Harvard Catalyst Profiles

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Nicholas Eveleth Todd, Ph.D.


Available: 02/18/22, Expires: 03/01/24

Our lab uses the technology of focused ultrasound to transiently disrupt the blood-brain barrier for improved delivery of drugs to the brain. We have several preclinical research projects in this area combining different therapeutics and disease targets. We also help lead a Phase 1 clinical trial using the approach to improve delivery of chemotherapy treatment to glioblastoma patients here at Brigham and Women's hospital. The projects available to a student would involve assessment of treatment safety and efficacy markers in mice. For example, one project is delivering an AAV-packaged gene therapy to a mouse model of Huntingtons disease to lower expression of the toxic HTT protein. The student would be responsible for sectioning, staining, and imaging mouse brains to assess markers of delivery efficacy (e.g., GFP) and safety (e.g. GFAP, Iba1). Another project is evaluating the safety of focused ultrasound BBB disruption over a range of ultrasound parameters. The student would be responsible for sectioning, staining, and imaging mouse brains to evaluate a wide range of inflammatory markers and assist with PCR assessment of RNA levels.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21EB030173 (TODD, NICHOLAS E.) Sep 2, 2020 - Jun 30, 2023
    Understanding the relationships between FUS-BBB opening, neuroinflammation and the neurovascular response
    Role: Principal Investigator
  2. K01EB023983 (TODD, NICHOLAS E.) Jul 1, 2017 - Mar 31, 2021
    Non-invasive neuromodulation via targeted delivery of neurotransmitter chemicals
    Role: Principal Investigator
  3. F32EB012917 (TODD, NICHOLAS E.) Sep 30, 2011 - Sep 29, 2013
    MR Temperature Measurements in Fat During MR-Guided HIFU Treatments
    Role: Principal Investigator
  4. F31EB007892 (TODD, NICHOLAS E.) Sep 20, 2007 - Sep 19, 2009
    Improved MRI techniques for measurement of absolute temperature distributions
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. van Gool R, Tucker-Bartley A, Yang E, Todd N, Guenther F, Goodlett B, Al-Hertani W, Bodamer OA, Upadhyay J. Targeting neurological abnormalities in lysosomal storage diseases. Trends Pharmacol Sci. 2021 Nov 27. PMID: 34844772.
    Citations:    Fields:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.