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Carlos G. Silva Garcia

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Biography
National Autonomous University of Mexico, MexicoPh.D.2014Biomedical Sciences
T.H. Chan Harvard School of Public Health, USAPostdocActualAging
2020 - 2025
K99/R00 Pathway to Independence Award NIA/NIH
2018 - 2019
Aramont Postdoctoral Fellowship
2016 - 2018
Yerby Postdoctoral Fellowship
2007 - 2012
Ph.D. scholarship
2007
First of the class
2007
Summa cum laude
2003 - 2007
Undergrad scholarship
2005 - 2006
Undergrad scholarship

Overview
My broad scientific interests lie in understanding genetic and non-genetic mechanisms that regulate aging and aging-related diseases. In particular, I am interested to study how molecular and cellular mechanisms of external signals that promote longevity regulate epigenetic and metabolic changes; how it impacts age-related diseases, and whether these conditions (positive or negative) can be transmitted to next generations. In the Mair lab, I study how epigenetic marks reprogram transcriptional networks to promote longevity using cutting-edge techniques such as CRISPR to develop novel approaches to study the aging process.

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Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Mkrtchyan GV, Abdelmohsen K, Andreux P, Bagdonaite I, Barzilai N, Brunak S, Cabreiro F, de Cabo R, Campisi J, Cuervo AM, Demaria M, Ewald CY, Fang EF, Faragher R, Ferrucci L, Freund A, Silva-García CG, Georgievskaya A, Gladyshev VN, Glass DJ, Gorbunova V, de Grey A, He WW, Hoeijmakers J, Hoffmann E, Horvath S, Houtkooper RH, Jensen MK, Jensen MB, Kane A, Kassem M, de Keizer P, Kennedy B, Karsenty G, Lamming DW, Lee KF, MacAulay N, Mamoshina P, Mellon J, Molenaars M, Moskalev A, Mund A, Niedernhofer L, Osborne B, Pak HH, Parkhitko A, Raimundo N, Rando TA, Rasmussen LJ, Reis C, Riedel CG, Franco-Romero A, Schumacher B, Sinclair DA, Suh Y, Taub PR, Toiber D, Treebak JT, Valenzano DR, Verdin E, Vijg J, Young S, Zhang L, Bakula D, Zhavoronkov A, Scheibye-Knudsen M. ARDD 2020: from aging mechanisms to interventions. Aging (Albany NY). 2020 12 30; 12(24):24484-24503. PMID: 33378272.
    Citations: 1     Fields:    Translation:Humans
  2. Zhang Y, Lanjuin A, Chowdhury SR, Mistry M, Silva-García CG, Weir HJ, Lee CL, Escoubas CC, Tabakovic E, Mair WB. Neuronal TORC1 modulates longevity via AMPK and cell nonautonomous regulation of mitochondrial dynamics in C. elegans. Elife. 2019 08 14; 8. PMID: 31411562.
    Citations: 14     Fields:    Translation:Animals
  3. Silva-García CG, Lanjuin A, Heintz C, Dutta S, Clark NM, Mair WB. Single-Copy Knock-In Loci for Defined Gene Expression in Caenorhabditis elegans. G3 (Bethesda). 2019 07 09; 9(7):2195-2198. PMID: 31064766.
    Citations: 6     Fields:    Translation:Animals
  4. Cantú-Quintanilla G, Gómez-Guerrero I, Silva-García CG, Valdez-Ortiz R. [Intermittent hemodialysis]. Salud Publica Mex. 2017 Jul-Aug; 59(4):491-492. PMID: 29211272.
    Citations: 1     Fields:    Translation:Humans
  5. Han S, Schroeder EA, Silva-García CG, Hebestreit K, Mair WB, Brunet A. Mono-unsaturated fatty acids link H3K4me3 modifiers to C. elegans lifespan. Nature. 2017 04 13; 544(7649):185-190. PMID: 28379943.
    Citations: 64     Fields:    Translation:AnimalsCells
  6. Escoubas CC, Silva-García CG, Mair WB. Deregulation of CRTCs in Aging and Age-Related Disease Risk. Trends Genet. 2017 05; 33(5):303-321. PMID: 28365140.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  7. Heintz C, Doktor TK, Lanjuin A, Escoubas C, Zhang Y, Weir HJ, Dutta S, Silva-García CG, Bruun GH, Morantte I, Hoxhaj G, Manning BD, Andresen BS, Mair WB. Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans. Nature. 2017 01 05; 541(7635):102-106. PMID: 27919065.
    Citations: 42     Fields:    Translation:AnimalsCells
  8. Huelgas-Morales G, Silva-García CG, Salinas LS, Greenstein D, Navarro RE. The Stress Granule RNA-Binding Protein TIAR-1 Protects Female Germ Cells from Heat Shock in Caenorhabditis elegans. G3 (Bethesda). 2016 04 07; 6(4):1031-47. PMID: 26865701.
    Citations: 12     Fields:    Translation:AnimalsCells
  9. Láscarez-Lagunas LI, Silva-García CG, Dinkova TD, Navarro RE. LIN-35/Rb causes starvation-induced germ cell apoptosis via CED-9/Bcl2 downregulation in Caenorhabditis elegans. Mol Cell Biol. 2014 Jul; 34(13):2499-516. PMID: 24752899.
    Citations: 9     Fields:    Translation:AnimalsCells
  10. Silva-García CG, Estela Navarro R. The C. elegans TIA-1/TIAR homolog TIAR-1 is required to induce germ cell apoptosis. Genesis. 2013 Oct; 51(10):690-707. PMID: 23913578.
    Citations: 7     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.