Harvard Catalyst Profiles

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Peng Li, Ph.D.

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Biography
2016
2016 Partners Healthcare Innovation Discovery, Partners Healthcare (not Mass General Brigham)
2018
Trainee Professional Development Award, Society for Neuroscience
2019
Brigham Research Institute Microgrant Award, Brigham and Women's Hospital
2020
1st place of Club Hypnos Cup Data Blitz competition (virtual due to COVID19), Sleep Research Society
2020
Travel Award, the International Workshop on HIV & Aging (converted to fee waiver due to COVID 19)
2021
Young Investigators Research Forum Award, American Academy of Sleep Medicine

Overview
I am an Assistant Professor of Medicine at the HMS and an associate physiologist at the Division of Sleep and Circadian Disorders (DSCD), BWH. I also serve as the Research Director of the Medical Biodynamics Program, a cross-disciplinary research and training program whose major goal is to promote translational research in sleep medicine and facilitate interdisciplinary collaborations.

Research Interests:
I am interested in understanding sleep/circadian disturbances as potential risk factors of neurodegeneration or cognitive complications. As a trained biomedical engineer during my Ph.D., I am also interested in designing new tools through biomedical signal analyses to predict disease progression and monitor health status. I have developed and applied many nonlinear algorithms for harnessing changes in physiological signals that are better connected to adverse outcomes than traditional analytical approaches. My current research activities include examining the relationships of circadian function and autonomic function with cognitive impairment and Alzheimer’s disease or dementia, and the role of sleep/circadian control in cognitive function/resilience in more vulnerable populations such as people living with HIV infection.

Society Memberships:
American Academy of Sleep Medicine
American Heart Association
IEEE Engineering in Medicine and Biology Society
Sleep Research Society
Society for Neuroscience
The Alzheimer's Association International Society to Advance Alzheimer Research and Treatment (ISTAART)

Mentors:
Kun Hu, Ph.D., 2016-present (Primary)
Monty A. Montano, Ph.D., 2020-present (Co-mentor on HIV and Aging)
Ingrid T. Katz, MD, 2020-present (Co-mentor on clinical management of PLWH)

Trainees:

Postdoctoral Fellows
Chenlu Gao, Ph.D., 2021-present

Research Assistants (*indicates a trainee for whom I was/am a co-mentor)
*Chelsea Hu, B.S., 2017-2019
*Longchang Cui, B.S., 2019-2020
*Arlen Gaba, B.S., 2019-present
*Ma Cherrysse Ulsa, B.S., 2020-present
Xi Zheng, M.S., 2020-present

Visiting Ph.D. students
Ruixue Cai, M.S., 2022-present

Undergraduates (*indicates a trainee for whom I was/am a co-mentor)
*Nicole Nikolaeva Gaykova, 2021-present

High school students
Max Wagner, 2021-present

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. AARFD-22-928372 (GAO, CHENLU) Mar 1, 2022 - Feb 28, 2025
    Alzheimer's Association
    Timing and irregularity of daytime napping and Alzheimer’s disease
    Role: Primary Mentor
  2. UWSC12802 (LI, PENG) May 1, 2021 - Apr 30, 2022
    NIH/NIA
    Association between rest activity circadian rhythm and cognition in PLWH
    Role: Principal Investigator
  3. CFAR-BWH-21-1-LI (LI, PENG) Feb 1, 2021 - May 31, 2022
    Harvard University Center for AIDS Research
    Circadian disturbances and cognitive impairment in people living with HIV
    Role: Principal Investigator
  4. A2020886S (LI, PENG) Sep 1, 2020 - Aug 31, 2023
    The BrightFocus Foundation
    Circadian regulation, autonomic function, and Alzheimer’s disease
    Role: Principal Investigator

