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Lei Liu, Ph.D., M.D.

Title
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Department
Address
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Biography
education and training
Harbin Medical UniversityMD07/2009Clinical Medicine
Shiga University of Medical SciencePhD10/2014Dementia

Overview

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
Most Recent  |  List All
  1. RF1AG079569 (Jasmeer Chhatwal, Lei Liu, Michael S Wolfe) Aug 12, 2022 - Jul 31, 2027
    NIH
    Leveraging Heterogeneity in Autosomal Dominant AD to Elucidate Pathophysiology and Improve AD Biomarkers
    Role: Principal Investigator
  2. R01AG071865 (CHHATWAL, JASMEER P) Sep 30, 2021 - May 31, 2026
    NIH
    Plasma tau and neurodegenerative markers as predictors of rate of AD progression
    Role: Co-Investigator
  3. PIN Pilot Project (LIU, LEI) Sep 1, 2021 - Aug 31, 2022
    Program for Interdisciplinary Neuroscience/Brigham and Women's Hospital
    Understanding tau protein complexity in Alzheimer’s disease brains
    Role: Principle Investigator
  4. Development Projects (LIU, LEI) Apr 1, 2020 - Mar 31, 2021
    Massachusetts Alzheimer's Disease Research Center
    Understanding tau protein complexity in plasma via novel ultra-sensitive immunoassays
    Role Description: We plan to accurately measure a panel of tau species in plasma, as alterations of tau in plasma may be more promising as quantitative AD markers.
    Role: Principle Investigator
  5. 1R03AG063046-01 (LIU, LEI) Apr 1, 2019 - Jan 31, 2021
    NIH
    A previously unrecognized ?/?-secretases complex as a therapeutic target for AD
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ramalingam N, Jin SX, Moors TE, Fonseca-Ornelas L, Shimanaka K, Lei S, Cam HP, Watson AH, Brontesi L, Ding L, Hacibaloglu DY, Jiang H, Choi SJ, Kanter E, Liu L, Bartels T, Nuber S, Sulzer D, Mosharov EV, Chen WV, Li S, Selkoe DJ, Dettmer U. Dynamic physiological a-synuclein S129 phosphorylation is driven by neuronal activity. NPJ Parkinsons Dis. 2023 Jan 16; 9(1):4. PMID: 36646701; PMCID: PMC9842642.
    Citations:    
  2. Hsieh YC, Negri J, He A, Pearse RV, Liu L, Duong DM, Chibnik LB, Bennett DA, Seyfried NT, Young-Pearse TL. Elevated ganglioside GM2 activator (GM2A) in human brain tissue reduces neurite integrity and spontaneous neuronal activity. Mol Neurodegener. 2022 09 21; 17(1):61. PMID: 36131294; PMCID: PMC9494921.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  3. Stern AM, Liu L, Jin S, Liu W, Meunier AL, Ericsson M, Miller MB, Batson M, Sun T, Kathuria S, Reczek D, Pradier L, Selkoe DJ. A calcium-sensitive antibody isolates soluble amyloid-ß aggregates and fibrils from Alzheimer's disease brain. Brain. 2022 07 29; 145(7):2528-2540. PMID: 35084489; PMCID: PMC9337809.
    Citations: 1     Fields:    Translation:HumansAnimals
  4. Jin SX, Liu L, Li S, Meunier AL, Selkoe DJ. Aß oligomers from human brain impair mossy fiber LTP in CA3 of hippocampus, but activating cAMP-PKA and cGMP-PKG prevents this. Neurobiol Dis. 2022 10 01; 172:105816. PMID: 35820646; PMCID: PMC9809147.
    Citations:    Fields:    Translation:HumansAnimalsCells
  5. Fanning S, Cirka H, Thies JL, Jeong J, Niemi SM, Yoon J, Ho GPH, Pacheco JA, Dettmer U, Liu L, Clish CB, Hodgetts KJ, Hutchinson JN, Muratore CR, Caldwell GA, Caldwell KA, Selkoe D. Lipase regulation of cellular fatty acid homeostasis as a Parkinson's disease therapeutic strategy. NPJ Parkinsons Dis. 2022 Jun 09; 8(1):74. PMID: 35680956; PMCID: PMC9184586.
    Citations:    
  6. Liu L, Cai Y, Lauro BM, Meunier AL, Chhatwal J, Selkoe DJ. Generation and application of semi-synthetic p-Tau181 calibrator for immunoassay calibration. Biochem Biophys Res Commun. 2022 06 30; 611:85-90. PMID: 35483223.
