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profileJoseph Geradts, M.D.

TitleMember of the Faculty of Pathology
InstitutionBrigham and Women's Hospital
DepartmentPathology
AddressBrigham and Women's Hospital
75 Francis St
Boston MA 02115
Phone617/732-7510
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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Troester MA, Sun X, Allott EH, Geradts J, Cohen SM, Tse CK, Kirk EL, Thorne LB, Mathews M, Li Y, Hu Z, Robinson WR, Hoadley KA, Olopade OI, Reeder-Hayes KE, Earp HS, Olshan AF, Carey LA, Perou CM. Racial Differences in PAM50 Subtypes in the Carolina Breast Cancer Study. J Natl Cancer Inst. 2018 Feb 01; 110(2). PMID: 28859290.
    View in: PubMed
  2. Sood AK, Geradts J, Young J. Prostate-derived Ets factor, an oncogenic driver in breast cancer. Tumour Biol. 2017 May; 39(5):1010428317691688. PMID: 28468594.
    View in: PubMed
  3. Nichols BS, Llopis A, Palmer GM, McCachren SS, Senlik O, Miller D, Brooke MA, Jokerst NM, Geradts J, Greenup R, Ramanujam N. Miniature spectral imaging device for wide-field quantitative functional imaging of the morphological landscape of breast tumor margins. J Biomed Opt. 2017 02 01; 22(2):26007. PMID: 28241273.
    View in: PubMed
  4. Alfaqih MA, Nelson ER, Liu W, Safi R, Jasper JS, Macias E, Geradts J, Thompson JW, Dubois LG, Freeman MR, Chang CY, Chi JT, McDonnell DP, Freedland SJ. CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer. Cancer Res. 2017 Apr 01; 77(7):1662-1673. PMID: 28130224.
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  5. Taylor NJ, Nikolaishvili-Feinberg N, Midkiff BR, Conway K, Millikan RC, Geradts J. Rational Manual and Automated Scoring Thresholds for the Immunohistochemical Detection of TP53 Missense Mutations in Human Breast Carcinomas. Appl Immunohistochem Mol Morphol. 2016 Jul; 24(6):398-404. PMID: 26200835; PMCID: PMC4716889 [Available on 07/01/17].
  6. Allott EH, Geradts J, Sun X, Cohen SM, Zirpoli GR, Khoury T, Bshara W, Chen M, Sherman ME, Palmer JR, Ambrosone CB, Olshan AF, Troester MA. Intratumoral heterogeneity as a source of discordance in breast cancer biomarker classification. Breast Cancer Res. 2016 Jun 28; 18(1):68. PMID: 27349894; PMCID: PMC4924300.
  7. Kennedy S, Caldwell M, Bydlon T, Mulvey C, Mueller J, Wilke L, Barry W, Ramanujam N, Geradts J. Correlation of breast tissue histology and optical signatures to improve margin assessment techniques. J Biomed Opt. 2016 Jun 01; 21(6):66014. PMID: 27327487; PMCID: PMC4914603 [Available on 06/21/17].
  8. Geradts J, Groth J, Wu Y, Jin G. Validation of an oligo-gene signature for the prognostic stratification of ductal carcinoma in situ (DCIS). Breast Cancer Res Treat. 2016 Jun; 157(3):447-59. PMID: 27250000.
    View in: PubMed
  9. Mueller JL, Gallagher JE, Chitalia R, Krieger M, Erkanli A, Willett RM, Geradts J, Ramanujam N. Rapid staining and imaging of subnuclear features to differentiate between malignant and benign breast tissues at a point-of-care setting. J Cancer Res Clin Oncol. 2016 Jul; 142(7):1475-86. PMID: 27106032; PMCID: PMC4900949 [Available on 07/01/17].
  10. Allott EH, Cohen SM, Geradts J, Sun X, Khoury T, Bshara W, Zirpoli GR, Miller CR, Hwang H, Thorne LB, O'Connor S, Tse CK, Bell MB, Hu Z, Li Y, Kirk EL, Bethea TN, Perou CM, Palmer JR, Ambrosone CB, Olshan AF, Troester MA. Performance of Three-Biomarker Immunohistochemistry for Intrinsic Breast Cancer Subtyping in the AMBER Consortium. Cancer Epidemiol Biomarkers Prev. 2016 Mar; 25(3):470-8. PMID: 26711328; PMCID: PMC4779705 [Available on 03/01/17].
  11. Horton JK, Siamakpour-Reihani S, Lee CT, Zhou Y, Chen W, Geradts J, Fels DR, Hoang P, Ashcraft KA, Groth J, Kung HN, Dewhirst MW, Chi JT. FAS Death Receptor: A Breast Cancer Subtype-Specific Radiation Response Biomarker and Potential Therapeutic Target. Radiat Res. 2015 Nov; 184(5):456-69. PMID: 26488758; PMCID: PMC4671819 [Available on 11/01/16].
  12. Sutton LM, Geradts J, Hamilton EP, Havlin KA, Kimmick GG, Marcom PK, Spector NL, Watson M, Rabin DU, Bruno TO, Noe A, Miller S, Subramaniam C, Layton S, Grichnik K. CHAMBER: A Regional Performance Improvement CME Initiative for Breast Cancer Health Care Providers. J Natl Compr Canc Netw. 2015 Aug; 13(8):1005-11. PMID: 26285246.
