Harvard Catalyst Profiles

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Xudong Huang, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AG056614 (HUANG, XUDONG) Aug 1, 2017 - Mar 31, 2021
    NIH/NIA
    Nanoneurotoxicity of Metal Oxide Nanomaterials and Neurodegeneration
    Role: Principal Investigator
  2. R21AG028850 (HUANG, XUDONG) Aug 1, 2007 - May 31, 2010
    NIH/NIA
    Lipoate Derivatives Targeting Alzheimer's Amyloid
    Role: Principal Investigator
  3. K01MH002001 (HUANG, XUDONG) Feb 1, 2001 - Jan 31, 2007
    NIH/NIMH
    BIOMETALS, OXIDATIVE STRESS, AND AB AMYLOIDOSIS
    Role: Principal Investigator
  4. F32AG005782 (HUANG, XUDONG) Mar 27, 1996
    NIH/NIA
    ZINC AND ALZHEIMERS AMYLOID CHEMISTRY
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Carpenter K, Pilozzi A, Huang X. A Pilot Study of Multi-Input Recurrent Neural Networks for Drug-Kinase Binding Prediction. Molecules. 2020 Jul 24; 25(15). PMID: 32722290.
    Citations:    
  2. Tam J, Pilozzi A, Mahmood U, Huang X. Simultaneous Monitoring of Multi-Enzyme Activity and Concentration in Tumor Using a Triply Labeled Fluorescent In Vivo Imaging Probe. Int J Mol Sci. 2020 Apr 27; 21(9). PMID: 32349205.
    Citations:    
  3. Koutentakis D, Pilozzi A, Huang X. Designing Socially Assistive Robots for Alzheimer's Disease and Related Dementia Patients and Their Caregivers: Where We are and Where We are Headed. Healthcare (Basel). 2020 Mar 26; 8(2). PMID: 32225117.
    Citations:    
  4. Pilozzi A, Huang X. Overcoming Alzheimer's Disease Stigma by Leveraging Artificial Intelligence and Blockchain Technologies. Brain Sci. 2020 Mar 23; 10(3). PMID: 32210011.
    Citations:    
  5. Pilozzi A, Yu Z, Carreras I, Cormier K, Hartley D, Rogers J, Dedeoglu A, Huang X. A Preliminary Study of Cu Exposure Effects upon Alzheimer's Amyloid Pathology. Biomolecules. 2020 03 06; 10(3). PMID: 32155778.
    Citations:    
  6. Mou X, Pilozzi A, Tailor B, Yi J, Cahill C, Rogers J, Huang X. Exposure to CuO Nanoparticles Mediates NF?B Activation and Enhances Amyloid Precursor Protein Expression. Biomedicines. 2020 Feb 27; 8(3). PMID: 32120908.
    Citations:    
  7. Shi Y, Pilozzi AR, Huang X. Exposure of CuO Nanoparticles Contributes to Cellular Apoptosis, Redox Stress, and Alzheimer's Aß Amyloidosis. Int J Environ Res Public Health. 2020 02 05; 17(3). PMID: 32033400.
    Citations:    
  8. Tam JM, Josephson L, Pilozzi AR, Huang X. A Novel Dual Fluorochrome Near-Infrared Imaging Probe for Potential Alzheimer's Enzyme Biomarkers-BACE1 and Cathepsin D. Molecules. 2020 Jan 09; 25(2). PMID: 31936569.
    Citations:    
  9. Cohen D, Pilozzi A, Huang X. Network Medicine Approach for Analysis of Alzheimer's Disease Gene Expression Data. Int J Mol Sci. 2020 Jan 03; 21(1). PMID: 31947790.
    Citations:    
  10. Tailor B, Pilozzi A, Huang X. In: Wisniewski T, editor. Alzheimer’s Disease. Contributing Factors of Neurodegeneration in Alzheimer’s Disease. 2019; 69-84. View Publication.
  11. Carro CE, Pilozzi AR, Huang X. Nanoneurotoxicity and Potential Nanotheranostics for Alzheimer's Disease. EC Pharmacol Toxicol. 2019 Dec; 7(12):1-7. PMID: 31828253.
    Citations:    
  12. Cohen DS, Carpenter KA, Jarrell JT, Huang X. Deep learning-based classification of multi-categorical Alzheimer's disease data. Curr Neurobiol. 2019 Oct; 10(3):141-147. PMID: 31798274.
    Citations:    
  13. Kisby B, Jarrell JT, Agar ME, Cohen DS, Rosin ER, Cahill CM, Rogers JT, Huang X. Alzheimer's Disease and Its Potential Alternative Therapeutics. J Alzheimers Dis Parkinsonism. 2019; 9(5). PMID: 31588368.
    Citations:    
  14. Chen HS, Jarrell JT, Carpenter KA, Cohen DS, Huang X. Blockchain in Healthcare: A Patient-Centered Model. Biomed J Sci Tech Res. 2019; 20(3):15017-15022. PMID: 31565696.
    Citations:    
  15. Wang WT, Tailor BA, Cohen DS, Huang X. Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics. EC Pharmacol Toxicol. 2019 Jul; 7(7):547-558. PMID: 31565701.
