Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Jerrold R Turner, M.D., Ph.D.

Other Positions


Available: 11/26/19, Expires: 08/31/21

We have defined distinct regulatory mechanisms and biophysical characteristics of two modes of intestinal barrier regulation. Both are essential for health but can also contribute to disease. This work is aimed at defining the mechanisms that disrupt and developing means of restoring the barrier in disease. The Student will have the opportunity to participate in analysis of: i) in vitro stem cell and cell line models; ii) human and mouse tissues; iii) mice with experimental disease; critical and iv) signaling events and protein interactions. The breadth and depth of each will be determined based on the students' goals and abilities in the areas of cell biology, gastroenterology, pathology, and biomedical imaging.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R56DK094954 (MILLER, LAWRENCE) Sep 21, 2012 - Aug 31, 2014
    Role: Co-Principal Investigator
  2. S10RR025643 (TURNER, JERROLD R.) Jul 16, 2010 - Jul 15, 2011
    Advanced Multi-color Confocal and FRAP-SAC Microscope
    Role: Principal Investigator
  3. P01DK067887 (HECHT, GAIL A.) Dec 1, 2005 - Jul 31, 2012
    Regulation of Intestinal Transport
    Role: Co-Principal Investigator
  4. R01DK068271 (TURNER, JERROLD R.) Jul 1, 2004 - Jun 30, 2023
    Perijunctional myosin light chain kinase recruitment: A novel, non-enzymatic target for therapeutic intestinal barrier restoration
    Role: Principal Investigator
  5. R01DK061931 (TURNER, JERROLD R.) Sep 1, 2001 - Jun 30, 2020
    ZO-1-mediated protein interactions: regulators and integrators of diverse epithelial functions in health and disease
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. He WQ, Wang J, Sheng JY, Zha JM, Graham WV, Turner JR. Contributions of Myosin Light Chain Kinase to Regulation of Epithelial Paracellular Permeability and Mucosal Homeostasis. Int J Mol Sci. 2020 Feb 03; 21(3). PMID: 32028590.
  2. Christensen B, Erlich J, Gibson PR, Turner JR, Hart J, Rubin DT. Histologic Healing is More Strongly Associated with Clinical Outcomes in Ileal Crohn's Disease than Endoscopic Healing. Clin Gastroenterol Hepatol. 2019 Dec 05. PMID: 31812654.
  3. Ong MLDM, Yeruva S, Sailer A, Nilsen SP, Turner JR. Differential regulation of claudin-2 and claudin-15 expression in children and adults with malabsorptive disease. Lab Invest. 2019 Oct 11. PMID: 31605016.
  4. Kuo WT, Shen L, Zuo L, Shashikanth N, Ong MLDM, Wu L, Zha J, Edelblum KL, Wang Y, Wang Y, Nilsen SP, Turner JR. Inflammation-induced Occludin Downregulation Limits Epithelial Apoptosis by Suppressing Caspase-3 Expression. Gastroenterology. 2019 11; 157(5):1323-1337. PMID: 31401143.
  5. Cil O, Anderson MO, Yen R, Kelleher B, Huynh TL, Seo Y, Nilsen SP, Turner JR, Verkman AS. Slowed gastric emptying and improved oral glucose tolerance produced by a nanomolar-potency inhibitor of calcium-activated chloride channel TMEM16A. FASEB J. 2019 Oct; 33(10):11247-11257. PMID: 31299174.
  6. Pandey SP, Yan J, Turner JR, Abraham C. Correction to: Reducing IRF5 expression attenuates colitis in mice, but impairs the clearance of intestinal pathogens. Mucosal Immunol. 2019 Jul; 12(4):1065. PMID: 31182816.
  7. Turner JR. On the Genesis of CMGH. Cell Mol Gastroenterol Hepatol. 2019; 8(1):143-144. PMID: 31082350.
  8. Pandey SP, Yan J, Turner JR, Abraham C. Reducing IRF5 expression attenuates colitis in mice, but impairs the clearance of intestinal pathogens. Mucosal Immunol. 2019 07; 12(4):874-887. PMID: 31053739.
  9. Turner JR. Rigor, Reproducibility, and Responsibility: A Quantum of Solace. Cell Mol Gastroenterol Hepatol. 2019; 7(4):869-871. PMID: 30978310.
  10. Graham WV, He W, Marchiando AM, Zha J, Singh G, Li HS, Biswas A, Ong MLDM, Jiang ZH, Choi W, Zuccola H, Wang Y, Griffith J, Wu J, Rosenberg HJ, Wang Y, Snapper SB, Ostrov D, Meredith SC, Miller LW, Turner JR. Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis. Nat Med. 2019 04; 25(4):690-700. PMID: 30936544.
  11. Nalle SC, Zuo L, Ong MLDM, Singh G, Worthylake AM, Choi W, Manresa MC, Southworth AP, Edelblum KL, Baker GJ, Joseph NE, Savage PA, Turner JR. Graft-versus-host disease propagation depends on increased intestinal epithelial tight junction permeability. J Clin Invest. 2019 02 01; 129(2):902-914. PMID: 30667372.
    Citations:    Fields:    
  12. Tse CM, Yin J, Singh V, Sarker R, Lin R, Verkman AS, Turner JR, Donowitz M. cAMP Stimulates SLC26A3 Activity in Human Colon by a CFTR-Dependent Mechanism That Does Not Require CFTR Activity. Cell Mol Gastroenterol Hepatol. 2019; 7(3):641-653. PMID: 30659943.
  13. Odenwald MA, Choi W, Kuo WT, Singh G, Sailer A, Wang Y, Shen L, Fanning AS, Turner JR. The scaffolding protein ZO-1 coordinates actomyosin and epithelial apical specializations in vitro and in vivo. J Biol Chem. 2018 11 09; 293(45):17317-17335. PMID: 30242130.
    Citations:    Fields:    
  14. Zha JM, Li HS, Lin Q, Kuo WT, Jiang ZH, Tsai PY, Ding N, Wu J, Xu SF, Wang YT, Pan J, Zhou XM, Chen K, Tao M, Odenwald MA, Tamura A, Tsukita S, Turner JR, He WQ. Interleukin 22 Expands Transit-Amplifying Cells While Depleting Lgr5+ Stem Cells via Inhibition of Wnt and Notch Signaling. Cell Mol Gastroenterol Hepatol. 2019; 7(2):255-274. PMID: 30686779.
  15. Almansour K, Taverner A, Turner JR, Eggleston IM, Mrsny RJ. An intestinal paracellular pathway biased toward positively-charged macromolecules. J Control Release. 2018 10 28; 288:111-125. PMID: 30194947.
  16. Aihara E, Medina-Candelaria NM, Hanyu H, Matthis AL, Engevik KA, Gurniak CB, Witke W, Turner JR, Zhang T, Montrose MH. Cell injury triggers actin polymerization to initiate epithelial restitution. J Cell Sci. 2018 08 20; 131(16). PMID: 30072444.
    Citations:    Fields:    
  17. Zukauskas A, Mrsny RJ, Cortés Barrantes P, Turner JR, Leong JM, McCormick BA. Transporters MRP1 and MRP2 Regulate Opposing Inflammatory Signals To Control Transepithelial Neutrophil Migration during Streptococcus pneumoniae Lung Infection. mSphere. 2018 07 05; 3(4). PMID: 29976647.
    Citations:    Translation:HumansAnimalsCells
  18. Hu MD, Ethridge AD, Lipstein R, Kumar S, Wang Y, Jabri B, Turner JR, Edelblum KL. Epithelial IL-15 Is a Critical Regulator of ?d Intraepithelial Lymphocyte Motility within the Intestinal Mucosa. J Immunol. 2018 07 15; 201(2):747-756. PMID: 29884699.