Featured Content

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Li P, Gao L, Yu L, Zheng X, Ulsa MC, Yang HW, Gaba A, Yaffe K, Bennett DA, Buchman AS, Hu K, Leng Y. Daytime napping and Alzheimer's dementia: A potential bidirectional relationship. Alzheimers Dement. 2022 Mar 17. PMID: 35297533.
    Citations:    
  2. Qian J, Morris CJ, Phillips AJK, Li P, Rahman SA, Wang W, Hu K, Arendt J, Czeisler CA, Scheer FAJL. Unanticipated daytime melatonin secretion on a simulated night shift schedule generates a distinctive 24-h melatonin rhythm with antiphasic daytime and nighttime peaks. J Pineal Res. 2022 Apr; 72(3):e12791. PMID: 35133678.
    Citations:    Fields:    
  3. Ulsa MC, Xi Z, Li P, Gaba A, Wong PM, Saxena R, Scheer FAJL, Rutter M, Akeju O, Hu K, Gao L. Association of Poor Sleep Burden in Middle Age and Older Adults With Risk for Delirium During Hospitalization. J Gerontol A Biol Sci Med Sci. 2022 Mar 03; 77(3):507-516. PMID: 34558609.
    Citations: 1     Fields:    
  4. Li P, Gao L, Gao C, Parker RA, Katz IT, Montano MA, Hu K. Daytime Sleep Behaviors and Cognitive Performance in Middle- to Older-Aged Adults Living with and without HIV Infection. Nat Sci Sleep. 2022; 14:181-191. PMID: 35173500.
    Citations:    
  5. Farina A, Mullet TC, Bazarbayeva TA, Tazhibayeva T, Bulatova D, Li P. Perspectives on the Ecological Role of Geophysical Sounds. Frontiers in Ecology and Evolution. 2021; 9:919. View Publication.
  6. Gao L, Gaba A, Li P, Saxena R, Scheer FAJL, Akeju O, Rutter MK, Hu K. Heart rate response and recovery during exercise predict future delirium risk-A prospective cohort study in middle- to older-aged adults. J Sport Health Sci. 2021 Dec 13. PMID: 34915199.
    Citations:    Fields:    
  7. Li P, Zheng X, Ulsa MC, Yang HW, Scheer FAJL, Rutter MK, Hu K, Gao L. Poor sleep behavior burden and risk of COVID-19 mortality and hospitalization. Sleep. 2021 08 13; 44(8). PMID: 34142713.
    Citations: 3     Fields:    Translation:HumansCells
  8. Wang L, Wang J, Li P, Wang X, Wu S, Shi B. Association between short-term heart rate variability and blood coagulation in patients with breast cancer. Sci Rep. 2021 07 29; 11(1):15414. PMID: 34326419.
    Citations:    Fields:    Translation:Humans
  9. Yang HW, Garaulet M, Li P, Bandin C, Lin C, Lo MT, Hu K. Daily Rhythm of Fractal Cardiac Dynamics Links to Weight Loss Resistance: Interaction with CLOCK 3111T/C Genetic Variant. Nutrients. 2021 Jul 19; 13(7). PMID: 34371977.
    Citations:    
  10. Gao L, Li P, Gaba A, Musiek E, Ju YS, Hu K. Fractal motor activity regulation and sex differences in preclinical Alzheimer's disease pathology. Alzheimers Dement (Amst). 2021; 13(1):e12211. PMID: 34189248.
    Citations: 1     
  11. Li P, Gaba A, Wong PM, Cui L, Yu L, Bennett DA, Buchman AS, Gao L, Hu K. Objective Assessment of Daytime Napping and Incident Heart Failure in 1140 Community-Dwelling Older Adults: A Prospective, Observational Cohort Study. J Am Heart Assoc. 2021 06 15; 10(12):e019037. PMID: 34075783.
    Citations: 1     Fields:    Translation:Humans
  12. Zhao L, Li P, Li J, Liu C. Influence of Ectopic Beats on Heart Rate Variability Analysis. Entropy (Basel). 2021 May 22; 23(6). PMID: 34067255.
    Citations:    
  13. Liu T, Li P, Liu Y, Zhang H, Li Y, Jiao Y, Liu C, Karmakar C, Liang X, Ren M, Wang X. Detection of Coronary Artery Disease Using Multi-Domain Feature Fusion of Multi-Channel Heart Sound Signals. Entropy (Basel). 2021 May 21; 23(6). PMID: 34064025.
