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Basak E. Uygun, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R00DK088962 (UYGUN, BASAK ELIF) Dec 17, 2013 - Nov 30, 2016
    NIH/NIDDK
    Use of Discarded Organs for Preparation of Liver Grafts
    Role: Principal Investigator
  2. K99DK088962 (UYGUN, BASAK ELIF) Sep 1, 2011 - Aug 31, 2013
    NIH/NIDDK
    Use of Discarded Organs for Preparation of Liver Grafts
    Role: Principal Investigator
  3. R01DK084053 (YARMUSH, MARTIN L) Sep 5, 2009 - Aug 31, 2021
    NIH/NIDDK
    Recellularization of Liver Bioscaffolds
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Devalliere J, Chen Y, Dooley K, Yarmush ML, Uygun BE. Improving functional re-endothelialization of acellular liver scaffold using REDV cell-binding domain. Acta Biomater. 2018 09 15; 78:151-164. PMID: 30071351.
    Citations:    Fields:    
  2. Ciccocioppo R, Dos Santos CC, Baumgart DC, Cangemi GC, Cardinale V, Ciacci C, De Coppi P, Haldar D, Klersy C, Nostro MC, Ott M, Piemonti L, Tomei AA, Uygun B, Vetrano S, Orlando G. Proceedings of the signature series event of the international society for cellular therapy: "Advancements in cellular therapies and regenerative medicine in digestive diseases," London, United Kingdom, May 3, 2017. Cytotherapy. 2018 Mar; 20(3):461-476. PMID: 29398624.
    Citations:    Fields:    
  3. Jaramillo M, Yeh H, Yarmush ML, Uygun BE. Decellularized human liver extracellular matrix (hDLM)-mediated hepatic differentiation of human induced pluripotent stem cells (hIPSCs). J Tissue Eng Regen Med. 2018 Apr; 12(4):e1962-e1973. PMID: 29222839.
    Citations:    Fields:    
  4. Chen Y, Geerts S, Jaramillo M, Uygun BE. Preparation of Decellularized Liver Scaffolds and Recellularized Liver Grafts. Methods Mol Biol. 2018; 1577:255-270. PMID: 28735385.
    Citations: 2     Fields:    
  5. Sarier M, Seyman D, Tekin S, Duman I, Uygun B, Demir M, Kukul E, Yavuz AH. Comparision of Ureteral Stent Colonization Between Deceased and Live Donor Renal Transplant Recipients. Transplant Proc. 2017 Nov; 49(9):2082-2085. PMID: 29149965.
    Citations: 1     Fields:    Translation:HumansCells
  6. Devalliere J, Dooley K, Hu Y, Kelangi SS, Uygun BE, Yarmush ML. Co-delivery of a growth factor and a tissue-protective molecule using elastin biopolymers accelerates wound healing in diabetic mice. Biomaterials. 2017 Oct; 141:149-160. PMID: 28688286.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  7. Ochando J, Charron D, Baptista PM, Uygun BE. Immune responses to bioengineered organs. Curr Opin Organ Transplant. 2017 Feb; 22(1):79-85. PMID: 27926545.
    Citations:    Fields:    Translation:Humans
  8. Uygun BE, Izamis ML, Jaramillo M, Chen Y, Price G, Ozer S, Yarmush ML. Discarded Livers Find a New Life: Engineered Liver Grafts Using Hepatocytes Recovered From Marginal Livers. Artif Organs. 2017 Jun; 41(6):579-585. PMID: 27862079.
    Citations:    Fields:    Translation:AnimalsCells
  9. Levy G, Habib N, Guzzardi MA, Kitsberg D, Bomze D, Ezra E, Uygun BE, Uygun K, Trippler M, Schlaak JF, Shibolet O, Sklan EH, Cohen M, Timm J, Friedman N, Nahmias Y. Nuclear receptors control pro-viral and antiviral metabolic responses to hepatitis C virus infection. Nat Chem Biol. 2016 Dec; 12(12):1037-1045. PMID: 27723751.