    Citations:    Fields:    
  19. Drolia R, Tenguria S, Durkes AC, Turner JR, Bhunia AK. Listeria Adhesion Protein Induces Intestinal Epithelial Barrier Dysfunction for Bacterial Translocation. Cell Host Microbe. 2018 04 11; 23(4):470-484.e7. PMID: 29606495.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  20. Syed S, Yeruva S, Herrmann J, Sailer A, Sadiq K, Iqbal N, Kabir F, Ahmed K, Qureshi S, Moore SR, Turner J, Ali SA. Environmental Enteropathy in Undernourished Pakistani Children: Clinical and Histomorphometric Analyses. Am J Trop Med Hyg. 2018 06; 98(6):1577-1584. PMID: 29611507.
  21. Hoffman JM, Sideri A, Ruiz JJ, Stavrakis D, Shih DQ, Turner JR, Pothoulakis C, Karagiannides I. Mesenteric Adipose-derived Stromal Cells From Crohn's Disease Patients Induce Protective Effects in Colonic Epithelial Cells and Mice With Colitis. Cell Mol Gastroenterol Hepatol. 2018; 6(1):1-16. PMID: 29928668.
  22. Turner JR, Goldenring JR, Rescigno M, Wells RG. State of the Journal: CMGH's Progress, Prospects, and Impact Factor. Gastroenterology. 2018 Feb; 154(3):460-461. PMID: 29433893.
    Citations:    Fields:    Translation:Humans
  23. Krugliak Cleveland N, Huo D, Sadiq F, Sofia MA, Marks J, Cohen RD, Hanauer SB, Turner J, Hart J, Rubin DT. Assessment of peri-polyp biopsy specimens of flat mucosa in patients with inflammatory bowel disease. Gastrointest Endosc. 2018 May; 87(5):1304-1309. PMID: 29307473.
    Citations:    Fields:    Translation:Humans
  24. Buckley A, Turner JR. Cell Biology of Tight Junction Barrier Regulation and Mucosal Disease. Cold Spring Harb Perspect Biol. 2018 01 02; 10(1). PMID: 28507021.
    Citations: 5     Fields:    
  25. Sallis BF, Erkert L, Moñino-Romero S, Acar U, Wu R, Konnikova L, Lexmond WS, Hamilton MJ, Dunn WA, Szepfalusi Z, Vanderhoof JA, Snapper SB, Turner JR, Goldsmith JD, Spencer LA, Nurko S, Fiebiger E. An algorithm for the classification of mRNA patterns in eosinophilic esophagitis: Integration of machine learning. J Allergy Clin Immunol. 2018 04; 141(4):1354-1364.e9. PMID: 29273402.
    Citations: 1     Fields:    
  26. Turner JR, Goldenring JR, Rescigno M, Wells RG. State of the Journal: CMGH's Progress, Prospects, and Impact Factor. Cell Mol Gastroenterol Hepatol. 2018; 5(2):157-158. PMID: 29693041.
  27. Garber JJ, Mallick EM, Scanlon KM, Turner JR, Donnenberg MS, Leong JM, Snapper SB. Attaching-and-Effacing Pathogens Exploit Junction Regulatory Activities of N-WASP and SNX9 to Disrupt the Intestinal Barrier. Cell Mol Gastroenterol Hepatol. 2018 Mar; 5(3):273-288. PMID: 29675452.
  28. Shashikanth N, Yeruva S, Ong MLDM, Odenwald MA, Pavlyuk R, Turner JR. Epithelial Organization: The Gut and Beyond. Compr Physiol. 2017 Sep 12; 7(4):1497-1518. PMID: 28915334.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  29. Amadi B, Besa E, Zyambo K, Kaonga P, Louis-Auguste J, Chandwe K, Tarr PI, Denno DM, Nataro JP, Faubion W, Sailer A, Yeruva S, Brantner T, Murray J, Prendergast AJ, Turner JR, Kelly P. Impaired Barrier Function and Autoantibody Generation in Malnutrition Enteropathy in Zambia. EBioMedicine. 2017 Aug; 22:191-199. PMID: 28750860.
    Citations: 4     Fields:    Translation:Humans
  30. Ma Y, Yue J, Zhang Y, Shi C, Odenwald M, Liang WG, Wei Q, Goel A, Gou X, Zhang J, Chen SY, Tang WJ, Turner JR, Yang F, Liang H, Qin H, Wu X. Erratum: ACF7 regulates inflammatory colitis and intestinal wound response by orchestrating tight junction dynamics. Nat Commun. 2017 07 11; 8:16121. PMID: 28695897.
    Citations:    Fields:    
  31. Tsai PY, Zhang B, He WQ, Zha JM, Odenwald MA, Singh G, Tamura A, Shen L, Sailer A, Yeruva S, Kuo WT, Fu YX, Tsukita S, Turner JR. IL-22 Upregulates Epithelial Claudin-2 to Drive Diarrhea and Enteric Pathogen Clearance. Cell Host Microbe. 2017 Jun 14; 21(6):671-681.e4. PMID: 28618266.
    Citations: 3     Fields:    Translation:AnimalsCells
  32. Weber CR, Turner JR. Dynamic modeling of the tight junction pore pathway. Ann N Y Acad Sci. 2017 06; 1397(1):209-218. PMID: 28605031.
    Citations: 1     Fields:    Translation:AnimalsCells
  33. Edelblum KL, Sharon G, Singh G, Odenwald MA, Sailer A, Cao S, Ravens S, Thomsen I, El Bissati K, McLeod R, Dong C, Gurbuxani S, Prinz I, Mazmanian SK, Turner JR. The Microbiome Activates CD4 T-cell-mediated Immunity to Compensate for Increased Intestinal Permeability. Cell Mol Gastroenterol Hepatol. 2017 Sep; 4(2):285-297. PMID: 28795125.
    Citations: 6     
  34. Ma Y, Yue J, Zhang Y, Shi C, Odenwald M, Liang WG, Wei Q, Goel A, Gou X, Zhang J, Chen SY, Tang WJ, Turner JR, Yang F, Liang H, Qin H, Wu X. ACF7 regulates inflammatory colitis and intestinal wound response by orchestrating tight junction dynamics. Nat Commun. 2017 05 25; 8:15375. PMID: 28541346.
    Citations:    Fields:    Translation:HumansAnimalsCells
  35. Wang LC, Yu Q, Edwards V, Lin B, Qiu J, Turner JR, Stein DC, Song W. Neisseria gonorrhoeae infects the human endocervix by activating non-muscle myosin II-mediated epithelial exfoliation. PLoS Pathog. 2017 Apr; 13(4):e1006269. PMID: 28406994.
    Citations: 1     Fields:    Translation:HumansCells
  36. Choi W, Yeruva S, Turner JR. Contributions of intestinal epithelial barriers to health and disease. Exp Cell Res. 2017 09 01; 358(1):71-77. PMID: 28342899.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  37. Peters SA, Edogawa S, Sundt WJ, Dyer RB, Dalenberg DA, Mazzone A, Singh RJ, Moses N, Smyrk TC, Weber C, Linden DR, MacNaughton WK, Turner JR, Camilleri M, Katzka DA, Farrugia G, Grover M. Constipation-Predominant Irritable Bowel Syndrome Females Have Normal Colonic Barrier and Secretory Function. Am J Gastroenterol. 2017 Jun; 112(6):913-923. PMID: 28323272.
    Citations: 3     Fields:    Translation:HumansCells
  38. Christensen B, Hanauer SB, Erlich J, Kassim O, Gibson PR, Turner JR, Hart J, Rubin DT. Histologic Normalization Occurs in Ulcerative Colitis and Is Associated With Improved Clinical Outcomes. Clin Gastroenterol Hepatol. 2017 Oct; 15(10):1557-1564.e1. PMID: 28238954.
