Harvard Catalyst Profiles

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Basak E. Uygun, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R00DK088962 (UYGUN, BASAK ELIF) Dec 17, 2013 - Nov 30, 2017
    Use of Discarded Organs for Preparation of Liver Grafts
    Role: Principal Investigator
  2. K99DK088962 (UYGUN, BASAK ELIF) Sep 1, 2011 - Aug 31, 2013
    Use of Discarded Organs for Preparation of Liver Grafts
    Role: Principal Investigator
  3. R01DK084053 (YARMUSH, MARTIN L) Sep 5, 2009 - Aug 31, 2021
    Recellularization of Liver Bioscaffolds
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Goudot G, Berkane Y, de Clermont-Tonnerre E, Guinier C, Filz von Reiterdank I, van Kampen A, Uygun K, Cetrulo CL, Uygun BE, Dua A, Lellouch AG. Microvascular assessment of fascio-cutaneous flaps by ultrasound: A large animal study. Front Physiol. 2022; 13:1063240. PMID: 36589429; PMCID: PMC9797596.
  2. Oganesyan RV, Lellouch AG, Acun A, Lupon E, Taveau CB, Burlage LC, Lantieri LA, Randolph MA, Cetrulo CL, Uygun BE. Acellular nipple scaffold development, characterization, and preliminary biocompatibility assessment in a swine model. Plast Reconstr Surg. 2022 Dec 06. PMID: 36472499.
    Citations:    Fields:    
  3. Petrosyan A, Martins PN, Solez K, Uygun BE, Gorantla VS, Orlando G. Regenerative medicine applications: An overview of clinical trials. Front Bioeng Biotechnol. 2022; 10:942750. PMID: 36507264; PMCID: PMC9732032.
  4. Acun A, Oganesyan R, Jaramillo M, Yarmush ML, Uygun BE. Human-Origin iPSC-Based Recellularization of Decellularized Whole Rat Livers. Bioengineering (Basel). 2022 May 19; 9(5). PMID: 35621497; PMCID: PMC9137624.
  5. Bulutoglu B, Acun A, Deng SL, Mert S, Lupon E, Lellouch AG, Cetrulo CL, Uygun BE, Yarmush ML. Combinatorial Use of Therapeutic ELP-Based Micelle Particles in Tissue Engineering. Adv Healthc Mater. 2022 07; 11(13):e2102795. PMID: 35373501; PMCID: PMC9262838.
    Citations:    Fields:    Translation:Animals
  6. Pozzo V, Romano G, Goutard M, Lupon E, Tawa P, Acun A, Andrews AR, Taveau CB, Uygun BE, Randolph MA, Cetrulo CL, Lellouch AG. A Reliable Porcine Fascio-Cutaneous Flap Model for Vascularized Composite Allografts Bioengineering Studies. J Vis Exp. 2022 03 31; (181). PMID: 35435906.
    Citations:    Fields:    Translation:HumansAnimals
  7. Lupon E, Lellouch AG, Acun A, Andrews AR, Oganesyan R, Goutard M, Taveau CB, Lantieri LA, Cetrulo CL, Uygun BE. Engineering Vascularized Composite Allografts Using Natural Scaffolds: A Systematic Review. Tissue Eng Part B Rev. 2022 06; 28(3):677-693. PMID: 34238047.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  8. Acun A, Oganesyan R, Uygun K, Yeh H, Yarmush ML, Uygun BE. Liver donor age affects hepatocyte function through age-dependent changes in decellularized liver matrix. Biomaterials. 2021 03; 270:120689. PMID: 33524812; PMCID: PMC7906943.
    Citations: 5     Fields:    Translation:AnimalsCells
  9. Hafiz EOA, Bulutoglu B, Mansy SS, Chen Y, Abu-Taleb H, Soliman SAM, El-Hindawi AAF, Yarmush ML, Uygun BE. Development of liver microtissues with functional biliary ductular network. Biotechnol Bioeng. 2021 01; 118(1):17-29. PMID: 32856740.
