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Jorge Ivan Castillo-Quan, Ph.D.

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  1. Ewald CY, Castillo-Quan JI, Blackwell TK. Untangling Longevity, Dauer, and Healthspan in Caenorhabditis elegans Insulin/IGF-1-Signalling. Gerontology. 2018; 64(1):96-104. PMID: 28934747.
    View in: PubMed
  2. Kerr F, Sofola-Adesakin O, Ivanov DK, Gatliff J, Gomez Perez-Nievas B, Bertrand HC, Martinez P, Callard R, Snoeren I, Cochemé HM, Adcott J, Khericha M, Castillo-Quan JI, Wells G, Noble W, Thornton J, Partridge L. Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease. PLoS Genet. 2017 Mar; 13(3):e1006593. PMID: 28253260.
    View in: PubMed
  3. Kinghorn KJ, Asghari AM, Castillo-Quan JI. The emerging role of autophagic-lysosomal dysfunction in Gaucher disease and Parkinson's disease. Neural Regen Res. 2017 Mar; 12(3):380-384. PMID: 28469644.
    View in: PubMed
  4. Castillo-Quan JI, Blackwell TK. Metformin: Restraining Nucleocytoplasmic Shuttling to Fight Cancer and Aging. Cell. 2016 12 15; 167(7):1670-1671. PMID: 27984715.
    View in: PubMed
  5. Kinghorn KJ, Grönke S, Castillo-Quan JI, Woodling NS, Li L, Sirka E, Gegg M, Mills K, Hardy J, Bjedov I, Partridge L. A Drosophila Model of Neuronopathic Gaucher Disease Demonstrates Lysosomal-Autophagic Defects and Altered mTOR Signalling and Is Functionally Rescued by Rapamycin. J Neurosci. 2016 11 16; 36(46):11654-11670. PMID: 27852774.
    View in: PubMed
  6. Kinghorn KJ, Castillo-Quan JI, Li L, Bhatia KP, Abramov AY, Hardy J, Partridge L. Reply: Glial mitochondropathy in infantile neuroaxonal dystrophy: pathophysiological and therapeutic implications. Brain. 2016 12; 139(Pt 12):e68. PMID: 27497489.
    View in: PubMed
  7. Castillo-Quan JI, Li L, Kinghorn KJ, Ivanov DK, Tain LS, Slack C, Kerr F, Nespital T, Thornton J, Hardy J, Bjedov I, Partridge L. Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis. Cell Rep. 2016 Apr 19; 15(3):638-650. PMID: 27068460; PMCID: PMC4850359.
  8. Kinghorn KJ, Castillo-Quan JI. Mitochondrial dysfunction and defects in lipid homeostasis as therapeutic targets in neurodegeneration with brain iron accumulation. Rare Dis. 2016; 4(1):e1128616. PMID: 27141409; PMCID: PMC4838319.
  9. Castillo-Quan JI, Kinghorn KJ, Bjedov I. Genetics and pharmacology of longevity: the road to therapeutics for healthy aging. Adv Genet. 2015; 90:1-101. PMID: 26296933.
    View in: PubMed
  10. Kinghorn KJ, Castillo-Quan JI, Bartolome F, Angelova PR, Li L, Pope S, Cochemé HM, Khan S, Asghari S, Bhatia KP, Hardy J, Abramov AY, Partridge L. Loss of PLA2G6 leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction. Brain. 2015 Jul; 138(Pt 7):1801-16. PMID: 26001724.
    View in: PubMed
  11. Sofola-Adesakin O, Castillo-Quan JI, Rallis C, Tain LS, Bjedov I, Rogers I, Li L, Martinez P, Khericha M, Cabecinha M, Bähler J, Partridge L. Lithium suppresses Aß pathology by inhibiting translation in an adult Drosophila model of Alzheimer's disease. Front Aging Neurosci. 2014; 6:190. PMID: 25126078.
    View in: PubMed
  12. Castillo-Quan JI, Kinghorn KJ. [Molecular gerontology: towards healthy aging]. Gac Med Mex. 2013 Nov-Dec; 149(6):680-5. PMID: 24276192.
    View in: PubMed
  13. Castillo-Quan JI. From white to brown fat through the PGC-1a-dependent myokine irisin: implications for diabetes and obesity. Dis Model Mech. 2012 May; 5(3):293-5. PMID: 22566556; PMCID: PMC3339822.
  14. Castillo-Quan JI. Parkin' control: regulation of PGC-1a through PARIS in Parkinson's disease. Dis Model Mech. 2011 Jul; 4(4):427-9. PMID: 21708898; PMCID: PMC3124045.
  15. Castillo-Quan JI, Barrera-Buenfil DJ, Pérez-Osorio JM, Alvarez-Cervera FJ. [Depression and diabetes: from epidemiology to neurobiology]. Rev Neurol. 2010 Sep 16; 51(6):347-59. PMID: 20839171.
    View in: PubMed
  16. Castillo-Quan JI, Pérez-Osorio JM. [Alzheimer's disease and methylenetetrahydrofolate reductase gene polymorphisms: a potential nutrigenomic approach for Mexico]. Gac Med Mex. 2009 Mar-Apr; 145(2):147-50. PMID: 19518022.
    View in: PubMed
  17. Castillo-Quan JI. Rosiglitazone effects to ameliorate Alzheimer's disease pathogenic features: insulin signaling and neurotrophic factors. J Neuropsychiatry Clin Neurosci. 2009; 21(3):347-8. PMID: 19776322.
    View in: PubMed
  18. Xacur-García F, Castillo-Quan JI, Hernández-Escalante VM, Laviada-Molina H. [Nutritional genomics: an approach to the genome-environment interaction]. Rev Med Chil. 2008 Nov; 136(11):1460-7. PMID: 19301779.
    View in: PubMed
  19. Castillo-Quan JI. Insulin resistance, hypercortisolism, polycystic ovarian syndrome, and depression--nonrandom associations? Fertil Steril. 2008 Apr; 89(4):1029-30; author reply 1030. PMID: 18325512.
    View in: PubMed
  20. Castillo-Quan JI, Herrera-González A, Pérez-Osorio JM. Insulin-cortisol interaction in depression and other neurological diseases: an alternative hypothesis. Psychoneuroendocrinology. 2007 Aug; 32(7):854-5; author reply 856. PMID: 17574343.
    View in: PubMed
  21. Castillo-Quan JI, Pérez-Osorio JM. Cortisol secretion in patients with type 2 diabetes: relationship with chronic complications: response to Chiodini et al. Diabetes Care. 2007 Jun; 30(6):e49; author reply e50. PMID: 17526811.
    View in: PubMed
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