Harvard Catalyst Profiles

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Jerrold R Turner, M.D., Ph.D.

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Overview

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R56DK094954 (MILLER, LAWRENCE) Sep 21, 2012 - Aug 31, 2014
    NIH
    HTS ASSAYS FOR INHIBITORS OF PROTEIN INTERACTIONS INCLUDING MLCK1-FKBP8
    Role: Co-Principal Investigator
  2. S10RR025643 (TURNER, JERROLD R.) Jul 16, 2010 - Jul 15, 2011
    NIH
    Advanced Multi-color Confocal and FRAP-SAC Microscope
    Role: Principal Investigator
  3. P01DK067887 (HECHT, GAIL A.) Dec 1, 2005 - Jul 31, 2012
    NIH/NIDDK
    Regulation of Intestinal Transport
    Role: Co-Principal Investigator
  4. R01DK068271 (TURNER, JERROLD R.) Jul 1, 2004 - Jun 30, 2023
    NIH
    Perijunctional myosin light chain kinase recruitment: A novel, non-enzymatic target for therapeutic intestinal barrier restoration
    Role: Principal Investigator
  5. R01DK061931 (TURNER, JERROLD R.) Sep 29, 2001 - Jun 30, 2024
    NIH
    MECHANISTIC UNDERSTANDING OF PROTEIN INTERACTIONS AT THE TIGHT JUNCTION: STRUCTURAL REGULATION OF CANONICAL AND NONCANONICAL FUNCTIONS
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Shashikanth N, Rizzo HE, Pongkorpsakol P, Heneghan JF, Turner JR. Correction: Electrophysiologic Analysis of Tight Junction Size and Charge Selectivity. Curr Protoc. 2021 Sep; 1(9):e259. PMID: 34495581.
    Citations:    
  2. Kuo WT, Zuo L, Odenwald MA, Madha S, Singh G, Gurniak CB, Abraham C, Turner JR. The Tight Junction Protein ZO-1 Is Dispensable for Barrier Function but Critical for Effective Mucosal Repair. Gastroenterology. 2021 Aug 31. PMID: 34478742.
    Citations:    Fields:    
  3. Huang YJ, Lee TC, Pai YC, Lin BR, Turner JR, Yu LC. A novel tumor suppressor role of myosin light chain kinase splice variants through downregulation of the TEAD4/CD44 axis. Carcinogenesis. 2021 Jul 16; 42(7):961-974. PMID: 34000008.
    Citations:    Fields:    
  4. Shashikanth N, Rizzo HE, Pongkorpsakol P, Heneghan JF, Turner JR. Electrophysiologic Analysis of Tight Junction Size and Charge Selectivity. Curr Protoc. 2021 Jun; 1(6):e143. PMID: 34106526.
    Citations: 1     Translation:Cells
  5. Abtahi S, Gliksman NR, Heneghan JF, Nilsen SP, Muhlich JL, Copeland J, Rozbicki E, Allan C, Dudeja PK, Turner JR. A Simple Method for Creating a High-Content Microscope for Imaging Multiplexed Tissue Microarrays. Curr Protoc. 2021 Apr; 1(4):e68. PMID: 33822482.
    Citations:    
  6. Yvellez OV, Rai V, Sossenheimer PH, Hart J, Turner JR, Weber C, El Jurdi K, Rubin DT. Cumulative Histologic Inflammation Predicts Colorectal Neoplasia in Ulcerative Colitis: A Validation Study. Inflamm Bowel Dis. 2021 01 19; 27(2):203-206. PMID: 32152624.
    Citations:    Fields:    
  7. Ye S, Matthan NR, Lamon-Fava S, Solano-Aguilar G, Turner JR, Walker ME, Chai Z, Lakshman S, Chen C, Dawson H, Urban JF, Lichtenstein AH. Colon transcriptome is modified by a dietary pattern/atorvastatin interaction in the Ossabaw pig. J Nutr Biochem. 2021 04; 90:108570. PMID: 33429036.
    Citations:    Fields:    Translation:HumansAnimalsCells
  8. Chanez-Paredes SD, Abtahi S, Kuo WT, Turner JR. Differentiating Between Tight Junction-Dependent and Tight Junction-Independent Intestinal Barrier Loss In Vivo. Methods Mol Biol. 2021; 2367:249-271. PMID: 33830456.
    Citations:    Fields:    
  9. Ye S, Matthan NR, Lamon-Fava S, Aguilar GS, Turner JR, Walker ME, Chai Z, Lakshman S, Urban JF, Lichtenstein AH. Western and heart healthy dietary patterns differentially affect the expression of genes associated with lipid metabolism, interferon signaling and inflammation in the jejunum of Ossabaw pigs. J Nutr Biochem. 2021 04; 90:108577. PMID: 33388349.
    Citations:    Fields:    Translation:HumansAnimals
  10. Labarta-Bajo L, Nilsen SP, Humphrey G, Schwartz T, Sanders K, Swafford A, Knight R, Turner JR, Zúñiga EI. Type I IFNs and CD8 T cells increase intestinal barrier permeability after chronic viral infection. J Exp Med. 2020 12 07; 217(12). PMID: 32880630.
    Citations: 3     Fields:    Translation:AnimalsCells
  11. Pongkorpsakol P, Turner JR, Zuo L. Culture of Intestinal Epithelial Cell Monolayers and Their Use in Multiplex Macromolecular Permeability Assays for In Vitro Analysis of Tight Junction Size Selectivity. Curr Protoc Immunol. 2020 12; 131(1):e112. PMID: 33175441.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  12. Caron TJ, Scott KE, Sinha N, Muthupalani S, Baqai M, Ang LH, Li Y, Turner JR, Fox JG, Hagen SJ. Claudin-18 Loss Alters Transcellular Chloride Flux but not Tight Junction Ion Selectivity in Gastric Epithelial Cells. Cell Mol Gastroenterol Hepatol. 2021; 11(3):783-801. PMID: 33069918.