    Citations: 1     Fields:    Translation:HumansCells
  7. Liu L, Lauro BM, He A, Lee H, Bhattarai S, Wolfe MS, Bennett DA, Karch CM, Young-Pearse T, Selkoe DJ. Identification of the Aß37/42 peptide ratio in CSF as an improved Aß biomarker for Alzheimer's disease. Alzheimers Dement. 2023 01; 19(1):79-96. PMID: 35278341; PMCID: PMC9464800.
    Citations: 4     Fields:    Translation:Humans
  8. de Boni L, Watson AH, Zaccagnini L, Wallis A, Zhelcheska K, Kim N, Sanderson J, Jiang H, Martin E, Cantlon A, Rovere M, Liu L, Sylvester M, Lashley T, Dettmer U, Jaunmuktane Z, Bartels T. Brain region-specific susceptibility of Lewy body pathology in synucleinopathies is governed by a-synuclein conformations. Acta Neuropathol. 2022 04; 143(4):453-469. PMID: 35141810; PMCID: PMC8960659.
    Citations: 2     Fields:    Translation:HumansCells
  9. Chhatwal JP, Schultz SA, McDade E, Schultz AP, Liu L, Hanseeuw BJ, Joseph-Mathurin N, Feldman R, Fitzpatrick CD, Sparks KP, Levin J, Berman SB, Renton AE, Esposito BT, Fernandez MV, Sung YJ, Lee JH, Klunk WE, Hofmann A, Noble JM, Graff-Radford N, Mori H, Salloway SM, Masters CL, Martins R, Karch CM, Xiong C, Cruchaga C, Perrin RJ, Gordon BA, Benzinger TLS, Fox NC, Schofield PR, Fagan AM, Goate AM, Morris JC, Bateman RJ, Johnson KA, Sperling RA. Variant-dependent heterogeneity in amyloid ß burden in autosomal dominant Alzheimer's disease: cross-sectional and longitudinal analyses of an observational study. Lancet Neurol. 2022 02; 21(2):140-152. PMID: 35065037; PMCID: PMC8956209.
    Citations: 12     Fields:    Translation:Humans
  10. Tripathi A, Alnakhala H, Terry-Kantor E, Newman A, Liu L, Imberdis T, Fanning S, Nuber S, Ramalingam N, Selkoe D, Dettmer U. Pathogenic Mechanisms of Cytosolic and Membrane-Enriched a-Synuclein Converge on Fatty Acid Homeostasis. J Neurosci. 2022 03 09; 42(10):2116-2130. PMID: 35086904; PMCID: PMC8916762.
    Citations: 1     Fields:    Translation:AnimalsCells
  11. Bhattarai S, Liu L, Wolfe MS. Discovery of aryl aminothiazole ?-secretase modulators with novel effects on amyloid ß-peptide production. Bioorg Med Chem Lett. 2021 12 15; 54:128446. PMID: 34767913; PMCID: PMC9759287.
    Citations: 2     Fields:    Translation:HumansCells
  12. Liu L, Kwak H, Lawton TL, Jin SX, Meunier AL, Dang Y, Ostaszewski B, Pietras AC, Stern AM, Selkoe DJ. An ultra-sensitive immunoassay detects and quantifies soluble Aß oligomers in human plasma. Alzheimers Dement. 2022 06; 18(6):1186-1202. PMID: 34550630; PMCID: PMC8938295.
    Citations: 7     Fields:    Translation:Humans
  13. Lagomarsino VN, Pearse RV, Liu L, Hsieh YC, Fernandez MA, Vinton EA, Paull D, Felsky D, Tasaki S, Gaiteri C, Vardarajan B, Lee H, Muratore CR, Benoit CR, Chou V, Fancher SB, He A, Merchant JP, Duong DM, Martinez H, Zhou M, Bah F, Vicent MA, Stricker JMS, Xu J, Dammer EB, Levey AI, Chibnik LB, Menon V, Seyfried NT, De Jager PL, Noggle S, Selkoe DJ, Bennett DA, Young-Pearse TL. Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors. Neuron. 2021 11 03; 109(21):3402-3420.e9. PMID: 34473944; PMCID: PMC8571042.
    Citations: 19     Fields:    Translation:HumansCells
  14. Fonseca-Ornelas L, Viennet T, Rovere M, Jiang H, Liu L, Nuber S, Ericsson M, Arthanari H, Selkoe DJ. Altered conformation of a-synuclein drives dysfunction of synaptic vesicles in a synaptosomal model of Parkinson's disease. Cell Rep. 2021 07 06; 36(1):109333. PMID: 34233191; PMCID: PMC8552450.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  15. Liu L, Lauro BM, Wolfe MS, Selkoe DJ. Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate ?-secretase function in generating Alzheimer-causing Aß peptides. J Biol Chem. 2021 Jan-Jun; 296:100393. PMID: 33571524.
