Harvard Catalyst Profiles

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Jorge Ivan Castillo-Quan, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Bjedov I, Cochemé HM, Foley A, Wieser D, Woodling NS, Castillo-Quan JI, Norvaisas P, Lujan C, Regan JC, Toivonen JM, Murphy MP, Thornton J, Kinghorn KJ, Neufeld TP, Cabreiro F, Partridge L. Fine-tuning autophagy maximises lifespan and is associated with changes in mitochondrial gene expression in Drosophila. PLoS Genet. 2020 11; 16(11):e1009083. PMID: 33253201; PMCID: PMC7738165.
    Citations: 7     Fields:    Translation:AnimalsCells
  2. Stead ER, Castillo-Quan JI, Miguel VEM, Lujan C, Ketteler R, Kinghorn KJ, Bjedov I. Agephagy - Adapting Autophagy for Health During Aging. Front Cell Dev Biol. 2019; 7:308. PMID: 31850344.
    Citations: 22     
  3. Castillo-Quan JI, Tain LS, Kinghorn KJ, Li L, Grönke S, Hinze Y, Blackwell TK, Bjedov I, Partridge L. A triple drug combination targeting components of the nutrient-sensing network maximizes longevity. Proc Natl Acad Sci U S A. 2019 10 15; 116(42):20817-20819. PMID: 31570569; PMCID: PMC6800352.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  4. Ewald CY, Castillo-Quan JI, Blackwell TK. Untangling Longevity, Dauer, and Healthspan in Caenorhabditis elegans Insulin/IGF-1-Signalling. Gerontology. 2018; 64(1):96-104. PMID: 28934747.
    Citations: 19     Fields:    Translation:AnimalsCells
  5. Kerr F, Sofola-Adesakin O, Ivanov DK, Gatliff J, Gomez Perez-Nievas B, Bertrand HC, Martinez P, Callard R, Snoeren I, Cochemé HM, Adcott J, Khericha M, Castillo-Quan JI, Wells G, Noble W, Thornton J, Partridge L. Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease. PLoS Genet. 2017 Mar; 13(3):e1006593. PMID: 28253260; PMCID: PMC5333801.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  6. Kinghorn KJ, Asghari AM, Castillo-Quan JI. The emerging role of autophagic-lysosomal dysfunction in Gaucher disease and Parkinson's disease. Neural Regen Res. 2017 Mar; 12(3):380-384. PMID: 28469644; PMCID: PMC5399707.
    Citations: 22     
  7. Castillo-Quan JI, Blackwell TK. Metformin: Restraining Nucleocytoplasmic Shuttling to Fight Cancer and Aging. Cell. 2016 12 15; 167(7):1670-1671. PMID: 27984715.
    Citations: 20     Fields:    Translation:HumansAnimals
  8. Kinghorn KJ, Grönke S, Castillo-Quan JI, Woodling NS, Li L, Sirka E, Gegg M, Mills K, Hardy J, Bjedov I, Partridge L. A Drosophila Model of Neuronopathic Gaucher Disease Demonstrates Lysosomal-Autophagic Defects and Altered mTOR Signalling and Is Functionally Rescued by Rapamycin. J Neurosci. 2016 11 16; 36(46):11654-11670. PMID: 27852774; PMCID: PMC5125225.
    Citations: 49     Fields:    Translation:AnimalsCells
  9. Kinghorn KJ, Castillo-Quan JI, Li L, Bhatia KP, Abramov AY, Hardy J, Partridge L. Reply: Glial mitochondropathy in infantile neuroaxonal dystrophy: pathophysiological and therapeutic implications. Brain. 2016 12; 139(Pt 12):e68. PMID: 27497489.
    Citations:    Fields:    Translation:HumansCells
  10. Castillo-Quan JI, Li L, Kinghorn KJ, Ivanov DK, Tain LS, Slack C, Kerr F, Nespital T, Thornton J, Hardy J, Bjedov I, Partridge L. Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis. Cell Rep. 2016 Apr 19; 15(3):638-650. PMID: 27068460; PMCID: PMC4850359.
    Citations: 79     Fields:    Translation:AnimalsCells
  11. Kinghorn KJ, Castillo-Quan JI. Mitochondrial dysfunction and defects in lipid homeostasis as therapeutic targets in neurodegeneration with brain iron accumulation. Rare Dis. 2016; 4(1):e1128616. PMID: 27141409; PMCID: PMC4838319.