    Citations:    
  16. Pang C, Yang H, Hu B, Wang S, Chen M, Cohen DS, Chen HS, Jarrell JT, Carpenter KA, Rosin ER, Huang X. Identification and Analysis of Alzheimer's Candidate Genes by an Amplitude Deviation Algorithm. J Alzheimers Dis Parkinsonism. 2019; 9(1). PMID: 31080696.
    Citations:    
  17. Strunz M, Jarrell JT, Cohen DS, Rosin ER, Vanderburg CR, Huang X. Modulation of SPARC/Hevin Proteins in Alzheimer's Disease Brain Injury. J Alzheimers Dis. 2019; 68(2):695-710. PMID: 30883351.
    Citations:    
  18. Venkataramani V, Doeppner TR, Willkommen D, Cahill CM, Xin Y, Ye G, Liu Y, Southon A, Aron A, Au-Yeung HY, Huang X, Lahiri DK, Wang F, Bush AI, Wulf GG, Ströbel P, Michalke B, Rogers JT. Manganese causes neurotoxic iron accumulation via translational repression of amyloid precursor protein and H-Ferritin. J Neurochem. 2018 12; 147(6):831-848. PMID: 30152072.
    Citations:    Fields:    
  19. Chen H, Huang X. Will Blockchain Technology Transform Healthcare and Biomedical Sciences? EC Pharmacol Toxicol. 2018 Nov; 6(11):910-911. PMID: 31460519.
    Citations:    
  20. Carpenter KA, Cohen DS, Jarrell JT, Huang X. Deep learning and virtual drug screening. Future Med Chem. 2018 11; 10(21):2557-2567. PMID: 30288997.
    Citations:    Fields:    
  21. Rogers JT, Huang X, Spoonamore J. Amyloid Precursor Protein mRNA blockers for treating Down syndrome and Alzheimer’s disease. 2018.
  22. Jarrell JT, Gao L, Cohen DS, Huang X. Network Medicine for Alzheimer's Disease and Traditional Chinese Medicine. Molecules. 2018 05 11; 23(5). PMID: 29751596.
    Citations:    Fields:    Translation:HumansCells
  23. Gao L, Li J, Zhou Y, Huang X, Qin X, Du G. Effects of Baicalein on Cortical Proinflammatory Cytokines and the Intestinal Microbiome in Senescence Accelerated Mouse Prone 8. ACS Chem Neurosci. 2018 07 18; 9(7):1714-1724. PMID: 29668250.
    Citations: 1     Fields:    
  24. Gao J, Cahill CM, Huang X, Roffman JL, Lamon-Fava S, Fava M, Mischoulon D, Rogers JT. S-Adenosyl Methionine and Transmethylation Pathways in Neuropsychiatric Diseases Throughout Life. Neurotherapeutics. 2018 01; 15(1):156-175. PMID: 29340929.
    Citations:    Fields:    
  25. Carpenter KA, Huang X. Machine Learning-based Virtual Screening and Its Applications to Alzheimer's Drug Discovery: A Review. Curr Pharm Des. 2018; 24(28):3347-3358. PMID: 29879881.
    Citations:    Fields:    
  26. Yang W, Chen X, Cohen DS, Rosin ER, Toga AW, Thompson PM, Huang X. Classification of MRI and psychological testing data based on support vector machine. Int J Clin Exp Med. 2017 Dec; 10(12):16004-16026. PMID: 29445429.
    Citations:    
  27. Carpenter K, Huang X. Is it a Prime Time for AI-powered Virtual Drug Screening? EC Pharmacol Toxicol. 2017; SI(1):16-17. PMID: 30215059.
    Citations:    
  28. Patel AK, Patel KK, Ratai E-M, Huang X. Neuroblastoma: Current Imaging and Therapeutics. Journal of Cancer and Tumor International. 2015; 2(3):89-109.
  29. Hu B, Huang X, Zhou R, Wei Y, Wan Q, Pang C. A theoretical framework for quantum image representation and data loading scheme. Science China Information Sciences. 2014; 57(3):1-11.
  30. Zhao W, Liu Y, Huang X. Enhancement of bone formation by bone morphogenetic protein-2 released from poly(l-lactic-co-glycolic acid) microsphere. British Biotechnology Journal. 2014; 4:1223-1237.
  31. Patel AK, Zhang M, Huang X. British Journal of Medicine & Medical Research. Leukemia Therapy: Mechanisms of Drug Resistance and Investigational Strategies. 2014; 4 :4134-53.
  32. Huang X, Rogers JT, Vanderburg CR, Lai B, Dedeoglu A. Biochemistry & Pharmacology. Metal exposure and Alzheimer’s pathophysiology. 2014; 3:e156.
  33. Bandyopadhyay S, Cahill C, Balleidier A, Huang C, Lahiri DK, Huang X, Rogers JT. Novel 5' untranslated region directed blockers of iron-regulatory protein-1 dependent amyloid precursor protein translation: implications for down syndrome and Alzheimer's disease. PLoS One. 2013; 8(7):e65978. PMID: 23935819.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  34. Huang H, Chen Z, Huang X. Age-adjusted nonparametric detection of differential DNA methylation with case-control designs. BMC Bioinformatics. 2013 Mar 06; 14:86. PMID: 23497201.