    Citations: 1     Fields:    
  13. Christensen B, Hanauer SB, Gibson PR, Turner JR, Hart J, Rubin DT. Segmental Histological Normalisation Occurs in Ulcerative Colitis but Does Not Improve Clinical Outcomes. J Crohns Colitis. 2020 Oct 05; 14(10):1345-1353. PMID: 32267926.
    Citations:    Fields:    Translation:Humans
  14. Raju P, Shashikanth N, Tsai PY, Pongkorpsakol P, Chanez-Paredes S, Steinhagen PR, Kuo WT, Singh G, Tsukita S, Turner JR. Inactivation of paracellular cation-selective claudin-2 channels attenuates immune-mediated experimental colitis in mice. J Clin Invest. 2020 10 01; 130(10):5197-5208. PMID: 32516134.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  15. Cao F, Zhu L, Zhang J, Pongkorpsakol P, Kuo WT, Turner JR, Zhou Q, Wang Y, Chen F, Liu Y, Zuo L. Myosin light chain kinase is a potential target for hypopharyngeal cancer treatment. Biomed Pharmacother. 2020 Nov; 131:110665. PMID: 32920510.
    Citations: 1     Fields:    Translation:HumansAnimals
  16. Stevens TW, Gecse K, Turner JR, de Hertogh G, Rubin DT, D'Haens GR. Diagnostic Accuracy of Fecal Calprotectin Concentration in Evaluating Therapeutic Outcomes of Patients With Ulcerative Colitis. Clin Gastroenterol Hepatol. 2020 Aug 13. PMID: 32801008.
    Citations: 2     Fields:    
  17. Pai YC, Weng LT, Wei SC, Wu LL, Shih DQ, Targan SR, Turner JR, Yu LC. Gut microbial transcytosis induced by tumor necrosis factor-like 1A-dependent activation of a myosin light chain kinase splice variant contributes to IBD. J Crohns Colitis. 2020 Aug 08. PMID: 32770194.
    Citations: 3     Fields:    
  18. Abtahi S, Turner JR. Exploiting Alternative Brush Border Trafficking Routes to Treat Microvillous Inclusion Disease. Gastroenterology. 2020 10; 159(4):1233-1235. PMID: 32777279.
    Citations:    Fields:    Translation:AnimalsCells
  19. Kang JW, Yan J, Ranjan K, Zhang X, Turner JR, Abraham C. Myeloid Cell Expression of LACC1 Is Required for Bacterial Clearance and Control of Intestinal Inflammation. Gastroenterology. 2020 09; 159(3):1051-1067. PMID: 32693188.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  20. Donowitz M, Turner JR, Verkman AS, Zachos NC. Current and potential future applications of human stem cell models in drug development. J Clin Invest. 2020 07 01; 130(7):3342-3344. PMID: 32452833.
    Citations: 2     Fields:    Translation:HumansCells
  21. Yan J, Pandey SP, Barnes BJ, Turner JR, Abraham C. T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal Inflammation. Cell Rep. 2020 06 30; 31(13):107820. PMID: 32610123.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  22. Rutlin M, Rastelli D, Kuo WT, Estep JA, Louis A, Riccomagno MM, Turner JR, Rao M. The Villin1 Gene Promoter Drives Cre Recombinase Expression in Extraintestinal Tissues. Cell Mol Gastroenterol Hepatol. 2020; 10(4):864-867.e5. PMID: 32464312.
    Citations: 1     Fields:    
  23. Wu S, Yang J, Turner JR. Segmental Polyposis. Gastroenterology. 2020 12; 159(6):e1-e2. PMID: 32325087.
    Citations:    Fields:    Translation:Humans
  24. Zuo L, Kuo WT, Turner JR. Tight Junctions as Targets and Effectors of Mucosal Immune Homeostasis. Cell Mol Gastroenterol Hepatol. 2020; 10(2):327-340. PMID: 32304780.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  25. Inczefi O, Bacquié V, Olier-Pierre M, Rincel M, Ringot-Destrez B, Ellero-Simatos S, Eutamène H, Bétoulières C, Thomas J, Lainé J, Gros L, Lévêque M, Leonard R, Harkat C, Robbe-Masselot C, Róka R, Mercier-Bonin M, Theodorou V, Darnaudéry M, Turner JR, Ferrier L. Targeted Intestinal Tight Junction Hyperpermeability Alters the Microbiome, Behavior, and Visceromotor Responses. Cell Mol Gastroenterol Hepatol. 2020; 10(1):206-208.e3. PMID: 32147490.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  26. Xie S, Jiang L, Wang M, Sun W, Yu S, Turner JR, Yu Q. Cadmium ingestion exacerbates Salmonella infection, with a loss of goblet cells through activation of Notch signaling pathways by ROS in the intestine. J Hazard Mater. 2020 06 05; 391:122262. PMID: 32062544.
    Citations:    Fields:    Translation:AnimalsCells
  27. He WQ, Wang J, Sheng JY, Zha JM, Graham WV, Turner JR. Contributions of Myosin Light Chain Kinase to Regulation of Epithelial Paracellular Permeability and Mucosal Homeostasis. Int J Mol Sci. 2020 Feb 03; 21(3). PMID: 32028590.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  28. Li HS, Xu SF, Sheng JY, Jiang ZH, Wang J, Ding N, Wang T, Odenwald MA, Turner JR, He WQ, Xu H, Zha JM. Quantification of Proliferative and Dead Cells in Enteroids. J Vis Exp. 2020 01 31; (155). PMID: 32065148.