    View in: PubMed
  13. Li S, Payne S, Wang F, Claus P, Su Z, Groth J, Geradts J, de Ridder G, Alvarez R, Marcom PK, Pizzo SV, Bachelder RE. Nuclear basic fibroblast growth factor regulates triple-negative breast cancer chemo-resistance. Breast Cancer Res. 2015 Jul 04; 17:91. PMID: 26141457; PMCID: PMC4491247.
  14. Nichols BS, Schindler CE, Brown JQ, Wilke LG, Mulvey CS, Krieger MS, Gallagher J, Geradts J, Greenup RA, Von Windheim JA, Ramanujam N. A Quantitative Diffuse Reflectance Imaging (QDRI) System for Comprehensive Surveillance of the Morphological Landscape in Breast Tumor Margins. PLoS One. 2015; 10(6):e0127525. PMID: 26076123; PMCID: PMC4468201.
  15. Mueller JL, Fu HL, Mito JK, Whitley MJ, Chitalia R, Erkanli A, Dodd L, Cardona DM, Geradts J, Willett RM, Kirsch DG, Ramanujam N. A quantitative microscopic approach to predict local recurrence based on in vivo intraoperative imaging of sarcoma tumor margins. Int J Cancer. 2015 Nov 15; 137(10):2403-12. PMID: 25994353; PMCID: PMC4575838 [Available on 11/15/16].
  16. Horton JK, Blitzblau RC, Yoo S, Geradts J, Chang Z, Baker JA, Georgiade GS, Chen W, Siamakpour-Reihani S, Wang C, Broadwater G, Groth J, Palta M, Dewhirst M, Barry WT, Duffy EA, Chi JT, Hwang ES. Preoperative Single-Fraction Partial Breast Radiation Therapy: A Novel Phase 1, Dose-Escalation Protocol With Radiation Response Biomarkers. Int J Radiat Oncol Biol Phys. 2015 Jul 15; 92(4):846-55. PMID: 26104938; PMCID: PMC4481883 [Available on 07/15/16].
  17. Conway K, Edmiston SN, May R, Kuan PF, Chu H, Bryant C, Tse CK, Swift-Scanlan T, Geradts J, Troester MA, Millikan RC. DNA methylation profiling in the Carolina Breast Cancer Study defines cancer subclasses differing in clinicopathologic characteristics and survival. Breast Cancer Res. 2014 Oct 07; 16(5):450. PMID: 25287138; PMCID: PMC4303129.
  18. Cheng Q, Chang JT, Gwin WR, Zhu J, Ambs S, Geradts J, Lyerly HK. A signature of epithelial-mesenchymal plasticity and stromal activation in primary tumor modulates late recurrence in breast cancer independent of disease subtype. Breast Cancer Res. 2014 Jul 25; 16(4):407. PMID: 25060555; PMCID: PMC4187325.
  19. Henao R, Geradts J, Kurokawa M, Kornbluth S, Lucas JE. Automated, quantitative analysis of histopathological staining in nuclei. AMIA Jt Summits Transl Sci Proc. 2014; 2014:54-9. PMID: 25717401; PMCID: PMC4333705.
  20. Nelson ER, Wardell SE, Jasper JS, Park S, Suchindran S, Howe MK, Carver NJ, Pillai RV, Sullivan PM, Sondhi V, Umetani M, Geradts J, McDonnell DP. 27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology. Science. 2013 Nov 29; 342(6162):1094-8. PMID: 24288332; PMCID: PMC3899689.
  21. Malin D, Strekalova E, Petrovic V, Deal AM, Al Ahmad A, Adamo B, Miller CR, Ugolkov A, Livasy C, Fritchie K, Hamilton E, Blackwell K, Geradts J, Ewend M, Carey L, Shusta EV, Anders CK, Cryns VL. aB-crystallin: a novel regulator of breast cancer metastasis to the brain. Clin Cancer Res. 2014 Jan 01; 20(1):56-67. PMID: 24132917; PMCID: PMC3973485.
  22. Brown JQ, Bydlon TM, Kennedy SA, Caldwell ML, Gallagher JE, Junker M, Wilke LG, Barry WT, Geradts J, Ramanujam N. Optical spectral surveillance of breast tissue landscapes for detection of residual disease in breast tumor margins. PLoS One. 2013; 8(7):e69906. PMID: 23922850; PMCID: PMC3724737.
  23. Mueller JL, Harmany ZT, Mito JK, Kennedy SA, Kim Y, Dodd L, Geradts J, Kirsch DG, Willett RM, Brown JQ, Ramanujam N. Quantitative Segmentation of Fluorescence Microscopy Images of Heterogeneous Tissue: Application to the Detection of Residual Disease in Tumor Margins. PLoS One. 2013; 8(6):e66198. PMID: 23824589; PMCID: PMC3688889.
  24. Kurokawa M, Kim J, Geradts J, Matsuura K, Liu L, Ran X, Xia W, Ribar TJ, Henao R, Dewhirst MW, Kim WJ, Lucas JE, Wang S, Spector NL, Kornbluth S. A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53. Sci Signal. 2013 May 07; 6(274):ra32. PMID: 23652204; PMCID: PMC3770270.
  25. Lyman GH, Baker J, Geradts J, Horton J, Kimmick G, Peppercorn J, Pruitt S, Scheri RP, Hwang ES. Multidisciplinary care of patients with early-stage breast cancer. Surg Oncol Clin N Am. 2013 Apr; 22(2):299-317. PMID: 23453336.
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  26. Bydlon TM, Barry WT, Kennedy SA, Brown JQ, Gallagher JE, Wilke LG, Geradts J, Ramanujam N. Advancing optical imaging for breast margin assessment: an analysis of excisional time, cautery, and patent blue dye on underlying sources of contrast. PLoS One. 2012; 7(12):e51418. PMID: 23251526; PMCID: PMC3519619.