    Citations: 2     Fields:    Translation:AnimalsCells
  10. Bulutoglu B, Devalliere J, Deng SL, Acun A, Kelangi SS, Uygun BE, Yarmush ML. Tissue scaffolds functionalized with therapeutic elastin-like biopolymer particles. Biotechnol Bioeng. 2020 05; 117(5):1575-1583. PMID: 31956985.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  11. Chen Y, Devalliere J, Bulutoglu B, Yarmush ML, Uygun BE. Repopulation of intrahepatic bile ducts in engineered rat liver grafts. Technology (Singap World Sci). 2019 Mar-Jun; 7(1-2):46-55. PMID: 31388515; PMCID: PMC6684151.
    Citations: 6     
  12. Bei M, Uygun BE. Editorial: On Tissue Engineering and Regenerative Medicine of Skin and Its Appendages. Front Physiol. 2019; 10:712. PMID: 31244678; PMCID: PMC6579836.
  13. Acun A, Oganesyan R, Uygun BE. Liver Bioengineering: Promise, Pitfalls, and Hurdles to Overcome. Curr Transplant Rep. 2019 Jun; 6(2):119-126. PMID: 31289714; PMCID: PMC6615568.
    Citations: 6     
  14. Devalliere J, Chen Y, Dooley K, Yarmush ML, Uygun BE. Improving functional re-endothelialization of acellular liver scaffold using REDV cell-binding domain. Acta Biomater. 2018 09 15; 78:151-164. PMID: 30071351; PMCID: PMC6261340.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  15. Ciccocioppo R, Dos Santos CC, Baumgart DC, Cangemi GC, Cardinale V, Ciacci C, De Coppi P, Haldar D, Klersy C, Nostro MC, Ott M, Piemonti L, Tomei AA, Uygun B, Vetrano S, Orlando G. Proceedings of the signature series event of the international society for cellular therapy: "Advancements in cellular therapies and regenerative medicine in digestive diseases," London, United Kingdom, May 3, 2017. Cytotherapy. 2018 03; 20(3):461-476. PMID: 29398624; PMCID: PMC6771025.
    Citations: 1     Fields:    Translation:Humans
  16. Jaramillo M, Yeh H, Yarmush ML, Uygun BE. Decellularized human liver extracellular matrix (hDLM)-mediated hepatic differentiation of human induced pluripotent stem cells (hIPSCs). J Tissue Eng Regen Med. 2018 04; 12(4):e1962-e1973. PMID: 29222839.
    Citations: 18     Fields:    Translation:HumansCells
  17. Chen Y, Geerts S, Jaramillo M, Uygun BE. Preparation of Decellularized Liver Scaffolds and Recellularized Liver Grafts. Methods Mol Biol. 2018; 1577:255-270. PMID: 28735385; PMCID: PMC6688852.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  18. Sarier M, Seyman D, Tekin S, Duman I, Uygun B, Demir M, Kukul E, Yavuz AH. Comparision of Ureteral Stent Colonization Between Deceased and Live Donor Renal Transplant Recipients. Transplant Proc. 2017 Nov; 49(9):2082-2085. PMID: 29149965.
    Citations: 3     Fields:    Translation:HumansCells
  19. Devalliere J, Dooley K, Hu Y, Kelangi SS, Uygun BE, Yarmush ML. Co-delivery of a growth factor and a tissue-protective molecule using elastin biopolymers accelerates wound healing in diabetic mice. Biomaterials. 2017 Oct; 141:149-160. PMID: 28688286.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  20. Ochando J, Charron D, Baptista PM, Uygun BE. Immune responses to bioengineered organs. Curr Opin Organ Transplant. 2017 Feb; 22(1):79-85. PMID: 27926545.
    Citations: 4     Fields:    Translation:Humans
  21. Uygun BE, Izamis ML, Jaramillo M, Chen Y, Price G, Ozer S, Yarmush ML. Discarded Livers Find a New Life: Engineered Liver Grafts Using Hepatocytes Recovered From Marginal Livers. Artif Organs. 2017 Jun; 41(6):579-585. PMID: 27862079; PMCID: PMC5702548.
