Harvard Catalyst Profiles

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Kiera Leigh Clayton, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. DP2AI154438 (CLAYTON, KIERA L.) Aug 1, 2021 - Jul 31, 2026
    NIH
    Characterizing Macrophages as Hide-Outs for Chronic Pathogens
    Role: Principal Investigator
  2. F32AI143480 (CLAYTON, KIERA L.) Feb 1, 2019 - Jan 31, 2021
    NIH
    Characterization of CD8+ T cell killer activity and the mechanisms responsible for detachment from dead target cells
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Clayton KL, Mylvaganam G, Villasmil-Ocando A, Stuart H, Maus MV, Rashidian M, Ploegh HL, Walker BD. HIV-infected macrophages resist efficient NK cell-mediated killing while preserving inflammatory cytokine responses. Cell Host Microbe. 2021 03 10; 29(3):435-447.e9. PMID: 33571449.
    Citations: 1     Fields:    
  2. Garcia-Beltran WF, Lam EC, Astudillo MG, Yang D, Miller TE, Feldman J, Hauser BM, Caradonna TM, Clayton KL, Nitido AD, Murali MR, Alter G, Charles RC, Dighe A, Branda JA, Lennerz JK, Lingwood D, Schmidt AG, Iafrate AJ, Balazs AB. COVID-19-neutralizing antibodies predict disease severity and survival. Cell. 2021 01 21; 184(2):476-488.e11. PMID: 33412089.
    Citations: 53     Fields:    Translation:HumansCells
  3. Garcia-Beltran WF, Lam EC, Astudillo MG, Yang D, Miller TE, Feldman J, Hauser BM, Caradonna TM, Clayton KL, Nitido AD, Murali MR, Alter G, Charles RC, Dighe A, Branda JA, Lennerz JK, Lingwood D, Schmidt AG, Iafrate AJ, Balazs AB. COVID-19 neutralizing antibodies predict disease severity and survival. medRxiv. 2020 Oct 20. PMID: 33106822.
    Citations:    
  4. Yuan Y, Brouchon J, Calvo-Calle JM, Xia J, Sun L, Zhang X, Clayton KL, Ye F, Weitz DA, Heyman JA. Droplet encapsulation improves accuracy of immune cell cytokine capture assays. Lab Chip. 2020 04 21; 20(8):1513-1520. PMID: 32242586.
    Citations: 2     Fields:    Translation:Cells
  5. Liu J, Clayton K, Gao W, Li Y, Zealey C, Budylowski P, Schwartz J, Yue FY, Bie Y, Rini J, Ostrowski M. Trimeric HIV-1 gp140 fused with APRIL, BAFF, and CD40L on the mucosal gp140-specific antibody responses in mice. Vaccine. 2020 02 24; 38(9):2149-2159. PMID: 32014267.
    Citations: 2     Fields:    Translation:AnimalsCells
  6. Siciliano V, DiAndreth B, Monel B, Beal J, Huh J, Clayton KL, Wroblewska L, McKeon A, Walker BD, Weiss R. Engineering modular intracellular protein sensor-actuator devices. Nat Commun. 2018 05 14; 9(1):1881. PMID: 29760420.
    Citations: 9     Fields:    Translation:HumansCells
  7. Clayton KL, Collins DR, Lengieza J, Ghebremichael M, Dotiwala F, Lieberman J, Walker BD. Resistance of HIV-infected macrophages to CD8+ T lymphocyte-mediated killing drives activation of the immune system. Nat Immunol. 2018 05; 19(5):475-486. PMID: 29670239.
    Citations: 25     Fields:    Translation:HumansCells
  8. Clayton KL, Ostrowski MM. Editorial: Countering immune regulation: sTim-ulating SLE disease pathogenesis. J Leukoc Biol. 2017 12; 102(6):1286-1288. PMID: 29191867.
    Citations:    Fields:    
  9. Clayton KL, Garcia JV, Clements JE, Walker BD. HIV Infection of Macrophages: Implications for Pathogenesis and Cure. Pathog Immun. 2017; 2(2):179-192. PMID: 28752134.
    Citations: 30     
  10. Schwartz JA, Clayton KL, Mujib S, Zhang H, Rahman AK, Liu J, Yue FY, Benko E, Kovacs C, Ostrowski MA. Tim-3 is a Marker of Plasmacytoid Dendritic Cell Dysfunction during HIV Infection and Is Associated with the Recruitment of IRF7 and p85 into Lysosomes and with the Submembrane Displacement of TLR9. J Immunol. 2017 04 15; 198(8):3181-3194. PMID: 28264968.
    Citations: 14     Fields:    Translation:HumansCells
  11. Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, Pyzik M, Ostrowski MA, Glickman JN, Rudd CE, Ploegh HL, Franke A, Petsko GA, Kuchroo VK, Blumberg RS. Corrigendum: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion. Nature. 2016 08 18; 536(7616):359. PMID: 26982724.
    Citations: 15     Fields:    
  12. Chew GM, Fujita T, Webb GM, Burwitz BJ, Wu HL, Reed JS, Hammond KB, Clayton KL, Ishii N, Abdel-Mohsen M, Liegler T, Mitchell BI, Hecht FM, Ostrowski M, Shikuma CM, Hansen SG, Maurer M, Korman AJ, Deeks SG, Sacha JB, Ndhlovu LC. TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection. PLoS Pathog. 2016 Jan; 12(1):e1005349. PMID: 26741490.