  27. Liao S, Desouki MM, Gaile DP, Shepherd L, Nowak NJ, Conroy J, Barry WT, Geradts J. Differential copy number aberrations in novel candidate genes associated with progression from in situ to invasive ductal carcinoma of the breast. Genes Chromosomes Cancer. 2012 Dec; 51(12):1067-78. PMID: 22887771; PMCID: PMC3465468.
  28. Cheng Q, Chang JT, Geradts J, Neckers LM, Haystead T, Spector NL, Lyerly HK. Amplification and high-level expression of heat shock protein 90 marks aggressive phenotypes of human epidermal growth factor receptor 2 negative breast cancer. Breast Cancer Res. 2012 Apr 17; 14(2):R62. PMID: 22510516; PMCID: PMC3446397.
  29. Adamo B, Deal AM, Burrows E, Geradts J, Hamilton E, Blackwell KL, Livasy C, Fritchie K, Prat A, Harrell JC, Ewend MG, Carey LA, Miller CR, Anders CK. Phosphatidylinositol 3-kinase pathway activation in breast cancer brain metastases. Breast Cancer Res. 2011; 13(6):R125. PMID: 22132754; PMCID: PMC3326567.
  30. Sood AK, Kim H, Geradts J. PDEF in prostate cancer. Prostate. 2012 May 01; 72(6):592-6. PMID: 21796651.
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  31. Cao X, Geradts J, Dewhirst MW, Lo HW. Upregulation of VEGF-A and CD24 gene expression by the tGLI1 transcription factor contributes to the aggressive behavior of breast cancer cells. Oncogene. 2012 Jan 05; 31(1):104-15. PMID: 21666711; PMCID: PMC3175334.
  32. West D, Geradts J, Wahidi M, Roggli V. Endobronchial metastatic breast cancer with pagetoid histology mimicking bronchial pagetoid squamous cell carcinoma in situ. Hum Pathol. 2011 Nov; 42(11):1819-22. PMID: 21663936.
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  33. Desouki MM, Liao S, Conroy J, Nowak NJ, Shepherd L, Gaile DP, Geradts J. The genomic relationship between primary breast carcinomas and their nodal metastases. Cancer Invest. 2011 May; 29(4):300-7. PMID: 21469979.
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  34. Geradts J, de Herreros AG, Su Z, Burchette J, Broadwater G, Bachelder RE. Nuclear Snail1 and nuclear ZEB1 protein expression in invasive and intraductal human breast carcinomas. Hum Pathol. 2011 Aug; 42(8):1125-31. PMID: 21315410; PMCID: PMC3315281.
  35. Pilie PG, Ibarra-Drendall C, Troch MM, Broadwater G, Barry WT, Petricoin EF, Wulfkuhle JD, Liotta LA, Lem S, Baker JC, Stouder A, Ford AC, Wilke LG, Zalles CM, Mehta P, Williams J, Shivraj M, Su Z, Geradts J, Yu D, Seewaldt VL. Protein microarray analysis of mammary epithelial cells from obese and nonobese women at high risk for breast cancer: feasibility data. Cancer Epidemiol Biomarkers Prev. 2011 Mar; 20(3):476-82. PMID: 21242333; PMCID: PMC3051011.
  36. O'Brien KM, Cole SR, Tse CK, Perou CM, Carey LA, Foulkes WD, Dressler LG, Geradts J, Millikan RC. Intrinsic breast tumor subtypes, race, and long-term survival in the Carolina Breast Cancer Study. Clin Cancer Res. 2010 Dec 15; 16(24):6100-10. PMID: 21169259; PMCID: PMC3029098.
  37. Kennedy S, Geradts J, Bydlon T, Brown JQ, Gallagher J, Junker M, Barry W, Ramanujam N, Wilke L. Optical breast cancer margin assessment: an observational study of the effects of tissue heterogeneity on optical contrast. Breast Cancer Res. 2010; 12(6):R91. PMID: 21054873; PMCID: PMC3046432.
  38. Geradts J, Bean SM, Bentley RC, Barry WT. The oncotype DX recurrence score is correlated with a composite index including routinely reported pathobiologic features. Cancer Invest. 2010 Nov; 28(9):969-77. PMID: 20873988.
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  39. Desouki MM, Liao S, Huang H, Conroy J, Nowak NJ, Shepherd L, Gaile DP, Geradts J. Identification of metastasis-associated breast cancer genes using a high-resolution whole genome profiling approach. J Cancer Res Clin Oncol. 2011 May; 137(5):795-809. PMID: 20680643.
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  40. Hutchinson CB, Geradts J. Histiocytoid carcinoma of the male breast. Ann Diagn Pathol. 2011 Jun; 15(3):190-3. PMID: 20952293.
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  41. Bydlon TM, Kennedy SA, Richards LM, Brown JQ, Yu B, Junker MK, Gallagher J, Geradts J, Wilke LG, Ramanujam N. Performance metrics of an optical spectral imaging system for intra-operative assessment of breast tumor margins. Opt Express. 2010 Apr 12; 18(8):8058-76. PMID: 20588651; PMCID: PMC2939901.
  42. Barry WT, Kernagis DN, Dressman HK, Griffis RJ, Hunter JD, Olson JA, Marks JR, Ginsburg GS, Marcom PK, Nevins JR, Geradts J, Datto MB. Intratumor heterogeneity and precision of microarray-based predictors of breast cancer biology and clinical outcome. J Clin Oncol. 2010 May 01; 28(13):2198-206. PMID: 20368555; PMCID: PMC2860437.