    Citations: 6     Fields:    Translation:Humans
  39. Turner JR. The CMGH Awards. Cell Mol Gastroenterol Hepatol. 2017 Mar; 3(2):129-130. PMID: 28275676.
  40. France MM, Turner JR. The mucosal barrier at a glance. J Cell Sci. 2017 01 15; 130(2):307-314. PMID: 28062847.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  41. Blackwood BP, Wood DR, Yuan C, Nicolas J, De Plaen IG, Farrow KN, Chou P, Turner JR, Hunter CJ. A Role for cAMP and Protein Kinase A in Experimental Necrotizing Enterocolitis. Am J Pathol. 2017 Feb; 187(2):401-417. PMID: 27939131.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  42. Turner JR. A Picture Is Worth a Thousand Words. Cell Mol Gastroenterol Hepatol. 2017 Jan; 3(1):1. PMID: 28174750.
  43. Wu RL, Vazquez-Roque MI, Carlson P, Burton D, Grover M, Camilleri M, Turner JR. Gluten-induced symptoms in diarrhea-predominant irritable bowel syndrome are associated with increased myosin light chain kinase activity and claudin-15 expression. Lab Invest. 2017 01; 97(1):14-23. PMID: 27869798.
    Citations:    Fields:    Translation:HumansCells
  44. Odenwald MA, Turner JR. The intestinal epithelial barrier: a therapeutic target? Nat Rev Gastroenterol Hepatol. 2017 Jan; 14(1):9-21. PMID: 27848962.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  45. Odenwald MA, Choi W, Buckley A, Shashikanth N, Joseph NE, Wang Y, Warren MH, Buschmann MM, Pavlyuk R, Hildebrand J, Margolis B, Fanning AS, Turner JR. ZO-1 interactions with F-actin and occludin direct epithelial polarization and single lumen specification in 3D culture. J Cell Sci. 2017 01 01; 130(1):243-259. PMID: 27802160.
    Citations: 4     Fields:    Translation:HumansCells
  46. Turner JR. PubMed, PubMed Central, and Impact Factor. Cell Mol Gastroenterol Hepatol. 2016 Sep; 2(5):537. PMID: 28174731.
  47. Ronaghan NJ, Shang J, Iablokov V, Zaheer R, Colarusso P, Dion S, Désilets A, Leduc R, Turner JR, MacNaughton WK. The serine protease-mediated increase in intestinal epithelial barrier function is dependent on occludin and requires an intact tight junction. Am J Physiol Gastrointest Liver Physiol. 2016 09 01; 311(3):G466-79. PMID: 27492333.
    Citations: 3     Fields:    Translation:AnimalsCells
  48. Bartelt LA, Bolick DT, Kolling GL, Roche JK, Zaenker EI, Lara AM, Noronha FJ, Cowardin CA, Moore JH, Turner JR, Warren CA, Buck GA, Guerrant RL. Cryptosporidium Priming Is More Effective than Vaccine for Protection against Cryptosporidiosis in a Murine Protein Malnutrition Model. PLoS Negl Trop Dis. 2016 07; 10(7):e0004820. PMID: 27467505.
    Citations: 3     Fields:    Translation:Animals
  49. Omary MB, Cohen DE, El-Omar EM, Jalan R, Low MJ, Nathanson MH, Peek RM, Turner JR. Not all mice are the same: Standardization of animal research data presentation. Hepatology. 2016 06; 63(6):1752-4. PMID: 27205897.
    Citations: 1     Fields:    Translation:Animals
  50. Omary MB, Cohen DE, El-Omar E, Jalan R, Low M, Nathanson M, Peek R, Turner J. Not All Mice Are the Same: Standardization of Animal Research Data Presentation. Gut. 2016 06; 65(6):894-5. PMID: 27197119.
    Citations:    Fields:    Translation:Animals
  51. Omary MB, Cohen DE, El-Omar EM, Jalan R, Low MJ, Nathanson MH, Peek RM, Turner JR. Not All Mice Are the Same: Standardization of Animal Research Data Presentation. Cell Mol Gastroenterol Hepatol. 2016 Jul; 2(4):391-393. PMID: 28174724.
    Citations: 1     
  52. Choi VM, Herrou J, Hecht AL, Teoh WP, Turner JR, Crosson S, Bubeck Wardenburg J. Activation of Bacteroides fragilis toxin by a novel bacterial protease contributes to anaerobic sepsis in mice. Nat Med. 2016 05; 22(5):563-7. PMID: 27089515.
    Citations: 12     Fields:    Translation:AnimalsCells
  53. Omary MB, Cohen DE, El-Omar EM, Jalan R, Low MJ, Nathanson MH, Peek RM, Turner JR. Not All Mice Are the Same: Standardization of Animal Research Data Presentation. Gastroenterology. 2016 06; 150(7):1503-1504. PMID: 27063865.
    Citations: 1     Fields:    Translation:HumansAnimals
  54. Weber MA, Turner JR. Ambulatory Blood Pressure Monitoring: New Directions and Uncertainties Arise From the U.S. Preventive Services Task Force Recommendation on the Diagnosis of Hypertension. J Clin Hypertens (Greenwich). 2016 Mar; 18(3):172-4. PMID: 26899617.
    Citations: 1     Fields:    Translation:Humans
  55. Mir H, Meena AS, Chaudhry KK, Shukla PK, Gangwar R, Manda B, Padala MK, Shen L, Turner JR, Dietrich P, Dragatsis I, Rao R. Occludin deficiency promotes ethanol-induced disruption of colonic epithelial junctions, gut barrier dysfunction and liver damage in mice. Biochim Biophys Acta. 2016 Apr; 1860(4):765-74. PMID: 26721332.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  56. Herrmann JR, Turner JR. Beyond Ussing's chambers: contemporary thoughts on integration of transepithelial transport. Am J Physiol Cell Physiol. 2016 Mar 15; 310(6):C423-31. PMID: 26702131.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  57. Turner JR. Looking Back; Looking Forward! Cell Mol Gastroenterol Hepatol. 2016 Jan; 2(1):1. PMID: 28174698.
  58. Weber CR, Liang GH, Wang Y, Das S, Shen L, Yu AS, Nelson DJ, Turner JR. Claudin-2-dependent paracellular channels are dynamically gated. Elife. 2015 Nov 14; 4:e09906. PMID: 26568313.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  59. Turner JR. CMGH Is Growing! Cell Mol Gastroenterol Hepatol. 2015 Sep; 1(5):453. PMID: 28210692.
  60. Sideri A, Bakirtzi K, Shih DQ, Koon HW, Fleshner P, Arsenescu R, Arsenescu V, Turner JR, Karagiannides I, Pothoulakis C. Substance P mediates pro-inflammatory cytokine release form mesenteric adipocytes in Inflammatory Bowel Disease patients. Cell Mol Gastroenterol Hepatol. 2015 Jul 01; 1(4):420-432. PMID: 26543894.
    Citations: 6     
  61. Powers ME, Becker RE, Sailer A, Turner JR, Bubeck Wardenburg J. Synergistic Action of Staphylococcus aureus a-Toxin on Platelets and Myeloid Lineage Cells Contributes to Lethal Sepsis. Cell Host Microbe. 2015 Jun 10; 17(6):775-87. PMID: 26067604.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  62. Lingaraju A, Long TM, Wang Y, Austin JR, Turner JR. Conceptual barriers to understanding physical barriers. Semin Cell Dev Biol. 2015 Jun; 42:13-21. PMID: 26003050.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  63. Setty M, Discepolo V, Abadie V, Kamhawi S, Mayassi T, Kent A, Ciszewski C, Maglio M, Kistner E, Bhagat G, Semrad C, Kupfer SS, Green PH, Guandalini S, Troncone R, Murray JA, Turner JR, Jabri B. Distinct and Synergistic Contributions of Epithelial Stress and Adaptive Immunity to Functions of Intraepithelial Killer Cells and Active Celiac Disease. Gastroenterology. 2015 Sep; 149(3):681-91.e10. PMID: 26001928.