    Citations: 98     Fields:    Translation:HumansAnimalsCells
  13. Clayton KL, Douglas-Vail MB, Nur-ur Rahman AK, Medcalf KE, Xie IY, Chew GM, Tandon R, Lanteri MC, Norris PJ, Deeks SG, Ndhlovu LC, Ostrowski MA. Soluble T cell immunoglobulin mucin domain 3 is shed from CD8+ T cells by the sheddase ADAM10, is increased in plasma during untreated HIV infection, and correlates with HIV disease progression. J Virol. 2015 Apr; 89(7):3723-36. PMID: 25609823.
    Citations: 23     Fields:    Translation:HumansCells
  14. Fujita T, Burwitz BJ, Chew GM, Reed JS, Pathak R, Seger E, Clayton KL, Rini JM, Ostrowski MA, Ishii N, Kuroda MJ, Hansen SG, Sacha JB, Ndhlovu LC. Expansion of dysfunctional Tim-3-expressing effector memory CD8+ T cells during simian immunodeficiency virus infection in rhesus macaques. J Immunol. 2014 Dec 01; 193(11):5576-83. PMID: 25348621.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  15. Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, Pyzik M, Ostrowski MA, Glickman JN, Rudd CE, Ploegh HL, Franke A, Petsko GA, Kuchroo VK, Blumberg RS. CEACAM1 regulates TIM-3-mediated tolerance and exhaustion. Nature. 2015 01 15; 517(7534):386-90. PMID: 25363763.
    Citations: 173     Fields:    Translation:HumansAnimalsCells
  16. Liu J, Zhan W, Kim CJ, Clayton K, Zhao H, Lee E, Cao JC, Ziegler B, Gregor A, Yue FY, Huibner S, MacParland S, Schwartz J, Song HH, Benko E, Gyenes G, Kovacs C, Kaul R, Ostrowski M. IL-10-producing B cells are induced early in HIV-1 infection and suppress HIV-1-specific T cell responses. PLoS One. 2014; 9(2):e89236. PMID: 24586620.
    Citations: 38     Fields:    Translation:HumansCells
  17. Clayton KL, Haaland MS, Douglas-Vail MB, Mujib S, Chew GM, Ndhlovu LC, Ostrowski MA. T cell Ig and mucin domain-containing protein 3 is recruited to the immune synapse, disrupts stable synapse formation, and associates with receptor phosphatases. J Immunol. 2014 Jan 15; 192(2):782-91. PMID: 24337741.
    Citations: 35     Fields:    Translation:HumansCells
  18. Jones RB, Garrison KE, Mujib S, Mihajlovic V, Aidarus N, Hunter DV, Martin E, John VM, Zhan W, Faruk NF, Gyenes G, Sheppard NC, Priumboom-Brees IM, Goodwin DA, Chen L, Rieger M, Muscat-King S, Loudon PT, Stanley C, Holditch SJ, Wong JC, Clayton K, Duan E, Song H, Xu Y, SenGupta D, Tandon R, Sacha JB, Brockman MA, Benko E, Kovacs C, Nixon DF, Ostrowski MA. HERV-K-specific T cells eliminate diverse HIV-1/2 and SIV primary isolates. J Clin Invest. 2012 Dec; 122(12):4473-89. PMID: 23143309.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  19. Sakhdari A, Mujib S, Vali B, Yue FY, MacParland S, Clayton K, Jones RB, Liu J, Lee EY, Benko E, Kovacs C, Gommerman J, Kaul R, Ostrowski MA. Tim-3 negatively regulates cytotoxicity in exhausted CD8+ T cells in HIV infection. PLoS One. 2012; 7(7):e40146. PMID: 22792231.
    Citations: 44     Fields:    Translation:HumansCells
  20. Mujib S, Jones RB, Lo C, Aidarus N, Clayton K, Sakhdari A, Benko E, Kovacs C, Ostrowski MA. Antigen-independent induction of Tim-3 expression on human T cells by the common ?-chain cytokines IL-2, IL-7, IL-15, and IL-21 is associated with proliferation and is dependent on the phosphoinositide 3-kinase pathway. J Immunol. 2012 Apr 15; 188(8):3745-56. PMID: 22422881.
    Citations: 38     Fields:    Translation:HumansCells
  21. Vali B, Jones RB, Sakhdari A, Sheth PM, Clayton K, Yue FY, Gyenes G, Wong D, Klein MB, Saeed S, Benko E, Kovacs C, Kaul R, Ostrowski MA. HCV-specific T cells in HCV/HIV co-infection show elevated frequencies of dual Tim-3/PD-1 expression that correlate with liver disease progression. Eur J Immunol. 2010 Sep; 40(9):2493-505. PMID: 20623550.
    Citations: 58     Fields:    Translation:HumansCells
  22. Cochrane A, Murley LL, Gao M, Wong R, Clayton K, Brufatto N, Canadien V, Mamelak D, Chen T, Richards D, Zeghouf M, Greenblatt J, Burks C, Frappier L. Stable complex formation between HIV Rev and the nucleosome assembly protein, NAP1, affects Rev function. Virology. 2009 May 25; 388(1):103-11. PMID: 19339032.
    Citations: 10     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.