  43. Brown JQ, Bydlon TM, Richards LM, Yu B, Kennedy SA, Geradts J, Wilke LG, Junker M, Gallagher J, Barry W, Ramanujam N. Optical assessment of tumor resection margins in the breast. IEEE J Sel Top Quantum Electron. 2010 Mar 01; 16(3):530-544. PMID: 21544237.
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  44. Wilke LG, Brown JQ, Bydlon TM, Kennedy SA, Richards LM, Junker MK, Gallagher J, Barry WT, Geradts J, Ramanujam N. Rapid noninvasive optical imaging of tissue composition in breast tumor margins. Am J Surg. 2009 Oct; 198(4):566-74. PMID: 19800470; PMCID: PMC2764289.
  45. Sood AK, Wang J, Mhawech-Fauceglia P, Jana B, Liang P, Geradts J. Sam-pointed domain containing Ets transcription factor in luminal breast cancer pathogenesis. Cancer Epidemiol Biomarkers Prev. 2009 Jun; 18(6):1899-903. PMID: 19505923.
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  46. Marcom PK, Datto MB, Barry WT, Geradts J, Foster TL, Dressman HK, Olson J, Potti A, Ginsburg G, Nevins JR. Implementation of genomic predictors of chemotherapy response for guiding preoperative therapy in a prospective breast cancer trial. J Clin Oncol. 2009 May 20; 27(15_suppl):11057. PMID: 27963164.
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  47. Geradts J. Re: KAI1/CD82 is a novel target of estrogen receptor-mediated gene repression and downregulated in primary human breast cancer (Int J Cancer 123: 2239-2246, 2008). Int J Cancer. 2009 May 01; 124(9):2243-4; author reply 2245. PMID: 19115215.
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  48. Brown JQ, Wilke LG, Geradts J, Kennedy SA, Palmer GM, Ramanujam N. Quantitative optical spectroscopy: a robust tool for direct measurement of breast cancer vascular oxygenation and total hemoglobin content in vivo. Cancer Res. 2009 Apr 01; 69(7):2919-26. PMID: 19293184; PMCID: PMC2677720.
  49. Ramanujam N, Brown J, Bydlon TM, Kennedy SA, Richards LM, Junker MK, Gallagher J, Barry WT, Wilke LG, Geradts J. Quantitative spectral reflectance imaging device for intraoperative breast tumor margin assessment. Conf Proc IEEE Eng Med Biol Soc. 2009; 2009:6554-6. PMID: 19964903.
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  50. Harvey S, Kohga S, Sait SN, Markus G, Hurd TC, Martinick M, Geradts J, Saxena R, Gibbs JF. Co-expression of urokinase with haptoglobin in human carcinomas. J Surg Res. 2009 Apr; 152(2):189-97. PMID: 19101688.
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  51. Barry WT, Datto M, Geradts J, Foster T, Olson J, Marcom PK, Dressman HK, Nevins JR, Ginsburg G, Potti A. Genomic-based signatures of chemosensitivity and ER/HER2 status in biologic replicate breast cancer samples. J Clin Oncol. 2008 May 20; 26(15_suppl):11068. PMID: 27947719.
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  52. Millikan RC, Newman B, Tse CK, Moorman PG, Conway K, Dressler LG, Smith LV, Labbok MH, Geradts J, Bensen JT, Jackson S, Nyante S, Livasy C, Carey L, Earp HS, Perou CM. Epidemiology of basal-like breast cancer. Breast Cancer Res Treat. 2008 May; 109(1):123-39. PMID: 17578664; PMCID: PMC2443103.
  53. Desouki MM, Geradts J, Milon B, Franklin RB, Costello LC. hZip2 and hZip3 zinc transporters are down regulated in human prostate adenocarcinomatous glands. Mol Cancer. 2007 Jun 05; 6:37. PMID: 17550612; PMCID: PMC1892035.
  54. Sood AK, Saxena R, Groth J, Desouki MM, Cheewakriangkrai C, Rodabaugh KJ, Kasyapa CS, Geradts J. Expression characteristics of prostate-derived Ets factor support a role in breast and prostate cancer progression. Hum Pathol. 2007 Nov; 38(11):1628-38. PMID: 17521701; PMCID: PMC2121591.
  55. Huang H, Sossey-Alaoui K, Beachy SH, Geradts J. The tetraspanin superfamily member NET-6 is a new tumor suppressor gene. J Cancer Res Clin Oncol. 2007 Oct; 133(10):761-9. PMID: 17486367.
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  56. Heller G, Geradts J, Ziegler B, Newsham I, Filipits M, Markis-Ritzinger EM, Kandioler D, Berger W, Stiglbauer W, Depisch D, Pirker R, Zielinski CC, Zöchbauer-Müller S. Downregulation of TSLC1 and DAL-1 expression occurs frequently in breast cancer. Breast Cancer Res Treat. 2007 Jul; 103(3):283-91. PMID: 17260099.
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  57. Javle MM, Yu J, Khoury T, Chadha KS, Chadha KC, Iyer RV, Foster J, Kuvshinoff BW, Gibbs JF, Geradts J, Black JD, Brattain MG. Akt expression may predict favorable prognosis in cholangiocarcinoma. J Gastroenterol Hepatol. 2006 Nov; 21(11):1744-51. PMID: 16984600.
