Harvard Catalyst Profiles

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Wencai Zhang, Ph.D.


2017 - 2018
NIH T32 Award
2016 - 2017
Award for YALE SPORE in Lung Cancer Career Development Program
2012 - 2013
GIS Outstanding Performance Award


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Wen Cai Zhang, Julie M. Wells, Kin-Hoe Chow, He Huang, Min Yuan, Tanvi Saxena, Mary Ann Melnick, Katerina Politi, John M. Asara, Daniel B. Costa, Carol J. Bult, Frank J. Slack. miR-147b-mediated TCA cycle dysfunction and pseudohypoxia initiate drug tolerance to EGFR inhibitors in lung adenocarcinoma. Nature Metabolism. 2019; 1(4). View Publication.
  2. Choe J, Lin S, Zhang W, Liu Q, Wang L, Ramirez-Moya J, Du P, Kim W, Tang S, Sliz P, Santisteban P, George RE, Richards WG, Wong KK, Locker N, Slack FJ, Gregory RI. mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis. Nature. 2018 09; 561(7724):556-560. PMID: 30232453.
    Citations:    Fields:    
  3. Nagarajan MB, Tentori AM, Zhang WC, Slack FJ, Doyle PS. Nonfouling, Encoded Hydrogel Microparticles for Multiplex MicroRNA Profiling Directly from Formalin-Fixed, Paraffin-Embedded Tissue. Anal Chem. 2018 09 04; 90(17):10279-10285. PMID: 30106558.
    Citations:    Fields:    
  4. Tentori AM, Nagarajan MB, Kim JJ, Zhang WC, Slack FJ, Doyle PS. Quantitative and multiplex microRNA assays from unprocessed cells in isolated nanoliter well arrays. Lab Chip. 2018 08 07; 18(16):2410-2424. PMID: 29998262.
    Citations:    Fields:    Translation:HumansCells
  5. Zhang WC, Slack FJ. MicroRNA-21 Mediates Resistance to EGFR Tyrosine Kinase Inhibitors in Lung Cancer. Journal of Thoracic Oncology. 2017; 8(12):S1536. View Publication.
  6. Adams BD, Parsons C, Walker L, Zhang WC, Slack FJ. Targeting noncoding RNAs in disease. J Clin Invest. 2017 Mar 01; 127(3):761-771. PMID: 28248199.
    Citations: 44     Fields:    Translation:Humans
  7. Zhang WC, Slack FJ. ADARs Edit MicroRNAs to Promote Leukemic Stem Cell Activity. Cell Stem Cell. 2016 08 04; 19(2):141-142. PMID: 27494666.
    Citations:    Fields:    Translation:HumansCells
  8. Yong KJ, Basseres DS, Welner RS, Zhang WC, Yang H, Yan B, Alberich-Jorda M, Zhang J, de Figueiredo-Pontes LL, Battelli C, Hetherington CJ, Ye M, Zhang H, Maroni G, O'Brien K, Magli MC, Borczuk AC, Varticovski L, Kocher O, Zhang P, Moon YC, Sydorenko N, Cao L, Davis TW, Thakkar BM, Soo RA, Iwama A, Lim B, Halmos B, Neuberg D, Tenen DG, Levantini E. Targeted BMI1 inhibition impairs tumor growth in lung adenocarcinomas with low CEBPa expression. Sci Transl Med. 2016 08 03; 8(350):350ra104. PMID: 27488898.
    Citations: 6     Fields:    Translation:HumansAnimals
  9. Zhang WC, Chin TM, Yang H, Nga ME, Lunny DP, Lim EK, Sun LL, Pang YH, Leow YN, Malusay SR, Lim PX, Lee JZ, Tan BJ, Shyh-Chang N, Lim EH, Lim WT, Tan DS, Tan EH, Tai BC, Soo RA, Tam WL, Lim B. Tumour-initiating cell-specific miR-1246 and miR-1290 expression converge to promote non-small cell lung cancer progression. Nat Commun. 2016 06 21; 7:11702. PMID: 27325363.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  10. Bing Lim, Wencai Zhang. Targeting metabolic enzymes in human cancer. 2016. View Publication.
  11. Hoe SL, Tan LP, Jamal J, Peh SC, Ng CC, Zhang WC, Ahmad M, Khoo AS. Evaluation of stem-like side population cells in a recurrent nasopharyngeal carcinoma cell line. Cancer Cell Int. 2014; 14(1):101. PMID: 25317078.
    Citations: 7     
  12. Wen Cai Zhang, Bing Lim. Targeting metabolic enzyme with locked nucleic acids in non-small cell lung cancer. Cancer Research. 2014; 74(19 Supplem):1438-1438. View Publication.
  13. Go MK, Zhang WC, Lim B, Yew WS. Glycine decarboxylase is an unusual amino acid decarboxylase involved in tumorigenesis. Biochemistry. 2014 Feb 11; 53(5):947-56. PMID: 24467211.
    Citations: 4     Fields:    Translation:HumansCells
  14. Soh BS, Zheng D, Li Yeo JS, Yang HH, Ng SY, Wong LH, Zhang W, Li P, Nichane M, Asmat A, Wong PS, Wong PC, Su LL, Mantalaris SA, Lu J, Xian W, McKeon F, Chen J, Lim EH, Lim B. CD166(pos) subpopulation from differentiated human ES and iPS cells support repair of acute lung injury. Mol Ther. 2012 Dec; 20(12):2335-46. PMID: 22968480.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  15. Zhang WC, Shyh-Chang N, Yang H, Rai A, Umashankar S, Ma S, Soh BS, Sun LL, Tai BC, Nga ME, Bhakoo KK, Jayapal SR, Nichane M, Yu Q, Ahmed DA, Tan C, Sing WP, Tam J, Thirugananam A, Noghabi MS, Pang YH, Ang HS, Mitchell W, Robson P, Kaldis P, Soo RA, Swarup S, Lim EH, Lim B. Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis. Cell. 2012 Jan 20; 148(1-2):259-72. PMID: 22225612.
    Citations: 192     Fields:    Translation:HumansCells
  16. Wen Cai Zhang, He Yang, Boon Seng Soh, Li Li Sun, Tan Min Chin, Elaine Hsuen Lim, Bing Lim. Evidence for tumor initiating stem cells in lung cancer. Cancer Research. 2011; 71(8 Suppl):487. View Publication.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.