    Citations:    
  14. Yan C, Liu C, Yao L, Wang X, Wang J, Li P. Short-Term Effect of Percutaneous Coronary Intervention on Heart Rate Variability in Patients with Coronary Artery Disease. Entropy (Basel). 2021 Apr 28; 23(5). PMID: 33924819.
    Citations: 1     
  15. Hu K, Li P, Gao L. Sleep, rest-activity rhythms and aging: a complex web in Alzheimer's disease? Neurobiol Aging. 2021 08; 104:102-103. PMID: 33902941.
    Citations: 3     Fields:    Translation:Humans
  16. Farina A, Eldridge A, Li P. Ecoacoustics and multispecies semiosis: Naming, semantics, semiotic characteristics, and competencies. Biosemiotics. 2021; 14(1):141-165. View Publication.
  17. Gao L, Gaba A, Cui L, Yang HW, Saxena R, Scheer FAJL, Akeju O, Rutter MK, Lo MT, Hu K, Li P. Resting Heartbeat Complexity Predicts All-Cause and Cardiorespiratory Mortality in Middle- to Older-Aged Adults From the UK Biobank. J Am Heart Assoc. 2021 02 02; 10(3):e018483. PMID: 33461311.
    Citations: 2     Fields:    Translation:Humans
  18. Farina A, Righini R, Fuller S, Li P, Pavan G. Acoustic complexity indices reveal the acoustic communities of the old-growth Mediterranean forest of Sasso Fratino Integral Natural Reserve (Central Italy). Ecological Indicators. 2021; 120:106927. View Publication.
  19. Shi B, Motin MA, Wang X, Karmakar C, Li P. Bivariate Entropy Analysis of Electrocardiographic RR-QT Time Series. Entropy (Basel). 2020 Dec 20; 22(12). PMID: 33419293.
    Citations: 2     
  20. Zhang H, Wang X, Liu C, Liu Y, Li P, Yao L, Li H, Wang J, Jiao Y. Detection of coronary artery disease using multi-modal feature fusion and hybrid feature selection. Physiol Meas. 2020 12 09; 41(11). PMID: 33080588.
    Citations: 1     Fields:    Translation:Humans
  21. Li P, Gao L, Gaba A, Yu L, Cui L, Fan W, Lim ASP, Bennett DA, Buchman AS, Hu K. Circadian disturbances in Alzheimer's disease progression: a prospective observational cohort study of community-based older adults. Lancet Healthy Longev. 2020 Dec; 1(3):e96-e105. PMID: 34179863.
    Citations: 9     
  22. Udhayakumar R, Karmakar C, Li P, Wang X, Palaniswami M. Modified Distribution Entropy as a Complexity Measure of Heart Rate Variability (HRV) Signal. Entropy (Basel). 2020 Sep 24; 22(10). PMID: 33286846.
    Citations: 1     
  23. Yao L, Liu C, Li P, Wang J, Liu Y, Li W, Wang X, Li H, Zhang H. Enhanced Automated Diagnosis of Coronary Artery Disease Using Features Extracted From QT Interval Time Series and ST–T Waveform. IEEE Access. 2020; 8:129510-129524. View Publication.
  24. Gao L, Lim ASP, Wong PM, Gaba A, Cui L, Yu L, Buchman AS, Bennett DA, Hu K, Li P. Fragmentation of Rest/Activity Patterns in Community-Based Elderly Individuals Predicts Incident Heart Failure. Nat Sci Sleep. 2020; 12:299-307. PMID: 32581616.
    Citations: 5     
  25. Knapen SE, Li P, Riemersma-van der Lek RF, Verkooijen S, Boks MPM, Schoevers RA, Scheer FAJL, Hu K. Fractal biomarker of activity in patients with bipolar disorder. Psychol Med. 2021 07; 51(9):1562-1569. PMID: 32234100.
    Citations: 3     Fields:    Translation:Humans
  26. Wang L, Shi B, Li P, Zhang G, Liu M, Chen D. Short-term heart rate variability and blood biomarkers of gastric cancer prognosis. IEEE Access. 2020; 8:15159-15165. View Publication.