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  58. Yang J, Ramnath N, Moysich KB, Asch HL, Swede H, Alrawi SJ, Huberman J, Geradts J, Brooks JS, Tan D. Prognostic significance of MCM2, Ki-67 and gelsolin in non-small cell lung cancer. BMC Cancer. 2006 Aug 01; 6:203. PMID: 16882345; PMCID: PMC1555597.
  59. Kulkarni S, Saxena S, Watroba N, Groth J, Brady W, Edge S, Geradts J. Prognostic significance of leptin (L) and leptin receptor (OB-R) expression in human breast cancer (BC). J Clin Oncol. 2006 Jun 20; 24(18_suppl):20054. PMID: 27952664.
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  60. Varadarajan R, Das G, Janarthanan B, Desouki M, Kulkarni S, Geradts J. Study of association between p53 mutation and tamoxifen therapy in women with hormone receptor positive invasive ductal cancer. J Clin Oncol. 2006 Jun 20; 24(18_suppl):10630. PMID: 27952408.
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  61. Carey LA, Perou CM, Livasy CA, Dressler LG, Cowan D, Conway K, Karaca G, Troester MA, Tse CK, Edmiston S, Deming SL, Geradts J, Cheang MC, Nielsen TO, Moorman PG, Earp HS, Millikan RC. Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study. JAMA. 2006 Jun 07; 295(21):2492-502. PMID: 16757721.
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  62. Watwe V, Javle M, Lawrence D, Groth J, Iyer R, El-Hajjar D, Geradts J. Cyclooxygenase-2 (COX-2) levels before and after chemotherapy: a study in rectal cancer. Am J Clin Oncol. 2005 Dec; 28(6):560-4. PMID: 16317264.
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  63. Bush E, Geradts J, O'Connor T. An unusual cause of cholecystitis? Am J Clin Oncol. 2005 Oct; 28(5):529-30. PMID: 16199997.
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  64. Lark AL, Livasy CA, Dressler L, Moore DT, Millikan RC, Geradts J, Iacocca M, Cowan D, Little D, Craven RJ, Cance W. High focal adhesion kinase expression in invasive breast carcinomas is associated with an aggressive phenotype. Mod Pathol. 2005 Oct; 18(10):1289-94. PMID: 15861214.
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  65. Varma G, Varma R, Huang H, Pryshchepava A, Groth J, Fleming D, Nowak NJ, McQuaid D, Conroy J, Mahoney M, Moysich K, Falkner KL, Geradts J. Array comparative genomic hybridisation (aCGH) analysis of premenopausal breast cancers from a nuclear fallout area and matched cases from Western New York. Br J Cancer. 2005 Sep 19; 93(6):699-708. PMID: 16222315; PMCID: PMC2361621.
  66. Zöchbauer-Müller S, Fong KM, Geradts J, Xu X, Seidl S, End-Pfützenreuter A, Lang G, Heller G, Zielinski CC, Gazdar AF, Minna JD. Expression of the candidate tumor suppressor gene hSRBC is frequently lost in primary lung cancers with and without DNA methylation. Oncogene. 2005 Sep 15; 24(41):6249-55. PMID: 15940253.
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  67. Conway K, Parrish E, Edmiston SN, Tolbert D, Tse CK, Geradts J, Livasy CA, Singh H, Newman B, Millikan RC. The estrogen receptor-alpha A908G (K303R) mutation occurs at a low frequency in invasive breast tumors: results from a population-based study. Breast Cancer Res. 2005; 7(6):R871-80. PMID: 16280033; PMCID: PMC1410768.
  68. Singh KK, Kulawiec M, Still I, Desouki MM, Geradts J, Matsui S. Inter-genomic cross talk between mitochondria and the nucleus plays an important role in tumorigenesis. Gene. 2005 Jul 18; 354:140-6. PMID: 15979824.
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  69. Huang H, Groth J, Sossey-Alaoui K, Hawthorn L, Beall S, Geradts J. Aberrant expression of novel and previously described cell membrane markers in human breast cancer cell lines and tumors. Clin Cancer Res. 2005 Jun 15; 11(12):4357-64. PMID: 15958618.
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  70. Geradts J. Molecular prediction of recurrence of breast cancer. N Engl J Med. 2005 Apr 14; 352(15):1605-7; author reply 1605-7. PMID: 15829546.
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  71. Yang J, Tan D, Asch HL, Swede H, Bepler G, Geradts J, Moysich KB. Prognostic significance of gelsolin expression level and variability in non-small cell lung cancer. Lung Cancer. 2004 Oct; 46(1):29-42. PMID: 15364130.
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  72. Winston JS, Geradts J, Liu DF, Stomper PC. Microtome shaving radiography: demonstration of loss of mammographic microcalcifications during histologic sectioning. Breast J. 2004 May-Jun; 10(3):200-3. PMID: 15125745.
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  73. Wilkinson NW, Black JD, Roukhadze E, Driscoll D, Smiley S, Hoshi H, Geradts J, Javle M, Brattain M. Epidermal growth factor receptor expression correlates with histologic grade in resected esophageal adenocarcinoma. J Gastrointest Surg. 2004 May-Jun; 8(4):448-53. PMID: 15120370.
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  74. Stomper PC, Geradts J, Edge SB, Levine EG. Mammographic predictors of the presence and size of invasive carcinomas associated with malignant microcalcification lesions without a mass. AJR Am J Roentgenol. 2003 Dec; 181(6):1679-84. PMID: 14627596.