    Citations: 6     Fields:    Translation:AnimalsCells
  22. Levy G, Habib N, Guzzardi MA, Kitsberg D, Bomze D, Ezra E, Uygun BE, Uygun K, Trippler M, Schlaak JF, Shibolet O, Sklan EH, Cohen M, Timm J, Friedman N, Nahmias Y. Nuclear receptors control pro-viral and antiviral metabolic responses to hepatitis C virus infection. Nat Chem Biol. 2016 Dec; 12(12):1037-1045. PMID: 27723751; PMCID: PMC7046487.
    Citations: 24     Fields:    Translation:HumansCells
  23. Geerts S, Ozer S, Jaramillo M, Yarmush ML, Uygun BE. Nondestructive Methods for Monitoring Cell Removal During Rat Liver Decellularization. Tissue Eng Part C Methods. 2016 07; 22(7):671-8. PMID: 27169332; PMCID: PMC4943465.
    Citations: 11     Fields:    Translation:Animals
  24. Dooley K, Devalliere J, Uygun BE, Yarmush ML. Functionalized Biopolymer Particles Enhance Performance of a Tissue-Protective Peptide under Proteolytic and Thermal Stress. Biomacromolecules. 2016 06 13; 17(6):2073-9. PMID: 27219509.
    Citations: 4     Fields:    Translation:HumansCells
  25. Golberg A, Bruinsma BG, Jaramillo M, Yarmush ML, Uygun BE. Rat liver regeneration following ablation with irreversible electroporation. PeerJ. 2016; 4:e1571. PMID: 26819842; PMCID: PMC4727979.
    Citations: 18     
  26. Li Q, Uygun BE, Geerts S, Ozer S, Scalf M, Gilpin SE, Ott HC, Yarmush ML, Smith LM, Welham NV, Frey BL. Proteomic analysis of naturally-sourced biological scaffolds. Biomaterials. 2016 Jan; 75:37-46. PMID: 26476196.
    Citations: 38     Fields:    Translation:HumansAnimals
  27. Bruinsma BG, Kim Y, Berendsen TA, Ozer S, Yarmush ML, Uygun BE. Layer-by-layer heparinization of decellularized liver matrices to reduce thrombogenicity of tissue engineered grafts. J Clin Transl Res. 2015; 1(1). PMID: 26478914.
    Citations: 5     
  28. Bruinsma BG, Kim Y, Berendsen TA, Ozer S, Yarmush ML, Uygun BE. Layer-by-layer heparinization of decellularized liver matrices to reduce thrombogenicity of tissue engineered grafts. J Clin Transl Res. 2015 Jul 20; 1(1):48-56. PMID: 30873444; PMCID: PMC4607069.
    Citations: 16     
  29. Asuman Yavuz H, Tekin S, Yuksel Y, Ates I, Yucetin L, Demir M, Uygun B, Tuncer M, Demirbas A. Donors With Hepatitis B Surface Antigen Positivity. Transplant Proc. 2015 Jun; 47(5):1312-4. PMID: 26093707.
    Citations: 3     Fields:    Translation:Humans
  30. Bruinsma BG, Avruch JH, Weeder PD, Sridharan GV, Uygun BE, Karimian NG, Porte RJ, Markmann JF, Yeh H, Uygun K. Functional human liver preservation and recovery by means of subnormothermic machine perfusion. J Vis Exp. 2015 Apr 27; (98). PMID: 25938299.
    Citations: 11     Fields:    Translation:Humans
  31. Golberg A, Bruinsma BG, Uygun BE, Yarmush ML. Tissue heterogeneity in structure and conductivity contribute to cell survival during irreversible electroporation ablation by "electric field sinks". Sci Rep. 2015 Feb 16; 5:8485. PMID: 25684630.
    Citations: 38     Fields:    Translation:Animals
  32. Berendsen TA, Bruinsma BG, Puts CF, Saeidi N, Usta OB, Uygun BE, Izamis ML, Toner M, Yarmush ML, Uygun K. Supercooling enables long-term transplantation survival following 4 days of liver preservation. Nat Med. 2014 Jul; 20(7):790-3. PMID: 24973919.