    Citations: 11     Fields:    Translation:HumansCells
  16. Nakano M, Mitsuishi Y, Liu L, Watanabe N, Hibino E, Hata S, Saito T, Saido TC, Murayama S, Kasuga K, Ikeuchi T, Suzuki T, Nishimura M. Extracellular Release of ILEI/FAM3C and Amyloid-ß Is Associated with the Activation of Distinct Synapse Subpopulations. J Alzheimers Dis. 2021; 80(1):159-174. PMID: 33492290.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  17. Chhatwal JP, Schultz AP, Dang Y, Ostaszewski B, Liu L, Yang HS, Johnson KA, Sperling RA, Selkoe DJ. Plasma N-terminal tau fragment levels predict future cognitive decline and neurodegeneration in healthy elderly individuals. Nat Commun. 2020 11 27; 11(1):6024. PMID: 33247134; PMCID: PMC7695712.
    Citations: 14     Fields:    Translation:Humans
  18. Chao CC, Gutiérrez-Vázquez C, Rothhammer V, Mayo L, Wheeler MA, Tjon EC, Zandee SEJ, Blain M, de Lima KA, Takenaka MC, Avila-Pacheco J, Hewson P, Liu L, Sanmarco LM, Borucki DM, Lipof GZ, Trauger SA, Clish CB, Antel JP, Prat A, Quintana FJ. Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS. Cell. 2019 12 12; 179(7):1483-1498.e22. PMID: 31813625.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  19. Liu L, Lauro BM, Ding L, Rovere M, Wolfe MS, Selkoe DJ. Multiple BACE1 inhibitors abnormally increase the BACE1 protein level in neurons by prolonging its half-life. Alzheimers Dement. 2019 09; 15(9):1183-1194. PMID: 31416794.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  20. Mengel D, Liu L, Yamamoto R, Zülow S, Deuschl C, Hermann DM, Zerr I, Selkoe DJ, Dodel R. A novel V272D presenilin mutation associated with logopenia, disorientation, and apraxia in an autosomal-dominant Alzheimer's disease family. Neurobiol Aging. 2020 01; 85:154.e5-154.e7. PMID: 31500908.
    Citations: 3     Fields:    Translation:HumansCells
  21. Li S, Liu L, Selkoe D. Verubecestat for Prodromal Alzheimer's Disease. N Engl J Med. 2019 07 25; 381(4):388. PMID: 31340105; PMCID: PMC7687351.
    Citations: 5     Fields:    Translation:Humans
  22. Liu L, Ding L, Rovere M, Wolfe MS, Selkoe DJ. A cellular complex of BACE1 and ?-secretase sequentially generates Aß from its full-length precursor. J Cell Biol. 2019 02 04; 218(2):644-663. PMID: 30626721; PMCID: PMC6363461.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  23. Li S, Jin M, Liu L, Dang Y, Ostaszewski BL, Selkoe DJ. Decoding the synaptic dysfunction of bioactive human AD brain soluble Aß to inspire novel therapeutic avenues for Alzheimer's disease. Acta Neuropathol Commun. 2018 11 08; 6(1):121. PMID: 30409172.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  24. Liu L, Watanabe N, Akatsu H, Nishimura M. Neuronal expression of ILEI/FAM3C and its reduction in Alzheimer's disease. Neuroscience. 2016 08 25; 330:236-46. PMID: 27256505.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  25. Ochiishi T, Itakura A, Liu L, Akatsu H, Kohno H, Nishimura M, Yoshimune K. Immunohistochemical detection of the delayed formation of nonfibrillar large amyloid-ß aggregates. Genes Cells. 2016 Feb; 21(2):200-11. PMID: 26805741.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  26. Liu L, Fujino K, Nishimura M. Pre-synaptic localization of the ?-secretase-inhibiting protein p24a2 in the mammalian brain. J Neurochem. 2015 May; 133(3):422-31. PMID: 25438880.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  27. Hasegawa H, Liu L, Tooyama I, Murayama S, Nishimura M. The FAM3 superfamily member ILEI ameliorates Alzheimer's disease-like pathology by destabilizing the penultimate amyloid-ß precursor. Nat Commun. 2014 Jun 04; 5:3917. PMID: 24894631.
    Citations: 13     Fields:    Translation:HumansAnimals
  28. Nishimura M, Nakamura S, Kimura N, Liu L, Suzuki T, Tooyama I. Age-related modulation of ?-secretase activity in non-human primate brains. J Neurochem. 2012 Oct; 123(1):21-8. PMID: 22817324.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  29. Hasegawa H, Liu L, Nishimura M. Dilysine retrieval signal-containing p24 proteins collaborate in inhibiting ?-cleavage of amyloid precursor protein. J Neurochem. 2010 Nov; 115(3):771-81. PMID: 20807314.
    Citations: 7     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.