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Simon Dujardin, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Dujardin S, Fernandes A, Bannon R, Commins C, De Los Santos M, Kamath TV, Hayashi M, Hyman BT. Tau propagation is dependent on the genetic background of mouse strains. Brain Commun. 2022; 4(2):fcac048. PMID: 35350555; PMCID: PMC8952249.
    Citations:    
  2. Petrozziello T, Amaral AC, Dujardin S, Farhan SMK, Chan J, Trombetta BA, Kivisäkk P, Mills AN, Bordt EA, Kim SE, Dooley PM, Commins C, Connors TR, Oakley DH, Ghosal A, Gomez-Isla T, Hyman BT, Arnold SE, Spires-Jones T, Cudkowicz ME, Berry JD, Sadri-Vakili G. Novel genetic variants in MAPT and alterations in tau phosphorylation in amyotrophic lateral sclerosis post-mortem motor cortex and cerebrospinal fluid. Brain Pathol. 2022 03; 32(2):e13035. PMID: 34779076; PMCID: PMC8877756.
    Citations: 1     Fields:    Translation:HumansCells
  3. Petrozziello T, Bordt EA, Mills AN, Kim SE, Sapp E, Devlin BA, Obeng-Marnu AA, Farhan SMK, Amaral AC, Dujardin S, Dooley PM, Henstridge C, Oakley DH, Neueder A, Hyman BT, Spires-Jones TL, Bilbo SD, Vakili K, Cudkowicz ME, Berry JD, DiFiglia M, Silva MC, Haggarty SJ, Sadri-Vakili G. Targeting Tau Mitigates Mitochondrial Fragmentation and Oxidative Stress in Amyotrophic Lateral Sclerosis. Mol Neurobiol. 2022 Jan; 59(1):683-702. PMID: 34757590.
    Citations: 2     Fields:    Translation:HumansCells
  4. Fernandes AR, Dujardin S, Maté de Gérando A, Hyman BT, Frosch MP. Impact of Sterilization Methods on the Seeding Ability of Human Tau Proteopathic Seeds. J Neuropathol Exp Neurol. 2021 10 26; 80(10):912-921. PMID: 34498073.
    Citations:    Fields:    Translation:HumansAnimalsCellsPHPublic Health
  5. Kamath TV, Klickstein N, Commins C, Fernandes AR, Oakley DH, Frosch MP, Hyman BT, Dujardin S. Kinetics of tau aggregation reveals patient-specific tau characteristics among Alzheimer's cases. Brain Commun. 2021; 3(2):fcab096. PMID: 34222869.
    Citations:    
  6. Cooper JM, Lathuiliere A, Migliorini M, Arai AL, Wani MM, Dujardin S, Muratoglu SC, Hyman BT, Strickland DK. Regulation of tau internalization, degradation, and seeding by LRP1 reveals multiple pathways for tau catabolism. J Biol Chem. 2021 Jan-Jun; 296:100715. PMID: 33930462.
    Citations: 2     Fields:    Translation:HumansCells
  7. Oakley DH, Klickstein N, Commins C, Chung M, Dujardin S, Bennett RE, Hyman BT, Frosch MP. Continuous Monitoring of Tau-Induced Neurotoxicity in Patient-Derived iPSC-Neurons. J Neurosci. 2021 05 12; 41(19):4335-4348. PMID: 33893219.
    Citations:    Fields:    Translation:HumansAnimalsCells
  8. Dujardin S, Commins C, Lathuiliere A, Beerepoot P, Fernandes AR, Kamath TV, De Los Santos MB, Klickstein N, Corjuc DL, Corjuc BT, Dooley PM, Viode A, Oakley DH, Moore BD, Mullin K, Jean-Gilles D, Clark R, Atchison K, Moore R, Chibnik LB, Tanzi RE, Frosch MP, Serrano-Pozo A, Elwood F, Steen JA, Kennedy ME, Hyman BT. Author Correction: Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease. Nat Med. 2021 Feb; 27(2):356. PMID: 33514949; PMCID: PMC8363121.