    Citations: 18     Fields:    Translation:HumansCells
  64. Nalle SC, Turner JR. Intestinal barrier loss as a critical pathogenic link between inflammatory bowel disease and graft-versus-host disease. Mucosal Immunol. 2015 Jul; 8(4):720-30. PMID: 25943273.
    Citations: 16     Fields:    Translation:HumansAnimals
  65. Tripathi AK, Haldar S, Qian J, Beserra A, Suda S, Singh A, Hopfer U, Chen SG, Garrick MD, Turner JR, Knutson MD, Singh N. Prion protein functions as a ferrireductase partner for ZIP14 and DMT1. Free Radic Biol Med. 2015 Jul; 84:322-330. PMID: 25862412.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  66. Edelblum KL, Singh G, Odenwald MA, Lingaraju A, El Bissati K, McLeod R, Sperling AI, Turner JR. ?d Intraepithelial Lymphocyte Migration Limits Transepithelial Pathogen Invasion and Systemic Disease in Mice. Gastroenterology. 2015 Jun; 148(7):1417-26. PMID: 25747597.
    Citations: 16     Fields:    Translation:AnimalsCells
  67. Luther J, Garber JJ, Khalili H, Dave M, Bale SS, Jindal R, Motola DL, Luther S, Bohr S, Jeoung SW, Deshpande V, Singh G, Turner JR, Yarmush ML, Chung RT, Patel SJ. Hepatic Injury in Nonalcoholic Steatohepatitis Contributes to Altered Intestinal Permeability. Cell Mol Gastroenterol Hepatol. 2015 Mar; 1(2):222-232. PMID: 26405687.
    Citations: 22     
  68. Dubnansky EC, Lowe CB, Petrovic TK, Brounstein LM, El-Serag HB, Turner JR, Bishr Omary M. Why send your paper to Gastroenterology: global outreach and partnerships with sister journals, CGH and CMGH, among a menu of offerings. Gastroenterology. 2015 Apr; 148(4):673-8. PMID: 25705033.
    Citations:    Fields:    Translation:Humans
  69. Pan J, Zhang L, Odenwald MA, Shen L, Turner JR, Bergelson JM. Expression of human decay-accelerating factor on intestinal epithelium of transgenic mice does not facilitate infection by the enteral route. J Virol. 2015 Apr; 89(8):4311-8. PMID: 25653430.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  70. Turner JR. A Journey of a Thousand Miles Begins With a Single Step, and Then Another . . . Cell Mol Gastroenterol Hepatol. 2015 Mar; 1(2):121-122. PMID: 28210668.
    Citations: 1     
  71. Chen P, Stärkel P, Turner JR, Ho SB, Schnabl B. Dysbiosis-induced intestinal inflammation activates tumor necrosis factor receptor I and mediates alcoholic liver disease in mice. Hepatology. 2015 Mar; 61(3):883-94. PMID: 25251280.
    Citations: 45     Fields:    Translation:Animals
  72. Sideri A, Stavrakis D, Bowe C, Shih DQ, Fleshner P, Arsenescu V, Arsenescu R, Turner JR, Pothoulakis C, Karagiannides I. Effects of obesity on severity of colitis and cytokine expression in mouse mesenteric fat. Potential role of adiponectin receptor 1. Am J Physiol Gastrointest Liver Physiol. 2015 Apr 01; 308(7):G591-604. PMID: 25591865.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  73. Turner JR, Goldenring JR, Wells RG, Brounstein LM. CMGH: The Revolution Starts Now. Cell Mol Gastroenterol Hepatol. 2015 Jan; 1(1):1. PMID: 28210665.
  74. Haldar S, Tripathi A, Qian J, Beserra A, Suda S, McElwee M, Turner J, Hopfer U, Singh N. Prion protein promotes kidney iron uptake via its ferrireductase activity. J Biol Chem. 2015 Feb 27; 290(9):5512-22. PMID: 25572394.
    Citations: 8     Fields:    Translation:AnimalsCells
  75. Turner JR, Buschmann MM, Romero-Calvo I, Sailer A, Shen L. The role of molecular remodeling in differential regulation of tight junction permeability. Semin Cell Dev Biol. 2014 Dec; 36:204-12. PMID: 25263012.
    Citations: 26     Fields:    Translation:HumansCells
  76. Konda VJ, Koons A, Siddiqui UD, Xiao SY, Turner JR, Waxman I. Optical biopsy approaches in Barrett's esophagus with next-generation optical coherence tomography. Gastrointest Endosc. 2014 Sep; 80(3):516-7. PMID: 25127947.
    Citations: 4     Fields:    Translation:Humans
  77. Chen MM, Zahs A, Brown MM, Ramirez L, Turner JR, Choudhry MA, Kovacs EJ. An alteration of the gut-liver axis drives pulmonary inflammation after intoxication and burn injury in mice. Am J Physiol Gastrointest Liver Physiol. 2014 Oct 01; 307(7):G711-8. PMID: 25104501.
    Citations: 9     Fields:    Translation:AnimalsCells
  78. Yu LC, Shih YA, Wu LL, Lin YD, Kuo WT, Peng WH, Lu KS, Wei SC, Turner JR, Ni YH. Enteric dysbiosis promotes antibiotic-resistant bacterial infection: systemic dissemination of resistant and commensal bacteria through epithelial transcytosis. Am J Physiol Gastrointest Liver Physiol. 2014 Oct 15; 307(8):G824-35. PMID: 25059827.
    Citations: 15     Fields:    Translation:AnimalsCells
  79. Nalle SC, Kwak HA, Edelblum KL, Joseph NE, Singh G, Khramtsova GF, Mortenson ED, Savage PA, Turner JR. Recipient NK cell inactivation and intestinal barrier loss are required for MHC-matched graft-versus-host disease. Sci Transl Med. 2014 Jul 02; 6(243):243ra87. PMID: 24990882.
    Citations: 9     Fields:    Translation:AnimalsCells
  80. Wu LL, Peng WH, Kuo WT, Huang CY, Ni YH, Lu KS, Turner JR, Yu LC. Commensal bacterial endocytosis in epithelial cells is dependent on myosin light chain kinase-activated brush border fanning by interferon-?. Am J Pathol. 2014 Aug; 184(8):2260-74. PMID: 24911373.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  81. Ma K, Malhotra P, Soni V, Hedroug O, Annaba F, Dudeja A, Shen L, Turner JR, Khramtsova EA, Saksena S, Dudeja PK, Gill RK, Alrefai WA. Overactivation of intestinal SREBP2 in mice increases serum cholesterol. PLoS One. 2014; 9(1):e84221. PMID: 24465397.
    Citations: 7     Fields:    Translation:Animals
  82. Perera J, Liu X, Zhou Y, Joseph NE, Meng L, Turner JR, Huang H. Insufficient autoantigen presentation and failure of tolerance in a mouse model of rheumatoid arthritis. Arthritis Rheum. 2013 Nov; 65(11):2847-56. PMID: 23840022.
    Citations: 1     Fields:    Translation:AnimalsCells
  83. Buschmann MM, Shen L, Rajapakse H, Raleigh DR, Wang Y, Wang Y, Lingaraju A, Zha J, Abbott E, McAuley EM, Breskin LA, Wu L, Anderson K, Turner JR, Weber CR. Occludin OCEL-domain interactions are required for maintenance and regulation of the tight junction barrier to macromolecular flux. Mol Biol Cell. 2013 Oct; 24(19):3056-68. PMID: 23924897.