    Citations:    Fields:    Translation:Animals
  29. Christensen B, Erlich J, Gibson PR, Turner JR, Hart J, Rubin DT. Histologic Healing Is More Strongly Associated with Clinical Outcomes in Ileal Crohn's Disease than Endoscopic Healing. Clin Gastroenterol Hepatol. 2020 10; 18(11):2518-2525.e1. PMID: 31812654.
    Citations: 7     Fields:    Translation:Humans
  30. Ong MLDM, Yeruva S, Sailer A, Nilsen SP, Turner JR. Differential regulation of claudin-2 and claudin-15 expression in children and adults with malabsorptive disease. Lab Invest. 2020 03; 100(3):483-490. PMID: 31605016.
    Citations: 5     Fields:    Translation:Humans
  31. Kuo WT, Shen L, Zuo L, Shashikanth N, Ong MLDM, Wu L, Zha J, Edelblum KL, Wang Y, Wang Y, Nilsen SP, Turner JR. Inflammation-induced Occludin Downregulation Limits Epithelial Apoptosis by Suppressing Caspase-3 Expression. Gastroenterology. 2019 11; 157(5):1323-1337. PMID: 31401143.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  32. Cil O, Anderson MO, Yen R, Kelleher B, Huynh TL, Seo Y, Nilsen SP, Turner JR, Verkman AS. Slowed gastric emptying and improved oral glucose tolerance produced by a nanomolar-potency inhibitor of calcium-activated chloride channel TMEM16A. FASEB J. 2019 10; 33(10):11247-11257. PMID: 31299174.
    Citations: 3     Fields:    Translation:HumansAnimals
  33. Pandey SP, Yan J, Turner JR, Abraham C. Correction to: Reducing IRF5 expression attenuates colitis in mice, but impairs the clearance of intestinal pathogens. Mucosal Immunol. 2019 Jul; 12(4):1065. PMID: 31182816.
    Citations:    Fields:    
  34. Turner JR. On the Genesis of CMGH. Cell Mol Gastroenterol Hepatol. 2019; 8(1):143-144. PMID: 31082350.
    Citations:    Fields:    
  35. Pandey SP, Yan J, Turner JR, Abraham C. Reducing IRF5 expression attenuates colitis in mice, but impairs the clearance of intestinal pathogens. Mucosal Immunol. 2019 07; 12(4):874-887. PMID: 31053739.
    Citations: 4     Fields:    Translation:AnimalsCells
  36. Turner JR. Rigor, Reproducibility, and Responsibility: A Quantum of Solace. Cell Mol Gastroenterol Hepatol. 2019; 7(4):869-871. PMID: 30978310.
    Citations:    Fields:    
  37. Graham WV, He W, Marchiando AM, Zha J, Singh G, Li HS, Biswas A, Ong MLDM, Jiang ZH, Choi W, Zuccola H, Wang Y, Griffith J, Wu J, Rosenberg HJ, Wang Y, Snapper SB, Ostrov D, Meredith SC, Miller LW, Turner JR. Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis. Nat Med. 2019 04; 25(4):690-700. PMID: 30936544.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  38. Nalle SC, Zuo L, Ong MLDM, Singh G, Worthylake AM, Choi W, Manresa MC, Southworth AP, Edelblum KL, Baker GJ, Joseph NE, Savage PA, Turner JR. Graft-versus-host disease propagation depends on increased intestinal epithelial tight junction permeability. J Clin Invest. 2019 02 01; 129(2):902-914. PMID: 30667372.
    Citations: 15     Fields:    Translation:AnimalsCells
  39. Tse CM, Yin J, Singh V, Sarker R, Lin R, Verkman AS, Turner JR, Donowitz M. cAMP Stimulates SLC26A3 Activity in Human Colon by a CFTR-Dependent Mechanism That Does Not Require CFTR Activity. Cell Mol Gastroenterol Hepatol. 2019; 7(3):641-653. PMID: 30659943.
    Citations: 8     Fields:    Translation:HumansCells
  40. Odenwald MA, Choi W, Kuo WT, Singh G, Sailer A, Wang Y, Shen L, Fanning AS, Turner JR. The scaffolding protein ZO-1 coordinates actomyosin and epithelial apical specializations in vitro and in vivo. J Biol Chem. 2018 11 09; 293(45):17317-17335. PMID: 30242130.
    Citations: 20     Fields:    Translation:AnimalsCells
  41. Zha JM, Li HS, Lin Q, Kuo WT, Jiang ZH, Tsai PY, Ding N, Wu J, Xu SF, Wang YT, Pan J, Zhou XM, Chen K, Tao M, Odenwald MA, Tamura A, Tsukita S, Turner JR, He WQ. Interleukin 22 Expands Transit-Amplifying Cells While Depleting Lgr5+ Stem Cells via Inhibition of Wnt and Notch Signaling. Cell Mol Gastroenterol Hepatol. 2019; 7(2):255-274. PMID: 30686779.
    Citations: 20     Fields:    Translation:AnimalsCells
  42. Almansour K, Taverner A, Turner JR, Eggleston IM, Mrsny RJ. An intestinal paracellular pathway biased toward positively-charged macromolecules. J Control Release. 2018 10 28; 288:111-125. PMID: 30194947.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  43. Aihara E, Medina-Candelaria NM, Hanyu H, Matthis AL, Engevik KA, Gurniak CB, Witke W, Turner JR, Zhang T, Montrose MH. Cell injury triggers actin polymerization to initiate epithelial restitution. J Cell Sci. 2018 08 20; 131(16). PMID: 30072444.
    Citations: 6     Fields:    Translation:AnimalsCells
  44. Zukauskas A, Mrsny RJ, Cortés Barrantes P, Turner JR, Leong JM, McCormick BA. Transporters MRP1 and MRP2 Regulate Opposing Inflammatory Signals To Control Transepithelial Neutrophil Migration during Streptococcus pneumoniae Lung Infection. mSphere. 2018 07 05; 3(4). PMID: 29976647.