    Citations: 1     Fields:    
  9. Sepulveda-Falla D, Chavez-Gutierrez L, Portelius E, Vélez JI, Dujardin S, Barrera-Ocampo A, Dinkel F, Hagel C, Puig B, Mastronardi C, Lopera F, Hyman BT, Blennow K, Arcos-Burgos M, de Strooper B, Glatzel M. A multifactorial model of pathology for age of onset heterogeneity in familial Alzheimer's disease. Acta Neuropathol. 2021 02; 141(2):217-233. PMID: 33319314.
    Citations: 10     Fields:    Translation:HumansCells
  10. Wesseling H, Mair W, Kumar M, Schlaffner CN, Tang S, Beerepoot P, Fatou B, Guise AJ, Cheng L, Takeda S, Muntel J, Rotunno MS, Dujardin S, Davies P, Kosik KS, Miller BL, Berretta S, Hedreen JC, Grinberg LT, Seeley WW, Hyman BT, Steen H, Steen JA. Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer's Disease. Cell. 2020 12 10; 183(6):1699-1713.e13. PMID: 33188775.
    Citations: 84     Fields:    Translation:HumansCells
  11. Perez-Rando M, Dujardin S, Bennett RE, Commins C, Nibhanupudy T, Hyman BT. Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seeds. Acta Neuropathol Commun. 2020 10 19; 8(1):168. PMID: 33076986.
    Citations:    Fields:    Translation:HumansAnimalsCells
  12. Bennett RE, Hu M, Fernandes A, Perez-Rando M, Robbins A, Kamath T, Dujardin S, Hyman BT. Tau reduction in aged mice does not impact Microangiopathy. Acta Neuropathol Commun. 2020 08 18; 8(1):137. PMID: 32811565.
    Citations:    Fields:    Translation:HumansAnimals
  13. Dujardin S, Commins C, Lathuiliere A, Beerepoot P, Fernandes AR, Kamath TV, De Los Santos MB, Klickstein N, Corjuc DL, Corjuc BT, Dooley PM, Viode A, Oakley DH, Moore BD, Mullin K, Jean-Gilles D, Clark R, Atchison K, Moore R, Chibnik LB, Tanzi RE, Frosch MP, Serrano-Pozo A, Elwood F, Steen JA, Kennedy ME, Hyman BT. Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease. Nat Med. 2020 08; 26(8):1256-1263. PMID: 32572268; PMCID: PMC7603860.
    Citations: 96     Fields:    Translation:HumansCells
  14. Calvo-Rodriguez M, Hou SS, Snyder AC, Dujardin S, Shirani H, Nilsson KPR, Bacskai BJ. In vivo detection of tau fibrils and amyloid ß aggregates with luminescent conjugated oligothiophenes and multiphoton microscopy. Acta Neuropathol Commun. 2019 11 08; 7(1):171. PMID: 31703739.
    Citations: 16     Fields:    Translation:AnimalsCells
  15. Colin M, Dujardin S, Schraen-Maschke S, Meno-Tetang G, Duyckaerts C, Courade JP, Buée L. From the prion-like propagation hypothesis to therapeutic strategies of anti-tau immunotherapy. Acta Neuropathol. 2020 01; 139(1):3-25. PMID: 31686182.
    Citations: 45     Fields:    Translation:HumansAnimals
  16. Hanlon KS, Meltzer JC, Buzhdygan T, Cheng MJ, Sena-Esteves M, Bennett RE, Sullivan TP, Razmpour R, Gong Y, Ng C, Nammour J, Maiz D, Dujardin S, Ramirez SH, Hudry E, Maguire CA. Selection of an Efficient AAV Vector for Robust CNS Transgene Expression. Mol Ther Methods Clin Dev. 2019 Dec 13; 15:320-332. PMID: 31788496; PMCID: PMC6881693.