  27. Gao L, Smielewski P, Li P, Czosnyka M, Ercole A. Signal Information Prediction of Mortality Identifies Unique Patient Subsets after Severe Traumatic Brain Injury: A Decision-Tree Analysis Approach. J Neurotrauma. 2020 04 01; 37(7):1011-1019. PMID: 31744382.
    Citations: 5     Fields:    Translation:Humans
  28. Li P, Lim ASP, Gao L, Hu C, Yu L, Bennett DA, Buchman AS, Hu K. More random motor activity fluctuations predict incident frailty, disability, and mortality. Sci Transl Med. 2019 10 30; 11(516). PMID: 31666398.
    Citations: 11     Fields:    Translation:Humans
  29. Shi B, Wang L, Yan C, Chen D, Liu M, Li P. Nonlinear heart rate variability biomarkers for gastric cancer severity: A pilot study. Sci Rep. 2019 09 25; 9(1):13833. PMID: 31554856.
    Citations: 10     Fields:    Translation:Humans
  30. Li H, Wang X, Liu C, Wang Y, Li P, Tang H, Yao L, Zhang H. Dual-input neural network integrating feature extraction and deep learning for coronary artery disease detection using electrocardiogram and phonocardiogram. IEEE Access. 2019; 7:146457-146469. View Publication.
  31. Li P, Yu L, Yang J, Lo MT, Hu C, Buchman AS, Bennett DA, Hu K. Interaction between the progression of Alzheimer's disease and fractal degradation. Neurobiol Aging. 2019 11; 83:21-30. PMID: 31585364.
    Citations: 7     Fields:    Translation:Humans
  32. Yao L, Li P, Liu C, Hou Y, Yan C, Li L, Li K, Wang X, Deogire A, Du C, Zhang H, Wang J, Li H. Comparison of QT interval variability of coronary patients without myocardial infarction with that of patients with old myocardial infarction. Comput Biol Med. 2019 10; 113:103396. PMID: 31446319.
    Citations: 3     Fields:    Translation:HumansCTClinical Trials
  33. Azami H, Li P, Arnold SE, Escudero J, Humeau-Heurtier A. Fuzzy entropy metrics for the analysis of biomedical signals: assessment and comparison. IEEE Access. 2019; 7:104833-104847. View Publication.
  34. Gao L, Li P, Hu C, To T, Patxot M, Falvey B, Wong PM, Scheer FAJL, Lin C, Lo MT, Hu K. Nocturnal heart rate variability moderates the association between sleep-wake regularity and mood in young adults. Sleep. 2019 05 01; 42(5). PMID: 30722058.
    Citations: 5     Fields:    Translation:Humans
  35. Yan C, Li P, Liu C, Wang X, Yin C, Yao L. Novel gridded descriptors of poincaré plot for analyzing heartbeat interval time-series. Comput Biol Med. 2019 06; 109:280-289. PMID: 31100581.
    Citations: 4     Fields:    Translation:Humans
  36. Li Y, Wang X, Liu C, Li L, Yan C, Yao L, Li P. Variability of cardiac electromechanical delay with application to the noninvasive detection of coronary artery disease. IEEE Access. 2019; 7:53115-53124. View Publication.
  37. Li P. EZ Entropy: a software application for the entropy analysis of physiological time-series. Biomed Eng Online. 2019 Mar 20; 18(1):30. PMID: 30894180.
    Citations: 8     Fields:    
  38. Yan C, Li P, Yao L, Karmakar C, Liu C. Impacts of reference points and reference lines on the slope- and area-based heart rate asymmetry analysis. Measurement. 2019; 137:515-526. View Publication.
  39. Wu JQ, Li P, Stavitsky Gilbert K, Hu K, Cronin-Golomb A. Circadian Rest-Activity Rhythms Predict Cognitive Function in Early Parkinson's Disease Independently of Sleep. Mov Disord Clin Pract. 2018 Nov-Dec; 5(6):614-619. PMID: 30637282.
    Citations: 12     