    Citations: 6     
  12. Castillo-Quan JI, Kinghorn KJ, Bjedov I. Genetics and pharmacology of longevity: the road to therapeutics for healthy aging. Adv Genet. 2015; 90:1-101. PMID: 26296933.
    Citations: 14     Fields:    Translation:HumansAnimals
  13. Kinghorn KJ, Castillo-Quan JI, Bartolome F, Angelova PR, Li L, Pope S, Cochemé HM, Khan S, Asghari S, Bhatia KP, Hardy J, Abramov AY, Partridge L. Loss of PLA2G6 leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction. Brain. 2015 Jul; 138(Pt 7):1801-16. PMID: 26001724; PMCID: PMC4559908.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  14. Sofola-Adesakin O, Castillo-Quan JI, Rallis C, Tain LS, Bjedov I, Rogers I, Li L, Martinez P, Khericha M, Cabecinha M, Bähler J, Partridge L. Lithium suppresses Aß pathology by inhibiting translation in an adult Drosophila model of Alzheimer's disease. Front Aging Neurosci. 2014; 6:190. PMID: 25126078; PMCID: PMC4115666.
    Citations: 27     
  15. Castillo-Quan JI, Kinghorn KJ. [Molecular gerontology: towards healthy aging]. Gac Med Mex. 2013 Nov-Dec; 149(6):680-5. PMID: 24276192.
    Citations:    Fields:    Translation:Humans
  16. Castillo-Quan JI. From white to brown fat through the PGC-1a-dependent myokine irisin: implications for diabetes and obesity. Dis Model Mech. 2012 May; 5(3):293-5. PMID: 22566556.
    Citations: 47     Fields:    Translation:Animals
  17. Castillo-Quan JI. Parkin' control: regulation of PGC-1a through PARIS in Parkinson's disease. Dis Model Mech. 2011 Jul; 4(4):427-9. PMID: 21708898.
    Citations: 13     Fields:    Translation:HumansAnimals
  18. Castillo-Quan JI, Barrera-Buenfil DJ, Pérez-Osorio JM, Alvarez-Cervera FJ. [Depression and diabetes: from epidemiology to neurobiology]. Rev Neurol. 2010 Sep 16; 51(6):347-59. PMID: 20839171.
    Citations: 6     Fields:    Translation:HumansAnimals
  19. Castillo-Quan JI, Pérez-Osorio JM. [Alzheimer's disease and methylenetetrahydrofolate reductase gene polymorphisms: a potential nutrigenomic approach for Mexico]. Gac Med Mex. 2009 Mar-Apr; 145(2):147-50. PMID: 19518022.
    Citations:    Fields:    Translation:Humans
  20. Castillo-Quan JI. Rosiglitazone effects to ameliorate Alzheimer's disease pathogenic features: insulin signaling and neurotrophic factors. J Neuropsychiatry Clin Neurosci. 2009; 21(3):347-8. PMID: 19776322.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  21. Xacur-García F, Castillo-Quan JI, Hernández-Escalante VM, Laviada-Molina H. [Nutritional genomics: an approach to the genome-environment interaction]. Rev Med Chil. 2008 Nov; 136(11):1460-7. PMID: 19301779.
    Citations:    Fields:    Translation:Humans
  22. Castillo-Quan JI. Insulin resistance, hypercortisolism, polycystic ovarian syndrome, and depression--nonrandom associations? Fertil Steril. 2008 Apr; 89(4):1029-30; author reply 1030. PMID: 18325512.
    Citations:    Fields:    Translation:Humans
  23. Castillo-Quan JI, Herrera-González A, Pérez-Osorio JM. Insulin-cortisol interaction in depression and other neurological diseases: an alternative hypothesis. Psychoneuroendocrinology. 2007 Aug; 32(7):854-5; author reply 856. PMID: 17574343.
    Citations: 1     Fields:    Translation:Humans
  24. Castillo-Quan JI, Pérez-Osorio JM. Cortisol secretion in patients with type 2 diabetes: relationship with chronic complications: response to Chiodini et al. Diabetes Care. 2007 Jun; 30(6):e49; author reply e50. PMID: 17526811.
    Citations: 1     Fields:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.