    Citations:    Fields:    Translation:HumansAnimalsCells
  45. Hu MD, Ethridge AD, Lipstein R, Kumar S, Wang Y, Jabri B, Turner JR, Edelblum KL. Epithelial IL-15 Is a Critical Regulator of ?d Intraepithelial Lymphocyte Motility within the Intestinal Mucosa. J Immunol. 2018 07 15; 201(2):747-756. PMID: 29884699.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  46. Drolia R, Tenguria S, Durkes AC, Turner JR, Bhunia AK. Listeria Adhesion Protein Induces Intestinal Epithelial Barrier Dysfunction for Bacterial Translocation. Cell Host Microbe. 2018 04 11; 23(4):470-484.e7. PMID: 29606495.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  47. Syed S, Yeruva S, Herrmann J, Sailer A, Sadiq K, Iqbal N, Kabir F, Ahmed K, Qureshi S, Moore SR, Turner J, Ali SA. Environmental Enteropathy in Undernourished Pakistani Children: Clinical and Histomorphometric Analyses. Am J Trop Med Hyg. 2018 06; 98(6):1577-1584. PMID: 29611507.
    Citations: 6     Fields:    Translation:HumansCells
  48. Hoffman JM, Sideri A, Ruiz JJ, Stavrakis D, Shih DQ, Turner JR, Pothoulakis C, Karagiannides I. Mesenteric Adipose-derived Stromal Cells From Crohn's Disease Patients Induce Protective Effects in Colonic Epithelial Cells and Mice With Colitis. Cell Mol Gastroenterol Hepatol. 2018; 6(1):1-16. PMID: 29928668.
    Citations: 3     Fields:    
  49. Turner JR, Goldenring JR, Rescigno M, Wells RG. State of the Journal: CMGH's Progress, Prospects, and Impact Factor. Gastroenterology. 2018 Feb; 154(3):460-461. PMID: 29433893.
    Citations:    Fields:    Translation:Humans
  50. Krugliak Cleveland N, Huo D, Sadiq F, Sofia MA, Marks J, Cohen RD, Hanauer SB, Turner J, Hart J, Rubin DT. Assessment of peri-polyp biopsy specimens of flat mucosa in patients with inflammatory bowel disease. Gastrointest Endosc. 2018 May; 87(5):1304-1309. PMID: 29307473.
    Citations: 3     Fields:    Translation:Humans
  51. Buckley A, Turner JR. Cell Biology of Tight Junction Barrier Regulation and Mucosal Disease. Cold Spring Harb Perspect Biol. 2018 01 02; 10(1). PMID: 28507021.
    Citations: 81     Fields:    Translation:HumansAnimalsCells
  52. Sallis BF, Erkert L, Moñino-Romero S, Acar U, Wu R, Konnikova L, Lexmond WS, Hamilton MJ, Dunn WA, Szepfalusi Z, Vanderhoof JA, Snapper SB, Turner JR, Goldsmith JD, Spencer LA, Nurko S, Fiebiger E. An algorithm for the classification of mRNA patterns in eosinophilic esophagitis: Integration of machine learning. J Allergy Clin Immunol. 2018 04; 141(4):1354-1364.e9. PMID: 29273402.
    Citations: 2     Fields:    Translation:Humans
  53. Turner JR, Goldenring JR, Rescigno M, Wells RG. State of the Journal: CMGH's Progress, Prospects, and Impact Factor. Cell Mol Gastroenterol Hepatol. 2018; 5(2):157-158. PMID: 29693041.
    Citations:    Fields:    
  54. Garber JJ, Mallick EM, Scanlon KM, Turner JR, Donnenberg MS, Leong JM, Snapper SB. Attaching-and-Effacing Pathogens Exploit Junction Regulatory Activities of N-WASP and SNX9 to Disrupt the Intestinal Barrier. Cell Mol Gastroenterol Hepatol. 2018 Mar; 5(3):273-288. PMID: 29675452.
    Citations: 11     Fields:    
  55. Shashikanth N, Yeruva S, Ong MLDM, Odenwald MA, Pavlyuk R, Turner JR. Epithelial Organization: The Gut and Beyond. Compr Physiol. 2017 Sep 12; 7(4):1497-1518. PMID: 28915334.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  56. Amadi B, Besa E, Zyambo K, Kaonga P, Louis-Auguste J, Chandwe K, Tarr PI, Denno DM, Nataro JP, Faubion W, Sailer A, Yeruva S, Brantner T, Murray J, Prendergast AJ, Turner JR, Kelly P. Impaired Barrier Function and Autoantibody Generation in Malnutrition Enteropathy in Zambia. EBioMedicine. 2017 Aug; 22:191-199. PMID: 28750860.
    Citations: 23     Fields:    Translation:Humans
  57. Ma Y, Yue J, Zhang Y, Shi C, Odenwald M, Liang WG, Wei Q, Goel A, Gou X, Zhang J, Chen SY, Tang WJ, Turner JR, Yang F, Liang H, Qin H, Wu X. Erratum: ACF7 regulates inflammatory colitis and intestinal wound response by orchestrating tight junction dynamics. Nat Commun. 2017 07 11; 8:16121. PMID: 28695897.
    Citations: 1     Fields:    
  58. Tsai PY, Zhang B, He WQ, Zha JM, Odenwald MA, Singh G, Tamura A, Shen L, Sailer A, Yeruva S, Kuo WT, Fu YX, Tsukita S, Turner JR. IL-22 Upregulates Epithelial Claudin-2 to Drive Diarrhea and Enteric Pathogen Clearance. . 2017 Jun 14; 21(6):671-681.e4. PMID: 28618266.
