Harvard Catalyst Profiles

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Christian William Johnson, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Johnson CW, Seo HS, Terrell EM, Yang MH, KleinJan F, Gebregiworgis T, Gasmi-Seabrook GMC, Geffken EA, Lakhani J, Song K, Bashyal P, Popow O, Paulo JA, Liu A, Mattos C, Marshall CB, Ikura M, Morrison DK, Dhe-Paganon S, Haigis KM. Regulation of GTPase function by autophosphorylation. Mol Cell. 2022 Mar 03; 82(5):950-968.e14. PMID: 35202574.
    Citations:    Fields:    
  2. Johnson CW, Lin YJ, Reid D, Parker J, Pavlopoulos S, Dischinger P, Graveel C, Aguirre AJ, Steensma M, Haigis KM, Mattos C. Isoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas G13D. Cell Rep. 2019 08 06; 28(6):1538-1550.e7. PMID: 31390567.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  3. Poulin EJ, Bera AK, Lu J, Lin YJ, Strasser SD, Paulo JA, Huang TQ, Morales C, Yan W, Cook J, Nowak JA, Brubaker DK, Joughin BA, Johnson CW, DeStefanis RA, Ghazi PC, Gondi S, Wales TE, Iacob RE, Bogdanova L, Gierut JJ, Li Y, Engen JR, Perez-Mancera PA, Braun BS, Gygi SP, Lauffenburger DA, Westover KD, Haigis KM. Tissue-Specific Oncogenic Activity of KRASA146T. Cancer Discov. 2019 06; 9(6):738-755. PMID: 30952657.
    Citations: 48     Fields:    Translation:HumansCells
  4. Johnson CW, Reid D, Parker JA, Salter S, Knihtila R, Kuzmic P, Mattos C. The small GTPases K-Ras, N-Ras, and H-Ras have distinct biochemical properties determined by allosteric effects. J Biol Chem. 2017 08 04; 292(31):12981-12993. PMID: 28630043.
    Citations: 42     Fields:    Translation:HumansCells
  5. Johnson CW, Buhrman G, Ting PY, Colicelli J, Mattos C. Expression, purification, crystallization and X-ray data collection for RAS and its mutants. Data Brief. 2016 Mar; 6:423-7. PMID: 26866052.
    Citations: 8     
  6. Ting PY, Johnson CW, Fang C, Cao X, Graeber TG, Mattos C, Colicelli J. Tyrosine phosphorylation of RAS by ABL allosterically enhances effector binding. FASEB J. 2015 Sep; 29(9):3750-61. PMID: 25999467.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  7. Kearney BM, Johnson CW, Roberts DM, Swartz P, Mattos C. DRoP: a water analysis program identifies Ras-GTP-specific pathway of communication between membrane-interacting regions and the active site. J Mol Biol. 2014 Feb 06; 426(3):611-29. PMID: 24189050.
    Citations: 20     Fields:    Translation:Cells
  8. Johnson CW, Mattos C. The allosteric switch and conformational states in Ras GTPase affected by small molecules. Enzymes. 2013; 33 Pt A:41-67. PMID: 25033800.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.