    Citations: 44     Fields:    Translation:Animals
  33. Liu Q, Berendsen T, Izamis ML, Uygun B, Yarmush ML, Uygun K. Perfusion defatting at subnormothermic temperatures in steatotic rat livers. Transplant Proc. 2013 Nov; 45(9):3209-13. PMID: 24182786.
    Citations: 19     Fields:    Translation:Animals
  34. Izamis ML, Tolboom H, Uygun B, Berthiaume F, Yarmush ML, Uygun K. Resuscitation of ischemic donor livers with normothermic machine perfusion: a metabolic flux analysis of treatment in rats. PLoS One. 2013; 8(7):e69758. PMID: 23922793.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  35. Usta OB, Kim Y, Ozer S, Bruinsma BG, Lee J, Demir E, Berendsen TA, Puts CF, Izamis ML, Uygun K, Uygun BE, Yarmush ML. Supercooling as a viable non-freezing cell preservation method of rat hepatocytes. PLoS One. 2013; 8(7):e69334. PMID: 23874947.
    Citations: 16     Fields:    Translation:AnimalsCells
  36. Uygun BE, Yarmush ML. Engineered liver for transplantation. Curr Opin Biotechnol. 2013 Oct; 24(5):893-9. PMID: 23791465.
    Citations: 11     Fields:    Translation:HumansAnimals
  37. Izamis ML, Calhoun C, Uygun BE, Guzzardi MA, Price G, Luitje M, Saeidi N, Yarmush ML, Uygun K. SIMPLE MACHINE PERFUSION SIGNIFICANTLY ENHANCES HEPATOCYTE YIELDS OF ISCHEMIC AND FRESH RAT LIVERS. Cell Med. 2013; 4(3):109-123. PMID: 25431743; PMCID: PMC4243527.
    Citations: 7     
  38. Uygun BE, Yarmush ML, Uygun K. Application of whole-organ tissue engineering in hepatology. Nat Rev Gastroenterol Hepatol. 2012 12; 9(12):738-44. PMID: 22890112.
    Citations: 24     Fields:    Translation:AnimalsCells
  39. Izamis ML, Uygun K, Sharma NS, Uygun B, Yarmush ML, Berthiaume F. Development of Metabolic Indicators of Burn Injury: Very Low Density Lipoprotein (VLDL) and Acetoacetate Are Highly Correlated to Severity of Burn Injury in Rats. Metabolites. 2012 Jul 16; 2(3):458-78. PMID: 24957642.
    Citations: 4     
  40. Perk S, Izamis ML, Tolboom H, Uygun B, Yarmush ML, Uygun K. A fitness index for transplantation of machine-perfused cadaveric rat livers. BMC Res Notes. 2012 Jun 25; 5:325. PMID: 22731806.
    Citations: 13     Fields:    Translation:HumansAnimals
  41. Perk S, Izamis ML, Tolboom H, Uygun B, Berthiaume F, Yarmush ML, Uygun K. A metabolic index of ischemic injury for perfusion-recovery of cadaveric rat livers. PLoS One. 2011; 6(12):e28518. PMID: 22194843.
    Citations: 17     Fields:    Translation:HumansAnimals
  42. Tolboom H, Izamis ML, Sharma N, Milwid JM, Uygun B, Berthiaume F, Uygun K, Yarmush ML. Subnormothermic machine perfusion at both 20°C and 30°C recovers ischemic rat livers for successful transplantation. J Surg Res. 2012 Jun 01; 175(1):149-56. PMID: 21550058.
    Citations: 39     Fields:    Translation:Animals
  43. Uygun BE, Price G, Saedi N, Izamis ML, Berendsen T, Yarmush M, Uygun K. Decellularization and recellularization of whole livers. J Vis Exp. 2011 Feb 04; (48). PMID: 21339718.