    Citations: 46     Translation:AnimalsCells
  59. Weber CR, Turner JR. Dynamic modeling of the tight junction pore pathway. Ann N Y Acad Sci. 2017 06; 1397(1):209-218. PMID: 28605031.
    Citations: 7     Fields:    Translation:AnimalsCells
  60. Edelblum KL, Sharon G, Singh G, Odenwald MA, Sailer A, Cao S, Ravens S, Thomsen I, El Bissati K, McLeod R, Dong C, Gurbuxani S, Prinz I, Mazmanian SK, Turner JR. The Microbiome Activates CD4 T-cell-mediated Immunity to Compensate for Increased Intestinal Permeability. Cell Mol Gastroenterol Hepatol. 2017 Sep; 4(2):285-297. PMID: 28795125.
    Citations: 19     Fields:    
  61. Ma Y, Yue J, Zhang Y, Shi C, Odenwald M, Liang WG, Wei Q, Goel A, Gou X, Zhang J, Chen SY, Tang WJ, Turner JR, Yang F, Liang H, Qin H, Wu X. ACF7 regulates inflammatory colitis and intestinal wound response by orchestrating tight junction dynamics. Nat Commun. 2017 05 25; 8:15375. PMID: 28541346.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  62. Wang LC, Yu Q, Edwards V, Lin B, Qiu J, Turner JR, Stein DC, Song W. Neisseria gonorrhoeae infects the human endocervix by activating non-muscle myosin II-mediated epithelial exfoliation. PLoS Pathog. 2017 Apr; 13(4):e1006269. PMID: 28406994.
    Citations: 13     Fields:    Translation:HumansCells
  63. Choi W, Yeruva S, Turner JR. Contributions of intestinal epithelial barriers to health and disease. Exp Cell Res. 2017 09 01; 358(1):71-77. PMID: 28342899.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  64. Peters SA, Edogawa S, Sundt WJ, Dyer RB, Dalenberg DA, Mazzone A, Singh RJ, Moses N, Smyrk TC, Weber C, Linden DR, MacNaughton WK, Turner JR, Camilleri M, Katzka DA, Farrugia G, Grover M. Constipation-Predominant Irritable Bowel Syndrome Females Have Normal Colonic Barrier and Secretory Function. Am J Gastroenterol. 2017 Jun; 112(6):913-923. PMID: 28323272.
    Citations: 14     Fields:    Translation:HumansCells
  65. Christensen B, Hanauer SB, Erlich J, Kassim O, Gibson PR, Turner JR, Hart J, Rubin DT. Histologic Normalization Occurs in Ulcerative Colitis and Is Associated With Improved Clinical Outcomes. Clin Gastroenterol Hepatol. 2017 Oct; 15(10):1557-1564.e1. PMID: 28238954.
    Citations: 31     Fields:    Translation:Humans
  66. Turner JR. The CMGH Awards. Cell Mol Gastroenterol Hepatol. 2017 Mar; 3(2):129-130. PMID: 28275676.
    Citations:    Fields:    
  67. France MM, Turner JR. The mucosal barrier at a glance. J Cell Sci. 2017 01 15; 130(2):307-314. PMID: 28062847.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  68. Blackwood BP, Wood DR, Yuan C, Nicolas J, De Plaen IG, Farrow KN, Chou P, Turner JR, Hunter CJ. A Role for cAMP and Protein Kinase A in Experimental Necrotizing Enterocolitis. Am J Pathol. 2017 Feb; 187(2):401-417. PMID: 27939131.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  69. Turner JR. A Picture Is Worth a Thousand Words. Cell Mol Gastroenterol Hepatol. 2017 Jan; 3(1):1. PMID: 28174750.
    Citations:    Fields:    
  70. Wu RL, Vazquez-Roque MI, Carlson P, Burton D, Grover M, Camilleri M, Turner JR. Gluten-induced symptoms in diarrhea-predominant irritable bowel syndrome are associated with increased myosin light chain kinase activity and claudin-15 expression. Lab Invest. 2017 01; 97(1):14-23. PMID: 27869798.
    Citations: 17     Fields:    Translation:HumansCells
  71. Odenwald MA, Turner JR. The intestinal epithelial barrier: a therapeutic target? Nat Rev Gastroenterol Hepatol. 2017 Jan; 14(1):9-21. PMID: 27848962.
    Citations: 175     Fields:    Translation:HumansAnimalsCells
  72. Odenwald MA, Choi W, Buckley A, Shashikanth N, Joseph NE, Wang Y, Warren MH, Buschmann MM, Pavlyuk R, Hildebrand J, Margolis B, Fanning AS, Turner JR. ZO-1 interactions with F-actin and occludin direct epithelial polarization and single lumen specification in 3D culture. J Cell Sci. 2017 01 01; 130(1):243-259. PMID: 27802160.
    Citations: 42     Fields:    Translation:HumansCells
  73. Turner JR. PubMed, PubMed Central, and Impact Factor. Cell Mol Gastroenterol Hepatol. 2016 Sep; 2(5):537. PMID: 28174731.
    Citations:    Fields:    
  74. Ronaghan NJ, Shang J, Iablokov V, Zaheer R, Colarusso P, Dion S, Désilets A, Leduc R, Turner JR, MacNaughton WK. The serine protease-mediated increase in intestinal epithelial barrier function is dependent on occludin and requires an intact tight junction. Am J Physiol Gastrointest Liver Physiol. 2016 09 01; 311(3):G466-79. PMID: 27492333.