    Citations: 7     Fields:    Translation:HumansCells
  10. Geerts S, Ozer S, Jaramillo M, Yarmush ML, Uygun BE. Nondestructive Methods for Monitoring Cell Removal During Rat Liver Decellularization. Tissue Eng Part C Methods. 2016 07; 22(7):671-8. PMID: 27169332.
    Citations: 1     Fields:    Translation:Animals
  11. Dooley K, Devalliere J, Uygun BE, Yarmush ML. Functionalized Biopolymer Particles Enhance Performance of a Tissue-Protective Peptide under Proteolytic and Thermal Stress. Biomacromolecules. 2016 06 13; 17(6):2073-9. PMID: 27219509.
    Citations: 1     Fields:    Translation:HumansCells
  12. Golberg A, Bruinsma BG, Jaramillo M, Yarmush ML, Uygun BE. Rat liver regeneration following ablation with irreversible electroporation. PeerJ. 2016; 4:e1571. PMID: 26819842; PMCID: PMC4727979.
    Citations: 7     
  13. Li Q, Uygun BE, Geerts S, Ozer S, Scalf M, Gilpin SE, Ott HC, Yarmush ML, Smith LM, Welham NV, Frey BL. Proteomic analysis of naturally-sourced biological scaffolds. Biomaterials. 2016 Jan; 75:37-46. PMID: 26476196; PMCID: PMC4644483.
    Citations: 15     Fields:    Translation:HumansAnimals
  14. Bruinsma BG, Kim Y, Berendsen TA, Ozer S, Yarmush ML, Uygun BE. Layer-by-layer heparinization of decellularized liver matrices to reduce thrombogenicity of tissue engineered grafts. J Clin Transl Res. 2015; 1(1). PMID: 26478914.
    Citations: 5     
  15. Bruinsma BG, Kim Y, Berendsen TA, Ozer S, Yarmush ML, Uygun BE. Layer-by-layer heparinization of decellularized liver matrices to reduce thrombogenicity of tissue engineered grafts. J Clin Transl Res. 2015 Jul 20; 1(1):48-56. PMID: 30873444.
    Citations:    
  16. Asuman Yavuz H, Tekin S, Yuksel Y, Ates I, Yucetin L, Demir M, Uygun B, Tuncer M, Demirbas A. Donors With Hepatitis B Surface Antigen Positivity. Transplant Proc. 2015 Jun; 47(5):1312-4. PMID: 26093707.
    Citations:    
  17. Bruinsma BG, Avruch JH, Weeder PD, Sridharan GV, Uygun BE, Karimian NG, Porte RJ, Markmann JF, Yeh H, Uygun K. Functional human liver preservation and recovery by means of subnormothermic machine perfusion. J Vis Exp. 2015 Apr 27; (98). PMID: 25938299; PMCID: PMC4420550.
    Citations: 7     Fields:    Translation:Humans
  18. Golberg A, Bruinsma BG, Uygun BE, Yarmush ML. Tissue heterogeneity in structure and conductivity contribute to cell survival during irreversible electroporation ablation by "electric field sinks". Sci Rep. 2015 Feb 16; 5:8485. PMID: 25684630; PMCID: PMC4329566.
    Citations: 18     Fields:    Translation:Animals
  19. Berendsen TA, Bruinsma BG, Puts CF, Saeidi N, Usta OB, Uygun BE, Izamis ML, Toner M, Yarmush ML, Uygun K. Supercooling enables long-term transplantation survival following 4 days of liver preservation. Nat Med. 2014 Jul; 20(7):790-3. PMID: 24973919; PMCID: PMC4141719.
    Citations: 16     Fields:    Translation:Animals
  20. Liu Q, Berendsen T, Izamis ML, Uygun B, Yarmush ML, Uygun K. Perfusion defatting at subnormothermic temperatures in steatotic rat livers. Transplant Proc. 2013 Nov; 45(9):3209-13. PMID: 24182786; PMCID: PMC3843811.