    Citations: 14     Fields:    Translation:Animals
  44. Izamis ML, Sharma NS, Uygun B, Bieganski R, Saeidi N, Nahmias Y, Uygun K, Yarmush ML, Berthiaume F. In situ metabolic flux analysis to quantify the liver metabolic response to experimental burn injury. Biotechnol Bioeng. 2011 Apr; 108(4):839-52. PMID: 21404258.
    Citations: 18     Fields:    Translation:AnimalsCells
  45. Uygun K, Uygun B, Matthew HW, Huang Y. Optimization-based metabolic control analysis. Biotechnol Prog. 2010 Nov-Dec; 26(6):1567-79. PMID: 20967921.
    Citations: 2     Fields:    
  46. Uygun K, Tolboom H, Izamis ML, Uygun B, Sharma N, Yagi H, Soto-Gutierrez A, Hertl M, Berthiaume F, Yarmush ML. Diluted blood reperfusion as a model for transplantation of ischemic rat livers: alanine aminotransferase is a direct indicator of viability. Transplant Proc. 2010 Sep; 42(7):2463-7. PMID: 20832525.
    Citations: 12     Fields:    Translation:Animals
  47. Uygun BE, Soto-Gutierrez A, Yagi H, Izamis ML, Guzzardi MA, Shulman C, Milwid J, Kobayashi N, Tilles A, Berthiaume F, Hertl M, Nahmias Y, Yarmush ML, Uygun K. Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix. Nat Med. 2010 Jul; 16(7):814-20. PMID: 20543851.
    Citations: 407     Fields:    Translation:HumansAnimalsCells
  48. Soto-Gutierrez A, Yagi H, Uygun BE, Navarro-Alvarez N, Uygun K, Kobayashi N, Yang YG, Yarmush ML. Cell delivery: from cell transplantation to organ engineering. Cell Transplant. 2010; 19(6):655-65. PMID: 20525441.
    Citations: 22     Fields:    Translation:Animals
  49. Uygun BE, Bou-Akl T, Albanna M, Matthew HW. Membrane thickness is an important variable in membrane scaffolds: Influence of chitosan membrane structure on the behavior of cells. Acta Biomater. 2010 Jun; 6(6):2126-31. PMID: 19925888.
    Citations: 5     Fields:    Translation:AnimalsCells
  50. Izamis ML, Uygun K, Uygun B, Yarmush ML, Berthiaume F. Effects of burn injury on markers of hypermetabolism in rats. J Burn Care Res. 2009 Nov-Dec; 30(6):993-1001. PMID: 19898103.
    Citations: 7     Fields:    Translation:Animals
  51. Uygun BE, Stojsih SE, Matthew HW. Effects of immobilized glycosaminoglycans on the proliferation and differentiation of mesenchymal stem cells. Tissue Eng Part A. 2009 Nov; 15(11):3499-512. PMID: 19456238.
    Citations: 34     Fields:    Translation:AnimalsCells
  52. Roach KL, King KR, Uygun BE, Kohane IS, Yarmush ML, Toner M. High throughput single cell bioinformatics. Biotechnol Prog. 2009 Nov-Dec; 25(6):1772-9. PMID: 19830811.
    Citations: 12     Fields:    Translation:AnimalsCells
  53. Uygun BE, Sharma N, Yarmush M. Retinal pigment epithelium differentiation of stem cells: current status and challenges. Crit Rev Biomed Eng. 2009; 37(4-5):355-75. PMID: 20528731.
    Citations: 2     Fields:    Translation:HumansAnimals
  54. Song Q, Uygun B, Banerjee I, Nahmias Y, Zhang Q, Berthiaume F, Latina M, Yarmush ML. Low Power Laser Irradiation Stimulates the Proliferation of Adult Human Retinal Pigment Epithelial Cells in Culture. Cell Mol Bioeng. 2009 Mar; 2(1):87-103. PMID: 26740823; PMCID: PMC4698896.
    Citations: 1     
  55. Soto-Gutierrez A, Basma H, Navarro-Alvarez N, Uygun BE, Yarmush ML, Kobayashi N, Fox IJ. Differentiating stem cells into liver. Biotechnol Genet Eng Rev. 2008; 25:149-63. PMID: 21412354.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.