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  75. Rosty C, Geradts J, Sato N, Wilentz RE, Roberts H, Sohn T, Cameron JL, Yeo CJ, Hruban RH, Goggins M. p16 Inactivation in pancreatic intraepithelial neoplasias (PanINs) arising in patients with chronic pancreatitis. Am J Surg Pathol. 2003 Dec; 27(12):1495-501. PMID: 14657708.
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  76. Maitra A, Hansel DE, Argani P, Ashfaq R, Rahman A, Naji A, Deng S, Geradts J, Hawthorne L, House MG, Yeo CJ. Global expression analysis of well-differentiated pancreatic endocrine neoplasms using oligonucleotide microarrays. Clin Cancer Res. 2003 Dec 01; 9(16 Pt 1):5988-95. PMID: 14676124.
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  77. Furberg H, Millikan RC, Geradts J, Gammon MD, Dressler LG, Ambrosone CB, Newman B. Reproductive factors in relation to breast cancer characterized by p53 protein expression (United States). Cancer Causes Control. 2003 Sep; 14(7):609-18. PMID: 14575358.
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  78. Hansel DE, Rahman A, Hidalgo M, Thuluvath PJ, Lillemoe KD, Schulick R, Ku JL, Park JG, Miyazaki K, Ashfaq R, Wistuba II, Varma R, Hawthorne L, Geradts J, Argani P, Maitra A. Identification of novel cellular targets in biliary tract cancers using global gene expression technology. Am J Pathol. 2003 07; 163(1):217-29. PMID: 12819026; PMCID: PMC1868162.
  79. Millikan R, Eaton A, Worley K, Biscocho L, Hodgson E, Huang WY, Geradts J, Iacocca M, Cowan D, Conway K, Dressler L. HER2 codon 655 polymorphism and risk of breast cancer in African Americans and whites. Breast Cancer Res Treat. 2003 Jun; 79(3):355-64. PMID: 12846420.
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  80. Parwani AV, Geradts J, Caspers E, Offerhaus GJ, Yeo CJ, Cameron JL, Klimstra DS, Maitra A, Hruban RH, Argani P. Immunohistochemical and genetic analysis of non-small cell and small cell gallbladder carcinoma and their precursor lesions. Mod Pathol. 2003 Apr; 16(4):299-308. PMID: 12692194.
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  81. Geradts J. Abrogation of the RB-p16 tumor suppressor pathway in human lung cancer. Methods Mol Med. 2003; 74:89-99. PMID: 12415688.
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  82. Bhagat V, Javle M, Geradts J. Carcinoma of the esophagus with mixed basaloid squamous and glandular differentiation: a distinct histological presentation. Int J Gastrointest Cancer. 2003; 34(2-3):139-42. PMID: 15361648.
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  83. Vo QN, Geradts J, Boudreau DA, Bravo JC, Schneider BG. CDKN2A promoter methylation in gastric adenocarcinomas: clinical variables. Hum Pathol. 2002 Dec; 33(12):1200-4. PMID: 12514789.
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  84. Wilson KS, Roberts H, Leek R, Harris AL, Geradts J. Differential gene expression patterns in HER2/neu-positive and -negative breast cancer cell lines and tissues. Am J Pathol. 2002 Oct; 161(4):1171-85. PMID: 12368191; PMCID: PMC1867314.
  85. Furberg H, Millikan RC, Geradts J, Gammon MD, Dressler LG, Ambrosone CB, Newman B. Environmental factors in relation to breast cancer characterized by p53 protein expression. Cancer Epidemiol Biomarkers Prev. 2002 Sep; 11(9):829-35. PMID: 12223426.
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  86. Vo QN, Geradts J, Gulley ML, Boudreau DA, Bravo JC, Schneider BG. Epstein-Barr virus in gastric adenocarcinomas: association with ethnicity and CDKN2A promoter methylation. J Clin Pathol. 2002 Sep; 55(9):669-75. PMID: 12194996; PMCID: PMC1769746.
  87. Conway K, Edmiston SN, Cui L, Drouin SS, Pang J, He M, Tse CK, Geradts J, Dressler L, Liu ET, Millikan R, Newman B. Prevalence and spectrum of p53 mutations associated with smoking in breast cancer. Cancer Res. 2002 Apr 01; 62(7):1987-95. PMID: 11929815.
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  88. Geradts J, Wilentz RE, Roberts H. Immunohistochemical [corrected] detection of the alternate INK4a-encoded tumor suppressor protein p14(ARF) in archival human cancers and cell lines using commercial antibodies: correlation with p16(INK4a) expression. Mod Pathol. 2001 Nov; 14(11):1162-8. PMID: 11706079.
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  89. Maitra A, Roberts H, Weinberg AG, Geradts J. Aberrant expression of tumor suppressor proteins in the Ewing family of tumors. Arch Pathol Lab Med. 2001 Sep; 125(9):1207-12. PMID: 11520274.
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  90. Furberg H, Millikan R, Dressler L, Newman B, Geradts J. Tumor characteristics in African American and white women. Breast Cancer Res Treat. 2001 Jul; 68(1):33-43. PMID: 11678307.
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  91. Zöchbauer-Müller S, Fong KM, Maitra A, Lam S, Geradts J, Ashfaq R, Virmani AK, Milchgrub S, Gazdar AF, Minna JD. 5' CpG island methylation of the FHIT gene is correlated with loss of gene expression in lung and breast cancer. Cancer Res. 2001 May 01; 61(9):3581-5. PMID: 11325823.