    Citations: 9     Fields:    Translation:Animals
  21. Izamis ML, Tolboom H, Uygun B, Berthiaume F, Yarmush ML, Uygun K. Resuscitation of ischemic donor livers with normothermic machine perfusion: a metabolic flux analysis of treatment in rats. PLoS One. 2013; 8(7):e69758. PMID: 23922793; PMCID: PMC3724866.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  22. Usta OB, Kim Y, Ozer S, Bruinsma BG, Lee J, Demir E, Berendsen TA, Puts CF, Izamis ML, Uygun K, Uygun BE, Yarmush ML. Supercooling as a viable non-freezing cell preservation method of rat hepatocytes. PLoS One. 2013; 8(7):e69334. PMID: 23874947; PMCID: PMC3713052.
    Citations: 9     Fields:    Translation:AnimalsCells
  23. Uygun BE, Yarmush ML. Engineered liver for transplantation. Curr Opin Biotechnol. 2013 Oct; 24(5):893-9. PMID: 23791465; PMCID: PMC3783566.
    Citations: 6     Fields:    Translation:HumansAnimals
  24. Izamis ML, Calhoun C, Uygun BE, Guzzardi MA, Price G, Luitje M, Saeidi N, Yarmush ML, Uygun K. SIMPLE MACHINE PERFUSION SIGNIFICANTLY ENHANCES HEPATOCYTE YIELDS OF ISCHEMIC AND FRESH RAT LIVERS. Cell Med. 2013; 4(3):109-123. PMID: 25431743.
    Citations: 6     
  25. Uygun BE, Yarmush ML, Uygun K. Application of whole-organ tissue engineering in hepatology. Nat Rev Gastroenterol Hepatol. 2012 12; 9(12):738-44. PMID: 22890112; PMCID: PMC3732057.
    Citations: 13     Fields:    Translation:AnimalsCells
  26. Izamis ML, Uygun K, Sharma NS, Uygun B, Yarmush ML, Berthiaume F. Development of Metabolic Indicators of Burn Injury: Very Low Density Lipoprotein (VLDL) and Acetoacetate Are Highly Correlated to Severity of Burn Injury in Rats. Metabolites. 2012 Jul 16; 2(3):458-78. PMID: 24957642; PMCID: PMC3901222.
    Citations: 2     
  27. Perk S, Izamis ML, Tolboom H, Uygun B, Yarmush ML, Uygun K. A fitness index for transplantation of machine-perfused cadaveric rat livers. BMC Res Notes. 2012 Jun 25; 5:325. PMID: 22731806; PMCID: PMC3441584.
    Citations: 10     Fields:    Translation:HumansAnimals
  28. Perk S, Izamis ML, Tolboom H, Uygun B, Berthiaume F, Yarmush ML, Uygun K. A metabolic index of ischemic injury for perfusion-recovery of cadaveric rat livers. PLoS One. 2011; 6(12):e28518. PMID: 22194843; PMCID: PMC3237452.
    Citations: 12     Fields:    Translation:HumansAnimals
  29. Tolboom H, Izamis ML, Sharma N, Milwid JM, Uygun B, Berthiaume F, Uygun K, Yarmush ML. Subnormothermic machine perfusion at both 20°C and 30°C recovers ischemic rat livers for successful transplantation. J Surg Res. 2012 Jun 01; 175(1):149-56. PMID: 21550058; PMCID: PMC3863393.
    Citations: 28     Fields:    Translation:Animals
  30. Uygun BE, Price G, Saedi N, Izamis ML, Berendsen T, Yarmush M, Uygun K. Decellularization and recellularization of whole livers. J Vis Exp. 2011 Feb 04; (48). PMID: 21339718; PMCID: PMC3197392.
    Citations: 8     Fields:    Translation:Animals
  31. Izamis ML, Sharma NS, Uygun B, Bieganski R, Saeidi N, Nahmias Y, Uygun K, Yarmush ML, Berthiaume F. In situ metabolic flux analysis to quantify the liver metabolic response to experimental burn injury. Biotechnol Bioeng. 2011 Apr; 108(4):839-52. PMID: 21404258; PMCID: PMC3277812.