    Citations: 31     
  17. Eftekharzadeh B, Daigle JG, Kapinos LE, Coyne A, Schiantarelli J, Carlomagno Y, Cook C, Miller SJ, Dujardin S, Amaral AS, Grima JC, Bennett RE, Tepper K, DeTure M, Vanderburg CR, Corjuc BT, DeVos SL, Gonzalez JA, Chew J, Vidensky S, Gage FH, Mertens J, Troncoso J, Mandelkow E, Salvatella X, Lim RYH, Petrucelli L, Wegmann S, Rothstein JD, Hyman BT. Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease. Neuron. 2019 Jan 16; 101(2):349. PMID: 30653936; PMCID: PMC6377243.
    Citations: 4     Fields:    
  18. Dujardin S, Hyman BT. Tau Prion-Like Propagation: State of the Art and Current Challenges. Adv Exp Med Biol. 2019; 1184:305-325. PMID: 32096046.
    Citations: 17     Fields:    Translation:Humans
  19. Busche MA, Wegmann S, Dujardin S, Commins C, Schiantarelli J, Klickstein N, Kamath TV, Carlson GA, Nelken I, Hyman BT. Tau impairs neural circuits, dominating amyloid-ß effects, in Alzheimer models in vivo. Nat Neurosci. 2019 01; 22(1):57-64. PMID: 30559471; PMCID: PMC6560629.
    Citations: 95     Fields:    Translation:AnimalsCells
  20. Dujardin S, Bégard S, Caillierez R, Lachaud C, Carrier S, Lieger S, Gonzalez JA, Deramecourt V, Déglon N, Maurage CA, Frosch MP, Hyman BT, Colin M, Buée L. Different tau species lead to heterogeneous tau pathology propagation and misfolding. Acta Neuropathol Commun. 2018 11 29; 6(1):132. PMID: 30497516.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  21. Eftekharzadeh B, Daigle JG, Kapinos LE, Coyne A, Schiantarelli J, Carlomagno Y, Cook C, Miller SJ, Dujardin S, Amaral AS, Grima JC, Bennett RE, Tepper K, DeTure M, Vanderburg CR, Corjuc BT, DeVos SL, Gonzalez JA, Chew J, Vidensky S, Gage FH, Mertens J, Troncoso J, Mandelkow E, Salvatella X, Lim RYH, Petrucelli L, Wegmann S, Rothstein JD, Hyman BT. Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease. Neuron. 2018 09 05; 99(5):925-940.e7. PMID: 30189209.
    Citations: 120     Fields:    Translation:HumansAnimalsCells
  22. DeVos SL, Corjuc BT, Commins C, Dujardin S, Bannon RN, Corjuc D, Moore BD, Bennett RE, Jorfi M, Gonzales JA, Dooley PM, Roe AD, Pitstick R, Irimia D, Frosch MP, Carlson GA, Hyman BT. Tau reduction in the presence of amyloid-ß prevents tau pathology and neuronal death in vivo. Brain. 2018 07 01; 141(7):2194-2212. PMID: 29733334; PMCID: PMC6022692.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  23. Wegmann S, Eftekharzadeh B, Tepper K, Zoltowska KM, Bennett RE, Dujardin S, Laskowski PR, MacKenzie D, Kamath T, Commins C, Vanderburg C, Roe AD, Fan Z, Molliex AM, Hernandez-Vega A, Muller D, Hyman AA, Mandelkow E, Taylor JP, Hyman BT. Tau protein liquid-liquid phase separation can initiate tau aggregation. EMBO J. 2018 04 03; 37(7). PMID: 29472250.
    Citations: 235     Fields:    Translation:HumansAnimalsCells
  24. Mudher A, Colin M, Dujardin S, Medina M, Dewachter I, Alavi Naini SM, Mandelkow EM, Mandelkow E, Buée L, Goedert M, Brion JP. What is the evidence that tau pathology spreads through prion-like propagation? Acta Neuropathol Commun. 2017 Dec 19; 5(1):99. PMID: 29258615; PMCID: PMC5735872.