    Citations: 28     Fields:    Translation:HumansCells
  84. Turner ES, Turner JR. Expanding the Lauren classification: a new gastric cancer subtype? Gastroenterology. 2013 Sep; 145(3):505-8. PMID: 23891604.
    Citations: 6     Fields:    Translation:Humans
  85. Rubin DT, Huo D, Kinnucan JA, Sedrak MS, McCullom NE, Bunnag AP, Raun-Royer EP, Cohen RD, Hanauer SB, Hart J, Turner JR. Inflammation is an independent risk factor for colonic neoplasia in patients with ulcerative colitis: a case-control study. Clin Gastroenterol Hepatol. 2013 Dec; 11(12):1601-8.e1-4. PMID: 23872237.
    Citations: 44     Fields:    Translation:Humans
  86. Odenwald MA, Turner JR. Intestinal permeability defects: is it time to treat? Clin Gastroenterol Hepatol. 2013 Sep; 11(9):1075-83. PMID: 23851019.
    Citations: 47     Fields:    Translation:Humans
  87. Su L, Nalle SC, Shen L, Turner ES, Singh G, Breskin LA, Khramtsova EA, Khramtsova G, Tsai PY, Fu YX, Abraham C, Turner JR. TNFR2 activates MLCK-dependent tight junction dysregulation to cause apoptosis-mediated barrier loss and experimental colitis. Gastroenterology. 2013 Aug; 145(2):407-15. PMID: 23619146.
    Citations: 58     Fields:    Translation:AnimalsCells
  88. Bergmann KR, Liu SX, Tian R, Kushnir A, Turner JR, Li HL, Chou PM, Weber CR, De Plaen IG. Bifidobacteria stabilize claudins at tight junctions and prevent intestinal barrier dysfunction in mouse necrotizing enterocolitis. Am J Pathol. 2013 May; 182(5):1595-606. PMID: 23470164.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  89. Turner JR. Reply to Skarupski and Keshavarzian. Gastroenterology. 2013 Apr; 144(4):e22-3. PMID: 23499282.
    Citations:    Fields:    Translation:Humans
  90. Bouyer PG, Tang X, Weber CR, Shen L, Turner JR, Matthews JB. Capsaicin induces NKCC1 internalization and inhibits chloride secretion in colonic epithelial cells independently of TRPV1. Am J Physiol Gastrointest Liver Physiol. 2013 Jan 15; 304(2):G142-56. PMID: 23139219.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  91. Turner JR. Continuing attrition of physician-scientists (CAPS): a preventable syndrome? Gastroenterology. 2012 Sep; 143(3):511-515.e1. PMID: 22824039.
    Citations: 1     Fields:    Translation:Humans
  92. Zahs A, Bird MD, Ramirez L, Turner JR, Choudhry MA, Kovacs EJ. Inhibition of long myosin light-chain kinase activation alleviates intestinal damage after binge ethanol exposure and burn injury. Am J Physiol Gastrointest Liver Physiol. 2012 Sep 15; 303(6):G705-12. PMID: 22790598.
    Citations: 25     Fields:    Translation:Animals
  93. Cunningham KE, Turner JR. Myosin light chain kinase: pulling the strings of epithelial tight junction function. Ann N Y Acad Sci. 2012 Jul; 1258:34-42. PMID: 22731713.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  94. Hwang S, Zimmerman NP, Agle KA, Turner JR, Kumar SN, Dwinell MB. E-cadherin is critical for collective sheet migration and is regulated by the chemokine CXCL12 protein during restitution. J Biol Chem. 2012 Jun 22; 287(26):22227-40. PMID: 22549778.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  95. Edelblum KL, Shen L, Weber CR, Marchiando AM, Clay BS, Wang Y, Prinz I, Malissen B, Sperling AI, Turner JR. Dynamic migration of ?d intraepithelial lymphocytes requires occludin. Proc Natl Acad Sci U S A. 2012 May 01; 109(18):7097-102. PMID: 22511722.
    Citations: 40     Fields:    Translation:AnimalsCells
  96. Nalle SC, Turner JR. Endothelial and epithelial barriers in graft-versus-host disease. Adv Exp Med Biol. 2012; 763:105-31. PMID: 23397621.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  97. Kolodziej LE, Lodolce JP, Chang JE, Schneider JR, Grimm WA, Bartulis SJ, Zhu X, Messer JS, Murphy SF, Reddy N, Turner JR, Boone DL. TNFAIP3 maintains intestinal barrier function and supports epithelial cell tight junctions. PLoS One. 2011; 6(10):e26352. PMID: 22031828.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  98. Zimmerman NP, Kumar SN, Turner JR, Dwinell MB. Cyclic AMP dysregulates intestinal epithelial cell restitution through PKA and RhoA. Inflamm Bowel Dis. 2012 Jun; 18(6):1081-91. PMID: 21993975.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  99. Zahavi EE, Lieberman JA, Donnenberg MS, Nitzan M, Baruch K, Rosenshine I, Turner JR, Melamed-Book N, Feinstein N, Zlotkin-Rivkin E, Aroeti B. Bundle-forming pilus retraction enhances enteropathogenic Escherichia coli infectivity. Mol Biol Cell. 2011 Jul 15; 22(14):2436-47. PMID: 21613538.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  100. Raleigh DR, Boe DM, Yu D, Weber CR, Marchiando AM, Bradford EM, Wang Y, Wu L, Schneeberger EE, Shen L, Turner JR. Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function. J Cell Biol. 2011 May 02; 193(3):565-82. PMID: 21536752.
    Citations: 73     Fields:    Translation:HumansCells
  101. Piontek J, Fritzsche S, Cording J, Richter S, Hartwig J, Walter M, Yu D, Turner JR, Gehring C, Rahn HP, Wolburg H, Blasig IE. Elucidating the principles of the molecular organization of heteropolymeric tight junction strands. Cell Mol Life Sci. 2011 Dec; 68(23):3903-18. PMID: 21533891.
    Citations: 35     Fields:    Translation:HumansCells
  102. Zoccali M, Cipriani N, Fichera A, Turner JR, Krane M. Acute appendicitis secondary to a granular cell tumor of the appendix in a 19-year-old male. J Gastrointest Surg. 2011 Aug; 15(8):1482-5. PMID: 21533589.
    Citations: 1     Fields:    Translation:Humans
  103. Fu J, Wei B, Wen T, Johansson ME, Liu X, Bradford E, Thomsson KA, McGee S, Mansour L, Tong M, McDaniel JM, Sferra TJ, Turner JR, Chen H, Hansson GC, Braun J, Xia L. Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice. J Clin Invest. 2011 Apr; 121(4):1657-66. PMID: 21383503.
    Citations: 102     Fields:    Translation:HumansAnimalsCells
  104. Guan Y, Watson AJ, Marchiando AM, Bradford E, Shen L, Turner JR, Montrose MH. Redistribution of the tight junction protein ZO-1 during physiological shedding of mouse intestinal epithelial cells. Am J Physiol Cell Physiol. 2011 Jun; 300(6):C1404-14. PMID: 21346149.
    Citations: 28     Fields:    Translation:AnimalsCells
  105. Graham WV, Magis AT, Bailey KM, Turner JR, Ostrov DA. Crystallization and preliminary X-ray analysis of the human long myosin light-chain kinase 1-specific domain IgCAM3. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Feb 01; 67(Pt 2):221-3. PMID: 21301090.
    Citations: 1     Fields:    Translation:HumansCells
  106. Marchiando AM, Shen L, Graham WV, Edelblum KL, Duckworth CA, Guan Y, Montrose MH, Turner JR, Watson AJ. The epithelial barrier is maintained by in vivo tight junction expansion during pathologic intestinal epithelial shedding. Gastroenterology. 2011 Apr; 140(4):1208-1218.e1-2. PMID: 21237166.