    Citations: 10     Fields:    Translation:AnimalsCells
  75. Bartelt LA, Bolick DT, Kolling GL, Roche JK, Zaenker EI, Lara AM, Noronha FJ, Cowardin CA, Moore JH, Turner JR, Warren CA, Buck GA, Guerrant RL. Cryptosporidium Priming Is More Effective than Vaccine for Protection against Cryptosporidiosis in a Murine Protein Malnutrition Model. PLoS Negl Trop Dis. 2016 07; 10(7):e0004820. PMID: 27467505.
    Citations: 12     Fields:    Translation:Animals
  76. Omary MB, Cohen DE, El-Omar EM, Jalan R, Low MJ, Nathanson MH, Peek RM, Turner JR. Not all mice are the same: Standardization of animal research data presentation. Hepatology. 2016 06; 63(6):1752-4. PMID: 27205897.
    Citations: 4     Fields:    Translation:Animals
  77. Omary MB, Cohen DE, El-Omar E, Jalan R, Low M, Nathanson M, Peek R, Turner J. Not All Mice Are the Same: Standardization of Animal Research Data Presentation. Gut. 2016 06; 65(6):894-5. PMID: 27197119.
    Citations: 1     Fields:    Translation:Animals
  78. Omary MB, Cohen DE, El-Omar EM, Jalan R, Low MJ, Nathanson MH, Peek RM, Turner JR. Not All Mice Are the Same: Standardization of Animal Research Data Presentation. Cell Mol Gastroenterol Hepatol. 2016 Jul; 2(4):391-393. PMID: 28174724.
    Citations: 1     Fields:    
  79. Choi VM, Herrou J, Hecht AL, Teoh WP, Turner JR, Crosson S, Bubeck Wardenburg J. Activation of Bacteroides fragilis toxin by a novel bacterial protease contributes to anaerobic sepsis in mice. Nat Med. 2016 05; 22(5):563-7. PMID: 27089515.
    Citations: 29     Fields:    Translation:AnimalsCells
  80. Omary MB, Cohen DE, El-Omar EM, Jalan R, Low MJ, Nathanson MH, Peek RM, Turner JR. Not All Mice Are the Same: Standardization of Animal Research Data Presentation. Gastroenterology. 2016 06; 150(7):1503-1504. PMID: 27063865.
    Citations: 3     Fields:    Translation:HumansAnimals
  81. Weber MA, Turner JR. Ambulatory Blood Pressure Monitoring: New Directions and Uncertainties Arise From the U.S. Preventive Services Task Force Recommendation on the Diagnosis of Hypertension. J Clin Hypertens (Greenwich). 2016 Mar; 18(3):172-4. PMID: 26899617.
    Citations: 2     Fields:    Translation:Humans
  82. Mir H, Meena AS, Chaudhry KK, Shukla PK, Gangwar R, Manda B, Padala MK, Shen L, Turner JR, Dietrich P, Dragatsis I, Rao R. Occludin deficiency promotes ethanol-induced disruption of colonic epithelial junctions, gut barrier dysfunction and liver damage in mice. Biochim Biophys Acta. 2016 Apr; 1860(4):765-74. PMID: 26721332.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  83. Herrmann JR, Turner JR. Beyond Ussing's chambers: contemporary thoughts on integration of transepithelial transport. . 2016 Mar 15; 310(6):C423-31. PMID: 26702131.
    Citations: 13     Translation:HumansAnimalsCells
  84. Turner JR. Looking Back; Looking Forward! Cell Mol Gastroenterol Hepatol. 2016 Jan; 2(1):1. PMID: 28174698.
    Citations:    Fields:    
  85. Weber CR, Liang GH, Wang Y, Das S, Shen L, Yu AS, Nelson DJ, Turner JR. Claudin-2-dependent paracellular channels are dynamically gated. Elife. 2015 Nov 14; 4:e09906. PMID: 26568313.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  86. Turner JR. CMGH Is Growing! Cell Mol Gastroenterol Hepatol. 2015 Sep; 1(5):453. PMID: 28210692.
    Citations:    Fields:    
  87. Sideri A, Bakirtzi K, Shih DQ, Koon HW, Fleshner P, Arsenescu R, Arsenescu V, Turner JR, Karagiannides I, Pothoulakis C. Substance P mediates pro-inflammatory cytokine release form mesenteric adipocytes in Inflammatory Bowel Disease patients. Cell Mol Gastroenterol Hepatol. 2015 Jul 01; 1(4):420-432. PMID: 26543894.
    Citations: 14     Fields:    
  88. Powers ME, Becker RE, Sailer A, Turner JR, Bubeck Wardenburg J. Synergistic Action of Staphylococcus aureus a-Toxin on Platelets and Myeloid Lineage Cells Contributes to Lethal Sepsis. . 2015 Jun 10; 17(6):775-87. PMID: 26067604.
    Citations: 42     Translation:HumansAnimalsCells
  89. Lingaraju A, Long TM, Wang Y, Austin JR, Turner JR. Conceptual barriers to understanding physical barriers. Semin Cell Dev Biol. 2015 Jun; 42:13-21. PMID: 26003050.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  90. Setty M, Discepolo V, Abadie V, Kamhawi S, Mayassi T, Kent A, Ciszewski C, Maglio M, Kistner E, Bhagat G, Semrad C, Kupfer SS, Green PH, Guandalini S, Troncone R, Murray JA, Turner JR, Jabri B. Distinct and Synergistic Contributions of Epithelial Stress and Adaptive Immunity to Functions of Intraepithelial Killer Cells and Active Celiac Disease. Gastroenterology. 2015 Sep; 149(3):681-91.e10. PMID: 26001928.
    Citations: 36     Fields:    Translation:HumansCells
  91. Nalle SC, Turner JR. Intestinal barrier loss as a critical pathogenic link between inflammatory bowel disease and graft-versus-host disease. Mucosal Immunol. 2015 Jul; 8(4):720-30. PMID: 25943273.