    Citations: 7     Fields:    Translation:HumansCells
  35. Chen Z, Huang H, Liu J, Tony Ng HK, Nadarajah S, Huang X, Deng Y. Detecting differentially methylated loci for Illumina Array methylation data based on human ovarian cancer data. BMC Med Genomics. 2013; 6 Suppl 1:S9. PMID: 23369576.
    Citations: 8     Fields:    Translation:HumansCells
  36. Hu B, Jiang G, Pang C, Wang S, Liu Q, Chen Z, Vanderburg CR, Rogers JT, Deng Y, Huang X. Assessment of gene order computing methods for Alzheimer's disease. BMC Med Genomics. 2013; 6 Suppl 1:S8. PMID: 23369541.
    Citations: 1     Fields:    Translation:Humans
  37. Huang X. Biochemistry & Pharmacology. Exposure of Engineered Nanomaterials and its potential contribution to Alzheimer’s pathophysiology. 2013; 2:e144.
  38. Zhao W, Zheng X, Liu Y, Yang W, Amirbekian V, Diaz LE, Huang X. An MRI study of symptomatic adhesive capsulitis. PLoS One. 2012; 7(10):e47277. PMID: 23082152.
    Citations: 8     Fields:    Translation:Humans
  39. Olivares D, Deshpande VK, Shi Y, Lahiri DK, Greig NH, Rogers JT, Huang X. N-methyl D-aspartate (NMDA) receptor antagonists and memantine treatment for Alzheimer's disease, vascular dementia and Parkinson's disease. Curr Alzheimer Res. 2012 Jul; 9(6):746-58. PMID: 21875407.
    Citations: 37     Fields:    Translation:HumansAnimals
  40. Shaikh MA and Huang X. Green Solvents II: Properties and Applications of Ionic Liquids (Mohammad A., Inamuddin J., editors). Organic ionic liquids: ultimate green solvent in organic synthesis. 2012; 561-89.
  41. Pang C, Jiang G, Wang S, Hu B, Liu Q, Deng Y, Huang X. Gene order computation using Alzheimer's DNA microarray gene expression data and the Ant Colony Optimisation algorithm. Int J Data Min Bioinform. 2012; 6(6):617-32. PMID: 23356011.
    Citations: 2     Fields:    Translation:Humans
  42. Lang H, Huang X, Yang Y. Identification of putative molecular imaging probes for BACE-1 by accounting for protein flexibility in virtual screening. J Alzheimers Dis. 2012; 29(2):351-9. PMID: 22232010.
    Citations:    Fields:    Translation:HumansCells
  43. Liu Q, Sung AH, Chen Z, Liu J, Chen L, Qiao M, Wang Z, Huang X, Deng Y. Gene selection and classification for cancer microarray data based on machine learning and similarity measures. BMC Genomics. 2011 Dec 23; 12 Suppl 5:S1. PMID: 22369383.
    Citations: 16     Fields:    Translation:Humans
  44. Chen Z, Liu Q, McGee M, Kong M, Huang X, Deng Y, Scheuermann RH. A gene selection method for GeneChip array data with small sample sizes. BMC Genomics. 2011 Dec 23; 12 Suppl 5:S7. PMID: 22369149.
    Citations: 3     Fields:    
  45. Chen Z, McGee M, Liu Q, Kong YM, Huang X, Yang JY, Scheuermann RH. Identifying Differentially Expressed Genes based on probe level data for GeneChip arrays. Int J Comput Biol Drug Des. 2010; 3(3):237-57. PMID: 21228458.
    Citations: 3     Fields:    
  46. Rogers JT, Mikkilineni S, Cantuti-Castelvetri I, Smith DH, Huang X, Bandyopadhyay S, Cahill CM, Maccecchini ML, Lahiri DK, Greig NH. The alpha-synuclein 5'untranslated region targeted translation blockers: anti-alpha synuclein efficacy of cardiac glycosides and Posiphen. J Neural Transm (Vienna). 2011 Mar; 118(3):493-507. PMID: 21221670.
    Citations: 17     Fields:    Translation:HumansCells
  47. Yang W, Lui RL, Gao JH, Chan TF, Yau ST, Sperling RA, Huang X. Independent component analysis-based classification of Alzheimer's disease MRI data. J Alzheimers Dis. 2011; 24(4):775-83. PMID: 21321398.
    Citations: 9     Fields:    Translation:Humans
  48. Mou X, Kesari S, Wen PY, Huang X. Crude drugs as anticancer agents. Int J Clin Exp Med. 2011; 4(1):17-25. PMID: 21394282.
    Citations: 3     
  49. Bandyopadhyay S, Huang X, Lahiri DK, Rogers JT. Novel drug targets based on metallobiology of Alzheimer's disease. Expert Opin Ther Targets. 2010 Nov; 14(11):1177-97. PMID: 20942746.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  50. Royce-Nagel G, Cudkowicz M, Myers D, Nicholson K, Shui A, Schoenfeld D, Huang X, Brown RH. Vanadium, aluminum, magnesium and manganese are not elevated in hair samples in amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2010 Oct; 11(5):492-3. PMID: 20438306.