    Citations: 71     Fields:    Translation:AnimalsCells
  107. Shen L, Weber CR, Raleigh DR, Yu D, Turner JR. Tight junction pore and leak pathways: a dynamic duo. Annu Rev Physiol. 2011; 73:283-309. PMID: 20936941.
    Citations: 169     Fields:    Translation:HumansAnimalsCells
  108. Temkin SM, Turner JR, Lengyel ER. Acute inflammatory reaction following placement of sodium hyaluronate-carboxymethylcellulose barrier in a young woman undergoing gynecologic surgery: a case report. J Reprod Med. 2011 Jan-Feb; 56(1-2):71-4. PMID: 21366131.
    Citations: 1     Fields:    Translation:HumansCells
  109. Paschoud S, Yu D, Pulimeno P, Jond L, Turner JR, Citi S. Cingulin and paracingulin show similar dynamic behaviour, but are recruited independently to junctions. Mol Membr Biol. 2011 Feb; 28(2):123-35. PMID: 21166484.
    Citations: 10     Fields:    Translation:AnimalsCells
  110. Lin R, Murtazina R, Cha B, Chakraborty M, Sarker R, Chen TE, Lin Z, Hogema BM, de Jonge HR, Seidler U, Turner JR, Li X, Kovbasnjuk O, Donowitz M. D-glucose acts via sodium/glucose cotransporter 1 to increase NHE3 in mouse jejunal brush border by a Na+/H+ exchange regulatory factor 2-dependent process. Gastroenterology. 2011 Feb; 140(2):560-71. PMID: 20977906.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  111. Royan SV, Jones RM, Koutsouris A, Roxas JL, Falzari K, Weflen AW, Kim A, Bellmeyer A, Turner JR, Neish AS, Rhee KJ, Viswanathan VK, Hecht GA. Enteropathogenic E. coli non-LEE encoded effectors NleH1 and NleH2 attenuate NF-?B activation. Mol Microbiol. 2010 Dec; 78(5):1232-45. PMID: 21091507.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  112. Lopez JP, Turner JR, Philipson LH. Glucose-induced ERM protein activation and translocation regulates insulin secretion. Am J Physiol Endocrinol Metab. 2010 Nov; 299(5):E772-85. PMID: 20739507.
    Citations: 8     Fields:    Translation:AnimalsCells
  113. Pekow JR, Hetzel JT, Rothe JA, Hanauer SB, Turner JR, Hart J, Noffsinger A, Huo D, Rubin DT. Outcome after surveillance of low-grade and indefinite dysplasia in patients with ulcerative colitis. Inflamm Bowel Dis. 2010 Aug; 16(8):1352-6. PMID: 20027656.
    Citations: 16     Fields:    Translation:HumansPHPublic Health
  114. Li H, Liu XS, Yang X, Wang Y, Wang Y, Turner JR, Liu X. Phosphorylation of CLIP-170 by Plk1 and CK2 promotes timely formation of kinetochore-microtubule attachments. EMBO J. 2010 Sep 01; 29(17):2953-65. PMID: 20664522.
    Citations: 41     Fields:    Translation:HumansCells
  115. Rajapakse HE, Gahlaut N, Mohandessi S, Yu D, Turner JR, Miller LW. Time-resolved luminescence resonance energy transfer imaging of protein-protein interactions in living cells. Proc Natl Acad Sci U S A. 2010 Aug 03; 107(31):13582-7. PMID: 20643966.
    Citations: 27     Fields:    Translation:AnimalsCells
  116. Lissner S, Nold L, Hsieh CJ, Turner JR, Gregor M, Graeve L, Lamprecht G. Activity and PI3-kinase dependent trafficking of the intestinal anion exchanger downregulated in adenoma depend on its PDZ interaction and on lipid rafts. Am J Physiol Gastrointest Liver Physiol. 2010 Oct; 299(4):G907-20. PMID: 20634435.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  117. Chen L, Park SM, Turner JR, Peter ME. Cell death in the colonic epithelium during inflammatory bowel diseases: CD95/Fas and beyond. Inflamm Bowel Dis. 2010 Jun; 16(6):1071-6. PMID: 20049945.
    Citations: 11     Fields:    Translation:HumansAnimals
  118. Park SM, Chen L, Zhang M, Ashton-Rickardt P, Turner JR, Peter ME. CD95 is cytoprotective for intestinal epithelial cells in colitis. Inflamm Bowel Dis. 2010 Jun; 16(6):1063-70. PMID: 20049944.
    Citations: 9     Fields:    Translation:Animals
  119. Chen L, Park SM, Tumanov AV, Hau A, Sawada K, Feig C, Turner JR, Fu YX, Romero IL, Lengyel E, Peter ME. CD95 promotes tumour growth. Nature. 2010 May 27; 465(7297):492-6. PMID: 20505730.
    Citations: 121     Fields:    Translation:HumansAnimalsCells
  120. Lee G, Goretsky T, Managlia E, Dirisina R, Singh AP, Brown JB, May R, Yang GY, Ragheb JW, Evers BM, Weber CR, Turner JR, He XC, Katzman RB, Li L, Barrett TA. Phosphoinositide 3-kinase signaling mediates beta-catenin activation in intestinal epithelial stem and progenitor cells in colitis. Gastroenterology. 2010 Sep; 139(3):869-81, 881.e1-9. PMID: 20580720.
    Citations: 65     Fields:    Translation:HumansAnimalsCells
  121. Yu D, Marchiando AM, Weber CR, Raleigh DR, Wang Y, Shen L, Turner JR. MLCK-dependent exchange and actin binding region-dependent anchoring of ZO-1 regulate tight junction barrier function. Proc Natl Acad Sci U S A. 2010 May 04; 107(18):8237-41. PMID: 20404178.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  122. Marchiando AM, Shen L, Graham WV, Weber CR, Schwarz BT, Austin JR, Raleigh DR, Guan Y, Watson AJ, Montrose MH, Turner JR. Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo. J Cell Biol. 2010 Apr 05; 189(1):111-26. PMID: 20351069.
    Citations: 141     Fields:    Translation:AnimalsCells
  123. Weber CR, Raleigh DR, Su L, Shen L, Sullivan EA, Wang Y, Turner JR. Epithelial myosin light chain kinase activation induces mucosal interleukin-13 expression to alter tight junction ion selectivity. J Biol Chem. 2010 Apr 16; 285(16):12037-46. PMID: 20177070.
    Citations: 81     Fields:    Translation:HumansAnimalsCells
  124. Raleigh DR, Marchiando AM, Zhang Y, Shen L, Sasaki H, Wang Y, Long M, Turner JR. Tight junction-associated MARVEL proteins marveld3, tricellulin, and occludin have distinct but overlapping functions. Mol Biol Cell. 2010 Apr 01; 21(7):1200-13. PMID: 20164257.
    Citations: 85     Fields:    Translation:HumansAnimalsCells
  125. Mirzapoiazova T, Moitra J, Moreno-Vinasco L, Sammani S, Turner JR, Chiang ET, Evenoski C, Wang T, Singleton PA, Huang Y, Lussier YA, Watterson DM, Dudek SM, Garcia JG. Non-muscle myosin light chain kinase isoform is a viable molecular target in acute inflammatory lung injury. Am J Respir Cell Mol Biol. 2011 Jan; 44(1):40-52. PMID: 20139351.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  126. Marchiando AM, Graham WV, Turner JR. Epithelial barriers in homeostasis and disease. Annu Rev Pathol. 2010; 5:119-44. PMID: 20078218.
    Citations: 130     Fields:    Translation:HumansAnimalsCells
  127. Turner HL, Turner JR. Good fences make good neighbors: Gastrointestinal mucosal structure. Gut Microbes. 2010 Jan; 1(1):22-29. PMID: 21327113.