    Citations: 36     Fields:    Translation:HumansAnimals
  92. Tripathi AK, Haldar S, Qian J, Beserra A, Suda S, Singh A, Hopfer U, Chen SG, Garrick MD, Turner JR, Knutson MD, Singh N. Prion protein functions as a ferrireductase partner for ZIP14 and DMT1. Free Radic Biol Med. 2015 Jul; 84:322-330. PMID: 25862412.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  93. Edelblum KL, Singh G, Odenwald MA, Lingaraju A, El Bissati K, McLeod R, Sperling AI, Turner JR. ?d Intraepithelial Lymphocyte Migration Limits Transepithelial Pathogen Invasion and Systemic Disease in Mice. Gastroenterology. 2015 Jun; 148(7):1417-26. PMID: 25747597.
    Citations: 39     Fields:    Translation:AnimalsCells
  94. Luther J, Garber JJ, Khalili H, Dave M, Bale SS, Jindal R, Motola DL, Luther S, Bohr S, Jeoung SW, Deshpande V, Singh G, Turner JR, Yarmush ML, Chung RT, Patel SJ. Hepatic Injury in Nonalcoholic Steatohepatitis Contributes to Altered Intestinal Permeability. Cell Mol Gastroenterol Hepatol. 2015 Mar; 1(2):222-232. PMID: 26405687.
    Citations: 69     Fields:    
  95. Dubnansky EC, Lowe CB, Petrovic TK, Brounstein LM, El-Serag HB, Turner JR, Bishr Omary M. Why send your paper to Gastroenterology: global outreach and partnerships with sister journals, CGH and CMGH, among a menu of offerings. Gastroenterology. 2015 Apr; 148(4):673-8. PMID: 25705033.
    Citations:    Fields:    Translation:Humans
  96. Pan J, Zhang L, Odenwald MA, Shen L, Turner JR, Bergelson JM. Expression of human decay-accelerating factor on intestinal epithelium of transgenic mice does not facilitate infection by the enteral route. J Virol. 2015 Apr; 89(8):4311-8. PMID: 25653430.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  97. Turner JR. A Journey of a Thousand Miles Begins With a Single Step, and Then Another . . . Cell Mol Gastroenterol Hepatol. 2015 Mar; 1(2):121-122. PMID: 28210668.
    Citations: 1     Fields:    
  98. Chen P, Stärkel P, Turner JR, Ho SB, Schnabl B. Dysbiosis-induced intestinal inflammation activates tumor necrosis factor receptor I and mediates alcoholic liver disease in mice. Hepatology. 2015 Mar; 61(3):883-94. PMID: 25251280.
    Citations: 100     Fields:    Translation:Animals
  99. Sideri A, Stavrakis D, Bowe C, Shih DQ, Fleshner P, Arsenescu V, Arsenescu R, Turner JR, Pothoulakis C, Karagiannides I. Effects of obesity on severity of colitis and cytokine expression in mouse mesenteric fat. Potential role of adiponectin receptor 1. Am J Physiol Gastrointest Liver Physiol. 2015 Apr 01; 308(7):G591-604. PMID: 25591865.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  100. Turner JR, Goldenring JR, Wells RG, Brounstein LM. CMGH: The Revolution Starts Now. Cell Mol Gastroenterol Hepatol. 2015 Jan; 1(1):1. PMID: 28210665.
    Citations:    Fields:    
  101. Haldar S, Tripathi A, Qian J, Beserra A, Suda S, McElwee M, Turner J, Hopfer U, Singh N. Prion protein promotes kidney iron uptake via its ferrireductase activity. J Biol Chem. 2015 Feb 27; 290(9):5512-22. PMID: 25572394.
    Citations: 15     Fields:    Translation:AnimalsCells
  102. Turner JR, Buschmann MM, Romero-Calvo I, Sailer A, Shen L. The role of molecular remodeling in differential regulation of tight junction permeability. Semin Cell Dev Biol. 2014 Dec; 36:204-12. PMID: 25263012.
    Citations: 61     Fields:    Translation:HumansCells
  103. Konda VJ, Koons A, Siddiqui UD, Xiao SY, Turner JR, Waxman I. Optical biopsy approaches in Barrett's esophagus with next-generation optical coherence tomography. Gastrointest Endosc. 2014 Sep; 80(3):516-7. PMID: 25127947.
    Citations: 5     Fields:    Translation:Humans
  104. Chen MM, Zahs A, Brown MM, Ramirez L, Turner JR, Choudhry MA, Kovacs EJ. An alteration of the gut-liver axis drives pulmonary inflammation after intoxication and burn injury in mice. Am J Physiol Gastrointest Liver Physiol. 2014 Oct 01; 307(7):G711-8. PMID: 25104501.
    Citations: 16     Fields:    Translation:AnimalsCells
  105. Yu LC, Shih YA, Wu LL, Lin YD, Kuo WT, Peng WH, Lu KS, Wei SC, Turner JR, Ni YH. Enteric dysbiosis promotes antibiotic-resistant bacterial infection: systemic dissemination of resistant and commensal bacteria through epithelial transcytosis. Am J Physiol Gastrointest Liver Physiol. 2014 Oct 15; 307(8):G824-35. PMID: 25059827.
    Citations: 24     Fields:    Translation:AnimalsCells
  106. Nalle SC, Kwak HA, Edelblum KL, Joseph NE, Singh G, Khramtsova GF, Mortenson ED, Savage PA, Turner JR. Recipient NK cell inactivation and intestinal barrier loss are required for MHC-matched graft-versus-host disease. Sci Transl Med. 2014 Jul 02; 6(243):243ra87. PMID: 24990882.