    Citations:    Fields:    Translation:HumansPHPublic Health
  51. Lisitza N, Huang X, Hatabu H, Patz S. Exploring collagen self-assembly by NMR. Phys Chem Chem Phys. 2010 Nov 14; 12(42):14169-71. PMID: 20877840.
    Citations:    Fields:    Translation:Cells
  52. Cho HH, Cahill CM, Vanderburg CR, Scherzer CR, Wang B, Huang X, Rogers JT. Selective translational control of the Alzheimer amyloid precursor protein transcript by iron regulatory protein-1. J Biol Chem. 2010 Oct 08; 285(41):31217-32. PMID: 20558735.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  53. Zeng Q, Yang Z, Gao YJ, Yuan H, Cui K, Shi Y, Wang H, Huang X, Wong ST, Wang Y, Kesari S, Ji RR, Xu X. Treating triple-negative breast cancer by a combination of rapamycin and cyclophosphamide: an in vivo bioluminescence imaging study. Eur J Cancer. 2010 Apr; 46(6):1132-43. PMID: 20156674.
    Citations: 11     Fields:    Translation:AnimalsCells
  54. Pang CY, Hu W, Hu BQ, Shi Y, Vanderburg CR, Rogers JT, Huang X. A special local clustering algorithm for identifying the genes associated with Alzheimer's disease. IEEE Trans Nanobioscience. 2010 Mar; 9(1):44-50. PMID: 20089478.
    Citations: 1     Fields:    Translation:Humans
  55. Liu Q, Sung AH, Chen Z, Liu J, Huang X, Deng Y. Feature selection and classification of MAQC-II breast cancer and multiple myeloma microarray gene expression data. PLoS One. 2009 Dec 11; 4(12):e8250. PMID: 20011240.
    Citations: 12     Fields:    Translation:Humans
  56. Liu Q, Sung AH, Qiao M, Chen Z, Yang JY, Yang MQ, Huang X, Deng Y. Comparison of feature selection and classification for MALDI-MS data. BMC Genomics. 2009 Jul 07; 10 Suppl 1:S3. PMID: 19594880.
    Citations: 8     Fields:    
  57. Zhao W, Liu Y, Cahill CM, Yang W, Rogers JT, Huang X. The role of T cells in osteoporosis, an update. Int J Clin Exp Pathol. 2009 May 20; 2(6):544-52. PMID: 19636401.
    Citations: 7     Fields:    
  58. Olivares D, Huang X, Branden L, Greig NH, Rogers JT. Physiological and pathological role of alpha-synuclein in Parkinson's disease through iron mediated oxidative stress; the role of a putative iron-responsive element. Int J Mol Sci. 2009 Mar; 10(3):1226-60. PMID: 19399246.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  59. Kong W, Mou X, Liu Q, Chen Z, Vanderburg CR, Rogers JT, Huang X. Independent component analysis of Alzheimer's DNA microarray gene expression data. Mol Neurodegener. 2009 Jan 28; 4:5. PMID: 19173745.
    Citations: 17     Fields:    
  60. Abid M, Torok B, Huang X. Australian Journal of Chemistry. Microwave-assisted tandem processes for the synthesis of N-heterocycles. 2009; 62:1-15.
  61. Dai Y-M, Tang E, Huang J-F, Yao Y-G, Huang X. Hydrothermal syntheses and characterizations of two eight-connected networks in a mixed ligand system. Journal of Molecular Structure. 2009; 918:183-18.
  62. Kulkarni A, Abid M, Torok B, Huang X. A direct synthesis of ß-carbolines via a three-step one-pot domino approach with a bifunctional Pd/C/K-10 catalyst. Tetrahedron Letters. 2009; 50:1791-1794.
  63. Cahill CM, Lahiri DK, Huang X, Rogers JT. Amyloid precursor protein and alpha synuclein translation, implications for iron and inflammation in neurodegenerative diseases. Biochim Biophys Acta. 2009 Jul; 1790(7):615-28. PMID: 19166904.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  64. Rogers JT, Bush AI, Cho HH, Smith DH, Thomson AM, Friedlich AL, Lahiri DK, Leedman PJ, Huang X, Cahill CM. Iron and the translation of the amyloid precursor protein (APP) and ferritin mRNAs: riboregulation against neural oxidative damage in Alzheimer's disease. Biochem Soc Trans. 2008 Dec; 36(Pt 6):1282-7. PMID: 19021541.
    Citations: 30     Fields:    Translation:HumansCells
  65. Kong W, Vanderburg CR, Gunshin H, Rogers JT, Huang X. A review of independent component analysis application to microarray gene expression data. Biotechniques. 2008 Nov; 45(5):501-20. PMID: 19007336.
    Citations: 20     Fields:    Translation:HumansCells
  66. Yi J, Horky LL, Friedlich AL, Shi Y, Rogers JT, Huang X. L-arginine and Alzheimer's disease. Int J Clin Exp Pathol. 2009; 2(3):211-38. PMID: 19079617.
    Citations: 13     Fields:    
  67. Pan Y, Huang X. Epithelial ovarian cancer stem cells-a review. Int J Clin Exp Med. 2008; 1(3):260-6. PMID: 19079661.
    Citations: 5     
  68. Patel AK, Rogers JT, Huang X. Flavanols, mild cognitive impairment, and Alzheimer's dementia. Int J Clin Exp Med. 2008; 1(2):181-91. PMID: 19079672.
