Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Nicholas Eveleth Todd, Ph.D.

Title
Institution
Department
Address

Mentoring
Available: 02/18/22, Expires: 03/01/24

Our lab uses the technology of focused ultrasound to transiently disrupt the blood-brain barrier for improved delivery of drugs to the brain. We have several preclinical research projects in this area combining different therapeutics and disease targets. We also help lead a Phase 1 clinical trial using the approach to improve delivery of chemotherapy treatment to glioblastoma patients here at Brigham and Women's hospital. The projects available to a student would involve assessment of treatment safety and efficacy markers in mice. For example, one project is delivering an AAV-packaged gene therapy to a mouse model of Huntingtons disease to lower expression of the toxic HTT protein. The student would be responsible for sectioning, staining, and imaging mouse brains to assess markers of delivery efficacy (e.g., GFP) and safety (e.g. GFAP, Iba1). Another project is evaluating the safety of focused ultrasound BBB disruption over a range of ultrasound parameters. The student would be responsible for sectioning, staining, and imaging mouse brains to evaluate a wide range of inflammatory markers and assist with PCR assessment of RNA levels.


Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21EB030173 (TODD, NICHOLAS E.) Sep 2, 2020 - Jun 30, 2023
    NIH
    Understanding the relationships between FUS-BBB opening, neuroinflammation and the neurovascular response
    Role: Principal Investigator
  2. K01EB023983 (TODD, NICHOLAS E.) Jul 1, 2017 - Mar 31, 2021
    NIH
    Non-invasive neuromodulation via targeted delivery of neurotransmitter chemicals
    Role: Principal Investigator
  3. F32EB012917 (TODD, NICHOLAS E.) Sep 30, 2011 - Sep 29, 2013
    NIH
    MR Temperature Measurements in Fat During MR-Guided HIFU Treatments
    Role: Principal Investigator
  4. F31EB007892 (TODD, NICHOLAS E.) Sep 20, 2007 - Sep 19, 2009
    NIH
    Improved MRI techniques for measurement of absolute temperature distributions
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. van Gool R, Tucker-Bartley A, Yang E, Todd N, Guenther F, Goodlett B, Al-Hertani W, Bodamer OA, Upadhyay J. Targeting neurological abnormalities in lysosomal storage diseases. Trends Pharmacol Sci. 2021 Nov 27. PMID: 34844772.
    Citations:    Fields:    
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact contactcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Todd's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Co-Authors (6)
Explore
_
Same Department 
Explore
_
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.