  40. Jiang X, Wei S, Ji J, Liu F, Li P, Liu C. Modeling radial artery pressure waveforms using curve fitting: comparison of four types of fitting functions. Artery Res. 2018; 23(C):56-62. View Publication.
  41. Li Y, Li P, Wang X, Karmakar C, Liu C, Liu C. Short-term QT interval variability in patients with coronary artery disease and congestive heart failure: a comparison with healthy control subjects. Med Biol Eng Comput. 2019 Feb; 57(2):389-400. PMID: 30143993.
    Citations: 3     Fields:    Translation:Humans
  42. Zheng D, Chen F, Li P, Peng SY. Advanced Signal Processing for Cardiovascular and Neurological Diseases. Comput Math Methods Med. 2018; 2018:3416540. PMID: 30073030.
    Citations:    Fields:    Translation:Humans
  43. Li P, Yu L, Lim ASP, Buchman AS, Scheer FAJL, Shea SA, Schneider JA, Bennett DA, Hu K. Fractal regulation and incident Alzheimer's disease in elderly individuals. Alzheimers Dement. 2018 09; 14(9):1114-1125. PMID: 29733807.
    Citations: 13     Fields:    Translation:Humans
  44. Wang X, Yan C, Shi B, Liu C, Karmakar C, Li P. Does the Temporal Asymmetry of Short-Term Heart Rate Variability Change during Regular Walking? A Pilot Study of Healthy Young Subjects. Comput Math Methods Med. 2018; 2018:3543048. PMID: 29853984.
    Citations: 3     Fields:    Translation:Humans
  45. Li P, Karmakar C, Yearwood J, Venkatesh S, Palaniswami M, Liu C. Detection of epileptic seizure based on entropy analysis of short-term EEG. PLoS One. 2018; 13(3):e0193691. PMID: 29543825.
    Citations: 11     Fields:    Translation:Humans
  46. Ji L, Liu C, Li P, Wang X, Liu C, Hou Y. Increased pulse wave transit time after percutaneous coronary intervention procedure in CAD patients. Sci Rep. 2018 01 08; 8(1):115. PMID: 29311630.
    Citations: 3     Fields:    Translation:Humans
  47. Shi B, Zhang Y, Yuan C, Wang S, Li P. Entropy analysis of short-term heartbeat interval time series during regular walking. Entropy. 2017; 19(10):568. View Publication.
  48. Yan C, Li P, Ji L, Yao L, Karmakar C, Liu C. Area asymmetry of heart rate variability signal. Biomed Eng Online. 2017 Sep 21; 16(1):112. PMID: 28934961.
    Citations: 7     Fields:    Translation:Humans
  49. Karmakar C, Udhayakumar RK, Li P, Venkatesh S, Palaniswami M. Stability, Consistency and Performance of Distribution Entropy in Analysing Short Length Heart Rate Variability (HRV) Signal. Front Physiol. 2017; 8:720. PMID: 28979215.
    Citations: 9     
  50. Li P, Morris CJ, Patxot M, Yugay T, Mistretta J, Purvis TE, Scheer FAJL, Hu K. Reduced Tolerance to Night Shift in Chronic Shift Workers: Insight From Fractal Regulation. Sleep. 2017 07 01; 40(7). PMID: 28838129.
    Citations: 12     Fields:    Translation:Humans
  51. Wang S, Li P, Chen P, Phillips P, Liu G, Du S, Zhang Y. Pathological brain detection via wavelet packet tsallis entropy and real-coded biogeography-based optimization. Fundam Inform. 2017; 151(1-4):275-291. View Publication.
  52. Li P, To T, Chiang WY, Escobar C, Buijs RM, Hu K. Fractal Regulation in Temporal Activity Fluctuations: A Biomarker for Circadian Control and Beyond. JSM Biomark. 2017; 3(1). PMID: 28553673.
    Citations: 4     
  53. Hu K, Riemersma-van der Lek RF, Patxot M, Li P, Shea SA, Scheer FA, Van Someren EJ. Progression of Dementia Assessed by Temporal Correlations of Physical Activity: Results From a 3.5-Year, Longitudinal Randomized Controlled Trial. Sci Rep. 2016 06 13; 6:27742. PMID: 27292543.