    Citations: 5     
  69. Liu Q, Yang J, Chen Z, Yang MQ, Sung AH, Huang X. Supervised learning-based tagSNP selection for genome-wide disease classifications. BMC Genomics. 2008; 9 Suppl 1:S6. PMID: 18366619.
    Citations: 5     Fields:    Translation:Humans
  70. Yang JY, Yang MQ, Dunker AK, Deng Y, Huang X. Investigation of transmembrane proteins using a computational approach. BMC Genomics. 2008; 9 Suppl 1:S7. PMID: 18366620.
    Citations: 10     Fields:    Translation:Cells
  71. Yang JY, Yang MQ, Luo Z, Ma Y, Li J, Deng Y, Huang X. A hybrid machine learning-based method for classifying the Cushing's Syndrome with comorbid adrenocortical lesions. BMC Genomics. 2008; 9 Suppl 1:S23. PMID: 18366613.
    Citations: 3     Fields:    Translation:Humans
  72. Chen J, Zhu J, Cho H-H, Cui K, Li F, Zhou X, Rogers JT, Wong STC, Huang X. Differential cytotoxicity of metal oxide nanoparticles. Journal of Experimental Nanoscience. 2008; 3:321-328.
  73. Fydrych A, Moir RD, Huang C, Shi Y, Rogers JT, Huang X. Current Bioactive Compounds. Amyloid-targeted metal chelation, anti-oxidative stress, and anti-inflammation as potential Alzheimer’s therapies. 2008; 4:140-149.
  74. Li F, Zhou X, Zhu J, Ma J, Huang X, Wong ST. High content image analysis for human H4 neuroglioma cells exposed to CuO nanoparticles. BMC Biotechnol. 2007 Oct 09; 7:66. PMID: 17925027.
    Citations: 7     Fields:    Translation:HumansCells
  75. Wang J, Huang X, Huang W. A quantitative kinetic model for ATP-induced intracellular Ca2+ oscillations. J Theor Biol. 2007 Apr 07; 245(3):510-9. PMID: 17188305.
    Citations: 3     Fields:    Translation:AnimalsCells
  76. Tang E, Dai YM, Zhang J, Li ZJ, Yao YG, Zhang J, Huang XD. Two cobalt(II) 5-aminoisophthalate complexes and their stable supramolecular microporous frameworks. Inorg Chem. 2006 Aug 07; 45(16):6276-81. PMID: 16878937.
    Citations: 1     Fields:    
  77. Tucker S, Ahl M, Cho HH, Bandyopadhyay S, Cuny GD, Bush AI, Goldstein LE, Westaway D, Huang X, Rogers JT. RNA therapeutics directed to the non coding regions of APP mRNA, in vivo anti-amyloid efficacy of paroxetine, erythromycin, and N-acetyl cysteine. Curr Alzheimer Res. 2006 Jul; 3(3):221-7. PMID: 16842099.
    Citations: 18     Fields:    Translation:AnimalsCells
  78. Bush AI, Huang X, Atwood CS, Tanzi RE. Composition comprising a metal chelator and a method of treating amyloidosis. 2006.
  79. Liu G, Huang W, Moir RD, Vanderburg CR, Lai B, Peng Z, Tanzi RE, Rogers JT, Huang X. Metal exposure and Alzheimer's pathogenesis. J Struct Biol. 2006 Jul; 155(1):45-51. PMID: 16503166.
    Citations: 21     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  80. Bandyopadhyay S, Huang X, Cho H, Greig NH, Youdim MB, Rogers JT. Metal specificity of an iron-responsive element in Alzheimer's APP mRNA 5'untranslated region, tolerance of SH-SY5Y and H4 neural cells to desferrioxamine, clioquinol, VK-28, and a piperazine chelator. J Neural Transm Suppl. 2006; (71):237-47. PMID: 17447434.
    Citations: 12     Fields:    Translation:HumansCells
  81. Tucker S, Ahl M, Bush A, Westaway D, Huang X, Rogers JT. Pilot study of the reducing effect on amyloidosis in vivo by three FDA pre-approved drugs via the Alzheimer's APP 5' untranslated region. Curr Alzheimer Res. 2005 Apr; 2(2):249-54. PMID: 15974925.
    Citations: 16     Fields:    Translation:Animals
  82. Dai Y, Ma E, Tang E, Zhang J, Li Z, Huang X, Yao Y. Paratactic assembly of two distinct units into a unique 3D architecture. Crystal Growth & Design. 2005; 5:1313-15.
  83. Huang X, Atwood CS, Moir RD, Hartshorn MA, Tanzi RE, Bush AI. Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer's Abeta peptides. J Biol Inorg Chem. 2004 Dec; 9(8):954-60. PMID: 15578276.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  84. Dedeoglu A, Cormier K, Payton S, Tseitlin KA, Kremsky JN, Lai L, Li X, Moir RD, Tanzi RE, Bush AI, Kowall NW, Rogers JT, Huang X. Preliminary studies of a novel bifunctional metal chelator targeting Alzheimer's amyloidogenesis. Exp Gerontol. 2004 Nov-Dec; 39(11-12):1641-9. PMID: 15582280.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  85. Huang X, Moir RD, Tanzi RE, Bush AI, Rogers JT. Redox-active metals, oxidative stress, and Alzheimer's disease pathology. Ann N Y Acad Sci. 2004 Mar; 1012:153-63. PMID: 15105262.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  86. White AR, Barnham KJ, Huang X, Voltakis I, Beyreuther K, Masters CL, Cherny RA, Bush AI, Cappai R. Iron inhibits neurotoxicity induced by trace copper and biological reductants. J Biol Inorg Chem. 2004 Apr; 9(3):269-80. PMID: 14758525.