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  92. Maitra A, Roberts H, Weinberg AG, Geradts J. Loss of p16(INK4a) expression correlates with decreased survival in pediatric osteosarcomas. Int J Cancer. 2001 Jan 20; 95(1):34-8. PMID: 11241308.
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  93. Zöchbauer-Müller S, Fong KM, Virmani AK, Geradts J, Gazdar AF, Minna JD. Aberrant promoter methylation of multiple genes in non-small cell lung cancers. Cancer Res. 2001 Jan 01; 61(1):249-55. PMID: 11196170.
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  94. Creager AJ, Cohen JA, Geradts J. Aberrant expression of cell-cycle regulatory proteins in human mesenchymal neoplasia. Cancer Detect Prev. 2001; 25(2):123-31. PMID: 11341347.
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  95. Geradts J, Ingram CD. Abnormal expression of cell cycle regulatory proteins in ductal and lobular carcinomas of the breast. Mod Pathol. 2000 Sep; 13(9):945-53. PMID: 11007034.
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  96. Wistuba II, Tomlinson GE, Behrens C, Virmani A, Geradts J, Blum JL, Minna JD, Gazdar AF. Two identical triplet sisters carrying a germline BRCA1 gene mutation acquire very similar breast cancer somatic mutations at multiple other sites throughout the genome. Genes Chromosomes Cancer. 2000 Aug; 28(4):359-69. PMID: 10862044.
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  97. Pisano ED, Johnston RE, Chapman D, Geradts J, Iacocca MV, Livasy CA, Washburn DB, Sayers DE, Zhong Z, Kiss MZ, Thomlinson WC. Human breast cancer specimens: diffraction-enhanced imaging with histologic correlation--improved conspicuity of lesion detail compared with digital radiography. Radiology. 2000 Mar; 214(3):895-901. PMID: 10715065.
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  98. Hilgers W, Groot Koerkamp B, Geradts J, Tang DJ, Yeo CJ, Hruban RH, Kern SE. Genomic FHIT analysis in RER+ and RER- adenocarcinomas of the pancreas. Genes Chromosomes Cancer. 2000 Mar; 27(3):239-43. PMID: 10679912.
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  99. Geradts J, Hruban RH, Schutte M, Kern SE, Maynard R. Immunohistochemical p16INK4a analysis of archival tumors with deletion, hypermethylation, or mutation of the CDKN2/MTS1 gene. A comparison of four commercial antibodies. Appl Immunohistochem Mol Morphol. 2000 Mar; 8(1):71-9. PMID: 10937052.
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  100. Geradts J, Fong KM, Zimmerman PV, Minna JD. Loss of Fhit expression in non-small-cell lung cancer: correlation with molecular genetic abnormalities and clinicopathological features. Br J Cancer. 2000 Mar; 82(6):1191-7. PMID: 10735505; PMCID: PMC2363352.
  101. Schneider BG, Gulley ML, Eagan P, Bravo JC, Mera R, Geradts J. Loss of p16/CDKN2A tumor suppressor protein in gastric adenocarcinoma is associated with Epstein-Barr virus and anatomic location in the body of the stomach. Hum Pathol. 2000 Jan; 31(1):45-50. PMID: 10665912.
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  102. Lombardi DP, Geradts J, Foley JF, Chiao C, Lamb PW, Barrett JC. Loss of KAI1 expression in the progression of colorectal cancer. Cancer Res. 1999 Nov 15; 59(22):5724-31. PMID: 10582691.
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  103. Gehrig PA, Van Le L, Olatidoye B, Geradts J. Estrogen receptor status, determined by immunohistochemistry, as a predictor of the recurrence of stage I endometrial carcinoma. Cancer. 1999 Nov 15; 86(10):2083-9. PMID: 10570435.
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  104. Dressler LG, Geradts J, Burroughs M, Cowan D, Millikan RC, Newman B. Policy guidelines for the utilization of formalin-fixed, paraffin-embedded tissue sections: the UNC SPORE experience. University of North Carolina Specialized Program of Research Excellence. Breast Cancer Res Treat. 1999 Nov; 58(1):31-9. PMID: 10634516.
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  105. Niehans GA, Kratzke RA, Froberg MK, Aeppli DM, Nguyen PL, Geradts J. G1 checkpoint protein and p53 abnormalities occur in most invasive transitional cell carcinomas of the urinary bladder. Br J Cancer. 1999 Jun; 80(8):1175-84. PMID: 10376969; PMCID: PMC2362363.
  106. Geradts J, Maynard R, Birrer MJ, Hendricks D, Abbondanzo SL, Fong KM, Barrett JC, Lombardi DP. Frequent loss of KAI1 expression in squamous and lymphoid neoplasms. An immunohistochemical study of archival tissues. Am J Pathol. 1999 Jun; 154(6):1665-71. PMID: 10362791; PMCID: PMC1866631.
  107. Geradts J, Fong KM, Zimmerman PV, Maynard R, Minna JD. Correlation of abnormal RB, p16ink4a, and p53 expression with 3p loss of heterozygosity, other genetic abnormalities, and clinical features in 103 primary non-small cell lung cancers. Clin Cancer Res. 1999 Apr; 5(4):791-800. PMID: 10213214.
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  108. Wilentz RE, Geradts J, Maynard R, Offerhaus GJ, Kang M, Goggins M, Yeo CJ, Kern SE, Hruban RH. Inactivation of the p16 (INK4A) tumor-suppressor gene in pancreatic duct lesions: loss of intranuclear expression. Cancer Res. 1998 Oct 15; 58(20):4740-4. PMID: 9788631.