    Citations: 14     Fields:    Translation:AnimalsCells
  32. Uygun K, Uygun B, Matthew HW, Huang Y. Optimization-based metabolic control analysis. Biotechnol Prog. 2010 Nov-Dec; 26(6):1567-79. PMID: 20967921.
    Citations: 2     Fields:    
  33. Uygun K, Tolboom H, Izamis ML, Uygun B, Sharma N, Yagi H, Soto-Gutierrez A, Hertl M, Berthiaume F, Yarmush ML. Diluted blood reperfusion as a model for transplantation of ischemic rat livers: alanine aminotransferase is a direct indicator of viability. Transplant Proc. 2010 Sep; 42(7):2463-7. PMID: 20832525; PMCID: PMC3020900.
    Citations: 8     Fields:    Translation:Animals
  34. Uygun BE, Soto-Gutierrez A, Yagi H, Izamis ML, Guzzardi MA, Shulman C, Milwid J, Kobayashi N, Tilles A, Berthiaume F, Hertl M, Nahmias Y, Yarmush ML, Uygun K. Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix. Nat Med. 2010 Jul; 16(7):814-20. PMID: 20543851; PMCID: PMC2930603.
    Citations: 273     Fields:    Translation:HumansAnimalsCells
  35. Soto-Gutierrez A, Yagi H, Uygun BE, Navarro-Alvarez N, Uygun K, Kobayashi N, Yang YG, Yarmush ML. Cell delivery: from cell transplantation to organ engineering. Cell Transplant. 2010; 19(6):655-65. PMID: 20525441; PMCID: PMC2957541.
    Citations: 20     Fields:    Translation:Animals
  36. Uygun BE, Bou-Akl T, Albanna M, Matthew HW. Membrane thickness is an important variable in membrane scaffolds: Influence of chitosan membrane structure on the behavior of cells. Acta Biomater. 2010 Jun; 6(6):2126-31. PMID: 19925888; PMCID: PMC2862882.
    Citations: 2     Fields:    Translation:AnimalsCells
  37. Roach KL, King KR, Uygun BE, Kohane IS, Yarmush ML, Toner M. High throughput single cell bioinformatics. Biotechnol Prog. 2009 Nov-Dec; 25(6):1772-9. PMID: 19830811; PMCID: PMC3208255.
    Citations: 9     Fields:    Translation:AnimalsCells
  38. Uygun BE, Stojsih SE, Matthew HW. Effects of immobilized glycosaminoglycans on the proliferation and differentiation of mesenchymal stem cells. Tissue Eng Part A. 2009 Nov; 15(11):3499-512. PMID: 19456238; PMCID: PMC2792061.
    Citations: 19     Fields:    Translation:AnimalsCells
  39. Izamis ML, Uygun K, Uygun B, Yarmush ML, Berthiaume F. Effects of burn injury on markers of hypermetabolism in rats. J Burn Care Res. 2009 Nov-Dec; 30(6):993-1001. PMID: 19898103.
    Citations: 7     Fields:    Translation:Animals
  40. Uygun BE, Sharma N, Yarmush M. Retinal pigment epithelium differentiation of stem cells: current status and challenges. Crit Rev Biomed Eng. 2009; 37(4-5):355-75. PMID: 20528731; PMCID: PMC4635560.
    Citations: 1     Fields:    Translation:HumansAnimals
  41. Song Q, Uygun B, Banerjee I, Nahmias Y, Zhang Q, Berthiaume F, Latina M, Yarmush ML. Low Power Laser Irradiation Stimulates the Proliferation of Adult Human Retinal Pigment Epithelial Cells in Culture. Cell Mol Bioeng. 2009 Mar; 2(1):87-103. PMID: 26740823.
    Citations:    
  42. Soto-Gutierrez A, Basma H, Navarro-Alvarez N, Uygun BE, Yarmush ML, Kobayashi N, Fox IJ. Differentiating stem cells into liver. Biotechnol Genet Eng Rev. 2008; 25:149-63. PMID: 21412354.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.