    Citations: 113     Fields:    Translation:Humans
  25. Bennett RE, DeVos SL, Dujardin S, Corjuc B, Gor R, Gonzalez J, Roe AD, Frosch MP, Pitstick R, Carlson GA, Hyman BT. Enhanced Tau Aggregation in the Presence of Amyloid ß. Am J Pathol. 2017 Jul; 187(7):1601-1612. PMID: 28500862; PMCID: PMC5500829.
    Citations: 75     Fields:    Translation:HumansAnimalsCells
  26. Tardivel M, Bégard S, Bousset L, Dujardin S, Coens A, Melki R, Buée L, Colin M. Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies. Acta Neuropathol Commun. 2016 11 04; 4(1):117. PMID: 27809932.
    Citations: 103     Fields:    Translation:HumansAnimalsCells
  27. Dujardin S, Colin M, Buée L. Invited review: Animal models of tauopathies and their implications for research/translation into the clinic. Neuropathol Appl Neurobiol. 2015 Feb; 41(1):59-80. PMID: 25428793.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  28. Dujardin S, Bégard S, Caillierez R, Lachaud C, Delattre L, Carrier S, Loyens A, Galas MC, Bousset L, Melki R, Aurégan G, Hantraye P, Brouillet E, Buée L, Colin M. Ectosomes: a new mechanism for non-exosomal secretion of tau protein. PLoS One. 2014; 9(6):e100760. PMID: 24971751.
    Citations: 94     Fields:    Translation:HumansAnimalsCells
  29. Dujardin S, Lécolle K, Caillierez R, Bégard S, Zommer N, Lachaud C, Carrier S, Dufour N, Aurégan G, Winderickx J, Hantraye P, Déglon N, Colin M, Buée L. Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies. Acta Neuropathol Commun. 2014 Jan 30; 2:14. PMID: 24479894.
    Citations: 102     Fields:    Translation:HumansAnimalsCells
  30. Caillierez R, Bégard S, Lécolle K, Deramecourt V, Zommer N, Dujardin S, Loyens A, Dufour N, Aurégan G, Winderickx J, Hantraye P, Déglon N, Buée L, Colin M. Lentiviral delivery of the human wild-type tau protein mediates a slow and progressive neurodegenerative tau pathology in the rat brain. Mol Ther. 2013 Jul; 21(7):1358-68. PMID: 23609018.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  31. Deramecourt V, Lebert F, Maurage CA, Fernandez-Gomez FJ, Dujardin S, Colin M, Sergeant N, Buée-Scherrer V, Clot F, Ber IL, Brice A, Pasquier F, Buée L. Clinical, neuropathological, and biochemical characterization of the novel tau mutation P332S. J Alzheimers Dis. 2012; 31(4):741-9. PMID: 22699846.
    Citations: 14     Fields:    Translation:HumansCells
  32. Makishima H, Jankowska AM, McDevitt MA, O'Keefe C, Dujardin S, Cazzolli H, Przychodzen B, Prince C, Nicoll J, Siddaiah H, Shaik M, Szpurka H, Hsi E, Advani A, Paquette R, Maciejewski JP. CBL, CBLB, TET2, ASXL1, and IDH1/2 mutations and additional chromosomal aberrations constitute molecular events in chronic myelogenous leukemia. Blood. 2011 May 26; 117(21):e198-206. PMID: 21346257; PMCID: PMC3110035.
    Citations: 77     Fields:    Translation:Humans
  33. Libersa P, Dujardin S, Francke JP, Libersa JC, Pertuzon B. [A technic using MRI. A comparative study of 3 anesthetic technics of the inferior alveolar nerve]. Bull Group Int Rech Sci Stomatol Odontol. 1999 Oct-Dec; 41(4):97-103. PMID: 11799743; PMCID: PMC2730260.
    Citations:    Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.