    Citations: 4     Fields:    Translation:AnimalsCells
  87. Atwood CS, Perry G, Zeng H, Kato Y, Jones WD, Ling KQ, Huang X, Moir RD, Wang D, Sayre LM, Smith MA, Chen SG, Bush AI. Copper mediates dityrosine cross-linking of Alzheimer's amyloid-beta. Biochemistry. 2004 Jan 20; 43(2):560-8. PMID: 14717612.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  88. Nagano S, Huang X, Moir RD, Payton SM, Tanzi RE, Bush AI. Peroxidase activity of cyclooxygenase-2 (COX-2) cross-links beta-amyloid (Abeta) and generates Abeta-COX-2 hetero-oligomers that are increased in Alzheimer's disease. J Biol Chem. 2004 Apr 09; 279(15):14673-8. PMID: 14724276.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  89. Bush AI, Huang X, Atwood CS, Tanzi RE. Methods for Identifying an Agent that Inhibits Oxygen-dependent Hydrogen Peroxide Formation Activity but Does Not Inhibit Superoxide-dependent Hydrogen Peroxide Formation. 2003.
  90. Goldstein LE, Muffat JA, Cherny RA, Moir RD, Ericsson MH, Huang X, Mavros C, Coccia JA, Faget KY, Fitch KA, Masters CL, Tanzi RE, Chylack LT, Bush AI. Cytosolic beta-amyloid deposition and supranuclear cataracts in lenses from people with Alzheimer's disease. Lancet. 2003 Apr 12; 361(9365):1258-65. PMID: 12699953.
    Citations: 80     Fields:    Translation:Humans
  91. Friedlich AL, Huang X, Nagano S, Rogers JT, Goldstein LE, Bush AI, Multhaup G, Beyreuther K, Stremmel W, Bayer T. Metal Ions and Neurodegenerative Disorders (Zatta P, editor). Importance of copper and zinc in Alzheimer’s disease and the biology of amyloid-ß protein and amyloid-ß protein precursor. 2003; 245-61.
  92. Evin G, Sernee MF, Barnham KJ, Holsinger RMD, Culvenor JG, Hoke DE, Li Q-X, Smith D, Maynard C, Tickler A, Huang X, Opazo C, Carrington D, Kocak G, Volitakis I, Mok S, Ciccotosto G, Williamson NA, Beyreuther K, Wade J, Curtain CC, Cherny RA, Bush AI, Masters CL, Cappai R. Alzheimer’s Disease and Related Disorders: Research Advances. Proceedings of the 8th International Conference on Alzheimer's Disease and Related Disorders (Iqbal K and Winblad B, editors). Modulation of Alzheimer’s Disease Aß Pathways for rational therapeutic Intervention: Secretase Inhibition and Metalloprotein Active Compounds. 2003; 513-23.
  93. Rogers JT, Randall JD, Cahill CM, Eder PS, Huang X, Gunshin H, Leiter L, McPhee J, Sarang SS, Utsuki T, Greig NH, Lahiri DK, Tanzi RE, Bush AI, Giordano T, Gullans SR. An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript. J Biol Chem. 2002 Nov 22; 277(47):45518-28. PMID: 12198135.
    Citations: 134     Fields:    Translation:HumansAnimalsCells
  94. Opazo C, Huang X, Cherny RA, Moir RD, Roher AE, White AR, Cappai R, Masters CL, Tanzi RE, Inestrosa NC, Bush AI. Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2). J Biol Chem. 2002 Oct 25; 277(43):40302-8. PMID: 12192006.
    Citations: 105     Fields:    Translation:HumansAnimalsCells
  95. Rogers JT, Randall JD, Eder PS, Huang X, Bush AI, Tanzi RE, Venti A, Payton SM, Giordano T, Nagano S, Cahill CM, Moir R, Lahiri DK, Greig N, Sarang SS, Gullans SR. Alzheimer's disease drug discovery targeted to the APP mRNA 5'untranslated region. J Mol Neurosci. 2002 Aug-Oct; 19(1-2):77-82. PMID: 12212798.
    Citations: 14     Fields:    Translation:HumansCells
  96. Rogers JT, Huang X, Bush AI. Neuroprotection (Lo EH, Marwah J., editors). Therapeutic targets for Alzheimer's disease. 2002; 561-89.
