Harvard Catalyst Profiles

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Lei Liu, Ph.D., M.D.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. 1R03AG063046-01 (LIU, LEI) Apr 1, 2019 - Jan 31, 2021
    A previously unrecognized ?/?-secretases complex as a therapeutic target for AD
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Chao CC, Gutiérrez-Vázquez C, Rothhammer V, Mayo L, Wheeler MA, Tjon EC, Zandee SEJ, Blain M, de Lima KA, Takenaka MC, Avila-Pacheco J, Hewson P, Liu L, Sanmarco LM, Borucki DM, Lipof GZ, Trauger SA, Clish CB, Antel JP, Prat A, Quintana FJ. Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS. Cell. 2019 12 12; 179(7):1483-1498.e22. PMID: 31813625.
  2. Liu L, Lauro BM, Ding L, Rovere M, Wolfe MS, Selkoe DJ. Multiple BACE1 inhibitors abnormally increase the BACE1 protein level in neurons by prolonging its half-life. Alzheimers Dement. 2019 09; 15(9):1183-1194. PMID: 31416794.
  3. Mengel D, Liu L, Yamamoto R, Zülow S, Deuschl C, Hermann DM, Zerr I, Selkoe DJ, Dodel R. A novel V272D presenilin mutation associated with logopenia, disorientation, and apraxia in an autosomal-dominant Alzheimer's disease family. Neurobiol Aging. 2020 01; 85:154.e5-154.e7. PMID: 31500908.
  4. Li S, Liu L, Selkoe D. Verubecestat for Prodromal Alzheimer's Disease. N Engl J Med. 2019 07 25; 381(4):388. PMID: 31340105.
  5. Liu L, Ding L, Rovere M, Wolfe MS, Selkoe DJ. A cellular complex of BACE1 and ?-secretase sequentially generates Aß from its full-length precursor. J Cell Biol. 2019 02 04; 218(2):644-663. PMID: 30626721.
    Citations:    Fields:    
  6. Li S, Jin M, Liu L, Dang Y, Ostaszewski BL, Selkoe DJ. Decoding the synaptic dysfunction of bioactive human AD brain soluble Aß to inspire novel therapeutic avenues for Alzheimer's disease. Acta Neuropathol Commun. 2018 11 08; 6(1):121. PMID: 30409172.
    Citations:    Fields:    
  7. Liu L, Watanabe N, Akatsu H, Nishimura M. Neuronal expression of ILEI/FAM3C and its reduction in Alzheimer's disease. Neuroscience. 2016 08 25; 330:236-46. PMID: 27256505.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  8. Ochiishi T, Itakura A, Liu L, Akatsu H, Kohno H, Nishimura M, Yoshimune K. Immunohistochemical detection of the delayed formation of nonfibrillar large amyloid-ß aggregates. Genes Cells. 2016 Feb; 21(2):200-11. PMID: 26805741.
    Citations:    Fields:    Translation:HumansAnimalsCells
  9. Liu L, Fujino K, Nishimura M. Pre-synaptic localization of the ?-secretase-inhibiting protein p24a2 in the mammalian brain. J Neurochem. 2015 May; 133(3):422-31. PMID: 25438880.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  10. Hasegawa H, Liu L, Tooyama I, Murayama S, Nishimura M. The FAM3 superfamily member ILEI ameliorates Alzheimer's disease-like pathology by destabilizing the penultimate amyloid-ß precursor. Nat Commun. 2014 Jun 04; 5:3917. PMID: 24894631.
    Citations: 3     Fields:    Translation:HumansAnimals
  11. Nishimura M, Nakamura S, Kimura N, Liu L, Suzuki T, Tooyama I. Age-related modulation of ?-secretase activity in non-human primate brains. J Neurochem. 2012 Oct; 123(1):21-8. PMID: 22817324.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  12. Hasegawa H, Liu L, Nishimura M. Dilysine retrieval signal-containing p24 proteins collaborate in inhibiting ?-cleavage of amyloid precursor protein. J Neurochem. 2010 Nov; 115(3):771-81. PMID: 20807314.
    Citations: 4     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.