    Citations: 18     Fields:    Translation:AnimalsCells
  107. Wu LL, Peng WH, Kuo WT, Huang CY, Ni YH, Lu KS, Turner JR, Yu LC. Commensal bacterial endocytosis in epithelial cells is dependent on myosin light chain kinase-activated brush border fanning by interferon-?. Am J Pathol. 2014 Aug; 184(8):2260-74. PMID: 24911373.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  108. Ma K, Malhotra P, Soni V, Hedroug O, Annaba F, Dudeja A, Shen L, Turner JR, Khramtsova EA, Saksena S, Dudeja PK, Gill RK, Alrefai WA. Overactivation of intestinal SREBP2 in mice increases serum cholesterol. PLoS One. 2014; 9(1):e84221. PMID: 24465397.
    Citations: 15     Fields:    Translation:Animals
  109. Perera J, Liu X, Zhou Y, Joseph NE, Meng L, Turner JR, Huang H. Insufficient autoantigen presentation and failure of tolerance in a mouse model of rheumatoid arthritis. Arthritis Rheum. 2013 Nov; 65(11):2847-56. PMID: 23840022.
    Citations: 2     Fields:    Translation:AnimalsCells
  110. Buschmann MM, Shen L, Rajapakse H, Raleigh DR, Wang Y, Wang Y, Lingaraju A, Zha J, Abbott E, McAuley EM, Breskin LA, Wu L, Anderson K, Turner JR, Weber CR. Occludin OCEL-domain interactions are required for maintenance and regulation of the tight junction barrier to macromolecular flux. Mol Biol Cell. 2013 Oct; 24(19):3056-68. PMID: 23924897.
    Citations: 60     Fields:    Translation:HumansCells
  111. Turner ES, Turner JR. Expanding the Lauren classification: a new gastric cancer subtype? Gastroenterology. 2013 Sep; 145(3):505-8. PMID: 23891604.
    Citations: 7     Fields:    Translation:Humans
  112. Rubin DT, Huo D, Kinnucan JA, Sedrak MS, McCullom NE, Bunnag AP, Raun-Royer EP, Cohen RD, Hanauer SB, Hart J, Turner JR. Inflammation is an independent risk factor for colonic neoplasia in patients with ulcerative colitis: a case-control study. Clin Gastroenterol Hepatol. 2013 Dec; 11(12):1601-8.e1-4. PMID: 23872237.
    Citations: 70     Fields:    Translation:Humans
  113. Odenwald MA, Turner JR. Intestinal permeability defects: is it time to treat? Clin Gastroenterol Hepatol. 2013 Sep; 11(9):1075-83. PMID: 23851019.
    Citations: 91     Fields:    Translation:Humans
  114. Su L, Nalle SC, Shen L, Turner ES, Singh G, Breskin LA, Khramtsova EA, Khramtsova G, Tsai PY, Fu YX, Abraham C, Turner JR. TNFR2 activates MLCK-dependent tight junction dysregulation to cause apoptosis-mediated barrier loss and experimental colitis. Gastroenterology. 2013 Aug; 145(2):407-15. PMID: 23619146.
    Citations: 111     Fields:    Translation:AnimalsCells
  115. Bergmann KR, Liu SX, Tian R, Kushnir A, Turner JR, Li HL, Chou PM, Weber CR, De Plaen IG. Bifidobacteria stabilize claudins at tight junctions and prevent intestinal barrier dysfunction in mouse necrotizing enterocolitis. Am J Pathol. 2013 May; 182(5):1595-606. PMID: 23470164.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  116. Turner JR. Reply to Skarupski and Keshavarzian. Gastroenterology. 2013 Apr; 144(4):e22-3. PMID: 23499282.
    Citations:    Fields:    Translation:Humans
  117. Bouyer PG, Tang X, Weber CR, Shen L, Turner JR, Matthews JB. Capsaicin induces NKCC1 internalization and inhibits chloride secretion in colonic epithelial cells independently of TRPV1. Am J Physiol Gastrointest Liver Physiol. 2013 Jan 15; 304(2):G142-56. PMID: 23139219.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  118. Turner JR. Continuing attrition of physician-scientists (CAPS): a preventable syndrome? Gastroenterology. 2012 Sep; 143(3):511-515.e1. PMID: 22824039.
    Citations: 1     Fields:    Translation:Humans
  119. Zahs A, Bird MD, Ramirez L, Turner JR, Choudhry MA, Kovacs EJ. Inhibition of long myosin light-chain kinase activation alleviates intestinal damage after binge ethanol exposure and burn injury. Am J Physiol Gastrointest Liver Physiol. 2012 Sep 15; 303(6):G705-12. PMID: 22790598.
    Citations: 44     Fields:    Translation:Animals
  120. Cunningham KE, Turner JR. Myosin light chain kinase: pulling the strings of epithelial tight junction function. Ann N Y Acad Sci. 2012 Jul; 1258:34-42. PMID: 22731713.
    Citations: 96     Fields:    Translation:HumansAnimalsCells
  121. Hwang S, Zimmerman NP, Agle KA, Turner JR, Kumar SN, Dwinell MB. E-cadherin is critical for collective sheet migration and is regulated by the chemokine CXCL12 protein during restitution. J Biol Chem. 2012 Jun 22; 287(26):22227-40. PMID: 22549778.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  122. Edelblum KL, Shen L, Weber CR, Marchiando AM, Clay BS, Wang Y, Prinz I, Malissen B, Sperling AI, Turner JR. Dynamic migration of ?d intraepithelial lymphocytes requires occludin. Proc Natl Acad Sci U S A. 2012 May 01; 109(18):7097-102. PMID: 22511722.
    Citations: 63     Fields:    Translation:AnimalsCells
  123. Nalle SC, Turner JR. Endothelial and epithelial barriers in graft-versus-host disease. Adv Exp Med Biol. 2012; 763:105-31. PMID: 23397621.
    Citations: 6     Fields:    Translation: