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Basak E. Uygun, Ph.D.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R00DK088962 (UYGUN, BASAK ELIF) Dec 17, 2013 - Nov 30, 2016
    NIH/NIDDK
    Use of Discarded Organs for Preparation of Liver Grafts
    Role: Principal Investigator
  2. K99DK088962 (UYGUN, BASAK ELIF) Sep 1, 2011 - Aug 31, 2013
    NIH/NIDDK
    Use of Discarded Organs for Preparation of Liver Grafts
    Role: Principal Investigator
  3. R01DK084053 (YARMUSH, MARTIN L) Sep 5, 2009 - Aug 31, 2021
    NIH/NIDDK
    Recellularization of Liver Bioscaffolds
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Devalliere J, Chen Y, Dooley K, Yarmush ML, Uygun BE. Improving functional re-endothelialization of acellular liver scaffold using REDV cell-binding domain. Acta Biomater. 2018 Sep 15; 78:151-164. PMID: 30071351.
    View in: PubMed
  2. Ciccocioppo R, Dos Santos CC, Baumgart DC, Cangemi GC, Cardinale V, Ciacci C, De Coppi P, Haldar D, Klersy C, Nostro MC, Ott M, Piemonti L, Tomei AA, Uygun B, Vetrano S, Orlando G. Proceedings of the signature series event of the international society for cellular therapy: "Advancements in cellular therapies and regenerative medicine in digestive diseases," London, United Kingdom, May 3, 2017. Cytotherapy. 2018 Mar; 20(3):461-476. PMID: 29398624.
    View in: PubMed
  3. Jaramillo M, Yeh H, Yarmush ML, Uygun BE. Decellularized human liver extracellular matrix (hDLM)-mediated hepatic differentiation of human induced pluripotent stem cells (hIPSCs). J Tissue Eng Regen Med. 2018 Apr; 12(4):e1962-e1973. PMID: 29222839.
    View in: PubMed
  4. Sarier M, Seyman D, Tekin S, Duman I, Uygun B, Demir M, Kukul E, Yavuz AH. Comparision of Ureteral Stent Colonization Between Deceased and Live Donor Renal Transplant Recipients. Transplant Proc. 2017 Nov; 49(9):2082-2085. PMID: 29149965.
    View in: PubMed
  5. Chen Y, Geerts S, Jaramillo M, Uygun BE. Preparation of Decellularized Liver Scaffolds and Recellularized Liver Grafts. Methods Mol Biol. 2017 Jul 23. PMID: 28735385.
    View in: PubMed
  6. Devalliere J, Dooley K, Hu Y, Kelangi SS, Uygun BE, Yarmush ML. Co-delivery of a growth factor and a tissue-protective molecule using elastin biopolymers accelerates wound healing in diabetic mice. Biomaterials. 2017 Oct; 141:149-160. PMID: 28688286.
    View in: PubMed
  7. Ochando J, Charron D, Baptista PM, Uygun BE. Immune responses to bioengineered organs. Curr Opin Organ Transplant. 2017 Feb; 22(1):79-85. PMID: 27926545.
    View in: PubMed
  8. Uygun BE, Izamis ML, Jaramillo M, Chen Y, Price G, Ozer S, Yarmush ML. Discarded Livers Find a New Life: Engineered Liver Grafts Using Hepatocytes Recovered From Marginal Livers. Artif Organs. 2017 Jun; 41(6):579-585. PMID: 27862079.
    View in: PubMed
  9. Levy G, Habib N, Guzzardi MA, Kitsberg D, Bomze D, Ezra E, Uygun BE, Uygun K, Trippler M, Schlaak JF, Shibolet O, Sklan EH, Cohen M, Timm J, Friedman N, Nahmias Y. Nuclear receptors control pro-viral and antiviral metabolic responses to hepatitis C virus infection. Nat Chem Biol. 2016 Dec; 12(12):1037-1045. PMID: 27723751.
    View in: PubMed
  10. Geerts S, Ozer S, Jaramillo M, Yarmush ML, Uygun BE. Nondestructive Methods for Monitoring Cell Removal During Rat Liver Decellularization. Tissue Eng Part C Methods. 2016 07; 22(7):671-8. PMID: 27169332; PMCID: PMC4943465 [Available on 07/01/17].
  11. Dooley K, Devalliere J, Uygun BE, Yarmush ML. Functionalized Biopolymer Particles Enhance Performance of a Tissue-Protective Peptide under Proteolytic and Thermal Stress. Biomacromolecules. 2016 06 13; 17(6):2073-9. PMID: 27219509.
    View in: PubMed
  12. Golberg A, Bruinsma BG, Jaramillo M, Yarmush ML, Uygun BE. Rat liver regeneration following ablation with irreversible electroporation. PeerJ. 2016; 4:e1571. PMID: 26819842; PMCID: PMC4727979.