    Citations: 15     Fields:    Translation:Humans
  54. Ji L, Li P, Liu C, Wang X, Yang J, Liu C. Measuring electromechanical coupling in patients with coronary artery disease and healthy subjects. Entropy. 2016; 18(4):153. View Publication.
  55. Li P, Karmakar C, Yan C, Palaniswami M, Liu C. Classification of 5-S Epileptic EEG Recordings Using Distribution Entropy and Sample Entropy. Front Physiol. 2016; 7:136. PMID: 27148074.
    Citations: 15     
  56. Li P, Li K, Liu C, Zheng D, Li ZM, Liu C. Detection of Coupling in Short Physiological Series by a Joint Distribution Entropy Method. IEEE Trans Biomed Eng. 2016 11; 63(11):2231-2242. PMID: 26760967.
    Citations: 10     Fields:    Translation:HumansAnimals
  57. Ji L, Liu C, Li P, Wang X, Yan C, Liu C. Comparison of heart rate variability between resting state and external-cuff-inflation-and-deflation state: a pilot study. Physiol Meas. 2015 Oct; 36(10):2135-46. PMID: 26333766.
    Citations:    Fields:    Translation:Humans
  58. Ji L, Li P, Li K, Wang X, Liu C. Analysis of short-term heart rate and diastolic period variability using a refined fuzzy entropy method. Biomed Eng Online. 2015 Jul 01; 14:64. PMID: 26126807.
    Citations: 8     Fields:    Translation:HumansCTClinical Trials
  59. Li P, Yan C, Karmakar C, Liu C. Distribution entropy analysis of epileptic EEG signals. Annu Int Conf IEEE Eng Med Biol Soc. 2015; 2015:4170-3. PMID: 26737213.
    Citations: 6     Fields:    Translation:Humans
  60. Li P, Liu C, Li K, Zheng D, Liu C, Hou Y. Assessing the complexity of short-term heartbeat interval series by distribution entropy. Med Biol Eng Comput. 2015 Jan; 53(1):77-87. PMID: 25351477.
    Citations: 43     Fields:    Translation:Humans
  61. Liu C, Li P, Di Maria C, Zhao L, Zhang H, Chen Z. A multi-step method with signal quality assessment and fine-tuning procedure to locate maternal and fetal QRS complexes from abdominal ECG recordings. Physiol Meas. 2014 Aug; 35(8):1665-83. PMID: 25069817.
    Citations: 8     Fields:    Translation:Humans
  62. Sun X, Li K, Ren H, Li P, Wang X, Liu C. Influence of timing algorithm on brachialankle pulse wave velocity measurement. Biomed Mater Eng. 2014; 24(1):255-61. PMID: 24211905.
    Citations:    Fields:    Translation:Humans
  63. Li P, Liu C, Wang X, Zheng D, Li Y, Liu C. A low-complexity data-adaptive approach for premature ventricular contraction recognition. Signal Image and Video Processing. 2014; 8(1):111-120. View Publication.
  64. Liu C, Zheng D, Zhao L, Li P, Li B, Murray A, Liu C. Elastic properties of peripheral arteries in heart failure patients in comparison with normal subjects. J Physiol Sci. 2013 May; 63(3):195-201. PMID: 23519698.
    Citations: 2     Fields:    Translation:Humans
  65. Li P, Liu C, Wang X, Li L, Yang L, Chen Y, Liu C. Testing pattern synchronization in coupled systems through different entropy-based measures. Med Biol Eng Comput. 2013 May; 51(5):581-91. PMID: 23337958.
    Citations: 7     Fields:    Translation:Humans
  66. Liu C, Li L, Zhao L, Zheng D, Li P, Liu C. A combination method of improved impulse rejection filter and template matching for identification of anomalous intervals in RR sequences. J Med Biol Eng. 2012; 32(4):245-50.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.