  97. Bush AI, Huang X, Atwood CS, Tanzi RE. Agents for Use in the Treatment of Alzheimer's Disease. 2001.
  98. Tsai G, Huang X, Bush AI. Methods for Screening Drugs to Predict Tardive Dyskinesia. 2001.
  99. Jobling MF, Huang X, Stewart LR, Barnham KJ, Curtain C, Volitakis I, Perugini M, White AR, Cherny RA, Masters CL, Barrow CJ, Collins SJ, Bush AI, Cappai R. Copper and zinc binding modulates the aggregation and neurotoxic properties of the prion peptide PrP106-126. Biochemistry. 2001 Jul 10; 40(27):8073-84. PMID: 11434776.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  100. Cherny RA, Atwood CS, Xilinas ME, Gray DN, Jones WD, McLean CA, Barnham KJ, Volitakis I, Fraser FW, Kim Y, Huang X, Goldstein LE, Moir RD, Lim JT, Beyreuther K, Zheng H, Tanzi RE, Masters CL, Bush AI. Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice. Neuron. 2001 Jun; 30(3):665-76. PMID: 11430801.
    Citations: 265     Fields:    Translation:Animals
  101. White AR, Huang X, Jobling MF, Barrow CJ, Beyreuther K, Masters CL, Bush AI, Cappai R. Homocysteine potentiates copper- and amyloid beta peptide-mediated toxicity in primary neuronal cultures: possible risk factors in the Alzheimer's-type neurodegenerative pathways. J Neurochem. 2001 Mar; 76(5):1509-20. PMID: 11238735.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  102. Huang X, Keskin SS, Gullu G, Olmez I. Wet deposition flux of trace elements to the Adirondack region. J. Radioanal. Nucl. Chem. 2001; 247:317-23.
  103. Atwood CS, Huang X, Moir RD, Smith MA, Tanzi RE, Roher AE, Bush AI, Perry G. Alzheimer’s Disease: Biology, Diagnosis and Therapeutics. Proceedings of the 7th International Conference on Alzheimer's Disease and Related Disorders (Iqbal K, Winblad B, Nishimura T, Takeda M, Wisniewski HM, editors). Neuroinflammatory responses in the Alzheimer’s disease brain promote the oxidative post-translational modification of amyloid deposits. 2001; 341-61.
  104. Atwood CS, Scarpa RC, Huang X, Moir RD, Jones WD, Fairlie DP, Tanzi RE, Bush AI. Characterization of copper interactions with alzheimer amyloid beta peptides: identification of an attomolar-affinity copper binding site on amyloid beta1-42. J Neurochem. 2000 Sep; 75(3):1219-33. PMID: 10936205.
    Citations: 102     Fields:    Translation:HumansAnimalsCells
  105. Cuajungco MP, Goldstein LE, Nunomura A, Smith MA, Lim JT, Atwood CS, Huang X, Farrag YW, Perry G, Bush AI. Evidence that the beta-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of abeta by zinc. J Biol Chem. 2000 Jun 30; 275(26):19439-42. PMID: 10801774.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  106. Goldstein LE, Leopold MC, Huang X, Atwood CS, Saunders AJ, Hartshorn M, Lim JT, Faget KY, Muffat JA, Scarpa RC, Chylack LT, Bowden EF, Tanzi RE, Bush AI. 3-Hydroxykynurenine and 3-hydroxyanthranilic acid generate hydrogen peroxide and promote alpha-crystallin cross-linking by metal ion reduction. Biochemistry. 2000 Jun 20; 39(24):7266-75. PMID: 10852726.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  107. Atwood CS, Huang X, Khatri A, Scarpa RC, Kim YS, Moir RD, Tanzi RE, Roher AE, Bush AI. Copper catalyzed oxidation of Alzheimer Abeta. Cell Mol Biol (Noisy-le-grand). 2000 Jun; 46(4):777-83. PMID: 10875439.
    Citations: 16     Fields:    Translation:HumansCells
  108. Bush AI, Atwood CS, Goldstein LE, Huang X, Rogers J. Could Abeta and AbetaPP be Antioxidants? J Alzheimers Dis. 2000 Jun; 2(2):83-84. PMID: 12214093.
    Citations: 1     Fields:    
  109. Huang X, Cuajungco MP, Atwood CS, Moir RD, Tanzi RE, Bush AI. Alzheimer's disease, beta-amyloid protein and zinc. J Nutr. 2000 05; 130(5S Suppl):1488S-92S. PMID: 10801964.
    Citations: 15     Fields:    Translation:Humans
  110. Cuajungco MP, Fagét KY, Huang X, Tanzi RE, Bush AI. Metal chelation as a potential therapy for Alzheimer's disease. Ann N Y Acad Sci. 2000; 920:292-304. PMID: 11193167.
    Citations: 35     Fields:    Translation:Humans
  111. Huang X, Cuajungco MP, Atwood CS, Hartshorn MA, Tyndall JD, Hanson GR, Stokes KC, Leopold M, Multhaup G, Goldstein LE, Scarpa RC, Saunders AJ, Lim J, Moir RD, Glabe C, Bowden EF, Masters CL, Fairlie DP, Tanzi RE, Bush AI. Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction. J Biol Chem. 1999 Dec 24; 274(52):37111-6. PMID: 10601271.
    Citations: 133     Fields:    Translation:AnimalsCells
  112. Cherny RA, Legg JT, McLean CA, Fairlie DP, Huang X, Atwood CS, Beyreuther K, Tanzi RE, Masters CL, Bush AI. Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion. J Biol Chem. 1999 Aug 13; 274(33):23223-8. PMID: 10438495.