  13. Li Q, Uygun BE, Geerts S, Ozer S, Scalf M, Gilpin SE, Ott HC, Yarmush ML, Smith LM, Welham NV, Frey BL. Proteomic analysis of naturally-sourced biological scaffolds. Biomaterials. 2016 Jan; 75:37-46. PMID: 26476196; PMCID: PMC4644483 [Available on 01/01/17].
  14. Bruinsma BG, Kim Y, Berendsen TA, Ozer S, Yarmush ML, Uygun BE. Layer-by-layer heparinization of decellularized liver matrices to reduce thrombogenicity of tissue engineered grafts. J Clin Transl Res. 2015; 1(1). PMID: 26478914.
    View in: PubMed
  15. Asuman Yavuz H, Tekin S, Yuksel Y, Ates I, Yucetin L, Demir M, Uygun B, Tuncer M, Demirbas A. Donors With Hepatitis B Surface Antigen Positivity. Transplant Proc. 2015 Jun; 47(5):1312-4. PMID: 26093707.
    View in: PubMed
  16. Bruinsma BG, Avruch JH, Weeder PD, Sridharan GV, Uygun BE, Karimian NG, Porte RJ, Markmann JF, Yeh H, Uygun K. Functional human liver preservation and recovery by means of subnormothermic machine perfusion. J Vis Exp. 2015 Apr 27; (98). PMID: 25938299; PMCID: PMC4420550.
  17. Golberg A, Bruinsma BG, Uygun BE, Yarmush ML. Tissue heterogeneity in structure and conductivity contribute to cell survival during irreversible electroporation ablation by "electric field sinks". Sci Rep. 2015 Feb 16; 5:8485. PMID: 25684630; PMCID: PMC4329566.
  18. Berendsen TA, Bruinsma BG, Puts CF, Saeidi N, Usta OB, Uygun BE, Izamis ML, Toner M, Yarmush ML, Uygun K. Supercooling enables long-term transplantation survival following 4 days of liver preservation. Nat Med. 2014 Jul; 20(7):790-3. PMID: 24973919; PMCID: PMC4141719.
  19. Liu Q, Berendsen T, Izamis ML, Uygun B, Yarmush ML, Uygun K. Perfusion defatting at subnormothermic temperatures in steatotic rat livers. Transplant Proc. 2013 Nov; 45(9):3209-13. PMID: 24182786; PMCID: PMC3843811.
  20. Izamis ML, Tolboom H, Uygun B, Berthiaume F, Yarmush ML, Uygun K. Resuscitation of ischemic donor livers with normothermic machine perfusion: a metabolic flux analysis of treatment in rats. PLoS One. 2013; 8(7):e69758. PMID: 23922793; PMCID: PMC3724866.
  21. Usta OB, Kim Y, Ozer S, Bruinsma BG, Lee J, Demir E, Berendsen TA, Puts CF, Izamis ML, Uygun K, Uygun BE, Yarmush ML. Supercooling as a viable non-freezing cell preservation method of rat hepatocytes. PLoS One. 2013; 8(7):e69334. PMID: 23874947; PMCID: PMC3713052.
  22. Uygun BE, Yarmush ML. Engineered liver for transplantation. Curr Opin Biotechnol. 2013 Oct; 24(5):893-9. PMID: 23791465; PMCID: PMC3783566.
  23. Izamis ML, Calhoun C, Uygun BE, Guzzardi MA, Price G, Luitje M, Saeidi N, Yarmush ML, Uygun K. SIMPLE MACHINE PERFUSION SIGNIFICANTLY ENHANCES HEPATOCYTE YIELDS OF ISCHEMIC AND FRESH RAT LIVERS. Cell Med. 2013; 4(3):109-123. PMID: 25431743.
    View in: PubMed
  24. Uygun BE, Yarmush ML, Uygun K. Application of whole-organ tissue engineering in hepatology. Nat Rev Gastroenterol Hepatol. 2012 12; 9(12):738-44. PMID: 22890112; PMCID: PMC3732057.
  25. Izamis ML, Uygun K, Sharma NS, Uygun B, Yarmush ML, Berthiaume F. Development of Metabolic Indicators of Burn Injury: Very Low Density Lipoprotein (VLDL) and Acetoacetate Are Highly Correlated to Severity of Burn Injury in Rats. Metabolites. 2012 Jul 16; 2(3):458-78. PMID: 24957642; PMCID: PMC3901222.
  26. Perk S, Izamis ML, Tolboom H, Uygun B, Yarmush ML, Uygun K. A fitness index for transplantation of machine-perfused cadaveric rat livers. BMC Res Notes. 2012 Jun 25; 5:325. PMID: 22731806; PMCID: PMC3441584.
  27. Perk S, Izamis ML, Tolboom H, Uygun B, Berthiaume F, Yarmush ML, Uygun K. A metabolic index of ischemic injury for perfusion-recovery of cadaveric rat livers. PLoS One. 2011; 6(12):e28518. PMID: 22194843; PMCID: PMC3237452.
  28. Tolboom H, Izamis ML, Sharma N, Milwid JM, Uygun B, Berthiaume F, Uygun K, Yarmush ML. Subnormothermic machine perfusion at both 20°C and 30°C recovers ischemic rat livers for successful transplantation. J Surg Res. 2012 Jun 01; 175(1):149-56. PMID: 21550058; PMCID: PMC3863393.
  29. Uygun BE, Price G, Saedi N, Izamis ML, Berendsen T, Yarmush M, Uygun K. Decellularization and recellularization of whole livers. J Vis Exp. 2011 Feb 04; (48). PMID: 21339718; PMCID: PMC3197392.
  30. Izamis ML, Sharma NS, Uygun B, Bieganski R, Saeidi N, Nahmias Y, Uygun K, Yarmush ML, Berthiaume F. In situ metabolic flux analysis to quantify the liver metabolic response to experimental burn injury. Biotechnol Bioeng. 2011 Apr; 108(4):839-52. PMID: 21404258; PMCID: PMC3277812.
  31. Uygun K, Uygun B, Matthew HW, Huang Y. Optimization-based metabolic control analysis. Biotechnol Prog. 2010 Nov-Dec; 26(6):1567-79. PMID: 20967921.
    View in: PubMed
  32. Uygun K, Tolboom H, Izamis ML, Uygun B, Sharma N, Yagi H, Soto-Gutierrez A, Hertl M, Berthiaume F, Yarmush ML. Diluted blood reperfusion as a model for transplantation of ischemic rat livers: alanine aminotransferase is a direct indicator of viability. Transplant Proc. 2010 Sep; 42(7):2463-7. PMID: 20832525; PMCID: PMC3020900.
  33. Uygun BE, Soto-Gutierrez A, Yagi H, Izamis ML, Guzzardi MA, Shulman C, Milwid J, Kobayashi N, Tilles A, Berthiaume F, Hertl M, Nahmias Y, Yarmush ML, Uygun K. Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix. Nat Med. 2010 Jul; 16(7):814-20. PMID: 20543851; PMCID: PMC2930603.
  34. Soto-Gutierrez A, Yagi H, Uygun BE, Navarro-Alvarez N, Uygun K, Kobayashi N, Yang YG, Yarmush ML. Cell delivery: from cell transplantation to organ engineering. Cell Transplant. 2010; 19(6):655-65. PMID: 20525441; PMCID: PMC2957541.
  35. Uygun BE, Bou-Akl T, Albanna M, Matthew HW. Membrane thickness is an important variable in membrane scaffolds: Influence of chitosan membrane structure on the behavior of cells. Acta Biomater. 2010 Jun; 6(6):2126-31. PMID: 19925888; PMCID: PMC2862882.
  36. Roach KL, King KR, Uygun BE, Kohane IS, Yarmush ML, Toner M. High throughput single cell bioinformatics. Biotechnol Prog. 2009 Nov-Dec; 25(6):1772-9. PMID: 19830811; PMCID: PMC3208255.
  37. Uygun BE, Stojsih SE, Matthew HW. Effects of immobilized glycosaminoglycans on the proliferation and differentiation of mesenchymal stem cells. Tissue Eng Part A. 2009 Nov; 15(11):3499-512. PMID: 19456238; PMCID: PMC2792061.
  38. Izamis ML, Uygun K, Uygun B, Yarmush ML, Berthiaume F. Effects of burn injury on markers of hypermetabolism in rats. J Burn Care Res. 2009 Nov-Dec; 30(6):993-1001. PMID: 19898103.
    View in: PubMed
  39. Uygun BE, Sharma N, Yarmush M. Retinal pigment epithelium differentiation of stem cells: current status and challenges. Crit Rev Biomed Eng. 2009; 37(4-5):355-75. PMID: 20528731; PMCID: PMC4635560.
  40. Song Q, Uygun B, Banerjee I, Nahmias Y, Zhang Q, Berthiaume F, Latina M, Yarmush ML. Low Power Laser Irradiation Stimulates the Proliferation of Adult Human Retinal Pigment Epithelial Cells in Culture. Cell Mol Bioeng. 2009 Mar; 2(1):87-103. PMID: 26740823.
    View in: PubMed
  41. Soto-Gutierrez A, Basma H, Navarro-Alvarez N, Uygun BE, Yarmush ML, Kobayashi N, Fox IJ. Differentiating stem cells into liver. Biotechnol Genet Eng Rev. 2008; 25:149-63. PMID: 21412354.
    View in: PubMed
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.