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  109. Coxon AB, Ward JM, Geradts J, Otterson GA, Zajac-Kaye M, Kaye FJ. RET cooperates with RB/p53 inactivation in a somatic multi-step model for murine thyroid cancer. Oncogene. 1998 Sep 24; 17(12):1625-8. PMID: 9794240.
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  110. Frizelle SP, Grim J, Zhou J, Gupta P, Curiel DT, Geradts J, Kratzke RA. Re-expression of p16INK4a in mesothelioma cells results in cell cycle arrest, cell death, tumor suppression and tumor regression. Oncogene. 1998 Jun 18; 16(24):3087-95. PMID: 9671387.
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  111. Geradts J, Andriko JW, Abbondanzo SL. Loss of tumor suppressor gene expression in high-grade but not low-grade non-Hodgkin's lymphomas. Am J Clin Pathol. 1998 Jun; 109(6):669-74. PMID: 9620022.
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  112. Gulley ML, Nicholls JM, Schneider BG, Amin MB, Ro JY, Geradts J. Nasopharyngeal carcinomas frequently lack the p16/MTS1 tumor suppressor protein but consistently express the retinoblastoma gene product. Am J Pathol. 1998 Apr; 152(4):865-9. PMID: 9546345; PMCID: PMC1858242.
  113. Cohen JA, Geradts J. Loss of RB and MTS1/CDKN2 (p16) expression in human sarcomas. Hum Pathol. 1997 Aug; 28(8):893-8. PMID: 9269824.
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  114. Schutte M, Hruban RH, Geradts J, Maynard R, Hilgers W, Rabindran SK, Moskaluk CA, Hahn SA, Schwarte-Waldhoff I, Schmiegel W, Baylin SB, Kern SE, Herman JG. Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas. Cancer Res. 1997 Aug 01; 57(15):3126-30. PMID: 9242437.
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  115. Parker MF, Arroyo GF, Geradts J, Sabichi AL, Park RC, Taylor RR, Birrer MJ. Molecular characterization of adenocarcinoma of the cervix. Gynecol Oncol. 1997 Feb; 64(2):242-51. PMID: 9038270.
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  116. Kratzke RA, Greatens TM, Rubins JB, Maddaus MA, Niewoehner DE, Niehans GA, Geradts J. Rb and p16INK4a expression in resected non-small cell lung tumors. Cancer Res. 1996 Aug 01; 56(15):3415-20. PMID: 8758904.
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  117. Geradts J, Wilson PA. High frequency of aberrant p16(INK4A) expression in human breast cancer. Am J Pathol. 1996 Jul; 149(1):15-20. PMID: 8686738; PMCID: PMC1865226.
  118. Geradts J, Kratzke RA, Crush-Stanton S, Wen SF, Lincoln CE. Wild-type and mutant retinoblastoma protein in paraffin sections. Mod Pathol. 1996 Mar; 9(3):339-47. PMID: 8685238.
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  119. Kratzke RA, Otterson GA, Lincoln CE, Ewing S, Oie H, Geradts J, Kaye FJ. Immunohistochemical analysis of the p16INK4 cyclin-dependent kinase inhibitor in malignant mesothelioma. J Natl Cancer Inst. 1995 Dec 20; 87(24):1870-5. PMID: 7494231.
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  120. Geradts J, Kratzke RA, Niehans GA, Lincoln CE. Immunohistochemical detection of the cyclin-dependent kinase inhibitor 2/multiple tumor suppressor gene 1 (CDKN2/MTS1) product p16INK4A in archival human solid tumors: correlation with retinoblastoma protein expression. Cancer Res. 1995 Dec 15; 55(24):6006-11. PMID: 8521382.
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  121. Newman B, Moorman PG, Millikan R, Qaqish BF, Geradts J, Aldrich TE, Liu ET. The Carolina Breast Cancer Study: integrating population-based epidemiology and molecular biology. Breast Cancer Res Treat. 1995 Jul; 35(1):51-60. PMID: 7612904.
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  122. Millikan R, Dressler L, Geradts J, Graham M. The need for epidemiologic studies of in-situ carcinoma of the breast. Breast Cancer Res Treat. 1995 Jul; 35(1):65-77. PMID: 7612906.
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  123. Geradts J, McLendon WW. Pathology and laboratory medicine. JAMA. 1994 Jun 01; 271(21):1700-1. PMID: 8182860.
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  124. Kratzke RA, Otterson GA, Hogg A, Coxon AB, Geradts J, Cowell JK, Kaye FJ. Partial inactivation of the RB product in a family with incomplete penetrance of familial retinoblastoma and benign retinal tumors. Oncogene. 1994 May; 9(5):1321-6. PMID: 8152792.
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  125. Geradts J, Chen JY, Russell EK, Yankaskas JR, Nieves L, Minna JD. Human lung cancer cell lines exhibit resistance to retinoic acid treatment. Cell Growth Differ. 1993 Oct; 4(10):799-809. PMID: 8274449.
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  126. Kratzke RA, Shimizu E, Geradts J, Gerster JL, Segal S, Otterson GA, Kaye FJ. RB-mediated tumor suppression of a lung cancer cell line is abrogated by an extract enriched in extracellular matrix. Cell Growth Differ. 1993 Aug; 4(8):629-35. PMID: 8398904.
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  127. Geradts J, Richards J, Edery M, Pang K, Larson L, Nandi S. Heterogeneity in the hormonal responsiveness of clones derived from the 13762NF rat mammary tumor. Cancer Res. 1986 Apr; 46(4 Pt 2):1920-7. PMID: 3004710.
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