pre-synaptic localization of the ?-secretase-inhibiting protein p24a2 in the mammalian brain. J Neurochem. 2015 May; 133(3):422-31. PMID: 25438880.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  16. Hasegawa H, Liu L, Tooyama I, Murayama S, Nishimura M. The FAM3 superfamily member ILEI ameliorates Alzheimer's disease-like pathology by destabilizing the penultimate amyloid-ß precursor. Nat Commun. 2014 Jun 04; 5:3917. PMID: 24894631.
    Citations: 8     Fields:    Translation:HumansAnimals
  17. Nishimura M, Nakamura S, Kimura N, Liu L, Suzuki T, Tooyama I. Age-related modulation of ?-secretase activity in non-human primate brains. J Neurochem. 2012 Oct; 123(1):21-8. PMID: 22817324.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  18. Hasegawa H, Liu L, Nishimura M. Dilysine retrieval signal-containing p24 proteins collaborate in inhibiting ?-cleavage of amyloid precursor protein. J Neurochem. 2010 Nov; 115(3):771-81. PMID: 20807314.
    Citations: 4     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.