    Citations: 7     Fields:    
  128. Tang Y, Clayburgh DR, Mittal N, Goretsky T, Dirisina R, Zhang Z, Kron M, Ivancic D, Katzman RB, Grimm G, Lee G, Fryer J, Nusrat A, Turner JR, Barrett TA. Epithelial NF-kappaB enhances transmucosal fluid movement by altering tight junction protein composition after T cell activation. Am J Pathol. 2010 Jan; 176(1):158-67. PMID: 20008138.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  129. Nalle SC, Turner JR. Menetrier's disease therapy: rebooting mucosal signaling. Sci Transl Med. 2009 Nov 25; 1(8):8ps10. PMID: 20368184.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  130. Shen L, Su L, Turner JR. Mechanisms and functional implications of intestinal barrier defects. Dig Dis. 2009; 27(4):443-9. PMID: 19897958.
    Citations: 31     Fields:    Translation:HumansCells
  131. Turner JR. Intestinal mucosal barrier function in health and disease. Nat Rev Immunol. 2009 Nov; 9(11):799-809. PMID: 19855405.
    Citations: 550     Fields:    Translation:HumansAnimalsCells
  132. Mykoniatis A, Shen L, Fedor-Chaiken M, Tang J, Tang X, Worrell RT, Delpire E, Turner JR, Matlin KS, Bouyer P, Matthews JB. Phorbol 12-myristate 13-acetate-induced endocytosis of the Na-K-2Cl cotransporter in MDCK cells is associated with a clathrin-dependent pathway. Am J Physiol Cell Physiol. 2010 Jan; 298(1):C85-97. PMID: 19864322.
    Citations: 8     Fields:    Translation:AnimalsCells
  133. Chen B, Yates E, Huang Y, Kogut P, Ma L, Turner JR, Tao Y, Camoretti-Mercado B, Lang D, Svensson EC, Garcia JG, Gruber PJ, Morrisey EE, Solway J. Alternative promoter and GATA5 transcripts in mouse. Am J Physiol Gastrointest Liver Physiol. 2009 Dec; 297(6):G1214-22. PMID: 19779014.
    Citations: 6     Fields:    Translation:AnimalsCells
  134. Esmaili A, Nazir SF, Borthakur A, Yu D, Turner JR, Saksena S, Singla A, Hecht GA, Alrefai WA, Gill RK. Enteropathogenic Escherichia coli infection inhibits intestinal serotonin transporter function and expression. Gastroenterology. 2009 Dec; 137(6):2074-83. PMID: 19747920.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  135. Snoeks L, Weber CR, Wasland K, Turner JR, Vainder C, Qi W, Savkovic SD. Tumor suppressor FOXO3 participates in the regulation of intestinal inflammation. Lab Invest. 2009 Sep; 89(9):1053-62. PMID: 19636295.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  136. Edelblum KL, Turner JR. The tight junction in inflammatory disease: communication breakdown. Curr Opin Pharmacol. 2009 Dec; 9(6):715-20. PMID: 19632896.
    Citations: 65     Fields:    Translation:HumansAnimalsCells
  137. Lamprecht G, Hsieh CJ, Lissner S, Nold L, Heil A, Gaco V, Schäfer J, Turner JR, Gregor M. Intestinal anion exchanger down-regulated in adenoma (DRA) is inhibited by intracellular calcium. J Biol Chem. 2009 Jul 17; 284(29):19744-53. PMID: 19447883.
    Citations: 12     Fields:    Translation:HumansCells
  138. Graham WV, Marchiando AM, Shen L, Turner JR. No static at all. Ann N Y Acad Sci. 2009 May; 1165:314-22. PMID: 19538322.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  139. Lamprecht G, Gaco V, Turner JR, Natour D, Gregor M. Regulation of the intestinal anion exchanger DRA (downregulated in adenoma). Ann N Y Acad Sci. 2009 May; 1165:261-6. PMID: 19538314.
    Citations: 6     Fields:    Translation:HumansCells
  140. Oto A, Zhu F, Kulkarni K, Karczmar GS, Turner JR, Rubin D. Evaluation of diffusion-weighted MR imaging for detection of bowel inflammation in patients with Crohn's disease. Acad Radiol. 2009 May; 16(5):597-603. PMID: 19282206.
    Citations: 46     Fields:    Translation:Humans
  141. Nalle SC, Turner JR. Epithelium, tear down this wall! Cell Host Microbe. 2009 Jan 22; 5(1):1-2. PMID: 19154980.
    Citations:    Fields:    Translation:HumansAnimalsCells
  142. Mukherjee A, Morosky SA, Shen L, Weber CR, Turner JR, Kim KS, Wang T, Coyne CB. Retinoic acid-induced gene-1 (RIG-I) associates with the actin cytoskeleton via caspase activation and recruitment domain-dependent interactions. J Biol Chem. 2009 Mar 06; 284(10):6486-94. PMID: 19122199.
    Citations: 20     Fields:    Translation:HumansCells
  143. Suzuki T, Elias BC, Seth A, Shen L, Turner JR, Giorgianni F, Desiderio D, Guntaka R, Rao R. PKC eta regulates occludin phosphorylation and epithelial tight junction integrity. Proc Natl Acad Sci U S A. 2009 Jan 06; 106(1):61-6. PMID: 19114660.
    Citations: 66     Fields:    Translation:HumansAnimalsCells
  144. Liu S, Yang W, Shen L, Turner JR, Coyne CB, Wang T. Tight junction proteins claudin-1 and occludin control hepatitis C virus entry and are downregulated during infection to prevent superinfection. J Virol. 2009 Feb; 83(4):2011-4. PMID: 19052094.
    Citations: 133     Fields:    Translation:HumansCells
  145. Crawford JM, Ketcham CM, Braylan R, Morel L, Terada N, Turner JR, Yachnis AT. The publishing game: reflections of an editorial team. Lab Invest. 2008 Dec; 88(12):1258-63. PMID: 19020521.
    Citations:    Fields:    
  146. Elias BC, Suzuki T, Seth A, Giorgianni F, Kale G, Shen L, Turner JR, Naren A, Desiderio DM, Rao R. Phosphorylation of Tyr-398 and Tyr-402 in occludin prevents its interaction with ZO-1 and destabilizes its assembly at the tight junctions. J Biol Chem. 2009 Jan 16; 284(3):1559-69. PMID: 19017651.
    Citations: 68     Fields:    Translation:HumansAnimalsCells
  147. Shen L, Turner JR. Intercellular junctions: actin the PARt. Curr Biol. 2008 Nov 11; 18(21):R1014-7. PMID: 19000799.
    Citations: 3     Fields:    Translation:AnimalsCells
  148. Su L, Shen L, Clayburgh DR, Nalle SC, Sullivan EA, Meddings JB, Abraham C, Turner JR. Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis. Gastroenterology. 2009 Feb; 136(2):551-63. PMID: 19027740.
    Citations: 122     Fields:    Translation:AnimalsCells
  149. Wroblewski LE, Shen L, Ogden S, Romero-Gallo J, Lapierre LA, Israel DA, Turner JR, Peek RM. Helicobacter pylori dysregulation of gastric epithelial tight junctions by urease-mediated myosin II activation. Gastroenterology. 2009 Jan; 136(1):236-46. PMID: 18996125.
    Citations: 60     Fields:    Translation:AnimalsCells
  150. Weber CR, Nalle SC, Tretiakova M, Rubin DT, Turner JR. Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation. Lab Invest. 2008 Oct; 88(10):1110-20. PMID: 18711353.