    Citations: 76     Fields:    Translation:Humans
  113. Moir RD, Atwood CS, Huang X, Tanzi RE, Bush AI. Mounting evidence for the involvement of zinc and copper in Alzheimer's disease. Eur J Clin Invest. 1999 Jul; 29(7):569-70. PMID: 10411660.
    Citations: 3     Fields:    Translation:Humans
  114. Huang X, Atwood CS, Hartshorn MA, Multhaup G, Goldstein LE, Scarpa RC, Cuajungco MP, Gray DN, Lim J, Moir RD, Tanzi RE, Bush AI. The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction. Biochemistry. 1999 Jun 15; 38(24):7609-16. PMID: 10386999.
    Citations: 173     Fields:    Translation:HumansAnimalsCells
  115. Bus AI, Huang X, Fairlie DP. The possible origin of free radicals from amyloid beta peptides in Alzheimer's disease. Neurobiol Aging. 1999 May-Jun; 20(3):335-7; discussion 339-42. PMID: 10588582.
    Citations: 5     Fields:    Translation:HumansCells
  116. Moir RD, Atwood CS, Romano DM, Laurans MH, Huang X, Bush AI, Smith JD, Tanzi RE. Differential effects of apolipoprotein E isoforms on metal-induced aggregation of A beta using physiological concentrations. Biochemistry. 1999 Apr 06; 38(14):4595-603. PMID: 10194381.
    Citations: 15     Fields:    Translation:HumansCells
  117. Atwood CS, Huang X, Moir RD, Tanzi RE, Bush AI. Role of free radicals and metal ions in the pathogenesis of Alzheimer's disease. Met Ions Biol Syst. 1999; 36:309-64. PMID: 10093929.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  118. Huang X, Atwood CS, Goldstein LE, Hartshorn MA, Saunders AJ, Moir RD, Tanzi RE, Bush AI. Alzheimer’s Disease: Biology, Diagnosis and Therapeutics. Proceedings of the 6th International Conference on Alzheimer's Disease and Related Disorders (Iqbal K, Winblad B, Nishimura T, Takeda M, Wisniewski HM, editors). Metal-catalyzed redox activity of Aß: the major source of amyloid-associated oxidative stress in Alzheimer's disease. 1999; 383-90.
  119. Atwood CS, Moir RD, Huang X, Scarpa RC, Bacarra NM, Romano DM, Hartshorn MA, Tanzi RE, Bush AI. Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis. J Biol Chem. 1998 May 22; 273(21):12817-26. PMID: 9582309.
    Citations: 160     Fields:    Translation:HumansAnimalsCells
  120. Huang X, Atwood CS, Moir RD, Hartshorn MA, Vonsattel JP, Tanzi RE, Bush AI. Zinc-induced Alzheimer's Abeta1-40 aggregation is mediated by conformational factors. J Biol Chem. 1997 Oct 17; 272(42):26464-70. PMID: 9334223.
    Citations: 42     Fields:    Translation:HumansCells
  121. Atwood CS, Moir RD, Huang X, Tanzi RE, Bush AI. Molecular mechanisms of dementia (Tanzi RE, Wasco WM, editors). Cerebral zinc metabolism in Alzheimer’s disease. 1997; 225-37.
  122. Atwood CS, Huang X, Moir RD, Tanzi RE, Bush AI. Alzheimer’s Disease: Biology, Diagnosis and Therapeutics. Proceedings of the 5th International Conference on Alzheimer's Disease and Related Disorders (Iqbal K, Winblad B, Nishimura T, Takeda M, Wisniewski HM, editors). Neurochemical environments that precipitate Aß. 1997; 329-37.
  123. Huang X, Gullu G, Che J, Keskin S, Pink F, Olmez I. A Speciality Conference on Visual Air Quality, Aerosols, and Global Radiation Balance sponsored by the Air & Waste Management Association and the American Geophysical Union. Wet deposition flux of trace elements to the Adirondack Region. 1997.
  124. Huang X, Keskin SS, Pink F, Olmez I. Possible roles of transition metals in cloudwater relative to the solar short-wave radiation absorption. Tr. J. of Chemistry. 1997; 21:369-75.
  125. Xudong Huang. Chemometric Studies of Cloudwater and Wet Deposition [Ph.D. dissertation]. 1995.
  126. Aras NK, Huang X, Olmez I, Gordon GE. Composition and sources of atmospheric particulate matter at an industrialized urban air shed. Tr. J. of Engineering and Environmental Sciences. 1995; 19:1-13.
  127. Olmez I, Huang X, Ames MR. The role of instrumental Neutron Activation in environmental mercury analysis. 1995.
  128. Huang X, Olmez I, Aras NK, Gordon GE. Emissions of trace elements from motor vehicles: potential marker elements and source composition profile. Atmospheric Environment. 1994; 28:1385-91.
  129. Lamborg CH, Hoyer ME, Keeler GJ, Olmez I, Huang X. Mercury as a Global Pollutant: Toward Integration and Synthesis (Huckabee, J. and Watras, C., Editors). Particulate phase mercury in the atmosphere collection/analysis method development and applications. 1993.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.