    Citations: 80     Fields:    Translation:HumansCells
  151. Snoeks L, Weber CR, Turner JR, Bhattacharyya M, Wasland K, Savkovic SD. Tumor suppressor Foxo3a is involved in the regulation of lipopolysaccharide-induced interleukin-8 in intestinal HT-29 cells. Infect Immun. 2008 Oct; 76(10):4677-85. PMID: 18678662.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  152. Gill RK, Shen L, Turner JR, Saksena S, Alrefai WA, Pant N, Esmaili A, Dwivedi A, Ramaswamy K, Dudeja PK. Serotonin modifies cytoskeleton and brush-border membrane architecture in human intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2008 Oct; 295(4):G700-8. PMID: 18669621.
    Citations: 2     Fields:    Translation:HumansCells
  153. Purohit V, Bode JC, Bode C, Brenner DA, Choudhry MA, Hamilton F, Kang YJ, Keshavarzian A, Rao R, Sartor RB, Swanson C, Turner JR. Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposium. Alcohol. 2008 Aug; 42(5):349-61. PMID: 18504085.
    Citations: 92     Fields:    Translation:HumansAnimalsCells
  154. Shen L, Weber CR, Turner JR. The tight junction protein complex undergoes rapid and continuous molecular remodeling at steady state. J Cell Biol. 2008 May 19; 181(4):683-95. PMID: 18474622.
    Citations: 115     Fields:    Translation:HumansAnimalsCells
  155. Zaborina O, Holbrook C, Chen Y, Long J, Zaborin A, Morozova I, Fernandez H, Wang Y, Turner JR, Alverdy JC. Structure-function aspects of PstS in multi-drug-resistant Pseudomonas aeruginosa. PLoS Pathog. 2008 Feb 08; 4(2):e43. PMID: 18282104.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  156. Moitra J, Evenoski C, Sammani S, Wadgaonkar R, Turner JR, Ma SF, Garcia JG. A transgenic mouse with vascular endothelial over-expression of the non-muscle myosin light chain kinase-2 isoform is susceptible to inflammatory lung injury: role of sexual dimorphism and age. Transl Res. 2008 Mar; 151(3):141-53. PMID: 18279813.
    Citations: 19     Fields:    Translation:HumansAnimals
  157. Yu LC, Huang CY, Kuo WT, Sayer H, Turner JR, Buret AG. SGLT-1-mediated glucose uptake protects human intestinal epithelial cells against Giardia duodenalis-induced apoptosis. Int J Parasitol. 2008 Jul; 38(8-9):923-34. PMID: 18281046.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  158. Annaba F, Sarwar Z, Kumar P, Saksena S, Turner JR, Dudeja PK, Gill RK, Alrefai WA. Modulation of ileal bile acid transporter (ASBT) activity by depletion of plasma membrane cholesterol: association with lipid rafts. Am J Physiol Gastrointest Liver Physiol. 2008 Feb; 294(2):G489-97. PMID: 18063707.
    Citations: 15     Fields:    Translation:HumansCells
  159. Gill RK, Pant N, Saksena S, Singla A, Nazir TM, Vohwinkel L, Turner JR, Goldstein J, Alrefai WA, Dudeja PK. Function, expression, and characterization of the serotonin transporter in the native human intestine. Am J Physiol Gastrointest Liver Physiol. 2008 Jan; 294(1):G254-62. PMID: 17991706.
    Citations: 20     Fields:    Translation:HumansCells
  160. Coyne CB, Shen L, Turner JR, Bergelson JM. Coxsackievirus entry across epithelial tight junctions requires occludin and the small GTPases Rab34 and Rab5. Cell Host Microbe. 2007 Sep 13; 2(3):181-92. PMID: 18005733.
    Citations: 101     Fields:    Translation:HumansCells
  161. Yu D, Turner JR. Stimulus-induced reorganization of tight junction structure: the role of membrane traffic. Biochim Biophys Acta. 2008 Mar; 1778(3):709-16. PMID: 17915190.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  162. Treede I, Braun A, Sparla R, Kühnel M, Giese T, Turner JR, Anes E, Kulaksiz H, Füllekrug J, Stremmel W, Griffiths G, Ehehalt R. Anti-inflammatory effects of phosphatidylcholine. J Biol Chem. 2007 Sep 14; 282(37):27155-64. PMID: 17636253.
    Citations: 35     Fields:    Translation:HumansCells
  163. Moyer RA, Wendt MK, Johanesen PA, Turner JR, Dwinell MB. Rho activation regulates CXCL12 chemokine stimulated actin rearrangement and restitution in model intestinal epithelia. Lab Invest. 2007 Aug; 87(8):807-17. PMID: 17572689.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  164. Sun Q, Weber CR, Sohail A, Bernardo MM, Toth M, Zhao H, Turner JR, Fridman R. MMP25 (MT6-MMP) is highly expressed in human colon cancer, promotes tumor growth, and exhibits unique biochemical properties. J Biol Chem. 2007 Jul 27; 282(30):21998-2010. PMID: 17513868.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  165. Su L, Turner JR. Got guts? Need nerve! Gastroenterology. 2007 Apr; 132(4):1615-8. PMID: 17418164.
    Citations:    Fields:    Translation:HumansAnimalsCells
  166. Zaborina O, Lepine F, Xiao G, Valuckaite V, Chen Y, Li T, Ciancio M, Zaborin A, Petrof EO, Petroff E, Turner JR, Rahme LG, Chang E, Alverdy JC. Dynorphin activates quorum sensing quinolone signaling in Pseudomonas aeruginosa. PLoS Pathog. 2007 Mar; 3(3):e35. PMID: 17367209.
    Citations: 64     Fields:    Translation:AnimalsCells
  167. Schwarz BT, Wang F, Shen L, Clayburgh DR, Su L, Wang Y, Fu YX, Turner JR. LIGHT signals directly to intestinal epithelia to cause barrier dysfunction via cytoskeletal and endocytic mechanisms. Gastroenterology. 2007 Jun; 132(7):2383-94. PMID: 17570213.
    Citations: 68     Fields:    Translation:HumansAnimalsCells
  168. Gill RK, Borthakur A, Hodges K, Turner JR, Clayburgh DR, Saksena S, Zaheer A, Ramaswamy K, Hecht G, Dudeja PK. Mechanism underlying inhibition of intestinal apical Cl/OH exchange following infection with enteropathogenic E. coli. J Clin Invest. 2007 Feb; 117(2):428-37. PMID: 17256057.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  169. Fichera A, Little N, Jagadeeswaran S, Dougherty U, Sehdev A, Mustafi R, Cerda S, Yuan W, Khare S, Tretiakova M, Gong C, Tallerico M, Cohen G, Joseph L, Hart J, Turner JR, Bissonnette M. Epidermal growth factor receptor signaling is required for microadenoma formation in the mouse azoxymethane model of colonic carcinogenesis. Cancer Res. 2007 Jan 15; 67(2):827-35. PMID: 17234795.
    Citations: 22     Fields:    Translation:AnimalsCells
  170. Weber CR, Turner JR. Inflammatory bowel disease: is it really just another break in the wall? Gut. 2007 Jan; 56(1):6-8. PMID: 17172583.
    Citations: 43     Fields:    Translation:HumansCells
  171. Turner JR. Molecular basis of epithelial barrier regulation: from basic mechanisms to clinical application. Am J Pathol. 2006 Dec; 169(6):1901-9. PMID: 17148655.
    Citations: 154     Fields:    Translation:HumansCells
  172. Rubin DT, Turner JR. Surveillance of dysplasia in inflammatory bowel disease: The gastroenterologist-pathologist partnership. Clin Gastroenterol Hepatol. 2006 Nov; 4(11):1309-13. PMID: 17110299.
    Citations: 8     Fields:    Translation:Humans
  173. Clayburgh DR, Musch MW, Leitges M, Fu YX, Turner JR. Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo. J Clin Invest. 2006 Oct; 116(10):2682-94. PMID: 17016558.
    Citations: 77     Fields:    Translation:Animals